The increasing cases of peripheral neuropathic pain, rise in screening for diabetic neuropathic pain among diabetics, increase in the geriatric population, and launch of new approved drugs, among other reasons are likely to fuel the growth of the peripheral neuropathic pain market size during the forecast period (2024–2034).
LAS VEGAS, Aug. 28, 2024 /PRNewswire/ --DelveInsight's
Peripheral Neuropathic Pain Market Insights report includes a comprehensive understanding of current treatment practices, peripheral neuropathic pain emerging drugs, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan].
Key Takeaways from the Peripheral Neuropathic Pain Market Report
According to DelveInsight's analysis, the market size for peripheral neuropathic pain was found to be ~
USD 12 billion in the 7MM in 2023.
The United States accounts for the largest market size of PNP in comparison to EU4 (Germany, Spain, Italy, France), the United Kingdom, and Japan.
The total cases of peripheral neuropathic pain in the 7MM were approximately
60 million cases in 2023, which are expected to increase during the study period (2020–2034).
Leading peripheral neuropathic pain companies such as
Lexicon Pharmaceuticals, Merz Therapeutics, Apurano Pharmaceuticals, Vertex Pharmaceuticals, WEX Pharmaceuticals, Scilex Holding Company, and others are developing novel peripheral neuropathic pain drugs that can be available in the peripheral neuropathic pain market in the coming years.
The promising peripheral neuropathic pain therapies in the pipeline include
LX9211, XEOMIN (incobotulinumtoxinA), Adezunap (AP707), Suzetrigine (VX-548), HALNEURON (Tetrodotoxin or TTX), SEMDEXA (SP-102), and others.
Compared to all the emerging therapies,
LX9211 and SEMDEXA are expected to become the market leader, having a major influence on the peripheral neuropathic pain market of the 7MM by 2034.
In
November 2023, Lexicon Pharmaceuticals announced that it has enrolled the first patient in PROGRESS (A Phase IIb, dose-ranging, randomized, double-blind, placebo-controlled, parallel-group, multicenter study with an open-label extension in patients with diabetic peripheral neuropathic pain) studying LX9211.
Discover which therapies are expected to grab the major peripheral neuropathic pain market share @
Peripheral Neuropathic Pain Market Report
Peripheral Neuropathic Pain Overview
Peripheral neuropathies refer to conditions affecting peripheral nerve cells and fibers, arising from a variety of underlying causes. These nerves include the cranial nerves, spinal nerve roots and ganglia, nerve trunks and divisions, and the autonomic nervous system nerves. Peripheral neuropathies can be classified in several ways, such as mononeuropathies, multifocal neuropathies, and polyneuropathies. Mononeuropathy involves damage to a single nerve, while multiple mononeuropathy affects two or more nerves in different locations. Polyneuropathy typically impacts many or most nerves.
The diversity of symptoms associated with peripheral neuropathy allows for the identification of distinct clinical phenotypes, which is important for guiding the diagnostic process. Nerve conduction studies are crucial for determining the phenotype and assessing severity. Additional diagnostic tools, such as laboratory tests, genetic testing, cerebrospinal fluid examination, nerve imaging, and nerve biopsy, may be useful in specific clinical situations.
Peripheral Neuropathic Pain Epidemiology Segmentation
The peripheral neuropathic pain epidemiology section provides insights into the historical and current peripheral neuropathic pain patient pool and forecasted trends for the 7MM. It helps recognize the causes of current and forecasted patient trends by exploring numerous studies and views of key opinion leaders.
The peripheral neuropathic pain market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:
Total Cases of PNP
Type-specific Cases of PNP
Treated Cases of PNP
Peripheral Neuropathic Pain Treatment Market
The treatment of peripheral neuropathic pain depends on the underlying cause and the severity of symptoms. Initial management typically involves conservative measures, including medications such as NSAIDs, acetaminophen, and, in more severe cases, opioids. For radicular symptoms, neuroleptic agents may be used, and systemic steroids are sometimes prescribed for acute low back pain. Nonpharmacological treatments like physical therapy, acupuncture, chiropractic manipulation, and traction are also employed, though their effectiveness is debated.
Interventional procedures, such as epidural steroid injections and percutaneous disc decompression, are commonly performed, while surgical options like decompression and spinal fusion are considered for cases that do not respond to other treatments. Pain management for PNP also includes the use of drugs such as NSAIDs, anticonvulsants, and antidepressants, with specific medications like
QUTENZA, NUCYNTA ER, and TARLIGE approved for certain patient groups.
TARLIGE (mirogabalin besylate) is an oral gabapentinoid developed by Daiichi Sankyo to treat peripheral neuropathic pain (PNP), including diabetic PNP and postherpetic neuralgia. In January 2019, Daiichi Sankyo announced that TARLIGE received approval for marketing in Japan for PNP treatment, offering patients in Japan a new therapeutic option for managing PNP.
NUCYNTA ER (tapentadol) is an opioid agonist available as an extended-release film-coated tablet for oral use. It is prescribed for managing neuropathic pain related to diabetic peripheral neuropathy (DPN). In August 2012, the US FDA approved a sNDA for NUCYNTA ER, allowing it to be used as an oral analgesic taken twice daily to manage neuropathic pain in adults with DPN when ongoing, around-the-clock opioid treatment is required for a prolonged duration.
The QUTENZA (capsaicin) 8% topical system delivers capsaicin through a localized dermal application. Capsaicin acts as an agonist for the TRPV1 receptor. In July 2020, Grünenthal's US subsidiary, Averitas Pharma, obtained FDA approval for the QUTENZA 8% patch to treat neuropathic pain related to diabetic peripheral neuropathy in the feet of adults.
To know more about peripheral neuropathic pain treatment guidelines, visit @
Peripheral Neuropathic Pain Management
Peripheral Neuropathic Pain Pipeline Therapies and Key Companies
LX9211: Lexicon Pharmaceuticals
XEOMIN (IncobotulinumtoxinA): Merz Therapeutics
Adezunap (AP707): Apurano Pharmaceuticals
Suzetrigine (VX-548): Vertex Pharmaceuticals
HALNEURON (Tetrodotoxin or TTX): WEX Pharmaceuticals
SEMDEXA (SP-102): Scilex Holding Company
Discover more about peripheral neuropathic pain drugs in development @
Peripheral Neuropathic Pain Clinical Trials
Peripheral Neuropathic Pain Market Dynamics
The peripheral neuropathic pain market dynamics are expected to change in the coming years. Emerging disease-modifying therapies for
diabetic neuropathy, CIPN, and LSR are gaining attention due to the
growing prevalence of cancer,
increased chemotherapy usage, and the
large patient pool in need of pain management. The
lack of disease-modifying treatment options in the current landscape, which relies solely on symptomatic relief, highlights the market potential for these therapies. Recent developmental activities targeting novel pathways, such as
adapter-associated kinase 1 (AAK1) and the
Nav1.8 voltage-gated sodium channel, aim to provide opioid-free pain relief, which could lead to a high uptake and the ability to charge a premium price.
Furthermore, potential therapies are being investigated for the treatment of peripheral neuropathic pain, and it is safe to predict that the treatment space will significantly impact the peripheral neuropathic pain market during the forecast period. Moreover, the
anticipated introduction of emerging therapies with improved efficacy and a further
improvement in the diagnosis rate are expected to drive the growth of the peripheral neuropathic pain market in the 7MM.
However several factors may impede the growth of the peripheral neuropathic pain market. The
management of DPN is challenging due to the persistent and severe nature of neuropathic pain, which is frequently ineffectively treated and
negatively impacts the quality of life, further complicated by pharmacogenetic and genetic variations in patients; additionally, while improving glycemic control in
Type-2 diabetes remains uncertain, the availability of
low-cost generics in the treatment landscape may significantly hamper the
uptake of emerging therapies, increasing the
burden and associated health costs.
Moreover, peripheral neuropathic pain treatment poses a
significant economic burden and disrupts patients' overall well-being and QOL. Furthermore, peripheral neuropathic pain market growth may be offset by
failures and discontinuation of emerging therapies,
unaffordable pricing,
market access and reimbursement issues, and a
shortage of healthcare specialists. In addition, the
undiagnosed, unreported cases and the unawareness about the disease may also impact peripheral neuropathic pain market growth.
Scope of the
Peripheral Neuropathic Pain
Market Report
Therapeutic Assessment: Peripheral Neuropathic Pain current marketed and emerging therapies
Peripheral Neuropathic Pain
Market Dynamics: Key Market Forecast Assumptions of Emerging Peripheral Neuropathic Pain Drugs and Market Outlook
Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
Unmet Needs, KOL's views, Analyst's views, Peripheral Neuropathic Pain Market Access and Reimbursement
Download the report to understand which factors are driving peripheral neuropathic pain market trends @
Peripheral Neuropathic Pain Market Trends
Table of Contents
Related Reports
Peripheral Neuropathic Pain Epidemiology Forecast
Peripheral Neuropathic Pain Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology as well as the Peripheral Neuropathic Pain epidemiology trends.
Peripheral Neuropathic Pain Pipeline
Peripheral Neuropathic Pain Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key Peripheral Neuropathic Pain companies, including
Haisco Pharmaceutical Group, GlaxoSmithKline, Algiax Pharmaceuticals, Apurano Pharmaceuticals GmbH, Eli Lilly and Company, Shanghai SIMR Biotechnology, Lexicon Pharmaceuticals, among others.
Diabetic Neuropathy Market
Diabetic Neuropathy Market Insights, Epidemiology, and Market Forecast
– 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key diabetic neuropathy companies, including
Novo Nordisk, Ionis Pharmaceuticals, Pfizer, Regeneron, NeuroMetrix, among others.
Diabetic Neuropathy Pipeline
Diabetic Neuropathy Pipeline Insight
– 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key diabetic neuropathy companies, including
Goldfinch Bio, Novartis, Serodus, CURACLE, Daiichi Sankyo, NeuroBo Pharmaceuticals, Dong-A Pharmaceutical
, among others.
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve
.
Contact Us
Shruti Thakur
[email protected]
+14699457679
Logo:
SOURCE DelveInsight Business Research, LLP
