Bupropion Hydrochloride/Naltrexone Hydrochloride

Contrave, the #1 branded oral non-GLP-1 weight loss medication* is now available to self-funded employers through Peek BRENTWOOD, Tenn., April 1, 2026 /PRNewswire/ -- Currax Pharmaceuticals LLC ("Currax"), a specialty pharmaceutical company and manufacturer of the #1 branded oral non-GLP-1 weight loss medication CONTRAVE® (naltrexone HCl/bupropion HCl)*, today announced expanded access to CONTRAVE® through PeekDirect, in partnership with Peek Healthcare Technologies, Inc. ("Peek"). PeekDirect is Peek's access model that connects employers and patients directly with pharmaceutical manufacturers to deliver transparent, upfront pricing at the point of prescription. In partnership with Professional Arts Specialty Pharmacy, dispensing pharmacy partner for both PeekDirect and Currax, the program provides manufacturers with a seamless patient experience and a turnkey distribution channel. Traditional, rebate-driven access models distort pricing and are overly complicated. PeekDirect cuts through the complexity, eliminates the middlemen and delivers predictable pricing and lower out-of-pocket costs. With no change to how physicians prescribe or how patients access their medications – PeekDirect is a simpler path to affordability. "Expanding patient access is central to who we are and how we operate at Currax," said George Hampton, President and CEO of Currax. "Our partnership with PeekDirect removes unnecessary intermediaries and gives patients straightforward access to our FDA-approved obesity treatment. Our priority is to ensure cost savings reach patients." "Peek is about bringing transparency and affordability into the healthcare system," said Michael Navin, CEO of Peek. "Our partnership with Currax is another important step forward, expanding access to therapies through a more transparent and efficient distribution model. Employers can now offer meaningful savings, while patients gain direct access to the medications they need without unnecessary barriers." *Based on the number of prescriptions filled for brand name weight-loss drugs in the IQVIA database in November 2025. About Peek Peek is a healthcare technology company that connects biopharma, employers, and patients with affordable, direct access to specialty and high-cost medicines. By eliminating unnecessary intermediaries, Peek helps organizations deliver better benefits while lowering costs and improving access. For more information, visit peekmeds.com. About Currax Currax is a specialty pharmaceutical company that pursues transformative therapies for chronic conditions like obesity. Combining innovative advancements with compassionate care, Currax delivers therapies that are designed to inspire hope and offer life-changing outcomes. Currax's flagship product, CONTRAVE® (naltrexone HCl/bupropion HCl), reflects the company's commitment to provide therapies that offer unmatched versatility and utility. Learn more at About CONTRAVE: CONTRAVE®, is an extended-release fixed dose combination of naltrexone and bupropion (naltrexone HCl/bupropion HCl) indicated in combination with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term in adults with obesity or who are overweight in the presence of at least one weight-related comorbid condition. For full Prescribing Information, including BOXED WARNING and Medication Guide, please visit . What is CONTRAVE? CONTRAVE is a prescription weight-loss medicine that may help adults with obesity, or some adults who are overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. CONTRAVE should be used with a reduced-calorie diet and increased physical activity. It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke. CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation). Please see Full Prescribing Information , including Medication Guide , for CONTRAVE. IMPORTANT SAFETY INFORMATION CONTRAVE can cause serious side effects including: Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment. While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes. Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping. CONTRAVE is not approved for use in children under the age of 18. Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE. Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. CONTRAVE may cause serious side effects, including: Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away. Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death. Get emergency medical help right away if you take opioids and you: have trouble breathing become very drowsy with slowed breathing have slow, shallow breathing feel faint, very dizzy, confused, or have unusual symptoms Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery. Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing. Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE. Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem. Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again. Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk. Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE. The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088 . Media Contact [email protected] SOURCE Currax Pharmaceuticals LLC 21% more press release views with Request a Demo

BRENTWOOD, Tenn., March 25, 2026 /PRNewswire/ -- Currax Pharmaceuticals LLC ("Currax") today recognizes the publication of the Joint Expert Guidance Statement on the Pharmacologic Management of Adults with Overweight or Obesity, developed by The Obesity Society (TOS), the Obesity Medicine Association (OMA), and the Obesity Action Coalition (OAC). The guidance, developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework and informed by both clinical experts and individuals with lived experience, provides evidence‑based recommendations for the use of FDA‑approved obesity medications in adults with overweight or obesity and related complications. Among its conclusions, the multidisciplinary panel issued its highest recommendation (strong) for several pharmacologic options, including the fixed-dose extended-release combination of bupropion–naltrexone, tirzepatide and semaglutide, based on the totality of available evidence and consideration of patient‑important outcomes such as quality of life, safety, feasibility, and long‑term disease management. The guidance also issued a strong recommendation for continuation of obesity medications for weight‑loss maintenance, reinforcing obesity's recognition as a chronic condition requiring ongoing care. The statement reflects an evolving approach to obesity treatment that prioritizes person‑centered outcomes, including quality of life and management of obesity‑related complications, alongside weight reduction. Weight loss was not identified as the sole critical outcome, underscoring the broader goals of treatment beyond the scale. The guidance further emphasizes that the potential impact of advances in obesity pharmacotherapy will remain limited unless persistent barriers—including insurance exclusions, affordability challenges, stigma, and gaps in education—are addressed. Currax supports efforts across the clinical and scientific community to advance evidence‑based, patient‑centered obesity care and recognizes the role of clear, methodologically rigorous guidance in supporting informed clinical decision‑making and access to appropriate treatment. About Currax Currax is a specialty pharmaceutical company that pursues transformative therapies for chronic conditions like obesity. Combining innovative advancements with compassionate care, Currax delivers therapies that are designed to inspire hope and offer life-changing outcomes. Currax's flagship product, CONTRAVE® (naltrexone HCl/bupropion HCl), reflects the company's commitment to provide therapies that offer unmatched versatility and utility. Learn more at About CONTRAVE: CONTRAVE®, is an extended-release fixed dose combination of naltrexone and bupropion (naltrexone HCl/bupropion HCl) indicated in combination with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term in adults with obesity or who are overweight in the presence of at least one weight-related comorbid condition. For full Prescribing Information, including BOXED WARNING and Medication Guide, please visit . What is CONTRAVE? CONTRAVE is a prescription weight-loss medicine that may help adults with obesity, or some adults who are overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. CONTRAVE should be used with a reduced-calorie diet and increased physical activity. It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke. CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation). Please see Full Prescribing Information , including Medication Guide , for CONTRAVE. IMPORTANT SAFETY INFORMATION CONTRAVE can cause serious side effects including: Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment. While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes. Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping. CONTRAVE is not approved for use in children under the age of 18. Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE. Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. CONTRAVE may cause serious side effects, including: Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away. Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death. Get emergency medical help right away if you take opioids and you: have trouble breathing become very drowsy with slowed breathing have slow, shallow breathing feel faint, very dizzy, confused, or have unusual symptoms Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery. Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing. Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE. Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem. Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again. Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk. Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE. The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088. Media Contact SVP Corporate Development and Strategy, Hope Mueller [email protected] SOURCE Currax Pharmaceuticals LLC 21% more press release views with Request a Demo