Acetaminophen/Hydrocodone Bitartrate

Collectively, SiteOne shareholders could receive as much as $1 billion from the deal, according to Lilly.\n Eli Lilly is expanding its efforts to advance next-generation pain medications. The Big Pharma has penned a deal to acquire SiteOne Therapeutics, primarily for a non-opioid pain asset ready to enter phase 2 trials.Collectively, SiteOne shareholders could receive as much as $1 billion from the deal, Lilly said in a May 27 release, which includes an upfront payment, plus additional biobucks tied to certain milestones.Lilly’s sights are set on STC-004, a sodium channel inhibitor made to block NaV1.8, an ion channel primarily found in the peripheral nervous system and involved in pain sensation.\"The global burden of chronic pain continues to increase and an effective non-opioid treatment remains elusive,\" Mark Mintun, M.D., Lilly’s vice president of neuroscience R&D, said in the release. \"Lilly is eager to continue the development of STC-004 with the outstanding SiteOne team as part of our efforts to advance novel, addiction-free pain therapies.”SiteOne recently tested out STC-004 in a phase 1 trial, finding that a once-daily dose of the drug candidate was well-absorbed and well-tolerated, while also improving pain tolerance, according to a Feb. 4 release.The Bay Area biotech closed a $100 million series C fundraise led by Novo Holdings at the end of last year, with a goal of using the money to advance an early pipeline of pain candidates. In addition to NaV1.8, the company is also exploring other ion channel modulators, such as NaV1.7. Other NaV1.8 inhibitors have hit bumps in the road to replacing opioids. Vertex Pharmaceuticals, a biopharma long on the hunt for non-opioid pain relievers, dropped a pair of NaV1.8-targeting assets back in 2020, and then years later revealed a different inhibitor beat placebo at relieving pain in two phase 3 trials but failed to best the opioid Vicodin.Lilly previously entered a next-gen pain partnership with Pfizer, teaming up with the fellow pharma giant to develop nerve growth factor inhibitor tanezumab. However, the partners ultimately dumped tanezumab after regulators from the FDA and European Medicines Agency rejected it. The candidate had shown the ability to reduce pain in patients with osteoarthritis, but faced concerns over a link to joint damage.

注：本文不构成任何投资意见和建议，以官方/公司公告为准；本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及），不代表平台立场。任何文章转载需要得到授权。5月21日，宜昌人福药业的3类仿制药氢可酮布洛芬片获批上市，视同通过一致性评价，为国内首仿。氢可酮布洛芬片是由具有中枢镇痛作用的阿片类药物氢可酮与具有外周作用的抗炎镇痛药布洛芬组成的复方制剂，用于缓解急性疼痛，在替代治疗（例如非阿片类药物）不足、需要使用阿片类药物治疗情况下使用。布洛氢可酮片有两个规格，重酒石酸氢可酮5mg/布洛芬200mg、重酒石酸氢可酮7.5mg/布洛芬200mg，公司于2014年申报临床并于2016年获批，2022年11月提交上市申请，2025年5月获批上市，历时近11年。宜昌人福药业该项目累计投入约2000万元。据药监局官网信息，目前国内尚无氢可酮布洛芬片进口和国产厂家销售由于氢可酮使用的广泛性和便捷性，FDA认为它是导致阿片药物滥用和误用罪魁祸首，于是便出台了各种政策来控制。2014年FDA限制了氢可酮的处方权限。目前，市场上所有含有氢可酮的速释剂均为复方制剂（一般与对乙酰氨基酚或布洛芬复合），纯氢可酮制剂只有缓释剂（2014年FDA批准上市，商品名Zohydro ZR）。据摩熵医药销售数据库显示，布洛芬和氨酚氢可酮（对乙酰氨基酚/氢可酮复合制剂）2023年全国医院（全终端）销售额分别为53.61亿元和2474万元；2024上半年销售额分别为26.81亿元和1143万元。截图来源：摩熵医药全国医院（全终端）销售数据库小结人福医药几乎独揽了以芬太尼系列为代表的中高端麻醉镇痛药的全部市场，并占据总体麻醉镇痛药市场规模的50%以上，被称之为“麻药之王”。其中瑞芬太尼和舒芬太尼占据了公司半壁江山。另外一款大单品则是，强效阿片类药物盐酸氢吗啡酮注射液，此外，2024年1月，盐酸氢吗啡酮缓释片（适用于治疗成人重度疼痛）上市，进一步扩充了公司镇痛管线。凭借公司在镇痛领域的多年布局，氢可酮布洛芬片能够快速打开市场。END本文为原创文章，转载请留言获取授权近期热门资源获取数据透视：中药创新药、经典验方、改良型新药、同名同方的申报、获批、销售情况-2025042023H2-2024H1中国药品分析报告-2025042024年中国1类新药靶点白皮书-202503中国AI医疗健康企业创新发展百强榜单-202502解码护肤抗衰：消费偏好洞察与市场格局分析-2025022024年FDA批准上市的新药分析报告-2025012024年NMPA批准上市的新药分析报告-2025012024年医保谈判及市场分析报告-2025.012024年中国医疗健康投融资全景洞察报告-202501小分子化药白皮书（上）-2025012024医美注射材料市场发展分析报告-202412中国放射性药物产业白皮书-202410近期更多摩熵咨询热门报告，识别下方二维码领取联系我们，体验摩熵医药更多专业服务会议合作园区服务数据库咨询定制服务媒体合作点击上方图片，即可开启摩熵化学数据查询点击阅读原文，申请摩熵医药企业版免费试用！