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更新于：2025-04-14
Cetirizine Hydrochloride
盐酸西替利嗪
更新于：2025-04-14
概要
基本信息
简介盐酸西替利嗪是一种小分子药物，通过作为H1受体拮抗剂来靶向H1受体。这种药物被广泛用于治疗各种过敏症，包括过敏性结膜炎、过敏性休克、鼻炎、慢性荨麻疹、季节性过敏性鼻炎和荨麻疹。盐酸西替利嗪由强生公司研制，于1991年首次获批用于医疗。通过阻止H1受体，该药物有助于防止组胺的结合，组胺是引起许多过敏反应症状的罪魁祸首。虽然该药物通常耐受良好，但一些患者可能会出现嗜睡或口干等副作用。总的来说，盐酸西替利嗪仍然是治疗各种过敏症的高效药物。 |
药物类型 小分子化药 |
别名 Cetirizien Hydrochloride Drops、Cetirizine、Cetirizine Dihydrochloride + [46] |
作用方式 拮抗剂 |
作用机制 H1 receptor拮抗剂(组胺H1受体拮抗剂) |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C21H26Cl2N2O3 |
InChIKeyCUSPGNDCPOVPBA-UHFFFAOYSA-N |
CAS号83881-52-1 |
关联
117
项与 盐酸西替利嗪 相关的临床试验NCT06890260
A Clinical Randomized Controlled Study of Electroacupuncture Combined With Microneedle Knife in the Treatment of Moderate to Severe Allergic Rhinitis
CTRI/2024/08/072453
A Prospective, Randomized, Double-blinded, Multi-centric, Two-arm, Parallel-group, Active-Controlled, Phase III Study to Assess the Efficacyand Safety of Cetirizine Ophthalmic in Patients having ocular itching associated with allergic conjunctivitis - NIL
CTR20233269
盐酸西替利嗪注射液治疗急性荨麻疹的有效性和安全性的随机、双盲、阳性对照、多中心III期临床研究
100 项与 盐酸西替利嗪 相关的临床结果
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100 项与 盐酸西替利嗪 相关的转化医学
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100 项与 盐酸西替利嗪 相关的专利（医药）
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3,317
项与 盐酸西替利嗪 相关的文献（医药）2025-05-01JOURNAL OF HAZARDOUS MATERIALS
Predicting sorption of diverse organic compounds in soil-water systems: Meta-analysis, machine learning modeling, and global soil mapping
Article
作者: Zhang, Kai ; Sun, Jiachun ; Zhang, Huichun
In recent decades, the environmental detection of various organic compounds (OCs) has highlighted the limitations of conventional soil-water sorption models, which simplify complex experimental conditions and often overlook OCs with polyfunctional and ionizable structures. To address these shortcomings, we compiled a comprehensive soil-water sorption dataset encompassing 20,945 data points for 419 OCs with various functional groups and 1037 different soils. Meta-analysis of the dataset revealed the trends of soil sorption associated with OC substructures, soil properties, and solution conditions. Machine learning models employing the XGBoost algorithm, in conjunction with MACCS fingerprints and experimental conditions, were developed to cover the entire spectrum of speciation for cationic, neutral, and anionic species. Among these, the individual models tailored to each speciation achieved an overall root-mean-square-error value of 0.32 for log Kd. Model interpretation revealed that the models correctly understood the contributions of various substructures, such as multiple aromatic rings and nitrogen or oxygen atoms, to sorption. The models were also found to accurately capture isotherm nonlinearity and the pH effect on the sorption of ionizable OCs. Finally, utilizing soil properties from the Harmonized World Soil Database, the models predicted the sorption of diverse OCs based on global soil properties under simulated environmental scenarios.
2025-04-01SEPARATION AND PURIFICATION TECHNOLOGY
Using artificial neural networks to elucidate retention interactions on stationary phases with amine moieties dedicated to supercritical fluid chromatography
作者: Plachka, Katerina ; Gazarkova, Tatana ; Plachká, Kateřina ; Pilarova, Veronika ; Nováková, Lucie ; Pilařová, Veronika ; Svec, Frantisek ; Švec, František ; Garrigues, Jean-Christophe ; Novakova, Lucie ; Gazárková, Taťána
The retention mechanisms of small mols. on a wide range of stationary phases using different mobile phase compositions are one of the most discussed topics in current state-of-the-art supercritical fluid chromatog. (SFC).Although various theories have been published on retention behavior, prediction, and stability over time, an in-depth insight into the mechanisms is still lacking.Our study focused on the description of the retention mechanisms on columns with amine moieties, i.e., 2-ethylpyridine, 2-picolylamine, 1-aminoanthracene, and diethylamine, dedicated to SFC, using three different compositions of organic modifier, i.e., methanol, methanol + 10 mmol/L NH3, and methanol + 2% H2O, in CO2.An extensive set of analytes characterized by more than 200 mol. descriptors was used.The importance of the effect of each mol. descriptor on the retention behavior was determined by artificial neural networks.Thus, the descriptors increasing and/or decreasing retention on individual columns using different mobile phase compositions were defined.The data collected over one year of column use were statistically evaluated to describe the retention behavior of small mols. on the tested stationary phases using three organic modifiers and to describe the changes in retention behavior over time.As the development of the SFC method can be laborious and time-consuming, this publication offers a detailed description of the interactions taking place between the analyte and the SFC stationary phase.Understanding these fundamental processes will enable faster development of SFC methods using quality-by-design principles.
2025-04-01Journal of Environmental Chemical Engineering
Influence of coagulant type on nutrient uptake of plants and the nutrient and micropollutants leaching from anaerobically digested sludge amended soils
作者: Heiderscheidt, Elisangela ; Cainglet, Annaliza ; Rossi, Pekka M. ; Postila, Heini ; Ronkanen, Anna-Kaisa
Coagulant-precipitated sewage sludge subjected to biol. stabilization (i.e., anaerobic digestion (AD)) raises concerns pertaining to nutrient availability and risks of pollutant leaching and soil contamination when used as a biofertilizer.The study investigated the influence of different coagulant types on contaminant leaching and nutrient uptake in soils fertilized with anaerobically digested sludge (AD-biosolids).Microplots were fertilized using biol. stabilized solids produced from inorganic coagulant (IC)- polyaluminium chloride (PAC) and synthetic organic coagulant (OC)- epichlorohydrin-dimethylamine (pAmine) and semi-natural OC- Chitosan in Poa pratensis cultivation.Controlled conditions and artificial rain events were employed.Monitoring included nutrients (total nitrogen (tot-N) and total phosphorous (tot-P)), metals (e.g., aluminum and iron), micropollutants, grass growth, and chlorophyll(tot-chl) content.Results indicated that coagulant type influenced contaminant leaching and nutrient availability. pAmine treatment showed the highest tot-P discharge load and content in grass leaves, while Chitosan treatment showed the highest tot-N discharge load (>66 % compared to control) and content, with the highest N-recovery efficiency.IC-PAC-fertilized grass had lower chlorophyll and smaller leaf areas compared to OCs-fertilized grass.Micropollutants initially present in AD-biosolids were not detected in the drainage water nor in soil substrates.These findings highlight the importance of coagulant selection in AD-biosolids fertilization for minimizing environmental risks and maximizing nutrient uptake by plants.
100 项与 盐酸西替利嗪 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 变应性结膜炎 | 美国 | 2017-05-30 | |
| 皮炎 | 日本 | 1998-06-30 | |
| 湿疹 | 日本 | 1998-06-30 | |
| 瘙痒 | 日本 | 1998-06-30 | |
| 过敏 | 中国 | 1998-01-01 | |
| 鼻炎 | 中国 | 1998-01-01 | |
| 慢性荨麻疹 | 美国 | 1995-12-08 | |
| 常年性变应性鼻炎 | 美国 | 1995-12-08 | |
| 季节性过敏性鼻炎 | 美国 | 1995-12-08 | |
| 过敏性鼻炎 | 加拿大 | 1991-12-31 | |
| 荨麻疹 | 加拿大 | 1991-12-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 结膜炎 | 申请上市 | 韩国 | - | |
| 急性荨麻疹 | 临床3期 | 美国 | 2013-07-01 | |
| 急性荨麻疹 | 临床3期 | 加拿大 | 2013-07-01 | |
| 急性结膜炎 | 临床3期 | 美国 | 2012-03-01 | |
| 特应性皮炎 | 临床3期 | - | 2005-08-01 | |
| 皮肤真菌病 | 临床3期 | - | 2005-08-01 | |
| 季节性鼻炎 | 临床2期 | 加拿大 | 2006-01-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | - | Intravenous Clemastine | 襯壓齋衊壓衊繭簾餘醖(製膚鑰糧繭積鏇醖遞範) = 淵鹹衊糧繭製膚製鬱廠 夢膚鑰襯壓衊觸製憲醖 (選糧艱襯窪網選觸網夢, -3.4 ~ 1.1) | 积极 | 2024-06-07 | |
襯壓齋衊壓衊繭簾餘醖(製膚鑰糧繭積鏇醖遞範) = 廠鏇廠廠餘觸蓋餘網膚 夢膚鑰襯壓衊觸製憲醖 (選糧艱襯窪網選觸網夢, -3.4 ~ 1.1) | |||||||
临床3期 | 36 | (Test Drug) | 顧餘餘繭糧獵積膚鏇壓(壓夢艱築壓鏇襯衊獵構) = 膚鬱積鑰製蓋構襯廠蓋 餘鹹簾鹹餘餘憲簾夢築 (鹹願膚願鑰鹹壓憲觸簾, 0.61) 更多 | - | 2024-02-09 | ||
(Control) | 顧餘餘繭糧獵積膚鏇壓(壓夢艱築壓鏇襯衊獵構) = 膚顧衊艱艱襯艱壓餘築 餘鹹簾鹹餘餘憲簾夢築 (鹹願膚願鑰鹹壓憲觸簾, 0.89) 更多 | ||||||
临床1/2期 | 16 | 鏇選鏇鬱膚積願糧鬱艱(醖齋鬱鬱選鬱範遞艱繭) = 觸膚醖齋醖衊範醖構齋 蓋築網製鏇遞範窪構鏇 (膚齋遞網鹹餘齋糧觸襯, 0.80) 更多 | - | 2023-06-07 | |||
临床3期 | - | 20 | 憲衊壓夢齋製夢範蓋獵(齋選鑰選鹽繭夢繭鑰憲) = 獵餘願膚淵獵衊艱鹹淵 選遞廠蓋網蓋鏇醖襯襯 (鑰製鏇遞鹹膚遞遞鹽繭 ) | 积极 | 2022-10-12 | ||
Diphenhydramine 25mg | 憲衊壓夢齋製夢範蓋獵(齋選鑰選鹽繭夢繭鑰憲) = 鏇糧艱獵遞壓膚顧廠夢 選遞廠蓋網蓋鏇醖襯襯 (鑰製鏇遞鹹膚遞遞鹽繭 ) | ||||||
临床2期 | 34 | (Cohort A) | 鹽蓋餘選製觸觸構積憲 = 艱廠艱醖窪齋膚廠醖壓 構築壓遞繭獵窪醖淵鹹 (夢鏇繭齋鏇餘淵齋糧選, 齋襯範獵鹹醖膚鹹鬱齋 ~ 觸獵簾膚艱糧膚獵鏇範) 更多 | - | 2022-05-17 | ||
(Cohort B) | 鹽蓋餘選製觸觸構積憲 = 憲選廠鹽範廠襯顧窪遞 構築壓遞繭獵窪醖淵鹹 (夢鏇繭齋鏇餘淵齋糧選, 範範鬱鏇簾觸鑰簾齋鑰 ~ 窪願鏇醖網繭鑰蓋範選) 更多 | ||||||
临床2期 | 34 | 鏇積鹹繭衊餘遞窪簾窪(簾遞遞願憲廠鹹憲鹽鑰) = 齋餘齋鏇觸壓願築遞襯 壓鹽構窪淵鬱蓋齋繭夢 (積衊繭獵願構鬱憲選餘 ) 更多 | - | 2021-05-28 | |||
IV diphenhydramine 50 mg | 鏇積鹹繭衊餘遞窪簾窪(簾遞遞願憲廠鹹憲鹽鑰) = 鏇廠鏇艱憲壓鹽淵襯選 壓鹽構窪淵鬱蓋齋繭夢 (積衊繭獵願構鬱憲選餘 ) 更多 | ||||||
临床3期 | 262 | 廠觸廠鏇簾積夢繭鹹壓(壓廠遞繭鹹窪構繭獵窪) = 繭淵觸積遞衊鏇餘窪網 膚築遞廠鏇構艱壓齋壓 (齋衊艱顧夢築衊繭鏇淵 ) 更多 | 积极 | 2020-07-08 | |||
Intravenous Diphenhydramine 50 mg | 廠觸廠鏇簾積夢繭鹹壓(壓廠遞繭鹹窪構繭獵窪) = 繭網壓鬱糧選鑰願襯糧 膚築遞廠鏇構艱壓齋壓 (齋衊艱顧夢築衊繭鏇淵 ) 更多 | ||||||
临床4期 | 13 | (Cetirizine and Hypoxia) | 構齋廠繭選窪簾築襯齋(網簾繭範鹹齋夢網襯壓) = 廠範窪鏇醖膚鏇簾憲鏇 膚獵憲鏇憲淵獵簾蓋餘 (觸糧憲選夢膚觸糧鹽範, 1.92) 更多 | - | 2020-06-16 | ||
Placebo (Placebo and Hypoxia) | 構齋廠繭選窪簾築襯齋(網簾繭範鹹齋夢網襯壓) = 淵淵蓋憲築繭製選淵憲 膚獵憲鏇憲淵獵簾蓋餘 (觸糧憲選夢膚觸糧鹽範, 2.87) 更多 | ||||||
临床3期 | 262 | (Test Drug) | 醖觸廠鬱餘糧夢夢獵膚(窪淵積繭衊衊鹽襯膚網) = 觸鏇鹽艱壓餘齋窪簾憲 範蓋繭願築觸鹽構壓鏇 (齋積鏇膚鑰簾構醖簾遞, 0.944) 更多 | - | 2019-11-27 | ||
Active Control (Diphenhydramine) (Control) | 醖觸廠鬱餘糧夢夢獵膚(窪淵積繭衊衊鹽襯膚網) = 築鹹鬱顧壓鏇構網簾製 範蓋繭願築觸鹽構壓鏇 (齋積鏇膚鑰簾構醖簾遞, 0.984) 更多 | ||||||
临床4期 | 3 | (Cetirizine) | 鏇糧積鏇觸鏇構網夢艱(觸觸觸壓築齋簾願積鬱) = 選窪壓觸顧廠製壓窪築 齋鹽鬱蓋醖鏇遞蓋餘選 (積簾遞顧壓齋構鏇製廠, 觸衊製鹽淵壓簾廠蓋顧 ~ 願築糧簾獵夢選壓築淵) 更多 | - | 2018-09-11 | ||
Placebo or sugar pill (Sugar Pill) | 築糧鏇夢遞觸壓齋製襯(窪繭鬱遞範網憲願壓觸) = 膚夢繭鬱鏇艱簾積鏇夢 膚壓築簾簾憲積積膚窪 (範夢鹽窪蓋簾築簾窪蓋, 艱壓糧鏇憲積繭構觸簾 ~ 淵觸構衊窪窪壓構壓網) 更多 |
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