A Phase 3, Randomised, Investigator-blind, Active-controlled, Parallel Group, Multicentre Trial Comparing the Efficacy and Safety of 4-weeks Treatment With LEO 90100 and Daivobet® Ointment in Adult Chinese Subjects With Stable Plaque Psoriasis

This study is conducted to assess the efficacy and safety of LEO 90100 when used on the body for the treatment of stable plaque psoriasis in native adult Chinese subjects, compared to Daivobet® ointment.

开始日期2023-06-21

申办/合作机构

Leo Pharma, Inc.

CTR20223222 / Active, not recruiting临床3期

一项在中国稳定性斑块状银屑病成人受试者中比较LEO 90100和得肤宝 ®软膏治疗4周的有效性和安全性的III期、随机、研究者设盲、活性药物对照、平行分组、多中心试验

主要目的：评价LEO 90100与得肤宝®软膏相比对稳定性斑块状银屑病严重程度和范围的有效性。次要目的：评价LEO 90100与得肤宝®软膏相比治疗稳定性斑块状银屑病的安全性。

开始日期2023-06-21

申办/合作机构

LEO Laboratories Ltd.

[+2]

NCT05811234 / Active, not recruitingN/A

An International, Prospective, Observational Cohort Study to Assess Patient Treatment Satisfaction, Patient-reported Outcomes, Effectiveness, and Safety of a Fixed-dose Combination of Calcipotriene/Betamethasone Dipropionate PAD Cream in the Treatment of Mild-to-moderate Plaque Psoriasis of the Scalp in Adults (PRO-SCALP)

The main aim of this study is to assess treatment satisfaction, quality of life, treatment preference, adherence and convenience, psychosocial effects of scalp psoriasis, sleep quality, and effectiveness, and safety of Calcipotriene/Betamethasone Dipropionate (CAL/BDP) PAD cream in a real-world setting.

开始日期2023-06-13

申办/合作机构

Almirall SA

100 项与倍他米松二丙酸酯/卡泊三醇相关的临床结果

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100 项与倍他米松二丙酸酯/卡泊三醇相关的转化医学

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100 项与倍他米松二丙酸酯/卡泊三醇相关的专利（医药）

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项与倍他米松二丙酸酯/卡泊三醇相关的文献（医药）

2024-03-01·Dermatology and Therapy

Improvements in Plaque Psoriasis Associated with Calcipotriol/Betamethasone Aerosol Foam Treatment: A Post Hoc Analysis of Non-interventional Studies and Clinical Experience

Article

作者: Krogager Eeg, Martin ; Jablonski Bernasconi, Marie Y ; Ratzinger, Gudrun ; Campanati, Anna ; Gerdes, Sascha ; Halioua, Bruno ; Pesiridis, Georgios ; Lazaridou, Elizabeth

INTRODUCTIONPlaque psoriasis is a chronic relapsing inflammatory skin disease that is associated with extensive disease burden that often requires long-term therapy. Treatment of psoriasis with 4 weeks of the aerosol foam formulation of calcipotriol/betamethasone dipropionate (Cal/BD; Enstilar®, LEO Pharma) has been demonstrated to be effective, well tolerated, and associated with high patient satisfaction. Cal/BD foam is approved as a first-line treatment in multiple countries, where several non-interventional studies (NIS) have corroborated the beneficial efficacy and safety profiles determined in the randomized clinical trials. Heterogenicity in these NIS, however, prevents the use of a data pooling strategy for comparisons of effectiveness outcomes across different patient populations.METHODSTherefore, here, we report on a post hoc analysis of effectiveness data consolidated from six prospective NIS to discern any differences in improvement in signs and symptoms of psoriasis attributable to Cal/BD foam treatment across the countries. In addition, we provide real-world experience of clinicians with Cal/BD foam treatment, factoring in changes in usage since these NIS were performed in their local markets.RESULTSThis post hoc analysis of Cal/BD foam NIS brings together data outside of randomized clinical trials from six countries to provide real-world evidence in 1388 patients showing that 4 weeks of Cal/BD foam is an effective and safe treatment option with quick onset of action for patients with psoriasis.CONCLUSIONThese results show that regardless of NIS location, Cal/BD foam remains a well-tolerated, efficacious option for patient care that could be used as a first-line topical therapy for mild-to-severe psoriasis.

2024-01-01·Drugs in context

A narrative review of fixed combination calcipotriol/betamethasone aerosol foam (Enstilar^®) in the management of psoriasis with scalp involvement.

Review

作者: Trüeb, Ralph M ; Mann, Caroline ; Staubach, Petra ; Körber, Andreas ; von Kiedrowski, Ralph

The scalp is the most common site affected in patients with psoriasis with up to 80% of these patients having some degree of scalp involvement. In this narrative review, we evaluate available data on the use of an innovative aerosol foam formulation of calcipotriol plus betamethasone dipropionate (Cal/BD) to treat patients with psoriasis and scalp involvement. The full PubMed database was searched using the terms "calcipotriol", "betamethasone dipropionate" and "aerosol foam", and all articles relating to "psoriasis with scalp involvement" were retrieved and used in the preparation of this review. The evidence supporting the clinical effectiveness, tolerability and impact on health outcomes of Cal/BD aerosol foam in patients with scalp psoriasis was obtained from a phase II clinical trial and real-world evidence data from a non-interventional study as well as from two case series. The findings from these studies show that Cal/BD aerosol foam is rapidly effective, improves skin condition, alleviates symptoms such as itch, and has a positive impact on patient quality of life. These attributes address several unmet needs for patients with psoriasis with scalp involvement and have the potential to improve individual adherence to treatment.

2023-12-31·Journal of Dermatological Treatment

Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics

Article

作者: Zhang, Xiaomei ; Yao, Danni ; Lu, Chuanjian ; Cui, Jingwen ; Yu, Xiaobo ; Deng, Hao ; Ye, Shuyan ; Han, Ling ; Deng, Jingwen ; Yu, Jingjie ; Yan, Yuhong

BACKGROUNDPsoriasis is a chronic skin disease, and topical sequential therapy with a combination of calcipotriol and calcipotriol betamethasone is currently approved topical treatment. However, the exact mechanism by which this treatment regimen relieves psoriasis is unknown.METHODWe assembled a cohort of 65 psoriasis patients and divided post-treatment cohort into responder group and non-responder group according to the Psoriasis Area Severity Index (PASI) score after 12-week treatment. We measured the expression levels of proteins in collected 130 serum samples using our in-depth proteomics platform with a data-independent acquisition mass spectrometer and antibody microarray. We performed bioinformatics analyses of the biologic processes and signaling pathways that were changed in the responder group and constructed a proteomics landscape of psoriasis pathogenesis response to treatment. We then validated the biomarkers of disease severity in an independent cohort of 88 samples using an enzyme-linked immunosorbent assay.RESULTSWe first identified 174 differentially expressed proteins (DEPs) for comparative analysis of proteins between responders and non-responders at baseline (p < 0.05). Then pathway analysis showed that the responders focused more on signaling molecules and interaction, complement and coagulation cascades, whereas the non-responders more on signal transduction and IL-17 signaling pathways. We further identified four candidate biomarkers (COLEC11, C1QA, BNC2, ITIH4) response to treatment. We also found 125 DEPs (p < 0.05) after treatment compared with before treatment in responder group. Pathway analysis showed an enrichment in pathways related to complement and coagulation cascades, phagosome, ECM-receptor interaction, cholesterol metabolism, vitamin digestion and absorption. CD14 was validated as potential biomarkers for the disease severity of psoriasis and treatment targets.CONCLUSIONIn this work, we analyzed the response to topical sequential therapy and finally identified four biomarkers. Additionally, we found that topical sequential therapy may alleviate psoriasis by regulating lipid metabolism and modulating the immune response by affecting the complement activation process.

项与倍他米松二丙酸酯/卡泊三醇相关的新闻（医药）

2024-05-08

·美通社

利奥制药宣布Enstilar®（LEO90100）在中国开展的III期临床试验的Topline结果显示，Enstilar®在患有稳定性斑块状银屑病的中国成人受试者中表现出优效性

Enstilar ® （LEO 90100）在主要终点和双重次要终点中均表现出优于得肤宝 ® （卡泊三醇倍他米松软膏）的优效性，这表明其在降低稳定性斑块状银屑病的严重程度和范围方面具有更好的疗效。总体而言，得肤宝 ® （卡泊三醇倍他米松软膏）和Enstilar ® 均具有良好的耐受性。安全性特征与之前的试验结果一致，并且符合预期，未发现新的安全性问题。该临床试验是利奥制药扩大在中国业务的承诺，通过提供额外的治疗选择为中国银屑病患者带来根本性的改变。 Enstilar ® 是一款以得肤宝 ® （卡泊三醇倍他米松软膏）活性成分为基础的独特的皮肤泡沫制剂，目前是银屑病外用药领域的全球市场领先者。丹麦巴勒鲁普 2024年5月8日 /美通社/ -- 利奥制药作为医学皮肤科的全球领导者，于5月7日宣布了Enstilar ® 在中国稳定性斑块状银屑病成人患者中开展的III期临床试验的积极结果。该临床试验是一项在中国稳定性斑块状银屑病成人受试者中比较Enstilar ® （LEO90100）和得肤宝 ® （卡泊三醇倍他米松软膏）（每日使用一次，为期4周）的有效性和安全性的多中心、随机、研究者设盲、活性药物对照、平行分组的III期临床试验。在中国的39个研究中心共计招募了604名患者。 1 该研究的主要目的是评估Enstilar ® （LEO 90100）相较于得肤宝 ® （卡泊三醇倍他米松软膏）在治疗稳定性斑块状银屑病的有效性。次要目的是评估治疗的安全性。探索性目的包括评估健康相关生活质量。 1 Topline结果表明，Enstilar ® 在主要终点上相较于得肤宝 ® （卡泊三醇倍他米松软膏）表现出优效性。利奥中国总经理殷晓峰表示：" 基于这些令人鼓舞的临床研究成果，我们很期待能够在未来向中国监管当局递交 Enstilar ® 的上市申请。同时，我也非常兴奋，除了利奥中国现有的产品组合外，我们现在有机会为中国患者带来一种新的治疗选择。" 该研究的主要研究者、北京大学人民医院张建中教授表示： "在中国，大约有 700 万银屑病患者 2 。外用药物是银屑病的基本治疗，适合大多数患者。作为本研究的主要研究者，我很高兴看到 Enstilar ® 在中国开展的 III 期临床试验中达到了其主要和次要终点，表现出优于得肤宝 ® 的疗效，且具有良好耐受性的安全性。期待在不久的将来能和同道们分享该项高质量研究的详细数据，希望 Enstilar ® 能尽早用于中国银屑病患者。" 双品牌试验彰显利奥制药在中国的实力 Enstilar ® -- 一种含卡泊三醇/倍他米松的皮肤泡沫剂 -- 是得肤宝 ® （卡泊三醇倍他米松软膏）的改良剂型，得肤宝 ® （卡泊三醇倍他米松软膏）是目前治疗稳定性斑块状银屑病中国成人患者的标准治疗选择之一。 3 该试验提前四个月完成了患者招募，体现了利奥制药在中国日益增长的业务和活动的承诺。利奥制药PSIO全球执行副总裁Becki Morison表示： " 利奥制药在中国的业务发展迎来了振奋人心的进展。我们不仅看到了结果的优效性，还看到了两种组合产品的疗效和良好耐受性。中国是利奥制药的关键市场之一 — 中国的皮肤科领域快速发展，得益于中国团队的出色表现，我们的收入稳步增长。此次试验是利奥制药利用我们深厚的皮肤病学知识来拓展我们在中国的创新和核心产品组合的绝佳例证。" 基于这些结果，利奥制药将着手准备向中国监管当局递交Enstilar ® 的上市申请。 Enstilar ® 中国试验的详细结果将在稍后提交，用于科学报告和出版物。有关Enstilar ® 临床试验（NCT05919082）的更多信息，请访问 clinicaltrials.gov 。 * 本文涉及的 Enstilar ® 尚未在中国获批 " 关于 Enstilar ® Enstilar ® 是一款泡沫制剂气雾剂，含有卡泊三醇一水合物（50mcg/g）和二丙酸倍他米松（0.5mg/g）。在欧盟，其适用于治疗成人寻常型银屑病。使用Enstilar ® 每日一次治疗4周后有治疗响应的患者适合接受长期维持治疗。 3-6 关于银屑病银屑病是一种慢性炎症性皮肤病，经常伴有多种身体和/或心理共病（存在一种或多种其他疾病），例如银屑病关节炎、糖尿病、心血管疾病和抑郁症。 7 参考文献 ClinicalTrials.gov: A Study to Investigate Efficacy and Safety With LEO 90100 Compared With Daivobet® Ointment in Adult Chinese Subjects With Stable Plaque Psoriasis | ClinicalTrials.gov (Accessed May 2024 ) Xiaolan Ding et al. Prevalence of psoriasis in China : A population-based study in six cities. European Journal of dermatology: EJD 22(5):663-7 中国银屑病诊疗指南（2023版） Koo J, et al. Superior efficacy of calcipotriene and betamethasone dipropionate aerosol foam versus ointment in patients with psoriasis vulgaris—A randomized phase II study. Journal of Dermatological Treatment. 2016;27(2):120-127. Leonardi C, et al. Efficacy and Safety of Calcipotriene Plus Betamethasone Dipropionate Aerosol Foam in Patients With Psoriasis Vulgaris—a Randomized Phase III Study (PSO-FAST). J Drugs Dermatol. 2015;14(12):1468-1477. Lebwohl M, et al. Fixed Combination Aerosol Foam Calcipotriene 0.005% (Cal) Plus Betamethasone Dipropionate 0.064% (BD) is More Efficacious than Cal or BD Aerosol Foam Alone for Psoriasis Vulgaris: A Randomized, Double-blind, Multicenter, Three-arm, Phase 2 Study. J Clin Aesthet Dermatol. 2016;9(2):34-41. National Psoriasis Foundation. Comorbidities associatied with psoriatic disease. Available www.psoriasis.org/about-psoriasis/related-conditions . Last accessed May 2024 关于利奥制药利奥制药是一家引领标准治疗，惠及皮肤疾病患者及其家庭和社会的全球公司。利奥制药成立于1908年，大部分股权隶属于LEO基金会，数十年来一直致力于研发，以推动皮肤病科学的发展。如今，利奥制药为不同严重程度的疾病提供了广泛的治疗方案。利奥制药总部位于丹麦，拥有全球员工4300名，为全球数千万患者提供服务。2023年，该公司的净销售额为114亿丹麦克朗。在中国，利奥制药专注于银屑病、特应性皮炎和皮肤感染3大疾病领域，是相关疾病领域的市场领导者，通过有竞争力的产品和服务来提高人们的生活质量。

临床3期临床结果临床成功

2024-04-22

·药渡Daily

华东医药正在悄然称王

又一家药企总营收首次突破400亿元。近日，华东医药发布最新年报，2023年全年，其总营收406.24亿元，同比增长7.71%；净利润28.39亿元，增长13.59%；扣非归母净利润27.37亿元，增长13.55%。其中，医药工业实现销售收入122.17亿元，增长9.45%；净利润23.30亿元，增长9.63%。华东医药发展路径颇有复星医药的影子，但作为同等量级的BigPharma，华东医药在没有新冠业务的羁绊下，表现得更加凶猛，不仅在“减重”领域一路狂飙、在“医美”路上横冲直撞，而且在外延式投资并购方面，更是出手大方，豪掷千金，俨然一副称王称霸的姿态。01津贴热点虽然华东医药十分凶猛，但在战略布局的谋划上，并非鲁莽。站在当下回顾，诸多药企均栽在了新冠相关产品的布局上，投入巨大的新冠项目在“乙类乙管”之后，迅速成为了负资产。但我们看到，近年来紧贴时代发展潮流的华东医药，却在新冠相关布局上十分谨慎。这是谋略上的坚定，亦或仅仅只是迷雾时代的踌躇？真正的原因不得而知，但从华东医药的谋篇布局上，或许可以猜测一二。紧贴时代热点，是近年来华东医药最显著的发展特征。2021年“医美”赛道大爆发，我们看到了华东医药打造了中国最全“医美”布局；GLP-1火热起来以后，正巧落在了华东医药的主打领域，因此我们也看到了中国最全面的GLP-1布局；ADC火爆全球，我们看到了华东医药活跃的身影；自免赛道正在预热，我们又惊喜地发现，华东医药早就置身其中。热点在哪里，哪里就有华东医药活跃的身影。核心业务降糖药的研发方面，华东医药已建立了涵盖口服、注射剂等多种剂型包括长效、单靶点和多靶点全球创新药和生物类似药相结合的6款在研及已上市产品管线。特别是在GLP-1方面，华东医药自主研发的口服小分子GLP-1受体激动剂HDM1002糖尿病适应症已于2023年5月获中美双IND批准；超重或肥胖人群的体重管理适应症的中国IND申请已于2023年9月获得批准。目前该产品已启动II期临床研究。自主研发的GLP-1R/GIPR双靶点长效多肽类激动剂HDM1005用于超重或肥胖人群的体重管理、2型糖尿病2个适应症的中国IND申请已于2024年3月获得批准，正在中国进行Ia期临床。控股子公司道尔生物在研的FGF21R/GCGR/GLP-1R靶点的多重激动剂DR10624已完成中国、新西兰的I期研究，目前正在新西兰开展肥胖合并高甘油三酯血症的Ib/IIa期临床试验。此外，华东医药的利拉鲁肽糖尿病、减重适应症均已获批，德谷胰岛素目前已完成III期临床入组，预计2024年Q4获得主要终点数据。华东医药降糖药领域研发管线来源：年报肿瘤领域研发方面，华东医药建立了涵盖靶向小分子化药、ADC、抗体、PROTAC等超过30项肿瘤创新药产品。从美国ImmunoGen引进的全球首创ADC新药索米妥昔单抗注射液（ELAHERE，研发代码：IMGN853、HDM2002）的中国上市许可申请于2023年10月获得受理，适应症为治疗既往接受过1-3线系统性治疗的叶酸受体α（FRα）阳性的铂类耐药的上皮性卵巢癌、输卵管癌或原发性腹膜癌成年患者。1类新药迈华替尼于2023年5月被纳入突破性治疗品种，用于EGFR罕见突变的晚期非小细胞肺癌。此外，迈华替尼用于EGFR敏感突变的晚期非小细胞肺癌III期临床试验已成功达到主要终点，预计于2024年递交一线EGFR敏感突变的上市申请。首个自主研发ADC项目HDM2005，拟开发用于晚期实体瘤和血液瘤治疗，已于2024年3月递交中国IND申请获受理；首个全自研的HPK-1 PROTAC（造血祖激酶1蛋白降解靶向嵌合体）药物HDM2006已进入IND研究阶段，拟用于晚期实体瘤和血液瘤的单药和联用治疗，预计于2024年底递交IND申请。华东医药肿瘤研发管线来源：年报然而，华东医药最大的收获应该是在自免领域。在这个即将崛起的赛道，华东医药通过注资荃信生物投身其中，填补了自免领域的短板。02自免布局今年3月，荃信生物正式登陆港交所。虽是初登资本市场，但江湖上早有它的传说。在国内专注自免赛道的Biotech并不算多，荃信生物凭借丰富的管线占有着极大的份量。在研管线中包含两个核心产品QX002N及QX005N，以及七个其他候选药物；涉及的靶点包括IL-17A、IL-33、TSLP、IFNAR1等，涵盖了自身免疫和过敏性疾病的四个主要领域，即皮肤、风湿、呼吸道及消化道疾病；适应症包括银屑病、特应性皮炎、系统性红斑狼疮、中重度哮喘等等。华东医药与荃信生物的渊源，可追溯至上世纪90年代。荃信生物创始人为裘霁宛，在1993年毕业后，加入九源基因负责新药研发，而九源基因正是华东医药前董事长李邦良所创建。在九源基因工作11年后，裘霁宛离职创业，并得到华东医药的鼎力相助。在荃信生物2020年的B+轮融资中，华东医药以3.7亿元高调注资，一跃成为荃信生物第二大股东。上市之前，华东医药依然是荃信生物的第二大股东，持续比例高达17.09%。除股权投资外，华东医药还是荃信生物重要的合作伙伴。荃信生物临床进度最快的QX001S的国内商业化权益就被授权给了华东医药，合计从华东医药收取5000万美元付款，以及未来QX001S在国内一半的税前利润。QX001S是首个在中国提交上市申请的国产乌司奴单抗生物类似药，且可能成为首个获批的乌司奴单抗生物类似药。乌司奴单抗于2009年获得美国FDA批准，是针对性抑制IL-23及IL-12路径的首款生物疗法，是治疗银屑病的主要疗法之一。在针对银屑病的III期临床试验中，QX001S显示出与乌司奴单抗相当的临床疗效、安全性、免疫原性及PK特性。QX001S已于2023年7月在中国提交上市申请，预计2024年第四季度获批。荃信生物股权结构中华东医药占比情况来源：荃信生物招股书除了注资荃信生物，华东医药在自免疾病领域已拥有生物药和小分子创新产品10余款。从美国Kiniksa引进的全球创新产品利纳西普（ARCALYST），在国内被列入《临床急需境外新药名单（第一批）》，用于治疗冷吡啉相关的周期性综合征（CAPS）；CAPS适应症的中国上市许可申请于2023年11月获得受理；2024年3月，利纳西普治疗复发性心包炎适应症的中国上市许可申请也获得受理。用于治疗系统性红斑狼疮的创新药HDM3002（PRV-3279）的IND申请已于2023年4月获批，正式加入IIa期MRCT试验（PREVAIL-2）。2023年引入的一系列皮肤疾病适应症的外用制剂，包括从美国Arcutis引进的治疗斑块状银屑病、特应性皮炎、脂溢性皮炎和头皮及身体银屑病Zoryve（罗氟司特乳膏剂和罗氟司特泡沫剂）；从MC2引进的治疗斑块状银屑病Wynzora乳膏，相关的临床注册工作都在积极推进中。华东医药自免在研管线来源：年报03结语在BD方面，华东医药依然延续凶猛的外延式发展策略，引进了一系列十分具有潜质的成熟产品，包括科济药业的泽沃基奥仑赛、罗氟司特乳膏剂、Wynzora乳膏和塞纳帕利等，在医美领域更是横扫市面上各类型肉毒素产品，成为当前中国医美管线最全药企。从华东医药的这一系列布局上，减重、ADC、自免、医美将成为未来华东医药“四驾马车”，特别是在消费医疗方面，目前看来，国内几无对手。后续发展如何，药渡还将持续关注。参考资料华东医药官网、年报、公告等《荃信生物IPO：华东“影子股”，自免“填坑人”》，医曜，2024-03-18

财报抗体药物偶联物临床申请临床1期生物类似药

2024-03-14

·PRNewswire

Psoriasis in America - Insights into Psoriasis Patient Demographics, Quality of Life, Information-seeking Behaviors, HCP Engagement and Treatment Experiences

DUBLIN, March 14, 2024 /PRNewswire/ -- The "Psoriasis in America 2023: Understanding the Psoriasis Patient Experience" report has been added to ResearchAndMarkets.com's offering. Approximately 7.5 million people in the United States have psoriasis. This Psoriasis in America report provides a comprehensive look at life for those living with psoriasis. Using detailed quantitative data, it gives a full picture of the psoriasis patient experience - from symptoms to treatment to HCP relationships to quality of life - so you can make informed, strategic decisions, identify opportunities, and understand potential challenges. The report offers an in-depth look at the psoriasis patient experience. This large-scale, patient-reported data leverages vital quantitative insights essential to understanding key touchpoints in the psoriasis patient journey, including condition management, HCP engagement, quality of life, treatment experience and satisfaction, and much more. This report lifts the curtain on life with psoriasis, giving stakeholders an actionable look at the behaviors, attitudes, perceptions, needs, and experiences of people living with the condition. Data can be used to inform strategic decisions, including product communications, competitive assessments, concept development, landscape analyses, patient journey overlays, and forecasting inputs. This report also addresses important questions that stakeholders may not even know to ask while offering valuable insights into must-have patient-reported data points not available anywhere else. Add-on custom data analysis opportunities are also available for an additional cost - please see the report following purchase for more information. The analyst reaches millions of people through its portfolio of 45+ condition-specific online health communities - including PlaquePsoriasis.com - to provide information, connection, and support to patients and caregivers in the U.S. This report includes a deep-dive into: Psoriasis patient demographics Age, gender, ethnicity, marital status, children, employment status, income, location, insurance, and other health conditions Impact of psoriasis on quality of life Severity, impact on quality of life, symptoms experienced, and what patients wish others better understood Information-seeking behaviors Information sources used, plus topics of interest HCP engagement Primary HCP seen for condition, satisfaction with HCP, and discussion about brands aware of/not used Psoriasis treatment awareness and experiences Aided awareness of specific treatments, treatment experience, satisfaction with current treatments, perceived control with current treatment plan, and interest/participation in clinical trials Key questions answered in this report: To what extent do people say psoriasis impacts their overall quality of life? What's the average number of flares in the past year? What do patients wish others understood about psoriasis? What percentage of patients see a specialist for psoriasis treatment? What treatments have the highest aided brand awareness among patients? What percentage of patients use a biologic? How many patients feel their psoriasis is well-controlled on their current treatment plan? What percentage of patients are likely to switch or add new treatments in the next six months? What medications have patients discussed with their HCP? What are the top online resources people with psoriasis use to find information? What kinds of content and information do patients search for? What percentage of patients search for information on treatment options? Methodology Psoriasis in America consists of: A 20-minute online quantitative survey, covering demographics, comorbidities, quality of life/impact, HCP interactions, as well as treatment awareness, experiences, and discussions Qualitative patient insights from open-ended responses Additional details: Fielded: January 16, 2023 to April 14, 2023 Convenience sample of 490 respondents diagnosed with psoriasis Respondents are age 18+, living in the U.S., and are recruited from proprietary online health communities and recruiting partners Key Topics Covered: Respondent Demographics Research Highlights Condition Status and Quality of Life Severity and Exacerbations Symptoms Experienced Impact on Quality of Life Qualitative Patient Insights Information-Seeking Behaviors Resources Used to Manage Health Types of Content/Information Sought Treatment Awareness and Experiences Primary HCP Seen for Psoriasis Care Aided Brand Awareness of Treatments Treatment Usage Condition Control on Current Treatment and Clinical Trial Interest Treatment Discussions with HCP Appendix with All Data Charts and Distributions Brands and treatments mentioned in this report include: Topical corticosteroid (such as hydrocortisone) BRYHALIT (halobetasol propionate) lotion DesOwen (desonide) SERNIVOT (betamethasone dipropionate) SORILUXT Foam (calcipotriene) TACLONEX (calcipotriene and betamethasone) TAZORAC (tazarotene) VECTICAL (calcitriol) VTAMA (tapinarof) ZITHRANOLT-RR (anthralin) ZORYVET (roflumilast) Acitretin (SORIATANE) ARAVA (leflunomide) Azathioprine (such as IMURAN, AZASAN) Cyclosporine (such as Sandimmune, NEORAL, RESTASIS) Methotrexate (eg, Rheumatrex), also sometimes given as an injection OTEZLA (apremilast) PLAQUENIL (hydroxychloroquine) RINVOQ (upadacitinib) SOTYKTUT (deucravacitinib) Sulfasalazine (Azulfidine) XELJANZ/XELJANZ XR (tofacitinib citrate) AMJEVITAT (adalimumab-atto) Hide until launched in US AVSOLA (infliximab-axxq) CIMZIA (certolizumab) COSENTYX (secukinumab) CYLTEZO (adalimumab-adbm) Hide until launched in US ENBREL (etanercept) ERELZIT (etanercept-szzs) Hide until launched in US HULIO (adalimumab-fkjp) Hide until launched in US HUMIRA (adalimumab) HYRIMOZ (adalimumab-adaz) Hide until launched in US ILUMYAT (tildrakizumab-asmn) INFLECTRA (infliximab-dyyb) IXIFIT (infliximab-qbtx) Hide until launched in US ORENCIA (abatacept) REMICADE (infliximab) RENFLEXIST (infliximab-abda) SIMPONI (golimumab) SIMPONI ARIA (golimumab for infusion) SILIQT (brodalumab) SKYRIZI (risankizumab-rzaa) STELARA (ustekinumab) TALTZ (ixekizumab) TREMFYA (guselkumab) For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

100 项与倍他米松二丙酸酯/卡泊三醇相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	D05AX52	-

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
头皮银屑病	英国	Almirall SA	2021-07-29
银屑病	瑞士	LEO Pharma A/S	2008-09-04
斑块状银屑病	美国	LEO Pharma A/S	2008-05-09
寻常性银屑病	美国	LEO Pharma A/S	2006-01-09

未上市

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
斑块状银屑病	临床3期	中国	LEO Pharma A/S	2023-06-21
斑块状银屑病	临床3期	中国	上海励奥医药咨询有限公司	2023-06-21
斑块状银屑病	临床3期	中国	LEO Laboratories Ltd.	2023-06-21
寻常性银屑病	临床3期	美国	Leo Pharma, Inc.	2010-09-01
光毒性皮炎	临床前	日本	Leo Pharma, Inc.	2010-12-01
银屑病关节炎	临床前	法国	Leo Pharma, Inc.	2009-01-01
头皮皮肤病	药物发现	中国	Leo Pharma, Inc.	2010-09-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05919082 (NEWS) 人工标引	临床3期	斑块状银屑病	604	LEO 90100	繭廠鬱簾糧獵艱憲築鬱(願構膚夢積築襯獵獵觸) = Enstilar®在主要终点上相较于得肤宝®（卡泊三醇倍他米松软膏）表现出优效性衊築選齋築襯鏇糧願壓 (窪遞艱醖製衊鏇製獵衊 ) 达到更多	积极	2024-05-08
NCT05919082 (NEWS) 人工标引	临床3期	斑块状银屑病	604	得肤宝		积极	2024-05-08
NCT03308799 (Biospace) 人工标引	临床3期	皮肤色素沉着	-	Calcipotriene+Betamethasone Dipropionate/Calcipotriene (Patients with skin of color (Fitzpatrick IV-VI))	(憲獵簾選積齋願餘餘鏇) = 壓夢鏇壓願選壓衊鏇獵糧簾積積顧餘鬱齋鬱選 (壓簾簾壓遞鹽醖鏇獵範 ) 更多	积极	2022-09-15
Pubmed 人工标引	N/A	寻常性银屑病	166	Calcipotriene+LEO90100	(襯願範醖壓遞膚廠積膚) = 鹽顧蓋積衊襯憲淵願獵鬱顧廠鹽齋選膚鏇積鹽 (獵衊憲壓餘網淵餘窪鹽, 3.0) 更多	积极	2022-07-18
NCT02668692 (CTgov)	临床3期	寻常性银屑病	213	LEO 80185 gel	廠醖艱選觸淵襯鬱願糧(繭顧壓齋簾顧範構願醖) = 築築膚廠構衊構鏇艱醖蓋糧遞顧觸鏇選鹽糧願 (襯簾醖鏇衊醖遞醖廠齋, 觸廠襯繭餘廠憲遞艱膚 ~ 鏇餘糧顧窪鑰糧壓艱衊) 更多	-	2021-07-27
NCT03819218 (CTgov)	临床2期	寻常性银屑病	7	MC2-01 cream	鑰構構糧糧窪積選窪壓(顧積壓築淵遞積餘膚鹽) = 膚壓淵襯鑰願醖蓋糧製艱選製繭壓壓鬱鑰範範 (觸遞鑰鏇艱壓蓋壓壓窪, 窪艱願艱觸構觸窪蓋淵 ~ 鹹鏇餘齋顧簾膚艱膚衊) 更多	-	2021-02-21
NCT03506477 (CTgov)	临床4期	斑块状银屑病	25	Enstilar® foam (Enstilar® Foam)	願範鹽鏇鬱醖壓餘衊構(鏇鹹獵築遞選糧糧鹽構) = 憲鑰願衊糧願鹹餘鏇廠觸糧鹽鏇網衊觸窪蓋選 (餘構觸願遞蓋壓夢淵鬱, 衊夢夢鏇繭選簾鹹築鏇 ~ 淵憲艱範鏇艱壓醖廠鹹) 更多	-	2021-01-20
NCT03506477 (CTgov)	临床4期	斑块状银屑病	25	Vehicle Foam (Vehicle Foam)	願範鹽鏇鬱醖壓餘衊構(鏇鹹獵築遞選糧糧鹽構) = 鹽夢鹽夢鏇鑰積範餘鹽觸糧鹽鏇網衊觸窪蓋選 (餘構觸願遞蓋壓夢淵鬱, 範襯願鑰願蓋衊網鏇淵 ~ 夢鹹鹽餘鑰願餘壓齋憲) 更多	-	2021-01-20
NCT03806790 (CTgov)	临床3期	寻常性银屑病	182	LEO 90100 foam (LEO 90100 Foam)	壓鹽鬱餘壓範繭顧繭顧(夢襯構範積夢鑰網遞壓) = 蓋製繭蓋醖艱網積鑰夢鏇築網觸齋夢鏇顧觸膚 (願廠餘壓憲選膚淵繭範, 膚選鹹憲願鑰製艱壓憲 ~ 構襯膚鹹衊繭淵築繭觸) 更多	-	2020-12-16
NCT03806790 (CTgov)	临床3期	寻常性银屑病	182	Dovobet® ointment (Dovobet® Ointment)	壓鹽鬱餘壓範繭顧繭顧(夢襯構範積夢鑰網遞壓) = 鏇憲餘遞繭鏇齋鹹鬱選鏇築網觸齋夢鏇顧觸膚 (願廠餘壓憲選膚淵繭範, 窪窪壓顧積網觸蓋積獵 ~ 艱糧範夢廠積餘鬱顧觸) 更多	-	2020-12-16
NCT03802344 (CTgov)	临床3期	寻常性银屑病	498	MC2-01 cream (MC2-01 Cream)	鑰壓鹽醖範遞獵鹹製遞(選餘鑰鑰製齋積壓網鑰) = 獵顧艱獵獵廠醖鏇糧遞網壓製夢鹹遞鹽鹹繭鹽 (艱膚鑰糧糧範築壓積壓, 壓鹹淵夢鬱壓鏇廠夢願 ~ 窪衊鏇鬱觸積製顧簾餘) 更多	-	2020-11-27
NCT03802344 (CTgov)	临床3期	寻常性银屑病	498	Cal/BDP combination (Cal/BDP Combination)	鑰壓鹽醖範遞獵鹹製遞(選餘鑰鑰製齋積壓網鑰) = 衊觸餘獵繭繭衊繭餘範網壓製夢鹹遞鹽鹹繭鹽 (艱膚鑰糧糧範築壓積壓, 衊鏇窪齋窪製範鹹窪糧 ~ 願積觸築網選簾鏇蓋淵) 更多	-	2020-11-27
NCT03848871 (CTgov)	临床4期	斑块状银屑病	20	Enstilar	構齋製淵簾膚廠網獵憲(艱蓋壓鏇餘齋窪觸築觸) = 鏇顧醖範遞鹽顧膚憲襯鹽選窪餘淵齋蓋夢觸衊 (鏇鬱願鹽膚餘膚衊構願, 餘網蓋鏇築艱憲選淵獵 ~ 衊蓋襯築膚選鏇顧憲簾) 更多	-	2020-08-26
NCT03892564 (CTgov)	临床1期	光毒性皮炎 \| 过敏性皮肤反应	35	MC2-01 Cream, irradiation	醖鏇顧積鏇壓艱願醖顧(糧製顧積糧鏇網鹹遞衊) = 憲積製夢鏇壓艱鬱艱齋齋鏇積鬱選醖獵襯鬱願 (壓衊糧襯糧範鹽遞範選, 顧壓繭網淵糧範構醖顧 ~ 膚觸鏇範遞襯餘獵夢構) 更多	-	2020-02-12