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更新于：2026-03-11
Betamethasone Sodium Phosphate
磷酸钠倍他米松
更新于：2026-03-11
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C22H30FNa2O8P |
InChIKeyODEOTKLZVXBMJD-LWCNAHDDSA-N |
CAS号151-73-5 |
关联
29
项与 磷酸钠倍他米松 相关的临床试验NCT07078786
Comparison of Effect of Antenatal Dexamethasone Versus Betamethasone on Antepartum Cardiactocography
ChiCTR2500096518
Randomized controlled study of improving preterm birth outcomes by reducing prenatal corticosteroid exposure
ChiCTR2300078591
Clinical study of dorsal root ganglion pulse radiofrequency combined with sympathetic nerve radiofrequency in treatment of acute herpes zoster neuralgia
100 项与 磷酸钠倍他米松 相关的临床结果
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100 项与 磷酸钠倍他米松 相关的转化医学
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100 项与 磷酸钠倍他米松 相关的专利（医药）
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1,005
项与 磷酸钠倍他米松 相关的文献（医药）2026-04-01Materials Today Bio
Injectable anti-inflammatory, antioxidant supramolecular nanofiber hydrogel for peripheral nerve injury repair and neuropathic pain relief
Article
作者: Zhang, Ye ; Hu, Xianwen ; Zhang, Xiaojun ; Sheng, Kui ; Samdrup, Tsring ; Wang, YaGuang ; Su, Haitao ; Weng, LiJun ; Liu, Anqi ; Zhao, XinYang ; Li, Huihui
Patients with peripheral nerve injury (PNI) often experience neuropathic pain (NP), which is difficult to treat effectively due to ongoing inflammation and oxidative stress that impede nerve repair. Traditional anti-inflammatory antioxidants are limited by short half-lives and significant side effects. This study introduces a supramolecular hydrogel formed by combining anti-inflammatory betamethasone phosphate (Betp) with calcium chloride to create betamethasone phosphate hydrogel (Betp@Gel). The antioxidant curcumin (Cur) was incorporated into this gel to form Cur/Betp@Gel, which can be injected directly at the injury site for sustained Cur release. Cur/Betp@Gel demonstrates superior sustained-release capabilities and therapeutic effectiveness compared to Betp@Gel or Cur alone. It enhances pain relief, supports functional recovery after nerve damage, and promotes nerve repair and regeneration. This is achieved by Betp@Gel's anti-inflammatory effects, which inhibit TNF-α, IL-1β, and IL-6, combined with Cur's continuous slow release, which scavenges reactive oxygen species (ROS). Additionally, Cur/Betp@Gel mitigates PNI-induced spinal inflammation by reducing GFAP and Iba-1 expression in the spinal cord. Overall, in-situ injection of Cur/Betp@Gel is a promising strategy for aiding nerve repair and alleviating neuropathic pain.
2026-04-01FOOD CHEMISTRY
Pea protein-steviol glycosides complexes: Fabrication, characterization and evaluation for the emulsifying capacity
Article
作者: Pei, Enqi ; Wang, Cuina ; Yu, Rongrong ; Xia, Jingyu ; Zhang, Min ; Xu, Mingfeng ; Wang, Wen
Mixtures of pea protein isolate (PPI, 2%) and steviol glycosides (STE, 0.1% ∼ 1%) were prepared, characterized, and assessed for emulsifying ability. Critical micelle concentration of STE increased from 0.49% (pure STE) to 0.60% (PPI-STE complex). Molecular docking and fourier transform infrared spectroscopy showed that hydrophobic interactions and hydrogen bonds drove complexation. STE above 0.6% significantly increased complex surface hydrophobicity and altered PPI tertiary/secondary structure (reduced α-helix, increased β-sheet). Incorporation of STE reduced the interfacial tension of PPI and decreased the number of adsorbed proteins at the interface with the great change happened above 0.6%. Emulsions with PPI-STE had decreased particle size and increased zeta potential (up to 0.6% STE), exhibiting enhanced stability against ionic strength (100-300 mM NaCl), pH (3-7), and storage (28 days at 4 °C). These findings highlight the potential of PPI-STE complexes especially with STE above the critical micelle concentration as natural, high-performance emulsifiers for sustainable food applications.
2026-03-01MOLECULAR IMMUNOLOGY
Sophora tonkinensis reprograms tumor-associated macrophages to M1-like phenotype and exerts anti-hepatocellular carcinoma effects
Article
作者: Huang, Siqi ; Guo, Yuanyuan ; Bai, Zhaofang ; Zhan, Xiaoyan ; Wen, Jincai ; Liu, Lu ; Huang, Ang ; Chen, Xiaoyan ; Zhao, Jun ; He, Caiping ; Xiao, Xiaohe ; Lu, Zongliang ; Wang, Xianling
ETHNOPHARMACOLOGICAL RELEVANCE:
Sophora tonkinensis radix et rhizoma is a medicinal herb traditionally used to treat inflammatory diseases and various types of cancer, previous phytochemistry studies have identified abundant alkaloids and flavonoids as the major bioactive components with anti-inflammatory, anti-tumor, hepatoprotective and immunomodulatory pharmacological effects, but their effects on Tumor-associated macrophages (TAMs) and the tumor immune microenvironment have not been systematically explored.
AIM OF THE STUDY:
This work aimed to establish whether a standardized extract of Sophora tonkinensis (STE) can halt IL-4-driven M2 macrophage polarization, reprogram established M2-like tumor-associated macrophages toward a pro-inflammatory M1-like phenotype, and clarify the underlying molecular mechanisms and in vivo efficacy of these immunomodulatory actions.
MATERIALS AND METHODS:
Bone-marrow-derived macrophages (BMDMs) were polarized to an M2 phenotype and subsequently treated with STE. Expression of the M1/M2 markers Arg-1, CD206, iNOS, and CD86 in these macrophages was quantified by immunoblotting, qPCR, and flow cytometry. The impact of STE-pretreated M2-conditioned medium on the proliferation, migration, and invasion of Hepa 1-6 cells was then examined. H22 cells were subcutaneously inoculated into Balb/c mice to assess STE's effects on the macrophage landscape within the tumor immune microenvironment and to evaluate its antitumor efficacy.
RESULTS:
STE dose-dependently suppressed IL-4-induced Arg-1 and CD206 while up-regulating iNOS and CD86, indicating a blockade of M2 polarization and a shift toward an M1 signature. Mechanistically, STE markedly increased JAK1 and STAT1 phosphorylation. Functionally, it potently inhibited invasion and migration of Hepa 1-6 cells. In tumor-bearing mice, robust suppression of tumor growth was accompanied by a pronounced reduction in M2-like TAMs and a reciprocal increase in M1-like macrophages within the tumor microenvironment.
CONCLUSION:
STE reprograms TAMs via the JAK1/STAT1 axis and exhibits robust antitumor activity, underscoring its promise as a natural, macrophage-targeted immunotherapeutic that warrants further investigation for integration into cancer treatment strategies.
100 项与 磷酸钠倍他米松 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 溃疡性结肠炎 | 日本 | 1992-03-13 | |
| 克罗恩病 | 日本 | 1992-03-13 | |
| 睑缘炎 | 日本 | 1985-11-20 | |
| 结膜炎 | 日本 | 1985-11-20 | |
| 角膜炎 | 日本 | 1985-11-20 | |
| 耳炎 | 日本 | 1985-11-20 | |
| 炎症 | 美国 | 1974-12-31 | |
| 胶原蛋白疾病 | 日本 | 1973-01-31 | |
| 内分泌系统疾病 | 日本 | 1973-01-31 | |
| 心脏衰竭 | 日本 | 1973-01-31 | |
| 肾病综合征 | 日本 | 1973-01-31 | |
| 类风湿关节炎 | 日本 | 1973-01-31 | |
| 眼部炎症 | 日本 | 1964-10-07 | |
| 外耳炎 | 日本 | 1964-10-07 | |
| 中耳炎 | 日本 | 1964-10-07 | |
| 过敏性鼻炎 | 日本 | 1964-10-07 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 139 | (SURF-200 (0.02% Betamethasone Sodium Phosphate in Vehicle)) | 顧鏇膚網鏇願糧壓鬱蓋 = 糧窪糧遞衊糧廠鑰蓋艱 餘積鬱餘醖廠夢鏇夢淵 (艱餘積製鑰鏇襯顧觸鹽, 餘簾獵鑰衊壓選餘鑰鹹 ~ 願壓網獵獵廠餘願鹹願) 更多 | - | 2025-06-04 | ||
(SURF-200 (0.04% Betamethasone Sodium Phosphate in Vehicle)) | 顧鏇膚網鏇願糧壓鬱蓋 = 齋繭衊築衊選鬱構艱觸 餘積鬱餘醖廠夢鏇夢淵 (艱餘積製鑰鏇襯顧觸鹽, 蓋積鏇鑰網顧憲膚鏇齋 ~ 築鏇廠範獵餘壓衊醖鑰) 更多 | ||||||
临床2期 | 1 | (Bupivacaine Hydrochloride and Betamethasone Sodium Phosphate) | 艱廠壓製夢鹹醖鹹遞構(網蓋鹹觸壓鑰鑰鏇鬱鬱) = 製願憲窪壓醖願製淵艱 顧鑰積夢壓襯獵築夢繭 (製遞鹹窪夢夢繭築醖簾, 製網醖蓋艱顧鬱選積壓 ~ 鹽網範製鹽繭膚積遞觸) 更多 | - | 2020-11-02 | ||
(Bupivacaine Hydrochloride) | 艱廠壓製夢鹹醖鹹遞構(網蓋鹹觸壓鑰鑰鏇鬱鬱) = 範膚襯壓築鬱鏇鏇鏇餘 顧鑰積夢壓襯獵築夢繭 (製遞鹹窪夢夢繭築醖簾, 選糧積憲簾築鹽選製鑰 ~ 範簾淵鏇餘壓簾襯鑰觸) 更多 |
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