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项与 TIL therapy(Herlev Hospital) 相关的临床试验T Cell Therapy for Patients With Metastatic Renal Cell Carcinoma
Adoptive T cell therapy (ACT) with tumor infiltrating lymphocytes (TIL) has achieved impressive clinical results with durable complete responses in patients with metastatic melanoma. The TILs are isolated from patients own tumor tissue followed by in vitro expansion and activation for around 4-6 weeks. Before TIL infusion the patients receive 1 week of preconditioning chemotherapy with cyclophosphamide and fludarabine. After TIL infusion Interleukin-2 is administered to support T cell activation and proliferation in vivo.
Recent studies suggest, that TIL therapy works in other cancers than Metastatic Melanoma, including Renal Cell Carcinoma. In this study TIL therapy is administered to patients with metastatic Renal Cell Carcinoma.
T Cell Therapy for Patients With Metastatic Ovarian Cancer
Adoptive T cell therapy with tumor infiltrating lymphocytes (TIL) has achieved impressive clinical results with durable complete responses in patients with metastatic melanoma. The TILs are isolated from patients own tumor tissue followed by in vitro expansion and activation for around 4-6 weeks. Before TIL infusion the patients receive 1 week of preconditioning chemotherapy with cyclophosphamide and fludarabine. After TIL infusion Interleukin-2 is administered to support T cell acitivation and proliferation in vivo.
Recent studies suggest, that TIL therapy works in other cancers than Metastatic Melanoma, including Ovarian Cancer. In this study TIL therapy is administered to patients with metastatic Ovarian Cancer.
100 项与 TIL therapy(Herlev Hospital) 相关的临床结果
100 项与 TIL therapy(Herlev Hospital) 相关的转化医学
100 项与 TIL therapy(Herlev Hospital) 相关的专利(医药)
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项与 TIL therapy(Herlev Hospital) 相关的新闻(医药)5月2日,西比曼生物科技宣布与强生(Johnson & Johnson)旗下杨森(Janssen)公司达成一项全球独家合作,共同开发和商业化下一代新型CAR-T细胞治疗产品C-CAR039(靶向CD19/CD20)和C-CAR066(靶向CD20),用于治疗非霍奇金淋巴瘤(NHL)。根据协议,西比曼生物科技将获得2.45亿美元的首付款、潜在的里程碑付款和未来商业化后的销售分成。
西比曼生物科技是一家专注开发新型细胞疗法的全球创新生物制药公司。目前,该公司临床阶段的血液肿瘤产品包括靶向CD19/CD20的新型双靶点自体CAR-T细胞产品C-CAR039,靶向CD20的新型自体CAR-T细胞产品C-CAR066,以及特异性靶向B细胞成熟抗原(BCMA)的新型自体CAR-T细胞产品C-CAR088。该公司的实体瘤细胞治疗产品包括自体铠装抗肝癌特异性抗原GPC3 CAR-T细胞产品C-CAR031、肿瘤浸润T淋巴细胞(TIL)治疗产品C-TIL051。此外,西比曼生物科技还拥有多款新型针对血液肿瘤、实体瘤和自身免疫性疾病的临床前细胞产品。
根据协议条款,通过本次合作,杨森将获得C-CAR039和C-CAR066两款CAR-T细胞治疗产品在中国以外地区独家开发权,以及在中国地区开发的优先选择权。西比曼生物科技将获得2.45亿美元的首付款。在实现某些预定的临床开发、监管申报、商业化和销售里程碑后,西比曼生物科技还将获得多笔里程碑付款。商业化后,西比曼生物科技还将从杨森的净销售额中获得销售分成。
根据西比曼生物科技新闻稿,C-CAR039和C-CAR066均已获得美国FDA批准开展1b期临床试验。其中,C-CAR039还被FDA授予快速通道资格和再生医学先进疗法资格,用于治疗复发/难治性及弥漫性大B细胞淋巴瘤(r/rDLBCL)。此外,FDA还授予C-CAR039孤儿药资格,用于治疗滤泡性淋巴瘤(FL)。
西比曼生物科技董事长兼首席执行官(CEO)刘必佐先生表示,他们非常高兴地宣布与杨森达成关于C-CAR039和C-CAR066的独家合作协议,用于开发和商业化新型淋巴瘤CAR-T细胞疗法。C-CAR039和C-CAR066的最新临床数据继续显示出这两种细胞疗法在治疗复发/难治非霍奇金淋巴瘤方面的潜力,有望解决全球未满足的重大医疗需求。希望这次合作能让他们的非霍奇金淋巴瘤候选药物更及时有效地为全球患者提供服务。
参考资料:[1]西比曼生物科技宣布与杨森达成全球独家合作,共同开发和商业化下一代淋巴瘤CAR-T细胞治疗产品C-CAR039和C-CAR066. Retrieved May 02,2023, From https://mp.weixin.qq.com/s/QpRR0k6Om4geRfhhw4Jj_w
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100 项与 TIL therapy(Herlev Hospital) 相关的药物交易