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更新于：2026-01-28
Nimustine Hydrochloride
盐酸尼莫司汀
更新于：2026-01-28
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C9H14Cl2N6O2 |
InChIKeyKPMKNHGAPDCYLP-UHFFFAOYSA-N |
CAS号55661-38-6 |
关联
11
项与 盐酸尼莫司汀 相关的临床试验JPRN-jRCT2021190003
Phase II multicenter investigator initiated trial of Convection-enhanced delivery of Nimustine Hydrochloride against brainstem gliomas - Convection-enhanced delivery of Nimustine Hydrochloride against brainstem gliomas
JPRN-jRCTs021180011
Phase II study of Convection-enhanced delivery of Nimustine Hydrochloride combined with systemic Temozolomide against recurrent gliomas at brainstem - ACNU/CED plus systemic TMZ against recurrent gliomas at brainstem: Phase II study
NCT02698280
Phase II Study of Bevacizumab and Nimustine in Patients With Recurrent High Grade Glioma
100 项与 盐酸尼莫司汀 相关的临床结果
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100 项与 盐酸尼莫司汀 相关的转化医学
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100 项与 盐酸尼莫司汀 相关的专利（医药）
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991
项与 盐酸尼莫司汀 相关的文献（医药）2026-02-01JOURNAL OF NEURO-ONCOLOGY
Induction chemotherapy with methotrexate, nimustine, and procarbazine for primary CNS lymphoma in the elderly: a retrospective evaluation of safety and efficacy
Article
作者: Akiyama, Hiroki ; Umezawa, Yoshihiro ; Yoshifuji, Kota ; Yamamoto, Masahide ; Nagao, Toshikage ; Nogami, Ayako ; Mori, Takehiko ; Tanaka, Keisuke
2025-07-15Future Oncology
Effects and safety of TMZ plus RT combined with other drugs in the treatment of glioblastoma: a network meta-analysis
Article
作者: Nie, Jing ; Wang, Simin ; Zhang, Wenfei ; Wu, Jiyong
INTRODUCTION:
Temozolomide combined with radiotherapy has been widely recognized as the first-line treatment for glioblastoma. However, a standard treatment regimen for recurrent glioblastoma after treatment with temozolomide plus radiotherapy is lacking at present. This network meta-analysis aimed to assess and rank the therapeutic efficacy and safety of temozolomide plus radiotherapy combined with 11 other anti-cancer treatments in glioblastoma so as to provide valuable evidence for appropriate clinical decision-making.
METHODS:
Eligible studies investigating the efficacy and safety of temozolomide plus radiotherapy (standard treatment) compared to combination therapies were obtained by searching PubMed, Cochrane Library, and EMBASE. Outcomes included progression-free survival, overall survival, and grade 3-5 adverse events.
RESULTS:
A total of 16 studies were included in this meta-analysis. Except for autologous lymphoid effector cells specific against tumor, galunisertib, and interferon-β, other anti-cancer treatments used in combination with standard treatment resulted in a survival advantage over standard treatment alone. The combination of nimustine with standard treatment performed best in improving overall survival and progression-free survival and exhibited a favorable safety profile, making it the optimal treatment option for recurrent glioblastoma.
CONCLUSION:
After a comprehensive safety analysis, nimustine and lomustine were identified as effective drugs that could be combined with standard treatment.
PROTOCOL REGISTRATION:
www.crd.york.ac.uk/prospero identifier is CRD420251004329.
2025-06-01CANCER SCIENCE
A Multicenter Phase II Trial of Nimustine Hydrochloride Administered via Convection‐Enhanced Delivery in Children With DIPG
Article
作者: Yukihiko Sonoda ; Manabu Kinoshita ; Aya Sato ; Yohei Mineharu ; Yoshiki Arakawa ; Toshihiro Kumabe ; Ichiyo Shibahara ; Kenichiro Matsuda ; Masayuki Kanamori ; Kentaro Chiba ; Yasuo Aihara ; Ryuta Saito ; Teiji Tominaga ; Fumiaki Takahashi
ABSTRACT:
Diffuse intrinsic pontine glioma (DIPG) is a very challenging‐to‐treat pediatric malignant tumor, with a median survival time of < 12 months. Convection‐enhanced delivery (CED) allows for direct drug administration into the tumor site, showing potential as a novel therapeutic approach. This study evaluated the efficacy of CED of nimustine hydrochloride (ACNU) in children with DIPG. This phase 2, single‐arm, multicenter study enrolled patients aged 3–21 years and diagnosed with DIPG. The investigational treatment commenced 1 month after completing radiotherapy (local 50–60 Gy). The treatment involved stereotactic brain surgery for catheter placement, followed by ACNU administration via a CED catheter at a concentration of 0.75 mg/mL for 2–3 days until a cumulative dose of 7 (±0.3) mL was achieved. The primary endpoint was the 1‐year survival rate. From April 2018 to March 2020, 21 children were enrolled in the trial and treated, with 20 evaluable for the primary endpoint. The 1‐year survival rate from the start of radiotherapy was 60%, and the median survival time was 15 months. The response rate was analyzed in 20 patients, with one complete response (CR), six partial responses (PR), nine stable diseases, and four progressive diseases, resulting in a response rate of 35% (CR + PR). The CED of ACNU in the brainstem of children with DIPG after radiotherapy appears to be an effective therapeutic strategy. This approach warrants further development as a treatment for children with DIPG. This study is registered with jRCT (No. jRCT2021190003).
3
项与 盐酸尼莫司汀 相关的新闻（医药）2025-11-11
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上市批准抗体药物偶联物免疫疗法
2025-04-22
·摩熵医药
申请上市抗体药物偶联物临床1期临床申请
2024-02-27
·米内网
上市批准申请上市医药出海核酸药物免疫疗法
100 项与 盐酸尼莫司汀 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 慢性淋巴细胞白血病 | 中国 | 2002-07-25 | |
| 费城染色体阳性慢性粒细胞白血病 | 中国 | 2002-07-25 | |
| 脑癌 | 日本 | 1979-05-22 | |
| 慢性白血病 | 日本 | 1979-05-22 | |
| 结直肠癌 | 日本 | 1979-05-22 | |
| 肝癌 | 日本 | 1979-05-22 | |
| 肺癌 | 日本 | 1979-05-22 | |
| 淋巴瘤 | 日本 | 1979-05-22 | |
| 胃癌 | 日本 | 1979-05-22 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 21 | 願鬱願願範蓋鬱糧蓋築(網鏇鏇醖憲網遞衊夢鹹) = 襯憲醖築顧鏇製獵憲壓 築願齋選積齋願蓋鬱遞 (艱壓艱鹽鹽壓願鑰鹹願 ) 更多 | 积极 | 2022-06-02 | |||
临床1/2期 | 7 | 糧積範艱膚夢遞淵簾糧(淵襯餘窪蓋觸衊鬱網醖) = One in 3 patients who received 0.5 mg/mL developed lacunar infarction 餘範鬱餘廠網繭觸觸壓 (夢夢鹽蓋網顧網簾鏇築 ) | 积极 | 2016-11-07 | |||
临床3期 | 535 | RT/ACNU | 膚襯鹹範製蓋膚鑰廠鹽(鹽獵廠艱壓鏇鬱艱憲壓) = 築艱壓齋鹹鹽鏇憲選糧 願鏇繭鏇鹽鬱蓋積顧衊 (窪艱夢繭鏇醖觸壓鬱憲 ) | 积极 | 2015-11-09 | ||
RT/TMZ | 膚襯鹹範製蓋膚鑰廠鹽(鹽獵廠艱壓鏇鬱艱憲壓) = 觸獵襯廠艱鑰鬱襯齋簾 願鏇繭鏇鹽鬱蓋積顧衊 (窪艱夢繭鏇醖觸壓鬱憲 ) | ||||||
临床1/2期 | - | 築選齋淵蓋獵選繭鹽鹹(顧願壓範鹽鬱衊齋選膚) = Acute toxicity was mainly hematologic and was controllable 簾築衊網鹽顧餘顧網鬱 (築遞齋獵蓋窪蓋淵蓋鬱 ) 更多 | 积极 | 2009-11-01 | |||
N/A | 151 | 鹽廠醖簾壓顧獵鬱壓夢(遞顧鏇鏇網鏇鹽築選鑰) = 壓構餘簾鑰齋選範鹽艱 鹽獵範鏇糧構觸齋淵鹹 (淵衊蓋築顧夢繭淵襯網 ) | 积极 | 2008-05-20 | |||
N/A | 35 | 廠選鑰憲齋築積壓遞鹽(鬱繭襯網鹽廠構艱製廠) = 齋壓衊鬱願壓網膚憲鏇 鏇選衊壓獵夢糧鏇簾範 (蓋獵鏇窪壓鏇遞憲蓋醖 ) 更多 | 积极 | 2008-05-20 |
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