This is an open label, multi-center, phase II study of BBI503 administered to adult patients with advanced gastrointestinal stromal tumor who have exhausted all currently approved standard anti-cancer treatment options. BBI503 will be administered orally, daily, in continuous 28-day cycles at a dose of 300 mg once daily. Cycles will be repeated until patients are no longer clinically benefiting from therapy due to disease progression, adverse events, or another discontinuation criterion.
Safety, tolerability and efficacy of BBI503 will be assessed for the duration of study treatment.

开始日期2017-03-13

申办/合作机构

Sumitomo Pharma America, Inc.

NCT02232646 / Withdrawn临床2期

A Phase II Clinical Study of BBI503 in Adult Patients With Advanced Urologic Malignancies

This is an open label, multi-center, Phase II study of BBI503 administered to adult patients with selected advanced urologic malignancies. The primary objective of this study is to evaluate the disease control rate of patients with renal cell cancer and urothelial carcinoma treated with BBI503.

开始日期2017-01-01

申办/合作机构

Sumitomo Pharma America, Inc.

NCT02483247 / Completed临床1期

A Phase Ib/II Clinical Study of BBI503 in Combination With Selected Anti-Cancer Therapeutics in Adult Patients With Advanced Cancer

This is an open label, multi-center, Phase 1/2 study of BBI503 administered in combination with selected anti-cancer therapeutics in adult patients with advanced cancer. The goal of the study is to determine the safety, tolerability, and RP2D of BBI503 in combination with each of the selected anti-cancer agents.

开始日期2015-09-01

申办/合作机构

Sumitomo Pharma America, Inc.

100 项与 Amcasertib 相关的临床结果

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100 项与 Amcasertib 相关的转化医学

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100 项与 Amcasertib 相关的专利（医药）

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项与 Amcasertib 相关的文献（医药）

Medical Oncology

Cancer stemness kinase inhibitor amcasertib: a promising therapeutic agent in ovarian cancer stem and cancer cell models with different genetic profiles

Article

作者: Asik, Aycan ; Guler Kara, Hale ; Gunduz, Cumhur ; Ozates, Neslihan Pinar

Ovarian cancer, often referred to as the 'silent killer,' is a significant contributor to mortality rates. Emerging evidence implicates Nanog as a potential therapeutic target in ovarian cancer. Amcasertib (BBI-503) is an orally administered primary class stemness kinase inhibitor that effectively targets NANOG and various cancer stem cell pathways by specifically inhibiting serine-threonine stemness kinases. This study aimed to evaluate the antineoplastic effects of Nanog inhibition, a critical transcription factor associated with pluripotency and its role in ovarian cancer tumorigenesis, using the novel therapeutic agent Amcasertib in ovarian cancer cells characterized by distinct genetic profiles. The cytotoxicity of Amcasertib was assessed in both ovarian cancer and cancer stem cell models utilizing the Xelligence-RTCA system. The impact of the determined IC50 dose on apoptosis, invasion, migration, epithelial-mesenchymal transition (EMT), cell cycle progression, colony formation, and spheroid growth was evaluated using appropriate analytical techniques. Our findings revealed that Amcasertib exhibited significant antiproliferative effects and induced apoptosis in ovarian cancer and cancer stem cells. Moreover, Amcasertib caused G1 phase arrest and impeded colony formation in MDAH-2774 cells. Additionally, Amcasertib effectively inhibited spheroid growth in OVCAR-3 and OCSC cells. Notably, it demonstrated the ability to suppress invasion and migration in MDAH-2774 and OCSC cells. Furthermore, the suppression of Nanog-mediated stem cell-like features by Amcasertib was particularly pronounced in ER-negative ovarian cancer and cancer stem cells, highlighting its high anticancer efficacy in this subgroup. These results suggest that Amcasertib holds promise as a potential standalone or combination therapy agent for the treatment of ER-negative ovarian cancer.

100 项与 Amcasertib 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10903	-	-	DB14866

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肝细胞癌	临床3期	-	北京强新生物科技有限公司	-
卵巢癌	临床2期	美国	Sumitomo Dainippon Pharma Oncology, Inc.初创企业	2015-06-01
复发性卵巢癌	临床2期	美国	Sumitomo Pharma America, Inc.	2015-06-01
肝胆癌	临床2期	加拿大	Sumitomo Pharma America, Inc.	2015-02-01
胆管上皮癌	临床2期	-	Boston Biomedical Associates LLC	-
胆管上皮癌	临床2期	加拿大	Boston Biomedical, Inc.	-
肝细胞癌	临床2期	-	Boston Biomedical Associates LLC	-
肝细胞癌	临床2期	-	Boston Biomedical Associates LLC	-
肝细胞癌	临床2期	-	北京强新生物科技有限公司	-
胆管上皮癌	临床1期	-	北京强新生物科技有限公司	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01781455 (ASCO2017)	临床1/2期	腺样囊性癌	14	Amcasertib	(糧膚憲夢構獵蓋願積壓) = 積觸廠膚鬱蓋艱糧憲範積廠蓋選窪廠鏇選繭鹽 (廠衊製鏇醖鏇築範窪夢 ) 更多	-	2017-05-30
NCT01781455 (ASCO2017)	临床1/2期	晚期头颈癌	21	Amcasertib	(獵鹹淵繭醖膚鹹積簾膚) = 鏇鹽憲齋獵糧網鹽簾鹽餘鏇鏇衊衊簾選願蓋窪 (餘衊艱廠膚鬱遞夢製願 ) 更多	-	2017-05-30
NCD02279719 \| BBI608-503-103HCC (ASCO2017)	临床2期	肝细胞癌	20	Napabucasin (BBI608) + Sorafenib	(繭壓繭製顧憲顧憲鹹願) = 衊積憲觸醖鹹鬱繭願獵遞積遞製糧觸淵壓構觸 (膚鹹艱顧蓋鬱鏇遞襯艱 ) 更多	-	2017-05-30
NCD02279719 \| BBI608-503-103HCC (ASCO2017)	临床2期	肝细胞癌	20	Amcasertib (BBI503) + Sorafenib	(繭壓繭製顧憲顧憲鹹願) = 構鹽鹹廠選製衊窪夢繭遞積遞製糧觸淵壓構觸 (膚鹹艱顧蓋鬱鏇遞襯艱 ) 更多	-	2017-05-30
NCT02432690 (CTgov)	临床2期	复发性卵巢癌	13	BBI503	(製淵積網獵獵構獵構醖) = 繭蓋顧膚遞觸鹹鏇餘壓鬱艱窪襯淵築艱廠顧蓋 (壓齋製廠醖艱觸艱壓齋, 鏇蓋壓構獵簾窪願範醖 ~ 襯廠餘醖齋繭衊壓鹹壓) 更多	-	2022-08-29
NCT01781455 (ASCO2014)	临床1期	HR阳性/HER2低表达实体瘤	26	BBI503	(鹹鏇構繭襯餘觸淵廠網) = 鹽鏇淵觸夢獵選遞網製鬱襯簾膚齋憲餘繭積憲 (選鬱網膚製鏇顧觸網簾 ) 更多	-	2014-05-20
NCT01781455 (ASCO2016)	临床1期	晚期头颈癌	33	BB503	(製憲願簾膚網繭膚鑰壓) = Grade 3 AE included rapidly reversible diarrhea (n = 5) and nausea/vomiting (n = 1) 鹽積廠範獵蓋鏇鬱製鏇 (鑰襯製夢顧顧網獵簾膚 )	积极	2016-05-20
NCT01781455 (ASCO2015)	临床1期	晚期结直肠腺癌	47	BBI503 monotherapy	(糧網構顧積鬱憲艱醖窪) = 鬱窪範選襯鑰選窪製網衊齋淵繭顧選製鑰膚襯 (廠願夢築醖遞選鬱襯製 )	-	2015-05-20