更新于：2024-12-14
Trihexyphenidyl Hydrochloride
盐酸苯海索
更新于：2024-12-14
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1949-05-13), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构
分子式C20H32ClNO |
InChIKeyQDWJJTJNXAKQKD-UHFFFAOYSA-N |
CAS号52-49-3 |
关联
16
项与 盐酸苯海索 相关的临床试验Pharmacogenomic Contribution to the Biotransformation of Trihexyphenidyl and Development of a Precision Dosing Model for Children With Dystonia and Cerebral Palsy
盐酸苯海索片在健康受试者中单中心、随机、开放、两制剂、单次给药、两周期、双交叉空腹/餐后生物等效性试验
盐酸苯海索片在健康受试者中单中心、开放、均衡、随机、单剂量、双周期、双交叉空腹和餐后状态下的生物等效性试验
100 项与 盐酸苯海索 相关的临床结果
登录后查看更多信息
100 项与 盐酸苯海索 相关的转化医学
登录后查看更多信息
100 项与 盐酸苯海索 相关的专利（医药）
登录后查看更多信息
939
项与 盐酸苯海索 相关的文献（医药）2024-12-01Journal of Pediatric Genetics
A Rare Case of Neuronal Ceroid Lipofuscinosis-Type 1 (NCL-1) with Vitamin D-Dependent Rickets-Type 1 (VDDR-1), Complex 1 Mitochondrial Deficiency, and Mixed Variant—Checkerboard and Phylloid Type of Pigmentary Mosaicism
Article
作者: Srinivas, Sahana M. ; Chikara, Surendra K. ; Santhoshkumar, Rashmi ; Chickabasaviah, Yasha ; Gowda, Vykuntaraju K. ; Vishwanathan, Gurudatta Baraka ; Vamyanmane, Dhananjaya K. ; Mittal, Pallavi ; Srinivasan, Varunvenkat M. ; K., Anusha Raj
Abstract:
Introduction Neuronal ceroid lipofuscinosis-type 1 (NCL-1) is a neurodegenerative lysosomal storage disorder. Vitamin D-dependent rickets type 1 (VDDR-1) is a rare cause of refractory rickets. Here, we report an unusual association of NCL-1 with VDDR-1.
Case A 3-year-old boy presented with a history of seizures from 45 days of life, delayed development, and loss of attained milestones at 20 months of age, along with progressive vision impairment since 1 year. Examination showed a failure to thrive, microcephaly, rachitic rosary, checkerboard and phylloid type of pigmentary mosaicism, fundus showed disc pallor with generalized narrowing of arterioles, bilateral retinitis pigmentosa, spasticity and dystonia, brisk reflexes, extensor plantar, and left choreoathetoid movements. Investigations showed hypocalcemia (7.8 mg/dL), normal phosphorus (3.9 mg/dL), elevated alkaline phosphatase (508.8 U/L), elevated parathyroid hormone (513.35 pg/mL), low 1,25-dihydroxy-vitamin D (9.93 pg/mL), and normal renal function. The child had metabolic acidosis, elevated ammonia (403.9 micromol/L), lactate (95 mg/dL, normal range 4.5–19.8 mg/dL), and creatine phosphokinase (432 U/L) level, and normal tandem mass spectroscopy. X-ray wrist showed healing vitamin deficiency rickets. Abnormal electroencephalogram was suggestive of low voltage activity. Magnetic resonance imaging brain showed gross cerebral and cerebellar atrophy. A muscle biopsy showed scattered atrophic fibers and several ultrastructural granular osmiophilic deposits and some mitochondrial aggregates of varying size were observed. Mitochondrial respiratory chain enzyme assay exhibited complex-1 deficiency (activity < 30%). Genetic analysis showed two pathogenic mutations: homozygous nonsynonymous variation c.674T > C in exon 7 of the PPT1 gene and a homozygous frameshift variation c.1178_1179delAA in exon 7 of CYP27B1 confirming the diagnosis of NCL-1 with VDDR-1. The child was treated with a low protein diet, levetiracetam, clonazepam, trihexyphenidyl, haloperidol, calcium supplement, calcitriol, and sodium benzoate; some improvement in clinical and biochemical parameters was noted on follow-up.
Conclusion This is a novel association of NCL-1 with VDDR-1 associated with complex-1 mitochondrial deficiency which has previously not been reported in the literature.
2024-12-01Asian Journal of Psychiatry
Addressing the misuse and abuse of trihexyphenidyl
Letter
作者: Okeleji, Lateef Olabisi ; Ajayi, Ayodeji Folorunsho ; Folorunsho, Ajayi Ayodeji ; Okeleji, Olabisi Lateef
2024-11-10West African journal of medicine
CONTRIBUTION OF PHYSIOTHERAPY IN PSYCHIATRY: CASE OF A PATIENT SUFFERING OF DYSTONIA DUE TO ANTIPSYCHOTICS AT THE SAINT JOHN OF GOD MENTALHEALTH CENTRE IN LOMÉ-TOGO.
Article
作者: Patayodi, E P ; Affo, C ; Salifou, S ; Atchou, B ; Kanekatou, S ; Sossa, A S ; Dassa, K S
Introduction:
Antipsychotic-induced dystonia is a neurological side-effect and can be very disabling. Treatment is multidisciplinary, including physiotherapy.
Objective:
The aim was to show the contribution of physiotherapy in the management of people suffering from dystonia secondary to antipsychotics.
Method:
The Saint John of God Mental Health Centre in Lomé was used as the study setting. This involved a descriptive study about a case of cervical dystonia induced by antipsychotics, from 13 July to 30 August 2020.
Results:
Our observation concerned a male patient, aged 55 years, suffering from a persistent delirious disorder, on a poorly documented treatment, admitted for cervical dystonia and persistent delirium. A physiotherapy assessment revealed neck pain rated at 5/10, reduced neck muscle strength, and an inability to keep the neck stable at rest. He was started on olanzapine 20mg tablet a day, haloperidol decanoas injectable 50mg/month, and trihexyphenidyl 5mg tablet in the morning. Physiotherapy treatment consisted of 14 sessions using various techniques including passive-active stretching of the neck and head muscles. The evolution was marked by a significant regression of involuntary neck movements and an improvement in the patient's quality of life.
Conclusion:
Physiotherapy should be more involved in the management of dystonia in psychiatric practice.
100 项与 盐酸苯海索 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 药物导致的静坐不能 | 日本 | 1953-08-18 | |
| 运动失调 | 日本 | 1953-08-18 | |
| 帕金森病 | 美国 | 1949-05-13 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用