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更新于：2026-02-27
Nimustine Hydrochloride
盐酸尼莫司汀
更新于：2026-02-27
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C9H14Cl2N6O2 |
InChIKeyKPMKNHGAPDCYLP-UHFFFAOYSA-N |
CAS号55661-38-6 |
关联
11
项与 盐酸尼莫司汀 相关的临床试验JPRN-jRCT2021190003
Phase II multicenter investigator initiated trial of Convection-enhanced delivery of Nimustine Hydrochloride against brainstem gliomas - Convection-enhanced delivery of Nimustine Hydrochloride against brainstem gliomas
JPRN-jRCTs021180011
Phase II study of Convection-enhanced delivery of Nimustine Hydrochloride combined with systemic Temozolomide against recurrent gliomas at brainstem - ACNU/CED plus systemic TMZ against recurrent gliomas at brainstem: Phase II study
NCT02698280
Phase II Study of Bevacizumab and Nimustine in Patients With Recurrent High Grade Glioma
100 项与 盐酸尼莫司汀 相关的临床结果
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100 项与 盐酸尼莫司汀 相关的转化医学
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100 项与 盐酸尼莫司汀 相关的专利（医药）
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986
项与 盐酸尼莫司汀 相关的文献（医药）2026-02-01JOURNAL OF NEURO-ONCOLOGY
Induction chemotherapy with methotrexate, nimustine, and procarbazine for primary CNS lymphoma in the elderly: a retrospective evaluation of safety and efficacy
Article
作者: Akiyama, Hiroki ; Umezawa, Yoshihiro ; Yoshifuji, Kota ; Yamamoto, Masahide ; Nagao, Toshikage ; Nogami, Ayako ; Mori, Takehiko ; Tanaka, Keisuke
2025-07-15Future Oncology
Effects and safety of TMZ plus RT combined with other drugs in the treatment of glioblastoma: a network meta-analysis
Article
作者: Nie, Jing ; Wang, Simin ; Zhang, Wenfei ; Wu, Jiyong
INTRODUCTION:
Temozolomide combined with radiotherapy has been widely recognized as the first-line treatment for glioblastoma. However, a standard treatment regimen for recurrent glioblastoma after treatment with temozolomide plus radiotherapy is lacking at present. This network meta-analysis aimed to assess and rank the therapeutic efficacy and safety of temozolomide plus radiotherapy combined with 11 other anti-cancer treatments in glioblastoma so as to provide valuable evidence for appropriate clinical decision-making.
METHODS:
Eligible studies investigating the efficacy and safety of temozolomide plus radiotherapy (standard treatment) compared to combination therapies were obtained by searching PubMed, Cochrane Library, and EMBASE. Outcomes included progression-free survival, overall survival, and grade 3-5 adverse events.
RESULTS:
A total of 16 studies were included in this meta-analysis. Except for autologous lymphoid effector cells specific against tumor, galunisertib, and interferon-β, other anti-cancer treatments used in combination with standard treatment resulted in a survival advantage over standard treatment alone. The combination of nimustine with standard treatment performed best in improving overall survival and progression-free survival and exhibited a favorable safety profile, making it the optimal treatment option for recurrent glioblastoma.
CONCLUSION:
After a comprehensive safety analysis, nimustine and lomustine were identified as effective drugs that could be combined with standard treatment.
PROTOCOL REGISTRATION:
www.crd.york.ac.uk/prospero identifier is CRD420251004329.
2025-06-01CANCER SCIENCE
A Multicenter Phase II Trial of Nimustine Hydrochloride Administered via Convection‐Enhanced Delivery in Children With DIPG
Article
作者: Yukihiko Sonoda ; Manabu Kinoshita ; Aya Sato ; Yohei Mineharu ; Yoshiki Arakawa ; Toshihiro Kumabe ; Ichiyo Shibahara ; Kenichiro Matsuda ; Masayuki Kanamori ; Kentaro Chiba ; Yasuo Aihara ; Ryuta Saito ; Teiji Tominaga ; Fumiaki Takahashi
ABSTRACT:
Diffuse intrinsic pontine glioma (DIPG) is a very challenging‐to‐treat pediatric malignant tumor, with a median survival time of < 12 months. Convection‐enhanced delivery (CED) allows for direct drug administration into the tumor site, showing potential as a novel therapeutic approach. This study evaluated the efficacy of CED of nimustine hydrochloride (ACNU) in children with DIPG. This phase 2, single‐arm, multicenter study enrolled patients aged 3–21 years and diagnosed with DIPG. The investigational treatment commenced 1 month after completing radiotherapy (local 50–60 Gy). The treatment involved stereotactic brain surgery for catheter placement, followed by ACNU administration via a CED catheter at a concentration of 0.75 mg/mL for 2–3 days until a cumulative dose of 7 (±0.3) mL was achieved. The primary endpoint was the 1‐year survival rate. From April 2018 to March 2020, 21 children were enrolled in the trial and treated, with 20 evaluable for the primary endpoint. The 1‐year survival rate from the start of radiotherapy was 60%, and the median survival time was 15 months. The response rate was analyzed in 20 patients, with one complete response (CR), six partial responses (PR), nine stable diseases, and four progressive diseases, resulting in a response rate of 35% (CR + PR). The CED of ACNU in the brainstem of children with DIPG after radiotherapy appears to be an effective therapeutic strategy. This approach warrants further development as a treatment for children with DIPG. This study is registered with jRCT (No. jRCT2021190003).
3
项与 盐酸尼莫司汀 相关的新闻（医药）2025-11-11
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上市批准抗体药物偶联物免疫疗法
2025-04-22
·摩熵医药
申请上市抗体药物偶联物临床1期临床申请
2024-02-27
·米内网
上市批准申请上市医药出海核酸药物免疫疗法
100 项与 盐酸尼莫司汀 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 慢性淋巴细胞白血病 | 中国 | 2002-07-25 | |
| 费城染色体阳性慢性粒细胞白血病 | 中国 | 2002-07-25 | |
| 脑癌 | 日本 | 1979-05-22 | |
| 慢性白血病 | 日本 | 1979-05-22 | |
| 结直肠癌 | 日本 | 1979-05-22 | |
| 肝癌 | 日本 | 1979-05-22 | |
| 肺癌 | 日本 | 1979-05-22 | |
| 淋巴瘤 | 日本 | 1979-05-22 | |
| 胃癌 | 日本 | 1979-05-22 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 21 | 齋範繭築壓製夢築淵網(淵餘鹹觸繭窪鑰膚獵鬱) = 餘餘範積淵網鹹壓醖選 築醖廠壓蓋醖膚遞鏇顧 (構製醖願鬱製壓艱築淵 ) 更多 | 积极 | 2022-06-02 | |||
临床1/2期 | 7 | 觸糧繭廠淵顧鹹醖淵鏇(選繭餘夢憲築餘襯構糧) = One in 3 patients who received 0.5 mg/mL developed lacunar infarction 糧襯鏇簾積觸廠壓窪醖 (簾鏇鬱糧廠醖遞夢膚餘 ) | 积极 | 2016-11-07 | |||
临床3期 | 535 | RT/ACNU | 糧齋鑰選鏇餘衊鹹餘製(簾淵構範獵衊構淵鏇憲) = 繭鹽構願築醖簾觸範淵 壓憲蓋遞積鏇廠繭積壓 (夢範構膚觸醖醖遞淵淵 ) | 积极 | 2015-11-09 | ||
RT/TMZ | 糧齋鑰選鏇餘衊鹹餘製(簾淵構範獵衊構淵鏇憲) = 築鏇繭願鹽壓艱膚壓憲 壓憲蓋遞積鏇廠繭積壓 (夢範構膚觸醖醖遞淵淵 ) | ||||||
临床1/2期 | - | 窪壓構獵獵簾淵膚鑰廠(壓衊鹹廠蓋壓餘構積顧) = Acute toxicity was mainly hematologic and was controllable 製淵構構製蓋艱壓襯鏇 (鏇餘鬱憲鬱醖夢製齋憲 ) 更多 | 积极 | 2009-11-01 | |||
N/A | 151 | 窪蓋範艱夢範製構遞夢(壓蓋壓壓遞醖夢鹹膚獵) = 範顧構襯壓蓋鬱遞鬱鏇 築製範網艱衊願範蓋鹽 (構範廠廠顧繭壓廠鬱襯 ) | 积极 | 2008-05-20 | |||
N/A | 35 | 願簾積鏇淵窪鏇選鬱艱(憲鹹鬱繭簾繭蓋餘憲繭) = 繭窪淵鬱鬱餘鹹積願廠 選構醖憲網鏇鹽願遞壓 (構網築鏇獵廠鬱衊壓夢 ) 更多 | 积极 | 2008-05-20 |
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