Iscalimab

干燥综合征（SjD）是一种慢性全身性自身免疫病，主要表现为外分泌腺的淋巴细胞浸润，常伴有腺外表现。过去，SjD 的治疗选择仅限于缓解症状，而非针对病因治疗或阻止疾病进展。近年来，针对疾病潜在发病机制（循环 RNA 、B 细胞、T 细胞和相关受体、配体信号）的许多新型治疗策略不断涌现 [1]。 目前，欧洲风湿病学联盟（EULAR）[2] 和英国风湿病学会（BSR） [3]  的《干燥综合征管理指南》均建议在专业诊疗中心进行多学科护理，使用局部疗法缓解干燥症状并进行定期口腔护理，必要时采用全身治疗，同时将激素的使用时间缩短至所需的最短时长。尽管一些回顾性研究结果提示羟氯喹（HCQ）在治疗疲劳和全身性症状方面有一定益处，但来氟米特、甲氨蝶呤、硫唑嘌呤和霉酚酸酯等传统合成改善病情抗风湿药 (csDMARDs) 的使用缺乏大型 RCT 的支持。上述指南建议，对于严重、难治性全身性疾病，尤其是合并冷球蛋白血症性血管炎或作为恶性肿瘤化疗的辅助治疗时，可考虑利妥昔单抗等靶向 B 细胞耗竭疗法。 图 1. SjD 的治疗靶点[1] 过去 10 年，针对 SjD 的新型疗法有哪些？ （一）  随机对照（RCT）研究 [1] 1 靶向 B 细胞疗法 ✦ B 细胞耗竭 TEARS 研究（2014 年）结果发现接受两周内两次利妥昔单抗输注的患者在第 6、16 和 24 周时，干燥度、总体疾病活动度、疼痛或疲劳均未见改善。TRACTIS 试验（3 期；n=133）未发现利妥昔单抗治疗组与安慰剂组在第 48 周疲劳或口干 VAS 达到 30% 改善的主要终点方面存在统计学差异（OR 1.13；95% CI 0.50-2.55；p=0.76）。然而，Jousse-Joulin 等人的研究显示，第 24 周时，利妥昔单抗组 50%（7/14）的患者腮腺实质回声结构改善，而安慰剂组为 7%（1/14）（p=0.03）；Fisher 等人的研究显示，利妥昔单抗组的唾液腺复合超声总评分较安慰剂组显著改善，两项研究均发现腮腺回声结构和复合超声参数（如回声强度、均匀性、腺体边界、受累腺体和低回声灶大小）有统计学显著改善。 ✦ B 细胞活化因子受体阻断 Bowman 等人评估了通过 Ianalumab 在第 24 周时的疗效（n=190），发现 ESSDAI 降低了 1.92 分（95% CI -4.15-0.32；p=0.092）。Dorner 等人在其研究（n=27）中，同样发现 Ianalumab 治疗后 ESSDAI 评分存在改善。 2 靶向激酶、干扰素和 IL-6Ri ✦ 激酶类药物 Price 等人的 Ⅱ 期 RCT（n=150）评估了 Filgotinib、lanraplenib 和 tirabrutinib（分别为 JAK、SYK 和 BTK 信号抑制剂）的疗效。每种治疗的应答者定义为 CRP 水平改善 ≥ 20%，且在方案特定的复合改善标准（包括患者报告的总体疾病、疼痛、口干、眼干和疲劳症状的视觉模拟量表中至少 3 项改善）方面改善 ≥ 20%。第 12 周时，每种疗法均显示出轻微的非显著性获益，且治疗组的应答率均高于安慰剂组（Filgotinib 16.6%（95% CI 5.1-38.3；p=0.17）、lanraplenib 15.6%（95% CI 6.3-37.6；p=0.16）和 tirabrutinib 8.1%（95% CI 13.2-29.4；p=0.33）。 ✦ 干扰素信号传导 Posada 等人研究了 RNase-Fc 融合蛋白 RSLV-132（可降解 RNA 并抑制 IFNα 信号传导）的疗效（n=30），发现与安慰剂相比，疲劳评分平均显著降低了 1.53 分（p=0.04）。在第 99 天 ESSPRI 较基线平均降低了 1.22 分，安慰剂组平均降低 0.54 分（p=0.27）。  ✦ IL-6Ri Felten 等人在一项 Ⅱ 期 RCT（n=110）中研究了托珠单抗（IL-6 受体阻断剂）的疗效，第 24 周时未达到复合主要终点。托珠单抗应答率为 52.7%（29/55），而安慰剂组为 63.6%（35/55）（95% CI 30.6-74.2；p=0.14）。 3 靶向 B 细胞和 / 或 T 细胞相互作用的疗法 St Clair 等人开展的一项大规模（n = 183）且具有统计学显著结局的针对 CD40L 拮抗剂 Dazodalibep 的 RCT 研究结果提示队列 1（存在全身系统受累的患者）接受 Dazodalibep 治疗后，ESSDAI 平均（标准差）降低了 6.3 分（0.6），而安慰剂组降低了 4.1 分（0.6）（p=0.0167）。队列 2（症状严重但全身系统受累有限的患者）接受 Dazodalibep 治疗后，ESSPRI 平均（标准差）降低了 1.8 分（0.2），而安慰剂组降低了 0.5 分（0.2）（p=0.0002）。这是唯一一个在 RCT 中显示出对根据疾病表型分层的两类不同 SjD 人群均有显著益处的药物。 在阿巴西普的 Ⅲ 期 ASAP-III 试验中，第 24 周时治疗组 ESSDAI 评分较安慰剂组降低 1.3 分（95% CI -4.1-1.6；p = 0.385）。Fisher 等人通过 Ⅱ 期随机对照试验研究了 iscalimab（一种通过抗 CD40 / 154 共刺激通路抑制 B 细胞与 T 细胞相互作用的单克隆抗体）。iscalimab 组在第 12 周时 ESSDAI 评分较安慰剂组平均显著降低 5.21 分（95% CI 0.96-9.46；p = 0.0090）。 表：过去 10 年 SjD 治疗部分 RCT 结果 4 局部眼部疗法 Lin 等人的一项 RCT 比较了 0.1% 氟米龙糖皮质激素滴眼液与 0.5% 环孢素滴眼液的疗效，结果显示第 8 周时两组患者的角膜荧光素染色（CFS）评分显著改善（氟米龙组降低了 2.11±1.56，p<0.001；环孢素组降低了 2.50±1.71，p<0.001）。氟米龙组在泪膜破裂时间改善方面更优（第 8 周时氟米龙组延长 2.5 秒，环孢素组延长 1.5 秒，组间差异 1 秒，p=0.040），且结膜充血减轻速度更快（第 4 周时氟米龙组较基线结膜充血程度轻于环孢素组，p=0.035），但到第 8 周时两组间结膜充血程度无差异。 Moawad 等人的研究达到了他克莫司 0.03% 滴眼液对比环孢素 0.05% 滴眼液及安慰剂滴眼液的一个主要终点。第 180 天时，他克莫司组眼表疾病指数显著降低（他克莫司组降低 38.25±18.29%，环孢素组降低 31.69±18.57%；p = 0.09）。人工泪液使用频率减少量、眼表染色评分降低值、Schirmer 试验增加值等指标改善未达统计学显著性。至第 90 天时，他克莫司与环孢素组在减少人工泪液使用频率方面均较安慰剂组有统计学显著改善（他克莫司组 7.40±2.75 次 vs 安慰剂组 9.83±2.87 次，p=0.03；环孢素组 7.40±2.75 次 vs 安慰剂组 9.83±2.87 次，p=0.001）。两组在睑板腺分泌物质量或可挤压性评分方面均无变化 。 5 口干疗法 Da Mata 等人在一项 Ⅳ 期非安慰剂对照 RCT（n=110）中比较了苹果酸锭剂与柠檬酸漱口水的疗效，报告两组的口干量表评分较基线均有显著降低（苹果酸组降低 0.4 vs 柠檬酸组降低 0.1；p<0.05）。 6 其他疗法 在一项针对艾拉莫德的 RCT 研究（n=66）中，Shao 等人报告第 24 周时，艾拉莫德组的 ESSPRI 从 4.5±2.7 显著降至 3.0±1.2（p=0.024），而安慰剂组的 ESSPRI 从 4.2±2.4 降至 4.0±2.8（p=0.528）。 （二）  观察性研究 [1] De Vita 等人的研究显示，贝利尤单抗治疗第 52 周时疾病活动度降低（平均 ESSDAI 从 8.8（7.4）降至 6.3（6.6）；p=0.0001），ESSPRI 从平均 6.4（1.1）降至 5.6（2.0）（p=0.003）。Mariette 等人的研究表明，30 名患者中有 18 名（60%）在第 28 周时达到主要终点，即干燥度、疲劳、疼痛和全身活动度 VAS 评分中至少两项改善 ≥ 30%，且任何 B 细胞活化生物标志物改善 > 25%。Quartuccio 等人的研究显示，在 52 周贝利尤单抗试验治疗结束后，第 12 个月时 ESSDAI 从 3.5±3.7 升至 7.0±5.7（p=0.003）。 针对阿巴西普治疗 SjD 的 24 个月非随机、非安慰剂对照试验（n=11）显示，ESSDAI 显著降低，平均差异为 2.99（95% CI -0.49-7.99；p=0.013），非刺激性唾液流量增加（中位差异 0.90；95% CI -1.50-0.50；p=0.013）。 一项开放标签试点研究显示，全身性低剂量环孢素对 SjD 的关节症状有益，第 16 周时疼痛关节数减少（从 16.2±13.2 降至 10±11.9；p = 0.002），肿胀关节数减少（从 3.2±3.3 降至 1.3±3.2；p<0.001）。 Collins 等人的研究显示，羟氯喹在高症状负担的 SjD 亚组中具有益处，第 12 周时 ESSPRI 较安慰剂改善了 1.49 分（95% CI 0.54-2.43；p = 0.002）。一项回顾性研究（n=221）显示，羟氯喹可改善腺外表现（使用羟氯喹组 36.5% vs 接受其他疗法组 63.5%，p<0.001）。此外，有研究显示，羟氯喹与 SjD 患者的 ESSDAI 胸膜 - 肺部受累改善相关（使用羟氯喹组 6.7% vs 未使用羟氯喹组 14.9%；p = 0.01）。 关于霉酚酸酯的研究显示，在 SjD 相关 ILD 患者中，随着时间推移，肺功能指标得到改善，包括一氧化碳弥散量（DLCO）（治疗前每月下降 3.8%，治疗后每月下降 1.3%（p=0.01））和用力肺活量（FVC）（治疗前每月斜率变化 1.5%，治疗后每月 4.3%（p=0.02））。 局部眼部药物，如地夸磷索（一种刺激泪液和黏蛋白分泌的 P2Y2 嘌呤能受体激动剂）在 6 周内改善了泪膜破裂时间（TBUT）（基线时 1.72±1.03，治疗后 2.14±1.26，p=0.036）和眼部染色评分（OSS）（基线时 2.71±2.58，治疗后 2.03±2.38；p=0.005）。一项为期 12 个月的随访研究显示，由自体血清制成的富血浆生长因子滴眼液使平均 OSDI 降低了 41.86%（p<0.05），最佳矫正视力（BCVA）平均改善了 62.97%（p<0.05），症状频率视觉模拟量表降低了 34.75%（p<0.05），症状严重程度视觉模拟量表降低了 42%（p<0.05）。眼部局部应用环孢素使 OSDI 从 51.4±17.8 改善至 40.7±14.5（p<0.01），SICCA 眼部染色评分（OSS）从 7.55±1.71 改善至 6.35±1.81（p<0.01）。 Belbezier 等的一项回顾性研究显示，最初表现为无全身受累的 SjD 患者，早期接受免疫抑制治疗（定义为立即使用单药或联合用药物，  即硫唑嘌呤、甲氨蝶呤、来氟米特、霉酚酸酯、利妥昔单抗、贝利尤单抗、托珠单抗、阿巴西普或羟氯喹）的患者未进展为全身性疾病（24 例中 0 例），而未治疗组 40 例中有 11 例（27.5%）进展为全身受累（p<0.05）。 （三）  其他研究 嵌合抗原受体 T 细胞（CAR-T 细胞），通过工程改造自体患者 T 细胞以靶向和耗竭 B 细胞在自身免疫性疾病治疗中的应用也显示出潜力。一例病例报告表明，一名弥漫性大 B 细胞淋巴瘤患者接受抗 CD19 CAR-T 细胞治疗后，SjD 也获得了部分缓解 [4]。 北京大学人民医院何菁、栗占国教授团队 [5] 的一项入组 60 名 SjD 患者的 RCT 研究结果提示，24 周时，66.7% 的低剂量 IL-2 组患者达到研究主要终点 (ESSDAI 改善 >3)，显著高于安慰剂组的 26.7%（p=0.004)。且随着时间的推移，低剂量 IL-2 组患者的 ESSDAI 评分较安慰剂组改善更加显著 (p<0.001)。 今年 10 月底，中国医学科学院北京协和医院徐东、曾小峰教授团队关于泰它西普治疗 SjD 的中国 Ⅲ 期临床研究结果在 2025 年美国风湿病学会（ACR）年会公布 [6]。研究结果显示，第 24 周，泰它西普 160 mg 组 ESSDAI 评分较基线降低 4.3 分（P=0.002），且多个次要终点得到改善。 结语 目前 SjD 的管理仍存在很大挑战，但近年来围绕 SjD 的相关研究进展迅猛，药物研发日新月异，临床治疗效果显著提升，希望未来能有越来越多有效的药物，越来越多高证据等级的治疗药物，不断帮助提高 SjD 患者的生活质量及改善患者预后。 ✩ 本文仅供医疗卫生等专业人士参考 投稿邮箱：huanghaihua@dxy.cn 编辑：黄海花   题图来源：图虫创意 参考资料： [1] Pelkas C, Franke KB, Vincent FB, Rischmueller M. Novel therapies in Sjögren's disease: A systematic review of the literature. Best Pract Res Clin Rheumatol. 2025;39(4):102084. [2] Ramos-Casals M, Brito-Zeron P, Bombardieri S, Bootsma H, De Vita S, Dorner T, et al. EULAR recommendations for the management of Sjogren’s syndrome with topical and systemic therapies. Ann Rheum Dis 2020;79(1):3–18. [3] Price E, Allen A, Rauz S, Tappuni A, Sutcliffe N, Bombardieri M, et al. The management of Sjogren’s syndrome: British Society for Rheumatology guideline scope. Rheumatology 2021;60(5):2122–7. [4] Sheng L, Zhang Y, Song Q, Jiang X, Cao W, Li L, et al. Concurrent remission of lymphoma and Sjogren ¨ ’s disease following anti-CD19 chimeric antigen receptor-T cell therapy for diffuse large B-cell lymphoma: a case report. Front Immunol 2023;14:1298815. [5] He J, Chen J, Miao M, et al. Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(11):e2241451. Published 2022 Nov 1. doi:10.1001/jamanetworkopen.2022.41451 [6] Xu D, et al. Efficacy and Safety of Telitacicept in Patients with Sjögren’s Disease: Results from a Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Clinical Study. 2025 ACR Abstract Number: LB11.

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至11月29日15点59分，近期共有 465 本期刊发布了 910 篇文章，其中糖尿病相关的文章共 294 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 85 篇。今日，影响因子最高的文章刊登在 Journal of hematology & oncology (IF: 40.400) 期刊上。 今日头条 Headlines 01 Diabetes, obesity & metabolism IF: 05.700 生物类似胰岛素与参考胰岛素之间的治疗等效性和转换：一项随机对照试验的系统综述和荟萃分析 Xing, Xiaoxuan, Zhao, Lingyi, Wang, Ke, Wang, Zhizhou, Zhang, Lan, Dong, Xianzhe, etc. 近日，一项发表在Diabetes, obesity & metabolism期刊上的研究对生物类似胰岛素与参考胰岛素在糖尿病治疗中的等效性和转换进行了系统评估。该研究由Xing Xiaoxuan等人共同完成，旨在通过荟萃分析比较两者在疗效、安全性和免疫原性方面的差异，为临床实践提供证据支持。 研究检索了截至2025年3月的MEDLINE、Embase和Cochrane Library数据库，共纳入25项随机对照试验，涉及10617名患者。分析分为两部分：一是等效性试验，直接比较生物类似胰岛素与参考胰岛素；二是转换试验，患者在初始使用参考胰岛素后随机转换为生物类似胰岛素或继续使用参考胰岛素。主要结局指标包括糖化血红蛋白（HbA1c）变化、HbA1c<7%达标率、空腹血糖变化、不良事件和免疫原性。 结果显示，在等效性分析中，生物类似胰岛素与参考胰岛素在HbA1c变化上的均值差为0.01%（95% CI -0.04, 0.06），在转换分析中为-0.01%（95% CI -0.06, 0.05），均无统计学显著差异。此外，HbA1c<7%达标率的比值比在等效性分析中为0.99（95% CI 0.88, 1.12），在转换分析中为1.05（95% CI 0.86, 1.27），空腹血糖变化的均值差在等效性分析中为0.08 mmol/L（95% CI -0.06, 0.22），在转换分析中为0.11 mmol/L（95% CI -0.18, 0.40），均未显示显著差异。安全性和免疫原性方面，两组也无明显区别。 研究结论指出，生物类似胰岛素与参考胰岛素在关键疗效指标和主要安全性方面具有可比性，这为生物类似胰岛素在临床中的广泛应用提供了依据，有助于提高糖尿病治疗的可及性和成本效益。 本文由 牛祥 编辑 扫描二维码查看源文 Diabetes, obesity & metabolism | Ahead of Print. 10.1111/dom.70328 02 Diabetes Technol Ther IF: 06.300 Iscalimab在青少年和年轻成人新发1型糖尿病患者中的2期（2a）随机试验 Mathieu, Chantal, Quinlan, Michelle, Wagner, Kristina, Kompa, Jill, Hartmann, Nicole, Hughes, Maria F, etc. 一项针对青少年和年轻成人新发1型糖尿病的2期（2a）随机试验结果近日在Diabetes technology & therapeutics期刊上发表。该研究评估了Iscalimab，一种全人源化单克隆抗CD40抗体，在阻断CD154诱导的CD40信号通路中的作用，重点关注其安全性和对β细胞功能的影响。 研究在6个国家的14个中心进行，共纳入44名参与者，年龄范围为12至21岁，平均年龄16岁。参与者被随机分配至Iscalimab组或安慰剂组，比例为2:1，接受单次静脉注射后每周皮下注射治疗，持续一年。主要目的是评估治疗52周后的C-peptide曲线下面积（C-peptide AUC）变化，以及安全性指标。 结果显示，在52周时，Iscalimab组与安慰剂组在C-peptide AUC方面未观察到显著差异，比值为1.173。然而，C-peptide AUC的年变化率表明，Iscalimab组β细胞功能下降较慢，为-0.14 nmol/L每年，而安慰剂组为-0.33 nmol/L每年。此外，Iscalimab组在52周时的血红蛋白A1c水平估计几何平均比基线较低，为0.95，而安慰剂组为1.05。在免疫细胞方面，Iscalimab治疗导致白细胞、中性粒细胞和单核细胞水平较低，但T和B淋巴细胞水平较高。 安全性方面，Iscalimab显示出可接受的安全性和耐受性。治疗期间，Iscalimab组报告了5例严重不良事件，包括尿路感染、糖尿病代谢失代偿、创伤性骨折、低血糖和大肠感染，而安慰剂组报告了1例乳突炎。最常见的不良事件包括低血糖、鼻咽炎、注射部位反应、COVID-19和中性粒细胞减少，多数为轻度至中度，且已解决。研究期间，有7名参与者提前终止治疗，其中2例因COVID-19大流行期间试验暂停所致。 总体而言，这项研究表明Iscalimab在青少年新发1型糖尿病患者中具有可接受的安全性和耐受性，但由于样本量较小，疗效结果的解释受到限制。CD40:CD154抑制机制在1型糖尿病中的潜在作用值得进一步探索。 本文由 牛祥 编辑 扫描二维码查看源文 Diabetes Technol Ther | Ahead of Print. 10.1177/15209156251396115 03 Diabetology & metabolic syndrome IF: 03.900 血糖变异性在预测心血管疾病患者不良心血管事件风险中的预后作用：一项荟萃分析 Darouei, Bahar, Amani-Beni, Reza, Kakavand, Nasim, Seifnezhad, Arsham, Mazaheri-Tehrani, Sadegh, Shekarian, Arman, etc. 一项近期发表于Diabetology & metabolic syndrome期刊的荟萃分析，探讨了血糖变异性（GV）在心血管疾病患者预后中的预测价值。该研究由Darouei等人主导，文章ID为808593，旨在系统评估GV与不良心血管事件风险的关联。 研究背景指出，血糖变异性反映血糖波动，而增加GV已被观察到与不良心血管结局相关。为此，研究者通过系统检索PubMed、Embase、Scopus、Web of Science和CENTRAL等数据库，截至2025年5月，筛选出相关研究进行荟萃分析。 方法上，研究聚焦于已有心血管疾病的患者，GV通过平均血糖波动幅度（MAGE）和标准差（SD）测量。统计分析采用随机效应模型，并计算风险比（RR）和95%置信区间（CI），以评估GV与主要不良心血管事件（MACE）的关联。 结果显示，共纳入17项研究，涉及6096名患者。在分类分析中，更高的MAGE（RR: 2.18; 95% CI: 1.70, 2.80）和SD（RR: 1.94; 95% CI: 1.32, 2.87）均与MACE风险增加显著相关。连续分析进一步表明，MAGE与MACE风险增加相关（RR: 1.66; 95% CI: 1.28, 2.14），而连续SD分析未显示显著关联。 调整后的分析强化了MAGE的预测作用。元回归分析揭示，MAGE的cut-off阈值在效应大小中起显著调节作用。亚组分析显示，SD的关联因糖尿病状态而异，而MAGE的关联则受国家和随访时间影响。 证据确定性通过GRADE评估为非常低。在特定结局分析中，MAGE和SD与急性心力衰竭和心肌梗死风险增加相关，但与心血管死亡率无显著关联。 研究结论强调，血糖变异性，特别是通过MAGE评估，是已有心血管疾病患者心血管风险的显著预测因子。然而，由于观察性设计和潜在残留混杂因素，结果需谨慎解释。未来研究应致力于建立标准化阈值并探索剂量反应关系。 本文由 牛祥 编辑 扫描二维码查看源文 Diabetology & metabolic syndrome | Ahead of Print. 10.1186/s13098-025-02036-5 中国发表（85） China Communications medicine IF: 06.300Volume 5, Issue 1No.01Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNADOI: 10.1038/s43856-025-01220-y Communications medicine IF: 06.300Volume 5, Issue 1No.02Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetesDOI: 10.1038/s43856-025-01221-x Journal of hepatology IF: 33.000Ahead of Print.No.03A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infectionDOI: 10.1016/j.jhep.2025.11.017 J Infect Chemother IF: 01.500Ahead of Print.No.04Multi-biomarker Integration in Predicting Bedaquiline Treatment Response among Diabetic MDR-TB PatientsDOI: 10.1016/j.jiac.2025.102878 J Colloid Interface Sci IF: 09.700Ahead of Print.No.05Cu(2+)-Mediated membrane property modulation and aggregation of membranized coacervates for facilitating diabetic wound healingDOI: 10.1016/j.jcis.2025.139568 J Psychosom Res IF: 03.300Ahead of Print.No.06Trajectories of depressive symptoms and incident diabetes risk among middle-aged and older adults: A longitudinal cohort studyDOI: 10.1016/j.jpsychores.2025.112469 Scientific reports IF: 03.900Volume 15, Issue 1No.07Multi-omics exploration demonstrated the antidepressant effects of chrysophanol on diabetes-depression comorbidity rats via inflammatory, and neurodegenerative axesDOI: 10.1038/s41598-025-26745-z JCTR IF: 02.500Ahead of Print.No.08Correction: The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage AutophagyDOI: 10.1007/s12265-025-10710-2 European journal of radiology IF: 03.300Ahead of Print.No.09Integrated assessment of diabetic nephropathy by multi-parametric magnetic resonance imaging with non-enhanced T1 mapping, diffusion tensor imaging, and diffusion kurtosis imagingDOI: 10.1016/j.ejrad.2025.112578 European journal of pharmacology IF: 04.700Ahead of Print.No.10Empagliflozin alleviates iron accumulation and ferroptosis to mitigate bleomycin-induced pulmonary fibrosis through TFEB-mediated regulation of ACSL4 and GPX4恩格列净通过TFEB介导的ACSL4和GPX4调控减轻博来霉素诱导的肺纤维化中的铁积累和铁死亡DOI: 10.1016/j.ejphar.2025.178375 International journal of obesity IF: 03.800Ahead of Print.No.11Current evidence and future perspectives on magnet-assisted bariatric surgery (MABS): a systematic review磁辅助减重手术（MABS）的当前证据与未来展望：一项系统综述DOI: 10.1038/s41366-025-01966-4 Nature communications IF: 15.700Ahead of Print.No.12Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment鸟类GCGR介导的持续脂肪利用为肥胖治疗提供新视角DOI: 10.1038/s41467-025-66305-7 J Biol Chem IF: 03.900Ahead of Print.No.13Rab2A modulates liver fibroblast growth factor 21 (FGF21) expression and systemic metabolism via apolipoprotein B-CREBH signalingRab2A通过载脂蛋白B-CREBH信号通路调节肝脏成纤维细胞生长因子21表达和全身代谢DOI: 10.1016/j.jbc.2025.110977 Annals of hepatology IF: 04.400Ahead of Print.No.14Early-life exposure to tobacco smoke and chronic liver disease incidence in adulthood早期生命烟草暴露与成年期慢性肝病发病DOI: 10.1016/j.aohep.2025.102168 J Nutr Health Aging IF: 04.000Ahead of Print.No.15Osteosarcopenic obesity and the progression of physical frailty, cognition function, and mental health: First longitudinal evidence from ELSA骨质疏松性肌少症肥胖与身体衰弱、认知功能和心理健康进展的关系：来自ELSA的纵向证据DOI: 10.1016/j.jnha.2025.100744 Scientific reports IF: 03.900Ahead of Print.No.16TRPM4 expression predicts prognosis and modulates the immune microenvironment in pancreatic adenocarcinomaTRPM4表达预测胰腺腺癌的预后并调节免疫微环境DOI: 10.1038/s41598-025-30257-1 Obesity reviews IF: 07.400Ahead of Print.No.17Meteorin-Like Protein (Metrnl): An Exercise-Induced Myokine With Therapeutic Potential in Metabolic and Inflammatory Disorders类Meteorin蛋白（Metrnl）：一种运动诱导的肌因子在代谢和炎症性疾病中的治疗潜力DOI: 10.1111/obr.70046 Journal of nutrition IF: 03.800Ahead of Print.No.18Caloric Restriction Alleviates Anxiety-like Behaviors by Mitigating Neuroinflammation and Insulin Signaling Dysregulation in a High-Fat Diet-induced Obesity Mouse Model热量限制通过减轻神经炎症和胰岛素信号失调缓解高脂饮食诱导的肥胖小鼠模型的焦虑样行为DOI: 10.1016/j.tjnut.2025.11.013 Environment international IF: 09.700Ahead of Print.No.19Synergistic effects of bisphenol A and its substitutes with latent insulin resistance on childhood blood pressure and the potential role of lipid metabolism双酚A及其替代物与潜在胰岛素抵抗对儿童血压的协同效应及脂质代谢的潜在作用DOI: 10.1016/j.envint.2025.109951 Environment international IF: 09.700Ahead of Print.No.20Early pregnancy blood heavy metal(loid)s and low sea-fish consumption in relation to risk of gestational diabetes mellitus among Shanghai Birth cohort (SBC) women孕早期血液重金属(类)和低海鱼摄入与Shanghai Birth cohort (SBC)女性妊娠期糖尿病风险的关系DOI: 10.1016/j.envint.2025.109959 Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.21Associations of phthalates and metal(loid)s co-exposure with abdominal obesity indices in Shenzhen, China中国深圳地区邻苯二甲酸酯和金属(类)共同暴露与腹型肥胖指标的关联DOI: 10.1016/j.ecoenv.2025.119475 Science advances IF: 12.500Volume 11, Issue 48No.22Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects力学适应性多糖共轭物通过动态应力再分布在皮肤缺陷中构建促愈合微环境DOI: 10.1126/sciadv.adz3529 J Investig Med IF: 02.000Ahead of Print.No.23EXPRESS: Gabapentin in Chronic Cough Treatment: Meta-Analysis Insights加巴喷丁在慢性咳嗽治疗中的应用：荟萃分析见解DOI: 10.1177/10815589251406268 Psychology, health & medicine IF: 01.900Ahead of Print.No.24The relationship between bedtime procrastination and high risk for obstructive sleep apnea syndrome in the youth population睡前拖延与青年人群阻塞性睡眠呼吸暂停综合征高风险之间的关系DOI: 10.1080/13548506.2025.2594762 Obesity surgery IF: 03.100Ahead of Print.No.25"Not Hungry, Yet Always Wanting To Eat": Perceptions and Experiences of Grazing Behavior in Post-Metabolic and Bariatric Surgery Patients - A Qualitative Study"不饿，却总想吃"：减重手术后患者对放牧行为的认知和体验——一项定性研究DOI: 10.1007/s11695-025-08375-6 J Investig Med IF: 02.000Ahead of Print.No.26EXPRESS: Association of C-reactive Protein-to-Lymphocyte Ratio with Depression: A Mediating Effect of Weight-adjusted Waist IndexEXPRESS: C反应蛋白与淋巴细胞比值与抑郁症的关联：体重调整腰围指数的中介效应DOI: 10.1177/10815589251406271 Ophthalmic epidemiology IF: 01.200Ahead of Print.No.27Global, Regional, and National Burden of Early-Onset Cataract from 1990 to 2021: Findings from the Global Burden of Disease Study 20211990年至2021年全球、区域和国家早发性白内障负担：来自2021年全球疾病负担研究的发现DOI: 10.1080/09286586.2025.2587606 Int J Oncol IF: 04.900Volume 68, Issue 1No.28Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)肥胖、慢性乳腺炎症与癌变：分子通路与临床意义DOI: 10.3892/ijo.2025.5825 J Sci Food Agric IF: 03.500Ahead of Print.No.29Antioxidative stress effect of chromium-chelated pea (Pisum sativum L.) peptides through the Keap1/Nrf2 pathway铬螯合豌豆肽通过Keap1/Nrf2通路的抗氧化应激效应DOI: 10.1002/jsfa.70293 Cardiovascular Drugs and Therapy IF: 03.100Ahead of Print.No.30Therapeutic Potential of Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles in Atherosclerotic Stenosis and Endothelial Dysfunction骨髓间充质干细胞来源的细胞外囊泡在动脉粥样硬化性狭窄和内皮功能障碍中的治疗潜力DOI: 10.1007/s10557-025-07818-7 Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.31Safety profile of olanzapine/samidorphan: focus on metabolic risks, opioid-related effects, and novel adverse events identified奥氮平/萨米多芬的安全性概况：聚焦于代谢风险、阿片类相关效应及新型不良事件DOI: 10.1007/s00210-025-04818-0 Medicina IF: 00.600Volume 85, Issue 6No.32Time and departments of consultation affecting pyogenic liver abscess diagnosis咨询时间与科室对化脓性肝脓肿诊断的影响https://pubmed.ncbi.nlm.nih.gov/41313105 Ginekologia Polska IF: 01.000Ahead of Print.No.33Integrated chromosomal microarray analysis and whole-exome sequencing in prenatal diagnosis of congenital hearts disease with maternal diabetes: a novel insight into gene environment interaction整合染色体微阵列分析和全外显子组测序在孕前诊断母体糖尿病相关先天性心脏病中的应用：基因环境相互作用的新见解DOI: 10.5603/gpl.106256 Frontiers in physiology IF: 03.400Volume 16, Issue No.34Mechanisms of metabolic transition in hypertrophic cardiomyopathy肥厚型心肌病中的代谢转变机制DOI: 10.3389/fphys.2025.1700313 Frontiers in medicine IF: 03.000Volume 12, Issue No.35Intranasal insulin and postoperative delirium in adult surgical patients: a meta-analysis and systematic review of randomized controlled trials鼻内胰岛素与成人手术患者术后谵妄：随机对照试验的荟萃分析和系统评价DOI: 10.3389/fmed.2025.1670982 Frontiers in medicine IF: 03.000Volume 12, Issue No.36Hepatic encephalopathy due to non-cirrhotic portal hypertension associated with non-alcoholic steatohepatitis and chronic hepatitis B: a Case Report非酒精性脂肪性肝炎和慢性乙型肝炎相关非肝硬化性门脉高压所致肝性脑病：一例报告DOI: 10.3389/fmed.2025.1576827 Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.37Deciphering the significant impact of natural glycosylation on human insulin揭示天然糖基化对人胰岛素的显著影响DOI: 10.1016/j.apsb.2025.08.005 Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.38Association between changes in estimated glucose disposal rate and composite kidney outcome in middle-aged and elderly individuals: a national cohort study估计葡萄糖利用率变化与中老年人复合肾脏结局的关联：一项全国队列研究DOI: 10.1186/s13098-025-02028-5 BMC cancer IF: 03.400Ahead of Print.No.39Association of estimated glucose disposal rate with all-cause and breast cancer-specific mortality in US breast cancer survivors: a population-based study估计葡萄糖利用率与美国乳腺癌幸存者全因和乳腺癌特异性死亡率的关联：一项基于人群的研究DOI: 10.1186/s12885-025-15340-0 J Diabetes Investig IF: 03.000Ahead of Print.No.40Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization基于两样本孟德尔随机化的循环白细胞特征与糖尿病视网膜病变的因果关联DOI: 10.1111/jdi.70196 Frontiers in neurology IF: 02.800Volume 16, Issue No.41Research progress on risk factors for in-stent restenosis following cerebrovascular stent implantation脑血管支架植入术后支架内再狭窄风险因素的研究进展DOI: 10.3389/fneur.2025.1660202 Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.42Metabolomics and Gut Microbiota in Elderly Patients with Diabetic Peripheral Neuropathy and Sarcopenia老年糖尿病周围神经病变与肌少症患者的代谢组学与肠道菌群研究DOI: 10.2147/DMSO.S537792 Materials today bio IF: 10.200Volume 35, Issue No.43Highly stretchable and conductive liquid metal-based multifunctional organohydrogel for behavior monitoring and chronic diabetic wounds treatment高度可拉伸和导电的液态金属基多功能有机水凝胶用于行为监测和慢性糖尿病伤口治疗DOI: 10.1016/j.mtbio.2025.102507 Front Bioeng Biotechnol IF: 04.800Volume 13, Issue No.44Finite element analysis of biomechanical effects in rat tibia during tibial cortex transverse transport大鼠胫骨皮质横向转运过程中生物力学效应的有限元分析DOI: 10.3389/fbioe.2025.1670040 Frontiers in pharmacology IF: 04.800Volume 16, Issue No.45Correction: Renoprotective effects of GHRH agonist MR409 is associated with reduced oxidative stress and ferroptosis in diabetic mice更正：GHRH激动剂MR409的肾脏保护作用与糖尿病小鼠中氧化应激和铁死亡减少相关DOI: 10.3389/fphar.2025.1737333 Int J Gen Med IF: 02.000Volume 18, Issue No.46Glycosylation-Related Genes and Prognostic Signatures in Diabetic Nephropathy糖尿病肾病中糖基化相关基因及预后标志物DOI: 10.2147/IJGM.S545376 Genes & diseases IF: 09.400Volume 13, Issue 2No.47Deficiency of TMEM16F in hair cells prevents diabetes-related and noise-induced hearing loss毛细胞中TMEM16F缺陷预防糖尿病相关和噪音诱导的听力损失DOI: 10.1016/j.gendis.2025.101708 Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.48Brain endothelial HIF-1α exacerbates diabetes-associated cognitive impairment by accelerating glycolysis-driven lactate production脑内皮HIF-1α通过加速糖酵解驱动的乳酸产生加剧糖尿病相关认知障碍DOI: 10.1016/j.apsb.2025.09.028 Journal of materials chemistry IF: 05.700Ahead of Print.No.49Evaluation of the anti-thrombosis efficacy of MPC-based copolymer coatings in high coagulation risk blood评估MPC基共聚物涂层在高凝血风险血液中的抗血栓形成有效性DOI: 10.1039/d5tb01941a Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.50Therapeutic equivalence and switching between biosimilar and reference insulins: A systematic review and meta-analysis of randomised controlled trials生物类似胰岛素与参考胰岛素之间的治疗等效性和转换：一项随机对照试验的系统综述和荟萃分析DOI: 10.1111/dom.70328 Eur J Med Res IF: 03.400Ahead of Print.No.51Neutrophil percentage to albumin ratio and advanced cardiovascular-kidney-metabolic syndrome in diabetes: a machine learning approach中性粒细胞百分比与白蛋白比值与糖尿病晚期心血管-肾脏-代谢综合征：机器学习方法DOI: 10.1186/s40001-025-03560-w BMC public health IF: 03.600Ahead of Print.No.52Fasting plasma glucose trajectories are associated with ischemic stroke in the elderly: a longitudinal study using group-based trajectory modeling in Chinese communities空腹血糖轨迹与老年人缺血性卒中相关：一项基于中国社区的纵向研究使用组基轨迹建模DOI: 10.1186/s12889-025-25773-8 BMC oral health IF: 03.100Ahead of Print.No.53p75NTR alleviates diabetic periodontitis in mice by inhibiting inflammatory macrophage recruitmentp75NTR通过抑制炎症性巨噬细胞募集缓解小鼠糖尿病性牙周炎DOI: 10.1186/s12903-025-07220-7 BMC Complement Med Ther IF: 03.400Ahead of Print.No.54Efficacy and safety of tangweian recipe in the treatment of diabetic gastroparesis: a protocol for a non-inferiority, double-blind, active drug, randomized controlled clinical trial汤胃安方治疗糖尿病胃轻瘫的有效性和安全性：一项非劣效性、双盲、活性药物、随机对照临床试验方案DOI: 10.1186/s12906-025-05104-5 The EPMA journal IF: 05.900Volume 16, Issue 4No.55Enhancing cardiovascular risk prediction in hypertensive adults: a 3PM-based evaluation of insulin resistance and arterial stiffness增强高血压成人心血管风险预测：基于3PM的胰岛素抵抗和动脉僵硬度评估DOI: 10.1007/s13167-025-00421-8 Eur J Med Res IF: 03.400Ahead of Print.No.56Association of C-reactive protein-triglyceride glucose index with anxiety in American adults: outcomes from NHANES 2007 to 2010C-反应蛋白-甘油三酯葡萄糖指数与美国成年人焦虑的关联：来自NHANES 2007至2010的结果DOI: 10.1186/s40001-025-03555-7 iScience IF: 04.100Volume 28, Issue 11No.57Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism黄芩素富集的Roseburia hominis通过上调亚麻酸代谢逆转二甲双胍无反应性DOI: 10.1016/j.isci.2025.113892 The EPMA journal IF: 05.900Volume 16, Issue 4No.58Repurposing holistic effects of metformin from diabetes management to skin wound healing: a 3PM-guided innovation二甲双胍从糖尿病管理到皮肤伤口愈合的整体效应再利用：3PM指导的创新DOI: 10.1007/s13167-025-00430-7 Therapeutic advances in urology IF: 03.500Volume 17, Issue No.59BMI mediates the association between red cell distribution width to serum albumin index and kidney stone risk: a population-based studyBMI介导红细胞分布宽度与血清白蛋白比值指数与肾结石风险之间的关联：一项基于人群的研究DOI: 10.1177/17562872251397201 Frontiers in public health IF: 03.400Volume 13, Issue No.60Eating habits, nutritional status, and lifestyle correlates of body composition in Chinese university students: a cross-sectional study饮食习惯、营养状况和生活方式与中国大学生身体成分的相关性：一项横断面研究DOI: 10.3389/fpubh.2025.1668307 Frontiers in public health IF: 03.400Volume 13, Issue No.61Psychometric evaluation of the Adult Eating Behavior Questionnaire and its relationship with body mass index among Chinese university students: a cross-sectional validation study成人饮食行为问卷在中国大学生中的心理测量评估及其与体重指数的关系：一项横断面验证研究DOI: 10.3389/fpubh.2025.1691302 Obesity medicineVolume 53, Issue No.62Long-term Management of Obesity in Adult Patients成人肥胖症的长期管理DOI: 10.1016/j.obmed.2024.100580 Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.63Amino acid restriction in obesity management: Inducing energy discharge氨基酸限制在肥胖管理中的应用：诱导能量耗散DOI: 10.1016/j.apsb.2025.07.013 Eur J Med Res IF: 03.400Ahead of Print.No.64Associations between sex hormones and obesity-related indicators: results from the NHANES and Mendelian randomization study性激素与肥胖相关指标之间的关联：NHANES和孟德尔随机化研究结果DOI: 10.1186/s40001-025-03470-x Eur J Med Res IF: 03.400Ahead of Print.No.65Prognostic significance of postoperative glycemic variability after gastric surgery: a retrospective cohort study and development of a mortality prediction model胃手术后术后血糖变异性的预后意义：一项回顾性队列研究及死亡率预测模型的开发DOI: 10.1186/s40001-025-03501-7 Breast cancer research IF: 05.600Volume 27, Issue 1No.66Macrophages in obesity-related breast cancer: mechanistic insights and therapeutic opportunities肥胖相关乳腺癌中的巨噬细胞：机制见解与治疗机会DOI: 10.1186/s13058-025-02155-x BMC public health IF: 03.600Volume 25, Issue 1No.67Correction: Implementation research on the intervention mode of "Comorbidity-Co-causes-Joint-prevention" comprehensive demonstration district of depression and obesity among children and adolescents in Beijing: study protocol更正：北京儿童青少年抑郁与肥胖‘Comorbidity-Co-causes-Joint-prevention’综合示范区干预模式实施研究：研究方案DOI: 10.1186/s12889-025-25552-5 BMC public health IF: 03.600Volume 25, Issue 1No.68The influence of adiposity status and the trajectories of obesity indicators on earlier puberty onset in girls: a longitudinal cohort study in Shanghai, China肥胖状态和肥胖指标轨迹对女孩较早青春期启动的影响：一项在中国上海的纵向队列研究DOI: 10.1186/s12889-025-25122-9 Nanfang Yike Daxue xuebaoVolume 45, Issue 11No.69[Silencing DDX17 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in vitro by decreasing mTORC1 activity]沉默DDX17通过降低mTORC1活性抑制肺动脉平滑肌细胞的体外增殖和迁移DOI: 10.12122/j.issn.1673-4254.2025.11.20 J Multidiscip Healthc IF: 02.400Volume 18, Issue No.70Combined Auricular Acupoint Pressing and Intradermal Acupuncture for Insomnia and Glycemic Control in Elderly Patients with Type 2 Diabetes: A Retrospective Study耳穴贴压联合皮内针治疗老年2型糖尿病患者失眠和血糖控制的回顾性研究DOI: 10.2147/JMDH.S538807 Drug Des Devel Ther IF: 05.100Volume 19, Issue No.71The Clinical Application of GLP-1RAs and GLP-1/GIP Dual Receptor Agonists Based on Pharmacological Mechanisms: A Review基于药理机制的GLP-1受体激动剂和GLP-1/GIP双受体激动剂的临床应用：综述DOI: 10.2147/DDDT.S559919 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.72Association of the neutrophil-to-lymphocyte ratio with sudden cardiac death in the patients with diabetic foot ulcer中性粒细胞与淋巴细胞比值与糖尿病足溃疡患者心源性猝死的关联DOI: 10.3389/fendo.2025.1697718 Am J Ophthalmol Case RepVolume 40, Issue No.73Optic disc edema during semaglutide therapy: case report and literature review司美格鲁肽治疗期间视盘水肿：病例报告及文献回顾DOI: 10.1016/j.ajoc.2025.102476 Frontiers in microbiology IF: 04.500Volume 16, Issue No.74Short-chain fatty acids and type 2 diabetes: a bibliometric analysis of knowledge structure, research hotspots, and future directions短链脂肪酸与2型糖尿病：知识结构、研究热点与未来方向的文献计量分析DOI: 10.3389/fmicb.2025.1697421 Journal of medical case reports IF: 00.900Ahead of Print.No.75Clinical analysis of non-ketotic hyperglycemia with reversible cortical blindness: a case report非酮症高血糖伴可逆性皮质盲的临床分析：一例报告DOI: 10.1186/s13256-025-05184-4 BMC endocrine disorders IF: 03.300Ahead of Print.No.76Triglyceride-glucose index in diabetic chronic complications in patients with type 2 diabetes mellitus甘油三酯-葡萄糖指数在2型糖尿病患者糖尿病慢性并发症中DOI: 10.1186/s12902-025-02101-0 Acta pharmaceutica sinica B IF: 14.600Volume 15, Issue 11No.77High glucose induces hippocampal neuron impairment through the SKP1/COX7C pathway: A potential mechanism for perimenopausal depression高糖通过SKP1/COX7C通路诱导海马神经元损伤：围绝经期抑郁症的潜在机制DOI: 10.1016/j.apsb.2025.09.003 The EPMA journal IF: 05.900Volume 16, Issue 4No.78Multivariable data-driven framework of predictive, preventive, and personalized medicine for long-term atrial fibrillation risk in patients with new-onset obstructive sleep apnea基于多变量数据驱动的预测性、预防性和个性化医学框架用于新发阻塞性睡眠呼吸暂停患者长期心房颤动风险评估DOI: 10.1007/s13167-025-00422-7 Cardiovascular Diabetology IF: 10.600Volume 24, Issue 1No.79Plasma inflammatory proteome profiles identify MASLD among children with overweight or obesity血浆炎症蛋白质组谱识别超重或肥胖儿童中的MASLDDOI: 10.1186/s12933-025-03011-0 Frontiers in nutrition IF: 05.100Volume 12, Issue No.80Different association between triglyceride-glucose index and mild cognitive impairment in type 2 diabetes mellitus patients with and without diabetic kidney disease甘油三酯-葡萄糖指数与2型糖尿病患者轻度认知障碍的不同关联：有无糖尿病肾病的比较DOI: 10.3389/fnut.2025.1681164 Journal of diabetes research IF: 03.400Volume 2025, Issue No.81TangNaikang Formula Alleviates Podocyte Injury in Diabetic Nephropathy by Modulating the SHIP2/PI3K/AKT PathwayTangNaikang方通过调节SHIP2/PI3K/AKT通路缓解糖尿病肾病中的足细胞损伤DOI: 10.1155/jdr/6568591 BMC endocrine disorders IF: 03.300Volume 25, Issue 1No.82High serum isthmin-1 as a biomarker for the progression of renal function decline in patients with type 2 diabetes mellitus高血清isthmin-1作为2型糖尿病患者肾功能下降进展的生物标志物DOI: 10.1186/s12902-025-02093-x J Clin Biochem Nutr IF: 01.700Volume 77, Issue 3No.83Loganic acid ameliorates diabetic cardiomyopathy via suppressing TLR4/p38 MAPK signaling-mediated oxidative stress and inflammation马钱子酸通过抑制TLR4/p38 MAPK信号介导的氧化应激和炎症改善糖尿病心肌病DOI: 10.3164/jcbn.25-91 Frontiers in nutrition IF: 05.100Volume 12, Issue No.84Atherosclerosis index and BMI: new predictors of cognitive function in ischemic survivors动脉粥样硬化指数与BMI：缺血性中风幸存者认知功能的新预测因子DOI: 10.3389/fnut.2025.1703425 BMC endocrine disorders IF: 03.300Ahead of Print.No.85Metabolically healthy obesity increases the risks of MASLD and hyperuricemia: a cohort study with mediation analysis代谢健康型肥胖增加MASLD和高尿酸血症风险：一项包含中介分析的队列研究DOI: 10.1186/s12902-025-02106-9 其他发布内容（207） More Published Articles Eur J Intern Med IF: 06.100Ahead of Print.No.01Robustness of randomized controlled trial evidence for SGLT2 inhibitors in heart failure with preserved and mildly reduced ejection fractionDOI: 10.1016/j.ejim.2025.106615 Diabetologia IF: 10.200Ahead of Print.No.02Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney diseaseDOI: 10.1007/s00125-025-06612-2 Nature cell biology IF: 19.100Ahead of Print.No.03Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasmaDOI: 10.1038/s41556-025-01795-7 Scientific reports IF: 03.900Volume 15, Issue 1No.04Context matters in machine learning based disease prediction with insights from diverse clinical and symptom dataDOI: 10.1038/s41598-025-26855-8 Nature communications IF: 15.700Ahead of Print.No.05Structure of an LGR dimer, an 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mellitus: a case-control studyDOI: 10.1007/s00784-025-06647-0 Diabetologia IF: 10.200Ahead of Print.No.33Improving medication adherence in type 2 diabetes: strategies for better clinical and economic outcomesDOI: 10.1007/s00125-025-06617-x Pharmacological research IF: 10.500Ahead of Print.No.34History of Glucagon-like Peptide-1 Receptor AgonistsDOI: 10.1016/j.phrs.2025.108045 Georgian Medical NewsVolume 2025, Issue 366No.35A DESCRIPTIVE STUDY ON THE TRENDS OF CAUSATIVE BACTERIA AND ANTIMICROBIAL RESISTANCE PROFILES IN PATIENTS WHO DEVELOPED SEPSIS FOLLOWING GASTRIC SLEEVE RESECTIONhttps://pubmed.ncbi.nlm.nih.gov/41314197 Progress in brain researchVolume 297, Issue No.36Future horizons: Innovation, aging, and equity未来视野：创新、老龄化与公平DOI: 10.1016/bs.pbr.2025.08.010 Obesity surgery IF: 03.100Ahead of Print.No.37Development and External Validation of a Machine Learning-Based Risk Score for Stent Outcomes in Post-Bariatric Leak Management: The "Alexandria-Bari-Stent" Tool开发并外部验证一种基于机器学习的风险评分工具用于减肥手术后泄漏管理中支架结局：'Alexandria-Bari-Stent'工具DOI: 10.1007/s11695-025-08321-6 Diabetologia IF: 10.200Ahead of Print.No.38Ketone supplementation dose-dependently lowers postprandial blood glucose, lipid and ghrelin levels in individuals with type 2 diabetes: a randomised crossover study酮补充剂量依赖性地降低2型糖尿病患者餐后血糖、血脂和胃饥饿素水平：一项随机交叉研究DOI: 10.1007/s00125-025-06614-0 BMJ open IF: 02.300Volume 15, Issue 11No.39Is Cardiovascular Mortality Among People with Epilepsy increasing? A retrospective US population study癫痫患者的心血管死亡率在上升吗？一项回顾性美国人口研究DOI: 10.1136/bmjopen-2024-095195 Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.40Impact of Empagliflozin on Glomerular Hyperfiltration and Albuminuria in Youth with Type 2 Diabetes: Post-Hoc Analysis of DINAMO恩格列净对青少年2型糖尿病患者肾小球高滤过和白蛋白尿的影响：DINAMO研究的事后分析DOI: 10.2215/CJN.0000000889 Eur J Clin Nutr IF: 03.300Ahead of Print.No.41Iron status in women of reproductive age in Switzerland: the role of inflammation and ferritin thresholds for the prevalence of iron deficiency-a cross-sectional study瑞士育龄女性铁状态：炎症作用和铁蛋白阈值对缺铁患病率的影响——一项横断面研究DOI: 10.1038/s41430-025-01685-z International journal of obesity IF: 03.800Ahead of Print.No.42The association between antibiotic use in infancy and overweight during childhood and adolescence: a historical cohort study婴儿期抗生素使用与儿童和青少年超重的关联：一项历史队列研究DOI: 10.1038/s41366-025-01972-6 International journal of obesity IF: 03.800Ahead of Print.No.43Post-intervention sustainability of time-restricted eating versus caloric restriction: a secondary analysis限时进食与热量限制干预后可持续性比较：一项次要分析DOI: 10.1038/s41366-025-01968-2 Scientific reports IF: 03.900Volume 15, Issue 1No.44Examining the interplay between sdLDL, resistin, and BMI探讨sdLDL、抵抗素与BMI之间的相互作用DOI: 10.1038/s41598-025-26772-w Annals of surgical oncology IF: 03.500Ahead of Print.No.45Waist-to-Height Ratio as a Predictor Complementary to BMI for Postoperative Pancreatic Fistula After Pancreatoduodenectomy for Periampullary Tumors腰高比作为BMI的补充预测因子用于壶腹周围肿瘤胰十二指肠切除术后胰腺瘘DOI: 10.1245/s10434-025-18575-0 Microbial ecology IF: 04.000Ahead of Print.No.46Bioactive Plasmid- and Phage-Encoded Antimicrobial Peptides (AMPs) in the Human Gut: A Metatranscriptome-Virome Profiling Reveals Exploratory Links to Metabolic Human Diseases人类肠道中质粒和噬菌体编码的生物活性抗菌肽（AMPs）：宏转录组-病毒组分析揭示与代谢性人类疾病的探索性关联DOI: 10.1007/s00248-025-02620-2 Scand J Psychol IF: 02.100Ahead of Print.No.47Directionality of Self-Regulation and Self-Efficacy Within a Treatment Targeting Cardiovascular Exercise and Emotional Eating in Women: Interpretation and Application of Behavioral Theory女性中心血管运动和情绪化饮食治疗中的自我调节与自我效能方向性：行为理论的解读与应用DOI: 10.1111/sjop.70057 Journal of women's health IF: 01.900Ahead of Print.No.48Prevalence of Clinical Obesity Based on Updated Definitions among Women by Sexual Identity: Results from 2001 to 2016 National Health and Nutrition Examination Survey基于更新定义的女性临床肥胖患病率与性身份的关系：2001年至2016年国家健康与营养检查调查结果DOI: 10.1177/15409996251401467 J Laparoendosc Adv Surg Tech A IF: 01.100Ahead of Print.No.49Evaluating Bariatric Surgery in Patients Aged 60 Years and Older: A Retrospective Multicenter Comparison of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass评估60岁及以上患者减重手术：袖状胃切除术与Roux-en-Y胃旁路术的回顾性多中心比较DOI: 10.1177/10926429251401463 Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Ahead of Print.No.50Continuity of care in obesity clinical care肥胖临床护理的连续性DOI: 10.1016/j.endien.2025.501658 Curr Probl Pediatr Adolesc Health Care IF: 03.700Ahead of Print.No.51The learning curve of a pediatric bariatric surgery program: Lessons learned from the first 100 patients儿科减重手术项目的学习曲线：从100名患者中学习的教训DOI: 10.1016/j.cppeds.2025.101888 BMJ open IF: 02.300Volume 15, Issue 11No.52The Health Survey of São Paulo - ISA-Physical Activity and Environment Longitudinal Study圣保罗健康调查 - ISA-体力活动与环境纵向研究DOI: 10.1136/bmjopen-2025-107842 BMJ open respiratory research IF: 03.400Volume 12, Issue 1No.53Rheumatoid arthritis and risk of non-tuberculous mycobacterial pulmonary disease: a nationwide longitudinal cohort study类风湿关节炎与非结核分枝杆菌肺病风险：一项全国性纵向队列研究DOI: 10.1136/bmjresp-2025-003397 Korean Journal of Radiology IF: 05.300Volume 26, Issue 12No.54Effects of Computed Tomography Technical Parameters on Body-Composition Analysis计算断层扫描技术参数对身体成分分析的影响DOI: 10.3348/kjr.2025.1140 Physiology & behavior IF: 02.500Ahead of Print.No.55Emotional eating and metabolic dysfunction-associated steatotic liver disease (MASLD): a pre-registered study in a clinical population情绪性饮食与代谢功能障碍相关脂肪性肝病 (MASLD)：一项临床人群的预注册研究DOI: 10.1016/j.physbeh.2025.115186 Die Rehabilitation IF: 02.300Ahead of Print.No.56[Potential and challenges of an outpatient rehabilitation programme for children and adolescents with obesity - Interviews with professionals from rehabilitation centres]肥胖儿童和青少年门诊康复计划的潜力与挑战——康复中心专业人员的访谈DOI: 10.1055/a-2724-3558 Journal of nutrition IF: 03.800Ahead of Print.No.57Plant-based diet as a precursor to human gut diversity植物性饮食作为人类肠道多样性的先导DOI: 10.1016/j.tjnut.2025.11.020 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.58Approach to the Patient: Clinical Outcomes and Interim Strategies Following Discontinuation of Incretin Agonists患者管理方法：停用肠促胰岛素激动剂后的临床结局与过渡策略DOI: 10.1210/clinem/dgaf641 Georgian Medical NewsVolume 2025, Issue 366No.59HEALTH-RELATED QUALITY OF LIFE OF POST-COVID-19 PATIENTS IN KAZAKHSTAN哈萨克斯坦COVID-19后遗症患者健康相关生活质量研究https://pubmed.ncbi.nlm.nih.gov/41314198 Clin Neurol Neurosurg IF: 01.600Ahead of Print.No.60Factors associated with venous thromboembolism in hospitalized traumatic brain injury patients with external ventricular drains: Retrospective cohort study住院创伤性脑损伤患者使用外脑室引流时静脉血栓栓塞的相关因素：回顾性队列研究DOI: 10.1016/j.clineuro.2025.109265 Women and birth IF: 04.100Ahead of Print.No.61"Running in circles": Breastfeeding experiences in women who have had bariatric surgery before pregnancy: A qualitative study"原地打转"：怀孕前接受减重手术的女性母乳喂养经历的定性研究DOI: 10.1016/j.wombi.2025.102146 J Nutr Health Aging IF: 04.000Ahead of Print.No.62Associations of Individual Beverage Types and Substitution with Dementia Risk: A UK Biobank Cohort Study个体饮料类型与替代与痴呆风险的关联：一项英国生物样本库队列研究DOI: 10.1016/j.jnha.2025.100740 Drug and alcohol dependence IF: 03.600Ahead of Print.No.63Optimizing measures of drinking to predict alcohol-related consequences优化饮酒测量以预测酒精相关后果DOI: 10.1016/j.drugalcdep.2025.112973 Public health IF: 03.200Ahead of Print.No.64Protective predictors of cardiovascular disease: an explainable AI approach心血管疾病的保护性预测因素：可解释人工智能方法DOI: 10.1016/j.puhe.2025.106050 Georgian Medical NewsVolume 2025, Issue 366No.65THE INCIDENCE OF URINARY TRACT INFECTION AMONG PATIENTS TREATED WITH VARIABLE DOSES OF DAPAGLIFLOZIN: A COMPARATIVE STUDY不同剂量达格列净治疗患者尿路感染发生率比较研究https://pubmed.ncbi.nlm.nih.gov/41314192 Nature communications IF: 15.700Volume 16, Issue 1No.66Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia炎症损害撒哈拉以南非洲和南亚急性疾病住院儿童出院后的生长DOI: 10.1038/s41467-025-66245-2 Scientific reports IF: 03.900Volume 15, Issue 1No.67Insulin resistance in polycystic ovary syndrome phenotypes and the vicious cycle model in its etiology多囊卵巢综合征表型中的胰岛素抵抗及其病因学中的恶性循环模型DOI: 10.1038/s41598-025-26718-2 Nature communications IF: 15.700Volume 16, Issue 1No.68Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries血浆脂多糖水平预测低收入和中等收入国家急病儿童的死亡率DOI: 10.1038/s41467-025-65429-0 Nature immunology IF: 27.600Ahead of Print.No.69A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes微环境驱动的HLA-II相关胰岛素新抗原引发糖尿病中持续性记忆T细胞激活DOI: 10.1038/s41590-025-02343-z Contact dermatitis IF: 04.600Ahead of Print.No.70Results of GC-MS Analyses of 40 Extracts of Diabetes Devices40种糖尿病设备提取物的GC-MS分析结果DOI: 10.1111/cod.70052 Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Ahead of Print.No.71Polymorphisms in TLR4 and IL6 and their association with obesity and insulin resistance in a Venezuelan populationTLR4和IL6基因多态性与委内瑞拉人群肥胖和胰岛素抵抗的关联DOI: 10.1016/j.endien.2025.501657 Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.72Suppressive Effect of Myristic Acid on Postprandial Blood Glucose Elevation in Healthy Adults with High Blood Glucose Levels: A Double-blinded, Randomized, Placebo-controlled, Parallel-group Study肉豆蔻酸对高血糖健康成人餐后血糖升高的抑制作用：一项双盲、随机、安慰剂对照、平行组研究DOI: 10.1016/j.clnesp.2025.11.148 Contemporary clinical trials IF: 01.900Ahead of Print.No.73Effects of daily low oxygen exposure on weight status, body composition, and metabolic health in adults with obesity: Protocol for a randomized, double-blind, controlled-feeding study每日低氧暴露对肥胖成年人体重状态、身体成分和代谢健康的影响：一项随机、双盲、控制喂养研究方案DOI: 10.1016/j.cct.2025.108167 J Nutr Biochem IF: 04.900Ahead of Print.No.74Olive-derived elenolic acid surpasses metformin and rivals liraglutide in managing blood glucose and obesity in mouse models of type 2 diabetes橄榄来源的elenolic acid在管理2型糖尿病小鼠模型中的血糖和肥胖方面超越metformin并媲美利拉鲁肽DOI: 10.1016/j.jnutbio.2025.110206 Neuroscience IF: 02.800Ahead of Print.No.75The interface between the homeostatic and hedonic energy balance circuitries in the regulation of appetitive behavior: A focus on steroidogenic factor-1/pituitary adenylate cyclase-activating polypeptide neurons in the hypothalamic ventromedial nucleus稳态和享乐性能量平衡回路在食欲行为调节中的界面：聚焦于下丘脑腹内侧核中的类固醇生成因子-1/垂体腺苷酸环化酶激活多肽神经元DOI: 10.1016/j.neuroscience.2025.11.038 Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.76Chat, Gemini and Claude at the dinner table: assessing general-purpose AI tools for carbohydrate counting in the context of type 1 diabetes餐桌上的Chat、Gemini和Claude：评估通用AI工具在1型糖尿病碳水化合物计数中的应用DOI: 10.1016/j.diabres.2025.113031 Gynecol Obstet Fertil Senol IF: 00.600Ahead of Print.No.77[Benefits and risks of antenatal corticosteroids]产前皮质类固醇的益处与风险DOI: 10.1016/j.gofs.2025.11.005 Experimental Eye Research IF: 02.700Ahead of Print.No.78Regenerative Effects of Topical Insulin on Corneal Wound Healing: From Surface Restoration to Stromal Remodeling局部胰岛素对角膜伤口愈合的再生效应：从表面修复到基质重塑DOI: 10.1016/j.exer.2025.110775 Journal of controlled release IF: 11.500Ahead of Print.No.79Oral gene delivery platform based on glycol chitosan-PEG-lactoferrin conjugate基于乙二醇壳聚糖-PEG-乳铁蛋白偶联物的口服基因递送平台DOI: 10.1016/j.jconrel.2025.114463 Georgian Medical NewsVolume 2025, Issue 366No.80THE INCIDENCE OF URINARY TRACT INFECTION AMONG PATIENTS TREATED WITH VARIABLE DOSES OF DAPAGLIFLOZIN: A COMPARATIVE STUDY使用变量剂量的达格列净治疗患者中尿路感染的发生率：一项比较研究https://pubmed.ncbi.nlm.nih.gov/41314192 Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.81Experience with insulin detemir for type 2 diabetes in older people and people with comorbidities胰岛素detemir在老年人和合并症患者中治疗2型糖尿病的经验DOI: 10.1016/j.dsx.2025.103327 Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.82Therapeutic prospects of modulating TLR4/MAPK/ROS signalling in obesity-associated neuroinflammation调节TLR4/MAPK/ROS信号在肥胖相关神经炎症中的治疗前景DOI: 10.1016/j.biopha.2025.118805 Experimental Eye Research IF: 02.700Ahead of Print.No.83Small extracellular vesicles derived from human retinal pericytes under high glucose and hypoxia conditions promote endothelial cell dysfunction in vitro高葡萄糖和缺氧条件下人视网膜周细胞来源的小细胞囊泡在体外促进内皮细胞功能障碍DOI: 10.1016/j.exer.2025.110768 J Diabetes Complications IF: 03.100Ahead of Print.No.84Dipeptidyl peptidase-4 inhibitors and diabetic retinopathy in type 2 diabetes: A network meta-analysis of randomized clinical trials二肽基肽酶-4抑制剂与2型糖尿病视网膜病变：一项随机临床试验的网络荟萃分析DOI: 10.1016/j.jdiacomp.2025.109234 International Heart Journal IF: 01.300Volume 66, Issue 6, Page 925-1037No.85Association between Cardiovascular-Kidney-Metabolic Syndrome and Relative Muscle Loss in American Adults心血管-肾脏-代谢综合征与美国成年人相对肌肉损失的关联DOI: 10.1536/ihj.25-117 International Heart Journal IF: 01.300Volume 66, Issue 6, Page 925-1037No.86The Association Between Body Mass Index and In-hospital Mortality in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention体重指数与接受经皮冠状动脉介入治疗的急性心肌梗死患者院内死亡率的关联DOI: 10.1536/ihj.25-135 Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.87Preterm labour induction: modalities, implications and outcomes早产引产：方式、影响与结局DOI: 10.1016/j.ejogrb.2025.114847 J Foot Ankle Res IF: 02.200Volume 18, Issue 4No.88A Cross-Sectional Study Exploring the Suitability of Skin Hydration Measurement Devices for Use on the Foot一项横断面研究探索皮肤水合测量设备在足部使用的适宜性DOI: 10.1002/jfa2.70104 Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.89The EndoCompass Supplement: Preface, Acknowledgments, and DeclarationsEndoCompass 增刊：前言、致谢与声明DOI: 10.1159/000549150 Diabetes Technol Ther IF: 06.300Ahead of Print.No.90Arterialization of Venous Blood May Affect the Time Lag of Continuous Glucose Sensors静脉血动脉化可能影响连续葡萄糖传感器的时间延迟DOI: 10.1177/15209156251403566 J Vet Emerg Crit Care (San Antonio) IF: 01.200Ahead of Print.No.91Iatrogenic Pneumothorax in a Cat Following Placement of a Continuous Glucose Sensor猫放置连续血糖传感器后发生医源性气胸DOI: 10.1111/vec.70065 Journal of Vascular Research IF: 02.300Ahead of Print.No.92Assessing Sex Differences in Metabolic Disease on Vasculopathy Using the Vascular Health Index使用血管健康指数评估代谢疾病对血管病变的性别差异DOI: 10.1159/000549739 Advanced science IF: 14.100Ahead of Print.No.93Label-Free Leukocyte Biophysical Profiling Using Impedance-Deformability Cytometry for Rapid Cardiovascular Risk Stratification基于阻抗-变形性细胞术的无标记白细胞生物物理特征分析用于快速心血管风险分层DOI: 10.1002/advs.202516021 PACE IF: 01.300Ahead of Print.No.94Predictors of Atrial High-Rate Episodes and Inappropriate Device Therapy in Implantable Cardioverter Defibrillators植入式心律转复除颤器中房性高频率事件与不适当设备治疗的预测因子DOI: 10.1111/pace.70094 Physical biology IF: 01.600Ahead of Print.No.95Network modeling and analysis of MAP Kinase pathway to assess role of genes in tumor developmentMAP激酶通路的网络建模与分析以评估基因在肿瘤发展中的作用DOI: 10.1088/1478-3975/ae25af Science advances IF: 12.500Volume 11, Issue 48No.96Metabolic reprogramming in Fanconi anemia: Evidence of compromised glucose oxidation, enhanced ketogenesis, and metabolic inflexibility范可尼贫血中的代谢重编程：葡萄糖氧化受损、酮体生成增强和代谢不灵活性的证据DOI: 10.1126/sciadv.ady6117 Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.97Impact of semaglutide exposure on fetal and neonatal outcomes in pregnant women: a systematic review司美格鲁肽暴露对孕妇胎儿和新生儿结局的影响：一项系统评价DOI: 10.1016/j.ejogrb.2025.114836 Current obesity reports IF: 11.000Volume 14, Issue 1No.98Mood Disorders, Metabolic Bariatric Surgery, and Weight Loss Pharmacotherapy: a Research Update情绪障碍、代谢减重手术和减重药物疗法：研究更新DOI: 10.1007/s13679-025-00674-4 Obesity surgery IF: 03.100Ahead of Print.No.99Prevalence and Predictors of Hepatic Steatosis in Patients Undergoing Sleeve Gastrectomy: A Biopsy-proven Study接受袖状胃切除术患者肝脂肪变性的患病率及预测因素：一项活检证实的研究DOI: 10.1007/s11695-025-08386-3 Pediatric Cardiology IF: 01.400Ahead of Print.No.100Physician Preparedness for Managing Juvenile Obesity in the MENA Region: A Cross-Sectional Analysis of Perceptions, Knowledge, Practices, and Barriers中东和北非地区医生管理青少年肥胖的准备度：一项关于认知、知识、实践和障碍的横断面分析DOI: 10.1007/s00246-025-04121-y Nutrición hospitalaria IF: 01.100Ahead of Print.No.101Comparative impact of vitamin D intake on childhood obesity in Qatar - A retrospective analysis study维生素D摄入对卡塔尔儿童肥胖影响的比较——一项回顾性分析研究DOI: 10.20960/nh.06072 Nutrición hospitalaria IF: 01.100Ahead of Print.No.102Sensitivity of body mass index as a current criterion of nutrition: new body mass index redefinition for young adults身体质量指数作为营养评估标准的敏感性：针对年轻成年人的新BMI定义DOI: 10.20960/nh.05473 J Pediatric Infect Dis Soc IF: 02.600Ahead of Print.No.103Weight Gain Among Children and Adolescents on Dolutegravir in Spain西班牙儿童和青少年使用多替拉韦后的体重增加DOI: 10.1093/jpids/piaf110 Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.104Addressing weight stigma and communicating with patients应对体重污名并改善与患者沟通DOI: 10.20945/2359-4292-2025-0335 L?knablaeie IF: 00.600Volume 111, Issue 12No.105[New recommedations in the treatment of restless legs syndrome - dopaminergic drugs on the way out]不宁腿综合征治疗新推荐——多巴胺能药物退场DOI: 10.17992/lbl.2025.12.868 Probiotics Antimicrob Proteins IF: 04.400Ahead of Print.No.106Gut Microbiome in Obesity: A Narrative Review of Mechanisms, Interventions, and Future Directions肠道微生物组在肥胖中的作用：机制、干预和未来方向的叙述性综述DOI: 10.1007/s12602-025-10855-1 Int J Clin Pharm IF: 03.200Ahead of Print.No.107Pharmacist input to depression screening and management in patients with diabetes: a systematic review药师在糖尿病患者抑郁症筛查和管理中的参与：一项系统评价DOI: 10.1007/s11096-025-02056-1 Advances in therapy IF: 04.000Ahead of Print.No.108Correction to: Epidemiology Landscape and Impact of Overweight and Obesity in Adults: Multi-country Results from the IMPACT-O Study更正：成人超重和肥胖的流行病学格局与影响：来自IMPACT-O研究的多国结果DOI: 10.1007/s12325-025-03446-7 Molecular biology reports IF: 02.800Volume 53, Issue 1No.109Policosanol ameliorates testicular injury and improves steroidogenesis in diabetic hypercholesterolemic ratsPolicosanol 改善糖尿病高胆固醇血症大鼠的睾丸损伤并促进类固醇生成DOI: 10.1007/s11033-025-11241-4 Obesity surgery IF: 03.100Ahead of Print.No.110The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study增加钠摄入对无糖尿病Roux-en-Y胃旁路术后患者碳水化合物丰富餐后葡萄糖稳态的影响：一项概念验证、随机、开放标签、交叉研究DOI: 10.1007/s11695-025-08420-4 Diabetes therapy IF: 02.600Ahead of Print.No.111Correction to: Quantifying Patient Preferences for Basal Insulin Treatments in Adults Living with Type 2 Diabetes: A Discrete Choice Experiment in Canada, Spain, France, and Japan量化成年2型糖尿病患者对基础胰岛素治疗的偏好：在加拿大、西班牙、法国和日本的离散选择实验DOI: 10.1007/s13300-025-01820-w Diabetes therapy IF: 02.600Ahead of Print.No.112Cost-effectiveness of Freestyle Libre Systems for People with Type 2 Diabetes Mellitus on Basal Insulin Therapy in the Netherlands: An Economic Evaluation from a Societal Perspective Within a Publicly Funded Healthcare SystemFreestyle Libre系统在荷兰用于基础胰岛素治疗的2型糖尿病患者的成本效益：基于公共资助医疗体系社会视角的经济评估DOI: 10.1007/s13300-025-01821-9 Histochemistry and cell biology IF: 02.100Volume 163, Issue 1No.113Enhanced skin regeneration in diabetic wounds using collagen-hyaluronic acid scaffold incorporated with epigallocatechin gallate: a multifactorial healing approach胶原-透明质酸支架结合EGCG增强糖尿病伤口皮肤再生的多因素愈合策略DOI: 10.1007/s00418-025-02439-5 Clinical oral investigations IF: 03.100Volume 29, Issue 12No.114Comparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases比较不同系统性疾病中富血小板纤维蛋白生物材料中生长因子的浓度DOI: 10.1007/s00784-025-06673-y Basic Research in Cardiology IF: 08.000Ahead of Print.No.115Serum amyloid A in HFpEF and cardiometabolic diseases血清淀粉样蛋白A在HFpEF和心脏代谢疾病中的作用DOI: 10.1007/s00395-025-01150-9 Nutrición hospitalaria IF: 01.100Ahead of Print.No.116Anxiety in medical students: its relationship with the consumption of unhealthy foods, obesity, and the risk of cardiometabolic diseases医学生焦虑：与不健康食物消费、肥胖及心脏代谢疾病风险的关系DOI: 10.20960/nh.05689 Nutrición hospitalaria IF: 01.100Ahead of Print.No.117Predictive value of novel inflammatory markers for mortality in patients with chronic kidney disease ‒ Evidence from NHANES 1999-2018新型炎症标志物对慢性肾脏病患者死亡率的预测价值——基于NHANES 1999-2018的证据DOI: 10.20960/nh.05709 Expert Rev Clin Pharmacol IF: 03.000Ahead of Print.No.118Clinical pharmacokinetics on canagliflozin: a systematic review of in-vitro and in-vivo studies卡格列净的临床药代动力学：体外和体内研究的系统评价DOI: 10.1080/17512433.2025.2597512 J Magn Reson Imaging IF: 03.500Ahead of Print.No.119Prospective Comparison of DWI-Derived Virtual MR Elastography and Conventional MR Elastography in Metabolic Dysfunction-Associated Steatotic Liver Disease and Healthy Volunteers在代谢功能障碍相关脂肪性肝病和健康志愿者中DWI衍生的虚拟MR弹性成像与常规MR弹性成像的前瞻性比较DOI: 10.1002/jmri.70192 Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.120Autonomic neuropathy in diabetes糖尿病自主神经病变DOI: 10.20945/2359-4292-2025-0406 Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.121Hypercoagulability in Cushing's syndrome: past, present, future库欣综合征中的高凝状态：过去、现在、未来DOI: 10.20945/2359-4292-2025-0095 Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.122Clinical dermatoendocrinology: saving lives by looking at the skin临床皮肤内分泌学：通过观察皮肤挽救生命DOI: 10.20945/2359-4292-2025-0062 JMIR diabetes IF: 02.600Volume 10, Issue No.123Toward a Personalized Basal Tuner for Detecting Basal Rate Inaccuracies in Type 1 Diabetes Mellitus Without Meal Data: Algorithm Development and Retrospective Validation Study迈向无需餐食数据的1型糖尿病基础率不准确性检测的个性化基础率调谐器：算法开发与回顾性验证研究DOI: 10.2196/72769 J Am Geriatr Soc IF: 04.500Ahead of Print.No.124Predictors of a Gabapentinoid-Loop-Diuretic Prescribing Cascade in U.S. Nursing Home Residents美国养老院居民中加巴喷丁-袢利尿剂处方级联的预测因素DOI: 10.1111/jgs.70219 JMIR formative research IF: 02.100Volume 9, Issue No.125Developing eHealth Interventions to Improve Diabetes Management in Emerging Adulthood: Qualitative Formative Study开发电子健康干预措施以改善新兴成年期糖尿病管理：定性形成性研究DOI: 10.2196/75623 Transfusion IF: 02.000Ahead of Print.No.126Hemoglobin A1c levels do not affect vasovagal risk in blood donors血红蛋白A1c水平不影响献血者血管迷走性反应风险DOI: 10.1111/trf.70012 Medicina IF: 00.600Volume 85, Issue 6No.127[Mild autonomic cortisol secretion: comorbidities and surgical treatment outcomes]轻度自主性皮质醇分泌：合并症与手术治疗结局https://pubmed.ncbi.nlm.nih.gov/41313106 ANZ journal of surgery IF: 01.600Ahead of Print.No.128Melioidosis Aortic Aneurysms, 2019-2025: Incidence, Management and Outcomes From a Regional Tertiary Centre in North Queensland类鼻疽主动脉瘤，2019-2025：来自北昆士兰地区三级中心的发病率、管理和结局DOI: 10.1111/ans.70400 Acta médica portuguesa IF: 01.000Ahead of Print.No.129Immune Checkpoint Inhibitor-Induced Thyroidal, Pancreatic, and Pituitary Dysfunction: Diagnostic Challenges in a Cancer Patient免疫检查点抑制剂诱导的甲状腺、胰腺和垂体功能障碍：癌症患者的诊断挑战DOI: 10.20344/amp.23752 Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.130Cardio-kidney-metabolic (CKM) framework: A nephrologist's perspective心肾代谢（CKM）框架：肾脏病学家的视角DOI: 10.20945/2359-4292-2025-0405 Arch Endocrinol Metab IF: 02.300Volume 70, Issue special 1No.131Subclinical primary aldosteronism亚临床原发性醛固酮增多症DOI: 10.20945/2359-4292-2025-0400 Archiv der Pharmazie IF: 03.600Volume 358, Issue 11No.132Synthesis of Promising Biguanide Derivatives Bearing Urea/Thiourea as Type II Antidiabetic Agents合成含有尿素/硫脲的潜力双胍衍生物作为II型抗糖尿病药物DOI: 10.1002/ardp.70150 Mol Nutr Food Res IF: 04.200Ahead of Print.No.133Synbiotic Nutraceutical Mitigates Gestational Diabetes Effects and Cardiovascular Dysfunction in Rat Offspring合生元营养补充剂减轻大鼠后代的妊娠期糖尿病效应和心血管功能障碍DOI: 10.1002/mnfr.70340 Obesity surgery IF: 03.100Ahead of Print.No.134Effects of Semaglutide and Tirzepatide on Recurrent Weight Gain After Bariatric Surgery: A Systematic Review and Meta-analysis司美格鲁肽和替尔泊肽对减重手术后复发性体重增加的影响：一项系统综述和荟萃分析DOI: 10.1007/s11695-025-08414-2 Nephrol Dial Transplant IF: 05.600Ahead of Print.No.135A Consensus Statement on the management of Vertebral Fractures in CKD stages G4-G5D关于CKD G4-G5D期椎体骨折管理的共识声明DOI: 10.1093/ndt/gfaf256 Physiological reports IF: 01.900Volume 13, Issue 23No.136The effect of a ketone monoester drink on blood glucose and substrate oxidation in adults with metabolic syndrome and matched controls酮酯单酯饮料对代谢综合征成人和匹配对照组血糖及底物氧化的影响DOI: 10.14814/phy2.70676 Journal of medical case reports IF: 00.900Volume 19, Issue 1No.137Carbuncle management: skin-sparing saucerization followed by delayed primary closure is a new treatment modality: a case series痈管理：保留皮肤的碟形切除术后延迟一期闭合是一种新的治疗方式：一个病例系列DOI: 10.1186/s13256-025-05309-9 BMC ophthalmology IF: 01.700Ahead of Print.No.138Prevalence of retinopathy of prematurity in African preterm infants and evaluation of the accuracy of the WINROP predictive algorithm: an observational clinical study非洲早产儿早产儿视网膜病变的患病率及WINROP预测算法准确性的评估：一项观察性临床研究DOI: 10.1186/s12886-025-04527-5 Ophthalmology science IF: 04.600Volume 6, Issue 1No.139Macrophage-Like Cell Density and Distribution in Relation to Vascular Leakage in Diabetes巨噬细胞样细胞密度和分布与糖尿病血管渗漏的关系DOI: 10.1016/j.xops.2025.100955 Journal of hematology & oncology IF: 40.400Volume 18, Issue 1No.140The gynecologic tumor risk related to GLP-1 receptor agonists and SGLT2 inhibitors use: a network meta-analysis of 91 randomized controlled trialsGLP-1受体激动剂和SGLT2抑制剂使用与妇科肿瘤风险：一项基于91项随机对照试验的网络荟萃分析DOI: 10.1186/s13045-025-01750-x Journal of diabetes IF: 03.700Volume 17, Issue 12No.141Advancing Diabetic Foot Ulcer Care: Focus on the Post-Healing Transition Phase推进糖尿病足溃疡护理：关注愈合后过渡阶段DOI: 10.1111/1753-0407.70173 Canadian liver journal IF: 01.200Volume 8, Issue 3No.142Evaluation of a novel albumin platelet product (APP) fibrosis index and three non-invasive fibrosis indices in metabolic dysfunction-associated steatotic liver disease评估新型白蛋白血小板产物（APP）纤维化指数和三种无创纤维化指数在代谢功能障碍相关脂肪性肝病中的表现DOI: 10.3138/canlivj-2025-0017 SAGE open medicine IF: 02.100Volume 13, Issue No.143Corrigendum to "Glycemic management in patients with immune-related diabetes mellitus: A scoping review"勘误：'免疫相关糖尿病患者的血糖管理：范围综述'DOI: 10.1177/20503121251378700 Plast Reconstr Surg Glob Open IF: 01.800Volume 13, Issue 11No.144A Retrospective Application of Deep Sternal Wound Dehiscence and Malunion Risk Scores on Sternal Nonunion Patients胸骨不愈合患者中胸骨深部伤口裂开和错位风险评分的回顾性应用DOI: 10.1097/GOX.0000000000007281 Transplant international IF: 03.000Volume 38, Issue No.145The Variation in Practice of the Living Donor Kidney Transplant Pathway in the UK: Results of a National Survey英国活体供肾移植路径实践的变化：全国调查结果DOI: 10.3389/ti.2025.15341 Geriatr Orthop Surg Rehabil IF: 01.600Volume 16, Issue No.146Evaluating Barriers to Achieving the Minimal Important Change in Older Patients With Hip Fractures After Post-Acute Care评估老年髋部骨折患者在急性期后护理后达到最小重要变化的障碍DOI: 10.1177/21514593251403425 J Clin Transl Endocrinol IF: 03.300Volume 42, Issue No.147Alternative approaches to glucose measurements during oral glucose tolerance testing in youth with cystic fibrosis: a mixed methods pilot study囊性纤维化青少年口服葡萄糖耐量试验中葡萄糖测量的替代方法：一项混合方法试点研究DOI: 10.1016/j.jcte.2025.100421 Curēus IF: 01.300Volume 17, Issue 11No.148Post-COVID-19 Barriers to Diabetic Retinopathy Screening Attendance: An Updated Systematic Review后COVID-19时代糖尿病视网膜病变筛查出勤的障碍：一项更新的系统性回顾DOI: 10.7759/cureus.96550 Frontiers in pharmacology IF: 04.800Volume 16, Issue No.149A comprehensive review on diabetic foot ulcer addressing vascular insufficiency, impaired immune response, and delayed wound healing mechanisms糖尿病足溃疡的综合综述：探讨血管功能不全、免疫反应受损和伤口愈合延迟机制DOI: 10.3389/fphar.2025.1622055 Frontiers in pharmacology IF: 04.800Volume 16, Issue No.150Diabetes and traditional remedies in Medieval Persia: a historical perspective中世纪波斯的糖尿病与传统疗法：历史视角DOI: 10.3389/fphar.2025.1673440 Curēus IF: 01.300Volume 17, Issue 10No.151Ten-Year Follow-Up of Visual Outcomes After Vitrectomy for Clinically Non-Tractional Diabetic Macular Edema玻璃体切除术用于临床非牵拉性糖尿病黄斑水肿后视力结果的十年随访DOI: 10.7759/cureus.95537 Curēus IF: 01.300Volume 17, Issue 10No.152A Hypercalcemic Deception: Uncovering an Unusual Case of Familial Hypocalciuric Hypercalcemia高钙血症的欺骗：揭示一个不寻常的家族性低尿钙高钙血症病例DOI: 10.7759/cureus.95514 Curēus IF: 01.300Volume 17, Issue 10No.153Improving Diabetic Foot Care Through a Multidisciplinary Clinic: Experience From Pilgrim Hospital, UK通过多学科诊所改善糖尿病足部护理：来自英国Pilgrim医院的经验DOI: 10.7759/cureus.95480 Orthop J Sports Med IF: 02.500Volume 13, Issue 11No.154Factors Affecting Late-Period Retear That Occurs More than 2 Years After Rotator Cuff Repair影响肩袖修复后2年以上晚期再撕裂的因素DOI: 10.1177/23259671251389121 Am J Ophthalmol Case RepVolume 40, Issue No.155Efficacy of faricimab for recalcitrant multifactorial cystoid macular edemaFaricimab对难治性多因素性囊样黄斑水肿的有效性DOI: 10.1016/j.ajoc.2025.102475 Iran J Nurs Midwifery Res IF: 01.200Volume 30, Issue 6No.156Assessment of Public School Teachers' Knowledge of Type 1 Diabetes among Adolescent Students in Saudi Arabia: A Cross-sectional Study沙特阿拉伯公立学校教师对青少年学生1型糖尿病知识的评估：一项横断面研究DOI: 10.4103/ijnmr.ijnmr_144_24 Diabetology international IF: 01.200Volume 17, Issue 1No.157Time trends in the prescription of sodium-glucose co-transporter-2 inhibitors based on a claims database in Japan from 2014 to 2022: expanded use in older adults, those with comorbidities, and those potentially initiating diabetes treatment基于日本索赔数据库的钠-葡萄糖协同转运蛋白-2抑制剂处方时间趋势（2014-2022）：在老年患者、合并症患者及可能启动糖尿病治疗患者中的扩展使用DOI: 10.1007/s13340-025-00857-3 Diabetology international IF: 01.200Volume 17, Issue 1No.158The association between diabetes knowledge, treatment satisfaction and medication adherence among Malaysian geriatric patients马来西亚老年患者糖尿病知识、治疗满意度与用药依从性之间的关联DOI: 10.1007/s13340-025-00860-8 Diabetology international IF: 01.200Volume 17, Issue 1No.159Effects of a home-based low-to-moderate-intensity dance exercise program on glycemic control and quality of life in elderly patients with type 2 diabetes: a single-arm, intervention study家庭为基础的低至中等强度舞蹈锻炼计划对老年2型糖尿病患者血糖控制和生活质量的影响：一项单臂干预研究DOI: 10.1007/s13340-025-00854-6 Diabetology international IF: 01.200Volume 17, Issue 1No.160Harnessing ROCK biology to revolutionize diabetic nephropathy: decoding mechanisms, designing therapies驾驭ROCK生物学以革新糖尿病肾病：解码机制，设计疗法DOI: 10.1007/s13340-025-00861-7 Oxford medical case reports IF: 00.400Volume 2025, Issue 11No.161The spiked helmet sign in severe sepsis: an unusual electrocardiographic finding in a critically ill patient严重脓毒症中的尖顶头盔征：危重患者中不寻常的心电图发现DOI: 10.1093/omcr/omaf232 Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.162Comparing perinatal outcomes in gestational and cystic-fibrosis related diabetes比较妊娠期糖尿病与囊性纤维化相关糖尿病的围产期结局DOI: 10.1002/ijgo.70615 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.163A narrative review of meal management with the MiniMed™ 780G system: Evolution of dietary management in type 1 diabetesMiniMed™ 780G系统膳食管理叙述性综述：1型糖尿病膳食管理的演进DOI: 10.1111/dom.70310 Diabetes Technol Ther IF: 06.300Ahead of Print.No.164Real-World HbA1c Following Initiation of the Omnipod 5 Automated Insulin Delivery System现实世界中启动Omnipod 5自动胰岛素输送系统后的HbA1c变化DOI: 10.1177/15209156251395014 HGG Adv IF: 03.600Ahead of Print.No.165S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsS4-Multi：在祖先多样化人群中增强多基因评分预测DOI: 10.1016/j.xhgg.2025.100551 Eur J Med Res IF: 03.400Ahead of Print.No.166Cerebrospinal fluid visinin-like protein, glial cell line-derived neurotrophic factor, and cadherin-6 alterations in pregnancy complications妊娠并发症中脑脊液视锥蛋白样蛋白、胶质细胞源性神经营养因子和钙黏蛋白-6的改变DOI: 10.1186/s40001-025-03584-2 JCTS IF: 01.500Ahead of Print.No.167Hybrid prosthesis in frozen elephant trunk procedures for hereditary thoracic aortic diseases: a 14-year single-aortic center experience混合假体在遗传性胸主动脉疾病冰冻象鼻技术中的应用：一项14年单中心经验DOI: 10.1186/s13019-025-03738-7 BMC biology IF: 04.500Volume 23, Issue 1No.168Trajectory of genome editing technology基因组编辑技术的轨迹DOI: 10.1186/s12915-025-02450-1 Reproductive health IF: 03.400Ahead of Print.No.169Factors associated with stillbirth in four selected hospital maternity units: an unmatched case-control study in Eswatini在斯威士兰四个选定医院产科单位中与死胎相关的因素：一项不匹配的病例对照研究DOI: 10.1186/s12978-025-02215-7 BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.170Real-world use of non-pregnancy-specific automated insulin delivery systems during gestation and delivery: a case series非妊娠特异性自动胰岛素输送系统在妊娠和分娩期间的现实世界使用：一个案例系列DOI: 10.1186/s12884-025-08420-3 BMC public health IF: 03.600Volume 25, Issue 1No.171A population-based survey of self-reported and IIEF-defined erectile dysfunction among adult men in the United States in 20212021年美国成年男性中自我报告和IIEF定义的勃起功能障碍人群调查DOI: 10.1186/s12889-025-24808-4 BMC geriatrics IF: 03.800Volume 25, Issue 1No.172Factors associated with psychological well-being among older adults attending daycare centers of Kathmandu, Nepal: a cross-sectional path-analytical study尼泊尔加德满都日托中心老年人心理健康相关因素：一项横断面路径分析研究DOI: 10.1186/s12877-025-06506-3 Journal of cosmetic dermatology IF: 02.500Volume 24, Issue 12No.173Increased Prevalence of Insulin Resistance and Metabolic Syndrome in Men With Early-Onset Androgenetic Alopecia: A Case-Control Study男性早期雄激素性脱发中胰岛素抵抗和代谢综合征患病率增加：一项病例对照研究DOI: 10.1111/jocd.70458 Current opinion in pediatrics IF: 02.500Ahead of Print.No.174The role of sex steroids in the human gut microbiome性类固醇在人类肠道微生物组中的作用DOI: 10.1097/MOP.0000000000001527 JID innovationsVolume 6, Issue 1No.175Lower Neighborhood Socioeconomic Status Is Associated with Moderate-Severe Hidradenitis Suppurativa: A Cross-Sectional Study较低邻里社会经济地位与中重度化脓性汗腺炎相关：一项横断面研究DOI: 10.1016/j.xjidi.2025.100423 JHLT openVolume 11, Issue No.176Impact of severe obesity on heart transplantation outcomes: A meta-analysis of survival and complications严重肥胖对心脏移植结局的影响：生存与并发症的荟萃分析DOI: 10.1016/j.jhlto.2025.100404 Comput Struct Biotechnol J IF: 04.100Volume 27, Issue No.177Multi-matrix metabolomics in rare monogenic diabetes syndromes: Analysis of oral fluids and serum in carriers of pathogenic variants in the ALMS1/BBS genes罕见单基因糖尿病综合征中的多基质代谢组学：ALMS1/BBS基因致病性变异携带者的口腔液和血清分析DOI: 10.1016/j.csbj.2025.10.040 J Diabetes Metab Disord IF: 01.600Volume 24, Issue 2No.178The association of metabolic syndrome and its components with brain volumes and structural connections: a systematic review and meta-analysis of observational studies代谢综合征及其组分与脑容量和结构连接的关联：观察性研究的系统综述和荟萃分析DOI: 10.1007/s40200-025-01800-8 F1000ResearchVolume 13, Issue No.179RNA-sequencing Reveals Altered Gene Expression in the Ventromedial Hypothalamus Following Predator Odor ExposureRNA测序揭示捕食者气味暴露后腹内侧下丘脑基因表达改变DOI: 10.12688/f1000research.152034.2 CHEST pulmonaryVolume 3, Issue 3No.180Impact of Effect Modification of Type 2 Inflammation and Sex on Asthma Exacerbation Rates类型2炎症和性别对哮喘加重率的影响修饰作用DOI: 10.1016/j.chpulm.2024.100123 Frontiers in nutrition IF: 05.100Volume 12, Issue No.181Vitamin D deficiency and subsequent risk of obstructive sleep apnea: a multi-institutional retrospective study维生素D缺乏与后续阻塞性睡眠呼吸暂停风险：一项多机构回顾性研究DOI: 10.3389/fnut.2025.1651712 Res Pract Thromb Haemost IF: 03.400Volume 9, Issue 7No.182Venous thromboembolism in obese hormonal contraceptive users: a large national database study肥胖激素避孕药使用者中的静脉血栓栓塞：一项大型国家数据库研究DOI: 10.1016/j.rpth.2025.103230 Curr Opin Endocrinol Diabetes Obes IF: 02.700Ahead of Print.No.183Obesity and infertility: a double whammy肥胖与不孕：双重打击DOI: 10.1097/MED.0000000000000944 Arthritis & rheumatology IF: 10.900Ahead of Print.No.184Dosing Biologic Drugs for Patients with Obesity: One Size Does NOT Fit All肥胖患者生物制剂剂量：一种尺寸不适合所有人DOI: 10.1002/art.43443 Orphanet J Rare Dis IF: 03.500Volume 20, Issue 1No.185The benefit of diet on paradoxical breathing and sleep in Osteogenesis imperfecta饮食对Osteogenesis imperfecta中矛盾呼吸和睡眠的益处DOI: 10.1186/s13023-025-04146-9 Health Res Policy Syst IF: 03.200Volume 23, Issue 1No.186Informing equitable noncommunicable disease prevention policies through lived experience: a scoping review of research approaches通过生活经验告知公平的非传染性疾病预防政策：研究方法的范围综述DOI: 10.1186/s12961-025-01348-2 Chinese medicine IF: 05.700Volume 20, Issue 1No.187Prevalence of traditional Chinese medicine body constitutions in a large community-based study in Hangzhou, China中国杭州大型社区研究中传统中医体质的流行情况DOI: 10.1186/s13020-025-01268-x BMC public health IF: 03.600Ahead of Print.No.188Census-tract broadband connectivity and the risk of diabetes, hypertension and obesity/overweight in California加州人口普查区宽带连接与糖尿病、高血压和肥胖/超重风险DOI: 10.1186/s12889-025-25663-z BMC public health IF: 03.600Volume 25, Issue 1No.189Assessing the impact of community health education programs on preventing non-communicable diseases in rural areas评估社区健康教育项目在农村地区预防非传染性疾病的影响DOI: 10.1186/s12889-025-22620-8 Belitung Nursing Journal IF: 01.400Volume 11, Issue 6No.190The effectiveness of self-efficacy enhancement for foot care program on HbA1c and foot status in people with type 2 diabetes in Thailand: A quasi-experimental study自我效能增强足部护理程序对泰国2型糖尿病患者HbA1c和足部状况的有效性：一项准实验研究DOI: 10.33546/bnj.4131 Belitung Nursing Journal IF: 01.400Volume 11, Issue 6No.191Quality of life and its associated factors among patients with type 2 diabetes mellitus in East Bolaang Mongondow, Indonesia: A cross-sectional study印度尼西亚东波朗蒙贡多地区2型糖尿病患者生命质量及其相关因素：一项横断面研究DOI: 10.33546/bnj.3942 J Clin Biochem Nutr IF: 01.700Volume 77, Issue 3No.192Effect of chronic kidney disease and type 2 diabetes on plasma branched-chain amino acid cross-correlation: a novel metric for evaluating homeostasis慢性肾脏病和2型糖尿病对血浆支链氨基酸交叉相关性的影响：评估稳态的新指标DOI: 10.3164/jcbn.25-47 Curēus IF: 01.300Volume 17, Issue 10No.193Different Barriers, Different Needs: A Qualitative Study on How Educational Level Shapes Barriers to Type 2 Diabetes Self-Management in Urban Pakistan障碍各异，需求不同：教育水平如何影响巴基斯坦城市2型糖尿病自我管理障碍的定性研究DOI: 10.7759/cureus.95477 The aging male IF: 02.600Volume 28, Issue 1No.194Risk-dependent decision-making for circumcision in penile corporoplasty: type-2 diabetes mellitus associated with post-surgical phimosis阴茎体成形术中包皮环切术的风险依赖性决策：2型糖尿病与术后包茎相关DOI: 10.1080/13685538.2025.2591471 Acta Cardiologica Sinica IF: 01.800Volume 41, Issue 6No.195Impact of Obesity Phenotypes on Efficacy and Safety of Catheter Ablation for Patients with Paroxysmal Atrial Fibrillation肥胖表型对阵发性房颤患者导管消融有效性和安全性的影响DOI: 10.6515/ACS.202511_41(6).20250616E Curēus IF: 01.300Volume 17, Issue 10No.196The GOLD-PCP Study: Clinician Insights on Person-Centric Packaging Design of a Triple Fixed-Dose Combination in Type 2 Diabetes CareGOLD-PCP研究：临床医生对2型糖尿病护理中三联固定剂量复方制剂的人性化包装设计的见解DOI: 10.7759/cureus.95473 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.197SGLT2 inhibitor or metformin as standard treatment in early-stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register-based randomised trial on prevention of diabetic complicationsSGLT2抑制剂或metformin作为早期2型糖尿病的标准治疗？SMARTEST研究基线数据：一项新颖的去中心化、基于登记的随机试验，预防糖尿病并发症DOI: 10.1111/dom.70320 Eur J Med Res IF: 03.400Ahead of Print.No.198Development of a novel flow cytometry multiplex immunoassay for the diagnosis of celiac disease simultaneously with autoimmune diabetes开发一种基于流式细胞术的多重免疫分析新方法用于同时诊断乳糜泻和自身免疫性糖尿病DOI: 10.1186/s40001-025-03457-8 Ugeskrift for l?gerVolume 187, Issue 47No.199[Chronic obstructive sleep apnoea]慢性阻塞性睡眠呼吸暂停DOI: 10.61409/V04250291 J Hum Nutr Diet IF: 02.500Volume 38, Issue 6No.200Food Insecurity Is Highly Prevalent Amongst Patients With Chronic Liver Disease in Northern England: A Cross-Sectional Analysis食物不安全在英格兰北部慢性肝病患者中高度普遍：一项横断面分析DOI: 10.1111/jhn.70173 Danish medical journal IF: 01.200Volume 72, Issue 12No.201Implications of a new guideline on treating gestational diabetes in Denmark丹麦妊娠期糖尿病新治疗指南的影响DOI: 10.61409/A04250331 Diabetology & metabolic syndrome IF: 03.900Volume 17, Issue 1No.202Low estimated glucose disposal rate predicts high residual syntax score in non-diabetic ST-elevation myocardial infarction patients低估计葡萄糖利用率预测非糖尿病ST段抬高型心肌梗死患者的高残余SYNTAX评分DOI: 10.1186/s13098-025-01865-8 JCEM case reportsVolume 3, Issue 12No.203Efficacy of Semaglutide in Pediatric Patients With Bardet-Biedl Syndrome and Alström Syndrome司美格鲁肽在Bardet-Biedl综合征和Alström综合征儿科患者中的有效性DOI: 10.1210/jcemcr/luaf266 Diabetology international IF: 01.200Volume 17, Issue 1No.204Glucagon suppression under GLP-1RA therapy: hidden trade-offs for muscle and resilienceGLP-1RA疗法中胰高血糖素抑制：肌肉与代谢恢复力的隐性权衡DOI: 10.1007/s13340-025-00856-4 Transplant international IF: 03.000Volume 38, Issue No.205Impact of Islet Transplantation on Type 1 Diabetes-Related Complication: A Systematic Review胰岛移植对1型糖尿病相关并发症影响的系统评价DOI: 10.3389/ti.2025.15091 Endocr OncolVolume 5, Issue 1No.206Variable GLP-1 receptor expression across diverse neuroendocrine neoplasms: implications for incretin therapies不同神经内分泌肿瘤中GLP-1受体的可变表达：对incretin疗法的影响DOI: 10.1530/EO-25-0051 Stem cell research & therapy IF: 07.300Volume 16, Issue 1No.207Evaluation of safety and efficacy: a case series of chronic limb-threatening ischemia treated with endovascular revascularization and umbilical cord mesenchymal stem cell therapy评估安全性和有效性：一例系列慢性肢体威胁性缺血经血管内血运重建和脐带间充质干细胞治疗的病例系列DOI: 10.1186/s13287-025-04697-5 195 Diabetes Mellitus(DM) 糖尿病 97 Obesity 肥胖症 61 Insulin 胰岛素 26 Type 2 diabetes mellitus(T2DM) 2型糖尿病 10 Metabolic Syndrome 代谢综合征 9 Diabetic Foot 糖尿病足 8 Diabetic Retinopathy 糖尿病视网膜病 7 Metformin 二甲双胍 6 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 5 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 4 Type 1 diabetes mellitus(T1DM) 1型糖尿病 4 Hypoglycemic Agents 降糖药 4 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 4 Semaglutide 司美格鲁肽 4 Dapagliflozin 达格列净 4 Diabetes Complications 糖尿病并发症 3 Empagliflozin 恩格列净 3 Gabapentin 加巴喷丁 3 Tirzepatide 替尔泊肽 2 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 2 Canagliflozin 卡格列净 2 Diabetic Neuropathies 糖尿病性神经病变 1 Diabetic acidosis 糖尿病性酸中毒 1 Diabetic Cardiomyopathies 糖尿病心肌病 1 Pregabalin 普瑞巴林 1 Liraglutide 利拉鲁肽 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Teneligliptin 替格列汀 1 Sitagliptin 西他列汀 1 Saxagliptin 沙格列汀 1 Linagliptin 利格列汀 1 Alogliptin 阿格列汀 编辑：牛祥 审校：牛祥