Bupropion Hydrochloride/Naltrexone Hydrochloride

全球肥胖人群已突破 13 亿大关，这一庞大群体不仅面临体重困扰，更承受着代谢性疾病、心血管疾病乃至癌症等慢性健康问题的威胁，给各国医疗系统带来了沉重的负担。在此背景下，市场对新型高效肥胖治疗方案的需求日益迫切。 曾经专为 2 型糖尿病开发的 GLP-1 受体激动剂，凭借其显著的减重效果，彻底颠覆了传统肥胖治疗格局，掀起了新一轮的投资与研发热潮。如今，肥胖治疗的研究焦点已不再局限于单纯降低体重，而是向着追求持久的代谢改善与心血管保护等综合健康获益迈进。近日，《Nature Reviews Drug Discovery》杂志发表专题分析，深度剖析了肥胖药物领域快速演变的市场态势。一、当前肥胖治疗方案：从传统疗法困境到 GLP-1 类药物崛起（一）传统治疗方案的局限与挑战 生活方式干预作为肥胖管理的基础手段，单独实施时往往难以达到理想效果。减肥手术虽能实现最为显著的减重成效，但因其侵入性特点，仅适用于重度肥胖患者，难以普及。在药物治疗领域，早期疗法更是屡遭挫折，受限于疗效有限、安全性质疑及医保覆盖不足等问题。 早期肥胖药物多作用于中枢神经系统，例如去甲肾上腺能厌食剂苯丁胺、其与抗惊厥药托吡酯的复方制剂，以及抗抑郁药安非他酮与阿片拮抗剂纳曲酮的复方制剂等。这类药物减重效果中等，且因广泛作用于中枢神经，常伴随神经精神类副作用。另一类药物奥利司他则通过抑制膳食脂肪吸收发挥作用，虽安全性相对较高，但疗效有限且胃肠道耐受性较差。总体而言，这些传统疗法未能有效拓展市场规模，区域市场呈现分散状态。 更严重的是，多款肥胖药物因安全问题接连退市：利莫那班因可能增加自杀风险、西布曲明和芬氟拉明因存在心血管风险、氯卡色林因潜在致癌风险，这些事件严重打击了市场对肥胖药物的信心，让行业发展蒙上阴影。（二）GLP-1 类药物重塑治疗格局 GLP-1 受体激动剂的问世彻底扭转了肥胖药物市场的颓势。这类药物通过模拟调节食欲和能量代谢的肠道激素，实现了精准靶向作用，在心血管安全性和神经精神安全性方面展现出明显优势。 2014 年，利拉鲁肽获批肥胖适应症，成为肥胖治疗领域的关键转折点。此后，司美格鲁肽和替尔泊肽凭借更优的疗效和每周一次的给药便利性，在与利拉鲁肽价格相近的情况下，迅速抢占市场，推动肥胖药物销售额大幅增长。 司美格鲁肽于 2021 年在美国获批，可实现平均约 15% 的体重降低。它不仅是首个经 SELECT 试验证实具有心血管获益的减肥药，更是首个获批用于代谢功能障碍相关脂肪性肝炎治疗的 GLP-1 受体激动剂。这些突破性数据推动肥胖药物实现 “去肥胖化” 转型 —— 从单纯的形象管理工具，转变为能够挽救生命、保护器官的严肃治疗手段，有效化解了支付方的顾虑与社会对肥胖治疗的偏见。 替尔泊肽作为一种 GIP/GLP-1 双受体激动剂，疗效更上一层楼，平均减重幅度可达 20%，且耐受性良好。SURMOUNT-5 头对头试验已证实其疗效优于司美格鲁肽。除减重作用外，该药在肥胖合并心力衰竭或阻塞性睡眠呼吸暂停的患者中也显示出显著临床获益。目前，针对替尔泊肽治疗骨关节炎、慢性肾病、MASH、1 型糖尿病及心血管疾病效果的多项临床试验正在推进，未来有望凭借更广泛的适应症获得更有利的医保支付地位。二、现有主流药物的局限与新一代疗法的研发方向（一）主流 GLP-1 类药物的短板 尽管司美格鲁肽和替尔泊肽取得了巨大进步，但在临床应用中，其局限性也逐渐显现：减重效果会进入平台期，部分患者对药物应答不佳，且停药后体重易反弹。对于严重肥胖患者而言，15%-20% 的减重幅度可能仍无法满足治疗需求。 同时，业界开始关注减重 “质量” 问题。现有药物主要通过抑制食欲发挥作用，并未直接靶向脂肪组织、增加能量消耗或保护肌肉。快速减重过程中，总减重量的 15%-40% 可能来自肌肉流失，这对老年人或肌肉减少性肥胖患者尤为不利。此外，若缺乏配套的生活方式干预和长期监测，这种不健康的减重模式也令人担忧。（二）新一代肥胖疗法的研发策略与在研管线 这些挑战正驱动着新一代肥胖疗法的研发，新型疗法凭借新颖的作用机制和优化的药理学特性，旨在对现有 GLP-1 疗法进行补充和升级。 药物名称作用机制研发企业研发阶段CagriSemaGLP-1/胰淀素双激动剂诺和诺德III 期AmycretinGLP-1/胰淀素双激动剂诺和诺德II 期AZD6234胰淀素类似物阿斯利康II 期Petrelintide胰淀素类似物Zealand Pharma / 罗氏II 期MariTideGLP-1 受体激动剂/ GIP 拮抗剂安进III 期CT-388GLP-1/GIP 双激动剂罗氏II 期RetatrutideGLP-1/GIP/鸟苷酸环化酶 - C 三重激动剂礼来III 期SurvodutideGLP-1/胰高血糖素双激动剂勃林格殷格翰III 期AZD9550GLP-1/胰高血糖素双激动剂阿斯利康II 期PemvidutideGLP-1/胰高血糖素双激动剂AltimmuneII 期VK2735GLP-1/GIP 双激动剂Viking TherapeuticsIII 期口服司美格鲁肽GLP-1 受体激动剂诺和诺德预注册OrforglipronGLP-1 受体激动剂礼来III 期TERN-601GLP-1 受体激动剂Terns PharmaceuticalsII 期METO97GLP-1 受体激动剂MetseraII 期Trevogrumab生长分化因子 8 / 肌肉生长抑制素抑制剂再生元II 期BimagrumabII 型激活素受体阻滞剂礼来II 期Garetosmab激活素 A 抑制剂再生元II 期 下一代疗法的研发主要围绕五大核心策略展开： 多靶点激动剂研发：将 GLP-1 与胰高血糖素类似物结合，开发三重 / 双重激动剂（如 Retatrutide、Survodutide、Pemvidutide），在抑制食欲的基础上，进一步增加能量消耗、减少内脏脂肪，力求超越单一 GLP-1 受体激动剂的疗效。 胰淀素与 GIP 通路探索：聚焦胰淀素类似物和 GIP 调节剂（如 CagriSema、MariTide、Amycretin 等），尤其当与 GLP-1 联用时，有望更强效地抑制食欲并改善血糖稳态。 偏向性 GLP-1 激动剂开发：这类药物能选择性激活 cAMP 信号通路，同时限制 β- 抑制蛋白介导的受体脱敏，具备更强效、持久的疗效和更佳的胃肠道耐受性潜力。 肌肉保护策略落地：开发肌肉生长抑制素和激活素 / TGF-β 通路抑制剂，在 GLP-1 类药物带来快速减重的同时，靶向肌肉生长的关键负调控因子，保护瘦体重（肌肉），优化体成分，这对老年人等脆弱人群的长期健康至关重要。 依从性优化升级：一方面通过新机制改善恶心、呕吐等胃肠道副作用；另一方面，着力提升给药便利性，除现有每周注射剂型外，研发每两周或每月一次的长效注射剂及口服小分子药物，减轻患者治疗负担，助力长期坚持治疗。三、市场展望：规模激增与格局重构并存（一）市场规模预测 据预测，全球七大主要市场（美国、法国、德国、意大利、西班牙、英国和日本）的肥胖药物销售额将从 2023 年的 55 亿美元大幅增长至 2033 年的 570 亿美元，年复合增长率高达 26%。增长的核心驱动力来自高效药物的持续迭代、治疗率的不断提升以及市场准入的逐步扩大。不过，高昂的药价与庞大的适用人群，使得在现有模式下实现全民治疗在经济上尚不具备可行性。 图1. 主要市场肥胖药物销售额预估（传统药物包括：奥利司他、Contrave/Mysimba、Qsymia以及去甲肾上腺能厌食剂）（二）2033 年市场格局研判 预计到 2033 年，将有 5 款新疗法成功上市，分别是口服司美格鲁肽和 CagriSema（诺和诺德）、Orforglipron 和 Retatrutide（礼来）以及 Survodutide（勃林格殷格翰）。尽管 GLP-1 单激动剂仍将是市场增长的重要动力，但以替尔泊肽、CagriSema、Retatrutide 和 Survodutide 为代表的多受体激动剂预计将主导市场，贡献 2033 年总预计销售额的近 440 亿美元，占比达 77%。 具体产品市场表现预测如下： Wegovy（司美格鲁肽注射剂）：2024 年将保持销售领先地位，但随着竞品陆续上市，市场份额将逐步下降；2031-2032 年主要市场仿制药的上市有望缓和这一下滑趋势。 替尔泊肽：凭借卓越的减重疗效和在多种合并症中的积极临床数据，预计将成为并长期维持销售额和患者份额的领导者。 CagriSema：基于司美格鲁肽的成熟市场基础，有望被视为升级版疗法，持续推动诺和诺德在肥胖药物市场的增长。 Survodutide：由于胃肠道耐受性预期较低，且医生对胰高血糖素类似物相对不熟悉，市场接纳速度可能较慢；但如果其在 MASH 领域的开发项目取得成功，将成为合并 MASH 的肥胖患者的优选治疗方案，有望实现市场突破。 Retatrutide：虽上市时间相对较晚，但凭借三重激动机制带来的顶级疗效，预计将定位于治疗严重肥胖伴多种并发症的 “同类最佳” 疗法，占据重要市场份额。 口服制剂：在两款晚期口服 GLP-1 药物中，无需空腹服用且疗效媲美司美格鲁肽的小分子药物 Orforglipron 市场前景更被看好；而口服司美格鲁肽因需空腹服用及面临激烈竞争，市场渗透可能受到限制。小结 从传统疗法的举步维艰到 GLP-1 类药物的强势崛起，再到新一代多靶点、多功能疗法的加速迭代，肥胖治疗领域正经历前所未有的变革。当前及下一代肥胖药物凭借更优的疗效、创新的作用机制和潜在的协同效应，有望进一步拓宽肥胖症药物治疗的边界，为患者带来更全面的健康改善。随着市场竞争的不断加剧和技术的持续突破，肥胖治疗市场的快速迭代才刚刚拉开序幕，未来将为全球肥胖人群带来更多健康希望。 参考资料：Carles Recasens-Alvarez et al. The evolution of the obesity drug market. Nature reviews drug discovery（2025） 识别微信二维码，可添加药时空小编 请注明：姓名+研究方向！

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至12月26日15点59分，近期共有 235 本期刊发布了 875 篇文章，其中糖尿病相关的文章共 207 篇，覆盖 29 个领域的内容。中国专家参与发表的文章有 43 篇。今日，影响因子最高的文章刊登在 Progress in retinal and eye research (IF: 14.700) 期刊上。 今日头条 Headlines 01 Alzheimer's & dementia IF: 11.100 血糖失调与炎症对认知功能及大脑结构的独立与协同影响 van Gils, Veerle, Gómez-Martínez, Carlos, Schram, Miranda T, Blokland, Gabriëlla A M, Fanelli, Giuseppe, Bralten, Janita, etc. 一项发表于Alzheimer's & Dementia期刊的新研究，深入探讨了血糖异常与身体慢性炎症对大脑健康的影响。该研究由Veerle van Gils、Carlos Gómez-Martínez等多位学者共同完成，基于大规模人群队列“The Maastricht Study”，旨在明确血糖问题与炎症是各自独立发挥作用，还是会“联手”加速认知能力下降和大脑萎缩。 研究纳入了2,832名参与者，其中1,745人完成了长达9年的认知功能追踪，2,523人接受了脑部磁共振成像扫描。研究者评估了参与者的血糖状态（包括正常、糖尿病前期和2型糖尿病）、血糖控制水平（糖化血红蛋白[HbA1c]），并通过测量血液中多种炎症标志物计算出一个综合的炎症评分。核心目标是分析这些因素与整体认知功能变化以及大脑关键结构体积之间的关联。 分析结果揭示了几个关键发现。在认知功能方面，研究未发现血糖状态分类与炎症评分之间存在显著的协同放大效应。然而，两者均显示出独立的负面影响：患有2型糖尿病以及体内炎症水平较高的个体，在9年随访期内表现出更快的整体认知功能下降速度。值得注意的是，糖尿病前期状态本身并未显示出与认知衰退的独立关联。 一个有趣的交互作用出现在血糖控制指标上。研究发现，糖化血红蛋白与炎症评分之间存在显著交互作用。具体而言，与炎症程度较高的人相比,在那些体内炎症水平相对较低的个体中，较高的糖化血红蛋白（意味着血糖控制较差）与更严重的认知衰退显著相关。这提示，炎症水平较低的个体可能对血糖失调所带来的认知危害更为敏感。 在大脑结构方面，研究也未发现血糖指标与炎症对脑体积存在协同效应。但各自的影响模式有所不同。全脑灰质体积的减少，与患有2型糖尿病、糖化血红蛋白水平较高以及炎症评分升高均独立相关。而全脑白质体积的减少，则主要与血糖异常状态（包括2型糖尿病和糖尿病前期）相关，与炎症水平无关。海马体体积的缩小，与2型糖尿病和较高的糖化血红蛋白水平独立相关。 综上所述，这项研究指出，血糖失调（特别是2型糖尿病和血糖控制不佳）与全身性慢性炎症，在很大程度上是独立地损害认知功能和大脑结构的风险因素。同时，研究也提示个体的炎症背景可能调节了血糖对认知的影响，在炎症水平不高的人群中，严格控制血糖对于保护认知能力可能具有特别重要的意义。这些发现强调了在管理血糖异常以维护大脑健康时，同时关注并控制炎症水平的重要性。 本文由 韩玉莲 编辑 扫描二维码查看源文 Alzheimer's & dementia | Volume 21, Issue Suppl 3 10.1002/alz70857_100484 02 Cardiovascular Diabetology IF: 10.600 他汀类药物治疗期间新发糖尿病与心血管结局的关联：一项全国性倾向匹配队列研究 Sung, Ki-Chul, Kang, Dongwoo, Lee, Jungkuk, Lee, Seung-Jae, Cho, Eun Joo, Jeong, Jin-Ok, etc. 一项基于韩国大规模人群数据的最新研究，为他汀类药物治疗期间发生的新发2型糖尿病与心血管长期风险之间的关系提供了新的见解。该研究结果近日发表于期刊Cardiovascular Diabetology。 他汀类药物是预防心血管疾病的基石性药物，然而，其可能增加新发糖尿病风险的问题一直备受关注。但一个关键且尚未完全明确的核心临床问题是：在他汀治疗过程中出现的糖尿病，是否预示着未来发生心脏病或卒中等严重心血管事件的风险会更高？为了回答这一问题，由Sung, Ki-Chul等人领导的研究团队开展了一项全国性的大型回顾性队列研究。 研究者利用韩国国家健康保险服务数据库中2009年至2020年的数据，纳入了近150万成年人的信息，设计了两项对比分析。在第一项分析中，研究团队识别出4371例连续服用他汀类药物至少730天后才被新诊断为2型糖尿病的患者。为了进行公平比较，研究人员通过倾向评分匹配方法，为这组“他汀期间新发糖尿病”的患者，一一匹配了另一组患者：这些患者在被诊断为糖尿病后才开始服用他汀，且他们的年龄、性别和初始的低密度脂蛋白胆固醇水平均与新发糖尿病组相当。 结果发现，与那些先有糖尿病再开始他汀治疗的患者相比，在他汀治疗期间新发糖尿病的患者，其发生主要不良心血管事件的风险反而显著降低了约39%。进一步分析显示，这种风险降低主要归因于卒中风险的下降，降幅接近50%。该研究的核心发现表明，在他汀治疗过程中出现的糖尿病，其心血管风险特征可能不同于在启动他汀前已存在的糖尿病。 在研究的第二部分，研究者将4191例他汀治疗期间新发糖尿病的患者，与另一组在相同观察期内一直服用他汀但始终未患糖尿病的患者进行了1:1匹配。这项比较旨在回答另一个临床关切问题：与他汀治疗下维持血糖正常的人相比，新发糖尿病是否会带来额外的心血管危害？ 分析结果显示，与持续无糖尿病的他汀使用者相比，在他汀治疗期间新发糖尿病的患者，其发生主要不良心血管事件的风险并未显著增加。同时，两组之间的全因死亡率也没有观察到统计学上的显著差异。这表明，在他汀治疗背景下新发的糖尿病，并未像传统糖尿病那样，立即转化为显著增高的心血管事件或死亡风险。 这项研究通过对大规模真实世界数据的深入分析，为他汀治疗、新发糖尿病与心血管结局之间的复杂关系提供了新的证据。研究结果提示，临床医生在评估他汀治疗期间新发糖尿病患者的长期风险时，可能需要采取与处理既往已确诊糖尿病患者不同的视角。 本文由 韩玉莲 编辑 扫描二维码查看源文 Cardiovascular Diabetology | Volume 24, Issue 1 10.1186/s12933-025-03003-0 03 Alzheimer's & dementia IF: 11.100 不同胰高血糖素样肽-1受体激动剂（利拉鲁肽、司美格鲁肽、度拉糖肽）对阿尔茨海默病及相关痴呆风险的影响比较：一项基于退伍军人队列的观察性研究 Sarwal, Amara, Singh, Ravinder, Wei, Guo, Hartsell, Sydney E, Nevers, McKenna R, Katkam, Niharika, etc. 近日，一项发表于Alzheimer's & Dementia期刊的研究，对三类广泛用于治疗2型糖尿病的胰高血糖素样肽-1受体激动剂（GLP-1RA）——利拉鲁肽、司美格鲁肽和度拉糖肽——在阿尔茨海默病及相关痴呆（AD/ADRD）风险方面的潜在差异进行了深入探讨。该研究提示，在这三种GLP-1RA药物中，其对于神经认知结局的影响可能并不相同。 尽管既往有研究提示GLP-1RA类药物可能与较低的痴呆风险相关，但同类药物内部不同品种之间的具体效应差异，仍是临床实践中一个有待厘清的问题。为了模拟比较这三种药物的效果，研究团队采用了“阳性对照，新用药者”的观察性研究设计，利用美国退伍军人事务部的健康管理数据展开分析。 研究纳入了2018年1月1日至2021年12月31日期间，被诊断为2型糖尿病、正在服用二甲双胍、并且开始使用利拉鲁肽、司美格鲁肽或度拉糖肽其中一种药物的退伍军人。所有参与者在研究开始时均无痴呆诊断记录，并且排除了既往使用过其他GLP-1RA、SGLT2抑制剂或甘精胰岛素的患者，最终共有21,173名患者被纳入分析。研究随访至2023年3月31日。 研究人群的平均年龄为63岁，其中女性占9%，非洲裔占17%。在药物选择上，25%的患者起始使用利拉鲁肽，50%使用司美格鲁肽，另外25%使用度拉糖肽。为了尽可能控制年龄、基础疾病等混杂因素的影响，使不同用药组之间更具可比性，研究人员采用了先进的统计学方法——基于广义倾向评分的逆概率加权法进行处理。 在平均随访期内，共观察到679例AD/ADRD事件和1,428例死亡事件。未经校正的分析显示，司美格鲁肽组的AD/ADRD发生率在三者中最高。在经过逆概率加权校正后的Cox比例风险模型中，研究得出了更精确的比较结果。分析结果显示，起始使用利拉鲁肽的患者，其发生AD/ADRD的风险显著低于起始使用司美格鲁肽的患者（风险比[HR]0.68），而与度拉糖肽相似。 除了神经认知结局，研究还关注了死亡风险。结果表明，在降低全因死亡风险方面，利拉鲁肽同样显示出优势，其风险低于司美格鲁肽和度拉糖肽。当将AD/ADRD和死亡合并为一个复合终点时，利拉鲁肽的风险也是三者中最低的。 综上所述，这项基于大型真实世界数据的研究表明，在常用的非艾塞那肽类GLP-1RA药物中，利拉鲁肽在降低AD/ADRD风险方面优于司美格鲁肽，在降低死亡风险方面也显示出优势。度拉糖肽在预防AD/ADRD方面与利拉鲁肽效果相当，但并未观察到其在降低死亡风险方面的额外获益。这些发现为临床医生在选择GLP-1RA药物时，综合考虑患者的心血管代谢管理与潜在的神经保护需求，提供了新的参考维度。 本文由 韩玉莲 编辑 扫描二维码查看源文 Alzheimer's & dementia | Volume 21, Issue Suppl 3 10.1002/alz70857_101831 中国发表（43） China Journal of controlled release IF: 11.500Ahead of Print.No.01Non-invasive co-delivery of Axitinib and telmisartan via LDH-based nanocarriers for synergistic VEGF/Ang-2 inhibition in ocular neovascular diseases基于LDH的纳米载体非侵入性共递送Axitinib与Telmisartan用于协同抑制VEGF/Ang-2治疗眼部新生血管疾病DOI: 10.1016/j.jconrel.2025.114574 Prog Retin Eye Res IF: 14.700Ahead of Print.No.02Glymphatic Transport and Ocular Diseases类淋巴转运与眼部疾病DOI: 10.1016/j.preteyeres.2025.101433 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.03Comprehensive risk factor control and its biomarker-mediated association with diabetic microvascular complications综合风险因素控制及其与糖尿病微血管并发症的生物标志物介导关联DOI: 10.1111/dom.70403 British journal of ophthalmology IF: 03.500Ahead of Print.No.04Efficacy and safety of anti-VEGF monoclonal antibody 601 for macular oedema in retinal vein occlusion: two phase IIa randomised clinical trials抗血管内皮生长因子单克隆抗体601治疗视网膜静脉阻塞继发黄斑水肿的有效性和安全性：两项IIa期随机临床试验DOI: 10.1136/bjo-2025-327845 Shengwu yixue gongchengxue zazhiVolume 42, Issue 6No.05[Application and research progress of metal-organic framework materials in skin repair]金属有机框架材料在皮肤修复中的应用与研究进展DOI: 10.7507/1001-5515.202411036 Shengwu yixue gongchengxue zazhiVolume 42, Issue 6No.06[Adaptive lesion-aware fusion network for joint grading of multiple fundus diseases]面向多眼底疾病联合分级的自适应病灶感知融合网络DOI: 10.7507/1001-5515.202411032 BMJ open IF: 02.300Volume 15, Issue 12No.07Clinical characteristics and outcomes of patients with type 2 diabetes mellitus and chronic kidney disease from two new-user medication cohorts: a retrospective cohort study using regional electronic health records database in China2型糖尿病合并慢性肾脏病患者的临床特征与结局：一项基于中国区域电子健康记录数据库的两项新用药队列回顾性研究DOI: 10.1136/bmjopen-2025-106126 BMJ open IF: 02.300Volume 15, Issue 12No.08Understanding the barriers for prevention and detection of chronic kidney disease among healthcare professionals in Syria: a qualitative study了解叙利亚医疗保健专业人员预防和检测慢性肾脏病的障碍：一项定性研究DOI: 10.1136/bmjopen-2025-103959 J Agric Food Chem IF: 06.200Ahead of Print.No.09Triterpene Saponins from the Bran of Chenopodium quinoa Willd. and Their α-Glucosidase Inhibition Activity藜麦麸皮中三萜皂苷的分离鉴定及其α-葡萄糖苷酶抑制活性研究DOI: 10.1021/acs.jafc.5c12163 Prog Retin Eye Res IF: 14.700Ahead of Print.No.10Mitochondria in Corneal Physiology and Pathology: A Mechanistic Perspective线粒体在角膜生理与病理中的作用：机制视角DOI: 10.1016/j.preteyeres.2025.101432 Int J Biol Macromol IF: 08.500Ahead of Print.No.11The development status and research progress of hypoglycemic peptides: A review降糖肽的发展现状与研究进展：综述DOI: 10.1016/j.ijbiomac.2025.149859 Food chemistry IF: 09.800Ahead of Print.No.12Rice bran extract with α-glucosidase inhibitory activity: Preparation, in vitro evaluation and molecular mechanism具有α-葡萄糖苷酶抑制活性的大米糠提取物：制备、体外评估及分子机制研究DOI: 10.1016/j.foodchem.2025.147665 Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.13Hydrogel composite nanomaterials for diabetic wound treatment用于糖尿病伤口治疗的水凝胶复合纳米材料DOI: 10.1016/j.colsurfb.2025.115392 BMJ open IF: 02.300Volume 15, Issue 12No.14Association between body roundness index and kidney stone risk in Chinese adults: an ultrasound-based cross-sectional study中国成年人身体圆度指数与肾结石风险的关联：一项基于超声的横断面研究DOI: 10.1136/bmjopen-2025-101716 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.15Phosphodiesterase: insight from molecular targets for glycolipid metabolism磷酸二酯酶：来自糖脂代谢分子靶点的见解DOI: 10.1016/j.bbrc.2025.153188 BMC cancer IF: 03.400Ahead of Print.No.16The effect of exercise intervention on IGF axis and metabolic markers regulation in breast cancer patients: a systematic review with pairwise, network, and dose-response meta-analyses运动干预对乳腺癌患者IGF轴与代谢标记物调节的影响：一项包含配对、网络及剂量反应荟萃分析的系统综述DOI: 10.1186/s12885-025-15475-0 BMC endocrine disorders IF: 03.300Ahead of Print.No.17Risk factors for hypoglycaemia in adults with type 1 diabetes: a systematic review and meta-analysis成人1型糖尿病患者低血糖的危险因素：一项系统综述与荟萃分析DOI: 10.1186/s12902-025-02122-9 BMJ open IF: 02.300Volume 15, Issue 12No.18Effects of multimodal mobile health interventions on cardiovascular risk factor management in patients with diabetes: a systematic review and meta-analysis多模式移动健康干预对糖尿病患者心血管危险因素管理的影响：一项系统综述与荟萃分析DOI: 10.1136/bmjopen-2025-108371 Journal of hazardous materials IF: 11.300Ahead of Print.No.19Metformin drives the antibiotic resistome in activated sludge by reshaping microbial communities and promoting horizontal gene transfer二甲双胍通过重塑微生物群落和促进水平基因转移驱动活性污泥中的抗生素抗性组DOI: 10.1016/j.jhazmat.2025.140887 Environ Sci Technol IF: 11.300Ahead of Print.No.20Combining Suspect Screening with Large Language Model-Based Text Mining to Comprehensively Characterize Organic Compounds in Human Milk Associated with Pregnancy Complications结合疑似筛选与大语言模型文本挖掘全面表征与妊娠并发症相关的人乳中有机化合物DOI: 10.1021/acs.est.5c12937 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.21Biomarkers在老年人群中高血压在甘油三酯葡萄糖体重指数与血管性脑损伤MRI标志物关联中的作用DOI: 10.1002/alz70856_101909 BMC nephrology IF: 02.400Ahead of Print.No.22Urinary stress hormones and their metabolites as predictive biomarkers for CKD with diabetes尿应激激素及其代谢物作为伴糖尿病慢性肾脏病的预测性生物标志物DOI: 10.1186/s12882-025-04717-9 Environ Health (Wash) IF: 06.300Volume 3, Issue 12No.23Prenatal Exposure to PM(2.5) Increased Vulnerability to a Second Hit of a High-Fat Diet in Mouse Offspring产前暴露于PM2.5增加小鼠后代对高脂饮食“二次打击”的易感性DOI: 10.1021/envhealth.5c00262 Int J Womens Health IF: 02.600Volume 17, Issue No.24Impact of Diane-35 on Hormone Levels and Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome: A Retrospective AnalysisDiane-35对多囊卵巢综合征患者激素水平及妊娠结局的影响：一项回顾性分析DOI: 10.2147/IJWH.S557855 Frontiers in psychiatry IF: 03.200Volume 16, Issue No.25First exposure to second-generation antipsychotics alters gut microbiota and metabolic profiles in patients with glucose-lipid metabolism disorders首次服用第二代抗精神病药物改变葡萄糖-脂质代谢紊乱患者的肠道菌群及代谢谱DOI: 10.3389/fpsyt.2025.1722760 Frontiers in psychiatry IF: 03.200Volume 16, Issue No.26Quantitative computed tomography for assessing body composition in schizophrenia: a potential indicator of insulin resistance定量CT评估精神分裂症患者身体成分：胰岛素抵抗的潜在指示指标DOI: 10.3389/fpsyt.2025.1676939 Frontiers in medicine IF: 03.000Volume 12, Issue No.27A study on predictive nomogram for abdominal wall hernia in peritoneal dialysis patients based on multicenter data基于多中心数据的腹膜透析患者腹壁疝预测列线图研究DOI: 10.3389/fmed.2025.1624861 Frontiers in pharmacology IF: 04.800Volume 16, Issue No.28Correction: DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathwayDICAR/DICAR-JP通过miR-361-5p/PRMT1通路发挥脑卒中治疗作用：勘误DOI: 10.3389/fphar.2025.1756716 Frontiers in pharmacology IF: 04.800Volume 16, Issue No.29DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathwayDICAR/DICAR-JP通过miR-361-5p/PRMT1通路在脑卒中发挥治疗作用DOI: 10.3389/fphar.2025.1721188 Environ Health (Wash) IF: 06.300Volume 3, Issue 12No.30Chronic Ozone Exposure and Its Role in the Development of Age-Related Cataracts: A Comprehensive Analysis长期臭氧暴露在年龄相关性白内障发展中的作用：一项全面分析DOI: 10.1021/envhealth.5c00086 Toxicology research IF: 02.100Volume 14, Issue 6No.31Mmu-miR-664-5p contributes to high glucose-induced MPC5 podocyte injury via its target RUNX3mmu-miR-664-5p 通过靶向 RUNX3 促进高糖诱导的 MPC5 足细胞损伤DOI: 10.1093/toxres/tfaf185 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.32Clinical value of BISAP score combined with low-density lipoprotein cholesterol and ascites in early prediction of hypertriglyceridemic severe acute pancreatitisBISAP评分联合低密度脂蛋白胆固醇与腹水在早期预测高甘油三酯性重症急性胰腺炎中的临床价值DOI: 10.3389/fendo.2025.1722057 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.33Monocyte human leukocyte antigen-DR-mediated diabetic nephropathy progression is a promising therapeutic target单核细胞人白细胞抗原-DR介导的糖尿病肾病进展是一个有前景的治疗靶点DOI: 10.3389/fendo.2025.1733139 ACS Biomater Sci Eng IF: 05.500Ahead of Print.No.34In Silico-Guided Rumex abyssinicus-Loaded PVA/PVP Nanofiber Mats for Sustainable Wound Healing计算机模拟指导的 Rumex abyssinicus 负载 PVA/PVP 纳米纤维垫用于可持续伤口愈合DOI: 10.1021/acsbiomaterials.5c01926 J Orthop Surg Res IF: 02.800Ahead of Print.No.35Periosteal distraction improves blood flow and regulates inflammatory response to accelerate foot ulcer healing in diabetic rats骨膜牵张通过改善血流和调节炎症反应加速糖尿病大鼠足部溃疡愈合DOI: 10.1186/s13018-025-06580-8 Journal of clinical nursing IF: 03.500Ahead of Print.No.36Comment on "Health-Promoting Behaviour Patterns in Women With Gestational Diabetes Mellitus: A Latent Class Analysis and Association With Prenatal Depression"评“Health-Promoting Behaviour Patterns in Women With Gestational Diabetes Mellitus: A Latent Class Analysis and Association With Prenatal Depression”DOI: 10.1111/jocn.70190 iScience IF: 04.100Volume 28, Issue 12No.37Comparative effects of hypoxic exercise training modalities on cardiometabolic health: A systematic review and network meta-analysis低氧运动训练模式对心脏代谢健康影响的比较：一项系统综述与网络荟萃分析DOI: 10.1016/j.isci.2025.114194 Metabolism open IF: 02.700Volume 28, Issue No.38Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity脱氧胆酸和脂磷壁酸通过TGR5/STAT3和TLR2/NF-κB协同驱动巨噬细胞M2/M1极化，促进肥胖中的肝癌进展DOI: 10.1016/j.metop.2025.100420 Frontiers in immunology IF: 05.900Volume 16, Issue No.39Immunometabolism and male reproductive function: linking inflammation, oxidative stress, and declining fertility免疫代谢与男性生殖功能：连接炎症、氧化应激与生育力下降DOI: 10.3389/fimmu.2025.1736492 Int J Nanomedicine IF: 06.500Volume 20, Issue No.40Advances in Microneedle Drug Delivery for Obesity: Mechanisms, Applications, and Perspectives微针给药治疗肥胖的研究进展：机制、应用与展望DOI: 10.2147/IJN.S566132 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.41Insights from RNA sequencing techniques revealing the molecular mechanisms associated with diabetic retinopathyRNA测序技术揭示糖尿病视网膜病变相关分子机制的见解DOI: 10.1007/s40200-025-01796-1 BMC endocrine disorders IF: 03.300Ahead of Print.No.42Lower hemoglobin levels may increase the risk of diabetic retinopathy in patients with type 2 diabetes mellitus较低的血红蛋白水平可能增加 2 型糖尿病患者发生糖尿病视网膜病变的风险DOI: 10.1186/s12902-025-02135-4 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.43Drug Development比较达格列净、利拉鲁肽与阿卡波糖对2型糖尿病患者嗅觉刺激下初级嗅觉皮层定向功能连接及局部激活的影响DOI: 10.1002/alz70859_097012 其他发布内容（161） More Published Articles Kidney international IF: 12.600Ahead of Print.No.01Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction抑制钠-葡萄糖协同转运蛋白2可改善年龄依赖性的肾脏微血管稀疏DOI: 10.1016/j.kint.2025.12.011 BMJ open IF: 02.300Volume 15, Issue 12No.02Disease-modifying effect, safety and optimal dose of oral semaglutide tablets for patients with Parkinson's disease (MOST-ABLE study): protocol for a randomised, double-blind, placebo-controlled study口服司美格鲁肽片对帕金森病患者的疾病修饰效应、安全性及最佳剂量研究（MOST-ABLE研究）：一项随机、双盲、安慰剂对照研究方案DOI: 10.1136/bmjopen-2025-112318 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 4No.03Dementia Care Research and Psychosocial Factors老年华人轻度ADRD患者及照护伙伴对连续血糖监测的满意度研究DOI: 10.1002/alz70858_103175 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.04Clinical Manifestations临床表现DOI: 10.1002/alz70857_106758 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.05Drug Development药物开发研究：探索现有药物延缓衰老与预防阿尔茨海默病的潜力DOI: 10.1002/alz70859_102599 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 4No.06Dementia Care Research and Psychosocial Factors痴呆症护理研究与心理社会因素DOI: 10.1002/alz70858_101689 BMC endocrine disorders IF: 03.300Ahead of Print.No.07Postoperative hungry bone syndrome in primary hyperparathyroidism: risk factors and outcomes at a South African tertiary centre原发性甲状旁腺功能亢进症术后饥饿骨综合征：南非一家三级医疗中心的风险因素和结局DOI: 10.1186/s12902-025-02140-7 BMC public health IF: 03.600Ahead of Print.No.08Cohort profile: the Lebanon Study on Aging and HeAlth (LSAHA)队列简介：黎巴嫩老龄化与健康研究（LSAHA）DOI: 10.1186/s12889-025-25983-0 BMC infectious diseases IF: 03.000Ahead of Print.No.09Comorbidities in hospitalized patients with herpes zoster: an Italian retrospective observational study in the years 2011-2023住院带状疱疹患者的合并症：一项2011-2023年意大利回顾性观察性研究DOI: 10.1186/s12879-025-12319-x Scientific reports IF: 03.900Ahead of Print.No.10Clinical predictive fusion network for accurate disease prediction in patient cohorts用于患者队列精准疾病预测的临床预测融合网络DOI: 10.1038/s41598-025-33645-9 Scientific reports IF: 03.900Ahead of Print.No.11Deep learning-based joint analysis of diabetic retinopathy and glaucoma in retinal fundus images基于深度学习的视网膜眼底图像中糖尿病视网膜病变与青光眼的联合分析DOI: 10.1038/s41598-025-32991-y Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.12Clinical Manifestations临床表现DOI: 10.1002/alz70857_105263 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 4No.13Dementia Care Research and Psychosocial Factors阿尔茨海默病治疗乐观态度在美国老年人群中的特征及相关因素分析DOI: 10.1002/alz70858_107068 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.14Clinical Manifestations步态速度与淀粉样蛋白在认知未受损的非西班牙裔白人和西班牙裔/拉丁裔老年人中的关联研究DOI: 10.1002/alz70857_106776 Bone IF: 03.600Ahead of Print.No.15Repurposing osteoporosis medications for other diseases: a narrative review by the European Calcified Tissue Society (ECTS)骨质疏松药物的老药新用：欧洲钙化组织协会(ECTS)叙述性综述DOI: 10.1016/j.bone.2025.117769 Top Companion Anim Med IF: 01.300Ahead of Print.No.16Microfilaruria of Morphologically Identified Dirofilaria repens and Brugia spp. in one cat and two dogs: case series一例猫和两例犬中经形态学鉴别的Dirofilaria repens与Brugia spp.微丝蚴尿：病例系列报告DOI: 10.1016/j.tcam.2025.101042 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.17Clinical Manifestations具有心血管危险因素的社区居住阿拉伯人和犹太人的认知主诉：体力活动的作用DOI: 10.1002/alz70857_103624 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.18Biomarkers血管因素、种族差异与大脑健康：DVCID研究初步分析DOI: 10.1002/alz70856_103824 Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.19Group B Streptococcus colonization in pregnant women and vertical transmission to neonates in Crete Greece: Incidence and risk factors希腊克里特岛孕妇B族链球菌定植及垂直传播至新生儿：发病率和危险因素DOI: 10.1016/j.ejogrb.2025.114913 Burns IF: 02.900Ahead of Print.No.20Looking beyond the scalpel: Assessing patient risk factors for complications following surgical excision of hidradenitis suppurativa超越手术刀：评估化脓性汗腺炎手术切除后并发症的患者风险因素DOI: 10.1016/j.burns.2025.107822 Journal of clinical densitometry IF: 01.600Ahead of Print.No.21Reframing the BMI-BMD-TBS triad in type 2 diabetes: Clinical and policy implications重构2型糖尿病中的BMI-BMD-TBS三合一：临床与政策意义DOI: 10.1016/j.jocd.2025.101659 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.22Synthesis, characterization and molecular insights towards antidiabetic profiling of novel curcumin-derived Schiff base metal complexes新型姜黄素衍生物希夫碱金属复合物的合成、表征及其抗糖尿病活性的分子机制研究DOI: 10.1016/j.bbrc.2025.153131 Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.23Effects of millet consumption on metabolic homeostasis (glycemic control and lipid profiles) in adults: A systematic review小米消费对成人代谢稳态（血糖控制和血脂谱）的影响：一项系统综述DOI: 10.1016/j.dsx.2025.103359 Drug discovery today IF: 07.500Ahead of Print.No.24Piezo1 as a therapeutic target in kidney disease: emerging mechanistic insights and translational potentialPiezo1作为肾病治疗靶点：新机制见解与转化潜力DOI: 10.1016/j.drudis.2025.104592 Globalization and health IF: 04.500Ahead of Print.No.25Tool for assessing food industry commitments and practices to address the double burden of malnutrition: a Delphi study评估食品行业应对双重营养不良负担的承诺与实践的工具：一项德尔菲研究DOI: 10.1186/s12992-025-01175-8 BMC infectious diseases IF: 03.000Ahead of Print.No.26Incident hypertension among adults on ART in Malawi: a nested cohort study马拉维接受ART治疗的成人中新发高血压：一项巢式队列研究DOI: 10.1186/s12879-025-12423-y Esophagus IF: 03.800Ahead of Print.No.27Post-esophagectomy hiatal hernias: a systematic review and meta-analysis食管切除术后食管裂孔疝：一项系统回顾与荟萃分析DOI: 10.1007/s10388-025-01175-y Obesity surgery IF: 03.100Ahead of Print.No.28Minimally Invasive Hypoabsorptive Bariatric Surgery - A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials微创吸收不良型减重手术——一项随机临床试验的系统综述与网络荟萃分析DOI: 10.1007/s11695-025-08443-x Scientific reports IF: 03.900Ahead of Print.No.29The impact of patient's height-adjusted biliopancreatic limb length on short-term outcomes in one-anastomosis gastric bypass患者身高调整的胆胰肢长度对单吻合口胃旁路术短期结局的影响DOI: 10.1038/s41598-025-33280-4 Current obesity reports IF: 11.000Volume 14, Issue 1No.30Obesity, Olfaction and Cognition: A Systematic Review肥胖、嗅觉与认知：系统综述DOI: 10.1007/s13679-025-00678-0 Blood reviews IF: 05.700Ahead of Print.No.31Metabolic alterations in multiple myeloma and extramedullary disease- a novel niche of therapeutic targets多发性骨髓瘤及髓外病变中的代谢改变：一个治疗靶点的新领域DOI: 10.1016/j.blre.2025.101360 Thyroid IF: 06.700Ahead of Print.No.32Weight Gain after Treatment of Hyperthyroidism is Associated with Impairment of Quality of Life甲亢治疗后体重增加与生活质量损害相关DOI: 10.1177/10507256251404868 BMJ military health IF: 01.700Ahead of Print.No.33Implications of obesity in the US military: unfit to serve?美国军队中的肥胖问题：不合格服役？DOI: 10.1136/military-2025-003145 BMJ open respiratory research IF: 03.400Volume 12, Issue 1No.34Digitally assessed home FEV(1) to identify the cause of poorly controlled asthma: a protocol paper for a prospective replicate cohort study基于数字评估的家庭FEV₁识别哮喘控制不佳原因：一项前瞻性重复队列研究方案DOI: 10.1136/bmjresp-2025-003696 J Obes Metab Syndr IF: 07.900Ahead of Print.No.35Letter: Toward Precision in Obesity Diagnosis: Progress, Pitfalls, and the Path Ahead (J Obes Metab Syndr 2025;34:85-7)迈向精准肥胖诊断：进展、挑战与未来方向DOI: 10.7570/jomes25071 Prog Neuropsychopharmacol Biol Psychiatry IF: 03.900Ahead of Print.No.36High-fat diet-induced obesity enhances stress vulnerability and promotes a PTSD-like phenotype in rats高脂饮食诱导的肥胖增强应激易感性并促进大鼠出现PTSD样表型DOI: 10.1016/j.pnpbp.2025.111596 Reproductive toxicology IF: 02.800Ahead of Print.No.37Intestinal Microbiome in Response to Air Pollutant Exposure in Pregestational and Gestational Murine Females and their Male and Female Offspring孕前及孕期雌性小鼠及其雌雄后代肠道微生物组对空气污染物暴露的反应DOI: 10.1016/j.reprotox.2025.109150 Sleep medicine IF: 03.400Ahead of Print.No.38The impact of exercise training on the obstructive sleep apnea endotypes运动训练对阻塞性睡眠呼吸暂停内型的影响DOI: 10.1016/j.sleep.2025.108740 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 4No.39Dementia Care Research and Psychosocial Factors印度人群痴呆症风险因素：来自城乡队列研究的启示DOI: 10.1002/alz70858_102465 npj aging IF: 06.000Ahead of Print.No.40Reversal of proteomic aging with exercise-results from the UK biobank and a 12-week intervention study运动逆转蛋白质组衰老：基于英国生物样本库和12周干预研究的结果DOI: 10.1038/s41514-025-00318-w Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.41Biomarkers轻度认知障碍老年人非药物干预的血液生物标志物：ACT试验研究DOI: 10.1002/alz70856_102229 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.42Accuracy and reliability of a continuous glucose monitoring system with a focus on hypoglycaemia连续血糖监测系统在低血糖范围内的准确性和可靠性研究DOI: 10.1111/dom.70408 J Clin Periodontol IF: 06.800Ahead of Print.No.43Dietary Nitrate Intake and 16S rRNA-Inferred Nitrite-Generating Capacity of the Subgingival Microbiome May Influence Glucose Metabolism: Results From the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS)饮食硝酸盐摄入与基于16S rRNA推断的龈下微生物组亚硝酸盐生成能力可能影响血糖代谢：来自口腔感染、葡萄糖不耐受和胰岛素抵抗研究（ORIGINS）的结果DOI: 10.1111/jcpe.70084 Experimental neurology IF: 04.200Ahead of Print.No.44Effect of hypoglycemia on the diameter of cerebral vasculature in vivo and cerebral ischemia-reperfusion injury in mice低血糖对小鼠体内脑血管直径及脑缺血再灌注损伤的影响DOI: 10.1016/j.expneurol.2025.115605 Brain research IF: 02.600Volume 1872, Issue No.45Examining functional connectivity in metabolic syndrome and small vessel disease: A novel approach to understanding olfactory dysfunction and Alzheimer's disease探究代谢综合征与小血管病中的功能连接：理解嗅觉功能障碍与阿尔茨海默病的新视角DOI: 10.1016/j.brainres.2025.150084 J Foot Ankle Res IF: 02.200Volume 18, Issue 4No.46Diabetic Foot Ulcers in Pakistan: A Silent Epidemic?-A Meta-Analysis of Observational Studies巴基斯坦的糖尿病足溃疡：一场静默的流行病？——一项观察性研究的Meta分析DOI: 10.1002/jfa2.70117 Neuropharmacology IF: 04.600Ahead of Print.No.47Targeting treatment-resistant social anxiety with sitagliptin: effects on social fear and comorbid depressive-like behavior in a preclinical model西格列汀靶向治疗难治性社交焦虑：在临床前模型中对社交恐惧和共病抑郁样行为的作用DOI: 10.1016/j.neuropharm.2025.110812 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.48Drug Development罗望子种子通过调节代谢和氧化应激延缓糖尿病相关神经退行性变的研究DOI: 10.1002/alz70859_106225 J Obes Metab Syndr IF: 07.900Ahead of Print.No.49Diagnostic Accuracy of the Triglyceride-Glucose Derived Indices in Detecting Metabolic Syndrome in Pediatric Patients甘油三酯-葡萄糖衍生指数对儿科患者代谢综合征的诊断准确性研究DOI: 10.7570/jomes25002 BMJ open IF: 02.300Volume 15, Issue 12No.50Associations of left ventricular hypertrophy and poor sleep quality with haemodynamic and cardiometabolic risk factors in adults with hypertension: a cross-sectional study from Pakistan高血压成人左心室肥厚与睡眠质量差与血流动力学和心脏代谢风险因素的关联：一项来自巴基斯坦的横断面研究DOI: 10.1136/bmjopen-2025-109265 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.51Drug Development药物筛选流程的建立与应用DOI: 10.1002/alz70859_102227 Journal of hazardous materials IF: 11.300Ahead of Print.No.52Machine learning-driven prioritization of micropollutants in river water: Integrating ecological and human health risks from a two-year monitoring campaign机器学习驱动的河流水中微污染物优先排序：整合两年监测活动中的生态和人类健康风险DOI: 10.1016/j.jhazmat.2025.140864 Am J Prev Med IF: 04.500Ahead of Print.No.53Natural transitions of non-high-density lipoprotein cholesterol levels in children 9-11 years of age9-11岁儿童非高密度脂蛋白胆固醇水平的自然变化DOI: 10.1016/j.amepre.2025.108243 Heart Failure Reviews IF: 04.200Volume 31, Issue 1No.54Evaluating the role of mavacamten in symptomatic non-obstructive hypertrophic cardiomyopathy: the ODYSSEY-HCM trial评估Mavacamten在症状性非梗阻性肥厚型心肌病中的作用：ODYSSEY-HCM试验DOI: 10.1007/s10741-025-10578-z Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.55Biomarkers血液生物标志物与中年认知功能相关DOI: 10.1002/alz70856_101201 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.56Biomarkers2型糖尿病合并抑郁症患者的凋亡蛋白与脑血管影像标志物关联研究DOI: 10.1002/alz70856_100566 Psychology, health & medicine IF: 01.900Ahead of Print.No.57The link between depression, eating behaviors and body mass index抑郁、饮食行为与体重指数之间的关联DOI: 10.1080/13548506.2025.2604272 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.58Clinical Manifestations睡眠特征与认知障碍的临床关联：一项基于四个队列的年龄分层分析DOI: 10.1002/alz70857_103902 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.59Clinical Manifestations命名障碍与脑结构改变在认知障碍中的关联：一项基于台湾社区人群的影像学研究DOI: 10.1002/alz70857_103211 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.60Biomarkers生物标志物DOI: 10.1002/alz70856_101317 Cell reports IF: 06.900Ahead of Print.No.61Maternal diet shapes milk bile acids to regulate neonatal growth through TGR5母体饮食通过TGR5受体塑造乳汁胆汁酸以调控新生儿生长DOI: 10.1016/j.celrep.2025.116744 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.62Biomarkers社区动脉粥样硬化风险研究中的多器官衰老与痴呆风险DOI: 10.1002/alz70856_100937 JMIR IF: 06.000Volume 27, Issue No.63Just-In-Time Adaptive Interventions for Weight Management Among Adults With Excess Body Weight: Scoping Review面向超重成人体重管理的适时适应性干预：范围综述DOI: 10.2196/76625 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.64Basic Science and Pathogenesis高热量高脂肪饮食调节阿尔茨海默病转基因大鼠模型中异常的神经元网络动力学DOI: 10.1002/alz70855_107129 Hirurgia. ХирургияVolume 2025, Issue 11. Vyp. 2No.65[Role of gut microbiota in aging processes]肠道菌群在衰老进程中的作用DOI: 10.17116/hirurgia202511267 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.66Clinical Manifestations临床启示DOI: 10.1002/alz70857_105637 Internal medicine journal IF: 01.500Ahead of Print.No.67Navigating hypokalaemia in diabetic ketoacidosis: a call for pragmatic insulin initiation guidelines应对糖尿病酮症酸中毒中的低钾血症：呼吁实用的胰岛素起始指南DOI: 10.1111/imj.70289 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.68Clinical Manifestations阿尔茨海默病与糖尿病关联的交叉组织蛋白质组学研究DOI: 10.1002/alz70857_102725 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.69Clinical Manifestations阿尔茨海默病患者的内隐记忆：评估性条件反射的临床意义DOI: 10.1002/alz70857_104127 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.70Biomarkers社会经济剥夺与认知障碍患者的海马亚区及杏仁核萎缩相关DOI: 10.1002/alz70856_100670 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.71Biomarkers心血管风险与血浆阿尔茨海默病生物标志物在认知正常成人中的相关性DOI: 10.1002/alz70856_100656 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.72Clinical Manifestations临床表现：一例巨细胞动脉炎合并神经精神症状的病例报告DOI: 10.1002/alz70857_102104 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.73Drug Development靶向代谢应激的药物研发：SGLT1/2抑制剂对认知功能影响的研究DOI: 10.1002/alz70859_098593 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.74Clinical Manifestations临床特征：基于新加坡人群的轻度认知障碍风险因素与数字大脑功能筛查研究DOI: 10.1002/alz70857_101882 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.75Biomarkers阿尔茨海默病患者中自然发生淀粉样蛋白相关成像异常-含铁血黄素沉积的危险因素DOI: 10.1002/alz70856_101287 Annals of neurology IF: 07.700Ahead of Print.No.76Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease利用电子健康记录测试多病共存对阿尔茨海默病血浆生物标志物解读的影响DOI: 10.1002/ana.78114 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.77Drug Development药物开发DOI: 10.1002/alz70859_099189 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.78BiomarkersPOINTER与FHS研究中脑血管影像标志物与血管风险因素和认知关系的一致性评估DOI: 10.1002/alz70856_100134 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.79Drug Development药物开发研究：酮酯补充剂对代谢综合征患者脑代谢和认知功能的影响DOI: 10.1002/alz70859_097825 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.80Drug Development胰高血糖素样肽-1受体激动剂治疗神经疾病：系统综述与荟萃分析DOI: 10.1002/alz70859_098720 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.81Drug Development芦丁与维生素E联合应用通过调节肠道菌群缓解2型糖尿病相关记忆损伤的药物开发研究DOI: 10.1002/alz70859_097101 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.82BiomarkersDPP-4抑制剂与2型糖尿病老年患者血浆阿尔茨海默病相关生物标志物变化的关联：一项来自J-MINT的探索性分析DOI: 10.1002/alz70856_101474 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.83Basic Science and Pathogenesis在阿尔茨海默病APP/PS1和HuAmy-APP/PS1小鼠模型中评估胰淀素被动免疫疗法的安全性特征DOI: 10.1002/alz70855_106792 Int J Eat Disord IF: 04.300Ahead of Print.No.84Examining Avoidant/Restrictive Food Intake Disorder and Food Selectivity Across the Body Mass Index Spectrum in Children Presenting at an Outpatient, Multidisciplinary Feeding Clinic在多学科门诊喂养诊所就诊的儿童中，探究回避/限制性食物摄入障碍和食物选择性在体重指数谱上的表现DOI: 10.1002/eat.70017 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.85Basic Science and Pathogenesis在TgF344-AD大鼠阿尔茨海默病早期症状期，膳食宏量营养素摄入对大脑的性别特异性影响DOI: 10.1002/alz70855_107444 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.86Basic Science and Pathogenesis评估不同人群基因组信息痴呆风险报告：在多个队列中验证临床、多基因风险评分及其与家族史和APOE的结合DOI: 10.1002/alz70855_107015 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.87Basic Science and Pathogenesis肥胖在阿尔茨海默病发病机制中的作用：炎症与神经退行性变的关联性DOI: 10.1002/alz70855_106637 Curēus IF: 01.300Volume 17, Issue 12No.88Prostatic Abscess Due to Dual Infection With Mycobacterium tuberculosis and Stenotrophomonas maltophilia结核分枝杆菌与嗜麦芽窄食单胞菌双重感染所致前列腺脓肿DOI: 10.7759/cureus.99858 Metabolism open IF: 02.700Volume 28, Issue No.89Association of sleep quality and glycemic variability among South Indian rural patients with Type-2 diabetes mellitus南印度农村2型糖尿病患者睡眠质量与血糖变异性的关联研究DOI: 10.1016/j.metop.2025.100427 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.90Basic Science and Pathogenesis阿尔茨海默病非人灵长类模型中与年龄相关的血糖处理和执行功能变化DOI: 10.1002/alz70855_106968 Ther Adv Neurol Disord IF: 04.100Volume 18, Issue No.91Efficacy of intravenous immunoglobulin in patients with chronic inflammatory demyelinating polyneuropathy with or without diabetes: insights from a multicenter prospective comparative study静脉注射免疫球蛋白在伴有或不伴有糖尿病的慢性炎性脱髓鞘性多神经根神经病患者中的有效性：一项多中心前瞻性比较研究的启示DOI: 10.1177/17562864251401496 Curēus IF: 01.300Volume 17, Issue 12No.92Treatment-Induced Diabetic Neuropathy: A Case Report on Multimodal Pain Management in a Young Patient With Type I Diabetes治疗诱导性糖尿病神经病变：一例年轻1型糖尿病患者的多模式疼痛管理病例报告DOI: 10.7759/cureus.99918 bioRxivVolume 2025, Issue No.93Multiomics Integration Reveals a Metabolic Myopathy in Cardiometabolic HFpEF多组学整合揭示心脏代谢性HFpEF中存在代谢性肌病DOI: 10.64898/2025.12.15.694522 Frontiers in dementiaVolume 4, Issue No.94BACE1 at the crossroads of a vicious circle between Alzheimer's disease and diabetes mellitusBACE1：阿尔茨海默病与糖尿病恶性循环的交汇点DOI: 10.3389/frdem.2025.1730524 bioRxivVolume 2025, Issue No.95Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis人类胰腺的单细胞与空间图谱解析揭示囊性纤维化中β细胞功能障碍的驱动因素DOI: 10.64898/2025.12.14.694120 bioRxivVolume 2025, Issue No.96Insulin-Regulated Actin Dynamics is Disrupted in a Human Keratinocyte Model of Hailey Hailey Disease胰岛素调节的肌动蛋白动态在人角质形成细胞Hailey Hailey疾病模型中被破坏DOI: 10.64898/2025.12.15.694174 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.97Diabetes-Induced depression: A molecular perspective糖尿病诱发的抑郁症：分子视角DOI: 10.1007/s40200-025-01806-2 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.98Drug Development药物开发DOI: 10.1002/alz70859_096869 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.99Clinical Manifestations痴呆亚型与血管风险因素：印度南部队列的临床及影像特征DOI: 10.1002/alz70857_105449 Frontiers in medicine IF: 03.000Volume 12, Issue No.100Clinical characteristics and outcomes of liver abscesses: a 12-year retrospective analysis from a tertiary care center in the United Arab Emirates肝脓肿的临床特征与结局：来自阿拉伯联合酋长国一家三级医疗中心的12年回顾性分析DOI: 10.3389/fmed.2025.1673473 Journal of pain research IF: 02.500Volume 18, Issue No.101Assessment of the Burden of Chronic Neck and/or Shoulder Pain on Quality of Life Among Saudi Adults: A Cross-Sectional Study评估慢性颈部和/或肩部疼痛对沙特成年人生活质量的负担：一项横断面研究DOI: 10.2147/JPR.S551730 Alzheimer's & dementia IF: 04.400Volume 17, Issue 4No.102The impact of APOE ε4 on cognition in Brazilians with type 2 diabetes: exploring ethnicity effectsAPOE ε4对巴西2型糖尿病患者认知功能的影响：探索种族效应DOI: 10.1002/dad2.70231 JCEM case reportsVolume 4, Issue 1No.103Acute Autonomic Sensory Neuropathy Causing Severe Hyponatremia: A Rare Cause of Syndrome of Inappropriate Antidiuresis急性自主神经感觉神经病变引发严重低钠血症：抗利尿激素分泌不当综合征的一种罕见病因DOI: 10.1210/jcemcr/luaf299 Patient preference and adherence IF: 02.000Volume 19, Issue No.104Medication Adherence to Semaglutide versus Empagliflozin in Adults with Type 2 Diabetes: A Retrospective Observational Study in Saudi Arabia沙特阿拉伯2型成人糖尿病患者司美格鲁肽与恩格列净的用药依从性比较：一项回顾性观察研究DOI: 10.2147/PPA.S569096 Curēus IF: 01.300Volume 17, Issue 11No.105Temporal Trends in Cardiometabolic Control Among Canadian Adults: A Comparative Analysis of Hypertension and Diabetes Using the Canadian Health Measures Survey (CHMS) 2008-2019加拿大成人心血管代谢控制的时间趋势：基于加拿大健康测量调查（CHMS）2008-2019年高血压与糖尿病的比较分析DOI: 10.7759/cureus.97547 Curēus IF: 01.300Volume 17, Issue 11No.106Reversible Central Adrenal Insufficiency Without Identifiable Cause: A Diagnostic Challenge原因不明的可逆性中枢性肾上腺皮质功能减退症：一项诊断挑战DOI: 10.7759/cureus.97505 Curēus IF: 01.300Volume 17, Issue 11No.107Audit of Shoulder Dystocia Management and Outcomes at a Busy Hospital in the United Kingdom: A Comprehensive Analysis of Contemporary Practice英国某繁忙医院肩难产管理与结局的审计：当代实践的全面分析DOI: 10.7759/cureus.97528 Antimicrob Steward Healthc Epidemiol IF: 01.800Volume 5, Issue 1No.108How common? Exploring the prevalence and risk factors for Pseudomonas aeruginosa in diabetic foot infections among kidney transplant recipients肾移植受者糖尿病足部感染中铜绿假单胞菌的患病率及危险因素探讨DOI: 10.1017/ash.2025.10232 Journal of nutritional science IF: 02.000Volume 14, Issue No.109Palmitic acid reduces cytosolic potassium and induces IL-1β production in lipopolysaccharide-primed human macrophages棕榈酸降低细胞质钾并诱导脂多糖预激的人巨噬细胞产生IL-1βDOI: 10.1017/jns.2025.10053 OncoscienceVolume 12, Issue No.110Necrotizing fasciitis of the head and neck - clinical features, diagnostics, and management strategies头颈部坏死性筋膜炎：临床特征、诊断与管理策略DOI: 10.18632/oncoscience.639 Curēus IF: 01.300Volume 17, Issue 12No.111Management of Ankle Fractures: Does the Timing of Surgical Intervention Have an Impact on Patient Outcomes?踝关节骨折的管理：手术时机是否影响患者预后？DOI: 10.7759/cureus.99924 Frontiers in nutrition IF: 05.100Volume 12, Issue No.112Prognostic implications of serum ferritin levels in non-anemic women with stage 3 chronic kidney disease血清铁蛋白水平对非贫血女性3期慢性肾脏病患者的预后意义DOI: 10.3389/fnut.2025.1682003 Frontiers in immunology IF: 05.900Volume 16, Issue No.113Cross-talk between aging resilience pathways and autoimmunity onset衰老韧性通路与自身免疫发病的交互作用DOI: 10.3389/fimmu.2025.1712575 Immunotherapy advances IF: 04.900Volume 5, Issue 1No.114A phase 1 experimental medicine study of anti-CD3 monoclonal antibody in rheumatoid arthritis一项抗CD3单克隆抗体在类风湿关节炎中的1期实验医学研究DOI: 10.1093/immadv/ltaf034 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.115Six cases of ENPP1 pathogenic variants causing autosomal recessive hypophosphatemic rickets type 2 and generalized arterial calcification of infancyENPP1致病性变异导致常染色体隐性遗传性低磷性佝偻病2型和婴儿期全身性动脉钙化的六例报告DOI: 10.1093/jbmrpl/ziae174 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.116A case and review of fibroblast growth factor-23-mediated hypophosphatemic osteomalacia in the absence of pathogenic PHEX variants病例报告与综述：PHEX基因无致病性变异背景下成纤维细胞生长因子-23介导的低磷性骨软化症DOI: 10.1093/jbmrpl/ziae167 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.117Prevalence, predictors, and natural history of hypophosphatemia following iron infusion铁剂输注后低磷血症的患病率、预测因素及自然病程DOI: 10.1093/jbmrpl/ziaf014 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.118Hearing impairment in X-linked hypophosphatemia: a reviewX连锁低磷血症中的听力障碍：一项综述DOI: 10.1093/jbmrpl/ziaf062 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.119Patient and carer perceptions and acceptability of current management practices in paediatric X-linked hypophosphatemia treated with burosumab therapy布罗索尤单抗治疗的儿科X连锁低磷血症患者及照顾者对当前管理实践的看法与可接受性DOI: 10.1093/jbmrpl/ziaf033 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.120Hypophosphatemia across the lifespan贯穿生命周期的低磷血症DOI: 10.1093/jbmrpl/ziaf177 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.121A retrospective analysis of the prevalence of hypophosphatemia and hypocalcemia after intravenous iron polymaltose in the inpatient setting回顾性分析住院患者静脉注射铁蔗糖后低磷血症和低钙血症的患病率DOI: 10.1093/jbmrpl/ziaf103 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.122"Double trouble": the impact of iron infusion and antiresorptive therapy on calcium-phosphate homeostasis“双重打击”：静脉铁剂与抗骨吸收药物对钙磷稳态的影响DOI: 10.1093/jbmrpl/ziae177 JBMR plus IF: 02.400Volume 9, Issue Suppl 5No.123What is it like living with X-linked hypophosphatemia?: results from an Australian consumer survey与X连锁低磷性佝偻病共存是什么体验？——一项澳大利亚消费者调查结果DOI: 10.1093/jbmrpl/ziaf027 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.124Clinical Manifestations基线个体内认知变异预测八年后的认知障碍DOI: 10.1002/alz70857_100767 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.125Biomarkers生物标志物DOI: 10.1002/alz70856_099085 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.126Clinical Manifestations临床表现DOI: 10.1002/alz70857_102075 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 4No.127Dementia Care Research and Psychosocial Factors初级保健护士执业医师在痴呆症护理中的实践挑战与组织因素DOI: 10.1002/alz70858_103523 Am J Case Rep IF: 01.000Volume 26, Issue No.128The Silent Surge: A Case of Rhabdomyolysis-Induced Hypercalcemia无声的激增：一例横纹肌溶解诱发的高钙血症DOI: 10.12659/AJCR.950626 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 4No.129Dementia Care Research and Psychosocial Factors痴呆症照护研究与社会心理因素DOI: 10.1002/alz70858_102442 BMC infectious diseases IF: 03.000Volume 25, Issue 1No.130The use of recommended vaccinations among patients with chronic diseases in relation to attitudes toward vaccination and anxiety levels慢性病患者推荐疫苗接种的使用情况及其与接种态度和焦虑水平的关系DOI: 10.1186/s12879-025-12169-7 BMC research notes IF: 01.700Ahead of Print.No.131Prevalence and multimodal factors associated with impaired kidney function among persons with and without HIV in a routine clinic setting: a cross-sectional study常规门诊环境中HIV感染与非感染人群肾功能受损的患病率及其相关多模态因素：一项横断面研究DOI: 10.1186/s13104-025-07624-2 bioRxivVolume 2025, Issue No.132Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35线粒体来源的PEP通过SLC25A35调控甘油脂合成DOI: 10.64898/2025.12.12.693842 bioRxivVolume 2025, Issue No.133Dapagliflozin mitigates hypoxia-induced metabolic stress, kidney tubular cell death and fibrosis达格列净缓解缺氧诱导的代谢应激、肾小管细胞死亡及纤维化DOI: 10.64898/2025.12.13.693777 Medical journal of MalaysiaVolume 80, Issue Suppl 6No.134Interrupted sitting at work can alter postprandial glucose, triglycerides and non-esterified fatty acids (NEFA)工作中断坐姿可改变餐后血糖、甘油三酯和非酯化脂肪酸（NEFA）水平https://pubmed.ncbi.nlm.nih.gov/41447008 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 2No.135Biomarkers利用自动机器学习和脑成像生物标志物预测痴呆风险因素DOI: 10.1002/alz70856_100888 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 3No.136Clinical Manifestations临床研究DOI: 10.1002/alz70857_101552 Obesity science & practice IF: 01.900Volume 11, Issue 6No.137Exploring Methods of Adjusting VO(2)max for Body Size to Estimate Aerobic Capacity in People Presenting for Metabolic and Bariatric Surgery探索调整最大摄氧量以评估减重手术患者有氧能力的方法DOI: 10.1002/osp4.70105 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.138Extracellular vesicle miR-425-5p promotes visceral fat reduction via DACT1 suppression in SGLT2i-treated diabetes细胞外囊泡miR-425-5p通过抑制DACT1促进SGLT2i治疗的糖尿病患者内脏脂肪减少DOI: 10.3389/fendo.2025.1725625 Urology case reports IF: 00.400Volume 64, Issue No.139Adrenal hemangioma: A rare incidental tumor managed with laparoscopic partial adrenalectomy肾上腺血管瘤：一例经腹腔镜肾上腺部分切除术治疗的罕见偶发瘤DOI: 10.1016/j.eucr.2025.103305 Frontiers in public health IF: 03.400Volume 13, Issue No.140Premenstrual symptoms and associated factors in female students in Saudi Arabia: a cross-sectional study沙特女学生经前期症状及相关因素：一项横断面研究DOI: 10.3389/fpubh.2025.1699948 Curēus IF: 01.300Volume 17, Issue 11No.141Clinical Experience With Nasogastric Tube Placement Using a Biologically Transparent Illumination System in Critically Ill Patients在危重患者中使用生物透光系统放置鼻胃管的临床经验DOI: 10.7759/cureus.97545 Frontiers in surgery IF: 01.800Volume 12, Issue No.142Robotic hormonal and autonomic modulation for type 2 diabetes: ileal interposition and hepatic sympathectomy机器人辅助激素与自主神经调节治疗2型糖尿病：回肠间置术联合肝交感神经切除术DOI: 10.3389/fsurg.2025.1657656 bioRxivVolume 2025, Issue No.143Phenotypic Screening Coupled with AI-Driven Target Deconvolution Identifies α-Terthienyl as a Dual DPP-IV/HSD17β13 Modulator with Efficacy in a Mouse Model of MASLD表型筛选联合人工智能驱动的靶点解析鉴定α-三噻吩为DPP-IV/HSD17β13双重调节剂并在小鼠MASLD模型中显示有效性DOI: 10.64898/2025.12.12.693988 bioRxivVolume 2025, Issue No.144An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feedingAgRP神经元在限时进食中维持体温的关键作用DOI: 10.64898/2025.12.16.694714 bioRxivVolume 2025, Issue No.145Mitochondrial control of fuel switching via carnitine biosynthesis通过肉碱生物合成实现的线粒体燃料转换控制DOI: 10.64898/2025.12.16.694762 Obesity pillarsVolume 17, Issue No.146Applicability of the New Zealand-eating behavior questionnaire to predict weight loss responses to naltrexone/bupropion: a proof-of-concept trial新西兰饮食行为问卷在预测纳曲酮/安非他酮体重减轻反应中的应用：一项概念验证试验DOI: 10.1016/j.obpill.2025.100240 South Asian journal of cancer IF: 00.600Volume 14, Issue 3No.147Early Endocrine and Metabolic Complications in Childhood Cancer Survivors-Experience from a Tertiary Care Pediatric Oncology Center in South India儿童癌症幸存者的早期内分泌与代谢并发症——来自南印度一家三级儿科肿瘤中心的经验DOI: 10.1055/s-0044-1792004 Frontiers in nutrition IF: 05.100Volume 12, Issue No.148A cross-cultural study of unwillingness to consume insects in Croatia, Lithuania, Portugal, Romania, and Mexico克罗地亚、立陶宛、葡萄牙、罗马尼亚和墨西哥关于不愿食用昆虫的跨文化研究DOI: 10.3389/fnut.2025.1699378 Case reports in gastroenterology IF: 00.600Volume 20, Issue 1No.149Long-Term Remission of Peritoneal Lymphangiomatosis with Sirolimus Therapy: A Case Report with 8-Year Follow-Up西罗莫司治疗腹膜淋巴管瘤病获得长期缓解：一例随访8年的病例报告DOI: 10.1159/000549801 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.150Basic Science and Pathogenesis双侧颈动脉钙化手术损害tau蛋白病小鼠模型的空间学习与记忆DOI: 10.1002/alz70855_106829 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 5No.151Drug Development钠-葡萄糖协同转运蛋白2抑制剂与心力衰竭合并糖尿病患者痴呆风险的研究DOI: 10.1002/alz70859_096860 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.152Basic Science and Pathogenesis在认知正常的脑中，海马胰岛素抵抗随年龄增长而增加，但在阿尔茨海默病痴呆中则随年龄增长而降低，并与AD病理呈正相关DOI: 10.1002/alz70855_106242 Curēus IF: 01.300Volume 17, Issue 11No.153Successful Treatment of Exploding Head Syndrome With Ketamine使用氯胺酮成功治疗爆炸头综合征DOI: 10.7759/cureus.97558 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 4No.154Dementia Care Research and Psychosocial Factors阿尔茨海默病痴呆相关激越：加拿大公共药物计划索赔数据（2003-2023年）中的治疗模式DOI: 10.1002/alz70858_098409 Frontiers in digital health IF: 03.800Volume 7, Issue No.155Uncovering bias and variability in how large language models attribute cardiovascular risk揭示大型语言模型心血管风险评估中的偏倚与变异性DOI: 10.3389/fdgth.2025.1710594 Alzheimer's & dementia IF: 11.100Volume 21, Issue Suppl 1No.156Basic Science and Pathogenesis可调节风险因素对不同人群阿尔茨海默病遗传风险的调节作用DOI: 10.1002/alz70855_107321 The FASEB journal : IF: 04.200Volume 40, Issue 1No.157Glucose Induces DNMT1/IMPDH2-Dependent Metabolic Memory in Endothelial Cells Upon Reprograming Nucleotide Metabolism葡萄糖通过DNMT1/IMPDH2依赖性机制重编程核苷酸代谢诱导内皮细胞代谢记忆DOI: 10.1096/fj.202502260RR BMC ophthalmology IF: 01.700Ahead of Print.No.158Multimodal artificial intelligence in retinal vascular and neovascular macular diseases: a systematic review of diagnostic and prognostic applications多模态人工智能在视网膜血管及新生血管性黄斑疾病中的应用：一项关于诊断与预后价值的系统评价DOI: 10.1186/s12886-025-04561-3 Circ Arrhythm Electrophysiol IF: 09.800Ahead of Print.No.159Impact of GLP-1 Receptor Agonist Therapy on Atrial Fibrillation Recurrence After Catheter Ablation in Obese Patients: A Real-World Data AnalysisGLP-1受体激动剂治疗对导管消融术后肥胖患者房颤复发的影响：一项真实世界数据分析DOI: 10.1161/CIRCEP.125.014101 Curēus IF: 01.300Volume 17, Issue 12No.160Glucagon-Like Peptide-1 Receptor Agonists in Plastic Surgery: Perioperative Considerations and Safety Protocols胰高血糖素样肽-1受体激动剂在整形外科的应用：围术期考量与安全方案DOI: 10.7759/cureus.99865 Ther Adv Psychopharmacol IF: 04.000Volume 15, Issue No.161Effects of glucagon-like peptide-1 receptor agonists on psychiatric disorders: a systematic review胰高血糖素样肽-1受体激动剂对精神疾病影响的系统评价DOI: 10.1177/20451253251396304 149 Diabetes Mellitus(DM) 糖尿病 57 Obesity 肥胖症 36 Insulin 胰岛素 17 Type 2 diabetes mellitus(T2DM) 2型糖尿病 9 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 9 Diabetic Retinopathy 糖尿病视网膜病 7 Metabolic Syndrome 代谢综合征 6 Metformin 二甲双胍 6 Semaglutide 司美格鲁肽 4 Liraglutide 利拉鲁肽 4 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 3 Dapagliflozin 达格列净 3 Hypoglycemic Agents 降糖药 3 Diabetic Foot 糖尿病足 3 Diabetic Neuropathies 糖尿病性神经病变 2 Gabapentin 加巴喷丁 2 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 2 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 2 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 2 Dulaglutide 度拉糖肽 1 Exenatide 艾塞那肽 1 Lixisenatide 利司那肽 1 Empagliflozin 恩格列净 1 Sotagliflozin 索格列净 1 Diabetic acidosis 糖尿病性酸中毒 1 Type 1 diabetes mellitus(T1DM) 1型糖尿病 1 Sitagliptin 西他列汀 1 Tirzepatide 替尔泊肽 1 Pregabalin 普瑞巴林 编辑：韩玉莲 审校：韩玉莲