预约演示
更新于：2025-12-07
Betamethasone Sodium Phosphate
磷酸钠倍他米松
更新于：2025-12-07
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C22H30FNa2O8P |
InChIKeyODEOTKLZVXBMJD-LWCNAHDDSA-N |
CAS号151-73-5 |
关联
24
项与 磷酸钠倍他米松 相关的临床试验NCT07078786
Comparison of Effect of Antenatal Dexamethasone Versus Betamethasone on Antepartum Cardiactocography
ChiCTR2500096518
Randomized controlled study of improving preterm birth outcomes by reducing prenatal corticosteroid exposure
ISRCTN38950110
Comparison of the analgesic non-inferiority of ultrasound-guided injections of ACS (Orthokine) into the cervical fascial planes versus application along the cervical facet joints in patients with neck pain: A randomized, open-label, controlled clinical trial. (Protocol).
100 项与 磷酸钠倍他米松 相关的临床结果
登录后查看更多信息
100 项与 磷酸钠倍他米松 相关的转化医学
登录后查看更多信息
100 项与 磷酸钠倍他米松 相关的专利（医药）
登录后查看更多信息
1,069
项与 磷酸钠倍他米松 相关的文献（医药）2026-01-01NUTRITION
Enteroendocrine hormonal response after the ingestion of cola beverages with sucrose and non-nutritive sweeteners in healthy adults: A randomized crossover trial
Article
作者: Klünder-Klünder, Miguel ; Miranda-Lora, América L ; López-Martínez, Briceida ; Vilchis-Ordoñez, Armando ; Galicia-Ayala, César
OBJECTIVE:
The evidence of the effects of non-nutritive sweeteners (NNS) on glucose-regulating hormones is heterogeneous. We aimed to evaluate the acute effects of three types of soft drinks sweetened with sucrose and/or NNS on glucose and hormone responses.
METHODS:
We conducted a randomized crossover clinical trial involving 20 adults. Participants ingested 355 mL of carbonated water (CON) and three beverages sweetened with aspartame/acesulfame K (AAK), sucrose/stevia (SUC/STE), and sucrose (SUC), with a 7-day washout period between each trial. Glucose, insulin, glucagon, glucose-dependent insulinotropic peptide (GIP), pancreatic polypeptide (PP), leptin, and ghrelin levels were measured at 0, 30, 60, 90, and 120 minutes, in addition to the area under the curve (AUC).
RESULTS:
The SUC beverage elicited the highest glucose and insulin responses, with significant increases at 30 minutes (P < 0.001). In contrast, SUC/STE resulted in a glucose-lowering effect at 60 minutes (-12.5 mg/dL, P < 0.05) and a sustained increase in PP levels, which peaked at 120 minutes (+73.4 pg/mL, P < 0.05). AAK and CON showed no significant differences in glucose or hormone levels.
CONCLUSION:
This study highlights the differential effects of sucrose- and NNS-sweetened beverages on glucose metabolism and hormonal responses. The glucose-lowering and PP-stimulating effects of SUC/STE suggest potential benefits for glycemic control and satiety. These findings provide insights into the metabolic impact of NNS and their potential role in dietary recommendations for health promotion.
2025-12-01INTERNATIONAL DENTAL JOURNAL
Control of Viral Aerosol Dispersion During Simulated Dental Procedures
作者: Forero, Manuel ; Allison, James R. ; Calvo, Eliana P. ; Castellanos, Jaime E. ; Holliday, Richard ; Beltrán, Edgar O. ; Martignon, Stefania ; Velandia-Romero, Myriam L. ; Jakubovics, Nicholas S.
AIM:
Although air-cleaning systems (ACS) and high-volume evacuation (HVE) have been shown to reduce dental bioaerosols, few works have looked at viruses. This study aimed to assess the effects of HVE and ACS on dispersion of aerosolised particles and airborne viruses in a simulation model of dental bioaerosols using a detailed and comprehensive sampling approach and different tracer molecules.
METHODS:
MS2 bacteriophage and fluorescein solution were used as viral or dispersion tracers, respectively. These were added independently to the instrument irrigation system and aerosolised during dental procedures. Aerosol mitigation condition groups were ACS, HVE, ACS plus HVE, and No mitigation (control). Aerosols were collected via settlement onto sterile filter papers and agar plates. In addition, a 6-stage Andersen cascade impactor was used for viral air sampling. Fluorescent particles were analysed using ImageJ software, and bacteriophage was quantified using plaque assays and reverse transcription quantitative polymerase chain reaction (RT-qPCR).
RESULTS:
HVE combined with ACS produced the highest reduction in viral spread among the three aerosol-generating procedures (AGPs). This reduction was evident both in the number of fluorescent particles and that of viruses. The effect was more pronounced at the farthest sites. By plaque assay, viral loads in the largest-sized aerosols (>7.0 μm) from air samples were 93% lower in the ACS plus HVE group compared with control, and the load in the smallest aerosols (0.65-1.1 μm) was reduced by 84% (P < .05). By RT-qPCR, the ACS plus HVE group also reduced viral detection in air samples (>80%) more than ACS or HVE alone compared with the control group (P < .05). In ACS or HVE condition, viral RNA was detected even in the absence of infectious virus detected by plaque assay for anterior versus posterior procedures and in the farthest positions.
CONCLUSIONS:
A synergistic effect was obtained in the reduction of aerosolised particles and viruses from surfaces and air samples when HVE was combined with ACS.
CLINICAL RELEVANCE:
Using a comprehensive and depth assessment, this study found that the combination of high-volume evacuation and air-cleaning systems was the most effective measure in mitigating virus dispersion during aerosol-generating dental procedures, translated into lower required waiting (fallow) times between patients' appointments for dental care depending on the type of AGP conducted. The more aerosols are produced during an AGP, the longer it takes to prevent cross-contamination among dental staff and patients. In addition, our findings support the use of HVE, face shields, and well-fitting masks in dental procedures, not only during pandemics but also in everyday practice.
2025-12-01European Journal of Obstetrics & Gynecology and Reproductive Biology
Antenatal corticosteroid exposure in term infants and neonatal respiratory failure: A population based cohort study
Article
作者: Zhou, Jianguo ; Chen, Yuanyuan ; Bu, Xinghe
BACKGROUND AND OBJECTIVES:
Antenatal corticosteroids (ACS) exposure in term infants potentially cause short and long-term negative consequence. This study aims to estimate the prevalence of ACS exposure among term infants, identify associated risk factors, and assess the impact on neonatal respiratory failure (NRF).
METHODS:
A population-based, retrospective cohort analysis was conducted using the 2022 National Vital Statistics System data from USA, focusing on term infants (37-41 weeks' gestation). We defined ACS exposure based on any record of corticosteroid administration to the mother before delivery. Logistic regression models analyzed the risk factors of ACS exposure while propensity score matching(PSM) were used to evaluate the association between ACS exposure and NRF.
RESULTS:
Of the 2,883,280 term infants studied, 34,986 (1.2 %) were exposed to ACS. Logistic regression model demonstrated that factors significantly linked to ACS exposure (adjusted Odds Ratios, aORs > 2) included multiple gestation (aOR 2.36, 95 % CI 2.26-2.46), lower gestational age (37 weeks vs. 39 weeks, aOR 3.92, 95 % CI 3.81-4.04), and SGA status (aOR 3.72, 95 % CI 3.63-3.81). After PSM, ACS-exposed infants exhibited a higher risk of NRF compared to non-exposed infants (3.9 % vs. 1.6 %; OR 2.58, 95 % CI 2.34-2.85; p < 0.001). Subgroup analyses demonstrated a consistent elevation of NRF risk associated with ACS exposure across various gestational ages, delivery methods, and maternal health conditions.
CONCLUSION:
ACS exposure occurs in a notable percentage of term births and is associated with increased risks of NRF, challenging the primary objective of ACS use in term infants. The findings underline the need for more cautious and targeted administration of ACS to avoid unnecessary exposure and mitigate adverse outcomes in term infants.
100 项与 磷酸钠倍他米松 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 溃疡性结肠炎 | 日本 | 1992-03-13 | |
| 克罗恩病 | 日本 | 1992-03-13 | |
| 睑缘炎 | 日本 | 1985-11-20 | |
| 结膜炎 | 日本 | 1985-11-20 | |
| 角膜炎 | 日本 | 1985-11-20 | |
| 耳炎 | 日本 | 1985-11-20 | |
| 炎症 | 美国 | 1974-12-31 | |
| 胶原蛋白疾病 | 日本 | 1973-01-31 | |
| 内分泌系统疾病 | 日本 | 1973-01-31 | |
| 心脏衰竭 | 日本 | 1973-01-31 | |
| 肾病综合征 | 日本 | 1973-01-31 | |
| 类风湿关节炎 | 日本 | 1973-01-31 | |
| 眼部炎症 | 日本 | 1964-10-07 | |
| 外耳炎 | 日本 | 1964-10-07 | |
| 中耳炎 | 日本 | 1964-10-07 | |
| 过敏性鼻炎 | 日本 | 1964-10-07 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 139 | (SURF-200 (0.02% Betamethasone Sodium Phosphate in Vehicle)) | 鹹窪齋願鑰願衊艱獵鬱 = 構鹽顧憲觸膚範觸繭餘 願齋醖蓋窪膚製願鹽選 (膚糧鹹鹽製範壓顧願艱, 鑰範餘製蓋範願艱鏇鑰 ~ 窪糧蓋壓鑰鏇齋築鏇衊) 更多 | - | 2025-06-04 | ||
(SURF-200 (0.04% Betamethasone Sodium Phosphate in Vehicle)) | 鹹窪齋願鑰願衊艱獵鬱 = 窪壓構齋醖齋鏇糧積衊 願齋醖蓋窪膚製願鹽選 (膚糧鹹鹽製範壓顧願艱, 築鹽獵醖襯積簾觸襯夢 ~ 選觸製夢淵範願蓋膚窪) 更多 | ||||||
临床2期 | 1 | (Bupivacaine Hydrochloride and Betamethasone Sodium Phosphate) | 醖簾獵淵顧選窪壓憲壓(遞餘齋蓋製醖鑰壓艱窪) = 遞淵廠憲襯襯選築膚齋 夢獵範網積蓋顧鬱衊築 (鬱淵製壓遞醖窪簾顧網, 糧築簾網網觸範獵夢鑰 ~ 願願鬱觸積餘衊糧窪窪) 更多 | - | 2020-11-02 | ||
(Bupivacaine Hydrochloride) | 醖簾獵淵顧選窪壓憲壓(遞餘齋蓋製醖鑰壓艱窪) = 鹽構製艱構積鑰衊糧鹹 夢獵範網積蓋顧鬱衊築 (鬱淵製壓遞醖窪簾顧網, 選廠餘糧顧繭蓋鹽觸衊 ~ 網構選廠醖鏇範鑰築獵) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用