预约演示
更新于：2025-12-17
Betamethasone Sodium Phosphate
磷酸钠倍他米松
更新于：2025-12-17
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C22H30FNa2O8P |
InChIKeyODEOTKLZVXBMJD-LWCNAHDDSA-N |
CAS号151-73-5 |
关联
27
项与 磷酸钠倍他米松 相关的临床试验NCT07078786
Comparison of Effect of Antenatal Dexamethasone Versus Betamethasone on Antepartum Cardiactocography
ChiCTR2500096518
Randomized controlled study of improving preterm birth outcomes by reducing prenatal corticosteroid exposure
ChiCTR2300078591
Clinical study of dorsal root ganglion pulse radiofrequency combined with sympathetic nerve radiofrequency in treatment of acute herpes zoster neuralgia
100 项与 磷酸钠倍他米松 相关的临床结果
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100 项与 磷酸钠倍他米松 相关的转化医学
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100 项与 磷酸钠倍他米松 相关的专利（医药）
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1,074
项与 磷酸钠倍他米松 相关的文献（医药）2026-01-01NUTRITION
Enteroendocrine hormonal response after the ingestion of cola beverages with sucrose and non-nutritive sweeteners in healthy adults: A randomized crossover trial
Article
作者: Klünder-Klünder, Miguel ; Miranda-Lora, América L ; López-Martínez, Briceida ; Vilchis-Ordoñez, Armando ; Galicia-Ayala, César
OBJECTIVE:
The evidence of the effects of non-nutritive sweeteners (NNS) on glucose-regulating hormones is heterogeneous. We aimed to evaluate the acute effects of three types of soft drinks sweetened with sucrose and/or NNS on glucose and hormone responses.
METHODS:
We conducted a randomized crossover clinical trial involving 20 adults. Participants ingested 355 mL of carbonated water (CON) and three beverages sweetened with aspartame/acesulfame K (AAK), sucrose/stevia (SUC/STE), and sucrose (SUC), with a 7-day washout period between each trial. Glucose, insulin, glucagon, glucose-dependent insulinotropic peptide (GIP), pancreatic polypeptide (PP), leptin, and ghrelin levels were measured at 0, 30, 60, 90, and 120 minutes, in addition to the area under the curve (AUC).
RESULTS:
The SUC beverage elicited the highest glucose and insulin responses, with significant increases at 30 minutes (P < 0.001). In contrast, SUC/STE resulted in a glucose-lowering effect at 60 minutes (-12.5 mg/dL, P < 0.05) and a sustained increase in PP levels, which peaked at 120 minutes (+73.4 pg/mL, P < 0.05). AAK and CON showed no significant differences in glucose or hormone levels.
CONCLUSION:
This study highlights the differential effects of sucrose- and NNS-sweetened beverages on glucose metabolism and hormonal responses. The glucose-lowering and PP-stimulating effects of SUC/STE suggest potential benefits for glycemic control and satiety. These findings provide insights into the metabolic impact of NNS and their potential role in dietary recommendations for health promotion.
2026-01-01JOURNAL OF HAZARDOUS MATERIALS
The co-transport behavior of polyacrylonitrile microplastics and aniline compounds in porous media
Article
作者: Sun, Huimin ; Yin, Xianqiang ; Li, Xia ; Jiang, Yanji ; Song, Jie
Aniline compounds (ACs) and microplastics (MPs) are emerging contaminants that frequently co-occur in industrial wastewater and soil-groundwater systems. However, their co-transport mechanisms and in particular the role of MPs as carriers to enhance ACs transport remain unclear. This study employs adsorption and column experiments to systematically analyze the adsorption characteristics and mechanisms of polyacrylonitrile microplastics (PANMPs) for aniline and p-chloroaniline. It also examines the effects of key parameters, such as flow rates, pH, and IS, on the transport behavior of ACs in the presence of MPs, thereby offering new insights into their environmental fate. The adsorption experiments revealed that the adsorption of MPs onto ACs follows a multilayer physical adsorption mechanism, with enhanced adsorption capacity observed at lower pH and higher ionic strength (IS). Column transport experiments demonstrated that PANMPs significantly promote ACs migration. Notably, pH and IS modulated the co-transport behavior by altering the adsorption affinity between MPs and ACs, thereby enhancing the disparity in their transport behavior. Furthermore, the greater mobility of PANMPs with increasing flow rates led to a greater extent of ACs transport in the sand column. These findings are of great significance for understanding the transport behavior and fate of MPs and ACs in soil-groundwater.
2025-12-01INTERNATIONAL DENTAL JOURNAL
Control of Viral Aerosol Dispersion During Simulated Dental Procedures
作者: Forero, Manuel ; Allison, James R. ; Calvo, Eliana P. ; Castellanos, Jaime E. ; Holliday, Richard ; Beltrán, Edgar O. ; Martignon, Stefania ; Velandia-Romero, Myriam L. ; Jakubovics, Nicholas S.
AIM:
Although air-cleaning systems (ACS) and high-volume evacuation (HVE) have been shown to reduce dental bioaerosols, few works have looked at viruses. This study aimed to assess the effects of HVE and ACS on dispersion of aerosolised particles and airborne viruses in a simulation model of dental bioaerosols using a detailed and comprehensive sampling approach and different tracer molecules.
METHODS:
MS2 bacteriophage and fluorescein solution were used as viral or dispersion tracers, respectively. These were added independently to the instrument irrigation system and aerosolised during dental procedures. Aerosol mitigation condition groups were ACS, HVE, ACS plus HVE, and No mitigation (control). Aerosols were collected via settlement onto sterile filter papers and agar plates. In addition, a 6-stage Andersen cascade impactor was used for viral air sampling. Fluorescent particles were analysed using ImageJ software, and bacteriophage was quantified using plaque assays and reverse transcription quantitative polymerase chain reaction (RT-qPCR).
RESULTS:
HVE combined with ACS produced the highest reduction in viral spread among the three aerosol-generating procedures (AGPs). This reduction was evident both in the number of fluorescent particles and that of viruses. The effect was more pronounced at the farthest sites. By plaque assay, viral loads in the largest-sized aerosols (>7.0 μm) from air samples were 93% lower in the ACS plus HVE group compared with control, and the load in the smallest aerosols (0.65-1.1 μm) was reduced by 84% (P < .05). By RT-qPCR, the ACS plus HVE group also reduced viral detection in air samples (>80%) more than ACS or HVE alone compared with the control group (P < .05). In ACS or HVE condition, viral RNA was detected even in the absence of infectious virus detected by plaque assay for anterior versus posterior procedures and in the farthest positions.
CONCLUSIONS:
A synergistic effect was obtained in the reduction of aerosolised particles and viruses from surfaces and air samples when HVE was combined with ACS.
CLINICAL RELEVANCE:
Using a comprehensive and depth assessment, this study found that the combination of high-volume evacuation and air-cleaning systems was the most effective measure in mitigating virus dispersion during aerosol-generating dental procedures, translated into lower required waiting (fallow) times between patients' appointments for dental care depending on the type of AGP conducted. The more aerosols are produced during an AGP, the longer it takes to prevent cross-contamination among dental staff and patients. In addition, our findings support the use of HVE, face shields, and well-fitting masks in dental procedures, not only during pandemics but also in everyday practice.
100 项与 磷酸钠倍他米松 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 溃疡性结肠炎 | 日本 | 1992-03-13 | |
| 克罗恩病 | 日本 | 1992-03-13 | |
| 睑缘炎 | 日本 | 1985-11-20 | |
| 结膜炎 | 日本 | 1985-11-20 | |
| 角膜炎 | 日本 | 1985-11-20 | |
| 耳炎 | 日本 | 1985-11-20 | |
| 炎症 | 美国 | 1974-12-31 | |
| 胶原蛋白疾病 | 日本 | 1973-01-31 | |
| 内分泌系统疾病 | 日本 | 1973-01-31 | |
| 心脏衰竭 | 日本 | 1973-01-31 | |
| 肾病综合征 | 日本 | 1973-01-31 | |
| 类风湿关节炎 | 日本 | 1973-01-31 | |
| 眼部炎症 | 日本 | 1964-10-07 | |
| 外耳炎 | 日本 | 1964-10-07 | |
| 中耳炎 | 日本 | 1964-10-07 | |
| 过敏性鼻炎 | 日本 | 1964-10-07 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 139 | (SURF-200 (0.02% Betamethasone Sodium Phosphate in Vehicle)) | 鏇鏇鑰淵範繭觸醖壓顧 = 襯繭製餘顧顧構鬱鹽艱 獵蓋憲醖繭廠襯蓋廠窪 (齋觸選壓積齋製觸糧廠, 顧築鹹鏇鏇淵網醖蓋製 ~ 繭願窪範選繭鏇廠範衊) 更多 | - | 2025-06-04 | ||
(SURF-200 (0.04% Betamethasone Sodium Phosphate in Vehicle)) | 鏇鏇鑰淵範繭觸醖壓顧 = 衊艱顧蓋築壓憲構構艱 獵蓋憲醖繭廠襯蓋廠窪 (齋觸選壓積齋製觸糧廠, 鹽蓋願鏇淵醖膚觸鏇衊 ~ 顧製糧餘廠鏇壓網遞鹹) 更多 | ||||||
临床2期 | 1 | (Bupivacaine Hydrochloride and Betamethasone Sodium Phosphate) | 獵構壓鑰憲獵齋廠窪選(餘遞膚窪壓鏇選選膚窪) = 選憲網鹽糧觸夢構壓憲 鏇網齋齋窪選蓋願構鹹 (衊觸窪製衊製壓艱蓋醖, 顧夢遞憲獵夢鬱網蓋蓋 ~ 遞積築鹽鑰鹹醖願鹹願) 更多 | - | 2020-11-02 | ||
(Bupivacaine Hydrochloride) | 獵構壓鑰憲獵齋廠窪選(餘遞膚窪壓鏇選選膚窪) = 艱構艱遞廠膚蓋構壓衊 鏇網齋齋窪選蓋願構鹹 (衊觸窪製衊製壓艱蓋醖, 醖衊鹹憲範遞網餘範齋 ~ 廠遞憲顧夢齋選齋廠鑰) 更多 |
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