Investigator-Initiated, Randomized, Investigator-Blind, Half-Side Comparison of Topical Oregano Extract Ointment vs .Hydrocortisone 1% for the Treatment of Atopic Dermatitis in Pediatric Patients

This study is designed to evaluate and compare the efficacy of 3% oregano extract ointment prepared in aqueous solution versus 1% hydrocortisone ointment, a standard treatment, in decreasing the inflammation associated with mild to moderate atopic dermatitis. We plan to recruit 40 patients on the ages comprised between 2 and 17 years old and the study duration for each of the patient is 1 month.

开始日期2014-11-01

申办/合作机构

Rutgers State University of New Jersey

100 项与牛至提取物相关的临床结果

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100 项与牛至提取物相关的转化医学

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100 项与牛至提取物相关的专利（医药）

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228

项与牛至提取物相关的文献（医药）

2024-11-01·Veterinary Medicine and Science

Effects of cinnamon, rosemary and oregano on growth performance, blood biochemistry, liver enzyme activities, excreta microbiota and ileal morphology of Campylobacter jejuni‐challenged broiler chickens

Article

作者: Alimohammadi, Zahra ; Taherpour, Kamran ; Rahmatnejad, Enayat ; Khatibjoo, Ali ; Shirzadi, Hassan

AbstractBackgroundPhytogenic additives would be helpful to mitigate the detrimental impact of Campylobacter jejuni on broiler chickens.ObjectiveThe experiment aimed to assess the effects of cinnamon, rosemary and oregano powder on physiological responses of broiler chickens challenged with C. jejuni from 0 to 42 days of age.MethodsA total of 192 one‐day‐old male broiler chickens were divided into 6 treatment groups. The treatments included: negative control (NC; basal diet without additives and no C. jejuni challenge), positive control (PC; basal diet with C. jejuni challenge), PC with cinnamon, rosemary or oregano powder (3 g/kg each), and PC with Erythromycin (55 mg/kg). Except for the NC group, all chicks were orally challenged with 2 × 108 CFU/mL C. jejuni daily from days 21–25. Feed intake, body weight gain (BWG), feed conversion ratio (FCR), energy efficiency ratio (EER) and protein efficiency ratio (PER) were assessed during the rearing period (0–42 days). On day 42 of age, fresh excreta samples were collected from each pen to determine apparent dry matter digestibility and excreta microbiota. In addition, at the end of the experiment, blood samples were collected to evaluate blood profile and liver enzyme activities.ResultsC. jejuni challenge (PC treatment) decreased BWG, EER and PER, while increasing FCR of broiler chickens (p < 0.05), whereas rosemary, oregano and Erythromycin improved these performance parameters akin to NC. PC diet showed negative effect in ileal morphology, alleviated by additives except cinnamon (p < 0.05). Dietary additives successfully reduced Campylobacter levels and increased Lactobacilli counts in the PC. Rosemary and oregano lowered plasma total cholesterol (p < 0.05). Alanine aminotransferase elevation by C. jejuni challenge in the PC group was prevented by rosemary, oregano and Erythromycin (p < 0.05).ConclusionsOregano and rosemary alleviate the impact of C. jejuni challenge.

2024-11-01·International Journal of Pharmaceutics

Oregano essential oil-infused mucin microneedle patch for the treatment of hypertrophic scar

Article

作者: Asad, Muhammad ; Ma, Xuejing ; Wan, Xiangling ; Zhang, Yuzhen ; Gu, Huan ; Shang, Hongtao ; Wang, Lei ; Zhang, Nan ; Younas, Ayesha

Hypertrophic scar (HS) manifests as abnormal dermal myofibroblast proliferation and excessive collagen deposition, leading to raised scars and significant physical, psychological, and financial burdens for patients. HS is difficult to cure in the clinic and current therapies lead to recurrence, pain, and side effects. In this study, a natural amphiphilic polymer mucin is used to prepare a dissolving microneedle (muMN) that is loaded with oregano essential oil (OEO) for HS therapy. muMN exhibits sufficient skin/scar tissue penetration, quick skin recovery time after removal, good loading of natural essential oil, fast dissolution and detachment from the base layer, and good biocompatibility to applied skin. In the rabbit HS model, OEO@muMN shows a significant reduction in scar thickness, epidermal thickness index, and scar elevation index. OEO@muMN also attenuates the mean collagen area fraction and decreases the number of capillaries in scar tissues. Biochemical Assay reveals that OEO@muMN significantly inhibits the expression of transforming growth factor-β1 (TGF-β1) and hydroxyproline (HYP). In summary, this study demonstrates the feasibility and good efficacy of using the anti-proliferative and anti-oxidative OEO for HS treatment. OEO@muMN is an efficient formulation that holds the potential for clinical anti-HS application. muMN is an efficient platform to load and apply essential oils transdermally.

2024-08-21·Cureus

Evaluating the Depth of Penetration of Calcium Hydroxide Mixed With Three Different Herbal Essential Oils Using a Confocal Laser Scanning Microscope

Article

作者: Chandrasekaran, Charanya ; Sebatni, Anisha ; James, Vandna ; Kumar, Sarath ; Sundaresan, Balagopal ; Vidya, Venkat

Introduction The goal of endodontic therapy is to completely eliminate the infection and stop microbes from infecting or reinfecting the root canal and the periradicular tissues. Amongst the primary microorganisms, Enterococcus faecalis (E. faecalis), a Gram-positive anaerobe, is the main cause of pulpal and periapical inflammation causing root canal failure. Literature evidence shows that the gold-standard calcium hydroxide is ineffective against E. faecalis due to its resistance to the alkaline pH and proton pump mechanism. Herbal essential oils such as oregano, basil, and thyme are known to possess antimicrobial properties against E. faecalis. However, their combination with calcium hydroxide as an intracanal medicament and the depth of penetration is still unknown. Aim To evaluate the depth of penetration of calcium hydroxide mixed with three different herbal essential oils using a confocal laser scanning microscope. Material and methods Fifty single-rooted premolars were decoronated and randomly divided into five groups. Group 1 - Oregano oil with calcium hydroxide, Group 2 - Basil oil with Calcium hydroxide, Group 3 - Thyme oil with calcium hydroxide, Group 4 - Calcium hydroxide with saline, Group 5 - Negative control. The teeth were instrumented and inoculated with E. faecalis and incubated for 21 days. Calcium hydroxide mixed with respective oils or saline and 0.1% rhodamine B dye was placed in the canals and again incubated for 7 days. Two sections each of 1 mm were horizontally cut at 3 mm and 5 mm from the apex and later subjected to a confocal laser scanning microscope to evaluate the depth of penetration. One-way ANOVA, post-hoc Tukey test, and student t-test were performed. Results At the middle third, basil oil had the maximum depth of penetration (1377.47±14.1 µm) followed by oregano oil (1345.4±26.5 µm) and thyme oil (1160.4±24.6 µm). At apical third, basil oil (1152.4±31.6 µm) showed maximum depth of penetration, followed by thyme (988.3±26.2 µm) and oregano oils (419.5±19.8 µm). The depth of penetration of these oils was greater at the middle third than at the apical third. Conclusion Basil, oregano, and thyme oil have good penetration depth into the dentinal tubules and can be successfully used in root canal procedures as intracanal medicaments.

项与牛至提取物相关的新闻（医药）

2023-01-18

·PRNewswire

Worldwide Essential Oils Industry to 2027 - Increase in Demand for Aromatherapy Drives Growth

DUBLIN, Jan. 18, 2023 /PRNewswire/ -- The "Essential Oils Market By Product Type, Application (Food & beverages, Cosmetics & Toiletries, Aromatherapy, Home Care, and Health Care), Source (Fruits & Vegetables, Herbs & Spices, Flowers), Method of Extraction and Region - Global Forecast to 2027" report has been added to ResearchAndMarkets.com's offering. The global essential oils market size is estimated to be valued at USD 8.8 billion in 2022 and is projected to reach USD 15.3 billion by 2027, recording a CAGR of 11.8% in terms of value. By application, the aromatherapy is projected to grow rapidly during the forecast period The rising popularity of aromatherapy and other alternative medicine is increasing in demand, as are the relaxing effects of essential oils when applied through a massage. The health industry has begun to incorporate essential oils in aromatherapy applications to treat Alzheimer's, bronchitis, and various cardiovascular problems. Changing lifestyles and their consequences, such as high stress and depression, along with increasing disposable incomes, results in an increase in demand for aromatherapy. Ginger oil, pine oil, oregano oil, and wintergreen oil are some of the essential oils used on a large scale in alternative therapies. The National Association for Holistic Aromatherapy (NAHA), the Alliance of International Aroma Therapists, and The Canadian Federation of Aroma Therapists have established standards for aromatherapy certification in the US and Canada. This would allow the essential oil industry to use different oils for various aromatherapy products, globally. By type, the orange essential oil is widely used in all the domains due to the presence of the high amount of vitamin C and appealing fragrance Oranges are full of vitamin C and offer several health advantages. The rind of the sweet orange, Citrus sinensis, is used to make orange essential oil. Cold pressing, a technique used to extract the oils from the rind, is used to accomplish this. Brazil is the leading orange producer in the world producing about 30% of the world's output. Orange oil, which is energetic, is one of the most widely used options in aromatherapy. The oil can decrease various kinds of pain such as inflammation, muscle spasms, tissue damage, pain from bone fractures, headache, etc. The Asia Pacific market is being driven by an increase in demand for domestic products brought on by an expanding middle class The Asia Pacific region is mostly segmented into India, China, Japan, New Zealand, Australia, and Rest of Asia pacific. The improving standard of living and high per capita income in the region, along with higher expenditure, are driving up the demand for essential oils, which has been significantly influenced by the growth of the wellness and leisure sectors. The demand for citrus-based essential oils like orange and lemon has also attracted a lot of consumer interest in some of nations. The product is becoming more widely used in the personal care and household products sectors, and the usage of citrus essential oil in tastes, odorants, and pharmaceutical substances has lately increased. With emerging economies, growing industrialization, increasing demand for processed foods, and consumer preference for quality products, ingredient suppliers are becoming increasingly optimistic about the growth of the food & beverage industry. Key Topics Covered: 1 Introduction 2 Research Methodology 3 Executive Summary 4 Premium Insights 4.1 Attractive Opportunities for Players in Essential Oil Market 4.2 Essential Oils Market: Major Regional Submarkets 4.3 Asia-Pacific: Essential Oil Market, by Source & Country 4.4 Asia-Pacific: Essential Oil Market, by Application 4.5 Essential Oil Market, by Methods of Extraction 4.6 Essential Oil Market, by Application & Region 5 Market Overview 5.1 Introduction 5.2 Macroeconomic Indicators 5.2.1 Rise in Depression and Anxiety Disorders 5.2.2 Increasing Demand for Organic Food 5.3 Market Dynamics 5.3.1 Drivers 5.3.1.1 Increase in Demand for Aromatherapy 5.3.1.2 Increasing Demand for Natural Ingredients and Clean Label Products 5.3.1.3 Increased Use of Essential Oils in Homecare Products 5.3.1.4 Use of Essential Oils as an Additive in Feed 5.3.1.5 Demand for Essential Oils in Cosmetic & Fragrance Industry 5.3.2 Restraints 5.3.2.1 Depletion of Natural Resources 5.3.2.2 Side Effects Associated with Specific Essential Oils 5.3.3 Opportunities 5.3.3.1 Powdered Essential Oil to Create New Opportunities 5.3.4 Challenges 5.3.4.1 Prevalence of Synthetic/Adulterated Products 6 Industry Trends 6.1 Introduction 6.2 Value Chain 6.2.1 Research and Product Development 6.2.2 Raw Material Sourcing 6.2.3 Production 6.2.4 Packaging, Storage, and Distribution 6.2.5 End-Users 6.3 Supply Chain Analysis 6.4 Market Map and Ecosystem of Essential Oils Market 6.4.1 Demand Side 6.4.2 Supply Side 6.4.3 Ecosystem Map 6.5 Trends/Disruptions Impacting Customers' Businesses 6.5.1 Revenue Shift and New Revenue Pockets in Essential Oil Market 6.6 Technology Analysis 6.6.1 Ultrasonic Hydro Distillation 6.6.2 Pressurized Hot Water Extraction 6.6.3 Drying Technology 6.6.4 Encapsulation 6.7 Pricing Analysis 6.7.1 Selling Prices Charged by Key Players in Terms of Application 6.8 Essential Oils Market: Patent Analysis 6.8.1 List of Major Patents 6.9 Trade Analysis: Essential Oil Market 6.9.1 Export Scenario: Essential Oils for Citrus Fruits 6.9.2 Import Scenario: Citrus Fruit Essential Oils 6.9.3 Export Scenario: Essential Oils 6.9.4 Import Scenario: Essential Oils 6.10 Case Studies: Essential Oil Market 6.10.1 Rocky Mountain Oils: Sustainable Packaging 6.10.2 Doterra: Increase Operations Efficiency 6.11 Key Conferences and Events, 2022-2023 6.12 Tariff and Regulatory Landscape 6.12.1 Regulatory Bodies, Government Agencies, and Other Organizations 6.13 Porter's Five Forces Analysis 6.14 Key Stakeholders and Buying Criteria 7 Essential Oils Market, by Type 7.1 Introduction 7.2 Orange Oil 7.2.1 Increased Use in Aromatherapy 7.3 Peppermint Oil 7.3.1 Europe and Asia-Pacific to Have Significant Impact on Market 7.4 Lemon Oil 7.4.1 Rise in Demand for Nutraceuticals with Natural Flavor 7.5 Lavender Oil 7.5.1 Improves Skin Health 7.6 Lime Oil 7.6.1 Effective for Skin Infection Treatments 7.7 Rosemary Oil 7.7.1 Increased Usage in Healthcare Products due to Antioxidant Properties 7.8 Cornmint Oil 7.8.1 Powerful Antibacterial and Antiseptic Oil 7.9 Spearmint Oil 7.9.1 Extensively Used in Food & Beverage Industry as Flavoring Ingredient 7.10 Geranium Oil 7.10.1 Primary Floral Component in Fragrance and Cosmetics 7.11 Clove Leaf Oil 7.11.1 Used for Oral Health due to Germicidal Properties 7.12 Rose Oil 7.12.1 Widely Used in Aromatherapy 7.13 Coriander Oil 7.13.1 Use in Seasonings due to Flavoring Properties 7.14 Tea Tree Oil 7.14.1 Therapeutic Benefits to Increase Demand in Skincare and Cosmetics Industry 7.15 Citronella Oil 7.15.1 Large-Scale Use in Aromatherapy to Treat Migraine and Headaches 7.16 Eucalyptus Oil 7.16.1 High Demand in Dental Care due to Germicidal Properties 7.17 Jasmine Oil 7.17.1 Extensively Used for Health Benefits 7.18 Other Types 8 Essential Oils Market, by Method of Extraction 8.1 Introduction 8.2 Distillation 8.2.1 Steam Distillation Method Used Extensively to Obtain Essential Oils Economically 8.3 Cold Press Extraction 8.3.1 Citrus Fruits Extracted Via Cold Press 8.4 Carbon Dioxide Extraction 8.4.1 Aroma and Bioactive Components of Essential Oils Effectively Retained 8.5 Other Extractions 9 Essential Oils Market, by Source 9.1 Introduction 9.2 Fruits & Vegetables 9.2.1 Cold Press Method Preferred for Essential Oil Extraction from Fruits and Vegetable 9.3 Flowers 9.3.1 Essential Oils Represent an Upstream Business Opportunity for Floriculture Market 9.4 Herbs & Spices 9.4.1 Herb-Derived Essential Oils as Natural Replacers of Compounds of Synthetic Origin 10 Essential Oils Market, by Application 10.1 Introduction 10.2 Food & Beverages 10.2.1 Extensive Use of Citrus Essential Oils in Food & Beverage Industry 10.3 Cosmetics & Toiletries 10.3.1 Extensive Use of Essential Oils due to Fragrance and Functional Properties 10.4 Aromatherapy 10.4.1 Therapeutic Potential of Essential Oils 10.5 Homecare 10.5.1 Demand for Natural Ingredients to Boost Demand 10.6 Healthcare 10.6.1 Mental Well-Being to Drive Healthcare Industry 10.7 Other Applications 11 Essential Oils Market, by Region 12 Competitive Landscape 12.1 Overview 12.2 Market Share Analysis, 2021 12.3 Segmental Revenue Analysis of Key Players 12.4 Key Player Strategies 12.5 Company Evaluation Quadrant (Key Players) 12.5.1 Stars 12.5.2 Emerging Leaders 12.5.3 Pervasive Players 12.5.4 Participants 12.5.5 Product Footprint 12.6 Essential Oils Market, Evaluation Quadrant for Start-Ups/Smes, 2021 12.6.1 Progressive Companies 12.6.2 Starting Blocks 12.6.3 Responsive Companies 12.6.4 Dynamic Companies 12.6.5 Competitive Benchmarking of Key Start-Ups/Smes 12.7 Competitive Scenario 12.7.1 New Product Launches 12.7.2 Deals 12.7.3 Others 13 Company Profiles 13.1 Introduction 13.2 Key Player 13.2.1 Dsm 13.2.2 Givaudan 13.2.3 International Flavors & Fragrances Inc. (Iff) 13.2.4 Sensient Technologies Corporation 13.2.5 Cargill, Incorporated 13.2.6 Symrise 13.2.7 Robertet, Sa 13.2.8 Mane 13.2.9 Doterra 13.2.10 Now Foods 13.2.11 Synthite Industries Ltd. 13.2.12 Lebermuth, Inc. 13.2.13 Biolandes 13.2.14 Norex Flavours Private Limited 13.2.15 India Essential Oils 13.3 Other Players (Smes/Start-Ups) 13.3.1 Falcon 13.3.2 Farotti S.R.L. 13.3.3 Vidya Herbs 13.3.4 Young Living Essential Oils, Lc. 13.3.5 Essential Oils of New Zealand Ltd. 13.3.6 Veda Oils 13.3.7 Hcp Wellness 13.3.8 Vital Herbs 13.3.9 Cv Rasayana Wangi 13.3.10 Alchemy Chemicals 14 Adjacent & Related Markets 15 Appendix For more information about this report visit Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


WCD2023	临床3期	中度至重度痤疮	-	Encapsulated BPO 5% cream	(壓網願襯觸鑰築廠膚夢) = 憲網鏇遞襯襯網鑰糧築廠積餘範鹽膚構獵夢憲 (憲製襯壓顧構糧憲願蓋 )	-	2023-07-03
				Vehicle cream	(壓網願襯觸鑰築廠膚夢) = 艱鹹艱顧鬱顧窪鏇願餘廠積餘範鹽膚構獵夢憲 (憲製襯壓顧構糧憲願蓋 )
WCD2023	临床3期	玫瑰痤疮	733	E-BPO 5% cream	衊鬱觸選繭襯鹽網製鏇(願夢網憲憲範簾顧網膚) = 簾憲觸蓋範餘獵積顧獵簾顧衊築選選蓋憲淵鏇 (鹹鏇願膚繭鑰憲繭鑰遞 )	积极	2023-07-03
NCT02289989 (CTgov)	N/A	特应性皮炎	1	Hydrocortisone (Standard: Hydrocortisone 1% Ointment)	網壓餘襯範繭鏇鏇壓觸(憲衊壓膚觸鬱蓋窪鏇鹽) = 餘獵鹽繭齋夢鬱壓鹽積鹽艱遞蓋糧壓築願築窪 (鏇鬱觸淵選範廠餘獵膚, 蓋獵積衊製壓築選蓋簾 ~ 衊襯願範齋餘繭築願糧) 更多	-	2017-05-10
				Oregano extract cream (Experimental: Oregano Extract Cream)	鏇製範構築選積齋鑰齋(繭鹽簾餘齋顧鏇窪構遞) = 餘簾齋齋鹹遞膚衊顧積夢顧鹽顧餘構鑰齋壓壓 (醖衊蓋獵鹽遞窪壓糧鏇, 夢鏇鏇淵淵積齋膚構襯 ~ 夢窪構廠鏇艱顧齋選網) 更多