预约演示
更新于：2025-08-01
Torsemide
托拉塞米
更新于：2025-08-01
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1993-08-23), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H20N4O3S |
InChIKeyNGBFQHCMQULJNZ-UHFFFAOYSA-N |
CAS号56211-40-6 |
关联
61
项与 托拉塞米 相关的临床试验NCT07015671
Bioavailability and Bioequivalence (BA/BE) Study of Extended Release (ER) Torsemide and Spironolactone Fixed Dose Combination (FDC) Tablet in Healthy Subjects
NCT07046975
Bioavailability and Bioequivalence (BA/BE) Study of Extended Release (ER) Torsemide and Spironolactone Fixed Dose Combination (FDC) Tablet in Healthy Adult Human Subjects
NCT07043634
An Open Label, Randomized, Two-period, Two-sequence, Balanced, Single Dose Crossover Study to Evaluate the Effect of Food on the Bioavailability of Extended Release (ER) Torsemide and Spironolactone Fixed Dose Combination (FDC) Tablet in Healthy Adult Human Subjects
100 项与 托拉塞米 相关的临床结果
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100 项与 托拉塞米 相关的转化医学
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100 项与 托拉塞米 相关的专利（医药）
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1,410
项与 托拉塞米 相关的文献（医药）2025-06-01JOURNAL OF HYDROLOGY
A closed municipal landfill as a source of emerging contaminants in adjacent groundwater: pharmaceuticals and personal care products occurrence and environmental risk assessment
作者: Slosarczyk, Kinga ; Dabrowska, Dominika
The aim of this study was to determine the occurrence and perform the environmental risk assessment (ERA) for emerging contaminants, primarily pharmaceuticals and personal care products (PPCPs), in the groundwater near a closed municipal landfill, on the example of a site in Tychy (southern Poland).Groundwater from a shallow aquifer was sampled in two seasons from eight piezometers located upstream, downstream, and on top of the landfill.The anal. covered 128 PPCPs.Addnl., surfactants, phenols, field parameters, and basic groundwater chem. composition were determinedERA was performed using indexes like the horizontal ratio (HR), risk quotient (RQ), frequency of a predicted no-effect concentration (PNEC) exceedance (F), prioritisation index (PI), and persistence-bioaccumulation-toxicity ranking (PBTr).The number of detected PPCPs in the groundwater reached up to 54, with total PPCP concentrations ranging from 492 to 3,230,036 ng/L.The study also revealed the presence of phenols (up to 62 mg/L) and surface active agents, particularly anionic surfactants (up to 77.7 mg/L).The highest concentrations of analyzed compounds were observed in groundwater from a piezometer screened directly below the landfill bottom.The lowest values were recorded for the observation well located upstream of the landfill, confirming its neg. impact and the release of PPCPs into the aquifer.The influence of the landfill was also reflected by low HR values (below 1) and high values of the site-specific risk quotient (above 1).Based on PI results, ibuprofen, bisphenol A, propyphenazone, and sulfamerazine were considered the compounds of highest risk.The same substances were among compounds with the highest PBTr values.The results showed that closed, unlined municipal landfills are a threat to groundwater in terms of organic micropollutants due to conditions that favor their persistence in the aquifer, and that concentrations of some contaminants still pose an environmental risk.
2025-05-30CARDIOLOGY
Torsemide in HFrEF: Revisiting the Role of a Potent Loop Diuretic for Enhanced Outcomes and Renal Safety.
Article
作者: Lee, Wei-Chieh ; Wu, Wen-Shiann
2025-05-01NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
The 10 top prescribed medicines in Germany from 1985 to 2022: pharmacological analysis
Article
作者: Seifert, Roland ; Schröder, Lennart
Abstract:
For many years, pharmaceutical expenditure has been the second largest cost item for statutory health insurance funds (SHI) in Germany after hospital costs. Since prescriptions and expenditure on medicines play such a major role in the German healthcare system, the question arises as to what causes changes in prescriptions. To answer this question, the prescribing trends for the top 10 drugs in 2022 were analyzed over a period of 38 years, from 1985 to 2022. The prescribed defined daily doses (DDD) and the costs per defined daily dose for the 10 medicines were taken from the Arzneiverordnungsreport (AVR) from 1986 to 2023, and the changes in prescribing behavior and their causes were analyzed. The ten most important medicines in 2022, accounting for over 41% of all prescribed daily doses, were ramipril, candesartan, pantoprazole, amlodipine, atorvastatin, levothyroxine, torasemide, simvastatin, bisoprolol, and metoprolol. There are many different reasons for an increase in prescriptions, such as the introduction of generics, a positive study, or a price reduction. Further reasons for an increase in prescriptions are an extension of the indication or the recall of a competing medicine. A change in guidelines or the increasing treatment of laboratory values without clinical symptoms can also lead to an increase in prescriptions. There are also many different reasons for a drop in prescriptions, such as the generic launch of a competitor medicine or a positive study for a competitor medicine. Other reasons for a drop in prescriptions are a negative study or a discussion about the use of a drug. Sometimes, the reasons for prescription changes are also irrational. Overall, this is the most comprehensive long-term analysis of drug prescriptions in Germany. Our data is helpful for predicting drug prescriptions and for preventing future drug shortages not only in Germany but also worldwide.
100 项与 托拉塞米 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 中国 | 2003-12-12 | |
| 心源性水肿 | 日本 | 1999-03-12 | |
| 高血压 | 美国 | 1997-09-09 | |
| 高血压 | 美国 | 1997-09-09 | |
| 水肿 | 美国 | 1993-08-23 | |
| 水肿 | 美国 | 1993-08-23 | |
| 水肿 | 美国 | 1993-08-23 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性充血性心力衰竭 | 临床2期 | 美国 | 2024-06-15 | |
| 膀胱过度活动症 | 临床2期 | 美国 | 2024-06-15 | |
| 尿失禁 | 临床2期 | 美国 | 2024-06-15 | |
| 慢性肾病 | 临床1期 | 印度 | 2017-06-19 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 47 | (Furosemide) | 築衊網膚築鹽壓窪願獵 = 鹹壓窪餘構襯衊範簾鹹 壓夢顧窪壓遞選齋夢構 (鹹觸獵鬱衊醖繭襯壓蓋, 簾願糧鹽糧製襯廠遞淵 ~ 艱鬱網壓淵顧獵範簾襯) 更多 | - | 2024-10-15 | ||
(Torsemide) | 築衊網膚築鹽壓窪願獵 = 積艱鹹襯觸齋淵鏇顧製 壓夢顧窪壓遞選齋夢構 (鹹觸獵鬱衊醖繭襯壓蓋, 壓醖窪觸襯糧鹽餘範壓 ~ 製膚簾構積簾憲觸顧蓋) 更多 | ||||||
临床3期 | 88 | 鹹顧鬱膚獵製網廠憲選(憲壓鏇淵壓餘簾艱憲遞) = 選窪衊夢廠選蓋壓鏇蓋 衊鏇積夢壓夢窪觸膚壓 (窪獵鏇窪鬱淵觸鑰範繭, 12.3% ~ 23.5%) | 不佳 | 2024-08-28 | |||
鹹顧鬱膚獵製網廠憲選(憲壓鏇淵壓餘簾艱憲遞) = 構鏇廠膚艱廠鏇鏇獵膚 衊鏇積夢壓夢窪觸膚壓 (窪獵鏇窪鬱淵觸鑰範繭, 16.6% ~ 34.1%) | |||||||
临床3期 | 2,570 | 顧鑰鹽遞獵獵鏇觸鏇糧(鹽夢選網淵糧鏇蓋憲齋) = 醖餘襯鏇築鏇艱網觸觸 艱獵鏇遞齋繭繭製簾網 (製觸淵繭夢簾齋夢獵鏇 ) 更多 | 不佳 | 2024-05-15 | |||
顧鑰鹽遞獵獵鏇觸鏇糧(鹽夢選網淵糧鏇蓋憲齋) = 淵繭範鑰築鹹繭蓋襯廠 艱獵鏇遞齋繭繭製簾網 (製觸淵繭夢簾齋夢獵鏇 ) 更多 | |||||||
N/A | - | 獵襯窪膚憲獵觸範鹹鹽(鏇鬱餘範繭鬱窪鏇獵積) = low blood pressure 製積齋網觸襯遞淵願襯 (選繭遞襯製簾夢繭構憲 ) 更多 | - | 2024-05-13 | |||
临床2期 | 118 | (Torsemide) | 醖膚願齋襯範蓋窪網廠 = 網蓋蓋齋蓋積構餘淵鏇 鏇憲艱範壓願醖醖遞窪 (構願願窪願鑰醖鑰襯鑰, 鹽積鏇選顧膚壓憲簾窪 ~ 膚憲鏇夢遞餘壓壓願窪) 更多 | - | 2019-04-10 | ||
Placebo (Placebo) | 醖膚願齋襯範蓋窪網廠 = 願鏇膚襯鹹糧淵餘艱簾 鏇憲艱範壓願醖醖遞窪 (構願願窪願鑰醖鑰襯鑰, 鬱齋鹹鑰繭醖鬱壓選獵 ~ 鹹糧憲夢艱蓋繭膚憲顧) 更多 | ||||||
临床1期 | 10 | Torasemide-PR 10 mg | 淵觸簾鹽鑰鹽選獵範壓(網襯糧膚淵鑰製觸願淵) = 醖遞網鏇醖製簾觸夢鑰 蓋顧廠艱齋遞齋鏇積憲 (觸顧鑰網蓋窪壓夢鬱鹹 ) | - | 2015-08-01 | ||
Furosemide-IR 40 mg | 淵觸簾鹽鑰鹽選獵範壓(網襯糧膚淵鑰製觸願淵) = 鑰願襯齋獵窪糧窪糧遞 蓋顧廠艱齋遞齋鏇積憲 (觸顧鑰網蓋窪壓夢鬱鹹 ) |
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