牛至提取物(Oregano extract) - _专利_临床

概要

基本信息

药物类型

中药

别名

Oregano extract cream

靶点-

作用机制-

治疗领域

免疫系统疾病遗传病与畸形皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

特应性皮炎

原研机构

Rutgers State University of New Jersey

在研机构

Washington State University

非在研机构

Rutgers State University of New Jersey

最高研发阶段早期临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与牛至提取物相关的临床试验

NCT06693960

/ Recruiting早期临床1期IIT

Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach

The purpose of this clinical trial is to determine how the supplement oregano affects how the body metabolizes pharmaceutical drugs.

开始日期2024-09-26

申办/合作机构

Washington State University

[+2]

NCT02289989

/ TerminatedN/AIIT

Investigator-Initiated, Randomized, Investigator-Blind, Half-Side Comparison of Topical Oregano Extract Ointment vs .Hydrocortisone 1% for the Treatment of Atopic Dermatitis in Pediatric Patients

This study is designed to evaluate and compare the efficacy of 3% oregano extract ointment prepared in aqueous solution versus 1% hydrocortisone ointment, a standard treatment, in decreasing the inflammation associated with mild to moderate atopic dermatitis. We plan to recruit 40 patients on the ages comprised between 2 and 17 years old and the study duration for each of the patient is 1 month.

开始日期2014-11-01

申办/合作机构

Rutgers State University of New Jersey

100 项与牛至提取物相关的临床结果

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100 项与牛至提取物相关的转化医学

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100 项与牛至提取物相关的专利（医药）

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239

项与牛至提取物相关的文献（医药）

2025-02-01·Poultry Science

Molecular responses to clove and oregano essential oils are associated with reduced inflammation and improved gut barrier function in broiler chickens

Article

作者: Nam, Hyoyoun ; Park, Inkyung ; Wall, Emma H ; Lillehoj, Hyun S ; Ravichandran, Sripathy

In vitro tests were conducted to characterize the host-mediated responses of chickens to Clove Essential Oil (CEO) and Oregano Essential Oil (OEO). Chicken macrophage cells (CMCs), chicken intestinal epithelial cells (IECs), quail muscle cells (QMCs), and chicken embryonic muscle cells (EMCs) were utilized in these assays. EMCs were collected from the 13-day-old embryo during egg incubation and all cell lines were seeded at 2 × 10⁵/mL in a 24-well plate. In CMCs, an inflammatory response was induced by stimulating with 1.0 µg/mL of Lipopolysaccharide (LPS). To induce muscle cell differentiation, 0.5 % FBS was used in QMCs and 2.0 % FBS in EMCs. Three different concentrations (1.0, 10.0, and 100 µg/mL) of CEO and OEO were administered. qRT-PCR was used to measure gene expression levels of IL-1β and IL-8 from CMCs, occludin, ZO-1, and MUC2 from IECs, and Pax7 and MyoG from QMCs and EMCs. Cytotoxic effects of CEO and OEO were determined using an MTT assay; CEO and OEO did not show cytotoxicity at concentrations below 0.1 mg/mL in CMCs, IECs, QMCs, and EMCs. CEO reduced (P < 0.05) the LPS-induced increase of IL-1β and IL-8 in CMCs and increased (P < 0.05) ZO-1 and MUC2 in IECs. OEO suppressed (P < 0.05) the release of IL-8, increased ZO-1, and Pax7. Both CEO and OEO demonstrated microbicidal activity against sporozoite of E. tenella and C. perfringens bacteria, but only at doses 10-100 × higher than those that would be used in feed. These findings support our previous findings on other phytochemicals; both CEO and OEO are promising candidates for improved resilience in chickens not due to their direct antimicrobial effects, but due to gut physiological responses that take place at the level of the host.

2025-02-01·Annales de Cardiologie et d'Angéiologie

Origanum vulgare et risque hémorragique, à propos d'un cas

Article

作者: Belhachem, Abdelaali ; Hamidene, Imene ; Fendri, Allaoua Hicham ; Beghriche, Imene

INTRODUCTIONThe use of medicinal plants in Algeria is an ancestral practice that remains relevant today. The population relies on plants to treat various diseases and everyday ailments, which can be dangerous, especially when taking medication [1,2]. The interaction between plants and medication can lead to a modification of the plasma concentrations of the latter, which can impact its therapeutic effectiveness and be responsible for toxicity or therapeutic failure [1,2]. The interaction can also be pharmacodynamic, resulting in the potentiation of the effect or its antagonism. The risk is even higher when the medication has a narrow therapeutic range or presents high inter- or intra-individual variability, such as with vitamin K antagonist anticoagulants.CLINICAL CASEWe report the case of patient B.Z., aged 77, who is suffering from complete atrial fibrillation (ACFA). The patient has been under antivitamin K (AVK) treatment with acenocoumarol for 8 years and has been followed at the central laboratory of Didouche Mourad Hospital since August 2019. The patient has been stable with an INR within the therapeutic target range of 2-3 for 4 years. She is compliant and adheres to the dietary regimen. The dosage of acenocoumarol is alternated between 1/2 tablet and 1/4 tablet. On September 6, 2023, during a routine check-up, the patient's INR was 6.42, and the PT was 17.9%. The recommendation was to stop AVK and perform a control the following day. The interview revealed that the patient had started taking an infusion of oregano (Origanum vulgare), and occasionally verbena, at a rate of one 200 ml cup per day for a week. On September 7, 2023, the INR decreased to 3.80 and the PT to 26.9%, so the recommendation was to resume AVK at a dosage of 1/4 tablet to 1/2 tablet, with discontinuation of the herbal tea intake and an INR check after 72 hours. On the fourth day after resuming the anticoagulant, the INR was 2.5. Despite being informed of the risk of interaction, the patient resumed taking the freshly picked oregano herbal tea from her garden. Given the patient's determination to continue her infusion, the recommendation was made to limit her intake, to prepare much more diluted infusions, and to reduce the dose of acenocoumarol to 1/4 tablet; this allowed the stabilization of the patient's INR. The last check-up was performed on April 7, 2024, with an INR value of 2.3.RESULTSOregano, a plant from the Lamiaceae family, is used in herbal tea to treat a wide range of diseases, including joint pain, respiratory conditions, and digestive disorders. Similarly, verbena is also used to combat sleep disorders [2-4]. Origanum and verbena are both plants rich in polyphenols, as well as tannins and flavonoids. These substances are inhibitors of CYP 450, particularly CYP 2C9 and CYP 3A4, which are responsible for the metabolism of many drugs, including painkillers, antihypertensives, central nervous system drugs, and anticoagulants such as acenocoumarol. Origanum also exhibits anticoagulant activity due to its high content of carvacrol and thymol [4-6]. These two modes of interaction lead to an increase in the pharmacodynamic effect of acenocoumarol and, therefore, an increased risk of bleeding. This was the case for our patient, who saw her INR increase to more than twice the normal level, coinciding with the intake of oregano and verbena infusions, which normalized after their discontinuation.CONCLUSIONOregano is an endemic plant widely used in Algeria, whose anti-inflammatory properties are well established. However, its side effects, toxicity, and risk of interaction when combined with medications are less known. The interaction between oregano and AVK (acenocoumarol) exists and deserves to be recognized and monitored, especially in a population with a traditional culture where the use of plants is common. This practice should be accompanied by national phytovigilance.

2024-11-01·International Journal of Pharmaceutics

Oregano essential oil-infused mucin microneedle patch for the treatment of hypertrophic scar

Article

作者: Asad, Muhammad ; Ma, Xuejing ; Wan, Xiangling ; Zhang, Yuzhen ; Gu, Huan ; Shang, Hongtao ; Wang, Lei ; Zhang, Nan ; Younas, Ayesha

Hypertrophic scar (HS) manifests as abnormal dermal myofibroblast proliferation and excessive collagen deposition, leading to raised scars and significant physical, psychological, and financial burdens for patients. HS is difficult to cure in the clinic and current therapies lead to recurrence, pain, and side effects. In this study, a natural amphiphilic polymer mucin is used to prepare a dissolving microneedle (muMN) that is loaded with oregano essential oil (OEO) for HS therapy. muMN exhibits sufficient skin/scar tissue penetration, quick skin recovery time after removal, good loading of natural essential oil, fast dissolution and detachment from the base layer, and good biocompatibility to applied skin. In the rabbit HS model, OEO@muMN shows a significant reduction in scar thickness, epidermal thickness index, and scar elevation index. OEO@muMN also attenuates the mean collagen area fraction and decreases the number of capillaries in scar tissues. Biochemical Assay reveals that OEO@muMN significantly inhibits the expression of transforming growth factor-β1 (TGF-β1) and hydroxyproline (HYP). In summary, this study demonstrates the feasibility and good efficacy of using the anti-proliferative and anti-oxidative OEO for HS treatment. OEO@muMN is an efficient formulation that holds the potential for clinical anti-HS application. muMN is an efficient platform to load and apply essential oils transdermally.

100 项与牛至提取物相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
特应性皮炎	临床前	美国	Rutgers State University of New Jersey	2014-11-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


WCD2023	临床3期	中度至重度痤疮	-	Encapsulated BPO 5% cream	構艱齋蓋鬱窪範鏇淵膚(獵壓廠艱鬱構築鏇繭網) = 簾鹽鏇築鏇鏇淵鬱醖鹽齋醖範蓋襯夢鑰鹹鏇艱 (蓋觸襯壓蓋艱積廠餘製 )	-	2023-07-03
				Vehicle cream	構艱齋蓋鬱窪範鏇淵膚(獵壓廠艱鬱構築鏇繭網) = 製鏇鹽衊夢鏇襯蓋醖夢齋醖範蓋襯夢鑰鹹鏇艱 (蓋觸襯壓蓋艱積廠餘製 )
NCT02289989 (CTgov)	N/A	特应性皮炎	1	Hydrocortisone (Standard: Hydrocortisone 1% Ointment)	網鬱製築鹽餘製鹹簾廠(製鹽鬱遞構夢範餘艱築) = 製艱獵窪觸夢簾積壓壓獵願衊鹽選艱範壓艱壓 (選醖製艱壓觸膚觸廠觸, 鹹餘範選壓鹽鬱鹽廠憲 ~ 鬱齋壓壓製艱觸壓壓餘) 更多	-	2017-05-10
				Oregano extract cream (Experimental: Oregano Extract Cream)	窪簾蓋醖繭壓遞遞築願(淵糧憲襯繭糧醖憲築廠) = 網鹹膚鹹繭艱繭鏇膚鬱醖顧廠憲廠鬱鑰鹽膚築 (餘襯齋窪壓淵糧獵廠顧, 鬱遞襯鬱顧觸範繭醖鬱 ~ 網範襯蓋鏇廠淵鏇範憲) 更多