预约演示
更新于：2026-01-17
Pregabalin
普瑞巴林
更新于：2026-01-17
概要
基本信息
简介普瑞巴林，商品名为 Lyrica®，是一种众所周知的抗惊厥药物，已在各种疾病的治疗中找到立足之地。 这些病症包括但不限于焦虑症、癫痫和神经痛。普瑞巴林的作用机制包括阻断 CACNA2D1、CACNA2D2钙通道，从而有效地治疗这些疾病。Upjohn Co. 早在 2004 年就在欧盟获得了普瑞巴林的医疗用途批准，并已在市场上应用。普瑞巴林的适应症主要针对神经性疼痛病症如纤维肌痛，与其他抗惊厥药物联合用于治疗部分发作性癫痫。由于普瑞巴林可最大限度地减少伴随症状，因此可以使用普瑞巴林来控制这些病症。 因此，普瑞巴林是治疗慢性疼痛和神经系统疾病的重要措施。 |
药物类型 小分子化药 |
别名 LYRICA CR、CI-1008、GLA5PR + [11] |
作用方式 阻滞剂 |
作用机制 CACNA2D1阻滞剂(电压门控性钙通道α2/δ亚基-1阻滞剂)、CACNA2D2阻滞剂(电压门控性钙通道α2/δ亚基-2阻滞剂) |
非在研适应症 |
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
登录后查看时间轴
结构/序列
分子式C8H17NO2 |
InChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-N |
CAS号148553-50-8 |
关联
1,037
项与 普瑞巴林 相关的临床试验NCT07288528
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough (FORTITUDE)
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory assessment of potential synergy in combining these interventions, and the long-term outcomes of these treatments in patients with refractory or unexplained chronic cough.
开始日期2026-04-01 |
申办/合作机构 |
CTRI/2025/03/081851
Comparing the effect of Virtual Reality and Pregabalin on Neuropathic pain over only Pregabalin in Traumatic Spinal Cord Injury: A Randomized Controlled Trial - NIL
开始日期2026-02-09 |
申办/合作机构- |
NCT07344467
Effect of Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery: A Prospective, Randomized Controlled Trial
This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.
开始日期2026-01-26 |
申办/合作机构 |
100 项与 普瑞巴林 相关的临床结果
登录后查看更多信息
100 项与 普瑞巴林 相关的转化医学
登录后查看更多信息
100 项与 普瑞巴林 相关的专利（医药）
登录后查看更多信息
5,599
项与 普瑞巴林 相关的文献（医药）2026-12-31·COPD-Journal of Chronic Obstructive Pulmonary Disease
Prescribing Patterns of Gabapentinoids in Patients with Chronic Obstructive Pulmonary Disorder
Article
作者: Bullock, Reece ; Dimit, Alexandra ; Patel, Manysha ; Englehart, Anika ; King, Olivia ; Soric, Mate Michael ; Mara, Nita ; Bole, Kelly ; Vergara, Mollie ; Moqbl, Amgad ; Skory, Brandon
In 2019, the U.S. Food and Drug Administration (FDA) issued a warning regarding the risk of serious respiratory depression in patients using gabapentin or pregabalin who have respiratory risk factors, including those with chronic obstructive pulmonary disorder (COPD). With the overall prescribing of gabapentinoids continuing to grow, there is the potential for inappropriate prescribing in this patient population. Data from the National Ambulatory Medical Care Survey (NAMCS) from 2013 to 2018, with the exception of 2017, was used to assess prevalence and predictors of gabapentinoid prescribing in patients with COPD. The data consists of 1,131 unweighted visits, representing approximately 53.6 million ambulatory care visits nationally. Of these visits, 146 patients (10.8%) with a COPD diagnosis were also prescribed a gabapentinoid, which represents more than a million office visits annually when weighted. Patients with an increased risk of receiving gabapentinoids were those with concomitant diabetes mellitus, concurrent opioid use, and those currently using tobacco. Due to increased risk of serious respiratory depression caused by gabapentinoids, prescribers should take caution when prescribing to individuals with COPD and other respiratory risk factors. Based on the reviewed prescribing patterns, more education is needed to inform providers about the risks associated with concomitant COPD and gabapentinoid use.
2026-03-01·BEHAVIOURAL BRAIN RESEARCH
Neurobehavioral and reinforcing effects of pregabalin in mice
Article
作者: Vodovar, Dominique ; Mégarbane, Bruno ; Callebert, Jacques ; Dufayet, Laurene ; Benturquia, Nadia
Pregabalin misuse is increasing, but its psychostimulant and rewarding properties remain unclear, especially regarding sex differences and interactions with opioids. The objectives of this study are to investigate pregabalin's behavioral and neurochemical effects in male and female mice, including its impact on cognition, social interaction, reinforcement, and cross-sensitization with morphine. CD-1 mice received pregabalin (30-90 mg/kg, i.p.) acutely or for 5 days. Locomotor activity, Y-maze performance, social behavior, and conditioned place preference (CPP) were assessed. Brain monoamine levels were quantified by HPLC. A D1 dopamine receptor antagonist (SCH 23390) was used to explore dopaminergic involvement. Morphine CPP was tested after pregabalin pretreatment. Results showed that in male mice, acute pregabalin induced transient hyperlocomotion and rewarding effects in CPP test, both associated with increased dopamine in the prefrontal cortex and striatum. No psychostimulant or reinforcing effects were observed in female mice. Pregabalin had no impact on memory or general social behavior, though a subset of males displayed aggression, coinciding with elevated serotonin and norepinephrine. Repeated pregabalin dosing produced tolerance without sensitization. Blocking D1 receptors abolished pregabalin-induced CPP. Importantly, pregabalin pretreatment enhanced morphine-induced CPP, suggesting cross-sensitization. Conclusions indicate that pregabalin exerts sex-specific stimulant and rewarding effects in mice, driven by dopaminergic signaling. Its ability to potentiate morphine's rewarding properties raises concern about abuse potential, particularly in opioid-exposed individuals. These findings highlight the need to consider sex as a biological variable when assessing the addictive risk of pregabalin.
2026-02-01·JOURNAL OF ARTHROPLASTY
Analgesic Efficacy and Side Effects of Low-Dose Pregabalin As a Modern Multimodal Agent for Postoperative Pain Control After Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Controlled Trial
Article
作者: Kukreja, Seksan ; Pinitchanon, Punnawit ; Boontanapibul, Krit ; Pinsornsak, Piya
BACKGROUND:
Pregabalin is an essential component of contemporary multimodal analgesic strategies for managing postoperative pain after total knee arthroplasty (TKA). The current recommendation is a daily dosage of 150 to 300 mg for 14 days postoperatively. Reported side effects include dizziness and sedation. Our study aimed to investigate the analgesic efficacy and side effects of low-dose pregabalin (75 mg) compared with the recommended 150 mg dose.
METHODS:
We conducted a double-blinded, randomized controlled trial in patients undergoing unilateral primary TKA to compare the efficacy of postoperative pregabalin at 75 versus 150 mg daily for 14 days. All patients received intraoperative corticosteroids, spinal anesthesia, adductor canal block, pericapsular injection, and other standardized medications. The primary outcome was pain, assessed using the visual analog scale at rest and during motion at 24, 48 hours, and at two, six, and 12 weeks postoperatively. Secondary outcomes included morphine consumption, adverse events, time to ambulation, knee flexion, Knee Society Scores, the Two-Minute Walking Test, and the Timed Up-and-Go Test.
RESULTS:
Our results revealed no statistically significant difference in visual analog scale scores between the 75 and 150 mg groups at various time points up to 12 weeks postsurgery. However, the 75 mg group exhibited substantially lower incidences of dizziness (17 versus 61% in the 150 mg group, P < 0.001) and faster time to ambulation (27 ± four versus 30 ± four hours in the 150 mg group, P < 0.001). Other outcome measures showed no notable variances between the two groups.
CONCLUSIONS:
A 75 mg dosage of pregabalin for 14 days post-TKA provided pain control similar to 150 mg, with additional benefits of faster ambulation and reduced dizziness. Therefore, we advocate for the use of 75 mg pregabalin as part of a contemporary multimodal analgesic regimen for postoperative pain management after TKA, particularly in the growing trend of outpatient TKA.
LEVEL OF EVIDENCE:
Therapeutic level I.
511
项与 普瑞巴林 相关的新闻（医药）2026-01-14
·今日头条
低PE+长调整+绩优滞涨！创新药4只洼地股1月待爆发（2026.1.14）
2026年创新药板块迎来“政策底+业绩底+估值底”三重共振，BD出海交易持续爆发、医保政策优化加码、临床数据密集读出，板块龙头率先启动行情，但资金正加速向“低价+低估值+长蓄力”的滞涨标的切换。以下4只核心标的均满足股价偏低、市盈率处于历史低位、业绩稳健且调整充分的特质，基于2025年最新财报及权威行业数据筛选，经交叉复核确保真实可靠，具备随时爆发的潜力。
一、浙江医药（600216）
- 业绩表现：2025年三季度实现归母净利润同比增长8.3%，扣非净利润同比增长11.2%，核心业务原料药（VA/VE）盈利稳定，抗真菌创新药艾沙康唑胶囊持续放量，贡献增量收入；创新药研发投入同比提升15%，管线覆盖肿瘤、抗感染等刚需领域，毛利率维持在52%以上，盈利韧性突出。
- 调整周期：近12个月股价在12-18元区间横盘震荡，较2023年高点回调超35%，期间成交量逐步萎缩，筹码换手充分，当前市盈率（TTM）仅10.6倍，显著低于创新药行业平均30倍，估值处于历史15%分位。
- 爆发逻辑：仿创结合龙头，国际化布局成熟，美国ANDA认证品种超50个，海外收入占比达38%；1类创新药RX108（新型抗菌药）进入Ⅲ期临床，针对多重耐药菌感染，填补国内治疗空白，2026年有望提交NDA；受益于CDMO行业高景气，原料药业务与创新药协同增长，估值修复空间巨大。
二、普洛药业（000739）
- 业绩表现：2025年三季度净利润同比增长12.5%，小分子CDMO业务收入同比增长28%，服务全球多家知名药企，订单排期至2026年下半年；自研创新药方面，抗癫痫1类新药普瑞巴林缓释胶囊已上市销售，肿瘤管线PLB1004进入Ⅱ期临床，业绩增长确定性强。
- 调整周期：近8个月股价从22元高位持续回调，最大跌幅超30%，当前处于低位震荡阶段，抛压释放彻底，市盈率（TTM）22倍，低于CXO+创新药板块平均估值45%，估值安全边际充足 。
- 爆发逻辑：CDMO业务受益于全球创新药研发投入增长，产能持续扩张支撑订单兑现；创新药管线聚焦神经、肿瘤领域，与CDMO业务形成协同，研发风险分散；作为机构低配标的，2025Q3基金持仓比例仅1.2%，后续加仓空间充足，叠加板块高低切换趋势，补涨潜力突出。
三、华海药业（600521）
- 业绩表现：2025年三季度营收同比增长7.6%，归母净利润同比增长9.8%，抗高血压创新药阿利沙坦酯销售额突破15亿元，成为核心盈利支柱；精神类、心血管类仿制药在美市场份额稳步提升，海外收入占比超40%，盈利结构持续优化；研发投入占比达8.5%，管线储备18个1类创新药。
- 调整周期：近15个月股价在15-20元区间横盘整理，较2021年历史高点跌幅超50%，调整时间充分，筹码集中度逐步提升，当前市盈率（TTM）25倍，低于创新药国际化赛道平均35倍估值。
- 爆发逻辑：仿创结合+国际化双轮驱动，PD-1双抗管线进入临床阶段，存在对外授权预期；受益于美国仿制药市场集中度提升，ANDA品种放量带动业绩增长；医保动态调整缩短创新药纳入周期，阿利沙坦酯有望进一步扩大院内覆盖，2026年业绩增速有望提速至15%以上。
四、恩华药业（002262）
- 业绩表现：2025年三季度净利润同比增长13.2%，中枢神经药物（麻醉、精神类）龙头地位稳固，产品市占率持续提升；创新药布局成瘾性疾病、神经退行性疾病等细分赛道，1类新药NH102（抗抑郁药）进入Ⅲ期临床，Ⅱ期数据显示疗效优于同类产品，毛利率维持在68%的高位水平。
- 调整周期：近10个月股价在10-14元区间低位震荡，调整幅度超25%，期间未跟随板块前期炒作，估值处于历史低位，市盈率（TTM）28倍，显著低于细分赛道平均45倍估值。
- 爆发逻辑：中枢神经赛道壁垒高、竞争格局优，创新药填补国内未满足需求；老龄化加剧带动精神类药物需求增长，叠加政策支持精神卫生服务体系建设，行业景气度持续提升；公司现金流健康，研发投入持续加码，2026年有望迎来创新药收获期，估值与业绩双升可期。
风险提示
本文基于公司公告、行业报告及公开市场数据整理，仅为标的梳理，不构成任何投资建议。创新药领域存在研发失败、临床进展不及预期、医保谈判降价超预期、国际化进度受阻等风险；部分标的业绩增长依赖单一业务，可能面临行业竞争加剧压力，投资者需结合基本面理性决策。
财报临床3期临床2期
2026-01-13
一、疼痛过敏的核心机制与病理基础
1.1 定义与分类框架
疼痛过敏是机体对疼痛刺激敏感性异常增强的病理状态，核心表现为痛觉过敏（有害刺激反应增强）和异常性疼痛（无害刺激引发疼痛），是慢性疼痛的核心特征。国际疼痛研究协会（IASP）推荐NeuPSIG、Schafer等分类算法，为精准诊断提供标准化工具，其中中枢敏化疼痛需满足疼痛与损伤不成比例、弥漫性疼痛伴敏化等核心标准。
1.2 主要疼痛类型的机制差异
神经病理性疼痛：由神经损伤引发，外周敏化是起始环节——电压门控钠通道（NaV1.7/1.8/1.9）上调，炎症介质（前列腺素、ATP等）激活伤害感受器；中枢敏化是维持核心，NMDA受体激活导致脊髓背角神经元兴奋性增强，胶质细胞释放的BDNF进一步削弱GABA抑制作用。神经炎症贯穿全程，小胶质细胞活化是关键驱动因素。
炎症性疼痛：组织损伤释放的PGE2是核心介质，既敏化外周感受器，又通过阻断GlyR α-3受体增强中枢兴奋性。TRPV1通道在其中起关键作用，炎症因子通过胞内通路调控其表达与功能，免疫细胞则通过释放促痛/镇痛介质调控疼痛进程。
纤维肌痛：以中枢敏化为核心，脊髓抑制系统（GABA）功能减弱、小胶质细胞活化导致痛觉信号放大。线粒体功能障碍（辅酶Q10缺乏）引发氧化应激，神经炎症激活先天免疫，下行镇痛通路抑制与兴奋性通路增强的失衡共同导致症状群。
二、近十年疼痛治疗药物的临床突破
2.1 国际重磅新药进展
2025年成为疼痛治疗突破年：FDA批准Journavx（suzetrigine），作为20年来首个新机制急性疼痛镇痛药，其选择性抑制NaV1.8通道，外周作用模式避免阿片类成瘾风险，在腹部整形、拇外翻术后试验中镇痛效果显著优于安慰剂，且不良反应轻微（瘙痒、肌痉挛为主）。同年获批的Tonmya（盐酸环苯扎林舌下片），是15年来首个纤维肌痛新药，透粘膜吸收减少代谢物毒性，III期试验中疼痛评分降低幅度显著优于安慰剂（-1.9 vs -1.5），局部反应短暂可控。
阿片类创新药方面，2020年FDA批准G蛋白偏向性μ受体激动剂Oliceridine（Olinvo®），通过独特受体结合特性降低呼吸抑制风险；非甾体抗炎药领域，Anjeso（美洛昔康注射剂）为术后疼痛提供新选择。
2.2 中国与欧洲审批动态
中国NMPA在2025年密集获批多款新药：恩华药业盐酸羟考酮缓释片（视同过评）、江宁造“普坦宁™”（美洛昔康注射液II）、恒瑞医药泰吉利定注射液（骨科术后疼痛）、海思科思舒静（腹部术后疼痛），覆盖阿片类与非阿片类领域。恩华药业引进的TRV130（G蛋白偏向性激动剂）已于2023年上市，填补急性疼痛治疗空白。
EMA在2015年批准芬太尼透皮系统Ionsys用于术后疼痛，2025年兽医药品委员会对犬骨关节炎长效镇痛药的积极意见，为人类相关药物研发提供参考。
2.3 治疗指南的核心更新
2025年NeuPSIG神经病理性疼痛指南提出三级治疗体系：一线用TCAs、SNRIs和α2δ配体；二线推荐8%辣椒素贴片等外用药；三线谨慎使用肉毒毒素、rTMS及阿片类。AAP儿童疼痛指南强调非药物/非阿片优先，ADA牙科疼痛指南将NSAIDs单药或联合对乙酰氨基酚列为一线，反映全球“减阿片”趋势。
三、药物研发的靶点创新与技术突破
3.1 经典靶点的精准开发
钠离子通道：NaV1.7是遗传性疼痛的关键靶点，PF-05089771（选择性抑制剂）已完成12项I期研究，CNV-1014802获FDA孤儿药认定用于三叉神经痛；NaV1.8抑制剂Dexpramipexole在炎症性、神经性疼痛模型中口服/局部给药均有效。
α2δ配体：普瑞巴林通过结合钙通道α2δ亚基调节突触前钙电流，其镇痛效果与该亚基结合直接相关，不依赖GABA受体，是神经病理性疼痛一线药物。
3.2 新兴靶点的临床转化
P2X3受体：拜耳Eliapixant对P2X3同源受体高度选择性，避免前代药物副作用，II期试验评估其在膀胱过度活动症、糖尿病神经痛等疾病中的疗效，为超敏性疾病提供新方向。
TRPV1通道：辣椒素类似物capsazepine可逆转豚鼠机械性痛觉过敏，但存在物种差异，新一代调节剂正通过结构优化提升临床适用性。
3.3 多靶点与技术创新策略
双靶点药物Cebranopadol同时激活NOP和μ受体，IIa期试验显示强效镇痛，避免单一受体激动剂缺陷。NMDA受体拮抗剂氯胺酮/艾司氯胺酮在神经病理性疼痛、纤维肌痛中疗效确切，艾司氯胺酮镇痛活性是外消旋体的2倍，耐受性更优。
技术层面，患者特异性iPSC衍生感觉神经元可模拟NaV1.7突变患者的电生理特征，预测药物反应；AI算法通过分析临床试验数据加速药物筛选，XGBoost算法在慢性疼痛检测中F1分数达0.92。
四、基础研究向临床转化的关键进展
4.1 精准医学的实践应用
NaV1.7药物基因组学研究显示，4名IEM患者的iPSC神经元对阻滞剂反应差异显著，其中1例体外无应答者临床疗效亦不佳，验证了个体化模型的预测价值。药物基因组学检测在反复治疗失败患者中应用明确，104例患者中仅2.9%为全基因正常代谢表型，支持靶向用药。
4.2 生物标志物的临床价值
慢性疼痛生物标志物体系涵盖PROs、脑成像、QST及生物学指标：CRPS患者IL-6/TNF-α升高，P物质在急性期与痛敏相关；脑脊液Aβ1-42、ptau181与慢性疼痛伴认知受损相关；EEG的α/β波功率变化为疼痛评估提供客观依据。
4.3 基因与细胞治疗前景
rAAV载体通过鞘内注射靶向初级感觉神经元，表达脑啡肽、GABA等镇痛分子，在啮齿动物模型中实现长期镇痛。间充质干细胞（MSC）分泌TGF-β1抑制神经炎症，单次鞘内注射可缓解神经病理性疼痛数周；调节性T细胞过继转移亦显示镇痛潜力。
五、挑战与未来趋势
5.1 核心障碍
疼痛机制异质性导致生物标志物缺乏，临床试验安慰剂反应率高达30-40%；阿片类成瘾风险与非阿片类药物副作用（NSAIDs心血管毒性、抗抑郁药抗胆碱能反应）限制应用；创新药开发成本高，长期治疗可及性不足。
5.2 发展方向
技术驱动：QSPainRelief平台通过数学建模优化药物组合；VR结合AI提供个性化认知干预；神经调节技术（rTMS、SCS）获指南推荐，成为药物替代方案。
治疗模式革新：植物来源的RTX单次鞘内注射使癌痛患者疼痛强度降低38%；低剂量纳曲酮（LDN）通过调节免疫缓解纤维肌痛；多模式治疗（外周药物+中枢调节+非药物干预）成为主流策略。
结论
近十年疼痛领域实现机制认知与药物开发双重突破：Journavx、Tonmya等新药填补治疗空白，NaV1.7、P2X3等靶点推动精准治疗。技术层面，iPSC、AI、基因编辑加速转化进程，生物标志物体系逐步完善。尽管机制异质性、临床试验设计等挑战仍存，但个性化治疗、多模式干预与技术创新的融合，正推动疼痛治疗从“一刀切”迈向精准化时代，为全球数亿患者带来新希望。
2026-01-13
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至01月13日15点59分，近期共有 433 本期刊发布了 850 篇文章，其中糖尿病相关的文章共 318 篇，覆盖 37 个领域的内容。中国专家参与发表的文章有 55 篇。今日，影响因子最高的文章刊登在 Signal transduction and targeted therapy (IF: 52.700) 期刊上。
今日头条
Headlines
01 Int J Med Inform IF: 04.100 临床医生对电子病历在糖尿病门诊护理中应用的视角：一项定性研究
Wang, Wenyong, Samadbeik, Mahnaz, Puri, Gaurav, McLeod, Donald S A, Lobo, Elton, Duong, Tuan, etc.
近日，一项定性研究深入探讨了临床医生在糖尿病门诊护理中使用电子病历（EMR）的真实体验与看法。该研究由Wenyong Wang等共同完成，旨在填补EMR在特定门诊场景下影响证据的空白。
研究在澳大利亚昆士兰州一家大都市糖尿病服务中心开展，采用了焦点小组的形式，共有22名来自不同岗位的临床医生参与，包括医生、护士和专职医疗人员。数据分析结合了“Quintuple Aim”（五重目标）框架和“技术接受模型”，以期全面评估EMR对医疗质量、效率及医护人员体验的多维度影响。
研究发现，临床医生对EMR的感受呈现显著的“双面性”。积极的一面是，医生们普遍认为，EMR提高了工作效率，使得获取患者历史信息、检验结果和既往处方变得前所未有的便捷。在安全性方面，系统内置的处方审核与警示功能，被认为有效降低了用药错误的风险。
然而，临床医生也提及系统存在导航复杂、界面不够直观、偶发技术故障等问题，影响了使用的流畅度。更为突出的是“警报疲劳”，即系统过多的弹窗和提醒，可能导致重要信息被忽略，反而增加了认知负荷。此外，如何在系统中进行恰当、高效的文档记录，以及如何应对患者因知晓EMR存在而产生的不同期望，都让临床人员感到压力。研究还指出，初期庞杂而缺乏针对性的培训，也加重了医护人员的适应负担。
综合这些正反两方面的体验，研究得出结论：在当前糖尿病门诊场景下，EMR确实在提升信息可及性、工作流程效率和医疗安全方面发挥了关键作用。但同时，其现有的设计逻辑和部署方式，也给临床医生的工作体验和幸福感带来了不容忽视的负面影响。研究人员特别指出，像糖尿病这类需要长期、综合数据管理的慢性病，其复杂的护理需求（例如血糖趋势的整合分析）可能尚未被通用型EMR系统完美支持。
基于这些发现，研究团队强调，EMR的部署与优化应被视为一项持续的质量改进工程，而非一次性技术安装。他们呼吁，未来的努力方向应包括大力改善系统可用性、提供分角色、场景化的精准培训、确保技术基础设施的稳定可靠，并且必须让一线临床医生深度参与到系统的优化设计中。未来的研究应解决可用性挑战，增强整合，并确保临床医生和患者的观点共同引领数字健康转型。
本文由 韩玉莲 编辑
扫描二维码查看源文
Int J Med Inform | Ahead of Print.
10.1016/j.ijmedinf.2026.106275
02 Diabetes, obesity & metabolism IF: 05.700 糖皮质激素在1型糖尿病中应用的系统综述：血糖效应与临床管理策略
Katz, Alexandra, Shulkin, Aidan, Housni, Asmaa, Roy-Fleming, Amélie, Rabasa-Lhoret, Rémi, Yale, Jean-Francois, etc.
近日，一项Alexandra Katz等学者发表的系统综述，深入探讨了糖皮质激素（GCs）在1型糖尿病患者中的应用及其对血糖管理带来的挑战。
糖皮质激素是治疗炎症和自身免疫性疾病的常用药物，但其一个众所周知的副作用是诱发高血糖。对于依赖胰岛素治疗的1型糖尿病患者而言，如何在GCs治疗期间调整胰岛素剂量以维持血糖稳定，是一个复杂的临床难题，且目前缺乏清晰的管理建议。
这项系统性研究检索了截至2025年8月的多个医学数据库，共纳入了22项相关研究，涉及总计368名成年1型糖尿病患者。分析结果表明，无论采用何种剂型、剂量或给药途径，GCs治疗均与明显的血糖波动和胰岛素需求量上升密切相关。无论是GCs口服或静脉给药，胰岛素需求都需要在基线水平上大幅增加，部分研究中增幅高达70%。
研究进一步揭示了不同临床情境下的差异。在妊娠期使用产前糖皮质激素时，通过结构化的皮下或静脉胰岛素输注方案进行管理，效果较为理想。而对于关节内注射等局部给药的GCs，其引起的血糖升高可能延迟出现，但持续时间较长，需要更长时间的严密血糖监测。
随着糖尿病管理技术的进步，自动胰岛素输注系统（AID）在此场景下的作用也受到了关注。现有证据提示，AID系统可能有助于减轻GCs引发的血糖升高幅度，但系统仍然需要使用者根据情况进行主动干预和调整。
基于现有证据，综述指出，GCs治疗确实会显著扰乱1型糖尿病患者的血糖稳定性。其影响程度和模式取决于药物本身特性、给药方式以及患者个体因素和具体的临床背景。目前，最为切实可行的管理策略是采取主动、个体化的方法，即根据所用GCs的药代动力学特点，预先规划和调整胰岛素剂量，并辅以频繁的血糖监测或连续血糖监测技术的使用。
研究者最后强调，为了优化1型糖尿病患者的合并用药管理，未来仍需开展更多研究，以建立基于高质量证据的临床指南，并进一步阐明像AID这样的先进技术在应对GCs相关高血糖中的确切角色和最佳使用方案。
本文由 韩玉莲 编辑
扫描二维码查看源文
Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70465
03 Journal of obesity IF: 03.900 促进超重或肥胖人群运动依从性的干预措施有效性：一项系统综述
Rodrigues, Matheus de Sena Anchieta, Atanasio, Lívia de Melo, Dos Santos, Isis Kelly, da Silva, José Carlos Gomes, Cabral, Breno Guilherme de Araujo Tinoco, Dantas, Paulo Moreira Silva, etc.
近日，一项发表在Journal of Obesity上的系统综述研究，为我们理解如何帮助超重或肥胖人群坚持运动提供了新的证据。该研究系统评估了旨在提升该人群运动依从性的各种干预措施，揭示了可能有效的策略，同时也指出了当前研究领域的局限。
这项研究由Rodrigues等人完成，他们检索了包括MEDLINE、Embase在内的五大数据库，最终纳入了17项符合标准的随机对照试验。这些研究覆盖了美国、加拿大、澳大利亚、欧洲等多个地区，干预时长从12周到2年不等，旨在探索不同方法对运动坚持情况的影响。
分析结果显示，在多种干预形式中，**以小组形式开展的运动项目**以及**由受过培训的专业人员直接监督的干预**，显示出与更高运动依从性相关的积极趋势。这意味着，在集体环境中锻炼或获得专业的现场指导，可能更有利于超重或肥胖个体克服障碍，将运动计划坚持下去。
而干预措施是否结合了饮食指导或心理行为策略、运动的频率、每次的时长和强度如何，以及参与者的体重，在这些研究中都未发现它们与运动依从性水平存在稳定的关联。
大多数研究存在中度至高度的偏倚风险，这意味着其结果可能受到各种混杂因素或设计缺陷的影响，从而限制了当前证据的可靠性。
因此，尽管本综述指出了集体与有监督的干预措施可有效提高超重或肥胖成年人的锻炼依从性，但研究者强调乐未来在该领域进行更严谨、设计更精良的随机对照试验的必要性。未来的研究需要更清晰地描述干预细节，采用更客观、一致的依从性测量方法，并关注如何维持长期的运动参与，尤其是在干预数月之后依从性可能下降的关键时期。
本文由 韩玉莲 编辑
扫描二维码查看源文
Journal of obesity | Volume 2025, Issue
10.1155/jobe/4164477
中国发表（55）
China
J Health Popul Nutr IF: 02.800Ahead of Print.No.01Time-restricted eating in overweight and obese adults: an evidence summary and clinical recommendations限时进食在超重和肥胖成人中的应用：一项证据总结与临床建议DOI: 10.1186/s41043-025-01221-6
BMC musculoskeletal disorders IF: 02.400Ahead of Print.No.02Does metabolically healthy obesity increase the risk of knee and hand osteoarthritis? A population-based cohort study代谢健康型肥胖是否会增加膝与手骨关节炎风险？一项基于人群的队列研究DOI: 10.1186/s12891-026-09495-5
BMC pediatrics IF: 02.000Ahead of Print.No.03Association between dietary folate intake and obesity in children and adolescents: a cross-sectional NHANES study饮食中叶酸摄入量与儿童青少年肥胖的关联：一项横断面NHANES研究DOI: 10.1186/s12887-025-06490-y
Appl Microbiol Biotechnol IF: 04.300Ahead of Print.No.04Distinct oral and fecal microbiota composition in preschool children with overweight/obesity: a cross-sectional study学龄前超重/肥胖儿童存在独特的口腔和粪便微生物群组成：一项横断面研究DOI: 10.1007/s00253-025-13685-x
International journal of obesity IF: 03.800Ahead of Print.No.05Multidimensional risk impact of obesity on breast cancer incidence, treatment, and prognosis肥胖对乳腺癌发病率、治疗和预后的多维风险影响DOI: 10.1038/s41366-025-02008-9
Cellular signalling IF: 03.700Ahead of Print.No.06Role of CTRP9 in obesity-associated microglial dysregulation: Promoting lipophagy via the PI3K/AKT/FOXO1 signaling pathwayCTRP9在肥胖相关小胶质细胞失调中的作用：通过PI3K/AKT/FOXO1信号通路促进脂自噬DOI: 10.1016/j.cellsig.2026.112358
Acta clinica belgica : IF: 01.100Ahead of Print.No.07A comprehensive review and meta-analysis of relationship between age of onset or duration of type 2 diabetes and mortality involving more than 2.85 million patients涵盖超285万患者的大型综述与荟萃分析：全面评估2型糖尿病发病年龄或病程与死亡率的关系DOI: 10.1080/17843286.2026.2615091
Environmental research IF: 07.700Volume 291, Issue No.08Associations of concomitant exposure to outdoor light at night, air pollution, and greenness with metabolic syndrome: A cohort study in China夜间户外光、空气污染与绿地暴露与代谢综合征的关联性研究：一项中国队列研究DOI: 10.1016/j.envres.2025.123590
Biogerontology IF: 04.100Volume 27, Issue 1No.09FOXO: a key target in regulating aging and age-related diseasesFOXO：调控衰老与年龄相关疾病的关键靶点DOI: 10.1007/s10522-025-10380-2
European journal of pharmacology IF: 04.700Ahead of Print.No.10SIRT1-mediated YAP deacetylation suppresses myocardial hypertrophy in diabetic cardiomyopathySIRT1介导的YAP去乙酰化抑制糖尿病心肌病中的心肌肥大DOI: 10.1016/j.ejphar.2026.178538
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.11Association of triglyceride-glucose index with all-cause mortality in critically ill non-diabetic ischemic stroke: a retrospective cohort study based on the MIMIC-IV database甘油三酯-葡萄糖指数与危重非糖尿病缺血性卒中患者全因死亡率的关联：一项基于MIMIC-IV数据库的回顾性队列研究DOI: 10.1186/s12872-025-05458-1
BMC infectious diseases IF: 03.000Ahead of Print.No.12Correlation analysis between the prevalence of hyperuricemia and the triglyceride-glucose index in adult patients with brucellosis成人布鲁氏菌病患者高尿酸血症患病率与甘油三酯-葡萄糖指数的相关性分析DOI: 10.1186/s12879-026-12532-2
Eur J Med Res IF: 03.400Ahead of Print.No.13Modified cardiometabolic index outperforms conventional indices in discriminating relative muscle loss: a cross-sectional analysis of NHANES 2011-2018改良心脏代谢指数在鉴别相对肌肉减少方面优于传统指数：一项基于NHANES 2011-2018的横断面分析DOI: 10.1186/s40001-026-03879-y
Community dental health IF: 01.000Ahead of Print.No.14Effect of type 1 diabetes on oral lichen planus mediated by IL-101型糖尿病通过IL-10介导对口腔扁平苔藓的影响DOI: 10.1177/0265539X261416458
Yingyong shengtai xuebaoVolume 37, Issue 1No.15[Effects of γ-aminobutyric acid and chlorinated hemin composite coating on seed germination and seedling growth of Psathyrostachys juncea under drought and salt stresses]γ-氨基丁酸与氯化血红素复合包衣对新麦草种子萌发及幼苗生长在干旱与盐胁迫下的影响DOI: 10.13287/j.1001-9332.202601.011
NeuroImage IF: 04.500Volume 325, Issue No.16Aberrant thalamic GABA-network coupling as a neural signature of insomnia severity in major depressive disorder丘脑GABA-网络耦合异常作为重度抑郁症失眠严重程度的神经特征DOI: 10.1016/j.neuroimage.2025.121639
Current eye research IF: 02.000Ahead of Print.No.17Association Between Pancreatic β-Cell Function and Quantitative OCT Angiography Metrics in Patients with Type 2 Diabetes Without Clinical Diabetic Retinopathy2型糖尿病无临床视网膜病变患者胰腺β细胞功能与定量OCTA指标之间的关联DOI: 10.1080/02713683.2026.2612760
Cell & bioscience IF: 06.200Ahead of Print.No.18Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D miceGLP-1受体激动剂与嗜黏蛋白阿克曼氏菌Akk11联用减轻2型糖尿病小鼠肥胖并改善MASLDDOI: 10.1186/s13578-025-01525-4
Food & function IF: 05.400Volume 17, Issue 1No.19Pro-inflammatory and pro-oxidant diets and CKD risk across cardiovascular-kidney-metabolic syndrome stages: a multi-omics mediation analysis促炎与促氧化饮食在心血管-肾脏-代谢综合征各阶段与慢性肾病风险：一项多组学中介分析DOI: 10.1039/d5fo03952e
Food & function IF: 05.400Volume 17, Issue 1No.20Bifidobacterium animalis subsp. lactis Bbm-19 ameliorates insomnia by remodeling the gut microbiota and restoring γ-aminobutyric acid and serotonin signaling动物双歧杆菌乳亚种Bbm-19通过重塑肠道菌群及恢复γ-氨基丁酸与血清素信号改善失眠DOI: 10.1039/d5fo04374c
Circulation IF: 38.600Volume 153, Issue 2No.21Letter by Zhao Regarding Article, "Oral Semaglutide and Cardiovascular Outcomes in People With Type 2 Diabetes, According to SGLT2i Use: Prespecified Analyses of the SOUL Randomized Trial"Zhao的来函：关于文章“口服司美格鲁肽与2型糖尿病患者心血管结局：基于SGLT2i使用的SOUL随机试验预设分析”DOI: 10.1161/CIRCULATIONAHA.125.076451
J Asian Nat Prod Res IF: 01.300Ahead of Print.No.22Research on the effects and mechanisms of the Yiqi Huoxue Recipe in improving renal injury in diabetic nephropathy through the HIF-1 pathway基于HIF-1通路探讨益气活血方改善糖尿病肾病肾损伤的作用及机制研究DOI: 10.1080/10286020.2025.2602695
The FASEB journal : IF: 04.200Volume 40, Issue 2No.23C-X-C Motif Chemokine Ligand 3 as a Potential Biomarker for Diagnosis and Prognosis of Diabetic Kidney DiseaseC-X-C基序趋化因子配体3作为糖尿病肾脏病诊断和预后的潜在生物标志物DOI: 10.1096/fj.202502236R
GeroScience IF: 05.400Ahead of Print.No.24Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults社区老年人生命周期体型轨迹与脑氧代谢DOI: 10.1007/s11357-025-02082-x
Clin Transl Oncol IF: 02.500Ahead of Print.No.25Single-cell and spatial transcriptomics reveal mTOR-driven cellular fate of spindle cells and immune evasion in classic Kaposi's sarcoma单细胞与空间转录组学揭示经典型卡波西肉瘤中mTOR驱动的纺锤体细胞命运与免疫逃逸DOI: 10.1007/s12094-025-04063-0
Apoptosis IF: 08.100Volume 31, Issue 1No.26Propofol attenuates angiogenesis by activating endoplasmic reticulum stress to suppress TFAP2C-driven VEGFA transcription丙泊酚通过激活内质网应激抑制TFAP2C驱动的VEGFA转录来减弱血管生成DOI: 10.1007/s10495-025-02214-w
Cardiovascular Drugs and Therapy IF: 03.100Ahead of Print.No.27Empagliflozin Supplementation in Cardioplegic Solution Improves Donor Heart Preservation by Maintaining Mitochondrial Homeostasis在心脏停搏液中补充恩格列净通过维持线粒体稳态改善供体心脏保存DOI: 10.1007/s10557-026-07834-1
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.28The contested association between MASLD and osteoporosis: a narrative review of heterogeneous evidence and modifying factorsMASLD与骨质疏松的关联备受争议：一项关于异质性证据与修饰因子的叙述性综述DOI: 10.1007/s11657-025-01639-9
Advanced materials IF: 26.800Ahead of Print.No.29An AI-embedded, Wearable Dual Closed-Loop Insulin Delivery System for Precision Diabetes Management一种用于精准糖尿病管理的AI嵌入式可穿戴双闭环胰岛素输送系统DOI: 10.1002/adma.202514945
Advanced science IF: 14.100Ahead of Print.No.30HMGB2-RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat InfiltrationHMGB2-RAD21轴通过促进纤维/脂肪组细胞增殖调控脂肪浸润DOI: 10.1002/advs.202514363
World J Exp MedVolume 15, Issue 3No.31Systematic review and risk factor analysis of post-vitrectomy silicone oil migration to the central nervous system玻璃体切除术后硅油向中枢神经系统迁移的系统性综述和危险因素分析DOI: 10.5493/wjem.v15.i3.106429
Food Science and Biotechnology IF: 03.100Volume 35, Issue 1No.32Synergistic modulation of metabolic disorders by konjac glucomannan and Polygonatum cyrtonema Hua polysaccharides: integrated insights from in vitro digestion, gut microbiota, and hepatic metabolomics魔芋葡甘聚糖与黄精多糖协同调控代谢紊乱：来自体外消化、肠道菌群和肝脏代谢组学的综合见解DOI: 10.1007/s10068-025-02015-6
Food Science and Biotechnology IF: 03.100Volume 35, Issue 1No.33Active ingredients, nutrition values and health-promoting effects of aboveground parts of rhubarb: a review大黄地上部分的活性成分、营养价值与健康促进功效综述DOI: 10.1007/s10068-025-01919-7
Food science & nutrition IF: 03.800Volume 14, Issue 1No.34Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism川陈皮素通过促进有氧代谢改善D-半乳糖诱导衰老小鼠的骨骼肌性能DOI: 10.1002/fsn3.71416
Clinical case reports IF: 00.600Volume 14, Issue 1No.35Central Diabetes Insipidus in Suprasellar Germ Cell Tumor Paradoxically Presenting With Oliguria鞍上生殖细胞瘤所致中枢性尿崩症矛盾性表现为少尿DOI: 10.1002/ccr3.71832
Quant Imaging Med Surg IF: 02.300Volume 16, Issue 1No.36A novel computed tomography-based algorithm for the quantitative identification of lumbar spine-localized trabecular bone loss in patients with type 2 diabetes mellitus基于新型计算机断层扫描算法定量识别2型糖尿病患者腰椎局部骨小梁骨丢失DOI: 10.21037/qims-2025-1312
Journal of clinical nursing IF: 03.500Ahead of Print.No.37Comment on 'Dyadic Patterns of Patient and Caregiver Engagement in Type 2 Diabetes Mellitus Care': Innovative Directions Beyond Static Profiles评《Dyadic Patterns of Patient and Caregiver Engagement in Type 2 Diabetes Mellitus Care》：超越静态特征的创新方向DOI: 10.1111/jocn.70208
Analytical methods IF: 02.600Ahead of Print.No.38A highly sensitive LC-MS/MS method for quantification of AB-38b in rat plasma, liver and kidney tissues: application to a pharmacokinetic study用于定量大鼠血浆、肝及肾组织中AB-38b的高灵敏度LC-MS/MS方法：在药代动力学研究中的应用DOI: 10.1039/d5ay01136a
World J Exp MedVolume 15, Issue 3No.39PI3K/AKT/GSK3β regulatory axis in bone mesenchymal stem cells initiates diabetic myocardial infarction via miR-142-3p骨髓间充质干细胞通过miR-142-3p调控的PI3K/AKT/GSK3β通路影响糖尿病心肌梗死DOI: 10.5493/wjem.v15.i3.103948
Digital health IF: 03.300Volume 12, Issue No.40Development of an explainable machine learning model for predicting poststroke anxiety: A multicenter study using Shapley Additive Explanations and nomogram visualization基于SHAP和列线图可视化的可解释机器学习模型预测卒中后焦虑：一项多中心研究DOI: 10.1177/20552076251412575
Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.41Contiguous orbital inflammation from paranasal sinus abnormalities in etiology of thyroid-associated ophthalmopathy鼻旁窦异常引起的毗邻性眼眶炎症在甲状腺相关眼病病因学中的作用DOI: 10.18240/ijo.2026.01.13
Chin J Cancer Res IF: 06.300Volume 37, Issue 6No.42Leukemia epidemiology in China: Burden, trends, and determinants in the 21st century中国白血病流行病学：21世纪的疾病负担、趋势与决定因素DOI: 10.21147/j.issn.1000-9604.2025.06.03
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.43Body mass index mediates the association between serum fibroblast growth factor-19 and diabetes体重指数介导血清成纤维细胞生长因子-19与糖尿病之间的关联DOI: 10.1007/s40200-025-01850-y
Annals of medicine IF: 04.300Volume 58, Issue 1No.44Letter to the Editor regarding: 'Global epidemiology of diabetes and prediabetes in lean or non-obese patients with NAFLD: a systematic review and meta-analysis'关于瘦型或非肥胖NAFLD患者中糖尿病与前驱糖尿病全球流行病学特征的系统综述和荟萃分析DOI: 10.1080/07853890.2026.2614829
Artif Cells Nanomed Biotechnol IF: 04.500Volume 54, Issue 1No.45Detection of pathogenic novel intronic splicing variants in the KIDINS220 gene causes motor developmental delay在KIDINS220基因中检测到致病性的新型内含子剪接变异导致运动发育迟缓DOI: 10.1080/21691401.2026.2612914
The FASEB journal : IF: 04.200Volume 40, Issue 2No.46Gpx4 Deletion-Mediated Macrophage Ferroptosis Alleviates Obesity-Associated Insulin Resistance巨噬细胞Gpx4缺失介导的铁死亡缓解肥胖相关的胰岛素抵抗DOI: 10.1096/fj.202503596R
Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.47Ranibizumab on optic disc perfusion in central retinal vein occlusion雷珠单抗对视网膜中央静脉阻塞患者视盘血流灌注的影响DOI: 10.18240/ijo.2026.01.10
Food science & nutrition IF: 03.800Volume 14, Issue 1No.48Astragalus membranaceus-Salvia miltiorrhiza Decoction Ameliorates Metabolic Syndrome and Gut Microbiota Dysbiosis Induced by High-Fat Diet: A Comparative Study黄芪-丹参煎剂改善高脂饮食诱导的代谢综合征与肠道菌群失调：一项比较研究DOI: 10.1002/fsn3.71436
RC IF: 01.300Volume 26, Issue 12No.49The Relationship Between the C-reactive Protein-Triglyceride Glucose Index and the Risk of Coronary Heart Disease Alongside the Severity of Coronary Artery Stenosis in Older Adults With Different Levels of Glucose Metabolism: A Real-World Retrospective Clinical StudyC反应蛋白-甘油三酯葡萄糖指数与不同糖代谢水平老年人群冠心病风险及冠状动脉狭窄严重程度的关系：一项真实世界回顾性临床研究DOI: 10.31083/RCM45886
Journal of diabetes research IF: 03.400Volume 2026, Issue No.50Effect of Nordic Walking on Anthropometrics, Glycemia, and Lipid Profile in Adults With Prediabetes or Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials北欧式健走对糖尿病前期或糖尿病患者人体测量学指标、血糖及血脂的影响：随机对照试验的系统综述与Meta分析DOI: 10.1155/jdr/5886930
Transl Androl Urol IF: 01.700Volume 14, Issue 12No.51Associations of different insulin resistance indices with the erectile dysfunction incidence: a cross-sectional analysis of the NHANES 2001-2004不同胰岛素抵抗指数与勃起功能障碍发病率的关联：基于NHANES 2001-2004的横断面分析DOI: 10.21037/tau-2025-665
Transl Androl Urol IF: 01.700Volume 14, Issue 12No.52Exploring the association between the ZJU index and overactive bladder: a cross-sectional study based on NHANES 2011-2018探索ZJU指数与膀胱过度活动症之间的关联：一项基于NHANES 2011-2018的横断面研究DOI: 10.21037/tau-2025-557
Autophagy reportsVolume 5, Issue 1No.53Glycophagy: molecular mechanisms, regulatory signals, and disease associations糖噬：分子机制、调控信号与疾病关联DOI: 10.1080/27694127.2025.2595375
Food science & nutrition IF: 03.800Volume 14, Issue 1No.54Probiotic Supplementation With Bifidobacterium longum Subsp. Longum BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial补充益生菌Bifidobacterium longum subsp. longum BL21改善2型糖尿病患者血糖控制并调节肠道菌群：一项随机对照试验DOI: 10.1002/fsn3.71437
J Gastrointest Oncol IF: 02.000Volume 16, Issue 6No.55Survival outcomes of patients after liver transplantation for patients with hepatocellular carcinoma exceeding the Hangzhou criteria超出Hangzhou标准的肝细胞癌患者肝移植后的生存结局DOI: 10.21037/jgo-2025-aw-864
其他发布内容（260）
More Published Articles
Int J Biol Macromol IF: 08.500Ahead of Print.No.01Exploring molecular interactions of drugs in different biologically active solvents: A comprehensive review for safe and efficient drug delivery systems探索药物在不同生物活性溶剂中的分子相互作用：安全高效药物递送系统的综合评述DOI: 10.1016/j.ijbiomac.2026.150197
BMC nutrition IF: 02.200Ahead of Print.No.02Vitamin D status and cardiometabolic risk factors among hypertensive and normotensive adults: a hospital-based cross-sectional study in Nepal高血压与血压正常成人的维生素D状况及心脏代谢危险因素：尼泊尔的一项医院横断面研究DOI: 10.1186/s40795-026-01247-x
BMC surgery IF: 01.800Ahead of Print.No.03Psoriasis outcomes following metabolic bariatric surgery - a systematic review of the literature代谢减重手术后银屑病转归——文献系统综述DOI: 10.1186/s12893-026-03502-1
Obesity surgery IF: 03.100Ahead of Print.No.04Mortality and Causes of Death After Metabolic Bariatric Surgery in Older Patients老年患者减重手术后的死亡率及死因分析DOI: 10.1007/s11695-026-08487-7
Pharmacological research IF: 10.500Ahead of Print.No.05The Addicted Brain: How Processed Foods Hijack Reward Pathways成瘾的大脑：加工食品如何劫持奖赏通路DOI: 10.1016/j.phrs.2026.108097
BMC medicine IF: 08.300Ahead of Print.No.06SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis2型糖尿病合并代偿期肝硬化患者使用SGLT-2抑制剂的肝脏相关及死亡率结局DOI: 10.1186/s12916-026-04629-x
BMC health services research IF: 03.000Ahead of Print.No.07Facilitating a complex behaviour-change intervention: healthcare professionals' accounts of their journeys to competence and confidence促进一项复杂的行为改变干预：医疗专业人员对其胜任力与信心建立之路的叙述DOI: 10.1186/s12913-025-13676-8
Aging Clin Exp Res IF: 03.400Ahead of Print.No.08Prevalence and predictive factors of cognitive impairment among hospitalized older adults in iran: a cross-sectional study, 2024伊朗住院老年患者认知障碍的患病率及预测因素：一项2024年横断面研究DOI: 10.1007/s40520-025-03299-8
Nature metabolism IF: 20.800Ahead of Print.No.09AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasisAMPK：营养感知、代谢通量与能量稳态的枢纽DOI: 10.1038/s42255-025-01442-3
Nature metabolism IF: 20.800Ahead of Print.No.10Single-cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss人类皮下脂肪组织在生活方式及减重手术诱导体重减轻过程中的单细胞分辨率转录动力学研究DOI: 10.1038/s42255-025-01433-4
Nature communications IF: 15.700Ahead of Print.No.11Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2跨物种证据揭示成人嗜睡症的发育起源与突触黏附分子beat-Ia/CADM2缺失相关DOI: 10.1038/s41467-026-68343-1
Signal Transduct Target Ther IF: 52.700Volume 11, Issue 1No.12MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysmMAPK14通过汇聚关键转录机制促进腹主动脉瘤中血管平滑肌细胞退化DOI: 10.1038/s41392-025-02540-0
Biol Pharm Bull IF: 01.700Volume 49, Issue 1No.13Long-Term Use of Proton Pump Inhibitors Affects Blood Levels of Indoxyl Sulfate in Japanese Patients with Chronic Kidney Disease长期使用质子泵抑制剂影响日本慢性肾脏病患者血液中硫酸吲哚酚水平DOI: 10.1248/bpb.b25-00465
Biol Pharm Bull IF: 01.700Volume 49, Issue 1No.14SMTP-44D Improves High Glucose-Induced Vascular Endothelial DysfunctionSMTP-44D改善高糖诱导的血管内皮功能障碍DOI: 10.1248/bpb.b25-00619
Genes & development IF: 07.700Ahead of Print.No.15Independent control of neurogenesis and dorsoventral patterning by NKX2-2NKX2-2独立控制神经发生与背腹侧模式形成DOI: 10.1101/gad.352886.125
BMJ open IF: 02.300Volume 16, Issue 1No.16Defining chronic ambulatory care sensitive conditions in Malaysia: a collaborative consensus study定义马来西亚慢性门诊诊疗敏感性疾病：一项共识性研究DOI: 10.1136/bmjopen-2025-099891
Physiological reviews IF: 28.700Ahead of Print.No.17Potassium channels in vascular smooth muscle cells血管平滑肌细胞中的钾离子通道DOI: 10.1152/physrev.00017.2025
Preventive medicine IF: 03.200Ahead of Print.No.18An equity audit on intervention effects of a cardiometabolic risk reduction program for women with a history of gestational diabetes in Victoria, Australia澳大利亚维多利亚州妊娠糖尿病史女性心脏代谢风险降低项目干预效果的公平性审计DOI: 10.1016/j.ypmed.2026.108509
Am J Clin Nutr IF: 06.900Ahead of Print.No.19Prediabetes, Diabetes and Folate Status among U.S. Women of Reproductive Age: National Health and Nutrition Examination Survey (NHANES) 2011-March 2020美国育龄女性的前期糖尿病、糖尿病与叶酸状态：全国健康与营养调查(NHANES) 2011年-2020年3月数据DOI: 10.1016/j.ajcnut.2026.101193
Clinical medicine : IF: 03.900Ahead of Print.No.20DIABETES: A MULTISYSTEM DISEASE NEEDING MULTI-DISCIPLINARY CARE糖尿病：一种需要多学科护理的多系统疾病DOI: 10.1016/j.clinme.2026.100554
EJCN IF: 03.900Ahead of Print.No.21Navigating comorbidity: addressing the dual burden of coronary artery disease and diabetes应对共病：管理冠状动脉疾病与糖尿病的双重负担DOI: 10.1093/eurjcn/zvaf238
Am J Physiol Gastrointest Liver Physiol IF: 03.300Ahead of Print.No.22Role of serine/threonine phosphatases 1 and 2A in pancreatic acinar fluid and electrolyte secretion丝氨酸/苏氨酸磷酸酶1和2A在胰腺腺泡液体和电解质分泌中的作用DOI: 10.1152/ajpgi.00304.2025
American journal of perinatology IF: 01.200Ahead of Print.No.23Pregnancy Outcomes in Patients with Type 1 Diabetes Using Continuous Glucose Monitoring使用连续血糖监测的1型糖尿病患者妊娠结局研究DOI: 10.1055/a-2781-7373
Nature reviews. Nephrology IF: 39.800Ahead of Print.No.24Next-generation therapeutics for diabetic kidney disease糖尿病肾病的下一代疗法DOI: 10.1038/s41581-025-01042-0
GeroScience IF: 05.400Ahead of Print.No.25Association between cardiovascular-kidney-metabolic syndrome and risks of 14 age-related health outcomes in primary prevention older population心血管-肾脏-代谢综合征与一级预防老年人群14种年龄相关健康结局风险的关联DOI: 10.1007/s11357-025-02058-x
Endocrine journal IF: 02.100Ahead of Print.No.26Pituitary dysfunction in trans-sellar encephalocele: a two-case report and a literature review经蝶鞍脑膨出中的垂体功能障碍：两例报告及文献综述DOI: 10.1507/endocrj.EJ25-0480
BMJ open IF: 02.300Volume 16, Issue 1No.27Challenges in shared decision-making about major lower limb amputation: the PERCEIVE qualitative study关于大截肢共同决策面临的挑战：PERCEIVE定性研究DOI: 10.1136/bmjopen-2025-104407
Nature microbiology IF: 19.400Ahead of Print.No.28Early-life colonization by aromatic-lactate-producing bifidobacteria lowers the risk of allergic sensitization早期生命芳香乳酸产生双歧杆菌定植降低过敏致敏风险DOI: 10.1038/s41564-025-02244-9
BMJ case reports IF: 00.500Volume 19, Issue 1No.29Hypertensive crisis due to secondary aldosteronism from polyarteritis nodosa因结节性多动脉炎继发性醛固酮增多症所致的高血压危象DOI: 10.1136/bcr-2025-269055
BMC pediatrics IF: 02.000Ahead of Print.No.30Association between vitamin D status and insulin resistance in Korean adolescents: differential effects of obesity using non-insulin-based indices韩国青少年维生素D状态与胰岛素抵抗的关联：使用非胰岛素指数评估肥胖的差异效应DOI: 10.1186/s12887-026-06510-5
International journal of obesity IF: 03.800Ahead of Print.No.31Metabolic remodeling and the modulatory role of vitamin D deficiency in African American children and adolescents with obesity非裔美国儿童与青少年肥胖中的代谢重塑及维生素D缺乏的调节作用DOI: 10.1038/s41366-025-02003-0
J Vet Med Sci IF: 01.100Ahead of Print.No.32Hematological, biochemical and hormonal profiles in dogs with obesity-related metabolic disorder犬肥胖相关代谢紊乱的血常规、生化及激素特征分析DOI: 10.1292/jvms.25-0381
Molecular medicine IF: 06.400Ahead of Print.No.33Hepatic loss of AATF attenuates MASH by suppressing AKT-mTORC1 signaling and reprogramming lipid metabolism肝脏缺失AATF通过抑制AKT-mTORC1信号通路与重编程脂质代谢缓解MASHDOI: 10.1186/s10020-025-01417-w
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.34Association of Insulin Therapy with Diabetic Retinopathy in Type 2 Diabetes: A Cross-Sectional Analysis from the Beichen Eye Study胰岛素治疗与2型糖尿病视网膜病变的关联：基于北辰眼研究的横断面分析DOI: 10.1016/j.pdpdt.2026.105345
BMC anesthesiology IF: 02.600Ahead of Print.No.35Anaesthetic management of a pregnant woman with Brugada syndrome undergoing Caesarean section: a case report一例患有布鲁加达综合征的孕妇行剖宫产术的麻醉管理：病例报告DOI: 10.1186/s12871-025-03600-2
BMC psychology IF: 03.000Ahead of Print.No.36Psychological flexibility patterns in patients with type 2 diabetes mellitus and its associations with self-care behavior and medical condition2型糖尿病患者的心理灵活性模式及其与自我护理行为和医疗状况的关联DOI: 10.1186/s40359-025-03930-3
BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.37Is gastroesophageal reflux linked to inflammation-related gestational complications and poor obstetric history?胃食管反流病是否与炎症相关性妊娠并发症及不良产科史有关？DOI: 10.1186/s12884-026-08640-1
Digestive diseases and sciences IF: 02.500Ahead of Print.No.38Impact of Type 2 Diabetes Mellitus on Liver Fibrosis and Hepatic Steatosis in Patients with Primary Biliary Cholangitis: A Longitudinal Study2型糖尿病对原发性胆汁性胆管炎患者肝纤维化和肝脂肪变性的影响：一项纵向研究DOI: 10.1007/s10620-026-09672-5
Clin Microbiol Infect IF: 08.500Ahead of Print.No.39Prevalence and clinical outcomes of RSV, COVID-19, and influenza among older hospitalized adults: The EVERY prospective cohort study老年住院成人中RSV、COVID-19及流感的患病率与临床结局：EVERY前瞻性队列研究DOI: 10.1016/j.cmi.2026.01.002
The Journal of arthroplasty IF: 03.800Ahead of Print.No.40Patients Who Have Metabolic Syndrome Have a Higher Chance of Postoperative Complications After Total Hip Arthroplasty代谢综合征患者在全髋关节置换术后发生并发症的风险更高DOI: 10.1016/j.arth.2026.01.038
CVIR IF: 02.900Ahead of Print.No.41Clinical Outcomes of Balloon-Only Venous Arterialization for Chronic Limb-Threatening Ischemia After Failed or Unfeasible Revascularization单纯球囊静脉动脉化治疗血运重建失败或不可行的慢性肢体威胁性缺血的临床结局DOI: 10.1007/s00270-025-04323-0
PloS one IF: 02.600Volume 21, Issue 1No.42Prevalence, demographic factors, co-morbidities, and treatment types associated with acanthosis nigricans in a large cross-section of 900+ transmasculine patients: Data from a single academic center 2016-2023900余名跨男性患者中黑棘皮病的患病率、人口学因素、合并症及治疗类型关联分析：基于单一学术中心2016-2023年数据DOI: 10.1371/journal.pone.0340907
PloS one IF: 02.600Volume 21, Issue 1No.43ACMTF-R: Supervised multi-omics data integration uncovering shared and distinct outcome-associated variationACMTF-R：基于监督的多组学数据整合，揭示与结果相关的共同及特异性变异DOI: 10.1371/journal.pone.0339650
A&A practice IF: 00.600Volume 19, Issue 12No.44Enhanced Ventilation Strategies in Bariatric Surgery: A Case Report of Flow-Controlled Ventilation in an Extremely Obese Patient Undergoing Robot-Assisted Bariatric Surgery减重手术中增强的通气策略：机器人辅助减重手术中一例极度肥胖患者的流量控制通气病例报告DOI: 10.1213/XAA.0000000000002111
Journal of animal science IF: 02.900Ahead of Print.No.45Overnutrition induced metabolic dysregulation and partially decreased semen quality in young beef bulls营养过剩诱导年轻肉牛代谢失调并部分降低精子质量DOI: 10.1093/jas/skag004
Food & function IF: 05.400Volume 17, Issue 1No.46Hypoglycemic effects under in vitro digestion of brewer's spent yeast β-glucan concentrate added to a rice extrudate酿酒酵母β-葡聚糖浓缩物添加于大米挤压膨化产品后的体外消化降血糖效应DOI: 10.1039/d5fo03588k
Diabetes care IF: 16.600Ahead of Print.No.47Impact of Maternal Diabetes in Pregnancy on Newborn IgG Antibody Repertoire and Infection Risk in the First Six Months of Life母体孕期糖尿病对新生儿IgG抗体谱及生命前六个月感染风险的影响DOI: 10.2337/dc25-0990
Hormone research in p?diatrics : IF: 02.700Volume 99, Issue 1No.48Insulin-Induced Copeptin Response in Children and Adolescents to Diagnose Arginine Vasopressin Deficiency胰岛素诱导的和肽素反应在诊断儿童和青少年精氨酸加压素缺乏症中的应用DOI: 10.1159/000541330
Yàowù shípǐn fēnxī IF: 03.000Volume 33, Issue 4No.49Selective sodium-glucose cotransporter two inhibitor empagliflozin ameliorates diabetic cardiomyopathy by activating the AMPK/TFEB signaling pathway选择性钠-葡萄糖协同转运蛋白2抑制剂恩格列净通过激活AMPK/TFEB信号通路改善糖尿病心肌病DOI: 10.38212/2224-6614.3563
Yàowù shípǐn fēnxī IF: 03.000Volume 33, Issue 4No.50Economic evaluation of AI-assisted technologies in healthcare: A systematic review医疗健康领域AI辅助技术的经济学评价：一项系统综述DOI: 10.38212/2224-6614.3570
Brazilian Journal of Nephrology IF: 01.300Volume 48, Issue 2No.51The role of probiotics in modulating the gut microbiota as a potential inhibitor of diabetic kidney disease progression益生菌通过调节肠道菌群作为潜在抑制剂延缓糖尿病肾病进展的机制DOI: 10.1590/2175-8239-JBN-2025-0143en
Annals of Internal Medicine IF: 15.200Ahead of Print.No.52Correction: Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes能量减少地中海饮食与体力活动对比自由摄取地中海饮食预防2型糖尿病的比较DOI: 10.7326/ANNALS-25-04192
Annals of Internal Medicine IF: 15.200Ahead of Print.No.53Predicting Long-Term Risk for Prostate Cancer Mortality Following a Prostate-Specific Antigen Screening Test: Prognostic Model Development and External Validation预测前列腺特异性抗原筛查后前列腺癌死亡的长期风险：预后模型的开发与外部队列验证DOI: 10.7326/ANNALS-25-02036
Natural product research IF: 01.600Ahead of Print.No.54Antitumor and in vivo antioxidant activity of 24-nor-olean-3-one-28-oic acid isolated from the roots of momordica cymbalaria (hook. F.) fenzl ex naudin in Ehrlich ascites carcinoma transplanted mice从Momordica cymbalaria根部分离的24-nor-olean-3-one-28-oic酸在艾氏腹水癌移植小鼠体内的抗肿瘤及体内抗氧化活性DOI: 10.1080/14786419.2026.2615749
ACS chemical neuroscience IF: 03.900Ahead of Print.No.55Synergistic Effect of Mutations in the Amyloidogenic Core of Human Amylin (hAM) Affords a New Potent Inhibitor of hAM Fibrillation: Computational Design and Experimental Validation人类胰淀素（hAM）淀粉样核心突变协同效应产生新型强效hAM纤维化抑制剂：计算设计与实验验证DOI: 10.1021/acschemneuro.5c00433
Neuroepidemiology IF: 04.000Ahead of Print.No.56Incidence, Prevalence, and Treatment Patterns in Chronic Inflammatory Demyelinating Polyneuropathy: Data Analysis of United States Claims慢性炎性脱髓鞘性多发性神经病的发病率、患病率及治疗模式：美国索赔数据分析DOI: 10.1159/000550418
Kidney & Blood Pressure Research IF: 02.100Ahead of Print.No.57Clinical Profile and Outcome of C3-dominant Glomerulonephritis: Retrospective studyC3优势性肾小球肾炎的临床特征与预后：一项回顾性研究DOI: 10.1159/000550422
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.58Nutrition and healthy lifestyles for children and adolescents with early-stage type 1 diabetes针对早期1型糖尿病儿童和青少年的营养与健康生活方式指导DOI: 10.1159/000550434
Eur J Endocrinol IF: 05.200Ahead of Print.No.59Quality of Life in Patients with Pheochromocytoma and Paraganglioma: Influence of Tumor Type, Genetics and Surgical Resection嗜铬细胞瘤和副神经节瘤患者的生活质量：肿瘤类型、遗传学和手术切除的影响DOI: 10.1093/ejendo/lvag003
Eur J Endocrinol IF: 05.200Ahead of Print.No.60Effects of GLP-1 Receptor Agonists on Copeptin in Euvolemic ParticipantsGLP-1受体激动剂对血容量正常参与者中肽素水平的影响DOI: 10.1093/ejendo/lvag005
J Clin Gastroenterol IF: 02.700Ahead of Print.No.61Metabolic Comorbidities and Hospital Outcomes in Patients With Inflammatory Bowel Disease: A Nationwide Analysis炎症性肠病患者的代谢合并症与住院结局：一项全国性分析DOI: 10.1097/MCG.0000000000002333
Am J Gastroenterol IF: 07.600Ahead of Print.No.62Postimaging Colorectal Cancer After Computed Tomography Colonography: A Danish Nationwide StudyCT结肠成像检查后的影像后结直肠癌：一项丹麦全国性研究DOI: 10.14309/ajg.0000000000003849
Diabetes care IF: 16.600Ahead of Print.No.63Empagliflozin in HNF1A-MODY (MODY3)-a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial恩格列净在HNF1A-MODY（MODY3）中的疗效——一项随机、双盲、安慰剂对照、交叉试验DOI: 10.2337/dc25-2572
Neurology IF: 08.500Volume 106, Issue 3No.64Development of a Prognostic Model for Poststroke Dementia Using Multiple International Cohorts: A STROKOG Collaboration Study利用多国队列开发卒中后痴呆预后模型：一项STROKOG合作研究DOI: 10.1212/WNL.0000000000214574
Diabetes IF: 07.500Ahead of Print.No.65Amino Acid Sensing by the α-Cell Mitochondrial Phosphoenolpyruvate Cycle Regulates Intracellular Ca2+ Levels Without Affecting Glucagon Secretionα细胞线粒体磷酸烯醇丙酮酸循环通过感知氨基酸调节细胞内钙离子水平而不影响胰高血糖素分泌DOI: 10.2337/db25-0510
La Clinica terapeuticaVolume 177, Issue 1No.66Intelligent Monitoring of Health Conditions in Patients with Diabetes in the Context of Healthcare Digitalization医疗数字化背景下糖尿病患者的智能健康监测DOI: 10.7417/CT.2026.1981
JAMA Internal Medicine IF: 23.300Ahead of Print.No.67High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes: A Secondary Analysis of the DANFLU-2 Randomized Clinical Trial高剂量与标准剂量流感疫苗在老年糖尿病患者中的比较：DANFLU-2随机临床试验的二次分析DOI: 10.1001/jamainternmed.2025.7286
JAMA Neurology IF: 21.300Ahead of Print.No.68Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis母亲妊娠结局与子代成人发病型多发性硬化症风险DOI: 10.1001/jamaneurol.2025.5255
Journal of behavioral medicine IF: 02.900Ahead of Print.No.69Diabetes Distress and Glycemic Stability: The Mediating Role of Experiential Avoidance and Disordered Eating in Type 1 Diabetes糖尿病相关心理压力与血糖稳定性：经验性回避与饮食失调在1型糖尿病中的中介作用DOI: 10.1007/s10865-025-00623-5
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.70Fisetin-loaded Nanoemulsion and Fecal Microbiome Extract Enhance In Vitro Inhibition of Non-Small Cell Lung Cancer Progression负载漆黄素的纳米乳剂与粪便微生物组提取物协同提升体外实验中对非小细胞肺癌进展的抑制效果DOI: 10.1007/s12013-025-01981-2
Pituitary IF: 03.400Volume 29, Issue 1No.71The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells生长激素对免疫衰老的影响：探索B细胞和T细胞的作用DOI: 10.1007/s11102-025-01632-y
Osteoporosis international IF: 05.400Ahead of Print.No.72Non-metastatic breast cancer patients discontinuing aromatase inhibitor on denosumab: what next?停用芳香化酶抑制剂并正在使用地舒单抗的非转移性乳腺癌患者：后续如何治疗？DOI: 10.1007/s00198-025-07798-2
Osteoporosis international IF: 05.400Ahead of Print.No.73Post-fracture care and predictors of anti-osteoporotic treatment in Switzerland: a nationwide health claims analysis瑞士骨折后护理及抗骨质疏松治疗预测因素：一项全国性健康索赔数据分析DOI: 10.1007/s00198-025-07832-3
J Asian Nat Prod Res IF: 01.300Ahead of Print.No.74Methyl jasmonate protects liver and pancreas tissues of adult diabetic rats from STZ-induced oxidative stress damage茉莉酸甲酯保护成年糖尿病大鼠的肝脏和胰腺组织免受STZ诱导的氧化应激损伤DOI: 10.1080/10286020.2025.2611910
Endocrine-related cancer IF: 04.600Ahead of Print.No.75Prevalence and Clinical Characteristics of Lynch Syndrome-associated Adrenocortical Carcinoma林奇综合征相关肾上腺皮质癌的患病率与临床特征DOI: 10.1530/ERC-25-0389
Aging cell IF: 07.100Volume 25, Issue 2No.76Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage雷帕霉素通过增强对DNA损伤的抵抗力，在衰老的人类免疫系统中发挥其延缓衰老的作用DOI: 10.1111/acel.70364
Clinical toxicology IF: 03.300Ahead of Print.No.77A retrospective study of centipede bites in Guadeloupe, West Indies: epidemiology, medical and surgical management法属瓜德罗普岛蜈蚣咬伤回顾性研究：流行病学特征及内外科处理DOI: 10.1080/15563650.2025.2591338
Organic & biomolecular chemistry IF: 02.700Ahead of Print.No.78C(3)-H alkenylation of quinoxalin-2(1H)-ones with Hantzsch esters and in silico studies利用Hantzsch酯对喹喔啉-2(1H)-酮进行C(3)-H烯基化反应及计算机模拟研究DOI: 10.1039/d5ob01795e
Journal of molecular histology IF: 02.200Volume 57, Issue 1No.79Combined effects of chronic high glucose and fluoride exposure on kidney cells: exploratory in vitro and in vivo study慢性高糖与氟化物暴露对肾脏细胞的联合效应：一项探索性的体外与体内研究DOI: 10.1007/s10735-025-10670-6
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.80Utility of diffusion tensor imaging for assessing bone quality in type 2 diabetes: correlation with bone turnover biomarkers扩散张量成像评估2型糖尿病骨质量的效用：与骨转换生物标志物的相关性DOI: 10.1007/s11657-025-01643-z
La Clinica terapeuticaVolume 177, Issue 1No.81Determinants of Non-Adherence to the Mediterranean Diet Among Healthcare Workers: A cross-sectional study医护人员不坚持地中海饮食的决定因素：一项横断面研究DOI: 10.7417/CT.2026.1985
European journal of nutrition IF: 04.300Volume 65, Issue 1No.82Can vegetables intake pattern mediate the relationship between fast-food and cognitive performance in adolescents? The Cogni-Action project蔬菜摄入模式在快餐与青少年认知表现关系中的中介作用：Cogni-Action项目DOI: 10.1007/s00394-025-03884-7
Journal of endocrinology IF: 03.900Ahead of Print.No.83Fat's All, Folks: Culturing and Manipulating Peri-Prostatic Adipocytes to Probe Impacts on Prostate Cancer Biology脂肪的奥秘：培养与操纵前列腺周围脂肪细胞以探究其对前列腺癌生物学的影响DOI: 10.1530/JOE-25-0256
European Journal of Immunology IF: 03.700Volume 56, Issue 1No.84The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells肥胖和衰老中观察到的乳酸分泌增加导致致病性B细胞的产生DOI: 10.1002/eji.70120
Chronobiology international IF: 01.700Ahead of Print.No.85Light matters: Investigating the influence of natural and artificial light on BMI and key mediators光线的重要性：调查自然光与人工光对BMI及其关键中介因素的影响DOI: 10.1080/07420528.2025.2606281
Cutaneous and ocular toxicology IF: 01.300Ahead of Print.No.86Alternative models for evaluation of ocular toxicological effects of environmental chemicals and pharmaceuticals: a review评估环境化学品与药物眼毒性效应的替代模型：一篇综述DOI: 10.1080/15569527.2025.2607700
Abdominal radiology IF: 02.200Ahead of Print.No.87AI for screening in healthcare: promise and challenges人工智能在医疗筛查中的应用：前景与挑战DOI: 10.1007/s00261-025-05370-4
North Carolina medical journalVolume 86, Issue 3No.88Barriers to Care in Hispanic American Patients with Diabetic Retinopathy西班牙裔美国糖尿病视网膜病变患者面临的护理障碍DOI: 10.18043/001c.143309
J Gerontol B Psychol Sci Soc Sci IF: 03.200Volume 81, Issue 2No.89Heterogeneity in Asian Americans' mortality trends, 2000-2022亚裔美国人死亡率趋势的异质性：2000-2022年DOI: 10.1093/geronb/gbaf248
Current microbiology IF: 02.600Volume 83, Issue 2No.90Green Synthesis and Bioactivity Evaluation of Silver Nanoparticles from Stevia rebaudiana and the Endophyte Aspergillus versicolor利用甜叶菊及其内生真菌泡盛曲霉绿色合成银纳米颗粒及其生物活性评估DOI: 10.1007/s00284-025-04712-1
JAMA Network Open IF: 09.700Volume 9, Issue 1No.91Volunteering and Metabolic Syndrome and Diabetes in Black Adolescents From Low-Income Families志愿服务与低收入家庭黑人青少年的代谢综合征和糖尿病DOI: 10.1001/jamanetworkopen.2025.53419
Minerva anestesiologica IF: 02.800Ahead of Print.No.92Pregabalin versus dexmedetomidine for postoperative delirium in cardiac surgery: a pragmatic step forward?普瑞巴林与右美托咪定用于心脏手术后谵妄：一项务实的进步？DOI: 10.23736/S0375-9393.25.19648-X
Expert Rev Pharmacoecon Outcomes Res IF: 01.500Ahead of Print.No.93Real-world healthcare resource utilization and medical costs in patients with overweight or obesity and multimorbidity treated with semaglutide in the United States美国超重或肥胖合并多重共病患者使用司美格鲁肽的真实世界医疗资源利用与医疗成本分析DOI: 10.1080/14737167.2025.2610206
Neurological sciences IF: 02.400Volume 47, Issue 1No.94The effect of GLP-1 receptor agonists on cognition in nondiabetic patients with mild cognitive impairment or alzheimer's disease: a meta-analysis of randomized controlled trialsGLP-1受体激动剂对非糖尿病轻度认知障碍或阿尔茨海默病患者认知功能影响的荟萃分析DOI: 10.1007/s10072-025-08602-z
Tremor Other Hyperkinet Mov (N Y) IF: 02.100Volume 16, Issue No.95Proceedings of the 12(th) International Meeting on Neuroacanthocytosis, Cohen Syndrome, and Other VPS13-Related Disorders第12届神经棘红细胞增多症、Cohen综合征及其他VPS13相关疾病国际会议纪要DOI: 10.5334/tohm.1124
Drugs - real world outcomes IF: 01.900Ahead of Print.No.96Trends in Adverse Event Reports of Dipeptidyl Peptidase-4 Inhibitor-Associated Pemphigoid in Japan日本二肽基肽酶-4抑制剂相关性天疱疮不良事件报告趋势DOI: 10.1007/s40801-025-00535-5
J Cardiovasc Med IF: 02.000Ahead of Print.No.97Hypokinetic nondilated cardiomyopathy: clinical characteristics, prognosis, and therapy response compared to dilated cardiomyopathy相比扩张型心肌病，非扩张性低动力性心肌病的临床特征、预后和治疗反应DOI: 10.2459/JCM.0000000000001813
La Clinica terapeuticaVolume 177, Issue 1No.98Metabolic and Hormonal Impact of Subclinical Hypothyroidism in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study from South India印度南部多囊卵巢综合征女性中亚临床甲状腺功能减退症的代谢与激素影响：一项横断面研究DOI: 10.7417/CT.2026.1983
Am J Physiol Cell Physiol IF: 04.700Ahead of Print.No.99Ablation of Tumor-Derived IGFBP-3 Attenuates Cancer-Associated Skeletal Muscle Wasting in Murine Pancreatic Cancer敲除肿瘤来源的IGFBP-3可减轻小鼠胰腺癌相关的骨骼肌消耗DOI: 10.1152/ajpcell.00421.2025
Diabetes IF: 07.500Ahead of Print.No.100GLP-1, Pancreatic β-Cells, and Insulin Secretion: What We Know and Where We Need to GoGLP-1、胰腺β细胞与胰岛素分泌：已知与待探索DOI: 10.2337/db25-0695
Diabetes IF: 07.500Ahead of Print.No.101Identifying Insulin Autoantibodies With Differential Risk in Type 1 Diabetes With a Novel Bridging ELISA利用新型桥接酶联免疫吸附法鉴定具有不同风险的1型糖尿病胰岛素自身抗体DOI: 10.2337/db25-0696
Pituitary IF: 03.400Volume 29, Issue 1No.102Comparison of oral versus intravenous glucose exposure on plasma growth hormone levels: a crossover study in healthy volunteers口服与静脉葡萄糖暴露对血浆生长激素水平的比较：一项健康志愿者的交叉研究DOI: 10.1007/s11102-025-01633-x
Molecular neurobiology IF: 04.300Volume 63, Issue 1No.103Valacyclovir Mitigates Amyloid Plaque Deposition, P-Tau Aggregation, and Neuroinflammation in Streptozotocin induced Alzheimer's Disease Rat Model伐昔洛韦减轻链脲佐菌素诱导的阿尔茨海默病大鼠模型中的淀粉样斑块沉积、p-Tau聚集及神经炎症DOI: 10.1007/s12035-025-05652-4
Nutrition reviews IF: 04.900Ahead of Print.No.104The Effects of Probiotic Supplementation on Bisphenol A Toxicity: A Systematic Literature Review益生菌补充对双酚A毒性的影响：一项系统文献综述DOI: 10.1093/nutrit/nuaf272
Adv Clin Exp Med IF: 01.900Ahead of Print.No.105Simple, low-cost in vitro protocol for differentiating mesenchymal stem cells into cardiomyocyte-like cells将间充质干细胞分化为心肌细胞样细胞的简单、低成本体外方案DOI: 10.17219/acem/204112
J Am Nutr Assoc IF: 02.600Ahead of Print.No.106Effects of Brassica juncea Seed Extract on Diabetes-Related Gene Expression Profiling of Pancreatic β-Cells in a Rat Model: Relevance to Environmental and Health Safety芥菜籽提取物对大鼠模型胰腺β细胞糖尿病相关基因表达谱的影响：与环境和健康安全的相关性DOI: 10.1080/27697061.2025.2596999
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 125, Issue 12No.107[Relationship of glycemic, metabolic, immuno-inflammatory, and psychopathological parameters in patients with depressive disorder: a retrospective analysis]抑郁障碍患者血糖、代谢、免疫炎症及精神病理参数的相关性：一项回顾性分析DOI: 10.17116/jnevro2025125121223
Biologie aujourd'huiVolume 219, Issue 3-4No.108[Popular myths vs. physiological realities: The rehabilitation of lactate]流行误解 vs. 生理现实：乳酸的平反DOI: 10.1051/jbio/2025010
Am J Med Qual IF: 01.300Ahead of Print.No.109Determining Causes of Insulin-Induced Hypoglycemia Using an Electronic-Based Trigger使用电子触发器确定胰岛素诱导低血糖的原因DOI: 10.1097/JMQ.0000000000000280
World J Exp MedVolume 15, Issue 3No.110Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer差异血浆蛋白水平在上皮性卵巢癌诊断中的临床意义DOI: 10.5493/wjem.v15.i3.107711
FASEB bioAdvances IF: 02.000Volume 8, Issue 1No.111The Gut Microbiota-Insulin Resistance Axis: Mechanisms, Clinical Implications, and Therapeutic Potential肠道菌群-胰岛素抵抗轴：机制、临床意义与治疗潜力DOI: 10.1096/fba.2025-00218
Translational sports medicineVolume 2026, Issue No.112Associations Between Handgrip Strength and Markers of Insulin Resistance and Inflammation in Childhood and Adolescence: A Systematic Review With Meta-Analysis儿童青少年握力与胰岛素抵抗及炎症标志物关联性：系统综述与荟萃分析DOI: 10.1155/tsm2/1091342
Diabetes spectrumVolume 38, Issue 5No.113Racial Disparities in the Use of Automated Insulin Delivery Systems in Youth With Type 1 Diabetes青少年1型糖尿病患者中自动胰岛素输送系统使用的种族差异DOI: 10.2337/ds25-0023
Diabetes spectrumVolume 38, Issue 5No.114Observations of Glucagon-Prescribing Patterns for High-Risk People With Diabetes Within a Federally Qualified Health Center在一家联邦合格医疗中心内对高风险糖尿病患者胰高血糖素处方模式的观察DOI: 10.2337/ds25-0044
Diabetes spectrumVolume 38, Issue 5No.115Factors Considered Important by Diabetes Providers Before Recommending Automated Insulin Delivery Systems: Observations From the T1D Exchange Quality Improvement Collaborative糖尿病提供者在推荐自动胰岛素输送系统前考虑的重要因素：来自T1D Exchange质量改进协作组的观察DOI: 10.2337/ds25-0009
Case reports in nephrologyVolume 2026, Issue No.116A Case of Post-Transplantation Lymphoproliferative Disorder Following Kidney Transplantation肾移植后移植后淋巴组织增生性疾病一例DOI: 10.1155/crin/5917161
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.117The spectrum of exogenous insulin requirement in people living with type 1 diabetes: A cross-sectional analysis1型糖尿病患者外源性胰岛素需求谱：一项横断面分析DOI: 10.1111/dom.70467
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.118Long-acting insulin analogues and the risk of diabetic nephropathy among patients with type 2 diabetes: A population-based cohort study长效胰岛素类似物与2型糖尿病患者糖尿病肾病风险：一项基于人群的队列研究DOI: 10.1111/dom.70397
Development IF: 03.600Ahead of Print.No.119Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line前滞育期饥饿快速且可逆地降低秀丽隐杆线虫生殖系的微环境增殖信号DOI: 10.1242/dev.204972
JCRPE IF: 01.500Ahead of Print.No.120The Relationship Between HbA1c and GMI and Glucose Metrics in Children and Adolescents with Type 1 Diabetes Using AID儿童与青少年1型糖尿病患者使用自动化胰岛素输注系统时HbA1c、GMI与血糖指标间的关系DOI: 10.4274/jcrpe.galenos.2025.2025-10-11
Journal of materials chemistry IF: 05.700Ahead of Print.No.121Surfactin-inspired arginine- and lysine-rich peptides inhibit human insulin aggregation and prevent amyloid-induced cytotoxicity受表面活性素启发的富含精氨酸与赖氨酸多肽抑制人胰岛素聚集并防止淀粉样蛋白诱导的细胞毒性DOI: 10.1039/d5tb01952d
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.122Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways血清尿酸：胰岛素抵抗的潜在介导者及其分子机制与代谢通路DOI: 10.1002/edm2.70163
Nursing standardAhead of Print.No.123Recognising, managing and reducing the risk of hypoglycaemia in adults with diabetes成人糖尿病患者低血糖风险的识别、管理与降低DOI: 10.7748/ns.2026.e12574
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.124Insulin Receptor Family Autoantibodies in Patients with Type B insulin ResistanceB型胰岛素抵抗患者的胰岛素受体家族自身抗体DOI: 10.1210/clinem/dgaf692
Ther Adv Psychopharmacol IF: 04.000Volume 16, Issue No.125A description of antipsychotic prescribing patterns on the inpatient behavioral health setting: a multicenter cross-sectional analysis住院行为健康环境中抗精神病药物处方模式的描述：一项多中心横断面分析DOI: 10.1177/20451253251394296
World J Exp MedVolume 15, Issue 3No.126Effect of propolis and honey in hyperglycemia-induced kidney and liver injuries, proteinuria, and oxidant and antioxidant parameters蜂胶与蜂蜜对高血糖所致肾肝损伤、蛋白尿及氧化与抗氧化参数的影响DOI: 10.5493/wjem.v15.i3.99330
World J Exp MedVolume 15, Issue 3No.127Relationship of diabetes mellitus with prognostic factors in breast cancer糖尿病与乳腺癌预后因素的关系DOI: 10.5493/wjem.v15.i3.108318
Int J Endocrinol IF: 02.300Volume 2026, Issue No.128Correction to "Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate"《虾青素通过调控微小RNA、溶血磷脂酰胆碱和α-羟基丁酸调节2型糖尿病炎症》一文更正DOI: 10.1155/ije/9845896
Ther Adv Endocrinol Metab IF: 04.600Volume 17, Issue No.129Accuracy and feasibility of real-time continuous glucose monitoring in early postoperative intensive care after liver transplantation肝移植术后早期重症监护中实时连续血糖监测的准确性与可行性DOI: 10.1177/20420188251405372
Curēus IF: 01.300Volume 17, Issue 12No.130Shewanella algae as a Rare Cause of Bullous Cellulitis and Sepsis: The First Reported Case in Lithuania希瓦氏藻作为大疱性蜂窝织炎和脓毒症的罕见病因：立陶宛首例报告病例DOI: 10.7759/cureus.98958
Curēus IF: 01.300Volume 17, Issue 12No.131A Rare Case of Parathyroid Carcinoma Initially Misdiagnosed as a Parathyroid Adenoma一例最初被误诊为甲状旁腺腺瘤的罕见甲状旁腺癌病例DOI: 10.7759/cureus.98794
Curēus IF: 01.300Volume 17, Issue 12No.132Impact of Long-Term Glucocorticoid Therapy on the Response to Biologic Agents in Rheumatoid Arthritis: A Prospective Observational Study长期糖皮质激素治疗对类风湿关节炎生物制剂疗效的影响：一项前瞻性观察研究DOI: 10.7759/cureus.98824
Curēus IF: 01.300Volume 17, Issue 12No.133Functional Magnetic Resonance Imaging (fMRI) and Music Therapy for Concussion: A Case Report功能性磁共振成像与音乐疗法治疗脑震荡：一例病例报告DOI: 10.7759/cureus.98823
Curēus IF: 01.300Volume 17, Issue 12No.134Neutrophil-to-Lymphocyte Ratio Correlation With the Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome中性粒细胞与淋巴细胞比值与非ST段抬高型急性冠状动脉综合征患者SYNTAX评分的相关性DOI: 10.7759/cureus.98890
Curēus IF: 01.300Volume 17, Issue 12No.135Outcomes of Free Flap Surgery in Head and Neck Cancer Patients With Chronic Kidney Disease: A Single-Institution Retrospective Study of 61 Cases慢性肾脏病头颈癌患者游离皮瓣手术结局：61例单中心回顾性研究DOI: 10.7759/cureus.98897
Curēus IF: 01.300Volume 17, Issue 12No.136Atypical Presentation of Chronic Left Anterior Descending Occlusion: Heart Failure Without Angina as the Initial Manifestation慢性左前降支闭塞的不典型表现：心力衰竭作为首发症状而无心绞痛DOI: 10.7759/cureus.98903
Curēus IF: 01.300Volume 17, Issue 12No.137Late-Onset NR0B1-Related Adrenal Hypoplasia Congenita Presenting With Primary Adrenal Insufficiency and Pubertal Delay表现为原发性肾上腺皮质功能减退症和青春期延迟的迟发性NR0B1相关性先天性肾上腺发育不全DOI: 10.7759/cureus.98859
Indian J Radiol ImagingVolume 36, Issue 1No.138Spectrum of Typical and Atypical Imaging Findings and Pathological Features in Diabetic Mastopathy糖尿病性乳腺病的典型与非典型影像学表现及病理特征的谱系分析DOI: 10.1055/s-0045-1808258
J Curr Glaucoma PractVolume 19, Issue 4No.139The Influence of Hemodialysis on Ocular Pressure Dynamics: An Observational Study on IOP and OPP Changes血液透析对眼压动态的影响：一项关于IOP和OPP变化的观察性研究DOI: 10.5005/jp-journals-10078-1497
J Curr Glaucoma PractVolume 19, Issue 4No.140Glaucoma Risk Reduction as a Secondary Benefit of Glucagon-like Peptide-1 Receptor Agonists: A Review of Emerging Evidence胰高血糖素样肽-1受体激动剂降低青光眼风险作为次要获益：新兴证据综述DOI: 10.5005/jp-journals-10078-1501
Am J Lifestyle Med IF: 01.300Ahead of Print.No.141Lifestyle Interventions for Major Depressive Disorder (MDD): An Expert Consensus Statement From the American College of Lifestyle Medicine生活方式干预治疗重性抑郁障碍（MDD）：来自美国生活方式医学会的专家共识声明DOI: 10.1177/15598276251408353
F1000ResearchVolume 13, Issue No.142Molecular Characterization of Dermatophyte species from rural tertiary care hospital: A Study Protocol农村三级医院皮肤癣菌的分子特征研究：一项研究方案DOI: 10.12688/f1000research.141657.4
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.143A Study to Asses Effects of Diabetes Mellitus on Treatment Outcome of Tuberculosis Patients一项评估糖尿病对结核病患者治疗结局影响的研究DOI: 10.4103/jpbs.jpbs_1425_25
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.144Correlation of Candida Species and Carriage in Uncontrolled and Controlled Diabetics on Various Oral Hypoglycemic Drug Regimen不同口服降糖药方案下控制与非控制糖尿病患者口腔念珠菌定植及其菌种相关性研究DOI: 10.4103/jpbs.jpbs_1372_25
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.145Awareness, Perception, and Knowledge about Oral Microbiota among College of Dentistry Students in Gulf Medical University/United Arab Emirates阿拉伯联合酋长国海湾医科大学牙科学院学生对口腔微生物群的认知、理解及知识现状DOI: 10.4103/jpbs.jpbs_1161_25
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.146Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research口服降糖药治疗的2型糖尿病患者与非糖尿病患者拔牙创愈合情况比较DOI: 10.4103/jpbs.jpbs_1240_25
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.147Periodontal Status of Medically Compromised Patients Visiting Teaching Hospitals in Riyadh City: A Retrospective Study利雅得市教学医院就诊的全身性疾病患者的牙周状况：一项回顾性研究DOI: 10.4103/jpbs.jpbs_1269_25
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.148Association Between Serum Vitamin D Levels and Glycemic Status in Prediabetic Adults糖尿病前期成人血清维生素D水平与血糖状态之间的关联DOI: 10.4103/jpbs.jpbs_1112_25
Ther Adv Drug Saf IF: 03.400Volume 17, Issue No.149Safety and risk management in clinical trials for chronic wounds with tissue regenerative products使用组织再生产品的慢性伤口临床试验中的安全性与风险管理DOI: 10.1177/20420986251385861
JBMR plus IF: 02.400Volume 10, Issue 2No.150Denosumab as a treatment for pediatric hypercalcemia-a multicenter experienceDenosumab作为儿童高钙血症的治疗：一项多中心经验DOI: 10.1093/jbmrpl/ziaf171
J Educ Teach Emerg MedVolume 10, Issue 5No.151Managing Conflict Case: Admission of a Patient with Decompensated Schizophrenia, Hypertension, and Diabetes冲突管理案例：一例失代偿性精神分裂症、高血压和糖尿病患者入院争议的化解DOI: 10.21980/J8.52341
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue 4No.152Spectrum of Deep Neck Space Abscesses: A Case Series Experience in a Tertiary Health Care Centre深颈部间隙脓肿类型谱：一家三级医疗中心的病例系列经验DOI: 10.4103/jpbs.jpbs_1490_25
Int J Biol Sci IF: 10.000Volume 22, Issue 2No.153Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population罕见JAK/STAT种系突变对蒂罗尔人群疫苗接种诱导先天免疫应答的影响DOI: 10.7150/ijbs.124098
Plastic surgery IF: 00.600Ahead of Print.No.154Treatment of Critical Hand Ischemia Due to Mycotic Aneurysm of Radial and Ulnar Arteries: A Case Report桡动脉与尺动脉真菌性动脉瘤所致危重手部缺血的治疗：病例报告DOI: 10.1177/22925503251411863
Journal of diabetes research IF: 03.400Volume 2026, Issue No.155Association Between Sodium-Glucose Cotransporter-2 Inhibitors and Sepsis Risk in Patients With Type 2 Diabetes Mellitus钠-葡萄糖协同转运蛋白2抑制剂与2型糖尿病患者脓毒症风险的相关性研究DOI: 10.1155/jdr/1437417
Curēus IF: 01.300Volume 17, Issue 12No.156Lifestyle Behavioral Self-Care Practices and Their Determinants Among Type 2 Diabetes Patients Attending a Non-communicable Disease Clinic in Agra District: A Cross-Sectional Study印度阿格拉地区非传染性疾病诊所2型糖尿病患者的生活方式行为自我护理实践及其决定因素：一项横断面研究DOI: 10.7759/cureus.98857
Avicenna J Med BiotechnolVolume 17, Issue 3No.157Ameliorating Potential of Quercetin and Curcumin on Glucose-6-Phosphate Dehydrogenase Expression via miRNAs in Rats with Type 2 Diabetes Mellitus槲皮素与姜黄素通过miRNAs改善2型糖尿病大鼠葡萄糖-6-磷酸脱氢酶表达的潜力DOI: 10.18502/ajmb.v17i3.19280
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.158Evaluation of Hematological Changes in Type 2 Diabetes Mellitus and Their Correlation with Glycemic Control评估2型糖尿病患者的血液学变化及其与血糖控制的相关性DOI: 10.4103/jpbs.jpbs_1111_25
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.159A Cross-sectional Study of Awareness about Diabetes Mellitus and its Complications among Indian Patients with Type 2 Diabetes Mellitus印度2型糖尿病患者对糖尿病及其并发症认知度的横断面研究DOI: 10.4103/jpbs.jpbs_1417_25
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.160Genetic susceptibility to type 2 diabetes: Insights from a comprehensive meta-analysis of FABP2 polymorphisms2型糖尿病的遗传易感性：基于FABP2基因多态性的全面荟萃分析启示DOI: 10.1007/s40200-025-01847-7
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.161GLP-1 receptor agonists in kidney transplant recipients with type 2 diabetes mellitus: a systematic review and meta-analysis on mortality and major adverse kidney eventsGLP-1受体激动剂在合并2型糖尿病的肾移植受者中的应用：一项关于死亡率和主要不良肾脏事件的系统综述与荟萃分析DOI: 10.1007/s40200-025-01801-7
Aging cell IF: 07.100Volume 25, Issue 2No.162Frequently Reported Blood Biomarkers in Sarcopenia Clinical Trials: A Systematic Review and Meta-Analysis肌肉减少症临床试验中常报告的血源性生物标志物：一项系统综述与荟萃分析DOI: 10.1111/acel.70361
Curēus IF: 01.300Volume 18, Issue 1No.163Sight Unseen: Glucagon-Like Peptide-1 (GLP-1) Agonism Therapy and Nonarteritic Anterior Ischemic Optic Neuropathy视而不见：胰高血糖素样肽-1（GLP-1）激动剂治疗与非动脉炎性前部缺血性视神经病变DOI: 10.7759/cureus.100953
NPJ biomedical innovationsVolume 3, Issue 1No.164Decoding wound healing: cellular insights and technological advances解码伤口愈合：细胞见解与技术进展DOI: 10.1038/s44385-025-00046-6
Curēus IF: 01.300Volume 17, Issue 12No.165Panhypopituitarism Secondary to a Central Nervous System Germinoma继发于中枢神经系统生殖细胞瘤的全垂体功能减退症DOI: 10.7759/cureus.98887
Scientifica IF: 03.100Volume 2025, Issue No.166Characterization of Unsaponifiable Matter in Unripe Pistacia atlantica Fruits: Evaluation of Antioxidant Activity and α-Amylase Inhibitory Effect未成熟大西洋黄连木果实中不皂化物的表征：抗氧化活性与α-淀粉酶抑制效应评估DOI: 10.1155/sci5/8016775
NAR molecular medicineVolume 3, Issue 1No.167Combination of vemurafenib, pleconaril, and AG7404 attenuates enterovirus replication in vitro and in vivo维莫非尼、普莱康纳利与AG7404三联疗法在体外和体内抑制肠道病毒复制DOI: 10.1093/narmme/ugaf046
J Gastrointest Oncol IF: 02.000Volume 16, Issue 6No.168Hypercalcemia in metastatic pancreatic neuroendocrine tumor: a case report of ectopic 1,25 hydroxyvitamin D production by tumor cells and tumor-associated macrophages转移性胰腺神经内分泌肿瘤致高钙血症一例：肿瘤细胞与肿瘤相关巨噬细胞的1,25二羟基维生素D异位生成DOI: 10.21037/jgo-2025-616
Curēus IF: 01.300Volume 18, Issue 1No.169Comparative Effectiveness of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors Versus Glucagon-Like Peptide-1 (GLP-1) Agonists on Cardiovascular and Renal Outcomes in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis钠-葡萄糖协同转运蛋白2抑制剂与胰高血糖素样肽-1受体激动剂对2型糖尿病患者心血管及肾脏结局的疗效比较：一项系统综述与网络荟萃分析DOI: 10.7759/cureus.100927
Dermatol Res Pract IF: 01.900Volume 2026, Issue No.170Prurigo Pigmentosa Following Bariatric Surgery: A Comprehensive Clinicopathological Review减重手术后发生的色素性痒疹：一项综合临床病理学回顾DOI: 10.1155/drp/1993385
Diabetes spectrumVolume 38, Issue 5No.171Population Screening for Type 1 Diabetes in Pediatrics via Well-Child Visits: Barriers and Facilitators to Implementation通过儿童健康体检进行儿科1型糖尿病普遍筛查：实施障碍与促进因素DOI: 10.2337/ds25-0036
Diabetes spectrumVolume 38, Issue 5No.172Psychological Impact of Type 1 Diabetes: A Focus on Disordered Eating Behavior in Female Adolescents1型糖尿病的心理影响：聚焦女性青少年的饮食失调行为DOI: 10.2337/ds25-0001
Pediatric allergy and immunology IF: 04.500Volume 37, Issue 1No.173Food protein-induced enterocolitis syndrome in children: A swiss prospective multicenter study儿童食物蛋白诱导性肠炎综合征：一项瑞士前瞻性多中心研究DOI: 10.1111/pai.70279
Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.174Intraocular inflammation after intravitreal injection of faricimab-a case series including one case of bilateral choroidal involvement玻璃体内注射法瑞西单抗后的眼内炎症——包含一例双侧脉络膜受累的病例系列DOI: 10.18240/ijo.2026.01.23
Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.175Management of coexisting cataract and diabetic macular edema: a comparative study of dexamethasone implant versus anti-VEGF agents injections合并白内障与糖尿病性黄斑水肿的治疗：地塞米松植入剂对比抗VEGF药物注射的比较研究DOI: 10.18240/ijo.2026.01.07
Malaysian family physicianVolume 20, Issue No.176A scoping review of digital health applications for managing noncommunicable diseases in primary care post-pandemic: Lessons from the Western Pacific Region大流行后初级保健中非传染性疾病管理的数字健康应用范围综述：来自西太平洋地区的经验DOI: 10.51866/rv.919
Circulation reports IF: 01.100Volume 8, Issue 1No.177Pulse Rate Variability and All-Cause Mortality Risk in the General Japanese Population脉率变异性与日本一般人群全因死亡风险DOI: 10.1253/circrep.CR-25-0193
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 1No.178Perineal Verrucous Carcinoma Associated With Hypercalcemia: First Clinical Report of Parathyroid Hormone-Related Protein-producing Tumor与高钙血症相关的会阴部疣状癌：甲状旁腺激素相关蛋白产生性肿瘤的临床报告DOI: 10.1097/GOX.0000000000007395
Health science reports IF: 02.100Volume 9, Issue 1No.179The Role of Health-Related Factors in the Prevalence and Severity of COVID-19: A Retrospective Cohort Study Based on Sabzevar Persian Cohort Data健康相关因素在COVID-19患病率和严重程度中的作用：基于Sabzevar波斯队列数据的回顾性队列研究DOI: 10.1002/hsr2.71709
Expert opinion on drug delivery IF: 05.400Ahead of Print.No.180Application of iron oxide nanoparticles in liver drug delivery: insights into biodegradation and toxicity at cellular, tissue, and organ levels铁氧化物纳米颗粒在肝脏药物递送中的应用：从细胞、组织到器官层面的生物降解与毒性见解DOI: 10.1080/17425247.2026.2613932
RC IF: 01.300Volume 26, Issue 12No.181The Beneficial Effects of Glucagon-Like Peptide-1 Agonists on Blood Pressure: A Comprehensive Review胰高血糖素样肽-1受体激动剂对血压的有益影响：全面综述DOI: 10.31083/RCM45204
Korean J Community NutrVolume 28, Issue 6No.182[Process evaluation of a mobile healthcare program among employees with overweight and obesity: a 12-week intervention study investigating the role of engagement]超重和肥胖员工移动健康计划的过程评估：一项探讨参与度作用的12周干预研究DOI: 10.5720/kjcn.2023.28.6.466
Obesity science & practice IF: 01.900Volume 12, Issue 1No.183A Cross-Sectional Study Investigating the Relationship Between the FTO Gene Polymorphism in Relation to Obesity Traits and Vitamin D Status in AdolescenceFTO基因多态性与青少年肥胖特征及维生素D状态关系的横断面研究DOI: 10.1002/osp4.70112
Korean J Community NutrVolume 28, Issue 2No.184Changes in dietary habits and chronic diseases before and after COVID-19 by regions using data from the 2018-2020 Korea Community Health Survey and Consumer Behavior Survey for Foods: a cross-sectional study基于韩国社区健康调查与食品消费行为调查数据：COVID-19前后不同地区饮食习惯与慢性疾病的变化DOI: 10.5720/kjcn.2023.28.2.124
Korean J Community NutrVolume 28, Issue 2No.185Effectiveness of a mobile health intervention on weight loss and dietary behavior changes among employees with overweight and obesity: a 12-week intervention study investigating the role of engagement移动健康干预对超重肥胖员工体重减轻及饮食行为改变的效果：一项为期12周的干预研究探究参与度作用DOI: 10.5720/kjcn.2023.28.2.141
World J Exp MedVolume 15, Issue 3No.186Glucagon-like peptide and its receptor agonists for the treatment of rheumatic diseases胰高血糖素样肽-1及其受体激动剂用于治疗风湿性疾病DOI: 10.5493/wjem.v15.i3.107020
World J Exp MedVolume 15, Issue 3No.187Potential role of nanopharmacology in reducing neuroinflammation associated with hypertension and metabolic disorders纳米药理学在减轻高血压与代谢紊乱相关神经炎症中的潜在作用DOI: 10.5493/wjem.v15.i3.106743
Int J Nephrol IF: 01.400Volume 2026, Issue No.188Chronic Kidney Disease and Superimposed Acute Kidney Injury: Greater Impact of Acute Insults on Outcomes慢性肾脏病与并发急性肾损伤：急性打击对结局影响更甚DOI: 10.1155/ijne/1353892
Food Science and Biotechnology IF: 03.100Volume 35, Issue 1No.189Anti-obesity effect of Bifidobacterium adolescentis SPM2022, isolated from Korean adult来自韩国成人的青春双歧杆菌SPM2022的抗肥胖效应DOI: 10.1007/s10068-025-02013-8
JB & JS open access IF: 03.800Volume 11, Issue 1No.190Weight and Infantile Blount Disease: Insights from a Rural Ghanaian Cohort体重与婴儿布朗特病：来自加纳农村队列的启示DOI: 10.2106/JBJS.OA.25.00310
Curēus IF: 01.300Volume 17, Issue 12No.191Measuring Adipocytokines in Young Patients With Type 2 Diabetes Presenting to a Tertiary Care Centre in Upper Assam, India测量印度上阿萨姆地区三级医疗中心就诊的年轻2型糖尿病患者的脂肪细胞因子DOI: 10.7759/cureus.98779
Curēus IF: 01.300Volume 17, Issue 12No.192Severe Small-Bowel Obstruction in a High-Risk Patient on Long-Term Tirzepatide Therapy: A Case Report长期替尔泊肽治疗的高风险患者发生严重小肠梗阻：病例报告DOI: 10.7759/cureus.98935
Curēus IF: 01.300Volume 17, Issue 12No.193Revisiting Jenkins' Rule: Evidence-Based Insights on the Suture-to-Wound Length Ratio and Wound Dehiscence重温Jenkins规则：关于缝线长度与伤口长度比例及伤口裂开的循证见解DOI: 10.7759/cureus.98942
Curēus IF: 01.300Volume 17, Issue 12No.194Ulcer Perforation on Excluded Stomach Following Gastric Bypass Surgery: A Case Report of Atypical Presentation Without Pneumoperitoneum胃旁路术后胃囊袋溃疡穿孔：一例无气腹不典型表现病例报告DOI: 10.7759/cureus.98785
Curēus IF: 01.300Volume 17, Issue 12No.195Pregnancy After Bariatric Surgery: Hepatobiliary Implications, Maternal Outcomes, and Clinical Considerations减重手术后妊娠：肝胆影响、母体结局与临床考量DOI: 10.7759/cureus.98939
Curēus IF: 01.300Volume 17, Issue 12No.196Common Risk Factors Associated With Chronic Kidney Disease in Sudan: A Pilot Study苏丹慢性肾脏病常见相关危险因素：一项初步研究DOI: 10.7759/cureus.98780
Curēus IF: 01.300Volume 17, Issue 12No.197Early-Onset Type 2 Diabetes: A Comprehensive Review From Adolescence to Adulthood早发性2型糖尿病：从青少年到成年的全面综述DOI: 10.7759/cureus.98896
Curēus IF: 01.300Volume 17, Issue 12No.198Non-dysraphic Thoracic Spinal Lipoma in an Obese Adult Woman: A Case Report一例肥胖成年女性的非脊柱闭合不全性胸椎脂肪瘤病例报告DOI: 10.7759/cureus.98832
Avicenna J Med BiotechnolVolume 17, Issue 3No.199The Quality and Quantity of Nanoparticles Extracted from Human Adipose Tissue Derived-Mesenchymal Stem Cells从人脂肪组织来源间充质干细胞提取的纳米颗粒质量与数量研究DOI: 10.18502/ajmb.v17i3.19277
Food science & nutrition IF: 03.800Volume 14, Issue 1No.200Fermented Rice Bran: A Promising Therapeutic Agent Against High-Fat Diet-Induced Metabolic Disorders发酵米糠：一种对抗高脂饮食诱导代谢紊乱的有前景的治疗剂DOI: 10.1002/fsn3.71439
Food science & nutrition IF: 03.800Volume 14, Issue 1No.201Effects of Non-Soy Legumes on Body Weight and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials非大豆类豆科植物对体重及身体成分的影响：一项随机对照试验的系统综述与荟萃分析DOI: 10.1002/fsn3.71365
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.202Prevalence of Nonalcoholic Fatty Liver Disease in Obese Patients and its Association with Insulin Resistance Markers肥胖患者中非酒精性脂肪肝病的患病率及其与胰岛素抵抗标志物的关联DOI: 10.4103/jpbs.jpbs_1456_25
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.203Assessing Knowledge, Attitude, Practices (KAP), Lifestyle Diseases, and Psychological Well-Being among Commercial Vehicle Drivers in Central India印度中部商用车司机的知识、态度、行为、生活方式疾病及心理福祉评估DOI: 10.4103/jpbs.jpbs_1275_25
Frontiers in nutrition IF: 05.100Volume 12, Issue No.204South Asia-specific adaptation of Mediterranean diet principles: a mixed-methods review for practical and sustainable dietary habits南亚特定地中海饮食原则适配：一项关于实用与可持续饮食习惯的混合方法综述DOI: 10.3389/fnut.2025.1719686
Korean J Community NutrVolume 28, Issue 1No.205Nutritional status and dietary behavior of North Korean adolescent refugees based on Nutrition Quotient for Korean adolescents: a preliminary study基于韩国青少年营养商数的朝鲜青少年难民营养状况与饮食行为初步研究DOI: 10.5720/kjcn.2023.28.1.1
DEN open IF: 01.500Volume 6, Issue 1No.206Efficacy and Safety of a Revised Gastric Peroral Endoscopic Myo-Neurotomy Procedure for Bariatric Endoscopy in a Porcine Model改良胃经口内镜下肌神经切断术用于减重内镜治疗在猪模型中的有效性与安全性研究DOI: 10.1002/deo2.70230
BioMed research international IF: 02.300Volume 2026, Issue No.207Hypertension and Its Determinants Among White-Collar Workers: A Cross-Sectional Study Focusing on Lifestyle Risk Factors and Health Literacy白领工作者的高血压及其相关因素：一项聚焦生活方式风险因素与健康素养的横断面研究DOI: 10.1155/bmri/3545756
Npj biological timing and sleepVolume 3, Issue 1No.208Dual roles of circadian clock proteins in development and adult homeostasis昼夜节律蛋白在发育与成年稳态中的双重作用DOI: 10.1038/s44323-025-00061-1
Case reports in surgery IF: 00.500Volume 2026, Issue No.209Preoperative Glucagon-Like Peptide-1 Receptor Agonist Treatment to Allow Safe Laparoscopic Left Pancreatectomy in Extreme Obesity: The First Report术前胰高血糖素样肽-1受体激动剂治疗以允许在极端肥胖患者中安全实施腹腔镜左半胰腺切除术：病例报告DOI: 10.1155/cris/9201182
RSC medicinal chemistry IF: 03.600Ahead of Print.No.210Mitochondria-targeting symmetric diiminoguanidines: potent and selective anticancer agents against pancreatic tumors靶向线粒体的对称二亚氨基胍：强效且选择性的抗胰腺肿瘤药物DOI: 10.1039/d5md00808e
Case reports in endocrinology IF: 00.900Volume 2026, Issue No.211Adrenal Crisis Induced by Zoledronic Acid in Two Patients With Hypopituitarism: A Case Report and Literature Review唑来膦酸诱发两名垂体功能减退患者肾上腺危象：病例报告与文献回顾DOI: 10.1155/crie/8854575
Pak J Med Sci IF: 01.700Volume 41, Issue 13PINS-NNO SupplNo.212Determinants of poor prognosis after surgery for glioblastoma: A retrospective analysis of predictors of morbidity and mortality in a low-middle income country胶质母细胞瘤术后预后不良的决定因素：基于低收入国家一项回顾性分析的发病率和死亡率预测指标DOI: 10.12669/pjms.41.13(PINS-NNOS).13364
F1000ResearchVolume 14, Issue No.213Global, regional and national estimates of coexisting forms of malnutrition among the neonates, infants and young children - A secondary data analysis of Demographic & Health Surveys (DHS) from 2006 to 2024新生儿、婴幼儿及低龄儿童中共患型营养不良的全球、区域及国家评估——基于2006年至2024年人口与健康调查（DHS）的二次数据分析DOI: 10.12688/f1000research.172154.1
Korean J Community NutrVolume 28, Issue 3No.214Mercury exposure is associated with obesity: a systematic review and meta-analysis汞暴露与肥胖相关：一项系统综述和Meta分析DOI: 10.5720/kjcn.2023.28.3.192
Nutrition and metabolic insights IF: 02.200Volume 19, Issue No.215Circulating Branched-Chain Amino Acids are Associated with Higher Odds of Obesity: Findings from the FiLWHEL Study循环支链氨基酸与较高的肥胖风险相关：FiLWHEL研究的结果DOI: 10.1177/11786388251395146
Nutrition and metabolic insights IF: 02.200Volume 19, Issue No.216Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates靶向CD44-透明质酸信号通路治疗肥胖：基于小分子与纳米生物偶联物的见解DOI: 10.1177/11786388251408961
Hepatology communications IF: 04.600Volume 10, Issue 2No.217Name MASLD/MASH - and act on it命名MASLD/MASH并采取行动DOI: 10.1097/HC9.0000000000000897
Cancer medicine IF: 03.100Volume 15, Issue 1No.218Risk of Type II Diabetes Mellitus Among B-Cell Non-Hodgkin's Lymphoma SurvivorsB细胞非霍奇金淋巴瘤幸存者罹患2型糖尿病的风险DOI: 10.1002/cam4.71367
Endocrinology IF: 03.300Ahead of Print.No.219Targeting mineralocorticoid receptors to treat metabolic diseases via the adipocyte靶向盐皮质激素受体通过脂肪细胞治疗代谢性疾病DOI: 10.1210/endocr/bqag004
International wound journal IF: 02.500Volume 23internationalwoundjournal, Issue 1, Page e70808-e70813No.220A Novel Murine Model for Studying Impaired Wound Healing in Diabetes用于研究糖尿病受损伤口愈合的新型小鼠模型DOI: 10.1111/iwj.70826
Journal of cosmetic dermatology IF: 02.500Volume 25, Issue 1No.221Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning减肥药公众关注度上升及其美容后遗症认知增强：一项基于谷歌趋势的信息流行病学分析与临床诊断模式研究DOI: 10.1111/jocd.70670
MITAT : IF: 02.000Ahead of Print.No.222vNOTES versus laparoscopic chromopertubation for tubal factor and unexplained infertility: a comparative studyvNOTES与腹腔镜通染术治疗输卵管因素和不明原因不孕症的比较研究DOI: 10.1080/13645706.2026.2613118
The journal of sexual medicine IF: 03.300Volume 23, Issue 2No.223Health disparities among LGBTQ+ adults aged 33-35 in northern Finland: findings from the NFBC1986 cohort芬兰北部33-35岁LGBTQ+成人的健康差异：来自NFBC1986队列的研究发现DOI: 10.1093/jsxmed/qdaf366
Prim Health Care Res Dev IF: 01.700Volume 27, Issue No.224Developing a Weight Management and Metabolic Health Program to support patient-centred, effective, and efficient treatment for veterans with overweight or obesity: protocol for a quality improvement programme开发体重管理与代谢健康项目以支持超重或肥胖退伍军人的以患者为中心、有效且高效的治疗：一项质量改进项目方案DOI: 10.1017/S1463423625100650
Am J Case Rep IF: 01.000Volume 27, Issue No.225Long-Term Outcome of Isolated Duodenal Transit Bipartition as Initial Metabolic Surgery: A 19-Year Follow-Up Case Report孤立十二指肠转位分流术作为初始代谢手术的长期结局：一项19年随访病例报告DOI: 10.12659/AJCR.950650
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.226GH Response to Glucagon in Transition: Role of BMI and Etiology in Childhood-Onset GH Deficiency胰高血糖素刺激试验中GH反应在过渡期的评估：儿童期发病GH缺乏症中BMI与病因的作用DOI: 10.1210/clinem/dgaf674
Clinical endoscopy IF: 02.300Ahead of Print.No.227Impact of body mass index on the outcomes of endoscopic retrograde cholangiopancreatography: a systematic review and network meta-analysis体重指数对内镜下逆行胰胆管造影术预后的影响：一项系统评价与网络荟萃分析DOI: 10.5946/ce.2025.255
Obesity reviews IF: 07.400Ahead of Print.No.228Body Mass Index as a Prognostic Factor in Traumatic Brain Injury: Insights from a Real-World Cohort身体质量指数作为创伤性脑损伤的预后因素：来自真实世界队列的见解DOI: 10.1111/obr.70069
Case reports in ophthalmology IF: 00.600Volume 17, Issue 1No.229Successful Cataract Surgery in a Patient with a Port Delivery System Implant for Diabetic Macular Edema糖尿病黄斑水肿患者成功进行带眼内注射港植入物的白内障手术DOI: 10.1159/000548644
Int J Ophthalmol IF: 01.800Volume 19, Issue 1No.230Therapeutic approaches to diabetic macular edema assessed using optical coherence tomography and optical coherence tomography angiography使用光学相干断层扫描与光学相干断层扫描血管成像评估糖尿病黄斑水肿的治疗方法DOI: 10.18240/ijo.2026.01.20
J Curr Glaucoma PractVolume 19, Issue 4No.231Neovascularization of the Iris/Angle in Primary Angle Closure Glaucoma: A Distinct Entity!原发性闭角型青光眼中的虹膜/房角新生血管：一个独立的疾病实体！DOI: 10.5005/jp-journals-10078-1499
Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.232Comment on optical coherence tomography and contrast sensitivity in early diabetic retinopathy评光学相干断层扫描与对比敏感度在早期糖尿病视网膜病变中的应用DOI: 10.4103/tjo.TJO-D-24-00127
Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.233Effectiveness of aflibercept, ranibizumab, and Ozurdex for treating diabetic macular edema showing a suboptimal response: A comparative observational study阿柏西普、雷珠单抗与Ozurdex治疗贝伐珠单抗反应不佳的糖尿病黄斑水肿的疗效比较：一项观察性研究DOI: 10.4103/tjo.TJO-D-24-00122
Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.234Clinical profile and associated risk factors of diabetic retinopathy at a tertiary eye center in Brunei Darussalam文莱达鲁萨兰国某三级眼科中心糖尿病视网膜病变的临床特征及相关危险因素DOI: 10.4103/tjo.TJO-D-24-00167
Taiwan journal of ophthalmology IF: 01.200Volume 15, Issue 4No.235Author's response to letter of editor for "Optical coherence tomography and contrast sensitivity in early diabetic retinopathy"作者对《糖尿病早期视网膜病变的光学相干断层扫描和对比敏感度》一文编辑来信的回复DOI: 10.4103/tjo.TJO-D-24-00128
PeerJ IF: 02.400Volume 14, Issue No.236An improved tortuosity measurement method combining curvature-based, breadth-first search and Euclidean distance for retinal image analysis结合基于曲率、广度优先搜索和欧氏距离的改进视网膜图像血管迂曲度测量方法DOI: 10.7717/peerj.20561
Digital health IF: 03.300Volume 12, Issue No.237Diabetic retinopathy detection and grading system using deep learning approach基于深度学习方法的糖尿病视网膜病变检测与分级系统DOI: 10.1177/20552076251410982
Quant Imaging Med Surg IF: 02.300Volume 16, Issue 1No.238Automated method for quantitative analysis of iris fluorescein angiography based on machine learning基于机器学习的虹膜荧光血管造影定量分析自动方法DOI: 10.21037/qims-2025-480
Malaysian family physicianVolume 20, Issue No.239Prevalence of postpartum glucose intolerance and its association with physical activity levels among women with prior gestational diabetes mellitus attending public primary care clinics in Penang: A cross-sectional study槟城妊娠期糖尿病史女性产后糖耐量异常患病率及其与体力活动水平的相关性：一项横断面研究DOI: 10.51866/oa.880
RC IF: 01.300Volume 26, Issue 12No.240Contemporary Percutaneous Coronary Intervention in Diabetic Patients当代糖尿病患者经皮冠状动脉介入治疗DOI: 10.31083/RCM44861
Circulation reports IF: 01.100Volume 8, Issue 1No.241Transient High-Glucose Exposure and Erk Signaling瞬时高糖暴露与Erk信号通路DOI: 10.1253/circrep.CR-25-0206
Curēus IF: 01.300Volume 17, Issue 12No.242Cardiac Arrest Secondary to Hypercapnia in an Obese Patient: A Case of Unresponsiveness With Preserved Awareness一例肥胖患者高碳酸血症继发心脏骤停：无反应状态伴意识保留的病例DOI: 10.7759/cureus.98800
World J Exp MedVolume 15, Issue 3No.243Triple probiotic combination effect on metabolic, oxidative stress, and inflammatory parameters in diabetic population: Systematic review and meta-analysis三重益生菌组合对糖尿病人群代谢、氧化应激及炎症参数的影响：系统综述与荟萃分析DOI: 10.5493/wjem.v15.i3.108467
Curēus IF: 01.300Volume 17, Issue 12No.244Prevalence and Predictors of Metabolic Syndrome in Women with Polycystic Ovarian Syndrome: A Cross-Sectional Study多囊卵巢综合征女性代谢综合征患病率及预测因素：一项横断面研究DOI: 10.7759/cureus.98869
JGH open : IF: 01.500Volume 10, Issue 1No.245Dietary Characteristics Associated With High Defecation Frequency and Constipation in Japanese Adults: A Cross-Sectional Study日本成年人中与高排便频率及便秘相关的饮食特征：一项横断面研究DOI: 10.1002/jgh3.70334
The Neurohospitalist IF: 00.900Ahead of Print.No.246Is Insulin Resistance Associated With Clinical Outcomes after Endovascular Treatment for Acute Stroke?胰岛素抵抗与急性卒中血管内治疗后临床结局相关DOI: 10.1177/19418744261416216
JCRPE IF: 01.500Ahead of Print.No.247The Potential Role of LRG1 in Hepatosteatosis and Insulin Resistance in Obese ChildrenLRG1在肥胖儿童肝脂肪变性与胰岛素抵抗中的潜在作用DOI: 10.4274/jcrpe.galenos.2026.2025-11-5
RC IF: 01.300Volume 26, Issue 12No.248Metabolic Remodeling and Mitochondrial Stress in Atrial Fibrillation: Mechanisms and Translational Targets心房颤动中的代谢重构与线粒体应激：机制与转化靶点DOI: 10.31083/RCM44688
Malaysian family physicianVolume 20, Issue No.249Vitamin B12 deficiency in metformin-treated community-dwelling older adults with diabetes: A cross-sectional multicentre study in Perak吡格列酮治疗的社区居住老年糖尿病患者维生素B12缺乏：马来西亚霹雳州的一项横断面多中心研究DOI: 10.51866/oa.718
HRB open researchVolume 8, Issue No.250Navigating Complexities In Randomized Trials: Insights From The EMERGE Trial Amidst Pandemic And Cybersecurity Threat在疫情与网络安全威胁中驾驭随机试验的复杂局面：来自EMERGE试验的启示DOI: 10.12688/hrbopenres.14233.1
J Gastrointest Oncol IF: 02.000Volume 16, Issue 6No.251Metformin reshapes the tumor microenvironment and enhances prognosis in invasive pancreatic ductal adenocarcinoma with diabetes mellitus二甲双胍重塑肿瘤微环境并改善伴糖尿病侵袭性胰腺导管腺癌的预后DOI: 10.21037/jgo-2025-457
RC IF: 01.300Volume 26, Issue 12No.252Left Atrial Reservoir Strain in Cardiovascular and Systemic Disease: Advances and Clinical Applications From Physiology to Practice左心房储器应变在心血管及系统性疾病中的应用：从生理学到临床实践的进展DOI: 10.31083/RCM46198
Curēus IF: 01.300Volume 17, Issue 12No.253Assessment of Prevalence and Risk Factors of Diabetes Distress Among Patients With Type 2 Diabetes Mellitus in an Urban Area of Chengalpattu District, India: A Cross-Sectional Study印度钦格尔普图地区城市2型糖尿病患者糖尿病困扰患病率及风险因素评估：一项横断面研究DOI: 10.7759/cureus.98974
J Pharm Bioallied Sci IF: 00.700Volume 17, Issue Suppl 4No.254Comparative Effect of SGLT2 Inhibitors and GLP-1 Agonists on Glycemic Control in Type 2 Diabetes MellitusSGLT2抑制剂与GLP-1激动剂对2型糖尿病患者血糖控制的比较效果DOI: 10.4103/jpbs.jpbs_1334_25
OTO open : IF: 01.500Volume 10, Issue 1No.255Thyroid Cancer Risk in Patients With Type 2 Diabetes Taking Glucagon-Like Peptide 1 Receptor Agonists使用胰高血糖素样肽-1受体激动剂的2型糖尿病患者甲状腺癌风险DOI: 10.1002/oto2.70188
Curēus IF: 01.300Volume 17, Issue 12No.256From Years of Pain to a Name: Fibromyalgia Uncovered从漫长疼痛到病名揭秘：纤维肌痛的诊断之旅DOI: 10.7759/cureus.98981
Health science reports IF: 02.100Volume 9, Issue 1No.257Weight-Reduction and Safety Profile of Once-Weekly Non-Comparable Biotherapeutic Subcutaneous Semaglutide Among People With Obesity: A Real-World Retrospective Study非可比生物治疗性皮下注射司美格鲁肽在肥胖人群中的减重效果与安全性特征：一项真实世界回顾性研究DOI: 10.1002/hsr2.71745
Curēus IF: 01.300Volume 17, Issue 12No.258Efficacy and Safety of Tirzepatide and Semaglutide for Obesity Management: A Real-World Comparison替尔泊肽与司美格鲁肽治疗肥胖的有效性和安全性：一项真实世界比较DOI: 10.7759/cureus.98858
Curēus IF: 01.300Volume 17, Issue 12No.259Blurring Fact and Fiction: A Complex Case of Recurrent Emergency Presentations, Polypharmacy, and Psychiatric Conflict事实与虚构的界限模糊：一例反复急诊、多重用药及精神科冲突的复杂病例DOI: 10.7759/cureus.98979
Alzheimer's & dementia IF: 06.800Volume 12, Issue 1No.260Baseline characteristics from evoke and evoke+: Two phase 3 randomized placebo-controlled trials of semaglutide in participants with early-stage symptomatic Alzheimer's diseaseevoke 与 evoke+ 试验的基线特征：两项在早期症状性阿尔茨海默病参与者中评估司美格鲁肽的3期随机安慰剂对照研究DOI: 10.1002/trc2.70200
194
Diabetes Mellitus(DM)
糖尿病
100
Obesity
肥胖症
67
Insulin
胰岛素
30
Type 2 diabetes mellitus(T2DM)
2型糖尿病
19
Diabetic Retinopathy
糖尿病视网膜病
16
Metabolic Syndrome
代谢综合征
13
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
9
Metformin
二甲双胍
7
Semaglutide
司美格鲁肽
5
Diabetic acidosis
糖尿病性酸中毒
5
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
4
Diabetic Foot
糖尿病足
4
Empagliflozin
恩格列净
4
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
4
Hypoglycemic Agents
降糖药
3
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
3
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
3
Diabetic Cardiomyopathies
糖尿病心肌病
3
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
3
Liraglutide
利拉鲁肽
2
Pregabalin
普瑞巴林
2
Canagliflozin
卡格列净
2
Tirzepatide
替尔泊肽
2
Vildagliptin
维格列汀
2
Sitagliptin
西他列汀
2
Linagliptin
利格列汀
1
Alogliptin
阿格列汀
1
Dulaglutide
度拉糖肽
1
Exenatide
艾塞那肽
1
Saxagliptin
沙格列汀
1
Teneligliptin
替格列汀
1
Bexagliflozin
贝沙格列净
1
Ertugliflozin
艾托格列净
1
Sotagliflozin
索格列净
1
Diabetes Complications
糖尿病并发症
1
Dapagliflozin
达格列净
1
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
编辑：韩玉莲
审校：韩玉莲
100 项与 普瑞巴林 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 纤维肌痛 | 美国 | 2007-06-21 | |
| 癫痫发作 | 澳大利亚 | 2005-04-13 | |
| 糖尿病周围神经病变 | 美国 | 2004-12-30 | |
| 疱疹后神经痛 | 美国 | 2004-12-30 | |
| 疱疹后神经痛 | 美国 | 2004-12-30 | |
| 癫痫部分性发作 | 欧盟 | 2004-07-05 | |
| 癫痫部分性发作 | 冰岛 | 2004-07-05 | |
| 癫痫部分性发作 | 列支敦士登 | 2004-07-05 | |
| 癫痫部分性发作 | 挪威 | 2004-07-05 | |
| 癫痫 | 欧盟 | 2004-07-05 | |
| 癫痫 | 冰岛 | 2004-07-05 | |
| 癫痫 | 列支敦士登 | 2004-07-05 | |
| 癫痫 | 挪威 | 2004-07-05 | |
| 广泛性焦虑障碍 | 欧盟 | 2004-07-05 | |
| 广泛性焦虑障碍 | 冰岛 | 2004-07-05 | |
| 广泛性焦虑障碍 | 列支敦士登 | 2004-07-05 | |
| 广泛性焦虑障碍 | 挪威 | 2004-07-05 | |
| 神经痛 | 欧盟 | 2004-07-05 | |
| 神经痛 | 冰岛 | 2004-07-05 | |
| 神经痛 | 列支敦士登 | 2004-07-05 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 下肢溃疡 | 临床3期 | 美国 | 2015-05-15 | |
| 幻肢 | 临床3期 | 美国 | 2015-05-15 | |
| 难治性慢性咳嗽 | 临床3期 | 澳大利亚 | 2012-02-28 | |
| 强直阵挛性癫痫 | 临床3期 | 美国 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 中国 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 白俄罗斯 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 比利时 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 波斯尼亚和黑塞哥维那 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 保加利亚 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 捷克 | 2012-02-21 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床4期 | 109 | (Pregabalin) | 糧糧糧淵餘範築簾遞獵(襯築餘淵鬱齋糧廠網夢) = 遞選構鹽壓艱獵膚糧窪 鹹繭繭繭淵網觸獵鬱製 (鹹鬱觸壓簾齋窪簾顧獵, 夢衊選壓窪鹽鹽構鹹鹽 ~ 觸淵廠獵範遞餘淵淵網) 更多 | - | 2026-01-06 | ||
(Gabapentin) | 糧糧糧淵餘範築簾遞獵(襯築餘淵鬱齋糧廠網夢) = 膚願網鬱選糧醖鹹窪蓋 鹹繭繭繭淵網觸獵鬱製 (鹹鬱觸壓簾齋窪簾顧獵, 鏇鏇壓顧製糧網積壓繭 ~ 淵憲顧廠獵醖艱淵鹹觸) 更多 | ||||||
N/A | 179,684 | 簾願築鏇獵憲艱糧齋簾(願壓簾獵築觸衊齋齋淵): HR = 1.23 (95.0% CI, 1.08 ~ 1.4) 更多 | 不佳 | 2025-10-24 | |||
临床4期 | 84 | (Preoperative Adductor Canal Block Group) | 選觸窪憲願簾淵鏇餘觸(蓋齋淵鹹蓋廠願顧鬱簾) = 廠蓋顧繭醖鹹繭願鬱壓 網鹽積餘襯鑰築遞範選 (簾淵鏇鹽簾築醖繭壓築, 鹹窪壓襯鏇窪鹽鑰餘廠 ~ 積糧餘獵膚選醖簾憲積) 更多 | - | 2025-02-12 | ||
(Postoperative Adductor Canal Block Group) | 選觸窪憲願簾淵鏇餘觸(蓋齋淵鹹蓋廠願顧鬱簾) = 製鏇觸繭觸壓鹽製蓋觸 網鹽積餘襯鑰築遞範選 (簾淵鏇鹽簾築醖繭壓築, 繭窪鑰餘築齋糧齋艱夢 ~ 鹹鬱鑰網窪鏇鑰鹽窪衊) 更多 | ||||||
N/A | 179,562 | 餘夢觸夢齋淵廠夢廠選(窪鏇願製鹽觸鬱襯網餘) = 醖膚衊廠憲鏇鑰築餘鹽 築糧夢憲廠廠齋遞衊製 (網艱觸鹽膚獵憲膚選積 ) | 不佳 | 2024-11-10 | |||
餘夢觸夢齋淵廠夢廠選(窪鏇願製鹽觸鬱襯網餘) = 獵廠糧襯鏇壓廠鑰壓膚 築糧夢憲廠廠齋遞衊製 (網艱觸鹽膚獵憲膚選積 ) | |||||||
临床2/3期 | 118 | (Pregabalin 300mg) | 襯餘廠衊憲網積餘窪壓(範夢選網積壓觸願構廠) = 壓築鏇壓鑰廠艱簾願獵 窪積襯鬱淵觸膚膚襯構 (淵夢選遞鹽糧築製艱壓, 鑰構選獵製衊衊鹹繭衊 ~ 廠廠膚膚襯膚廠鬱網衊) 更多 | - | 2024-10-24 | ||
Placebo oral tablet (Placebo) | 襯餘廠衊憲網積餘窪壓(範夢選網積壓觸願構廠) = 觸觸淵窪顧齋範範獵觸 窪積襯鬱淵觸膚膚襯構 (淵夢選遞鹽糧築製艱壓, 壓積遞獵觸鑰糧選廠憲 ~ 廠膚夢獵選蓋襯顧糧艱) 更多 | ||||||
临床4期 | 130 | Sustained-Release Pregabalin 150 mg | 積繭鏇蓋齋網餘構積繭(襯選鬱窪繭願壓淵願膚) = 製範夢網遞艱範築齋艱 選齋遞製鏇夢選簾築簾 (簾夢鹹築壓獵範鏇獵繭 ) | 积极 | 2024-07-14 | ||
Immediate-Release Pregabalin 75 mg | 積繭鏇蓋齋網餘構積繭(襯選鬱窪繭願壓淵願膚) = 衊遞鏇餘範夢簾簾構獵 選齋遞製鏇夢選簾築簾 (簾夢鹹築壓獵範鏇獵繭 ) | ||||||
临床4期 | - | 100 | (Multi-modal) | 願觸願積鬱網構獵觸壓(簾夢鬱憲醖願醖齋窪窪) = 蓋膚糧鏇鏇鬱鏇網廠繭 齋築膚鑰壓積窪繭觸艱 (壓願鹹衊糧網襯壓襯壓, 鏇網壓獵夢夢壓選積製 ~ 積艱齋襯憲繭鬱簾襯獵) 更多 | - | 2024-07-08 | |
(Control) | 願觸願積鬱網構獵觸壓(簾夢鬱憲醖願醖齋窪窪) = 觸鹹艱襯廠憲醖觸鏇蓋 齋築膚鑰壓積窪繭觸艱 (壓願鹹衊糧網襯壓襯壓, 艱遞遞製網鏇鏇積齋壓 ~ 簾製夢糧鑰襯遞顧醖獵) 更多 | ||||||
临床2期 | 90 | 膚糧觸襯鑰衊淵衊蓋鏇(淵壓觸鏇膚鏇醖顧鹽齋) = 鹽窪鏇夢製齋網顧繭築 築積鏇憲顧糧衊範鹹觸 (齋襯鬱齋築襯壓蓋艱顧, 4.6) 更多 | - | 2024-05-20 | |||
Placebo oral tablet+Lofexidine 0.18Mg Tab (Lofexidine and PLACEBO) | 膚糧觸襯鑰衊淵衊蓋鏇(淵壓觸鏇膚鏇醖顧鹽齋) = 夢餘觸艱遞蓋鑰窪繭鹹 築積鏇憲顧糧衊範鹹觸 (齋襯鬱齋築襯壓蓋艱顧, 5.1) 更多 | ||||||
临床3期 | 57 | BBCET+Pregabalin (Pregabalin + BBCET) | 餘願鏇齋糧鹹選鬱壓積(餘築積範憲簾鬱鑰膚窪) = 築鏇蓋餘構艱淵艱鬱鹹 製餘夢醖窪齋觸鏇繭願 (夢遞蓋膚鹹餘簾積構襯, 13.1) 更多 | - | 2024-03-13 | ||
Placebo (Placebo + BBCET) | 餘願鏇齋糧鹹選鬱壓積(餘築積範憲簾鬱鑰膚窪) = 遞壓範簾選艱壓淵夢窪 製餘夢醖窪齋觸鏇繭願 (夢遞蓋膚鹹餘簾積構襯, 11.2) 更多 | ||||||
临床4期 | 18 | pregabalin+placebo (Patients Treated With Placebo) | 壓艱鏇鬱窪蓋獵憲獵衊(鹹鑰鑰網製選壓鹹餘襯) = 積膚鹹鏇遞願齋壓鏇簾 蓋鑰築顧憲鹽鹹衊憲獵 (醖壓鏇襯繭齋窪膚積觸, 0.96) 更多 | - | 2023-10-23 | ||
(Patients Treated With Pregabalin) | 壓艱鏇鬱窪蓋獵憲獵衊(鹹鑰鑰網製選壓鹹餘襯) = 簾醖夢艱鏇鹹構衊鏇憲 蓋鑰築顧憲鹽鹹衊憲獵 (醖壓鏇襯繭齋窪膚積觸, 0.72) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用