Chicken meat contains higher percentage of polyunsaturated fatty acids that are susceptible to oxidative deterioration ultimately leading towards lower consumer acceptability for chicken meat products. Accordingly, meat processing industries are looking for combinations of natural antioxidants to enhance the oxidative stability and consumer acceptability of meat based products. The present study aimed to investigate the influence of directly added quercetin dihydrate in combination with α-tocopherol on oxidative stability, color characteristics, total carbonyls and flavor volatile compounds in chicken meat patties.

METHODS:

Considering the preliminary studies, 3 levels of quercetin dihdrate @ 25, 50 and 100 mg/kg meat in combination with α-tocopherol at the rate 100 and 200 mg/kg meat were added to develop chicken meat patties and were stored at refrigeration temperature for 7 days. The oxidative stability of the antioxidant treated patties was determined by measuring malonaldehydes using TBARS and total carbonyls assay. The color (Lightness, redness and yellowness) of the patties was determined by using Konica Minolta Color Meter. Moreover, the volatile compounds were measured through gas chromatography at various storage intervals.

RESULTS:

The results elucidated that quercetin dehydrate inclusion at the rate of 50 mg/kg meat as well as particularly 100 mg/kg meat decreased the oxidation by reducing generation of malonaldehydes and total carbonyls in treated patties. Highest value for TBARS at initiation of storage was reported in (T₀) as 1.93 ± 0.02 whereas lowest were reported in T₆ and T₅ as 0.37 ± 0.01 and 0.38 ± 0.03 that were increased to 3.47 ± 0.14, 0.90 ± 0.05 and 0.94 ± 0.34 at the completion of storage. Moreover, the lowest carbonyls also reported in T6 and the values at various storage intervals (1st, 3rd and 7th) were as 0.59 ± 0.025, 0.77 ± 0.015 and 1.02 ± 0.031, respectively. The antioxidants inclusion also inhibited volatile flavoring compounds particularly aldehydes like hexanal and pentanal in a dose dependent manner (p ≤ 0.05). Lowest hexanal values reported in T₆ as 2488 ± 103 followed by T₄ (3701 ± 111) at the start of the trial whereas highest in T₀ (control) as 54,768 ± 431 that were increased to 9569 ± 607, 112,550 ± 897 and 359,826 ± 1285, correspondingly. The hexanal, as a critical indicator for the determination of volatiles in meat based products, was decreased with the addition of antioxidants and its highest values were reported in control group.

CONCLUSIONS:

Quercetin dihydrate addition along with alpha tocopherol is a pragmatic choice to improve oxidative storability and volatile flavor compounds in cooked meat patties. The data obtained will help meat processor to better develop antioxidant enriched formulations to augment oxidative stability and quality of processed meat products.

Frontiers in Veterinary Science

Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics

Article

作者: Tamura, Norihisa ; Takahashi, Yuji ; Toutain, Pierre-Louis ; Ohta, Minoru ; Kinman, Christopher Ken ; Ishikawa, Hiroshi ; Inoue, Kaori ; Nukada, Toshio ; Kuroda, Taisuke ; Mita, Hiroshi ; Ebisuda, Yusaku ; Minamijima, Yohei

Introduction:

Quinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects. The purpose of this study was to analyze the variability in plasma quinidine concentrations using population pharmacokinetics to determine an effective and safe dosage regimen for Thoroughbred horses.

Methods:

Six healthy Thoroughbred horses were treated with 20 mg/kg quinidine sulfate dihydrate (16.58 mg/kg QND base) administered PO or 5 mg/kg quinidine hydrochloride monohydrate (4.28 mg/kg QND base) administered IV (single administration), and blood samples were taken regularly. Four healthy horses were treated with 20 mg/kg quinidine sulfate dihydrate administered twice (every 6 h) via PO route. For the other 19 Thoroughbred racehorses that developed AF, blood samples were taken during quinidine therapy. Quinidine concentrations were measured in all plasma samples using liquid chromatography with tandem mass spectrometry, and the data from 29 horses were modeled using a nonlinear mixed-effects model, followed by Monte Carlo simulations (MCS).

Results:

The median quinidine concentration for successful sinus rhythm conversion was 2.0 μg/mL (range: 0.5–2.7 μg/mL) in AF horses, while a median concentration of 3.8 μg/mL (range: 1.6–5.1 μg/mL) showed adverse effects. MCS predicted that plasma quinidine concentrations for quinidine sulfate dihydrate PO administration (loading dose: 30 mg/kg, maintenance dose: 6.5 mg/kg q 2 h) reached 1.4, 2.0 and 2.7 μg/mL in 90, 50 and 10% of the horse populations, respectively. Increasing the loading dose to 45 mg/kg and the maintenance dose to 9 mg/kg q 2 h, the plasma concentrations achieved were 1.9, 2.8, and 3.8 μg/mL in 90, 50, and 10% of horse populations, respectively.

Discussion:

Using simulations, different empirical dosing regimens were proposed to achieve plasma quinidine concentrations immediately or progressively, representing a tradeoff between optimizing therapeutic effects and minimizing adverse effects. A combination of these dosing regimens is recommended to gradually increase the therapeutic concentration levels of quinidine for safe and effective treatment of AF in racehorses.

项与 Quercetin Dihydrate 相关的新闻（医药）

2021-03-07

·GlobeNewswire

Keravita Pro Reviews (Supplement)- Does Keravita Pro Really Effective For Nail Fungus? Review By DietCare Reviews

New York City, NY , March 07, 2021 (GLOBE NEWSWIRE) -- Keravita Pro Reviews: Groundbreaking New Report Gives Important Information Every Consumer Needs To Know. MUST SEE: Urgent Keravita Pro Report – “You Will Not Believe What We Found!” Good looking and nourished nails and hair are always a sign of proper health. However, to enjoy these characteristics on their hair and nails, one needs to learn how to enrich them. After all, they don’t only ensure one is healthy, they help to leave one with a clean and neat look too. Many people are always on the search for the best solution to improve their hair and nail health – whether it’s through creams, ointments, diets, and even procedures. In many cases, the success of these methods is always minuscule to near nothing. Well, there may just be a new solution available in the market. According to the official website Keravita pro reviews, the KeraVita Pro supplement is formulated to aid in the support of good hair and nails – ensuring they are neat, enriched, and healthy. In some cases, unhealthy nails and hair can even lead to fungal infections. Fungal infections can be unsanitary and ultimately, cause itchiness, irritation, and odors – they can be quite embarrassing for people. Yet, irritation and intense odors are not all one has to think of when suffering from fungal infections. If not properly treated, the infections may even lead to organ failure. The makers of the KeraVita Pro supplement go on to claim that the supplement helps to tackle these infections. Unlike other supplements, the supplement eliminates fungal infections, enriches the nails and hair with the right nutrients, and ensures long term effects – without the risks of rebounds. So, before one invests in the supplements, it is worth learning more about what it is and what it does so they can make full use of it. The KeraVita Pro reviews below helps to breakdown and outline all there is to know about the supplement. Learn more about the science behind the KeraVita Pro ingredients: Visit Official site keravitapro101.com What is the KeraVita Pro Supplement? The KeraVita Pro supplement is formulated to support good hair and nail health. Furthermore, the formula helps to treat infections of the nails and scalp to give them long lasting results with no risks of rebounds. In addition to working on the nails and hair, the formula aids in improving skin health, promoting circulation, and supporting the immune system to prevent further infections. The official supplement site claims that it is formulated using 100% safe and natural ingredients and doesn’t contain substances, fillers, toxic chemicals, and synthetics in its formulation. However, before using the KeraVita Pro supplement, one must learn strategies to effectively help support the nails, hair, and overall health. Pairing the strategies with the supplement helps to optimize the results. How Does the KeraVita Pro Supplement Work? The KeraVita Pro supplement is formulated using a selection of ingredients to ensure optimal results. Each ingredient is added for its function which ultimately contributes to the overall functions of the supplement. The KeraVita Pro supplement is designed to work in nine key steps. These include the fast penetration stage, massive fungus build up extermination, blood purification stage, dry skin reconstruction, hands, feet, nail rejuvenation, anti-fungal defense army, anti-fungal lung shield activator, double up the anti-fungal defense, and ultimate toxic fungus cleanse up. Fast Penetration Stage When one takes the supplement, the body ingredients begin to work on the body in what is known to be the fast penetration stage. Massive Fungus Build Up Extermination The massive fungus build up extermination stage is when the supplement cleans the arteries and veins from a fungal and other pathogen build up over the past years – up to 60 years. Blood Purification Stage The blood purification stage helps to dissolve fungal matter flowing in the blood for years. Dry Skin Reconstruction In this stage, several ingredients in the supplement help to repair the skin to its former elasticity and firmness. Hands, Feet, and Nail Rejuvenation The KeraVita Pro supplement helps to strengthen the nails and target infection – which is visible and has plagued the body for years. Anti-Fungal Defense Army In this stage, the body begins to synthesize more antibodies to attack any of the remaining fungi and fungal spores. Anti-Fungal Lung Shield Activator During this stage, the supplement works on the lungs. Around the lungs where blood and air meet, the supplement works to strengthen and fortify this area. Double Up the Anti-Fungal Defense During the double up of the anti-fungal defense stage, the body is further fortified and helps to provide a stronger immune system. Ultimate Toxic Fungus Cleanse Up This last stage allows the body to be cleansed further and flushes out toxins through urinating and sweating. Ultimately, the KeraVita Pro supplement helps improve scalp and hair health whilst fixing distorted toe shapes, brittle, crumbled, and raged ski, whitish to yellow-brown discoloration, and bleeding or discoloration of the skin.. Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station Reference: Effect of air-conditioner on fungal contamination Reference: KeraVita Pro Supplement Ingredients The KeraVita Pro supplement combines up to 31 active ingredients. As mentioned above, each ingredient is carefully picked for its functions. The ingredients include; Soursop Leaves - Soursop is responsible for treating countless parasitic infections, hypertension, and other stomach ailments. Furthermore, soursop leaves are packed with antioxidants – flushing free radicals and toxins from the body. Curcumin - Curcumin, a yellow colored compound is packed with anti-inflammatory properties. Furthermore, Curcumin helps to treat depression and liver disease whilst lowering bad cholesterol. Rhubarb - Rhubarb is an excellent compound for treating digestive problems. It aids in treating constipation, diarrhea, and heartburn. Generally, it supports the digestive system's health. Burdock - Burdock helps with urinary health and improves immune health. Furthermore, the herb helps to purify the blood and treats a selection of infections including skin related conditions. Sheep Sorrel - Sheep sorrel is particularly added to treat inflammation and diarrhea. Slipper Elm - Slipper Elm treats a wised variety of ailments. Amongst the conditions, it helps to treat include sore throat, diarrhea, digestive, bowel, and urinary infections. Lycopene - Found primarily in tomatoes, Lycopene is a powerful antioxidant. Additionally, it improves heart health, lowers blood pressure, lowers blood sugar levels, prevents asthma attacks, and reduces the risks of cancer Vitamin E - Vitamin E eliminates nail fungus whilst repairing and regenerating the cells – allowing the nails and hair to grow and maintain health. Vitamin E and Skin Health See The Overview Article Reference: Vitamin C - Vitamin C is known to boost the immune system and reducing the chances of getting sick. Selenium - Selenium promotes metabolism and protects the body against stress. Additionally, it boosts immunity, lowers mental decline, aging, and heart disease. Graviola Leaf - Graviola leaf is added to the supplement for its impressive anti-fungal and anti-bacterial properties. It helps to treat infections caused by fungi, bacteria, and other parasites. Red Raspberry - Red raspberry protects against diseases like diabetes, cancer, and anti-aging effects. Green Tea Leaf - The green tea leaf contains healthy bioactive compounds that help to further fortify the body’s defenses. Beta-glucan - Beta-glucan helps to naturally stimulate the immune system and improves skin conditions. Turmeric - Turmeric is packed with powerful antioxidant, anti-inflammatory, and other medicinal properties thanks to its bioactive compounds. Pine Bark - As an antioxidant, pine bark helps to reverse the effects of oxidative stress on the cells. Additionally, the natural root protects the skin from damage from the sun. Essiac Tea Complex - Similar to pine bark, the essiac tea complex boasts antioxidant properties. Grapeseed - Grapeseed eliminates the risks of infectious disease. The Mushroom Complex - Mushroom complex on the other end helps to improve one’s immune system. The Mushroom complex contains three key mushroom blends – Shiitake, Reishi, and Maitake. Shiitake mushrooms help to boost the overall immune system and treats a heap of diseases. Reishi mushrooms boost immunity similar to shiitake mushrooms. Additionally, it helps to energize the body whilst eliminating stress and improving sleep. Related to the two other mushrooms, Maitake is added to complement them whilst acting as a carcinogen. Quercetin Dihydrate - Quercetin dihydrate provides anti-allergy properties. Reference quercetin dehydrate article Pomegranate - Pomegranate is packed with all the essential minerals and nutrients. Olive Leaf - Olive leaf is powered with antioxidant properties while boosting the immune system. Arabinogalactan - Arabinogalactan is added to aid in strengthening and boosting the immune system. Cat’s Claw - Cat’s claw helps to prevent viral and fungal infections. Garlic - Garlic has anti-inflammatory, antioxidant, and medicinal properties. It is highly nutritious too. Panax Ginseng - Panax ginseng is known to boost the immune system and provides anti-inflammatory and antioxidant properties. It is responsible for energizing the body and fighting tiredness too. Furthermore, Panax ginseng improves brain function, reduces cancer risks, and lowers blood sugar. Learn more about the science behind the KeraVita Pro Supplement ingredients KeraVita Pro Supplement Dosage According to the official site Keravita Pro reviews, one should take two capsules of the supplement with a glass of water - this daily recommended dosage. It is recommended that one takes the supplement after their first meal of the day to experience maximum results throughout the day. Furthermore, one should take the KeraVita Pro supplement daily without skipping days to ensure it works and garners optimum results. Whilst the supplement is 100% safe and natural with no risks of negative effects according to the official site, it is still not recommended to take more than the recommended dosage. After all, taking the supplement more than the recommended dose doesn’t ensure expedited results rather; it may even further aggravate one’s problems. Nonetheless, one should remember that the supplement is not a magic pill – it doesn’t provide magical effects! Thus, one should be patient when using it and allow enough time to garner results. According to its manufacturer, the KeraVita Pro supplement works in 3 weeks. However, the actual duration varies from person to person due to different factors. Depending on their age, gender, chemical makeup, and even the severity of their infection, one will experience results at different times. So, it is not a surprise that one may experiences results in three weeks. Yet, others may experience the results in more than 3 weeks. One thing that is constant is that in two to three months, one will begin to notice changes in their nails and hair health and growth. There is no exact duration that one should take the supplement – it all depends on how it works for them and their needs. However, according to the official site, one should take the supplement for at least 3 to 6 months to ensure optimal results. Along with the supplements, one wants to maintain the key strategies to maintain nail and scalp health. The KeraVita Pro supplement is formulated to work for anyone. However, it has restrictions too. The supplement is not recommended for people who suffer from diabetes or other medical ailments. Additionally, pregnant women, women who breastfeed, and people under the age of 18 years are recommended against using the supplement. Read Real Customer Benefits, Ingredients, Price, Website, Manufacturer, Side Effects & Complaints Before You Try!!? Find out here KeraVita Pro Supplement Benefits According to the KeraVita Pro reviews, the supplement comes with a plethora of benefits for the body. The supplement does a great job at supporting the nails and hair. However, this is not all that the supplement does. It provides a variety of more benefits for the rest of the body. The key functions of the KeraVita Pro supplement include; Formulated from 100% safe and natural ingredients Packed with minerals, vitamins, and other nutrients Eliminates toenail and scalp fungal infections – preventing rebounds Detoxifies the body – flushing out toxins and bacteria from the body Boasts anti-inflammatory and antioxidant properties Lowers blood sugar levels and promotes healthy blood sugar Regulates LDL and HDL levels Improves skin health Fortifying the immune system Boosts digestion Energizes the body Keravita Pro reviews also shows improves cardiac and skeletal health Gives one confidence and increases their self-esteem KeraVita Pro Supplement Pricing The KeraVita Pro supplement is available for purchase on the official website. The supplement comes in a choice of three different pricing packages. The basic one comes with a single 60 capsule bottle that lasts for 30 days and costs $69 instead of $99 along with free shipping. One can opt for three bottle package which is the most popular package with customers according to the site too. This popular package costs $59 per bottle with free shipping. Thus, instead of $297, one will pay a total of $177. However, for the best value, one can opt for the six-bottle package. This package costs $49 per bottle and a total cost of $294 instead of $594 – allowing them to save up to $300. Therefore, to enjoy the best discount, one is recommended to go for more bottles. There may be a concern that the supplements may go bad if they are bought in a large batch – this shouldn’t be a problem. After all, each bottle shipped out comes with a shelf life of two years. Thus, even investing in the 6 bottle package will only have the supplement last for 6 months. In addition to the discounted prices, the KeraVita Pro supplement comes with a risk-free 100% 60-day money back guarantee. With the 60-day risk-free use, one can test and use the supplement for up to 2 months after purchase. If they are not impressed with the results, they can ask for a full refund with no questions asked. According to the site, the KeraVita Pro supplement is available for purchase on the official site. Thus, one will not find them stocked in local stores or marketplaces like Amazon or Walmart. This is done to prevent the customer from falling victim to scammers and duplicators. On the site, one can use different payment methods like debit cards, credit cards, or PayPal. The site’s gateway is protected with an SSL certificate and encryption to ensure the customer’s information is protected at all times like it is claimed by the site. Check 2021 Current KeraVita Pro Supplement pricing KeraVita Pro Reviews - Final Verdict Overall Keravita Pro supplement reviews conclusion, the KeraVita Pro is a unique supplement unlike other supplements designed to support nail and hair health. Keravita Pro reviews show this formula helps to treat fungal infections and ultimately, providing long lasting results – without any rebounds. Nevertheless, according to the official site, the KeraVita Pro supplement doesn’t more than just focusing on the nails and hair. The supplement impacts other areas of the body too. This includes boosting overall health, improving heart and liver health. Furthermore, the supplement boasts powerful antioxidant, anti-inflammatory, and medicinal properties. After all, the KeraVita Pro supplement comes with a risk-free 100% 60-day money back guarantee. So, if one is not impressed, they can always be refunded their full purchasing costs. Nevertheless, one should keep in mind that the KeraVita Pro is a dietary supplement. Thus, they should never replace it with their prescribed medication or treatment plan. In fact, one is advised to consult their physician to get an ok to use the supplement – even if it is not a prescription medication! As mentioned above, people with existing conditions, pregnant women, breastfeeding women, and individuals under the age of 8 years old are advised against using the KeraVita Pro supplement. >>Visit KeraVita Pro Official Site To Get Huge Discount Media Contact: contact@keravitapro101.com | By Phone: United States, Australia, UK & Canada 1-800-390-6035 About: DietCare Reviews DietCare Reviews shares e-commerce and sales news, product reviews and latest news on various products. This review for informational purposes only. The information does not constitute advice or an offer to buy. Any purchase done from this story is done on your own risk. Consult an expert advisor / health professional before any such purchase. Any purchase done from this link is subject to final terms and conditions of the website that is selling the product. The content on this release does not take any responsibility directly or indirectly. 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100 项与 Quercetin Dihydrate 相关的药物交易

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