牛至提取物(Oregano extract) - _专利_临床

概要

基本信息

药物类型

中药

别名

Oregano extract cream

靶点-

作用方式-

作用机制-

治疗领域

免疫系统疾病遗传病与畸形皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

特应性皮炎

原研机构

Rutgers State University of New Jersey

在研机构

Washington State University

非在研机构

Rutgers State University of New Jersey

最高研发阶段早期临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与牛至提取物相关的临床试验

NCT06693960

/ Recruiting早期临床1期IIT

Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach

The purpose of this clinical trial is to determine how the supplement oregano affects how the body metabolizes pharmaceutical drugs.

开始日期2024-09-26

申办/合作机构

Washington State University

[+2]

NCT02289989

/ TerminatedN/AIIT

Investigator-Initiated, Randomized, Investigator-Blind, Half-Side Comparison of Topical Oregano Extract Ointment vs .Hydrocortisone 1% for the Treatment of Atopic Dermatitis in Pediatric Patients

This study is designed to evaluate and compare the efficacy of 3% oregano extract ointment prepared in aqueous solution versus 1% hydrocortisone ointment, a standard treatment, in decreasing the inflammation associated with mild to moderate atopic dermatitis. We plan to recruit 40 patients on the ages comprised between 2 and 17 years old and the study duration for each of the patient is 1 month.

开始日期2014-11-01

申办/合作机构

Rutgers State University of New Jersey

100 项与牛至提取物相关的临床结果

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100 项与牛至提取物相关的转化医学

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100 项与牛至提取物相关的专利（医药）

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89

项与牛至提取物相关的文献（医药）

2025-02-01·Annales de Cardiologie et d'Angéiologie

Origanum vulgare et risque hémorragique, à propos d'un cas

Article

作者: Belhachem, Abdelaali ; Hamidene, Imene ; Fendri, Allaoua Hicham ; Beghriche, Imene

INTRODUCTIONThe use of medicinal plants in Algeria is an ancestral practice that remains relevant today. The population relies on plants to treat various diseases and everyday ailments, which can be dangerous, especially when taking medication [1,2]. The interaction between plants and medication can lead to a modification of the plasma concentrations of the latter, which can impact its therapeutic effectiveness and be responsible for toxicity or therapeutic failure [1,2]. The interaction can also be pharmacodynamic, resulting in the potentiation of the effect or its antagonism. The risk is even higher when the medication has a narrow therapeutic range or presents high inter- or intra-individual variability, such as with vitamin K antagonist anticoagulants.CLINICAL CASEWe report the case of patient B.Z., aged 77, who is suffering from complete atrial fibrillation (ACFA). The patient has been under antivitamin K (AVK) treatment with acenocoumarol for 8 years and has been followed at the central laboratory of Didouche Mourad Hospital since August 2019. The patient has been stable with an INR within the therapeutic target range of 2-3 for 4 years. She is compliant and adheres to the dietary regimen. The dosage of acenocoumarol is alternated between 1/2 tablet and 1/4 tablet. On September 6, 2023, during a routine check-up, the patient's INR was 6.42, and the PT was 17.9%. The recommendation was to stop AVK and perform a control the following day. The interview revealed that the patient had started taking an infusion of oregano (Origanum vulgare), and occasionally verbena, at a rate of one 200 ml cup per day for a week. On September 7, 2023, the INR decreased to 3.80 and the PT to 26.9%, so the recommendation was to resume AVK at a dosage of 1/4 tablet to 1/2 tablet, with discontinuation of the herbal tea intake and an INR check after 72 hours. On the fourth day after resuming the anticoagulant, the INR was 2.5. Despite being informed of the risk of interaction, the patient resumed taking the freshly picked oregano herbal tea from her garden. Given the patient's determination to continue her infusion, the recommendation was made to limit her intake, to prepare much more diluted infusions, and to reduce the dose of acenocoumarol to 1/4 tablet; this allowed the stabilization of the patient's INR. The last check-up was performed on April 7, 2024, with an INR value of 2.3.RESULTSOregano, a plant from the Lamiaceae family, is used in herbal tea to treat a wide range of diseases, including joint pain, respiratory conditions, and digestive disorders. Similarly, verbena is also used to combat sleep disorders [2-4]. Origanum and verbena are both plants rich in polyphenols, as well as tannins and flavonoids. These substances are inhibitors of CYP 450, particularly CYP 2C9 and CYP 3A4, which are responsible for the metabolism of many drugs, including painkillers, antihypertensives, central nervous system drugs, and anticoagulants such as acenocoumarol. Origanum also exhibits anticoagulant activity due to its high content of carvacrol and thymol [4-6]. These two modes of interaction lead to an increase in the pharmacodynamic effect of acenocoumarol and, therefore, an increased risk of bleeding. This was the case for our patient, who saw her INR increase to more than twice the normal level, coinciding with the intake of oregano and verbena infusions, which normalized after their discontinuation.CONCLUSIONOregano is an endemic plant widely used in Algeria, whose anti-inflammatory properties are well established. However, its side effects, toxicity, and risk of interaction when combined with medications are less known. The interaction between oregano and AVK (acenocoumarol) exists and deserves to be recognized and monitored, especially in a population with a traditional culture where the use of plants is common. This practice should be accompanied by national phytovigilance.

2024-11-01·Veterinary Medicine and Science

Effects of cinnamon, rosemary and oregano on growth performance, blood biochemistry, liver enzyme activities, excreta microbiota and ileal morphology of Campylobacter jejuni‐challenged broiler chickens

Article

作者: Alimohammadi, Zahra ; Taherpour, Kamran ; Rahmatnejad, Enayat ; Khatibjoo, Ali ; Shirzadi, Hassan

AbstractBackgroundPhytogenic additives would be helpful to mitigate the detrimental impact of Campylobacter jejuni on broiler chickens.ObjectiveThe experiment aimed to assess the effects of cinnamon, rosemary and oregano powder on physiological responses of broiler chickens challenged with C. jejuni from 0 to 42 days of age.MethodsA total of 192 one‐day‐old male broiler chickens were divided into 6 treatment groups. The treatments included: negative control (NC; basal diet without additives and no C. jejuni challenge), positive control (PC; basal diet with C. jejuni challenge), PC with cinnamon, rosemary or oregano powder (3 g/kg each), and PC with Erythromycin (55 mg/kg). Except for the NC group, all chicks were orally challenged with 2 × 108 CFU/mL C. jejuni daily from days 21–25. Feed intake, body weight gain (BWG), feed conversion ratio (FCR), energy efficiency ratio (EER) and protein efficiency ratio (PER) were assessed during the rearing period (0–42 days). On day 42 of age, fresh excreta samples were collected from each pen to determine apparent dry matter digestibility and excreta microbiota. In addition, at the end of the experiment, blood samples were collected to evaluate blood profile and liver enzyme activities.ResultsC. jejuni challenge (PC treatment) decreased BWG, EER and PER, while increasing FCR of broiler chickens (p < 0.05), whereas rosemary, oregano and Erythromycin improved these performance parameters akin to NC. PC diet showed negative effect in ileal morphology, alleviated by additives except cinnamon (p < 0.05). Dietary additives successfully reduced Campylobacter levels and increased Lactobacilli counts in the PC. Rosemary and oregano lowered plasma total cholesterol (p < 0.05). Alanine aminotransferase elevation by C. jejuni challenge in the PC group was prevented by rosemary, oregano and Erythromycin (p < 0.05).ConclusionsOregano and rosemary alleviate the impact of C. jejuni challenge.

2024-08-21·Cureus

Evaluating the Depth of Penetration of Calcium Hydroxide Mixed With Three Different Herbal Essential Oils Using a Confocal Laser Scanning Microscope

Article

作者: Chandrasekaran, Charanya ; Sebatni, Anisha ; James, Vandna ; Kumar, Sarath ; Sundaresan, Balagopal ; Vidya, Venkat

Introduction The goal of endodontic therapy is to completely eliminate the infection and stop microbes from infecting or reinfecting the root canal and the periradicular tissues. Amongst the primary microorganisms, Enterococcus faecalis (E. faecalis), a Gram-positive anaerobe, is the main cause of pulpal and periapical inflammation causing root canal failure. Literature evidence shows that the gold-standard calcium hydroxide is ineffective against E. faecalis due to its resistance to the alkaline pH and proton pump mechanism. Herbal essential oils such as oregano, basil, and thyme are known to possess antimicrobial properties against E. faecalis. However, their combination with calcium hydroxide as an intracanal medicament and the depth of penetration is still unknown. Aim To evaluate the depth of penetration of calcium hydroxide mixed with three different herbal essential oils using a confocal laser scanning microscope. Material and methods Fifty single-rooted premolars were decoronated and randomly divided into five groups. Group 1 - Oregano oil with calcium hydroxide, Group 2 - Basil oil with Calcium hydroxide, Group 3 - Thyme oil with calcium hydroxide, Group 4 - Calcium hydroxide with saline, Group 5 - Negative control. The teeth were instrumented and inoculated with E. faecalis and incubated for 21 days. Calcium hydroxide mixed with respective oils or saline and 0.1% rhodamine B dye was placed in the canals and again incubated for 7 days. Two sections each of 1 mm were horizontally cut at 3 mm and 5 mm from the apex and later subjected to a confocal laser scanning microscope to evaluate the depth of penetration. One-way ANOVA, post-hoc Tukey test, and student t-test were performed. Results At the middle third, basil oil had the maximum depth of penetration (1377.47±14.1 µm) followed by oregano oil (1345.4±26.5 µm) and thyme oil (1160.4±24.6 µm). At apical third, basil oil (1152.4±31.6 µm) showed maximum depth of penetration, followed by thyme (988.3±26.2 µm) and oregano oils (419.5±19.8 µm). The depth of penetration of these oils was greater at the middle third than at the apical third. Conclusion Basil, oregano, and thyme oil have good penetration depth into the dentinal tubules and can be successfully used in root canal procedures as intracanal medicaments.

100 项与牛至提取物相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
特应性皮炎	临床1期	美国	Rutgers State University of New Jersey	2014-11-01

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临床结果

适应症

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


WCD2023	临床3期	中度至重度痤疮	-	Encapsulated BPO 5% cream	衊醖糧齋窪積餘蓋廠願(簾廠製壓窪壓網鏇齋積) = 夢構糧範願觸鏇糧衊網衊淵憲蓋壓築鹽簾簾襯 (餘夢齋膚襯築簾觸選簾 )	-	2023-07-03
				Vehicle cream	衊醖糧齋窪積餘蓋廠願(簾廠製壓窪壓網鏇齋積) = 積鏇襯鬱鹽憲獵鏇鹽鹹衊淵憲蓋壓築鹽簾簾襯 (餘夢齋膚襯築簾觸選簾 )
NCT02289989 (CTgov)	N/A	特应性皮炎	1	Hydrocortisone (Standard: Hydrocortisone 1% Ointment)	製窪鹹範鏇鏇積願膚壓(簾願構築願齋獵鹽窪夢) = 鹽齋選鹹顧憲糧遞艱繭顧構構蓋範膚鹽範選觸 (憲夢襯餘鹹憲顧壓鹹壓, 衊範淵壓廠餘衊夢製衊 ~ 蓋願遞選製鹽鑰糧膚鹽) 更多	-	2017-05-10
				Oregano extract cream (Experimental: Oregano Extract Cream)	遞範衊憲壓夢襯鹹鬱鬱(鏇壓齋鏇夢選積觸夢醖) = 顧膚鑰網範遞餘艱獵艱艱膚顧蓋鹽構衊醖簾顧 (襯齋觸觸構壓鏇觸糧餘, 構膚鬱構網構繭壓選製 ~ 獵襯窪艱齋繭顧齋膚築) 更多