贯叶连翘提取物(Hypericum perforatum Extract)

概要

基本信息

药物类型

中药

别名

Jarsin、SJW、St. John's Wort extract

+ [4]

靶点-

作用方式-

作用机制-

治疗领域

心血管疾病泌尿生殖系统疾病其他疾病

在研适应症-

非在研适应症

经前综合征子宫出血血管舒缩症

原研机构

Herbarium Laboratório Botânico Ltda

在研机构-

非在研机构

Herbarium Laboratório Botânico Ltda

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C30H16O8

InChIKeyBTXNYTINYBABQR-UHFFFAOYSA-N

CAS号548-04-9

关联

22

项与贯叶连翘提取物相关的临床试验

IRCT20241118063767N1

/ Suspended早期临床1期IIT

Investigating the Effect of Hypericum perforatum (Perforan) Tablets on Neurological Pain, Functional Independence and Severity of Depression in Patients with Spinal Cord Injuries

开始日期2025-01-19

申办/合作机构

Islamic Azad University

NCT04558697

/ Completed临床4期

Use of Vagitories Based on St. John's Wort, Tea Tree Oil and Shepherd's Purse in the Treatment of Vaginal Inflammation

There are more and more herbal preparations that are used for the purpose of treatment and improvement of the clinical picture of vaginitis by patients themselves, but also by healthcare professionals. Plant species, St. John's wort, chamomile, calendula, yarrow, shepherd's purse and tea tree oil are well known for there anti-inflammatory, antimicrobial and wound healing activity. This paper presents the results of a clinical study in which three herbal formulations/vagitories, based on extracts of above mentioned plant species, were investigated for their effectiveness on non-specific vaginitis.
This was randomized controlled clinical study that included 210 women with diagnosed non-specific vaginitis. Patients were divided into two basic groups, women in reproductive stage and postmenopausal stage. Three subgroups, containing approximately 30 patients each, received one of three vagitorie formulations for 5 days during which the effects on subjective and objective symptoms were monitored.

开始日期2019-03-21

申办/合作机构

University of Sarajevo

[+1]

NCT03796377

/ Completed临床1期

Effects of Hypericum Perforatum (St. John's Wort) on the Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Humans

Single-center, open-label, sequential treatment study to investigate the influence of the combined P-glycoprotein and CYP3A4 inducer hypericum perforatum on the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy volunteers.

开始日期2019-02-13

申办/合作机构

Insel Gruppe AG

[+1]

100 项与贯叶连翘提取物相关的临床结果

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100 项与贯叶连翘提取物相关的转化医学

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100 项与贯叶连翘提取物相关的专利（医药）

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2,624

项与贯叶连翘提取物相关的文献（医药）

2025-04-10·Journal of Applied Polymer Science

Thermoplastic Polyurethane/Polylactic Acid Blend Foams Loaded With Curcuma longa L. and Hypericum perforatum Extracts Towards Wound Dressing Applications

作者: Popa, Andreea Daniela ; Bužarovska, Aleksandra ; Stanoeva, Jasmina Petreska ; Karamanolevski, Predrag ; Avérous, Luc ; Dinescu, Sorina

ABSTRACTThis study aimed to fabricate and evaluate TPU/polylactic acid foams loaded with natural extracts of Curcuma longa L. (C) and Hypericum perforatum (H) for WD application. In the frame of the structure/properties relationships study, different and complementary analyzes for WD materials, such as water contact angles measurements, water vapor transmission rate, water absorption, and extracts release studies were performed, in connection with the structural and thermal characterizations performed using scanning electron microscopy, differential scanning calorimetry and Fourier transform spectroscopy. The water absorption capacity of the blank blend foam and foams loaded with extracts (C and H) was found to be in the range of 8.31% ± 0.27, 90.7% ± 4.1 and 164% ± 4.0%, respectively. The loaded foams presented cumulative extracts release of 45.5% ± 2% (C) and 100% ± 1.1% (H) within 96 h and acceptable water vapor transmission rate in the range of 2088 ± 66 and 3520 ± 991 g·m−2·24 h−1, respectively. Summary, the investigated foams, enriched with both extracts, showed excellent performances in agreement with WD materials requirements, higher cell viability and proliferation compared to the reference foams, as well as non‐cytotoxic effects on human fibroblasts in experimental conditions.

2025-03-04·Journal of Burn Care & Research

Comparison of the Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Wounds

Article

作者: Turan Canbaz, Esra ; Alp, Hamit Hakan ; Mercantepe, Tolga ; Ragbetli, Murat Cetin ; Erten, Remzi ; Canbaz, Yasin ; Yüce, Serdar ; Karakol, Percin ; Turel, Idris

AbstractWe aimed to compare the effectiveness of thymoquinone (TQ), the most important bioactive component of black cumin, St. John wort (SJW) oil, a traditional medicinal plant used in burns, and silver sulfadiazine (AgSD), a well-known antiinflammatory agent used in modern medicine, in an experimental burn rat-model. Sixty-three Wistar-Albino rats were randomly divided into 9 groups (n = 7). TQ and SJW were administered topically and systemically but AgSD was applied topically. Epithelialization, inflammatory cell response, granulation tissue, vascularization, and fibrosis were evaluated. Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), vitamin E, 8-hydroxy-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10) were analyzed in serum. Topical TQ accelerated the epithelialization, enabled granulation, vascularization, and fibrosis in wounds (P = .001). Topical and systemic TQ increased Vitamin E levels (P = .003) but reduced TOS and 8-OHdG levels (P = .001). Topical SJW reduced granulation and vascularization. Topical and systemic SJW decreased TOS, MDA, and 8-OHdG levels (P = .001) but increased TAS (P = .001) and Vitamin E levels (P = .003). Topical AgSD reduced TOS, 8-OHdG, and MDA levels (P = .001). Topical and systemic TQ demonstrated significant advantages in accelerating the wound healing process while also enhancing antioxidant defenses and reducing oxidative damage. SJW oil, particularly in topical application, improved epithelialization, and antioxidant status but showed less efficacy in systemic use. AgSD, while effective in reducing oxidative stress, was less successful in promoting wound healing and appeared to delay granulation and fibrosis. Thymoquinone offers superior protective and healing benefits, SJW is effective locally but less so systemically, and AgSD should be used cautiously, potentially combined with antioxidants to mitigate its negative impact on wound healing.

2025-01-01·Journal of Plant Growth Regulation

The Regulation Mechanism of MYC on MeJA-Induced Flavonoids Synthesis in Dendrobium officinale

作者: Meng, Wenna ; Xu, Mengyao ; Jia, Yue ; Tan, Mingpu ; Hu, Gang ; Zhang, Yu ; Fan, Xiangqian ; Ding, Anping ; Chen, Guihong ; Xiang, Zengxu

MYC transcription factors belong to a subfamily of bHLH clade.MYCs play important roles in regulating plant growth and development as well as secondary metabolite synthesis in multiple species.However, there is no complete identification and anal. of the MYC genes family in the perennial epiphytic herb Dendrobium officinale.In this study, 12 MYC transcription factors (DoMYCs) were identified in D. officinale and divided into 4 groups according to the phylogenetic anal.Particularly, DoMYC2, DoMYC5, DoMYC8 and DoMYC11 contained a Jasmonate ZIM-domain (JAZ) interaction domain (JID) and a transcriptional activation domain (TAD) in the bHLH-MYC_N region.Furthermore, the DoMYCs promoter region harbored many cis elements for light response, hormone response, stress response, and flavonoid synthesis.To investigate whether MYC and jasmonate (JA) are involved in regulating flavonoids synthesis in D. officinale, we treated the plant with Me jasmonate (MeJA) to explore the expression of genes involved in flavonoid biosynthesis (DoCHS8, DoF3H, DoANS, DoAOC3, DoAOS2L, DoLOX5.2 and DoMYCs).The results manifested that MeJA treatments affected the expression of MYC transcription factors, the key genes in flavonoid and JA biosynthesis pathways, leading to enhanced synthesis and accumulation of anthocyanins, rutin, hypericin and isoquercitrin in D. officinale pseudobulb.The further correlation anal. revealed a confidential relationship among MeJA-MYC-flavonoids in D. officinale.This study strengthened the function of MYC on MeJA-induced flavonoids synthesis in D. officinale, and the uncovered MeJA-MYC-flavonoids circuit provided a mol. basis for further investigation on the regulatory mechanism of jasmonate (JA) on secondary metabolism in medicinal plants.

100 项与贯叶连翘提取物相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	贯叶连翘提取物	-	DB13014

研发状态

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适应症	最高研发状态	国家/地区	公司	日期
经前综合征	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01
子宫出血	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01
血管舒缩症	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00048815 (CTgov)	N/A	抑郁症	73	Citalopram (Citalopram)	衊憲艱壓衊廠襯繭獵觸(願餘觸觸鏇製憲繭獵網) = 壓糧網鹹壓蓋淵艱壓願積鹽齋鹽顧鏇願觸選窪 (願鹽鹽鬱窪選獵壓鏇蓋, 憲窪膚遞窪夢膚願糧鏇 ~ 壓構鹽餘糧廠夢淵膚鑰) 更多	-	2018-05-11
				St. John's Wort (St. John's Wort)	衊憲艱壓衊廠襯繭獵觸(願餘觸觸鏇製憲繭獵網) = 選廠壓簾遞築壓艱選壓積鹽齋鹽顧鏇願觸選窪 (願鹽鹽鬱窪選獵壓鏇蓋, 製顧選築鑰鹽淵鹹蓋鹽 ~ 壓範壓獵憲壓網顧構衊) 更多
NCT00110136 (CTgov)	临床2期	潮热 \| 乳腺癌	9	St. John's Wort	網膚鬱鏇憲糧衊淵餘廠(獵築鹽鬱襯鏇積鏇夢觸) = 遞餘選簾夢願餘淵鏇鹽選顧構積窪鬱壓齋選鹽 (築餘壓餘糧餘鬱鏇鏇艱, 選構顧獵簾製鹹鬱選壓 ~ 壓製淵廠顧範製鹹淵獵) 更多	-	2014-12-29
EASD2012	N/A	-	-	St. John's Wort extract	壓築積繭範繭鏇鏇遞膚(壓壓鹹夢鑰願繭鑰遞願) = partially corrected the cytokine-induced unbalance between anti- and pro-apoptotic factors 衊憲鏇築鹽襯艱衊鏇淵 (簾衊範鏇鬱膚繭膚襯積 ) 更多	积极	2012-10-04
				Hyperforin
NCT00587860 (CTgov)	临床2期	肠易激综合征	70	St. John's wort (St. John's Wort)	夢糧齋蓋築願蓋觸壓獵(繭淵餘獵願餘廠顧鑰選) = 壓襯憲淵夢鏇遞蓋獵廠鹽遞遞網夢顧膚遞憲構 (糧網蓋膚鏇醖醖壓窪夢, 憲齋蓋艱願鬱簾鹽鏇襯 ~ 獵選鹹網顧衊簾鏇鏇夢) 更多	-	2010-03-01
				Placebo (Placebo)	夢糧齋蓋築願蓋觸壓獵(繭淵餘獵願餘廠顧鑰選) = 鏇網糧夢繭顧淵糧鑰齋鹽遞遞網夢顧膚遞憲構 (糧網蓋膚鏇醖醖壓窪夢, 構鹹膚獵醖遞網觸蓋鹽 ~ 遞範鑰製鹽糧鏇鑰觸壓) 更多