预约演示
更新于：2026-05-02
Pregabalin
普瑞巴林
更新于：2026-05-02
概要
基本信息
简介普瑞巴林，商品名为 Lyrica®，是一种众所周知的抗惊厥药物，已在各种疾病的治疗中找到立足之地。 这些病症包括但不限于焦虑症、癫痫和神经痛。普瑞巴林的作用机制包括阻断 CACNA2D1、CACNA2D2钙通道，从而有效地治疗这些疾病。Upjohn Co. 早在 2004 年就在欧盟获得了普瑞巴林的医疗用途批准，并已在市场上应用。普瑞巴林的适应症主要针对神经性疼痛病症如纤维肌痛，与其他抗惊厥药物联合用于治疗部分发作性癫痫。由于普瑞巴林可最大限度地减少伴随症状，因此可以使用普瑞巴林来控制这些病症。 因此，普瑞巴林是治疗慢性疼痛和神经系统疾病的重要措施。 |
药物类型 小分子化药 |
别名 LYRICA CR、CI-1008、GLA5PR + [13] |
作用方式 阻滞剂 |
作用机制 CACNA2D1阻滞剂(电压门控性钙通道α2/δ亚基-1阻滞剂)、CACNA2D2阻滞剂(电压门控性钙通道α2/δ亚基-2阻滞剂) |
非在研适应症 |
原研机构 |
在研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C8H17NO2 |
InChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-N |
CAS号148553-50-8 |
关联
1,039
项与 普瑞巴林 相关的临床试验NCT07549490
A Pilot Study for Developing a Comprehensive Signal Detection Approach for the Mechanisms of Action and Analgesic Efficacy of Two Analgesics Using Human Experimental Models of Pain (HEMP)
This pilot study will test an innovative way to establish how pain medicines provide analgesia in healthy adults. The study uses a group of short, controlled pain tests to look at different types of pain responses in the body. The main goal is to find out if this testing approach can show the pain-relieving effects of 2 medicines, pregabalin and naproxen versus placebo, and show how they provide relief of different types of pain.
The study hypothesis is that this pain testing approach administered as a battery would be able to tell the difference between a medicine that works mainly in the brain and spinal cord (pregabalin) and a medicine that works mainly on inflammation in body tissues (naproxen).
Up to 25 healthy adults will take part. Each participant will receive all 3 study treatments, pregabalin, naproxen, and placebo, administered in random order during separate study periods. The order will be assigned by chance. Neither the participant nor the study team will know which treatment is given at each visit.
The study includes several experimental pain tests. These include:
a heat and capsaicin skin test that causes short-term skin sensitivity,
a UVB light test that causes a temporary sunburn-like sensitivity, and
a cold pressor test, in which a hand is placed in very cold water for a short time.
Participants will also have sensory testing to measure how they feel touch, pressure, pinprick, warmth, heat, and cold. Blood samples will be collected to measure study drug levels. Urine samples, vital signs, and other safety checks will also be done.
Each treatment visit includes testing before and for several hours after taking the study drug. There will be a washout period of at least 48 hours between treatments. Total participation may last up to about 10 weeks.
This study is not expected to provide direct medical benefit to participants. The information learned may help researchers improve early testing of future pain treatments....
The study hypothesis is that this pain testing approach administered as a battery would be able to tell the difference between a medicine that works mainly in the brain and spinal cord (pregabalin) and a medicine that works mainly on inflammation in body tissues (naproxen).
Up to 25 healthy adults will take part. Each participant will receive all 3 study treatments, pregabalin, naproxen, and placebo, administered in random order during separate study periods. The order will be assigned by chance. Neither the participant nor the study team will know which treatment is given at each visit.
The study includes several experimental pain tests. These include:
a heat and capsaicin skin test that causes short-term skin sensitivity,
a UVB light test that causes a temporary sunburn-like sensitivity, and
a cold pressor test, in which a hand is placed in very cold water for a short time.
Participants will also have sensory testing to measure how they feel touch, pressure, pinprick, warmth, heat, and cold. Blood samples will be collected to measure study drug levels. Urine samples, vital signs, and other safety checks will also be done.
Each treatment visit includes testing before and for several hours after taking the study drug. There will be a washout period of at least 48 hours between treatments. Total participation may last up to about 10 weeks.
This study is not expected to provide direct medical benefit to participants. The information learned may help researchers improve early testing of future pain treatments....
开始日期2026-06-15 |
NCT07456761
Effect of Low-dose Pregabalin Retard (82.5 mg) Versus Standard-dose Pregabalin Retard (165 mg) on Postoperative Pain and Opioid Consumption After Elective Laparoscopic Abdominal Surgery: a Randomized, Double-blind, Controlled Trial
The goal of this clinical trial is to detect whether pregabalin retard (82.5 mg or 165 mg) improves analgesia after elective laparoscopic abdominal surgery in adults. It will also evaluate the safety of both doses.
The main questions it aims to answer are:
Does the higher dose (165 mg) reduce the total amount of opioids needed in the first 24 hours after surgery compared to the lower dose (82.5 mg)? Do the pain scores differ between the two doses? Are there differences in side effects between the two doses?
Researchers will compare two different doses of pregabalin retard to determine which provides better pain control with fewer side effects.
Participants will:
Take one dose of pregabalin retard (82.5 mg or 165 mg) before surgery Receive standard anesthesia and multimodal pain treatment Have their pain levels and opioid use monitored for 24 hours after surgery Be assessed for side effects such as dizziness, nausea, or sedation
The main questions it aims to answer are:
Does the higher dose (165 mg) reduce the total amount of opioids needed in the first 24 hours after surgery compared to the lower dose (82.5 mg)? Do the pain scores differ between the two doses? Are there differences in side effects between the two doses?
Researchers will compare two different doses of pregabalin retard to determine which provides better pain control with fewer side effects.
Participants will:
Take one dose of pregabalin retard (82.5 mg or 165 mg) before surgery Receive standard anesthesia and multimodal pain treatment Have their pain levels and opioid use monitored for 24 hours after surgery Be assessed for side effects such as dizziness, nausea, or sedation
开始日期2026-04-01 |
申办/合作机构- |
NCT07288528
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough (FORTITUDE)
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory assessment of potential synergy in combining these interventions, and the long-term outcomes of these treatments in patients with refractory or unexplained chronic cough.
开始日期2026-04-01 |
申办/合作机构 |
100 项与 普瑞巴林 相关的临床结果
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100 项与 普瑞巴林 相关的转化医学
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100 项与 普瑞巴林 相关的专利（医药）
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5,676
项与 普瑞巴林 相关的文献（医药）2026-12-31·COPD-Journal of Chronic Obstructive Pulmonary Disease
Prescribing Patterns of Gabapentinoids in Patients with Chronic Obstructive Pulmonary Disorder
Article
作者: Bullock, Reece ; Dimit, Alexandra ; Patel, Manysha ; Englehart, Anika ; King, Olivia ; Soric, Mate Michael ; Bole, Kelly ; Mara, Nita ; Vergara, Mollie ; Moqbl, Amgad ; Skory, Brandon
In 2019, the U.S. Food and Drug Administration (FDA) issued a warning regarding the risk of serious respiratory depression in patients using gabapentin or pregabalin who have respiratory risk factors, including those with chronic obstructive pulmonary disorder (COPD). With the overall prescribing of gabapentinoids continuing to grow, there is the potential for inappropriate prescribing in this patient population. Data from the National Ambulatory Medical Care Survey (NAMCS) from 2013 to 2018, with the exception of 2017, was used to assess prevalence and predictors of gabapentinoid prescribing in patients with COPD. The data consists of 1,131 unweighted visits, representing approximately 53.6 million ambulatory care visits nationally. Of these visits, 146 patients (10.8%) with a COPD diagnosis were also prescribed a gabapentinoid, which represents more than a million office visits annually when weighted. Patients with an increased risk of receiving gabapentinoids were those with concomitant diabetes mellitus, concurrent opioid use, and those currently using tobacco. Due to increased risk of serious respiratory depression caused by gabapentinoids, prescribers should take caution when prescribing to individuals with COPD and other respiratory risk factors. Based on the reviewed prescribing patterns, more education is needed to inform providers about the risks associated with concomitant COPD and gabapentinoid use.
2026-07-01·FORENSIC SCIENCE INTERNATIONAL
Investigation of the utility of vitreous humour drug concentrations when compared to peripheral blood using the National Programme on Substance Use Mortality database
Article
作者: Morley, S R ; Copeland, C S
Peripheral blood (PB) remains the standard matrix for postmortem toxicological analysis, yet its interpretive reliability is often compromised by postmortem redistribution (PMR), trauma, or decomposition. Vitreous humour (VH), due to its anatomical isolation and reduced susceptibility to PMR, has emerged as a promising alternative matrix. This study investigates the correlation between VH and PB drug concentrations using data from the National Programme on Substance Use Mortality (NPSUM), aiming to enhance interpretive accuracy and forensic utility of VH. A total of 110 cases with paired VH and PB drug concentrations were identified. Quantitative toxicology data were extracted from coronial submissions across the UK, with analysing laboratories accredited by UKAS or an international equivalent. Statistical comparisons were performed using Wilcoxon signed-rank tests and coefficients of determination (R²) to assess correlation strength. Drug concentrations were consistently lower in VH than PB, yet all drugs detected in PB were also present in VH. Strong correlations were observed for pregabalin (R²=0.86), methadone (R²=0.81), gabapentin (R²=0.76), and codeine (R²=0.70), while cocaine (R²=0.56) showed moderate correlation. Weak correlations were noted for BZE (R²=0.44), EDDP (R²=0.20), and morphine (R²=0.19). These findings suggest that VH concentrations reflect systemic levels for certain drugs, particularly those with limited PMR and favourable physicochemical properties. The study highlights VH's value as a confirmatory matrix, especially when PB is unavailable. However, the variability in VH-PB correlations underscores the need for matrix-specific interpretive frameworks. Factors such as lipophilicity, protein binding, and molecular size appear to influence VH penetration more than PMR alone. This work represents one of the most comprehensive evaluations of VH-PB drug correlations to date and supports the development of a systematic reference database. Future research should expand case numbers and incorporate additional covariates to refine VH-based interpretive models. VH offers a viable alternative for postmortem toxicology, but its evidential weight depends on drug-specific characteristics and robust reference data.
2026-05-01·Sleep and Breathing
Placebo and nocebo responses in gabapentin enacarbil and pregabalin trials for restless legs syndrome: time-course model-based network meta-analysis and meta-analysis of proportions
Review
作者: Iftikhar, Imran H ; Lacki, Olga A ; Pedder, Hugo ; Albisher, Essa ; BaHammam, Ahmed S
701
项与 普瑞巴林 相关的新闻（医药）2026-05-01
·今日头条
你有没有过这样的绝望：带状疱疹的水泡早就消了，可皮肤一碰就像被烧红的烙铁烫过；糖尿病多年，手脚的刺痛麻木从指尖蔓延到胳膊腿，夜里疼得睡不着；化疗结束半年，手脚还是像戴了厚厚的冰手套，碰什么都觉得刺骨的凉。
医生告诉你这是 "
神经病理性疼痛（Neuropathic Pain）
"，开了一堆止痛药、抗抑郁药、抗癫痫药。可你吃了头晕、嗜睡、恶心、便秘，疼痛却只缓解了一点点。更绝望的是，医生说："这个病没法根治，只能长期吃药控制。"
难道神经痛真的是不治之症吗？难道我们只能忍受药物的副作用，在疼痛和麻木中度过余生吗？
近 20 年的研究成果，彻底推翻了 "神经痛只能全身吃药" 的传统观念，证实：
绝大多数外周神经痛的根源不在大脑，而在皮肤和外周神经的局部 "信号暴乱"
。我们不需要用药物 "
麻痹整个大脑
"，只需要在疼痛的局部，精准拆除那些 "失控的信号炸弹"，就能安全、高效地缓解疼痛。
这就是神经痛治疗的一场革命：从 "全身轰炸" 到 "精准狙击"，从 "对抗疼痛" 到 "修复紊乱"。今天，我们就用最通俗的语言，带你看懂局部外用治疗神经痛的科学原理、现有成果和未来方向。
一、为什么你的神经痛，吃药不管用？
在讲局部治疗之前，我们必须先搞清楚一个最核心的问题：为什么传统的口服止痛药，对神经痛效果这么差？
1. 你被骗了：神经痛根本不是 "神经断了"
从小到大，我们都被告知："神经痛就是神经受伤了，就像电线断了，信号乱传。"
这个比喻误导了我们几十年。
如果神经真的断了，你应该感觉不到任何疼痛，只会麻木。可神经痛患者的感受恰恰相反：不是没有感觉，而是感觉太过敏锐 —— 轻轻一碰就疼，风吹过就疼，甚至自己的衣服摩擦皮肤都疼。
最新的科学研究告诉我们：
神经病理性疼痛，不是神经 "断了"，而是神经 "疯了"
。
我们可以把身体的疼痛系统比作一个国家的 "边防预警体系"：
皮肤和黏膜是边境线
感觉神经末梢是边境岗哨
免疫细胞是边防军
角质形成细胞是城墙守卫
大脑是中央指挥部
正常情况下，岗哨（神经末梢）发现危险（比如烫伤、割伤），会拉响警报，通知边防军（免疫细胞）赶来消灭敌人、修复伤口。等危险解除，警报就会自动解除。
可当神经受到损伤时 —— 比如带状疱疹病毒破坏了神经、高血糖毒害了神经、化疗药物损伤了神经 —— 这套预警系统会发生一场可怕的 "全面叛乱"：
岗哨疯了
：没事就乱拉警报，明明没有危险，却天天喊 "敌人来了"
边防军敌我不分
：把正常的神经细胞当成敌人攻击
城墙守卫也跟着起哄
：不停地敲锣打鼓，放大警报信号
最后，整个边境地区陷入无休止的 "暴乱"，警报声日夜不停
这就是神经病理性疼痛的本质：
不是没有信号，而是信号太多、太乱、停不下来
。
2. 口服药的困境：用 "全国戒严" 解决 "边境暴乱"
传统的口服止痛药，是怎么工作的呢？
药物吃下去后，经过胃肠道吸收，进入血液循环，流遍全身。只有不到 1% 的药物能到达疼痛的局部，剩下 99% 的药物会进入大脑、心脏、肝脏、肾脏等其他器官。
这就像边境地区发生了暴乱，你不派维和部队去当地平息动乱，反而宣布全国戒严，让所有城市都进入紧急状态。结果是什么呢？
暴乱没有得到有效控制（疼痛缓解不佳）
全国人民的正常生活都被打乱了（全身副作用）
时间长了，大家都麻木了，真的有危险也反应不过来了（药物耐受和成瘾）
这就是为什么口服药治疗神经痛效果差、副作用大的根本原因：
它们用 "全身轰炸" 的方式，去解决一个 "局部问题"
。
更糟糕的是，很多口服药的作用靶点在大脑。它们不是消除疼痛的根源，而是让大脑 "感觉不到疼痛"。这就像中央指挥部把警报器的喇叭关了，可边境的暴乱还在继续，甚至愈演愈烈。
3. 局部治疗(Topical Treatment)的优势：精准 "维和"，回归进化本源
那什么才是正确的治疗方式呢？
答案很简单：
哪里疼，就治哪里
。
既然疼痛的根源在局部的 "信号暴乱"，我们就应该把药物直接送到暴乱的地方，精准平息动乱，恢复正常秩序。这就是局部外用治疗的核心思想。
从进化的角度看，这是最符合生命逻辑的治疗方式。35 亿年来，疼痛系统一直都是 "局部感知、局部反应" 的模式。单细胞生物遇到危险，就地防御；水螅的神经网，哪里受伤，哪里就启动修复；直到人类，我们的皮肤依然保留着完整的局部防御和修复能力。
局部外用治疗，就是回归了疼痛系统的进化本源。它不干扰大脑和其他器官的正常功能，只在疼痛的局部发挥作用，真正做到了 "精准、高效、安全"。
二、局部外用治疗的科学原理：拆除 "失控的信号炸弹"
要理解局部外用药物是怎么工作的，我们得先搞清楚，外周的 "信号暴乱" 到底是由哪些 "炸弹" 引起的。
外周神经痛的核心是
"神经 - 免疫 - 皮肤" 恶性正反馈循环
。这个循环中有四个关键的 "信号炸弹"，只要拆除其中任何一个，就能打破恶性循环，缓解疼痛。
1. 第一颗炸弹：异常放电的 "离子通道"
神经细胞是靠电信号传递信息的，而电信号的产生，依赖于细胞膜上的 "离子通道"—— 就像神经细胞的 "电路开关"。
正常情况下，这些开关只有在受到刺激时才会打开，产生电信号。可神经损伤后，神经细胞膜上的 ** 电压门控钠通道（Nav）** 会大量增加，尤其是 Nav1.7、Nav1.8 和 Nav1.9 这三个亚型。
这些多余的开关会导致神经细胞的 "电路短路"，即使没有任何刺激，也会自发产生电信号 —— 这就是我们之前说的 "岗哨乱拉警报"。
局部外用的钠通道阻滞剂（比如利多卡因）
，就是专门拆除这颗炸弹的工兵。它们能穿透皮肤，到达神经末梢，堵住那些异常开放的钠通道，阻止神经细胞自发放电。
这就像给疯掉的岗哨的对讲机断电，让他们没法再乱发警报。正常的神经功能不会受到影响，因为正常的钠通道数量很少，不会被完全阻断。
2. 第二颗炸弹：过度敏感的 "温度探测器"
我们的神经末梢上有一种叫
TRPV1
的离子通道，它是我们的 "高温和辣椒素探测器"。正常情况下，只有温度超过 43℃或者吃到辣椒时，它才会被激活，让我们产生灼热感。
可神经损伤后，TRPV1 通道会大量增加，并且变得异常敏感。正常体温（37℃）就能激活它，让我们产生火烧火燎的疼痛感。这就是为什么很多神经痛患者总觉得皮肤 "发烫"，即使摸起来是凉的。
高浓度辣椒素贴剂
，就是针对这颗炸弹的 "特种部队"。辣椒素是 TRPV1 通道的天然激动剂，高浓度的辣椒素会让过度兴奋的 TRPV1 通道暂时 "耗竭"—— 就像让过度劳累的哨兵下岗休息几个月。
一次贴敷 8% 辣椒素贴剂，能让 TRPV1 通道失活 3-6 个月，期间疼痛会显著缓解。虽然贴敷时会有一过性的烧灼感，但这是通道被激活的正常反应，很快就会消失。
3. 第三颗炸弹：持续释放的 "炎症因子"
神经损伤后，免疫细胞会被招募到损伤部位，释放大量的炎症因子，比如 TNF-α、IL-1β、PGE2 等。这些炎症因子就像 "兴奋剂"，会进一步敏化神经末梢上的离子通道，让神经更加兴奋。
同时，神经末梢也会释放 P 物质、CGRP 等神经肽，反过来激活更多的免疫细胞，释放更多的炎症因子。这就形成了一个
"神经 - 免疫恶性循环
"：神经越兴奋，免疫细胞越活跃；免疫细胞越活跃，神经越兴奋。
局部外用的非甾体抗炎药（比如双氯芬酸）
，就是用来拆除这颗炸弹的。它们能抑制环氧合酶（COX-2）的活性，减少前列腺素 E2（PGE2）的合成，从而减轻局部炎症，打破神经 - 免疫恶性循环。
4. 第四颗炸弹：异常耦联的 "交感神经"
最神奇的是，神经损伤后，负责 "战斗 - 逃跑" 反应的交感神经，会异常长入感觉神经节。这就像把 "情绪开关" 接到了警报器上：你一紧张、一焦虑、一生气，警报器就会响。
很多患者说 "越疼越烦，越烦越疼"，就是这个道理。交感神经释放的去甲肾上腺素，会激活感觉神经上的 α1 - 肾上腺素能受体，进一步加重疼痛。
局部外用的 α1 - 受体阻滞剂（比如哌唑嗪）
，就是专门切断这根 "错误电线" 的电工。它们能阻断去甲肾上腺素的作用，打断交感神经和感觉神经之间的异常耦联，让情绪不再影响疼痛。
三、局部外用治疗的现状：哪些方法已经被证实有效？
经过近 30 年的研究，局部外用治疗已经从 "非主流" 变成了国际指南推荐的一线治疗方案。目前，已经有多种药物和技术被证实对神经痛有效，并且副作用极小。
1. 一线首选：5% 利多卡因贴剂
5% 利多卡因贴剂是目前国际指南
最高级别推荐
的局部外用药物，也是治疗局限性神经痛的首选。
它的原理非常简单：通过皮肤渗透，释放利多卡因，阻断神经末梢上的异常钠通道，阻止异位放电。它不会麻痹正常的感觉，也不会进入大脑，所以没有头晕、嗜睡、成瘾等副作用。
临床研究显示，5% 利多卡因贴剂对
带状疱疹后神经痛、糖尿病周围神经痛、创伤后神经痛
都有显著疗效。大约 50-60% 的患者疼痛能缓解 50% 以上，并且起效快，贴敷后 1-2 小时就能感觉到疼痛减轻。
更重要的是，它的安全性极高。即使长期使用，也不会产生耐受和依赖。很多患者用了十几年，效果依然很好。唯一的缺点是可能会引起局部皮肤发红、瘙痒，但通常都很轻微，不影响继续使用。
2. 长效止痛：8% 辣椒素贴剂
8% 辣椒素贴剂是另一种被国际指南推荐的一线药物，特别适合那些对利多卡因效果不好的患者。
它的作用机制比较特殊：通过激活 TRPV1 通道，导致通道脱敏和神经末梢暂时失活。一次贴敷 30-60 分钟，止痛效果能持续 3-6 个月。这意味着，你只需要每 3-6 个月贴一次，就能长期缓解疼痛。
临床研究显示，8% 辣椒素贴剂对带状疱疹后神经痛的有效率约为 40-50%，对糖尿病周围神经痛的有效率约为 35-45%。它的主要副作用是贴敷部位的一过性烧灼感和红斑，通常在贴敷后 1-3 天内消失。为了减轻不适感，医生通常会在贴敷前给患者使用局部麻醉剂。
3. 多靶点干预：肉毒素 A
肉毒素 A（BTX-A）大家都很熟悉，它是一种常用的美容除皱药物。但很多人不知道，它还是治疗神经痛的 "神器"。
肉毒素 A 的作用机制非常独特：它能阻断神经末梢释放乙酰胆碱和多种神经肽（比如 P 物质、CGRP），从而切断神经和免疫细胞之间的通讯，打破 "神经 - 免疫 - 皮肤" 恶性循环。
一次局部注射肉毒素 A，止痛效果能持续 3-6 个月。临床研究显示，它对
带状疱疹后神经痛、三叉神经痛、复杂区域疼痛综合征
都有显著疗效，有效率约为 50-70%。
它的副作用非常轻微，可能会引起注射部位的短暂疼痛、红肿，或者局部肌肉无力，但通常会在几周内自行恢复。和口服药相比，肉毒素 A 的优势是长效、安全、没有全身副作用。
4. 其他常用的局部外用药物
除了上述三种一线药物，临床上还有很多其他的局部外用药物，虽然证据级别稍低，但在某些患者中也能取得很好的效果：
加巴喷丁乳膏 / 普瑞巴林乳膏
：阻断电压门控钙通道，减少神经递质释放，对多种神经痛有效。
氯胺酮乳膏
：阻断 NMDA 受体，对难治性神经痛有一定效果。
可乐定乳膏
：激活 α2 - 肾上腺素能受体，抑制交感神经活性，缓解灼痛和交感神经介导的疼痛。
阿米替林乳膏
：三环类抗抑郁药，阻断钠通道和 NMDA 受体，对神经痛有一定疗效。
这些药物通常作为二线或三线治疗，用于那些对一线药物效果不好的患者，或者和一线药物联合使用，增强疗效。
5. 现有疗法的局限性
虽然局部外用治疗取得了很大的进步，但它并不是万能的，仍然存在一些局限性：
有效率有限
：即使是最好的药物，有效率也只有 50-60%，还有大约 40% 的患者效果不佳。
不能根治
：目前的局部治疗只能缓解症状，不能修复受损的神经，所以需要长期维持治疗。
皮肤渗透性问题
：很多药物很难穿透皮肤的角质层，到达深层的神经末梢。
个体差异大
：不同患者对同一种药物的反应差异很大，需要个体化治疗。
这些局限性，正是未来研究需要解决的问题。
四、未来的方向：精准医疗时代的 "神经痛拆弹专家"
随着分子生物学和药物研发技术的进步，局部外用治疗正在进入一个全新的 "精准医疗" 时代。未来的神经痛治疗，将不再是 "千人一方"，而是根据每个患者的具体发病机制，定制个性化的治疗方案。
1. 新一代分子靶点：更精准的 "拆弹工具"
目前的局部药物，大多是 "多靶点" 药物，它们会同时作用于多种离子通道和受体，所以不可避免地会有一些副作用。未来的药物研发，将朝着 "高选择性、单靶点" 的方向发展，开发出更精准、更安全的 "拆弹工具"。
（1）Nav1.7/1.8 特异性抑制剂
Nav1.7 和 Nav1.8 是只在感觉神经末梢表达的钠通道亚型，它们是神经病理性疼痛的核心靶点。如果能开发出只阻断这两个亚型，而不影响其他钠通道的药物，就能在完全止痛的同时，不影响正常的感觉和运动功能。
目前，已经有多种 Nav1.7/1.8 特异性抑制剂进入临床试验阶段。其中，TV-45070 在带状疱疹后神经痛的临床试验中显示出了良好的疗效和安全性。未来，这些药物有望成为新一代的局部外用止痛药。
（2）TRP 通道调节剂
除了 TRPV1，TRP 通道家族还有很多其他成员参与了疼痛的发生，比如 TRPA1、TRPM8、TRPV4 等。针对这些靶点的调节剂，正在成为研究的热点。
例如，TRPA1 拮抗剂能缓解冷痛和化学性疼痛，TRPM8 激动剂能缓解灼痛。未来，我们可以根据患者的疼痛类型（灼痛、刺痛、冷痛），选择不同的 TRP 通道调节剂，实现精准治疗。
（3）神经肽抑制剂
P 物质和 CGRP 是两种重要的疼痛神经肽，它们在神经源性炎症和疼痛敏化中发挥着关键作用。目前，CGRP 单克隆抗体已经成为治疗偏头痛的一线药物，取得了巨大的成功。
未来，局部外用的 CGRP 抗体或受体拮抗剂，有望用于治疗神经病理性疼痛。它们能精准阻断神经肽的作用，打破神经 - 免疫恶性循环，而且不会产生全身副作用。
（4）免疫靶点
越来越多的研究表明，免疫细胞和炎症因子在神经痛的发生和维持中起着至关重要的作用。未来，针对免疫靶点的局部治疗，将成为一个新的研究方向。
例如，局部外用的 TNF-α 抑制剂、IL-1β 抑制剂，能精准抑制局部炎症，缓解疼痛。这些药物已经在类风湿性关节炎等炎症性疾病中取得了成功，未来有望用于神经痛的治疗。
2. 透皮给药技术革命：让药物精准到达 "战场"
局部外用药物最大的瓶颈，就是皮肤的角质层 —— 它像一道坚固的城墙，阻止了大多数药物的渗透。未来，透皮给药技术的革命，将彻底打破这个瓶颈，让药物能够精准到达深层的神经末梢。
（1）微针技术
微针是一种由数十到数百个微米级的细小针头组成的贴片。这些针头能穿透皮肤的角质层，形成微小的通道，让药物直接进入真皮层，到达神经末梢。
微针技术的优势非常明显：
无痛、微创，不会引起出血和感染
大大提高药物的渗透效率，减少药物用量
可以实现药物的控释和缓释，延长作用时间
目前，微针给药系统已经在胰岛素、疫苗等药物的递送中取得了成功。未来，载有利多卡因、辣椒素、肉毒素等药物的微针贴片，将成为神经痛治疗的新利器。
（2）物理促渗技术
除了微针，还有很多物理方法可以促进药物的透皮吸收，比如离子导入、超声导入、电穿孔、激光打孔等。
离子导入是利用电场的作用，将带电的药物分子导入皮肤；超声导入是利用超声波的空化效应，增加皮肤的通透性。这些技术能让那些原本很难穿透皮肤的大分子药物（比如抗体、蛋白质），也能通过局部外用的方式给药。
（3）纳米载体技术
纳米载体是一种直径在 1-1000 纳米之间的微小颗粒，它能包裹药物分子，穿透皮肤的角质层，到达深层组织。
纳米载体的优势是：
提高药物的溶解度和稳定性
实现药物的靶向递送，减少对正常组织的影响
控制药物的释放速度，延长作用时间
目前，已经有多种纳米载体系统进入临床试验阶段，比如脂质体、纳米乳、聚合物纳米粒等。未来，载有多种药物的纳米载体，将实现 "多靶点同时打击"，大大提高神经痛的治疗效果。
3. 细胞治疗和基因治疗：从 "缓解症状" 到 "根治疾病"
目前的局部治疗只能缓解症状，不能修复受损的神经。未来，细胞治疗和基因治疗的发展，有望让我们从根本上治愈神经病理性疼痛。
（1）间充质干细胞治疗
间充质干细胞（MSC）是一种具有多向分化潜能的成体干细胞，它能分泌多种神经营养因子和抗炎因子，促进神经再生，减轻局部炎症。
局部注射间充质干细胞，已经在动物实验中显示出了良好的治疗效果。它能促进受损神经的修复，逆转神经敏化，从根本上消除疼痛。目前，已经有多项临床试验正在进行中，初步结果令人鼓舞。
（2）局部基因治疗
基因治疗是通过将正常的基因导入细胞，修复异常的基因表达，从而治疗疾病。对于神经病理性疼痛，我们可以通过局部基因治疗，下调异常表达的离子通道（比如 Nav1.7、TRPV1），或者上调抑制性神经递质的表达。
例如，通过病毒载体将阿片肽基因导入局部神经末梢，让神经末梢持续分泌内源性阿片肽，就能长期缓解疼痛，而且不会产生全身副作用。目前，局部基因治疗已经在动物实验中取得了成功，未来有望成为根治神经痛的终极手段。
4. 联合治疗：多管齐下，全面 "平叛"
神经病理性疼痛是一种多机制、多因素的疾病，单一靶点的治疗往往效果有限。未来的治疗趋势，是
多靶点、多模式的联合治疗
。
例如：
利多卡因贴剂 + 辣椒素贴剂：同时阻断钠通道和 TRPV1 通道，增强止痛效果
局部外用药物 + 口服药物：局部治疗解决外周问题，口服药物解决中枢敏化问题
药物治疗 + 神经调控：比如局部外用药物联合经皮神经电刺激（TENS），进一步提高疗效
药物治疗 + 心理治疗：缓解焦虑和抑郁，打断 "疼痛 - 情绪" 恶性循环
通过多管齐下的联合治疗，我们可以针对每个患者的具体情况，制定个性化的治疗方案，最大限度地缓解疼痛，提高患者的生活质量。
五、给神经痛患者的建议：如何正确使用局部外用治疗？
虽然局部外用治疗安全有效，但很多患者因为使用方法不当，导致效果不佳。在这里，我给大家提几点实用的建议：
1. 早发现，早治疗
神经痛治疗的黄金时间是
发病后的 3 个月内
。在这个阶段，疼痛主要是由外周敏化引起的，还没有发展成中枢敏化。及时使用局部外用药物，打断外周的恶性循环，就能有效防止疼痛慢性化，甚至完全治愈。
很多患者抱着 "忍一忍就过去了" 的想法，结果拖成了慢性疼痛，治疗起来就非常困难了。如果你有神经损伤的病史，并且出现了持续的疼痛、麻木、感觉异常，一定要及时去医院的疼痛科就诊。
2. 选择合适的药物
不同的局部药物，针对的疼痛类型不同：
如果你是
持续性的灼痛、刺痛
，可以首选 5% 利多卡因贴剂
如果你是
阵发性的闪电痛、刀割痛
，可以尝试 8% 辣椒素贴剂
如果你是
情绪相关的疼痛
，可以尝试可乐定乳膏
如果你有明显的
炎症表现
（红肿、发热），可以尝试双氯芬酸凝胶
如果一种药物效果不好，可以换用另一种，或者联合使用两种不同机制的药物。不要因为一种药物无效，就放弃局部治疗。
3. 正确使用药物
局部外用药物的使用方法非常重要，直接影响疗效：
贴剂
：要贴在疼痛最明显的部位，皮肤要清洁干燥。不要贴在破损、发炎的皮肤上。每贴可以贴 12-24 小时，然后取下，间隔 12 小时再贴下一贴，避免皮肤刺激。
乳膏 / 凝胶
：要均匀涂抹在疼痛部位，轻轻按摩至完全吸收。每天涂抹 3-4 次，坚持使用，不要疼了才涂。
肉毒素注射
：要由专业的疼痛科医生操作，注射在疼痛的部位。注射后不要按摩注射部位，避免药物扩散。
4. 不要排斥联合治疗
如果局部外用药物效果不够好，可以联合口服药物、神经调控、物理治疗等其他方法。不要觉得 "外用药没用"，也不要觉得 "吃药就不用外用药了"。联合治疗能发挥协同作用，提高疗效，减少口服药的用量，降低副作用。
5. 保持耐心和信心
神经病理性疼痛是一种慢性疾病，治疗需要时间。很多患者用了几天药，觉得效果不好，就放弃了。其实，很多局部药物需要连续使用 2-4 周才能达到最佳效果。
请保持耐心和信心，和你的医生密切配合，找到最适合你的治疗方案。随着医学的进步，越来越多的新疗法正在涌现，神经痛不再是不治之症。
结语：一场正在发生的医学革命
从 "全身吃药" 到 "局部拆弹"，从 "对抗疼痛" 到 "修复紊乱"，神经痛治疗正在经历一场深刻的革命。这场革命的核心，是我们对疼痛本质的理解发生了根本性的改变。
我们曾经以为，疼痛是大脑的感觉，所以要治疗大脑。现在我们知道，绝大多数外周神经痛的根源在局部，在皮肤和外周神经的 "信号暴乱"。我们不需要麻痹大脑，只需要在局部精准拆除那些失控的信号炸弹。
这场革命，不仅给数亿神经痛患者带来了希望，也改变了我们对医学的理解。最好的治疗，不是用药物去对抗身体，而是顺着生命的逻辑，帮助身体恢复正常的秩序。
35 亿年来，疼痛系统一直是我们最忠诚的守护者。它偶尔会失控，会犯错，但它的初衷永远是保护我们。治疗慢性疼痛，不是要消灭疼痛，而是要和这个古老的系统和解，帮它关掉失灵的警报，让它重新回到正确的轨道。
终有一天，我们会彻底驯服这个失控的 "边防预警系统"，让每一个神经痛患者都能摆脱疼痛的折磨，重新拥有正常的生活。而这场从 "全身轰炸" 到 "精准狙击" 的医学革命，正在我们眼前，一步步变成现实。
Kocot-Kępska M, Zajączkowska R, Mika J, Wordliczek J, Dobrogowski J, Przeklasa-Muszyńska A. Peripheral Mechanisms of Neuropathic Pain-the Role of Neuronal and Non-Neuronal Interactions and Their Implications for Topical Treatment of Neuropathic Pain. Pharmaceuticals (Basel). 2021 Jan 20;14(2):77. doi: 10.3390/ph14020077. PMID: 33498496; PMCID: PMC7909513.
Kocot-Kępska M, Zajączkowska R, Mika J, Kopsky DJ, Wordliczek J, Dobrogowski J, Przeklasa-Muszyńska A. Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain-Narrative Review. Pharmaceutics. 2021 Mar 26;13(4):450. doi: 10.3390/pharmaceutics13040450. PMID: 33810493; PMCID: PMC8067282.
疼痛 "暴乱" 发生的三层战场
** 皮肤（SKIN）** 的三层结构，这正是外周神经痛的核心 "战场"，每一层都有参与 "信号暴乱" 的关键角色：
表格
皮肤分层
对应角色
功能
暴乱时的表现
角质形成细胞层（KERATINOCYTES）
城墙守卫
构成皮肤屏障，正常时参与温和触觉和屏障修复
神经损伤后，大量表达痛觉受体，持续释放疼痛信号，放大警报
外周神经末梢层（PERIPHERAL NERVE ENDINGS）
边防岗哨
感知外界刺激，传递正常感觉信号
离子通道异常增生，自发产生电信号，把 "触摸" 误传为 "剧痛"
免疫细胞层（IMMUNOCOMPETENT CELLS）
边防军
清除病原体，修复损伤
持续激活，释放大量炎症因子，进一步敏化神经末梢，形成恶性循环
图中不同颜色的小点，就是分布在这三类细胞上的
痛觉相关靶点
—— 也就是我们要拆除的 "信号炸弹"。
10 个核心 "拆弹靶点" 与对应药物
图上方的 10 个箭头，代表了目前临床和研究中最成熟的局部治疗靶点。每个靶点都有对应的药物类型（激动剂 / 阻滞剂 / 配体），我们可以把它们理解为
不同类型的 "拆弹工具"
：
1. 离子通道类靶点（最核心的 "电路炸弹"）
这类靶点是神经细胞产生电信号的 "开关"，神经损伤后会大量增生，导致 "电路短路、乱发电"。
Nav blocker（电压门控钠通道阻滞剂）
对应药物：5% 利多卡因贴剂（一线首选）、阿米替林乳膏、苯妥英乳膏
作用：堵住异常开放的钠通道，阻止神经末梢自发放电，相当于
给疯掉的岗哨断电
分布：神经末梢 + 角质形成细胞，双重作用增强止痛效果
TRPV1 ligand（TRPV1 通道配体）
对应药物：8% 辣椒素贴剂（一线推荐）
作用：高浓度辣椒素会过度激活并耗竭 TRPV1 通道（高温 / 辣椒素探测器），让过度劳累的 "岗哨" 暂时下岗休息 3-6 个月
分布：神经末梢 + 角质形成细胞 + 免疫细胞
VGCC blocker（电压门控钙通道阻滞剂）
对应药物：加巴喷丁乳膏、普瑞巴林乳膏
作用：阻断钙通道，减少神经递质释放，相当于
切断岗哨的对讲机信号
分布：神经末梢 + 角质形成细胞
NMDAR blocker（NMDA 受体阻滞剂）
对应药物：氯胺酮乳膏
作用：阻断谷氨酸介导的痛觉信号放大，相当于
降低警报器的音量
分布：神经末梢 + 角质形成细胞 + 免疫细胞
2. 受体类靶点（"通讯信号炸弹"）
这类靶点是细胞之间传递信号的 "接收器"，神经损伤后会异常敏感，放大疼痛信号。
GABAR agonist（GABA 受体激动剂）
对应药物：巴氯芬乳膏
作用：激活抑制性 GABA 受体，给过度兴奋的神经 "踩刹车"
分布：三类细胞均有表达
α1, α2 AR ligand（肾上腺素能受体配体）
对应药物：哌唑嗪乳膏（α1 阻滞剂）、可乐定乳膏（α2 激动剂）
作用：切断交感神经与感觉神经的异常耦联，相当于
拆掉 "情绪开关" 和 "警报器" 之间的错误电线
，缓解情绪相关的疼痛
分布：三类细胞均有表达
OR agonist（阿片受体激动剂）
对应药物：吗啡凝胶、洛哌丁胺乳膏
作用：激活外周阿片受体，局部止痛，
不会进入大脑，无成瘾风险
分布：神经末梢 + 角质形成细胞 + 免疫细胞
CB agonist（大麻素受体激动剂）
对应药物：CBD 乳膏、棕榈酰乙醇胺（PEA）乳膏
作用：激活 CB1/CB2 受体，抑制炎症和痛觉信号，相当于
给边防军下达 "停火令"
分布：三类细胞均有表达
3. 酶类靶点（"炎症炸弹"）
这类靶点是产生炎症因子的 "工厂"，神经损伤后会过度活跃，持续制造炎症。
COX-2 blocker（环氧合酶 - 2 阻滞剂）
对应药物：双氯芬酸凝胶、布洛芬凝胶 作用：抑制前列腺素合成，减轻局部炎症，打破神经 - 免疫恶性循环 分布：神经末梢 + 免疫细胞
4. 突触蛋白类靶点（"神经递质释放炸弹"）
SNAP-25 ligand（SNAP-25 蛋白配体）
对应药物：肉毒素 A（BTX-A） 作用：切割 SNAP-25 蛋白，阻断神经末梢释放乙酰胆碱和疼痛神经肽（P 物质、CGRP），相当于
彻底切断岗哨的通讯线路
，一次注射止痛 3-6 个月 分布：神经末梢 + 免疫细胞
2026-05-01
·iReg
太阳当空照，花儿对我笑。
小鸟说：“早早早，你为什么背上小书包？”
我要上学校，天天不迟到。
爱学习，爱劳动，
长大要为人民立功劳
五一劳动节，新鲜出炉的iReg法规七龙珠（五一长假大礼包）送给“爱学习，爱劳动”的你——法规更新至2026年4月30日，一共1689个文件，压缩包约786MB，下载链接：
https://pan.baidu.com/s/1XHgHFrEFJEe5_85GUnXPMA?pwd=iReg
说明：
一、法规更新至2026年4月30日，包含如下13条新法规：
20260402_NMPA_国家药监局关于“人工智能+药品监管”的实施意见
20260402_NMPA_《国家药监局关于“人工智能+药品监管”的实施意见》政策解读
20260402_NMPA_关于做好生物制品分段生产有关工作的通知
20260403_CDE_关于修订发布《药物研发与技术审评沟通交流管理办法》的通告（2026年第28号）
20260408_CDE_关于发布《药物临床试验申请临床评价技术指导原则》的通告（2026年第27号）
20260408_CDE_关于发布《药物上市申请临床评价技术指导原则》的通告（2026年第26号）
20260410_NMPA_药品说明书适老化及无障碍改革试点名单（第六批）
20260413_CDE_关于发布《以患者为中心的中药新药临床研发技术指导原则》的通告（2026年第29号）
20260420_CDE_关于发布《治疗用重组蛋白药物首次申报临床试验药学资料撰写指导原则》等3个文件的通告（2026年第30号）
20260420_NMPA_关于进一步加强普瑞巴林等药品管理的通告（2026年第11号）
20260420_NMPA_关于印发《允许药材进口口岸现场评估标准及检查细则》的通知
20260423_CDE_关于发布《上市后变更补充申请事项及受理时启动注册检验情形的说明表》的通知
20260424_NMPA_关于发布药品附条件批准上市申请审评审批工作程序的公告（2026年第41号）
二、NMPA发布的参比制剂更新至第104批，CDE公示的参比制剂征求意见稿更新至第106批（每批征求意见稿的附件3为未通过审议品种目录，审议未通过原因可以作为企业的“避坑指南”），所有批次参比制剂目录合并为一个PDF并添加书签便于浏览，详见“6. 特别专题\6.3 仿制药一致性评价\6.3.4 参比制剂公示”：
三、法规命名规则为“发布日期+发布机构+法规名称”，如“20250718_CDE_化学药品口溶膜剂药学研究技术指导原则（试行）”，压缩包随附的txt文件为发布机构英文缩写及全称；
四、法规一般为官网网页内容和附件的结合，官网网页采用浏览器打印的方式另存为PDF，与附件合并。大部分PDF文件都添加了书签便于导览，如果默认没有显示书签，请点击Adobe Acrobat Reader或Adobe Acrobat Pro左侧的书签图标显示书签；
五、《iReg法规七龙珠》属于免费分享的参考资料，所有法规来源于中国官方网站，仅用于学习与交流，请勿作他用；
六、汇编人员名单如下：
1. 通用法规：jiandanlong、小旭、寓言、小格
2. 药物临床试验申请法规：jiandanlong
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7. 指导原则：大兵、寓言
七、iReg魔法书中的《iReg法规七龙珠》也已经更新至最新版本，大家通过手机应用市场安装腾讯ima之后，可以随时查阅、搜索和AI问答，欢迎大家试用体验（提问示例请参考iReg魔法书药品注册16问）：
2026-04-30
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至04月30日15点59分，近期共有 579 本期刊发布了 1148 篇文章，其中糖尿病相关的文章共 344 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 109 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Wound repair and regeneration IF: 03.400 糖尿病足溃疡住院后30天再入院：一项全国性分析
Sanaka, Krishna O, Mitra, Nandita, Margolis, David J, etc.
糖尿病足溃疡是糖尿病成人住院的常见原因，与高发病率和死亡率相关。住院后再入院仍然常见，但描述再入院模式和驱动因素的全国代表性证据有限。
这项回顾性队列研究使用了2022年美国全国再入院数据库，旨在描述30天全因再入院率，识别与再入院相关的因素，并比较美国糖尿病足溃疡住院成人的指标住院和再入院情况。通过诊断代码识别诊断为糖尿病足溃疡的成人住院，并进行调查加权分析以生成全国估计。
在估计的234,797次初始住院中，13.3%的患者在30天内再入院，超过了全国住院患者平均水平8.2%。再入院患者中肾脏疾病、心血管疾病和精神健康状况的患病率更高。多变量分析显示，肾脏疾病、心血管合并症、烟草使用、药物使用障碍和双相情感障碍与再入院风险增加相关。相反，初始住院期间的感染相关诊断和手术，包括骨感染、手术清创和下肢截肢，与再入院风险降低相关。再入院住院时间更长，急性全身性疾病患病率更高。
这些发现表明，糖尿病足溃疡住院后早期再入院主要由全身性医疗不稳定驱动，而非局部感染复发，强调了多学科住院和出院后护理策略的必要性。
本文由 韩玉莲 编辑
扫描二维码查看源文
Wound repair and regeneration | Volume 34, Issue 3
10.1111/wrr.70165
02 Journal of diabetes IF: 03.700 糖尿病神经病变的人口统计学和临床特征：来自2012-2017年韩国国民健康保险服务的数据
Jeong, Su Jin, Kim, Sun Keun, Kim, Chong Hwa, etc.
糖尿病神经病变（DN）是2型糖尿病（T2DM）最常见的慢性并发症，既往研究报告的患病率在23%至54.5%之间。本研究利用韩国国民健康保险服务（NHIS）2012年至2017年的数据，评估了DN的患病率、临床特征及治疗情况。
研究分析了NHIS样本数据中870万按年龄、性别、资格和收入分层的人群。DN的定义采用ICD-10编码（E10.4-E14.4, G59.0, G63.2, G99.0）以及同时开具糖尿病和DN处方的标准。计算了糖尿病患者中每年的DN患病率，并比较了有和无DN患者的治疗模式及患者特征。
结果显示，DN患病率从2012年的23.4%下降至2017年的21.5%。约半数DN患者接受了药物治疗，其中单药治疗比例高达82%，二联治疗占15%，三联治疗占3%。最常处方的药物是α-硫辛酸（52.1%-55.0%），其次是抗惊厥药（30.4%-34.5%）、三环类抗抑郁药、SNRIs和γ-亚麻酸。DN患者通常年龄较大，女性居多，且合并症更多，如高血压、血脂异常、心血管疾病、糖尿病足和截肢。他们更可能使用胰岛素或多种口服降糖药。
结论指出，约四分之一的T2DM患者患有DN，其中半数接受了治疗，主要为α-硫辛酸单药治疗。DN患者往往年龄较大且合并多种疾病，导致住院率更高。
本文由 天纳乾坤 编辑
扫描二维码查看源文
Journal of diabetes | Volume 18, Issue 5
10.1111/1753-0407.70196
03 JAMA dermatology IF: 11.000 美国国家银屑病基金会关于GLP-1受体激动剂治疗银屑病的入门指南：综述
Samip Sheth, Joseph F. Merola, Brittany N. Weber, Ronald Prussick, Jensen Yeung, Clive Liu, etc.
美国国家银屑病基金会医学委员会近日在《JAMA dermatology》上发表了一篇综述，为皮肤科医生介绍了GLP-1受体激动剂（GLP-1 RAs）在银屑病治疗中的应用。
银屑病是一种慢性免疫介导疾病，常伴有心血管、代谢、肌肉骨骼、精神、肝脏、肾脏和肺部共病。GLP-1 RAs已获美国食品药品监督管理局批准用于2型糖尿病、肥胖、心血管风险降低、慢性肾脏病、阻塞性睡眠呼吸暂停和代谢功能障碍相关脂肪性肝炎，这些疾病在银屑病患者中常见。新出现的证据表明，GLP-1 RAs和双重葡萄糖依赖性促胰岛素多肽/GLP-1激动剂可能通过免疫调节改善银屑病皮损。如果在大规模随机临床试验中得到证实，基于GLP-1的疗法可能为同时治疗皮肤疾病和心血管代谢共病提供机会。
综述的观察部分指出，GLP-1 RAs与银屑病面积和严重程度指数（PASI）评分降低相关，尤其在肥胖或2型糖尿病患者中。研究报告PASI相对降低约40%至80%，同时生活质量改善，但大多数研究规模较小（7-48例患者）、短期（≤6个月）且缺乏对照组。司美格鲁肽和利拉鲁肽与C反应蛋白、白细胞介素-6、血脂和内脏脂肪减少相关。在小型转化队列中，PASI改善与浅表脂肪和真皮γδ T细胞密度减少相关。GLP-1 RAs可与甲氨蝶呤、环孢素和生物制剂安全联用。不良反应主要为短暂胃肠道症状，胰腺炎和胆囊事件罕见。早期数据显示代谢和免疫调节双重益处。
综述结论认为，基于GLP-1的疗法靶向银屑病中共享的代谢和炎症通路。当前证据支持在选定的代谢共病患者中考虑辅助使用，但最终结论尚需更大规模随机临床试验证实。
本文由 韩玉莲 编辑
扫描二维码查看源文
JAMA dermatology | Ahead of Print.
10.1001/jamadermatol.2026.0859
04 Frontiers in endocrinology IF: 04.600 糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析
Fan, Seng, Gai, Ziyue, Ma, Hui, Wen, Ziye, Ma, Chunlei, Fan, Dongying, etc.
一项发表于《Frontiers in Endocrinology》的荟萃分析系统评估了糖尿病视网膜病变（DR）与焦虑、抑郁之间的双向关系。研究共纳入34项观察性研究，涉及383,195例患者，覆盖14个国家。
结果显示，DR患者发生抑郁的风险显著高于非DR患者（OR=1.58，95%CI:1.24-2.02，P<0.001）；反之，抑郁患者发生DR的风险也显著升高（OR=2.13，95%CI:1.53-2.98，P<0.001），提示两者存在双向关系。此外，DR患者发生焦虑的风险是非DR患者的2.23倍（95%CI:1.07-4.68，P=0.033）。
亚组分析表明，研究设计、地区和混杂因素可能是异质性的来源。敏感性分析显示结果总体稳健，但存在发表偏倚。
研究建议，在DR的临床治疗中应重视患者的心理状态，实施个性化心理护理，以改善患者预后。
本文由 韩玉莲 编辑
扫描二维码查看源文
Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1764745
中国发表（109）
China
Scientific reports IF: 03.900Ahead of Print.No.01A case control study of subjective sleep characteristics and polycystic ovary syndrome主观睡眠特征与多囊卵巢综合征的病例对照研究DOI: 10.1038/s41598-026-50477-3
Complement Ther Clin Pract IF: 03.000Ahead of Print.No.02Effect of acupoint catgut embedding therapy on polycystic ovary syndrome: a systematic review and meta-analysis穴位埋线疗法对多囊卵巢综合征有效性的系统评价与Meta分析DOI: 10.1016/j.ctcp.2026.102056
Journal of hazardous materials IF: 11.300Ahead of Print.No.03Biomarker-anchored screening of dietary microplastics via a gut microbiota-informed machine learning model基于肠道微生物组信息的机器学习模型实现膳食微塑料的生物标志物锚定筛查DOI: 10.1016/j.jhazmat.2026.142219
Chung-Hua Wai K'o Tsa ChihAhead of Print.No.04[Define benchmarks for low-risk sleeve gastrectomy: based on the greater China metabolic and bariatric surgery database]低风险袖状胃切除术的基准定义：基于大中华区减重代谢手术数据库DOI: 10.3760/cma.j.cn112139-20251110-00525
Orthopaedic surgery IF: 02.100Ahead of Print.No.05Research Progress on Risk Factors for Acute Kidney Injury After Antibiotic-Loaded Bone Cement Spacer Treatment for Periprosthetic Joint Infection抗生素骨水泥间隔物治疗假体周围感染后急性肾损伤危险因素的研究进展DOI: 10.1111/os.70327
Mol Cell Endocrinol IF: 03.600Ahead of Print.No.06Adiponectin ameliorates chronic-intermittent-hypoxia-induced insulin resistance by modulating macrophage inflammation in visceral white adipose tissue脂联素通过调节内脏白色脂肪组织巨噬细胞炎症改善慢性间歇性缺氧诱导的胰岛素抵抗DOI: 10.1016/j.mce.2026.112809
Biomaterials advances IF: 06.000Ahead of Print.No.07A upper critical solution temperature- and synergistic antioxidant-responsive tremella polysaccharide hydrogel for enhancing diabetic wound healing一种上临界溶解温度和协同抗氧化响应的银耳多糖水凝胶促进糖尿病伤口愈合DOI: 10.1016/j.bioadv.2026.214900
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.08Association Between Maternal Diabetes and the Risk of Cancers in Mother-Offspring: A Meta-Analysis of 44.9 Million Pregnancies母亲糖尿病与母子癌症风险的关联：一项基于4490万妊娠的荟萃分析DOI: 10.1111/dom.70835
Scientific data IF: 06.900Ahead of Print.No.09Chinese Food Images for Full-cycle Nutrition Analysis Towards Diabetes Management面向糖尿病管理的全周期营养分析的中餐图像数据集DOI: 10.1038/s41597-026-07334-9
Endocrine journal IF: 02.100Ahead of Print.No.10Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting糖尿病中可溶性肿瘤坏死因子受体：风险感知与受体靶向策略DOI: 10.1507/endocrj.EJ26-0050
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.11Letter to the editor-The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study致编辑的信——估计葡萄糖利用率对美国≥60岁非糖尿病人群全因和心血管死亡率的预测价值：一项基于人群的队列研究DOI: 10.1016/j.dsx.2026.103419
Talanta IF: 06.100Ahead of Print.No.12A novel time-gated luminescent ruthenium(II) complex probe for highly sensitive detection of methylglyoxal in foods and complex biological samples一种新型时间门控发光钌(II)配合物探针用于食品和复杂生物样品中甲基乙二醛的高灵敏检测DOI: 10.1016/j.talanta.2026.129907
Environmental research IF: 07.700Ahead of Print.No.13Long-term exposure to ambient PM(2.5) constituents and risk of microvascular complications among individuals with type 2 diabetes mellitus: a nationwide cohort study in UK长期暴露于环境PM2.5组分与2型糖尿病患者微血管并发症风险：一项英国全国性队列研究DOI: 10.1016/j.envres.2026.124589
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.14Correlation between fundus color and retinal microcirculation in Type 2 Diabetes Mellitus patients2型糖尿病患者眼底颜色与视网膜微循环的相关性DOI: 10.1016/j.pdpdt.2026.105493
Ophthalmology IF: 09.500Ahead of Print.No.15Decoding Gene-Lifestyle Synergy in Diabetic Retinopathy Development: A Transethnic Prospective Cohort Study解码糖尿病视网膜病变发展中的基因-生活方式协同作用：一项跨种族前瞻性队列研究DOI: 10.1016/j.ophtha.2026.04.017
Biomedizinische Technik IF: 01.800Ahead of Print.No.16RetinalFRNet: retinal vessel segmentation in OCTA images using the feature reconstruction networkRetinalFRNet：利用特征重建网络在OCTA图像中进行视网膜血管分割DOI: 10.1515/bmt-2026-0107
Bioorganic chemistry IF: 04.700Ahead of Print.No.17Puerarin alleviates type 2 diabetes by targeting AKT1 to inhibit ferroptosis: Integrating network pharmacology, proteomics and experimental validation葛根素通过靶向AKT1抑制铁死亡缓解2型糖尿病：网络药理学、蛋白质组学与实验验证的整合研究DOI: 10.1016/j.bioorg.2026.109915
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.18Vildagliptin alleviates cardiomyocyte apoptosis and inflammatory responses in the treatment of non-valvular atrial fibrillation by regulating the NO/sGC/cGMP signaling pathway维格列汀通过调节NO/sGC/cGMP信号通路减轻非瓣膜性心房颤动中的心肌细胞凋亡和炎症反应DOI: 10.1080/08923973.2026.2639559
Cell reports. Methods IF: 04.500Ahead of Print.No.19Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization非模式细菌的多维整合建模鉴定阿卡波糖生物合成优化的工程靶点DOI: 10.1016/j.crmeth.2026.101426
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.20Corrigendum to "Integrative pharmacology reveals the mechanisms of Erzhi Pill, a traditional Chinese formulation, against diabetic cardiomyopathy" [J. Ethnopharmacol., 296, (2022), 115474]对《整合药理学揭示传统中药方剂二至丸抗糖尿病心肌病的作用机制》[J. Ethnopharmacol., 296, (2022), 115474]的勘误DOI: 10.1016/j.jep.2026.121734
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.21Metabolomic signatures of hepatic steatosis reveal heterogeneity in cardiometabolic risk and responses to lifestyle interventions in type 2 diabetes: a post hoc analysis肝脏脂肪变性的代谢组学特征揭示2型糖尿病中心血管代谢风险及生活方式干预反应的异质性：一项事后分析DOI: 10.1186/s12933-026-03194-0
ACS nano IF: 16.000Ahead of Print.No.22Self-Cascading Copper-Based Nanoassemblies Trigger Bacterial Cuproptosis-Like Death and Promote Wound Healing for Diabetic Drug-Resistant Bacterial Infections自级联铜基纳米组装体触发细菌铜死亡样死亡并促进糖尿病耐药细菌感染的伤口愈合DOI: 10.1021/acsnano.5c21619
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.23Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast CancerUSP1抑制剂的设计与合成：与PARP抑制剂在三阴性乳腺癌中的协同抗肿瘤活性DOI: 10.1021/acs.jmedchem.5c03804
ACS nano IF: 16.000Ahead of Print.No.24Clinically Validated Leptin Receptor as a Target for Liposomal Delivery of Metformin in Endometriosis Therapy临床验证的瘦素受体作为脂质体递送二甲双胍治疗子宫内膜异位症的靶点DOI: 10.1021/acsnano.5c18417
Gait & posture IF: 02.400Ahead of Print.No.25Multi-modal sensor fusion in smart footwear to capture altered gait dynamics in patients with diabetic peripheral neuropathy: System validation and clinical applications智能鞋具多模态传感器融合捕捉糖尿病周围神经病变患者步态动力学改变：系统验证与临床应用DOI: 10.1016/j.gaitpost.2026.110196
PloS one IF: 02.600Volume 21, Issue 4No.26Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism蒿甲醚改善1型糖尿病肝损伤及相关的线粒体超微结构和中心碳代谢缺陷DOI: 10.1371/journal.pone.0348214
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 4No.27Metformin: Historical Origins, Mechanisms of Action, and Emerging Clinical Applications二甲双胍：历史起源、作用机制及新兴临床应用DOI: 10.1002/dmrr.70171
Science progress IF: 02.900Volume 109, Issue 2No.28Leukocyte VCS parameters as potential auxiliary markers associated with diabetes and its inflammatory complications: A retrospective cross-sectional study白细胞VCS参数作为糖尿病及其炎症并发症潜在辅助标志物的回顾性横断面研究DOI: 10.1177/00368504261445505
Am J Chin Med IF: 05.500Ahead of Print.No.29Acupuncture for Neuropathic Pain: Mechanisms, Clinical Efficacy and Future Perspectives针灸治疗神经病理性疼痛：机制、临床有效性及未来展望DOI: 10.1142/S0192415X26500254
Future science OA IF: 02.100Volume 12, Issue 1No.30Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis眼科糖基化与糖化研究图谱：一项符合PRISMA规范的文献计量与共引分析DOI: 10.1080/20565623.2026.2663167
International wound journal IF: 02.500Volume 21, Issue 2No.31Analysis of pathogen distribution and associated risk factors for surgical site infections following laparoscopic urological surgeries腹腔镜泌尿外科手术后手术部位感染的病原体分布及相关危险因素分析DOI: 10.1111/iwj.14721
Annals of hematology IF: 02.400Volume 105, Issue 5No.32Low dose of sitagliptin: effectively prevent liver aGVHD and accelerate neutrophil engraftment低剂量西格列汀：有效预防肝脏急性移植物抗宿主病并加速中性粒细胞植入DOI: 10.1007/s00277-026-07036-7
Minerva anestesiologica IF: 02.800Ahead of Print.No.33Efficacy of intranasal insulin in preventing postoperative delirium and its impact on insulin resistance in elderly non-cardiac surgical patients: a systematic review and meta-analysis鼻内胰岛素预防老年非心脏手术患者术后谵妄的有效性及其对胰岛素抵抗的影响：系统评价与荟萃分析DOI: 10.23736/S0375-9393.26.19719-3
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.34Clinical Efficacy of Continuous Nursing Plus Shared Outpatient Care on Remission of Type 2 Diabetes Mellitus延续性护理联合共享门诊管理对2型糖尿病缓解的临床有效性DOI: 10.31083/BJHM49861
Clin Pharmacol Drug Dev IF: 01.800Volume 15, Issue 5No.35Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects二甲双胍/吡格列酮片在空腹和进食条件下的比较药代动力学和生物等效性评估：一项在中国健康受试者中开展的随机研究DOI: 10.1002/cpdd.70063
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.36Clinical Value of High-Channel 12-Lead Holter in Assisting Early Identification of Arrhythmias in High-Risk Populations高通道12导联动态心电图在高危人群心律失常早期识别中的临床价值DOI: 10.31083/BJHM52968
JAHA IF: 05.300Ahead of Print.No.37Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study葡萄糖稳态的适应性负荷、表观遗传生物标志物与全因及心血管死亡：一项前瞻性队列研究DOI: 10.1161/JAHA.125.047287
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.38ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNAZFP36L1通过减少FTO介导的ACSL1 mRNA N6-甲基腺苷去甲基化增强缺血性卒中中的小胶质细胞铁死亡DOI: 10.1002/kjm2.70212
International wound journal IF: 02.500Volume 21, Issue 2No.39RETRACTED: The effect of placing drains and no drains after caesarean section in obese patients on patients' post-operative wound complications: A meta-analysis已撤回：肥胖患者剖宫产后放置引流管与不放置引流管对术后伤口并发症影响的荟萃分析DOI: 10.1111/iwj.14576
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Gut microbiome dysbiosis in PCOS: from pathogenesis to microbiome-targeted therapies多囊卵巢综合征中的肠道微生物群失调：从发病机制到微生物靶向治疗DOI: 10.3389/fendo.2026.1747766
BMC public health IF: 03.600Ahead of Print.No.41Associations between multiple air pollutants and insulin resistance in Chinese adults: the moderating role of physical activity多种空气污染物与中国成年人胰岛素抵抗的关联：体力活动的调节作用DOI: 10.1186/s12889-026-27595-8
Reprod Biol Endocrinol IF: 04.700Volume 24, Issue 1No.42Editorial expression of concern: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK编辑关注声明：白藜芦醇通过激活AMPK缓解小鼠妊娠期糖尿病DOI: 10.1186/s12958-026-01560-x
Fayixue zazhiVolume 42, Issue 1No.43[Synthetic Drug： Pregabalin]合成药物：普瑞巴林DOI: 10.12116/j.issn.1004-5619.2026.360302
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.44Correlation between the expression levels of miR-199a-3p and FN1 in serum and aqueous humor and the severity of type 2 diabetic retinopathy in a Chinese population中国人群中血清和房水中miR-199a-3p与FN1表达水平与2型糖尿病视网膜病变严重程度的相关性DOI: 10.1186/s12886-026-04838-1
BMC endocrine disorders IF: 03.300Ahead of Print.No.45The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis抗阻训练改善2型糖尿病β细胞功能的作用：系统综述与荟萃分析DOI: 10.1186/s12902-026-02286-y
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.46Extracellular vesicles inherit lactate from aggregated MSCs to alleviate type 1 diabetes mellitus via H(2)S-induced CD8(+) T cell exhaustion细胞外囊泡继承聚集间充质干细胞的乳酸通过H2S诱导CD8+ T细胞耗竭缓解1型糖尿病DOI: 10.1186/s12951-026-04466-3
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.47The associations of systemic inflammation and insulin resistance-related indicators with psychopathology and BDNF in patients with chronic schizophrenia慢性精神分裂症患者全身炎症和胰岛素抵抗相关指标与精神病理学及BDNF的关联DOI: 10.3389/fpsyt.2026.1802167
Frontiers in neurology IF: 02.800Volume 17, Issue No.48Beyond BMI: independent and opposing effects of overweight and obesity and triglycerides on 90-day functional outcomes after acute ischemic stroke超越体重指数：超重与肥胖和甘油三酯对急性缺血性卒中后90天功能结局的独立且相反的影响DOI: 10.3389/fneur.2026.1782157
Frontiers in immunology IF: 05.900Volume 17, Issue No.49Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders从免疫代谢角度靶向调控脂肪组织巨噬细胞：肥胖相关代谢性疾病的新治疗策略DOI: 10.3389/fimmu.2026.1803488
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.50Association between stress hyperglycemic ratio and stroke in older people with metabolic syndrome: a prospective cohort study from UK Biobank应激性高血糖比率与代谢综合征老年人群卒中风险的关联：一项来自英国生物样本库的前瞻性队列研究DOI: 10.3389/fendo.2026.1758847
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.51Endocrine-informed monitoring of scoliosis in Prader-Willi syndrome: integrating neuroendocrine pathophysiology, growth hormone therapy, and pubertal transitionPrader-Willi综合征脊柱侧弯的内分泌指导监测：整合神经内分泌病理生理学、生长激素治疗与青春期过渡DOI: 10.3389/fendo.2026.1803919
FCVM IF: 02.900Volume 13, Issue No.52Efficacy and safety of levosimendan in acute heart failure patients with different body mass index: a multicenter, retrospective, observational real-world study左西孟旦在不同体重指数急性心力衰竭患者中的有效性和安全性：一项多中心、回顾性、观察性真实世界研究DOI: 10.3389/fcvm.2026.1790085
Frontiers in nutrition IF: 05.100Volume 13, Issue No.53The correlation between nutrition index scores and nutrition status of preschool children in a district of Shanghai上海市某区学龄前儿童营养指数评分与营养状况的相关性研究DOI: 10.3389/fnut.2026.1746871
Frontiers in nutrition IF: 05.100Volume 13, Issue No.54Associations of umbilical cord vitamin D levels with childhood cardiometabolic risks: a longitudinal mother-child study脐带维生素D水平与儿童期心脏代谢风险的关联：一项纵向母婴研究DOI: 10.3389/fnut.2026.1777909
Frontiers in nutrition IF: 05.100Volume 13, Issue No.55Fasting blood glucose to high-density lipoprotein cholesterol ratio and MASLD risk: non-linear association and BMI mediation in non-diabetic adults空腹血糖与高密度脂蛋白胆固醇比值与非糖尿病成人脂肪性肝病风险的非线性关联及体重指数的中介作用DOI: 10.3389/fnut.2026.1818931
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.56Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus妊娠期糖尿病孕妇孕中期甘油三酯-葡萄糖指数及其衍生指数对巨大儿的预测价值DOI: 10.2147/DMSO.S577687
J Int Med Res IF: 01.500Volume 54, Issue 4No.57A metabolic-inflammatory phenotype of pelvic floor dysfunction: A machine learning-based cross-sectional study in a nationally representative US population盆底功能障碍的代谢炎症表型：一项基于机器学习、具有全国代表性的美国人群横断面研究DOI: 10.1177/03000605261438949
J Int Med Res IF: 01.500Volume 54, Issue 4No.58Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study抑郁患者人体测量指标与死亡风险的关联：一项基于人群的队列研究DOI: 10.1177/03000605261442794
Am J Respir Cell Mol Biol IF: 05.300Ahead of Print.No.59FTO Alleviates COPD Pathogenesis by Demethylating S100A9 to Suppress ERK1/2-Drp1-Driven MitophagyFTO通过去甲基化S100A9抑制ERK1/2-Drp1驱动的线粒体自噬减轻COPD发病机制DOI: 10.1093/ajrcmb/aanag094
Diabetology & metabolic syndrome IF: 03.900Volume 18, Issue 1No.60Beyond the known: prospective research directions for the gut-brain axis in obesity and type 1 diabetes mellitus超越已知：肥胖与1型糖尿病中肠脑轴的未来研究方向DOI: 10.1186/s13098-025-02038-3
BMC women's health IF: 02.700Ahead of Print.No.61PCOS combined with obesity aggravates the metabolic and immune abnormality in females多囊卵巢综合征合并肥胖加重女性代谢与免疫异常DOI: 10.1186/s12905-026-04492-1
International wound journal IF: 02.500Volume 21, Issue 2No.62Evaluation of diabetic foot care knowledge, determinants of self-care practices and the efficacy of health education糖尿病足护理知识、自我护理实践的决定因素及健康教育的有效性评估DOI: 10.1111/iwj.14704
International wound journal IF: 02.500Volume 21, Issue 2No.63RETRACTED: Efficacy of autologous platelet-rich plasma combined with negative pressure sealing drainage in the treatment of patients with diabetic foot ulcer自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡患者的有效性：一项系统评价与荟萃分析DOI: 10.1111/iwj.14700
International wound journal IF: 02.500Volume 21, Issue 2No.64RETRACTED: Effects of continuing nursing intervention on high-risk patients with diabetic foot ulcers: A meta-analysis持续护理干预对高危糖尿病足溃疡患者有效性的荟萃分析DOI: 10.1111/iwj.14683
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.65Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression大黄素通过抑制HIF-1α表达减轻糖尿病肾病大鼠脂质蓄积和肾小管损伤DOI: 10.31083/FBL49862
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.66Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina内源性FGF21缺乏对视网膜炎症微环境的影响DOI: 10.31083/FBL47702
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.67Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale眼部血管参数与基底节和半卵圆中心血管周围间隙扩大的区域关联DOI: 10.31083/JIN49070
J Diabetes Investig IF: 03.000Ahead of Print.No.68Comment on 'Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study'对《慢性冠状动脉综合征患者的血糖控制与肾功能下降：一项多中心队列研究》的评论DOI: 10.1111/jdi.70325
Materials horizons IF: 10.700Ahead of Print.No.69Multi-kingdom biofilms breached: microneedle delivery of metabolically targeted organic silver-photosensitizers for polymicrobial infections in diabetic foot ulcers多界生物膜突破：微针递送代谢靶向有机银光敏剂治疗糖尿病足溃疡中的多种微生物感染DOI: 10.1039/d6mh00459h
J Diabetes Investig IF: 03.000Ahead of Print.No.70Letter to the Editor in response to the article 'Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis'对《亚洲2型糖尿病成人肌少症的患病率与危险因素：系统综述与荟萃分析》一文的致编辑信DOI: 10.1111/jdi.70323
Frontiers in surgery IF: 01.800Volume 13, Issue No.71Risk factors associated with postoperative necrosis after digital replantation: a systematic review and meta-analysis断指再植术后坏死相关危险因素的系统评价与Meta分析DOI: 10.3389/fsurg.2026.1795247
Frontiers in neurology IF: 02.800Volume 17, Issue No.72Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis首次卒中后认知障碍发生率的系统评价与荟萃分析DOI: 10.3389/fneur.2026.1782749
Frontiers in physiology IF: 03.400Volume 17, Issue No.73Efficacy and safety of gabapentinoid combination therapy versus monotherapy for the treatment of neuropathic pain加巴喷丁类药物联合治疗与单药治疗神经病理性疼痛的有效性和安全性比较DOI: 10.3389/fphys.2026.1802999
Frontiers in medicine IF: 03.000Volume 13, Issue No.74Incidence and risk factors of oral mucosal pressure injury in patients with oral tracheal intubation: systematic review and meta-analysis经口气管插管患者口腔黏膜压力性损伤发生率及危险因素的系统评价与Meta分析DOI: 10.3389/fmed.2026.1783726
Frontiers in medicine IF: 03.000Volume 13, Issue No.75Association between serum 25-hydroxyvitamin D, nutritional status, and inflammatory markers in sepsis patients with and without sarcopenia脓毒症合并与不合并肌少症患者血清25-羟基维生素D、营养状态和炎症标志物的关联研究DOI: 10.3389/fmed.2026.1816016
Frontiers in medicine IF: 03.000Volume 13, Issue No.76Construction and validation of a machine learning-based prediction model for postoperative complications in patients with chronic otitis media基于机器学习的慢性中耳炎术后并发症预测模型的构建与验证DOI: 10.3389/fmed.2026.1805224
Frontiers in medicine IF: 03.000Volume 13, Issue No.77Impact of liuwei dihuang pills (decoction) on early diabetic nephropathy: a systematic review and meta-analysis六味地黄丸（汤）对早期糖尿病肾病影响的系统评价与Meta分析DOI: 10.3389/fmed.2026.1802975
Maternal-fetal medicine IF: 01.700Volume 8, Issue 2No.78Global Guidelines on Placenta Accreta Spectrum Disorders: A Commentary From the Chinese Perspective全球胎盘植入性疾病指南：来自中国视角的评论DOI: 10.1097/FM9.0000000000000320
Frontiers in immunology IF: 05.900Volume 17, Issue No.79Influences of dietary intake on Chinese women with gestational diabetes mellitus by inhibiting gut microbiome on plasma metabolome膳食摄入通过抑制肠道微生物组对血浆代谢组的影响在中国妊娠期糖尿病女性中的作用DOI: 10.3389/fimmu.2026.1745459
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.80Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes血糖代谢连续谱（空腹血糖/糖化血红蛋白）与泪膜稳定性和分泌的关联：跨越非糖尿病、糖尿病前期和糖尿病的眼表证据DOI: 10.3389/fendo.2026.1788051
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81Machine learning-based prediction of NAFLD in patients with type 2 diabetes using routine clinical and biochemical indicators基于常规临床和生化指标的机器学习预测2型糖尿病患者非酒精性脂肪性肝病DOI: 10.3389/fendo.2026.1761846
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.82New findings in diabetic kidney disease: correlation and enhanced combined diagnostic value of sclerostin and 25(OH)VD糖尿病肾脏病新发现：硬骨素与25(OH)VD的相关性及联合诊断价值提升DOI: 10.3389/fendo.2026.1817017
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.83The association of serum uric acid with severity and prognosis of patients with diabetic foot ulcers血清尿酸与糖尿病足溃疡患者严重程度及预后的关联DOI: 10.3389/fendo.2026.1732361
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.84Low early-pregnancy serum lipoprotein(a) as an independent associated factor for gestational diabetes mellitus: a retrospective cohort study孕早期血清脂蛋白(a)低水平是妊娠期糖尿病的独立相关因素：一项回顾性队列研究DOI: 10.3389/fendo.2026.1780579
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.85Correction: Multi-feature integrated machine learning prediction model for early nephropathy in elderly living with type 2 diabetes mellitus更正：多特征集成机器学习预测模型用于老年2型糖尿病患者早期肾病DOI: 10.3389/fendo.2026.1807912
Int Med Case Rep J IF: 00.600Volume 19, Issue No.86Ultrasound-Guided Superior Laryngeal Nerve Block Combined with Cricothyroid Membrane Puncture for Awake Tracheal Intubation in a Patient with a Laryngeal Tumor: A Case Report and Literature Review超声引导喉上神经阻滞联合环甲膜穿刺用于喉肿瘤患者清醒气管插管：病例报告与文献综述DOI: 10.2147/IMCRJ.S589800
Frontiers in nutrition IF: 05.100Volume 13, Issue No.87Association between cumulative changes of the C-reactive protein-triglyceride glucose index and the incidence of rapid kidney function decline: a nationwide prospective cohort studyC反应蛋白-甘油三酯葡萄糖指数累积变化与肾功能快速下降发生率的关联：一项全国性前瞻性队列研究DOI: 10.3389/fnut.2026.1795444
Frontiers in nutrition IF: 05.100Volume 13, Issue No.88Structural elucidation and antidiabetic activity of polysaccharides from the parasitic plant Orobanche cumana寄生植物向日葵列当多糖的结构解析与抗糖尿病活性研究DOI: 10.3389/fnut.2026.1785297
Frontiers in nutrition IF: 05.100Volume 13, Issue No.89Microbiota-metabolites interaction associated with glycemic improvement following a dietary herbal intervention in type 2 diabetes2型糖尿病膳食草药干预后与血糖改善相关的微生物群-代谢物相互作用DOI: 10.3389/fnut.2026.1793130
Frontiers in nutrition IF: 05.100Volume 13, Issue No.90New directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy桑叶糖尿病研究新方向：基于多组分协同的转化策略DOI: 10.3389/fnut.2026.1792767
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.91FGFR1/YAP1 signaling in endothelial cells drives renal fibrosis and offers a therapeutic target内皮细胞中FGFR1/YAP1信号驱动肾脏纤维化并提供治疗靶点DOI: 10.3389/fphar.2026.1766265
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.92Paeoniflorin as a candidate disease-modifying therapy for diabetic peripheral neuropathy: mechanisms, exposure challenges, and translational priorities芍药苷作为糖尿病周围神经病变候选疾病修饰疗法：机制、暴露挑战与转化优先事项DOI: 10.3389/fphar.2026.1751578
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.93Development and Validation of a Nursing-Integrated Nomogram to Predict 1-Year Ulcer Recurrence in Patients with Diabetic Foot Ulcers After Endovascular Therapy整合护理评估的列线图预测糖尿病足溃疡患者血管内治疗后1年溃疡复发的开发与验证DOI: 10.2147/DMSO.S591186
The FASEB journal : IF: 04.200Volume 40, Issue 9No.94The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress ResponseE3连接酶RNF8在肝脏应激反应中促进ChREBPα的泛素化和降解DOI: 10.1096/fj.202600106R
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 3No.95Hypoglycaemia Risk Prediction Models for Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病低血糖风险预测模型的系统评价与荟萃分析DOI: 10.1002/edm2.70227
Journal of diabetes IF: 03.700Volume 18, Issue 5No.96Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes胰腺β细胞功能中的线粒体稳态：糖尿病的机制与治疗靶点DOI: 10.1111/1753-0407.70228
Chinese Medical Journal IF: 07.300Ahead of Print.No.97Molecular mechanisms and novel therapeutic targets of diabetic kidney disease糖尿病肾病的分子机制与新型治疗靶点DOI: 10.1097/CM9.0000000000004025
J Int Med Res IF: 01.500Volume 54, Issue 4No.98Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances1型糖尿病新兴疗法：免疫治疗与基因编辑进展DOI: 10.1177/03000605261440833
J Int Med Res IF: 01.500Volume 54, Issue 4No.99Endothelial activation and stress index links to cardiovascular disease in postmenopausal women mediated by arterial stiffness: A cross-sectional study of National Health and Nutrition Examination Survey 1999-2018内皮激活与应激指数与绝经后女性心血管疾病相关：动脉僵硬度的中介作用——基于1999-2018年美国国家健康与营养调查的横断面研究DOI: 10.1177/03000605261434398
J Int Med Res IF: 01.500Volume 54, Issue 4No.100Effects of probiotic supplementation on glycemic control in children with type 1 diabetes: A systematic review and meta-analysis益生菌补充对1型糖尿病儿童血糖控制的影响：系统评价与荟萃分析DOI: 10.1177/03000605261443077
Frontiers in nutrition IF: 05.100Volume 13, Issue No.101Plant-based caloric restriction diets versus conventional calorie-restricted diets for weight loss and metabolic health in obese adults: a 12-week randomized, open-label, non-inferiority trial植物性热量限制饮食与传统热量限制饮食对肥胖成人减重和代谢健康的影响：一项12周随机、开放标签、非劣效性试验DOI: 10.3389/fnut.2026.1805225
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.102Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析DOI: 10.3389/fendo.2026.1764745
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.103Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice二甲双胍和吡格列酮在调节EAE小鼠A1样星形胶质细胞激活中的作用DOI: 10.31083/JIN47364
Frontiers in microbiology IF: 04.500Volume 17, Issue No.104Metformin exacerbates diabetic amyotrophy via oxidative stress and gut microbiota alterations达格列净通过氧化应激和肠道菌群改变加重糖尿病性肌萎缩DOI: 10.3389/fmicb.2026.1778515
Frontiers in immunology IF: 05.900Volume 17, Issue No.105Sheep placental extract ameliorates polycystic ovary syndrome in rats by regulating ERβ-mediated Treg cells via the TGF-β1/Smad3 signaling pathway羊胎盘提取物通过TGF-β1/Smad3信号通路调节ERβ介导的Treg细胞改善大鼠多囊卵巢综合征DOI: 10.3389/fimmu.2026.1777841
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.106Bio-inspired suction cup microneedle loaded fusion membrane targeting nano-drug delivery system treat androgenetic alopecia仿生吸盘微针负载融合膜靶向纳米递药系统治疗雄激素性脱发DOI: 10.1186/s12951-026-04391-5
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.107Quercetin in metabolic diseases: mechanisms, therapeutics, and multidimensional frontiers槲皮素在代谢性疾病中的作用：机制、治疗和多维前沿DOI: 10.3389/fendo.2026.1800322
Frontiers in public health IF: 03.400Volume 14, Issue No.108Dissociation between subjective sleep quality and lipid dysregulation in underground miners: night shift work as an independent risk factor for hypercholesterolemia井下矿工主观睡眠质量与血脂异常的解离：夜班工作是高胆固醇血症的独立危险因素DOI: 10.3389/fpubh.2026.1759787
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.109The DBC1-HIF-1α-PPAR-γ axis regulates Treg cell differentiation to promote myocardial fibrosis in experimental diabetic cardiomyopathy through the paracrine secretion of AregDBC1-HIF-1α-PPAR-γ轴通过旁分泌Areg调节Treg细胞分化促进实验性糖尿病心肌病心肌纤维化DOI: 10.3389/fendo.2026.1780666
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Ultrasound in medicine & biology IF: 02.600Ahead of Print.No.42The feasibility of combining focused ultrasound and copper-cystine biohybrid for diabetic wound healing聚焦超声与铜-胱氨酸生物杂合体联合用于糖尿病伤口愈合的可行性研究DOI: 10.1016/j.ultrasmedbio.2026.03.018
J Int Med Res IF: 01.500Volume 54, Issue 4No.43Association between appendicular lean mass-to-body weight ratio and metabolic syndrome in community-dwelling older adults in Taiwan: A cross-sectional study台湾社区老年人四肢瘦体重与体重比值与代谢综合征的关联：一项横断面研究DOI: 10.1177/03000605261443913
Tohoku J Exp Med IF: 01.600Ahead of Print.No.44Subacute-Onset Hypothyroidism in an Elderly Patient with Polymyalgia Rheumatica: A Case Report老年风湿性多肌痛患者亚急性起病甲状腺功能减退症一例DOI: 10.1620/tjem.2026.J042
J Atheroscler Thromb IF: 02.800Ahead of Print.No.45Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study心血管疾病危险因素与白质病变的关联：东北医疗大型队列研究DOI: 10.5551/jat.65993
Internal medicine IF: 01.100Ahead of Print.No.46A Rare Case of Adult-Onset Human Parechovirus Type A3 Encephalitis成人发病的人副肠孤病毒A3型脑炎罕见病例DOI: 10.2169/internalmedicine.6738-25
Methods in enzymologyVolume 729, Issue No.47Single-molecule fluorescence spectroscopy and imaging of heterogeneous amyloid β aggregation异质性淀粉样β聚集的单分子荧光光谱与成像DOI: 10.1016/bs.mie.2026.01.033
Methods in enzymologyVolume 729, Issue No.48Time-resolved solid-state nuclear magnetic resonance studies of amyloid-β oligomer formation时间分辨固态核磁共振研究淀粉样蛋白-β寡聚体形成DOI: 10.1016/bs.mie.2026.01.035
Methods in enzymologyVolume 729, Issue No.49Opportunities and challenges in the use of pressure-jump NMR to study Aβ and protein oligomerization利用压力跳跃核磁共振研究Aβ和蛋白质寡聚化的机遇与挑战DOI: 10.1016/bs.mie.2026.01.036
BMJ open IF: 02.300Volume 16, Issue 4No.50Understanding the impact, reach and implementation of a health systems intervention to improve diabetes and hypertension care in pluralistic urban public primary care in Bangladesh: a study protocol理解孟加拉国多元城市公共初级保健中改善糖尿病和高血压护理的卫生系统干预的影响、覆盖和实施：一项研究方案DOI: 10.1136/bmjopen-2025-104331
BMJ open IF: 02.300Volume 16, Issue 4No.51Evaluation of an education intervention to support genomics research participation: a community-based pre-post study among participants under-represented in diabetes genomics research支持基因组学研究参与的教育干预评估：一项在糖尿病基因组学研究中代表性不足的参与者中开展的社区前后对照研究DOI: 10.1136/bmjopen-2025-100157
J Dr Nurs Pract IF: 00.200Ahead of Print.No.52Increasing Type 2 Diabetes Screening and Treatment Rates at a Community Clinic在社区诊所提高2型糖尿病筛查和治疗率DOI: 10.1891/JDNP-2024-0063
Canadian family physician IF: 02.400Volume 70, Issue 1No.53Prise en charge du diabète de type 2 chez les patients fragiles脆弱患者2型糖尿病的管理DOI: 10.46747/cfp.7001e10
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.54The effect of baseline prediabetes on the relation between lipoprotein (a) and incident type 2 diabetes mellitus and cardiovascular outcomes: observations from the UK-Biobank基线糖尿病前期状态对脂蛋白(a)与2型糖尿病及心血管结局关系的影响：来自英国生物银行的研究DOI: 10.1016/j.dsx.2026.103422
Kidney international IF: 12.600Ahead of Print.No.55A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney diseaseMEF2C转录因子网络调控糖尿病肾病中肾小球内皮细胞增殖DOI: 10.1016/j.kint.2026.03.020
Environmental pollution IF: 07.300Ahead of Print.No.56Prenatal Exposure to Gas Stoves, Mold, and Water Damage: Associations With Gestational Duration and Fetal Growth in the ECHO Cohort产前暴露于燃气灶、霉菌和水损：与ECHO队列中妊娠时长和胎儿生长的关联DOI: 10.1016/j.envpol.2026.128219
Social science & medicine IF: 05.000Ahead of Print.No.57Using a life table to quantify survival-related selection bias in studies of racial health disparities使用生命表量化种族健康差异研究中的生存相关选择偏倚DOI: 10.1016/j.socscimed.2026.119341
Biosensors & bioelectronics IF: 10.500Ahead of Print.No.58Real-time, label-free impedimetric monitoring of insulin secretion from three-dimensional stem cell-derived islets实时无标记阻抗监测三维干细胞来源胰岛的胰岛素分泌DOI: 10.1016/j.bios.2026.118720
Atención primaria IF: 01.600Ahead of Print.No.59[Effectiveness of telemedicine interventions for the management of gestational diabetes in primary care centers]远程医疗干预在基层医疗中心管理妊娠期糖尿病中的有效性DOI: 10.1016/j.aprim.2026.103504
Diabetes & metabolism IF: 04.700Ahead of Print.No.60Bone phenotype in familial partial lipodystrophy type 2: insulin resistance and sclerostin家族性部分脂肪营养不良2型中的骨表型：胰岛素抵抗与硬骨素DOI: 10.1016/j.diabet.2026.101762
Eye IF: 03.200Ahead of Print.No.61Risk of cerebrovascular and cardiovascular outcomes in patients with an ICD code for ocular migraine眼型偏头痛患者脑血管和心血管结局的风险DOI: 10.1038/s41433-026-04479-0
Scientific reports IF: 03.900Ahead of Print.No.62Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis报销限制降低了安大略省糖尿病成人患者的肝纤维化筛查率：一项基于人群的间断时间序列分析DOI: 10.1038/s41598-026-48600-5
J Diabetes Complications IF: 03.100Ahead of Print.No.63Association between chronic low-grade inflammation and metabolic syndrome and their impact on the risk of coronary artery disease in type 1 diabetes1型糖尿病中慢性低度炎症与代谢综合征的关联及其对冠状动脉疾病风险的影响DOI: 10.1016/j.jdiacomp.2026.109331
BMJ open IF: 02.300Volume 16, Issue 4No.64Prevent 6:1 trial: pI rotocol for a feasibility trial of a 6:1 intermittent diet for weight gain prevention in women at increased risk of breast cancerPrevent 6:1试验：6:1间歇性饮食预防乳腺癌高风险女性体重增加的可行性试验方案DOI: 10.1136/bmjopen-2025-113204
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.65Neuroprotective strategies for cognitive decline in type 2 diabetes2型糖尿病认知衰退的神经保护策略DOI: 10.1016/j.tem.2026.04.003
Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2026, Issue 2No.66Pheochromocytoma and primary hyperparathyroidism: a very rare association in a neurofibromatosis type 1 patient unmasked by Takotsubo syndrome嗜铬细胞瘤与原发性甲状旁腺功能亢进症：Takotsubo综合征揭示的1型神经纤维瘤病患者中极为罕见的关联DOI: 10.1530/EDM-25-0109
Internal medicine IF: 01.100Ahead of Print.No.67Impact of Tirzepatide on FIB-4 in Patients with Type 2 Diabetes: A Comparison between GLP-1RA-naïve and GLP-1RA Switch Initiation in a Retrospective Cohort替尔泊肽对2型糖尿病患者FIB-4的影响：GLP-1RA初治与转换治疗的回顾性队列比较DOI: 10.2169/internalmedicine.6886-25
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.68Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)普瑞巴林与α-硫辛酸联合治疗痛性糖尿病周围神经病变患者的有效性和安全性：一项随机、开放标签、非劣效性、IV期临床试验及亚组分析（OPTIMUM研究）DOI: 10.1111/dom.70795
Domestic animal endocrinology IF: 02.100Ahead of Print.No.69Ertugliflozin decreases the insulin spike in non-insulin dysregulated standardbred horses following intra-articular triamcinolone administration艾托格列净降低非胰岛素调节异常的标准马关节内注射曲安奈德后的胰岛素峰值DOI: 10.1016/j.domaniend.2026.107016
Annals of family medicine IF: 05.100Ahead of Print.No.70Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation专科评估前肌痛性脑脊髓炎/慢性疲劳综合征药物治疗使用不足DOI: 10.1370/afm.250266
Nature IF: 48.500Ahead of Print.No.71A cell atlas charts the immune architecture of diabetic kidney disease细胞图谱揭示糖尿病肾病的免疫结构DOI: 10.1038/d41586-026-01177-5
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.72Cardiovascular–kidney–metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management心血管-肾脏-代谢综合征：病理生理学、流行病学、诊断和管理的全面综述DOI: 10.1186/s12933-026-03177-1
JMIR serious games IF: 04.100Volume 14, Issue No.73User Experience of a Virtual Reality-Based Treadmill for Children With a Chronic Disease Affecting Physical Health: Cross-Sectional Feasibility Study基于虚拟现实的跑步机对患有影响身体健康的慢性疾病儿童的用户体验：横断面可行性研究DOI: 10.2196/82953
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.74U.S. Adolescents of Asian Ethnicity have Higher Risk of Polycystic Ovary Syndrome美国亚裔青少年患多囊卵巢综合征风险更高DOI: 10.1159/000552156
Journal of obesity IF: 03.900Volume 2026, Issue 1No.75Prevalence and Factors Associated With Severe Obesity Among U.S. Adults: A Cross-Sectional Study美国成年人重度肥胖的患病率及相关因素：一项横断面研究DOI: 10.1155/jobe/3831008
JMIR human factors IF: 03.000Volume 13, Issue No.76Continuous Glucose Monitoring for Personalized Nutrition in Real-World Vively App Users: Retrospective Observational Study真实世界Vively应用用户中持续葡萄糖监测用于个性化营养的回顾性观察研究DOI: 10.2196/80734
JMIR human factors IF: 03.000Volume 13, Issue No.77Evaluation of Combined Educational Methods on Motivational Interviewing for Final-Year Medical Students: Mixed Methods Study联合教育方法对医学生动机性访谈能力的影响：混合方法研究DOI: 10.2196/89126
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.78Incidence and Associated Factors of ST-Segment Changes in Noncardiac Surgery Under General Anesthesia全身麻醉下非心脏手术ST段改变的发生率及关联因素DOI: 10.4103/aca.aca_243_25
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.79[Transitional cognitive syndrome: Reconsidered classification of cognitive disorders]过渡性认知综合征：认知障碍分类的再思考DOI: 10.17116/jnevro202612604247
PloS one IF: 02.600Volume 21, Issue 4No.80Catastrophic health care expenditure among older people with non-communicable diseases in 11 European Union Member States11个欧盟成员国患有非传染性疾病的老年人灾难性医疗支出研究DOI: 10.1371/journal.pone.0346341
Einstein IF: 01.100Volume 24, Issue No.81Factors associated with sleep quality and duration in mothers of children with autism spectrum disorder: a cross-sectional study自闭症谱系障碍儿童母亲睡眠质量与时长相关因素：一项横断面研究DOI: 10.31744/einstein_journal/2026AO2004
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.82SGLT2 Inhibitors versus GLP-1 Receptor Agonists Type 2 Diabetes, The Kidney ConundrumSGLT2抑制剂与GLP-1受体激动剂在2型糖尿病中的比较：肾脏难题DOI: 10.2215/CJN.0000001068
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.83[Current evidence-based approaches to the treatment of vascular cognitive impairment]当前血管性认知障碍治疗的循证方法DOI: 10.17116/jnevro202612604278
PloS one IF: 02.600Volume 21, Issue 4No.84Spatial and temporal modeling of breast cancer mortality in Kansas: An R-INLA approach堪萨斯州乳腺癌死亡率时空建模：基于R-INLA方法DOI: 10.1371/journal.pone.0347607
PloS one IF: 02.600Volume 21, Issue 4No.85Implications of acute change in estimated Glomerular Filtration Rate (eGFR) for the effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on long-term endpoints估算肾小球滤过率急性变化对钠-葡萄糖协同转运蛋白2抑制剂长期终点效应的影响DOI: 10.1371/journal.pone.0347741
AIDS IF: 03.100Volume 40, Issue 6No.86SGLT2 inhibitor dapagliflozin attenuates HIV-associated cardiac fibrosis, steatosis and diastolic dysfunction in a mouse model via inhibition of TGFβ signalingSGLT2抑制剂达格列净通过抑制TGFβ信号减轻HIV相关的心脏纤维化、脂肪变性和舒张功能障碍（小鼠模型）DOI: 10.1097/QAD.0000000000004464
The Lancet HIV IF: 13.000Volume 13, Issue 5, Page e287-e356No.87Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trialHIV感染者高血压的发病率、危险因素及心血管影响：REPRIEVE试验的二次分析DOI: 10.1016/S2352-3018(26)00036-6
PloS one IF: 02.600Volume 21, Issue 4No.88Criterion validity and divergent risk profiles of long-term opioid therapy across medicare and medicaid长期阿片类药物治疗在Medicare和Medicaid中的标准效度及风险特征差异DOI: 10.1371/journal.pone.0347943
JMIR research protocols IF: 01.500Volume 15, Issue No.89The Current Landscape of Remote Patient Monitoring Regarding Diabetes Mellitus and Hypoglycemia: Protocol for a Scoping Review远程患者监测在糖尿病和低血糖管理中的现状：范围综述方案DOI: 10.2196/88197
Science advances IF: 12.500Volume 12, Issue 18No.90IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumorsIRS4是一种通过DNA重排或表观遗传机制在多种实体瘤中上调的PI3K激活型癌症依赖性基因DOI: 10.1126/sciadv.aeb3503
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.91Incidence and Predictors of Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review心脏手术后新发房颤的发生率及预测因素：一项系统综述DOI: 10.4103/aca.aca_285_25
Heart Rhythm IF: 05.700Ahead of Print.No.92Identification of Clinical Risk Factors for Arrhythmia Recurrence in Atrial Fibrillation Patients Undergoing Catheter Ablation: A Systematic review and Meta-analysis房颤导管消融术后心律失常复发的临床危险因素识别：系统评价与荟萃分析DOI: 10.1016/j.hrthm.2026.04.046
Heart IF: 04.400Ahead of Print.No.93Derivation and validation of a prediction model for long-term mortality in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: the PREDICT-ST-Elevation Myocardial Infarction scoreST段抬高型心肌梗死患者经皮冠状动脉介入治疗后长期死亡率预测模型的推导与验证：PREDICT-STEMI评分DOI: 10.1136/heartjnl-2026-327811
Indian Journal of Ophthalmology IF: 01.800Volume 74, Issue 5No.94Biosimilar anti-vascular endothelial growth factor agents: Clinical outcomes, safety, and cost-effectiveness in India生物类似药抗血管内皮生长因子制剂在印度的临床结局、安全性和成本有效性DOI: 10.4103/IJO.IJO_3222_25
JAMA dermatology IF: 11.000Ahead of Print.No.95Deuterated Pentoxifylline Analog in the Treatment of Necrobiosis Lipoidica: A Nonrandomized Clinical Trial氘代己酮可可碱类似物治疗类脂质渐进性坏死：一项非随机临床试验DOI: 10.1001/jamadermatol.2026.0863
Lasers in medical science IF: 02.400Volume 41, Issue 1No.96Photobiomodulation combined with dynamic thermal imaging as a diagnostic tool for chronic leg ulcers光生物调节联合动态热成像作为慢性腿部溃疡的诊断工具DOI: 10.1007/s10103-026-04878-5
Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.97Myeloid transglutaminase 2 regulates Treg-Th17 balance in a female model of Angiotensin II-induced hypertension and vascular stiffening髓系转谷氨酰胺酶2在血管紧张素II诱导的高血压和血管硬化雌性模型中调节Treg-Th17平衡DOI: 10.1152/ajpheart.00095.2026
Journal of fluorescence IF: 03.100Ahead of Print.No.98Design and Optimization of a Glucose Fluorescence Nano-biosensor Based on Graft Copolymer of Poly(acrylic acid)-co-(vinyl phenyl boronic acid)-g-gelatin to Modify CdTe/TGA QDs基于聚丙烯酸-co-乙烯基苯硼酸-g-明胶接枝共聚物修饰CdTe/TGA量子点的葡萄糖荧光纳米生物传感器的设计与优化DOI: 10.1007/s10895-026-04763-y
International ophtalmology IF: 01.400Volume 46, Issue 1No.99Clinical and demographic characteristics of glaucoma patients in Kingston, Jamaica牙买加金斯敦青光眼患者的临床和人口学特征DOI: 10.1007/s10792-026-04020-y
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.100Psychosocial adaptation of parents of children with type 1 diabetes: a cross-sectional study1型糖尿病患儿父母的心理社会适应：一项横断面研究DOI: 10.1515/jpem-2026-0061
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.101Age and sexual maturation at Spermarche in boys with Laron syndromeLaron综合征男孩首次遗精的年龄与性成熟DOI: 10.1515/jpem-2026-0043
Advances in physiology education IF: 01.700Ahead of Print.No.102The Development and Impact of an Innovative Graduate Program To Promote Entry to Physiology-Related Careers: The Master of Health Science in Medical Physiology创新研究生项目促进生理学相关职业发展的开发与影响：医学生理学健康科学硕士DOI: 10.1152/advan.00060.2026
Diabetes care IF: 16.600Ahead of Print.No.103Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!错误的笔触持续瓦解和摧毁美国生物医学研究：我们不能再容忍自满与恐惧，必须立即行动！DOI: 10.2337/dci26-0068
Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.104Serum Proenkephalin A as a Marker of Renal Dysfunction and Glycemic Status in Diabetic Nephropathy血清前脑啡肽A作为糖尿病肾病肾功能不全和血糖状态的标志物DOI: 10.1177/15578518261444701
Pancreas IF: 01.700Ahead of Print.No.105Predictive Power of Imaging: Assessing Parenchymal Fibrosis in Pediatric Chronic Pancreatitis影像学预测能力：评估儿童慢性胰腺炎实质纤维化DOI: 10.1097/MPA.0000000000002658
Pol Arch Intern Med IF: 04.700Volume 136, Issue 4No.106Corrections: Assessment of the type 2 diabetes risk using the Finnish Diabetes Risk Score questionnaire, and its predictors at the population level in Poland更正：使用芬兰糖尿病风险评分问卷评估2型糖尿病风险及其在波兰人群水平上的预测因素DOI: 10.20452/pamw.17283
Medical care research and review IF: 02.200Ahead of Print.No.107Defining the Social Needs Service Cascade: Evidence From A Multistakeholder Qualitative Study定义社会需求服务级联：来自多利益相关者定性研究的证据DOI: 10.1177/10775587261439173
Global spine journal IF: 03.000Ahead of Print.No.108Incidence and Risk Factors for 30- and 90-day Reoperations Following Biportal Endoscopic Lumbar Discectomy for Single-Level Lumbar Disc Herniations单节段腰椎间盘突出症双通道内镜下椎间盘切除术后30天和90天再手术的发生率及危险因素DOI: 10.1177/21925682261448186
Plast Reconstr Surg IF: 03.400Ahead of Print.No.109Massive Weight Loss with Bariatric Surgery and GLP-1RA Therapy Predicts Postoperative Complications Following Abdominal Body Contouring减重手术与GLP-1RA治疗导致的巨大体重下降预示腹部塑形术后并发症DOI: 10.1097/PRS.0000000000013015
Inflammopharmacology IF: 05.300Ahead of Print.No.110Dapagliflozin mitigates acute pancreatitis induced by L-arginine in Rats through modulation of TLR-4/NF-κB/NLRP3 pathway: integrated biochemical, histopathological, and in silico study达格列净通过调节TLR-4/NF-κB/NLRP3通路减轻L-精氨酸诱导的大鼠急性胰腺炎：整合生化、组织病理学和计算机模拟研究DOI: 10.1007/s10787-026-02190-w
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.111Dapagliflozin ameliorates high-fat diet-induced, megalin-mediated autolysosomal dysfunction in proximal tubules via suppression of megalin-dependent endocytosis达格列净通过抑制megalin依赖性内吞改善高脂饮食诱导的近端肾小管megalin介导的自噬溶酶体功能障碍DOI: 10.1152/ajprenal.00448.2025
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.112Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density年轻成人炎症性关节炎患者的骨骼健康：低骨密度相关因素的评估DOI: 10.1007/s11657-026-01710-z
JAMA psychiatry IF: 17.100Ahead of Print.No.113Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial司美格鲁肽与重度抑郁症中基于努力的决策：一项随机临床试验DOI: 10.1001/jamapsychiatry.2026.0594
Irish journal of medical science IF: 01.600Ahead of Print.No.114Associations of Mediterranean, DASH, and MIND diet adherence with metabolic parameters in individuals with type 2 diabetes mellitus: a cross-sectional study地中海饮食、DASH饮食和MIND饮食依从性与2型糖尿病患者代谢参数的相关性：一项横断面研究DOI: 10.1007/s11845-026-04415-x
J Egypt Public Health Assoc IF: 02.500Volume 101, Issue 1No.115Psychometric evaluation of the Arabic brief forms of the diabetes distress scale in Egyptian patients with type II diabetes阿拉伯语简短版糖尿病痛苦量表在埃及2型糖尿病患者中的心理测量学评估DOI: 10.1186/s42506-026-00216-3
Retinal cases & brief reportsAhead of Print.No.116Atypical (Three-Quadrant) Central Retinal Vein Occlusion: A Report of two cases and review of literature非典型（三象限）视网膜中央静脉阻塞：两例报告及文献综述DOI: 10.1097/ICB.0000000000001929
Nursing research IF: 02.200Ahead of Print.No.117Perceived Family Support and Treatment Adherence in Older Adults With Type 2 Diabetes老年2型糖尿病患者感知到的家庭支持与治疗依从性DOI: 10.1097/NNR.0000000000000914
Wound repair and regeneration IF: 03.400Volume 34, Issue 3No.118A First-In-Human Study of Pyroligneous Extract, the Biomaterial Derived From Pyrolytic Palm Kernel Shell Wood Vinegar as a Novel Wound Healing Aid on Diabetic Foot Ulcer热解棕榈仁壳木醋液衍生的生物材料——焦木提取物作为糖尿病足溃疡新型伤口愈合辅助剂的首次人体研究DOI: 10.1111/wrr.70166
Multiple sclerosis : IF: 05.000Ahead of Print.No.119Use of semaglutide and tirzepatide among people with multiple sclerosis司美格鲁肽和替尔泊肽在多发性硬化患者中的使用情况DOI: 10.1177/13524585261442033
Food science of animal resources IF: 03.700Volume 44, Issue 1No.120Oral Administration of Lactilactobacillus curvatus LB-P9 Promotes Hair Regeneration in Mice口服弯曲乳杆菌LB-P9促进小鼠毛发再生DOI: 10.5851/kosfa.2023.e74
Clinical transplantation IF: 01.900Volume 40, Issue 5No.121Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation全胰腺切除联合胰岛自体移植后胰岛素独立患者低血糖的发生率及危险因素DOI: 10.1111/ctr.70549
Physiology IF: 10.300Ahead of Print.No.122Multicellular Crosstalk and Therapeutic Vaccines in Heart Failure心力衰竭中的多细胞串扰与治疗性疫苗DOI: 10.1152/physiol.00007.2026
JAMA Network Open IF: 09.700Volume 9, Issue 4No.123Hypertrophic Cardiomyopathy and Risk of Out-of-Hospital Cardiac Arrest肥厚型心肌病与院外心脏骤停风险DOI: 10.1001/jamanetworkopen.2026.9673
Am J Physiol Regul Integr Comp Physiol IF: 02.300Ahead of Print.No.124B-Raf is required for normal murine cardiac development and functionB-Raf对小鼠正常心脏发育和功能是必需的DOI: 10.1152/ajpregu.00063.2025
The Prostate IF: 02.500Ahead of Print.No.125Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications前列腺癌、遗传易感性与慢性非泌尿系统并发症风险DOI: 10.1002/pros.70190
J Eval Clin Pract IF: 02.100Volume 32, Issue 4No.126A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community-Based Diabetic Population: Study Design of the TAMIS Trial远程慢性病管理项目改善多样化社区糖尿病人群心血管和代谢结局：TAMIS试验研究设计DOI: 10.1111/jep.70456
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.127Distinct Antibody Signatures to Human Endogenous Retroviruses and Mycobacterium Paratuberculosis in Newly Diagnosed Tunisian Type 1 Diabetes Patients新诊断突尼斯1型糖尿病患者中人内源性逆转录病毒和副结核分枝杆菌的独特抗体特征DOI: 10.1007/s12013-026-02068-2
Journal of Human Hypertension IF: 03.400Ahead of Print.No.128Consensus on the management of hypertension in individuals with diabetes by Asian-Pacific Society of hypertension (APSH) & Diabetes Asia Study Group (DASG).亚太高血压学会与糖尿病亚洲研究组关于糖尿病患者高血压管理的共识DOI: 10.1038/s41371-026-01150-9
JAMA Cardiology IF: 14.100Ahead of Print.No.129Timeliness of Transthyretin Cardiac Amyloidosis Diagnosis in the Medicare Population医疗保险人群中转甲状腺素蛋白心脏淀粉样变性诊断的及时性DOI: 10.1001/jamacardio.2026.0833
JACC IF: 22.300Ahead of Print.No.130Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions美国医疗系统中8种心血管疾病临床多基因风险报告的开发与验证DOI: 10.1016/j.jacc.2026.03.035
Mol Cell Biochem IF: 03.700Ahead of Print.No.131Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus胎盘炎症升高作为妊娠期糖尿病不良结局的介导因素DOI: 10.1007/s11010-026-05561-7
Irish journal of medical science IF: 01.600Ahead of Print.No.132Reduced fetal MAPSE and TAPSE in gestational diabetes mellitus: a prospective case-control study妊娠期糖尿病胎儿二尖瓣环收缩期位移与三尖瓣环收缩期位移降低：一项前瞻性病例对照研究DOI: 10.1007/s11845-026-04426-8
Soc Psychiatry Psychiatr Epidemiol IF: 03.500Ahead of Print.No.133Association between maternal pregnancy complications and long-term depressive and anxiety disorders: evidence from the UK millennium cohort study母体妊娠并发症与长期抑郁和焦虑障碍的关联：来自英国千禧队列研究的证据DOI: 10.1007/s00127-026-03094-4
JAHA IF: 05.300Ahead of Print.No.134Acute Impact of Transcatheter Edge-to-Edge Repair of Tricuspid Regurgitation on Right Ventricular Hemodynamics经导管缘对缘修复三尖瓣反流对右心室血流动力学的急性影响DOI: 10.1161/JAHA.125.047560
Endokrynologia Polska IF: 02.100Volume 77, Issue 2No.135Eradicating hyperandrogenism? Hormonal changes following Helicobacter pylori eradication in women with polycystic ovary syndrome: an observational case series根除幽门螺杆菌后多囊卵巢综合征女性的激素变化：一项观察性病例系列研究DOI: 10.5603/ep.110428
Saudi pharmaceutical journal IF: 03.400Volume 34, Issue 2No.136Efficacy and safety of pharmacological and procedural interventions in the management of hypertriglyceridemia-induced acute pancreatitis: a systematic review药物和介入干预治疗高甘油三酯血症诱导的急性胰腺炎的有效性和安全性：一项系统评价DOI: 10.1007/s44446-026-00078-y
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.137Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4-Year Follow-Up Cohort StudyCPAP治疗对阻塞性睡眠呼吸暂停合并脂肪性肝病患者肝脏脂肪变性和胰岛素抵抗的有效性：一项4年随访队列研究DOI: 10.1002/kjm2.70222
JAHA IF: 05.300Ahead of Print.No.138Glucose-6-Phosphate Dehydrogenase Modifies the Impact of Glucose on Arterial Aging in A Sex-Specific Manner葡萄糖-6-磷酸脱氢酶以性别特异性方式调节葡萄糖对动脉老化的影响DOI: 10.1161/JAHA.125.045538
JAMA IF: 55.000Ahead of Print.No.139Pigmentary Changes That Developed During Pregnancy妊娠期色素沉着变化DOI: 10.1001/jama.2026.2928
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.140Hypothalamic regulation of energy homeostasis: Quo vadis下丘脑对能量稳态的调控：何去何从DOI: 10.1007/s11154-026-10042-9
Obesity surgery IF: 03.100Ahead of Print.No.141Food Consumption by Processing Levels in Adults Two or More Years After Sleeve Gastrectomy: Associations with Surgical Outcomes and Eating Behaviors袖状胃切除术后两年及以上成年人按加工级别分类的食物消费：与手术结局和饮食行为的关联DOI: 10.1007/s11695-026-08582-9
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.142Effects of Diet-Induced Obesity and Exercise Intervention on Testicular Germ Cell Health: Modulation of SIRT1/FoxO1 and SIRT1/PGC-1α Signaling Axes饮食诱导肥胖与运动干预对睾丸生殖细胞健康的影响：SIRT1/FoxO1和SIRT1/PGC-1α信号轴的调节DOI: 10.1007/s12013-026-02076-2
BJS open IF: 04.500Volume 10, Issue 2No.143Sleeve gastrectomy versus Roux-en-Y-gastric bypass in patients with body mass index over 50 kg/m2: international multicentre cohort袖状胃切除术与Roux-en-Y胃旁路术在体重指数超过50 kg/m²患者中的比较：国际多中心队列研究DOI: 10.1093/bjsopen/zrag028
J Clin Pharmacol IF: 02.300Volume 66, Issue 5No.144Assessment of the Drug-Drug Interaction Potential of Lotiglipron (PF-07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol评估Lotiglipron（PF-07081532）与咪达唑仑、奥美拉唑、达比加群、瑞舒伐他汀以及口服避孕药左炔诺孕酮和炔雌醇的药物相互作用潜力DOI: 10.1002/jcph.70158
Health informatics journal IF: 02.300Volume 32, Issue 2No.145An informatics-based data-led prioritization strategy to facilitate objective and equitable care for an ethnically diverse urban cohort of people with type 1 diabetes: A proof-of-concept study基于信息学的数据主导优先排序策略：为种族多样化的城市1型糖尿病患者群体提供客观公平护理的概念验证研究DOI: 10.1177/14604582261436276
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.146A scoring system for validity assessment of biomarkers of food intake食物摄入生物标志物有效性评估评分系统DOI: 10.1080/10408398.2026.2633561
Nutrition and health IF: 01.400Ahead of Print.No.147Influence of autonomic function on the thermic effect of food and postprandial insulin sensitivity in individuals with obesity, submitted to a test meal with or without ultra-processed foods: Secondary analysis of a randomized trial自主神经功能对肥胖个体食物热效应和餐后胰岛素敏感性的影响：一项随机试验的二次分析DOI: 10.1177/02601060261446525
Nutrition reviews IF: 04.900Ahead of Print.No.148Methyl Donor Nutrient Intake as a Modulator of the Association between FTO Gene Variants and BMI: A Systematic Review with Meta-Analysis and Meta-Regression甲基供体营养素摄入作为FTO基因变异与体重指数之间关联的调节因素：系统综述、荟萃分析和荟萃回归DOI: 10.1093/nutrit/nuag035
Journal of human lactation : IF: 01.800Ahead of Print.No.149Linking Early Infant Growth With Milk-Derived Antibodies, Hormones, and Macronutrients During Exclusive Breastfeeding纯母乳喂养期间早期婴儿生长与母乳中抗体、激素和宏量营养素的关联DOI: 10.1177/08903344261430138
Open Heart IF: 02.800Volume 13, Issue 1No.150Are clinical improvements in anxiety or depression associated with improvement in walking fitness following a cardiac rehabilitation programme?心脏康复计划后焦虑或抑郁的临床改善是否与步行能力的改善相关？DOI: 10.1136/openhrt-2026-004051
Thyroid research IF: 01.800Volume 19, Issue 1No.151Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE(®) 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study在未经筛选的临床人群中，使用IMMULITE® 2000 TSI检测法测量促甲状腺激素受体抗体优于BRAHMS TRAK检测法，但两者表现均低于预期：一项真实世界回顾性观察研究DOI: 10.1186/s13044-026-00296-5
Int J Reprod Biomed IF: 01.800Volume 24, Issue 2No.152Therapeutic effects of Foeniculum vulgare and Achillea millefolium on ovarian function in a mouse model of polycystic ovary syndrome: An experimental study茴香和蓍草对多囊卵巢综合征小鼠模型卵巢功能的治疗作用：一项实验研究DOI: 10.18502/ijrm.v24i2.21053
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.153Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review多囊卵巢综合征胰岛素抵抗与碳水化合物代谢改变的分子机制：一项范围综述DOI: 10.3389/fendo.2026.1810805
bioRxivVolume 2026, Issue No.154Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO (2) Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans不同生命阶段中进食状态依赖的CO2趋化可塑性的不同分子机制DOI: 10.64898/2026.02.06.704338
BMC research notes IF: 01.700Ahead of Print.No.155In vitro assessment of the impact of di(2-ethylhexyl) phthalate and its metabolites on the function and transcription of key glucose sensing proteins in a rat pancreatic β-cell line邻苯二甲酸二(2-乙基己基)酯及其代谢物对大鼠胰腺β细胞系关键葡萄糖感应蛋白功能和转录影响的体外评估DOI: 10.1186/s13104-026-07830-6
JACC: AdvancesVolume 5, Issue 5No.156Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock心源性休克患者糖尿病亚型的特征、管理及主要终点DOI: 10.1016/j.jacadv.2026.102766
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.157Prognostic value of advanced imaging biomarkers for the progression of diabetic retinopathy: a systematic review先进影像生物标志物对糖尿病视网膜病变进展的预后价值：一项系统评价DOI: 10.1186/s13098-026-02159-3
Current obesity reports IF: 11.000Volume 15, Issue 1No.158The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights非洲全球共病流行病学：新证据与关键见解DOI: 10.1007/s13679-026-00717-4
Frontiers in health services IF: 02.700Volume 6, Issue No.159Therapeutic intensity and patient-reported outcomes among heart failure patients in a pharmacist-led medication therapy adherence clinic program in Malaysia马来西亚药师主导的药物治疗依从性门诊项目中心力衰竭患者的治疗强度与患者报告结局DOI: 10.3389/frhs.2026.1784432
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.160Acromegalic features and hypoglycemia: Doege-Potter syndrome肢端肥大症特征与低血糖：Doege-Potter综合征DOI: 10.22088/cjim.17.1.205
JCEM case reportsVolume 4, Issue 5No.161A rare case of dual hormone-secreting pulmonary neuroendocrine tumor causing concurrent Cushing syndrome and acromegaly一例罕见的双重激素分泌性肺神经内分泌肿瘤导致库欣综合征和肢端肥大症并存DOI: 10.1210/jcemcr/luag092
Journal of Hypertension IF: 04.100Volume 44, Issue 6No.162Response to letter 'Sex-specific associations between TyG index and emotional states'对《TyG指数与情绪状态的性别特异性关联》一信的回复DOI: 10.1097/HJH.0000000000004289
Int J Eat Disord IF: 04.300Ahead of Print.No.163Sex Differences in Social, Health, and Lifestyle Characteristics Associated With Binge-Eating Behaviors: Results From a French National Random Population-Based Study与暴食行为相关的社会、健康和生活方式特征的性别差异：基于法国全国随机人群研究的结果DOI: 10.1002/eat.70113
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.164Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling脂质比值生物标志物作为新诊断代谢综合征患者抑郁症状的保护因素：来自回归模型的证据DOI: 10.31083/JIN49628
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.165The association between appendicular skeletal muscle index and liver steatosis and fibrosis: A cross-sectional study四肢骨骼肌指数与肝脏脂肪变性和纤维化的关联：一项横断面研究DOI: 10.22088/cjim.17.1.113
Front Sports Act Living IF: 02.600Volume 8, Issue No.166Physiological and cortical determinants of exercise tolerance in sedentary women with obesity久坐肥胖女性运动耐量的生理和皮层决定因素DOI: 10.3389/fspor.2026.1771921
Int J Womens Health IF: 02.600Volume 18, Issue No.167Comparison of Surgical Outcomes Among Open, Laparoscopic, and Robotic Surgeries in Women with Obesity Diagnosed with Endometrial Cancer: Results from a Quaternary Hospital in Thailand肥胖子宫内膜癌患者开腹、腹腔镜与机器人手术结局比较：泰国一家四级医院的结果DOI: 10.2147/IJWH.S598487
JBMR plus IF: 02.400Volume 10, Issue 5No.168Pain medication use in patients with X-linked hypophosphatemia treated with burosumab: a retrospective real-world study布罗索尤单抗治疗X连锁低磷血症患者的止痛药使用：一项回顾性真实世界研究DOI: 10.1093/jbmrpl/ziag047
Journal of affective disorders reportsVolume 24, Issue No.169Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery深度学习模型对减重代谢手术后新发焦虑的洞察DOI: 10.1016/j.jadr.2026.101061
Frontiers in psychology IF: 02.900Volume 17, Issue No.170Didactic adaptation of basketball in physical education to reduce anxiety and emotional eating in adolescent girls with obesity: a randomized controlled trial体育教育中篮球教学适应性改编对肥胖青少年女性焦虑和情绪性进食的影响：一项随机对照试验DOI: 10.3389/fpsyg.2026.1753266
Front Behav Neurosci IF: 02.900Volume 20, Issue No.171Revisiting food addiction in the era of GLP-1-based obesity pharmacotherapy via neural reward pathways linking feeding and substance use在基于GLP-1的肥胖药物治疗时代重新审视食物成瘾：通过连接进食与物质使用的神经奖赏通路DOI: 10.3389/fnbeh.2026.1805953
J Diabetes Investig IF: 03.000Ahead of Print.No.172Validation of the ST1RE risk engine in Chinese with type 1 diabetes and comparison with the JADE, RECODe, and UKPDS risk scoresST1RE风险引擎在中国1型糖尿病患者中的验证及与JADE、RECODe和UKPDS风险评分的比较DOI: 10.1111/jdi.70316
British journal of nutrition IF: 03.000Ahead of Print.No.173Patterns of dietary habits are associated with metabolic health status in adults膳食习惯模式与成人代谢健康状态相关DOI: 10.1017/S0007114526106722
Mol Nutr Food Res IF: 04.200Volume 70, Issue 9No.174Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study母亲时间营养与胎盘DNA甲基化：BiSC研究DOI: 10.1002/mnfr.70465
Lipids IF: 01.600Ahead of Print.No.175Hepatic Lipids as Molecular Targets in Obesity-Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta-Analysis啮齿动物模型中肝脏脂质作为肥胖相关胰岛素抵抗的分子靶点：系统综述与荟萃分析DOI: 10.1002/lipd.70061
J Diabetes Investig IF: 03.000Ahead of Print.No.176Time in range during caloric restriction in type 2 diabetes with obesity肥胖2型糖尿病患者热量限制期间的血糖在目标范围内时间DOI: 10.1111/jdi.70308
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.177Indirect Comparative Efficacy and Safety of Tirzepatide Versus Oral Semaglutide for the Treatment of Overweight and Obesity替尔泊肽与口服司美格鲁肽治疗超重和肥胖的间接比较有效性和安全性DOI: 10.1111/dom.70773
British journal of nutrition IF: 03.000Ahead of Print.No.178Contribution of meals to energy and nutrient intakes and implication of skipping meals on nutritional status among primary schoolchildren in Malaysia马来西亚小学生膳食对能量和营养素摄入的贡献及不吃饭对营养状况的影响DOI: 10.1017/S0007114526107314
J Health Popul Nutr IF: 02.800Ahead of Print.No.179Malnutrition among men in Ghana: socio-demographic factors and rural-urban differences加纳男性营养不良：社会人口因素与城乡差异DOI: 10.1186/s41043-026-01325-7
Allergy IF: 12.000Ahead of Print.No.180Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome食物蛋白诱导性小肠结肠炎综合征患儿肠道和唾液微生物群的纵向随访DOI: 10.1111/all.70363
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.181Potential Application of HIF-PH Inhibitors to Treat Kidney DiseasesHIF-PH抑制剂治疗肾脏疾病的潜在应用DOI: 10.31083/FBL47718
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.182The Gut-Lung Axis, Epigenetics and Respiratory Disease肠-肺轴、表观遗传学与呼吸系统疾病DOI: 10.31083/FBL48743
Revista de neurología IF: 00.800Volume 81, Issue 4No.183Peripheral Neuropathy: A Phenotype-Driven Review for Diagnosis and Management周围神经病变：基于表型的诊断与管理综述DOI: 10.31083/RN48384
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.184Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran吡非尼酮对重症COVID-19患者肺部CT扫描影响的研究DOI: 10.22088/cjim.17.1.163
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.185Detecting coronary artery disease among the individuals with left-sided dominant coronary circulation左侧优势型冠状动脉循环个体中冠状动脉疾病的检测DOI: 10.22088/cjim.17.1.173
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.186Association of interleukin-8 and neutrophil-to-lymphocyte ratio with clinical indices in diabetic nephropathy白细胞介素-8和中性粒细胞与淋巴细胞比值与糖尿病肾病临床指标的相关性DOI: 10.22088/cjim.17.1.191
Sleep AdvVolume 7, Issue 2No.187Using consumer sleep trackers for sleep extension interventions: retention, adherence, and user experiences使用消费者睡眠追踪器进行睡眠延长干预：保留率、依从性和用户体验DOI: 10.1093/sleepadvances/zpag025
Health science reports IF: 02.100Volume 9, Issue 5No.188How Pre-Pregnancy Weight and Polycystic Ovary Syndrome Impact Pregnancy Outcomes: A Population-Based Cohort Study孕前体重与多囊卵巢综合征对妊娠结局的影响：一项基于人群的队列研究DOI: 10.1002/hsr2.72088
Frontiers in ophthalmologyVolume 6, Issue No.189Use of preoperative swept-source optical coherence tomography in vitrectomy for advanced diabetic eye disease: a pilot study术前扫频源光学相干断层扫描在晚期糖尿病眼病玻璃体切除术中的应用：一项初步研究DOI: 10.3389/fopht.2026.1688660
Clin Med Insights Endocrinol Diabetes IF: 03.000Volume 19, Issue No.190Euthyroid Sick Syndrome Precipitated By Rapid Weight Loss Following Semaglutide Initiation: A Case Report司美格鲁肽治疗后快速减重诱发正常甲状腺病态综合征：一例病例报告DOI: 10.1177/11795514261443862
RSC advances IF: 04.600Volume 16, Issue 24No.191Bacterial metabolite-directed synthesis of biogenic TiO(2)-Zn nanocomposites: characterization and multifunctional biomedical evaluation细菌代谢物导向合成生物源TiO₂-Zn纳米复合材料：表征与多功能生物医学评价DOI: 10.1039/d6ra00881j
Frontiers in chemistry IF: 04.200Volume 14, Issue No.192Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agentsSymphyotrichum squamatum的植物化学谱系及多靶点药理学评价揭示其作为抗糖尿病和抗炎药物来源的潜力DOI: 10.3389/fchem.2026.1734411
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.193Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria哮喘与慢性阻塞性肺疾病重叠（ACO）：基于诊断标准的患病率和共病因素系统综述DOI: 10.1080/20523211.2026.2654490
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.194The prevalence and predictor factors of urinary tract infection in type 2 diabetes mellitus patients receiving SGLT2 inhibitors in Qatar: A retrospective cohort study卡塔尔2型糖尿病患者使用SGLT2抑制剂后尿路感染的患病率及预测因素：一项回顾性队列研究DOI: 10.1080/20523211.2026.2645913
Frontiers in public health IF: 03.400Volume 14, Issue No.195Central adiposity outperforms disordered eating behavior in predicting type 2 diabetes risk in young adults: an explainable machine learning approach中心性肥胖在预测年轻人2型糖尿病风险方面优于饮食行为紊乱：一项可解释机器学习方法DOI: 10.3389/fpubh.2026.1778156
Frontiers in public health IF: 03.400Volume 14, Issue No.196Correction: Influence of the COVID-19 pandemic on chronic disease management among indigenous people in Canada更正：COVID-19大流行对加拿大原住民慢性病管理的影响DOI: 10.3389/fpubh.2026.1817733
Int J Microbiol IF: 03.200Volume 2026, Issue No.197Coevolution of Human Diet and Gut Microbiome: Implications for Nutrigenomics and Cross-Population Health人类饮食与肠道微生物组的共同进化：对营养基因组学和跨人群健康的影响DOI: 10.1155/ijm/5597426
Germs IF: 01.700Volume 16, Issue 1No.198Variety of Clostridioides difficile Ribotypes in CDI Patients in Las Vegas, NV内华达州拉斯维加斯CDI患者中艰难梭菌核糖体类型的多样性DOI: 10.3390/germs16010002
Curēus IF: 01.300Volume 18, Issue 3No.199Elevated Lipoprotein(a) and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Systematic Review经皮冠状动脉介入治疗后脂蛋白(a)升高与心血管结局：一项系统评价DOI: 10.7759/cureus.106009
Curēus IF: 01.300Volume 18, Issue 3No.200Early-Remitting Neonatal Diabetes in a Growth-Restricted Preterm Infant Requiring Insulin: A Case Report生长受限早产儿需胰岛素治疗的早期缓解型新生儿糖尿病：一例病例报告DOI: 10.7759/cureus.106025
Frontiers in physiology IF: 03.400Volume 17, Issue No.201Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition血清素系统调节恢复营养过剩诱导肥胖大鼠脑和心脏的氧化平衡与基因表达DOI: 10.3389/fphys.2026.1783080
Frontiers in medicine IF: 03.000Volume 13, Issue No.202Systemic strategies to prevent early diabetic retinopathy: targeting polyunsaturated fatty acid metabolism and eicosanoid signaling预防早期糖尿病视网膜病变的系统性策略：靶向多不饱和脂肪酸代谢和类花生酸信号DOI: 10.3389/fmed.2026.1802443
J Clin Exp DentVolume 18, Issue 3No.203Nonsurgical Periodontal Therapy for Diabetes Patients with Periodontal Disease非手术牙周治疗对伴有牙周病的糖尿病患者的疗效DOI: 10.4317/jced.63729
J Public Health ResVolume 15, Issue 2No.204Understanding community needs: Comprehensive analysis of the family adoption program conducted in coastal region of South India理解社区需求：印度南部沿海地区家庭收养计划的综合分析DOI: 10.1177/22799036261439972
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.205Relationship between apolipoprotein M levels and diabetic retinopathy in patients with type 2 diabetes mellitus2型糖尿病患者载脂蛋白M水平与糖尿病视网膜病变的关系DOI: 10.3389/fendo.2026.1809680
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.206Dermatologic outcomes associated with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a large-scale target trial emulation胰高血糖素样肽-1受体激动剂与2型糖尿病患者皮肤结局的关联：一项大规模目标试验模拟研究DOI: 10.3389/fendo.2026.1801203
Frontiers in digital health IF: 03.800Volume 8, Issue No.207ChatGPT for diabetes education: potential, accuracy, and accessibility in patient supportChatGPT在糖尿病教育中的应用：患者支持中的潜力、准确性与可及性DOI: 10.3389/fdgth.2026.1768843
bioRxivVolume 2026, Issue No.208Longitudinal in vivo human wound healing model defines key role for smooth muscle cells in ECM remodeling纵向体内人类伤口愈合模型定义平滑肌细胞在细胞外基质重塑中的关键作用DOI: 10.64898/2026.02.24.707845
JCEM case reportsVolume 4, Issue 5No.209Tirzepatide-associated hyponatremia in a patient with known arginine vasopressin deficiency替尔泊肽相关低钠血症在一例已知精氨酸加压素缺乏症患者中的报告DOI: 10.1210/jcemcr/luag110
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.210The therapeutic potential of Vanilla planifolia: how its phytochemicals combat diabetes?香荚兰的治疗潜力：其植物化学物质如何对抗糖尿病？DOI: 10.3389/fphar.2026.1752315
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.211Correction: Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failureα7烟碱型乙酰胆碱受体：靶向炎症、肾素-血管紧张素-醛固酮系统与神经系统之间的相互作用用于心力衰竭的新型治疗DOI: 10.3389/fphar.2026.1841172
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.212The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes嗜铬粒蛋白A裂解产物在1型和2型糖尿病发病中的作用DOI: 10.3389/fcdhc.2026.1812936
Diabetic medicine IF: 03.400Ahead of Print.No.213Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)替普利珠单抗在2型1型糖尿病临床应用的考量：英国儿科内分泌与糖尿病学会和英国临床糖尿病专家协会的共识声明DOI: 10.1111/dme.70329
Diabetic medicine IF: 03.400Ahead of Print.No.214Has the time come for a remission definition in type 1 diabetes? A functional perspective1型糖尿病缓解定义时机已到？功能性视角DOI: 10.1111/dme.70351
Cent Nerv Syst Agents Med ChemAhead of Print.No.215Unveiling the Neuroprotective Role of Nutritional Supplements in Neurodegenerative Diseases揭示营养补充剂在神经退行性疾病中的神经保护作用DOI: 10.2174/0118715249389608251108031453
British journal of nutrition IF: 03.000Ahead of Print.No.216Association between the Mediterranean dietary pattern and Metabolic dysfunction-associated steatotic liver disease (MASLD): A longitudinal analysis from UK BIOBANK地中海饮食模式与代谢功能障碍相关脂肪性肝病的关联：来自英国生物样本库的纵向分析DOI: 10.1017/S0007114526107351
Curr Opin Endocrinol Diabetes Obes IF: 02.700Volume 33, Issue 3No.217Editorial introduction编者按DOI: 10.1097/MED.0000000000000958
Medical decision making : IF: 02.300Ahead of Print.No.218A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data基于微观模拟的慢性肾脏病数据社会偏见缓解方法DOI: 10.1177/0272989X261432162
The journal of dermatology IF: 02.700Ahead of Print.No.219Drug-Induced Blaschkitis Associated With Dipeptidyl Peptidase-4 Inhibitor: A Case Report and Review of the Literature二肽基肽酶-4抑制剂相关药物诱导的Blaschkitis：病例报告及文献综述DOI: 10.1111/1346-8138.70296
Diabetes Technol Ther IF: 06.300Ahead of Print.No.220Safety and Effectiveness of MiniMed™ 780G Advanced Hybrid Closed-Loop Use with Ultrarapid Insulin Lispro-AABC in Pediatric and Adult Type 1 DiabetesMiniMed™ 780G高级混合闭环系统联合超速效胰岛素赖脯-aabc在儿童和成人1型糖尿病患者中的安全性和有效性DOI: 10.1177/15209156261444994
BMC nutrition IF: 02.200Ahead of Print.No.221Dietary advanced glycation end products and risk of cardiometabolic disorders in older adults: cross-sectional data from the 2007-2021 Korea National Health and Nutrition Examination Survey (KNHANES)膳食晚期糖基化终末产物与老年人心脏代谢疾病风险：基于2007-2021年韩国国家健康与营养调查的横断面数据DOI: 10.1186/s40795-026-01334-z
Frontiers in public health IF: 03.400Volume 14, Issue No.222Comprehensive assessment of health disparities in tribal and non-tribal population in India: a sex- and age-stratified cross-sectional study印度部落与非部落人群健康差异的综合评估：一项按性别和年龄分层的横断面研究DOI: 10.3389/fpubh.2026.1772205
Current drug metabolism IF: 01.800Ahead of Print.No.223Formulation and Characterization of CCD-based Optimized Geraniol-loaded Antidiabetic Niosomes基于CCD优化的香叶醇负载抗糖尿病囊泡的制备与表征DOI: 10.2174/0113892002382359251122043509
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.224Investigation of the nitric oxide signaling pathway induced by ezetimibe on renal injury in streptozotocin-induced diabetic rat: role of anti-oxidative and anti-inflammatory effects依折麦布诱导一氧化氮信号通路对链脲佐菌素诱导的糖尿病大鼠肾损伤的作用：抗氧化和抗炎效应的研究DOI: 10.1080/08923973.2026.2657952
Critical care IF: 09.300Volume 30, Issue 1No.225Interpreting metformin safety: the importance of context, selection, and monitoring解读二甲双胍安全性：背景、选择与监测的重要性DOI: 10.1186/s13054-026-06050-5
Curēus IF: 01.300Volume 18, Issue 3No.226THR-β Agonists vs Incretin Therapies for Noncirrhotic Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Biopsy-Anchored Systematic Review With Grading of Recommendations Assessment, Development and Evaluation (GRADE) CertaintyTHR-β激动剂与肠促胰素疗法治疗非肝硬化性代谢功能障碍相关脂肪性肝炎：一项基于活检的系统评价与GRADE证据确定性评估DOI: 10.7759/cureus.106038
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.227Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications单核细胞在HIV相关动脉粥样硬化中的作用：发病机制与临床意义综述DOI: 10.22088/cjim.17.1.1
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.228Investigating subclinical myocardial ischemia by measuring carotid intima-media thickness using Doppler Ultrasound in patients with acute cardiac ischemia通过多普勒超声测量颈动脉内膜中层厚度研究急性心肌缺血患者的亚临床心肌缺血DOI: 10.22088/cjim.17.1.97
Trials IF: 02.000Ahead of Print.No.229Optimizing metabolic management on integrase-based ART (OPTIMAR): study protocol for a 2 × 2 factorial, randomised, double-blind placebo-controlled trial to compare the addition of dapagliflozin versus placebo, and rosuvastatin plus ezetimibe versus pitavastatin, in people with HIV on integrase strand transfer inhibitor-based antiretroviral therapy with elevated metabolic risk优化基于整合酶的抗逆转录病毒治疗中的代谢管理（OPTIMAR）：一项2×2析因、随机、双盲、安慰剂对照试验方案，比较在具有高代谢风险的HIV感染者中加用达格列净与安慰剂，以及瑞舒伐他汀联合依折麦布与匹伐他汀的效果DOI: 10.1186/s13063-026-09723-2
RSC advances IF: 04.600Volume 16, Issue 24No.230Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis新型哌嗪-三唑杂合物作为PTP1B和α-淀粉酶抑制剂：合成、生物学评价及通过网络药理学、分子对接、MD模拟、DFT和MMPBSA分析的计算验证DOI: 10.1039/d6ra00931j
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.231Long-term prognosis of coexistent metabolic dysfunction–associated steatotic liver disease and chronic kidney disease following acute myocardial infarction急性心肌梗死后共存代谢功能障碍相关脂肪性肝病与慢性肾脏病的长期预后DOI: 10.1007/s00392-026-02925-3
JSCAIAhead of Print.No.232Expanding Anatomical Feasibility of CardioMEMS Implantation: A Case Report of Successful Implantation in a Patient With Significant Morbid Obesity扩展CardioMEMS植入的解剖可行性：一例重度肥胖患者成功植入的病例报告DOI: 10.1016/j.jscai.2026.105319
236
Diabetes Mellitus(DM)
糖尿病
93
Obesity
肥胖症
63
Insulin
胰岛素
27
Type 2 diabetes mellitus(T2DM)
2型糖尿病
14
Metabolic Syndrome
代谢综合征
14
Diabetic Foot
糖尿病足
12
Metformin
二甲双胍
11
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
11
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
11
Diabetic Retinopathy
糖尿病视网膜病
9
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
8
Diabetic Neuropathies
糖尿病性神经病变
7
Semaglutide
司美格鲁肽
7
Hypoglycemic Agents
降糖药
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Tirzepatide
替尔泊肽
5
Diabetes Complications
糖尿病并发症
5
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
4
Pregabalin
普瑞巴林
4
Dapagliflozin
达格列净
2
Ertugliflozin
艾托格列净
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Liraglutide
利拉鲁肽
2
Sitagliptin
西他列汀
2
Gabapentin
加巴喷丁
2
Diabetic acidosis
糖尿病性酸中毒
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
Painful Diabetic Peripheral Neuropathy(PDPN)
痛性糖尿病周围神经病变
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Canagliflozin
卡格列净
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
编辑：韩玉莲
审校：韩玉莲
100 项与 普瑞巴林 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 纤维肌痛 | 韩国 | 2005-06-14 | |
| 癫痫发作 | 澳大利亚 | 2005-04-13 | |
| 糖尿病周围神经病变 | 美国 | 2004-12-30 | |
| 疱疹后神经痛 | 美国 | 2004-12-30 | |
| 疱疹后神经痛 | 美国 | 2004-12-30 | |
| 癫痫部分性发作 | 欧盟 | 2004-07-05 | |
| 癫痫部分性发作 | 冰岛 | 2004-07-05 | |
| 癫痫部分性发作 | 列支敦士登 | 2004-07-05 | |
| 癫痫部分性发作 | 挪威 | 2004-07-05 | |
| 癫痫 | 欧盟 | 2004-07-05 | |
| 癫痫 | 冰岛 | 2004-07-05 | |
| 癫痫 | 列支敦士登 | 2004-07-05 | |
| 癫痫 | 挪威 | 2004-07-05 | |
| 广泛性焦虑障碍 | 欧盟 | 2004-07-05 | |
| 广泛性焦虑障碍 | 冰岛 | 2004-07-05 | |
| 广泛性焦虑障碍 | 列支敦士登 | 2004-07-05 | |
| 广泛性焦虑障碍 | 挪威 | 2004-07-05 | |
| 神经痛 | 欧盟 | 2004-07-05 | |
| 神经痛 | 冰岛 | 2004-07-05 | |
| 神经痛 | 列支敦士登 | 2004-07-05 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 下肢溃疡 | 临床3期 | 美国 | 2015-05-15 | |
| 幻肢 | 临床3期 | 美国 | 2015-05-15 | |
| 难治性慢性咳嗽 | 临床3期 | 澳大利亚 | 2012-02-28 | |
| 强直阵挛性癫痫 | 临床3期 | 美国 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 中国 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 白俄罗斯 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 比利时 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 波斯尼亚和黑塞哥维那 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 保加利亚 | 2012-02-21 | |
| 强直阵挛性癫痫 | 临床3期 | 捷克 | 2012-02-21 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床4期 | 83 | pregabalin+epinephrine+ropivacaine+acetaminophen+magnesium+oxycodone extended-release+ketorolac+dexamethasone+ibuprofen+celecoxib+tizanidine (Non Opioid, Multimodal Protocol) | 簾壓膚鹽醖鏇夢築蓋鹽(廠顧範餘選鬱獵鹹淵築) = 簾鏇積衊觸顧壓夢築憲 願積顧艱齋築鹽鑰選醖 (鹽築醖顧醖繭網鹽遞鬱, 1.7) | - | 2026-02-10 | ||
pregabalin+epinephrine+ropivacaine+acetaminophen+magnesium+oxycodone extended-release+ketorolac+dexamethasone+ibuprofen+celecoxib+tizanidine (Opioid Protocol) | 簾壓膚鹽醖鏇夢築蓋鹽(廠顧範餘選鬱獵鹹淵築) = 餘壓蓋鹹夢觸衊簾廠襯 願積顧艱齋築鹽鑰選醖 (鹽築醖顧醖繭網鹽遞鬱, 1.6) 更多 | ||||||
临床4期 | 109 | (Pregabalin) | 鏇夢憲觸蓋糧淵餘鹹製(衊蓋構醖鹹糧簾願範顧) = 獵淵簾襯顧糧淵築憲鹹 簾鏇鹽鏇顧壓範夢構積 (遞蓋衊壓繭築廠憲積遞, 鬱顧鹹醖鹽遞觸選鏇構 ~ 遞遞鹹壓顧獵醖顧觸繭) 更多 | - | 2026-01-06 | ||
(Gabapentin) | 鏇夢憲觸蓋糧淵餘鹹製(衊蓋構醖鹹糧簾願範顧) = 鹹鹹衊鬱鏇製膚糧繭構 簾鏇鹽鏇顧壓範夢構積 (遞蓋衊壓繭築廠憲積遞, 鏇齋積鏇範壓構糧範製 ~ 選選齋鑰夢築積觸襯蓋) 更多 | ||||||
N/A | 179,684 | 餘構壓選鹽獵鹹網構蓋(醖築廠積壓範艱壓觸衊): HR = 1.23 (95.0% CI, 1.08 ~ 1.4) 更多 | 不佳 | 2025-10-24 | |||
临床4期 | 84 | (Preoperative Adductor Canal Block Group) | 廠窪遞網鏇鑰糧積糧鏇(顧網鹹壓範願淵襯鏇夢) = 範廠壓壓齋簾醖網糧選 襯蓋獵願齋齋壓鏇醖憲 (鹽夢鏇選廠襯窪繭範選, 鹽艱鹹選壓襯窪餘構製 ~ 艱鹹鹹鹽繭糧簾顧網廠) 更多 | - | 2025-02-12 | ||
(Postoperative Adductor Canal Block Group) | 廠窪遞網鏇鑰糧積糧鏇(顧網鹹壓範願淵襯鏇夢) = 壓繭窪膚鬱範膚醖願蓋 襯蓋獵願齋齋壓鏇醖憲 (鹽夢鏇選廠襯窪繭範選, 鹹網網遞餘窪鬱簾壓築 ~ 鑰網鏇鬱鏇願鹹齋膚構) 更多 | ||||||
N/A | 179,562 | 顧淵願願餘衊積簾積艱(淵顧窪鏇遞醖獵築繭壓) = 衊觸壓壓醖構簾鏇鏇齋 鏇鬱憲觸壓範鏇壓衊憲 (選鏇糧蓋鑰網襯醖簾選 ) | 不佳 | 2024-11-10 | |||
顧淵願願餘衊積簾積艱(淵顧窪鏇遞醖獵築繭壓) = 窪淵餘築鹽鏇鑰願淵簾 鏇鬱憲觸壓範鏇壓衊憲 (選鏇糧蓋鑰網襯醖簾選 ) | |||||||
临床2/3期 | 118 | (Pregabalin 300mg) | 廠窪築襯願窪顧簾遞醖(顧醖網鏇範鏇顧襯築範) = 窪鹽繭鹹構齋範鏇壓願 鏇積範艱鏇廠蓋衊構鏇 (蓋選齋簾壓廠顧選遞窪, 糧蓋糧積糧網構齋餘窪 ~ 遞鏇觸襯構壓襯淵願膚) 更多 | - | 2024-10-24 | ||
Placebo oral tablet (Placebo) | 廠窪築襯願窪顧簾遞醖(顧醖網鏇範鏇顧襯築範) = 築壓構醖築蓋構憲網蓋 鏇積範艱鏇廠蓋衊構鏇 (蓋選齋簾壓廠顧選遞窪, 願顧鬱廠顧壓窪願齋衊 ~ 遞繭遞遞網繭夢衊廠廠) 更多 | ||||||
临床4期 | 130 | Sustained-Release Pregabalin 150 mg | 鏇範蓋醖繭繭鹽壓網鬱(蓋鬱壓鑰鹹構艱艱繭選) = 觸鏇簾鹽憲構齋窪鏇衊 觸夢製鏇蓋構鬱簾簾膚 (襯願餘襯鹽襯願積糧築 ) | 积极 | 2024-07-14 | ||
Immediate-Release Pregabalin 75 mg | 鏇範蓋醖繭繭鹽壓網鬱(蓋鬱壓鑰鹹構艱艱繭選) = 網鹹構願膚獵膚鑰鬱衊 觸夢製鏇蓋構鬱簾簾膚 (襯願餘襯鹽襯願積糧築 ) | ||||||
临床4期 | - | 100 | (Multi-modal) | 艱繭鏇築衊鑰繭願鹽鏇(網鏇衊餘壓艱蓋顧鑰簾) = 鏇糧構範鹽壓遞鬱鹽夢 範簾夢積繭鏇醖艱鹽構 (廠襯壓構淵簾廠艱鏇衊, 積膚鹹窪窪鏇鑰構鹹積 ~ 廠築鹽獵齋糧廠廠顧艱) 更多 | - | 2024-07-08 | |
(Control) | 艱繭鏇築衊鑰繭願鹽鏇(網鏇衊餘壓艱蓋顧鑰簾) = 鏇齋鹽繭淵夢願鬱鹽膚 範簾夢積繭鏇醖艱鹽構 (廠襯壓構淵簾廠艱鏇衊, 築鹽選齋鬱鏇膚蓋簾憲 ~ 鑰構範繭憲繭鑰廠餘膚) 更多 | ||||||
临床2期 | 90 | 鏇繭鑰簾艱構繭簾築簾(膚繭鹽觸壓餘獵網衊鹽) = 壓壓鹹壓觸範簾鹽顧膚 願衊糧鏇築壓壓醖願壓 (鏇襯鹹壓夢獵鬱襯鏇襯, 4.6) 更多 | - | 2024-05-20 | |||
Placebo oral tablet+Lofexidine 0.18Mg Tab (Lofexidine and PLACEBO) | 鏇繭鑰簾艱構繭簾築簾(膚繭鹽觸壓餘獵網衊鹽) = 齋窪醖淵窪鏇壓鏇糧齋 願衊糧鏇築壓壓醖願壓 (鏇襯鹹壓夢獵鬱襯鏇襯, 5.1) 更多 | ||||||
临床3期 | 57 | BBCET+Pregabalin (Pregabalin + BBCET) | 獵積憲艱廠願遞簾願觸(構觸鹹鹹膚鏇範鑰範衊) = 餘齋網蓋蓋憲廠製餘鹽 夢糧願鏇窪簾鹽構積夢 (鏇製構壓積憲窪繭顧艱, 13.1) 更多 | - | 2024-03-13 | ||
Placebo (Placebo + BBCET) | 獵積憲艱廠願遞簾願觸(構觸鹹鹹膚鏇範鑰範衊) = 壓範膚艱醖簾構網願鹽 夢糧願鏇窪簾鹽構積夢 (鏇製構壓積憲窪繭顧艱, 11.2) 更多 |
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