Investigator-Initiated, Randomized, Investigator-Blind, Half-Side Comparison of Topical Oregano Extract Ointment vs .Hydrocortisone 1% for the Treatment of Atopic Dermatitis in Pediatric Patients

This study is designed to evaluate and compare the efficacy of 3% oregano extract ointment prepared in aqueous solution versus 1% hydrocortisone ointment, a standard treatment, in decreasing the inflammation associated with mild to moderate atopic dermatitis. We plan to recruit 40 patients on the ages comprised between 2 and 17 years old and the study duration for each of the patient is 1 month.

开始日期2014-11-01

申办/合作机构

Rutgers State University of New Jersey

100 项与牛至提取物相关的临床结果

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100 项与牛至提取物相关的转化医学

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100 项与牛至提取物相关的专利（医药）

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211

项与牛至提取物相关的文献（医药）

2024-01-19·Veterinary parasitology

Efficacy and safety of geranium-oregano-thymol formulations to control of dog tick Rhipicephalus sanguineus sensu lato under laboratory and field conditions.

Article

作者: Sahar M Gadelhaq ; Samar M Ibrahium ; Abdel-Azeem S Abdel-Baki ; Waleed M Arafa ; Saleh Al-Quraishy ; Ahmed O Hassan ; Noha H Abdelgelil ; Manal Ahmed ; Shawky M Aboelhadid

The present study evaluated, in laboratory and field, the efficacy and safety of formulations of Pelargonium graveolens (geranium - G), Origanum majorana (oregano - O) commercial essential oils (EO) and thymol (T) to control of Rhipicephalus sanguineus sensu lato. In the laboratory, three formulas (A: 2% tween 80%, B: powder and C: nanoemulsion) by a mixture of these components (GOT) were prepared and evaluated, and the best one was used to assess its safety and field application against R. sanguineus s. l. on naturally infested dogs. Besides the major compounds of the EO used were identified. The results of the lab study showed that formula A (2.5 g of each G + O + T + 2% tween 80 to complete 100 mL) was significantly more effective than the other two formulas tested and exhibited highly effective adulticidal, larvicidal, and ovicidal activity against R. sanguineus s.l. Significant LC₅₀ and LC₉₀ values of GOT were evaluated (13.4 and 21.5 mg/mL, respectively) for the adulticidal activity, (2.81 and 4.46 mg/mL, respectively) for ovicidal activity and (2.44 and 4.45 mg/mL, respectively) for larvicidal activity. The safety of formula A has been proven by the absence of its cytotoxicity on a cell line of human epidermoid carcinoma. Citronella and carvacrol were the major compounds identified in the commercial essential oils of P. graveolens and O. majorana, respectively. Formula A was used in a field control trial for almost 8 months, during the tick infestation season (April to November, 2022). Fourteen naturally infested dogs were divided into two groups, each with seven dogs. One group received formula A spraying five times during an experiment that continued for 8 months, while the other group received treatment with commercially available malathion acaricide. The animals were sprayed on five occasions throughout the experiment (April, June, July, August, and September). The results showed a substantial percentage of effectiveness after the first application of formula A with a 99.3% reduction in tick count at day 28 post-application (PA). In the case of severe infestation 60 days after the first application of formula A (more than 180 ticks per dog), the second application was done, achieving an efficacy of 54.9% at day 3 PA, so an emergency spray was done at day 5 PA to combat the rest of the tick infestation, achieving efficacy of 99% after 3 days. Consequently, a regular spray (third, fourth, and fifth application) was done every 35 days. This regular spray revealed 100% effectiveness at 14 days PA. Biochemical parameters of treated dogs were evaluated to confirm the safety of formula A. Creatinine, ALT, and albumin of the dogs treated with formula A were within the normal range of dogs, while urea and AST were higher than the normal range. In conclusion, formula A can safely treat R. sanguineus s.l. infestations in dogs with regular application every 5 weeks.

2024-01-17·Insects

Evaluation of the Potential Effect of Postbiotics Obtained from Honey Bees against Varroa destructor and Their Combination with Other Organic Products.

Article

作者: Eduardo José García-Vicente ; María Benito-Murcia ; María Martín ; Ismael Rey-Casero ; Ana Pérez ; María González ; Juan Manuel Alonso ; David Risco

The Varroa destructor mite infests Apis mellifera colonies and causes significant harm. Traditional treatments have become less effective because of mite resistance development and can also generate residues inside beehives. This study aimed to gauge the efficacy of a beehive-derived postbiotic in reducing V. destructor viability and to explore its synergies with organic compounds. Four lactic acid bacteria (LAB) species, Leuconostoc mesenteroides, Lactobacillus helsingborgensis, Bacillus velezensis, and Apilactobacillus kunkeei, were isolated and tested in a postbiotic form (preparations of inanimate microorganisms and/or their components) via bioassays. L. mesenteroides, L. helsingborgensis, and B. velezensis notably reduced the mite viability compared to the control, and they were further tested together as a single postbiotic product (POS). Further bioassays were performed to assess the impact of the POS and its combinations with oxalic acid and oregano essential oil. The simple products and combinations (POS/Oregano, POS/Oxalic, Oregano/Oxalic, and POS/Oregano/Oxalic) decreased the mite viability. The most effective were the oxalic acid combinations (POS/Oregano/Oxalic, Oxalic/Oregano, POS/Oxalic), showing significant improvements compared to the individual products. These findings highlight the potential of combining organic products as a vital strategy for controlling V. destructor infection. This study suggests that these combinations could serve as essential tools for combating the impact of mites on bee colonies.

2023-12-06·Animals : an open access journal from MDPI

Effects of Oregano Essential Oil on IgA⁺, IgG⁺, and IgM⁺ Cells in the Jejunum of Castrated Holstein Bulls.

Article

作者: Qiyan Liu ; Wangdong Zhang ; Baoshan Wang ; Jinping Shi ; Pengjia He ; Li Jia ; Yongliang Huang ; Meiling Xu ; Yue Ma ; Qiang Cheng ; Zhaomin Lei

The aim of this study was to investigate the effect of oregano essential oil on IgA⁺, IgG⁺, and IgM⁺ cells in the jejunum of castrated Holstein bulls. Twelve castrated Holstein bulls were randomly divided into control (YCK) and oregano essential oil (YEO) groups. Pathological changes in the jejunum were observed by HE staining, and the expression levels of IgA, IgG, and IgM in the jejunum were detected by ELISA. The distributions of IgA⁺, IgG⁺, and IgM⁺ cells in the jejunum were analysed by multiplex immunofluorescence and immunohistochemistry. The results showed that the jejunal villi were detached in the YCK group, which may have been related to inflammation, while the intestinal epithelium was clear and intact in the YEO group. The expressions of IgA, IgG, and IgM were significantly reduced by 40.75%, 30.76%, and 50.87%. The IgA⁺, IgG⁺, and IgM⁺ cells were diffusely distributed in the lamina propria of the jejunum, and were reduced by 17.07%, 6.44%, and 6.15%, respectively. Oregano essential oil did not alter the distribution characteristics of IgA⁺, IgG⁺, or IgM⁺ cells in the jejunum, but it suppressed inflammatory response, decreased immunoglobulin content, and significantly enhanced the formation of an immune barrier in the gastrointestinal mucosa.

项与牛至提取物相关的新闻（医药）

2023-01-18

·PRNewswire

Worldwide Essential Oils Industry to 2027 - Increase in Demand for Aromatherapy Drives Growth

DUBLIN, Jan. 18, 2023 /PRNewswire/ -- The "Essential Oils Market By Product Type, Application (Food & beverages, Cosmetics & Toiletries, Aromatherapy, Home Care, and Health Care), Source (Fruits & Vegetables, Herbs & Spices, Flowers), Method of Extraction and Region - Global Forecast to 2027" report has been added to ResearchAndMarkets.com's offering. The global essential oils market size is estimated to be valued at USD 8.8 billion in 2022 and is projected to reach USD 15.3 billion by 2027, recording a CAGR of 11.8% in terms of value. By application, the aromatherapy is projected to grow rapidly during the forecast period The rising popularity of aromatherapy and other alternative medicine is increasing in demand, as are the relaxing effects of essential oils when applied through a massage. The health industry has begun to incorporate essential oils in aromatherapy applications to treat Alzheimer's, bronchitis, and various cardiovascular problems. Changing lifestyles and their consequences, such as high stress and depression, along with increasing disposable incomes, results in an increase in demand for aromatherapy. Ginger oil, pine oil, oregano oil, and wintergreen oil are some of the essential oils used on a large scale in alternative therapies. The National Association for Holistic Aromatherapy (NAHA), the Alliance of International Aroma Therapists, and The Canadian Federation of Aroma Therapists have established standards for aromatherapy certification in the US and Canada. This would allow the essential oil industry to use different oils for various aromatherapy products, globally. By type, the orange essential oil is widely used in all the domains due to the presence of the high amount of vitamin C and appealing fragrance Oranges are full of vitamin C and offer several health advantages. The rind of the sweet orange, Citrus sinensis, is used to make orange essential oil. Cold pressing, a technique used to extract the oils from the rind, is used to accomplish this. Brazil is the leading orange producer in the world producing about 30% of the world's output. Orange oil, which is energetic, is one of the most widely used options in aromatherapy. The oil can decrease various kinds of pain such as inflammation, muscle spasms, tissue damage, pain from bone fractures, headache, etc. The Asia Pacific market is being driven by an increase in demand for domestic products brought on by an expanding middle class The Asia Pacific region is mostly segmented into India, China, Japan, New Zealand, Australia, and Rest of Asia pacific. The improving standard of living and high per capita income in the region, along with higher expenditure, are driving up the demand for essential oils, which has been significantly influenced by the growth of the wellness and leisure sectors. The demand for citrus-based essential oils like orange and lemon has also attracted a lot of consumer interest in some of nations. The product is becoming more widely used in the personal care and household products sectors, and the usage of citrus essential oil in tastes, odorants, and pharmaceutical substances has lately increased. With emerging economies, growing industrialization, increasing demand for processed foods, and consumer preference for quality products, ingredient suppliers are becoming increasingly optimistic about the growth of the food & beverage industry. Key Topics Covered: 1 Introduction 2 Research Methodology 3 Executive Summary 4 Premium Insights 4.1 Attractive Opportunities for Players in Essential Oil Market 4.2 Essential Oils Market: Major Regional Submarkets 4.3 Asia-Pacific: Essential Oil Market, by Source & Country 4.4 Asia-Pacific: Essential Oil Market, by Application 4.5 Essential Oil Market, by Methods of Extraction 4.6 Essential Oil Market, by Application & Region 5 Market Overview 5.1 Introduction 5.2 Macroeconomic Indicators 5.2.1 Rise in Depression and Anxiety Disorders 5.2.2 Increasing Demand for Organic Food 5.3 Market Dynamics 5.3.1 Drivers 5.3.1.1 Increase in Demand for Aromatherapy 5.3.1.2 Increasing Demand for Natural Ingredients and Clean Label Products 5.3.1.3 Increased Use of Essential Oils in Homecare Products 5.3.1.4 Use of Essential Oils as an Additive in Feed 5.3.1.5 Demand for Essential Oils in Cosmetic & Fragrance Industry 5.3.2 Restraints 5.3.2.1 Depletion of Natural Resources 5.3.2.2 Side Effects Associated with Specific Essential Oils 5.3.3 Opportunities 5.3.3.1 Powdered Essential Oil to Create New Opportunities 5.3.4 Challenges 5.3.4.1 Prevalence of Synthetic/Adulterated Products 6 Industry Trends 6.1 Introduction 6.2 Value Chain 6.2.1 Research and Product Development 6.2.2 Raw Material Sourcing 6.2.3 Production 6.2.4 Packaging, Storage, and Distribution 6.2.5 End-Users 6.3 Supply Chain Analysis 6.4 Market Map and Ecosystem of Essential Oils Market 6.4.1 Demand Side 6.4.2 Supply Side 6.4.3 Ecosystem Map 6.5 Trends/Disruptions Impacting Customers' Businesses 6.5.1 Revenue Shift and New Revenue Pockets in Essential Oil Market 6.6 Technology Analysis 6.6.1 Ultrasonic Hydro Distillation 6.6.2 Pressurized Hot Water Extraction 6.6.3 Drying Technology 6.6.4 Encapsulation 6.7 Pricing Analysis 6.7.1 Selling Prices Charged by Key Players in Terms of Application 6.8 Essential Oils Market: Patent Analysis 6.8.1 List of Major Patents 6.9 Trade Analysis: Essential Oil Market 6.9.1 Export Scenario: Essential Oils for Citrus Fruits 6.9.2 Import Scenario: Citrus Fruit Essential Oils 6.9.3 Export Scenario: Essential Oils 6.9.4 Import Scenario: Essential Oils 6.10 Case Studies: Essential Oil Market 6.10.1 Rocky Mountain Oils: Sustainable Packaging 6.10.2 Doterra: Increase Operations Efficiency 6.11 Key Conferences and Events, 2022-2023 6.12 Tariff and Regulatory Landscape 6.12.1 Regulatory Bodies, Government Agencies, and Other Organizations 6.13 Porter's Five Forces Analysis 6.14 Key Stakeholders and Buying Criteria 7 Essential Oils Market, by Type 7.1 Introduction 7.2 Orange Oil 7.2.1 Increased Use in Aromatherapy 7.3 Peppermint Oil 7.3.1 Europe and Asia-Pacific to Have Significant Impact on Market 7.4 Lemon Oil 7.4.1 Rise in Demand for Nutraceuticals with Natural Flavor 7.5 Lavender Oil 7.5.1 Improves Skin Health 7.6 Lime Oil 7.6.1 Effective for Skin Infection Treatments 7.7 Rosemary Oil 7.7.1 Increased Usage in Healthcare Products due to Antioxidant Properties 7.8 Cornmint Oil 7.8.1 Powerful Antibacterial and Antiseptic Oil 7.9 Spearmint Oil 7.9.1 Extensively Used in Food & Beverage Industry as Flavoring Ingredient 7.10 Geranium Oil 7.10.1 Primary Floral Component in Fragrance and Cosmetics 7.11 Clove Leaf Oil 7.11.1 Used for Oral Health due to Germicidal Properties 7.12 Rose Oil 7.12.1 Widely Used in Aromatherapy 7.13 Coriander Oil 7.13.1 Use in Seasonings due to Flavoring Properties 7.14 Tea Tree Oil 7.14.1 Therapeutic Benefits to Increase Demand in Skincare and Cosmetics Industry 7.15 Citronella Oil 7.15.1 Large-Scale Use in Aromatherapy to Treat Migraine and Headaches 7.16 Eucalyptus Oil 7.16.1 High Demand in Dental Care due to Germicidal Properties 7.17 Jasmine Oil 7.17.1 Extensively Used for Health Benefits 7.18 Other Types 8 Essential Oils Market, by Method of Extraction 8.1 Introduction 8.2 Distillation 8.2.1 Steam Distillation Method Used Extensively to Obtain Essential Oils Economically 8.3 Cold Press Extraction 8.3.1 Citrus Fruits Extracted Via Cold Press 8.4 Carbon Dioxide Extraction 8.4.1 Aroma and Bioactive Components of Essential Oils Effectively Retained 8.5 Other Extractions 9 Essential Oils Market, by Source 9.1 Introduction 9.2 Fruits & Vegetables 9.2.1 Cold Press Method Preferred for Essential Oil Extraction from Fruits and Vegetable 9.3 Flowers 9.3.1 Essential Oils Represent an Upstream Business Opportunity for Floriculture Market 9.4 Herbs & Spices 9.4.1 Herb-Derived Essential Oils as Natural Replacers of Compounds of Synthetic Origin 10 Essential Oils Market, by Application 10.1 Introduction 10.2 Food & Beverages 10.2.1 Extensive Use of Citrus Essential Oils in Food & Beverage Industry 10.3 Cosmetics & Toiletries 10.3.1 Extensive Use of Essential Oils due to Fragrance and Functional Properties 10.4 Aromatherapy 10.4.1 Therapeutic Potential of Essential Oils 10.5 Homecare 10.5.1 Demand for Natural Ingredients to Boost Demand 10.6 Healthcare 10.6.1 Mental Well-Being to Drive Healthcare Industry 10.7 Other Applications 11 Essential Oils Market, by Region 12 Competitive Landscape 12.1 Overview 12.2 Market Share Analysis, 2021 12.3 Segmental Revenue Analysis of Key Players 12.4 Key Player Strategies 12.5 Company Evaluation Quadrant (Key Players) 12.5.1 Stars 12.5.2 Emerging Leaders 12.5.3 Pervasive Players 12.5.4 Participants 12.5.5 Product Footprint 12.6 Essential Oils Market, Evaluation Quadrant for Start-Ups/Smes, 2021 12.6.1 Progressive Companies 12.6.2 Starting Blocks 12.6.3 Responsive Companies 12.6.4 Dynamic Companies 12.6.5 Competitive Benchmarking of Key Start-Ups/Smes 12.7 Competitive Scenario 12.7.1 New Product Launches 12.7.2 Deals 12.7.3 Others 13 Company Profiles 13.1 Introduction 13.2 Key Player 13.2.1 Dsm 13.2.2 Givaudan 13.2.3 International Flavors & Fragrances Inc. (Iff) 13.2.4 Sensient Technologies Corporation 13.2.5 Cargill, Incorporated 13.2.6 Symrise 13.2.7 Robertet, Sa 13.2.8 Mane 13.2.9 Doterra 13.2.10 Now Foods 13.2.11 Synthite Industries Ltd. 13.2.12 Lebermuth, Inc. 13.2.13 Biolandes 13.2.14 Norex Flavours Private Limited 13.2.15 India Essential Oils 13.3 Other Players (Smes/Start-Ups) 13.3.1 Falcon 13.3.2 Farotti S.R.L. 13.3.3 Vidya Herbs 13.3.4 Young Living Essential Oils, Lc. 13.3.5 Essential Oils of New Zealand Ltd. 13.3.6 Veda Oils 13.3.7 Hcp Wellness 13.3.8 Vital Herbs 13.3.9 Cv Rasayana Wangi 13.3.10 Alchemy Chemicals 14 Adjacent & Related Markets 15 Appendix For more information about this report visit Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

100 项与牛至提取物相关的药物交易

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研发状态

适应症	最高研发状态	国家/地区	公司
特应性皮炎	终止	美国更多	Rutgers State University of New Jersey 更多

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02289989 (CTgov)	N/A	特应性皮炎	1	Hydrocortisone (Standard: Hydrocortisone 1% Ointment)	淵繭選築觸夢選鹹鹽築(壓窪簾觸獵製繭構構蓋) = 夢繭簾範網獵鏇膚積夢夢糧憲壓積範選鏇淵蓋 (艱憲鹽鬱鬱鹽糧醖願觸, 膚範壓齋網齋鑰憲積餘 ~ 繭構製築夢鑰範醖艱製) 更多	-	2017-05-10
				Oregano extract cream (Experimental: Oregano Extract Cream)	廠範選鹽齋鹽蓋簾夢鏇(構餘範鹹願夢製憲窪醖) = 簾簾襯簾淵衊顧鏇餘顧繭積觸繭獵齋衊範淵餘 (鏇獵簾製積選衊餘鑰夢, 鹽憲艱襯簾網憲鹹築艱 ~ 積構選蓋積鏇範糧遞餘) 更多
WCD2023	临床3期	玫瑰痤疮	733	E-BPO 5% cream	蓋觸襯艱鹽積齋襯顧鑰(夢齋憲壓醖夢夢夢夢範) = 範觸顧積齋鬱膚願憲築鬱構製醖範選鏇網齋夢 (選齋鹹鑰廠襯網衊鑰膚 )	积极	2023-07-03
WCD2023	临床3期	中度至重度痤疮	-	Encapsulated BPO 5% cream	(膚糧襯壓憲衊願膚積觸) = 艱製蓋襯築鑰夢網膚憲壓獵窪繭壓鬱糧積簾獵 (淵製簾觸膚餘齋遞窪獵 )	-	2023-07-03
				Vehicle cream	(膚糧襯壓憲衊願膚積觸) = 醖糧糧範選繭鹹衊積製壓獵窪繭壓鬱糧積簾獵 (淵製簾觸膚餘齋遞窪獵 )