This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

开始日期2025-03-01

申办/合作机构

Yale University

[+1]

NCT05932693

/ RecruitingN/AIIT

Examine the Effects of Novel E-cigarette Constituents and Determining Appropriate Concentrations Among Adults

This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.

开始日期2024-09-03

申办/合作机构

Yale University

[+1]

NCT06444594

/ Not yet recruiting早期临床1期IIT

Transient Receptor Potential Channels in Human Skin

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

开始日期2024-06-15

申办/合作机构

The Pennsylvania State University

100 项与薄荷脑相关的临床结果

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100 项与薄荷脑相关的转化医学

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100 项与薄荷脑相关的专利（医药）

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2,861

项与薄荷脑相关的文献（医药）

2025-02-01·Intensive and Critical Care Nursing

Thirst in adult patients in the intensive care unit: A scoping review

Review

作者: Spronk, Peter E ; Spronk, Peter E. ; Flim, Marleen ; Rustøen, Tone ; Blackwood, Bronagh

PURPOSE:

To review the literature on thirst in intensive care unit (ICU) patients and report potential causes, risk factors, diagnosis and measurement tools, as well as potential co-occurrence with other distressing symptoms, and the management of thirst in the ICU.

DESIGN:

A scoping review employing the Joanna Briggs Institute methodology.

METHODS:

PubMed, MEDLINE, EMBASE and CINAHL were searched from inception to April 2024. Any type of empirical study reporting thirst or associated xerostomia in adult patients (≥18 years) admitted to an ICU or high dependency unit for more than 24 h were included.

RESULTS:

The search yielded 907 unique records, and after evaluating 65 full-text publications, 21 studies were included. Thirst intensity was addressed most often (eleven studies), whereas the experience (or quality) of thirst and the validation of a measurement instrument, were addressed in only one study. Although co-occurrence of symptoms was addressed in four studies, only one pilot study looked into the interaction of thirst with other symptoms. Intervention studies have been focussing primarily on mouth-care interventions.

CONCLUSION:

Thirst is a distressing symptom in the ICU, with reported high prevalence and intensity. Knowledge about its causes, interventions that incorporate minimising its risk, occurrence and intensity are limited.

IMPLICATIONS FOR CLINICAL PRACTICE:

Health care providers should acknowledge thirst as a prominent symptom for ICU patients. They should possess knowledge on the factors that potentially evoke or aggravate thirst. Regular and timely relief of thirst by oral care with cold swabs and the application of menthol can be regarded as a first choice of intervention.

2025-02-01·NEUROPHARMACOLOGY

Neural modulation by nicotine aerosols and the role of flavor additives: insights from local field potentials in mice

Article

作者: Zhu, Yunhe ; Shi, Qingzhao ; Mao, Jian ; Wang, Junmin ; Chai, Guobi ; Li, Ying ; Hu, Nengwei ; Sun, Jingping ; Xie, Jianping ; Fan, Wu ; Zhang, Qidong

Research on nicotine's neurobiological effects has rarely focused on aerosols, despite their primary role in tobacco product consumption. Here, we utilized in vivo electrophysiology to examine brain activity in mice exposed to nicotine aerosols, both alone and with flavor additives (citric acid and menthol). Local field potential (LFP) recordings from the nucleus accumbens (NAc), basolateral amygdala (BLA), ventral tegmental area (VTA), and ventral posteromedial nucleus (VPM) were analyzed under saline, nicotine, nicotine with citric acid(CA + NIC), and nicotine with menthol(MENT + NIC) conditions. Nicotine exposure significantly reduced power spectral density (PSD) in the NAc-Alpha, NAc-Beta, and BLA-Beta bands, unaffected by flavor additives. Coherence between key brain regions (e.g., VPM-VTA in Beta, VPM-BLA in Alpha) also decreased with nicotine but was restored with citric acid or menthol, suggesting their role in mitigating nicotine's disruptive effects on neural synchronization. Our findings show that LFPs can effectively capture nicotine's neural effects and highlight the modulatory role of flavor additives, offering new insights into nicotine exposure management and tobacco product design.

2025-01-01·BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural terpenes II. Concentration-dependent profile of effects on dynamic organization of biological and model membranes

Article

作者: Turina, A V ; Perillo, M A ; Clop, E M

Monoterpenes (MTs), the major constituents of plant essential oils, cover a broad spectrum of biological activities through their interaction with biomembranes. MTs are highly hydrophobic substances with a net electrical dipole, but are not clearly amphipathic. As a result, they aggregate at increasing concentrations in aqueous media, and in membrane environments their behavior changes from dynamics modulators to disruptors. In the present work we have tried to find the boundaries between these conditions. Using spin-label electron paramagnetic resonance (EPR) spectroscopy, we studied the effect of a wide range of concentrations of camphor, cineole, thymol, menthol and geraniol on the dynamics of phospholipid model membranes, with or without cholesterol, organized in different initial lyotropic phases, as well as on synaptosomal membranes from bovine brain cortex. EPR spectra of two fatty acid spin probes incorporated into the membranes (5-SASL and 12-SASL) provided information on molecular order and mobility at different bilayer depths. Qualitative changes in the spectra indicated transitions between monomeric and aggregated MTs, as well as membranes with different degrees of order and disrupted membranes. Analyzed in conjunction with the kinetics of [³H]flunitrazepam membrane binding, either non-specifically to the membrane or specifically to the GABA_A receptor, the present results allowed us to define 200 μM as the concentration limit to safely evaluate MT effects in non-disrupted biological and model membranes. These findings may be helpful in the interpretation and design of pharmacological assays and provide concentration references that allow correlating a variety of biophysical and pharmacological data in the literature.

项与薄荷脑相关的新闻（医药）

2024-12-25

·药研

色谱技术在药物分析检测中的应用

（点击图片查看详情）摘要色谱技术是现代分析化学中一项重要的分析技术，在石油化工、生物医药、环境保护、食品工业多个领域得到广泛应用。因其具备快速高效、灵敏准确的优点，在药物研发、杂质分析、含量测定等方面广泛应用，为药物分析检测提供了重要的技术支持。随着科技不断进步，制药行业飞速发展，越来越多的药品经研发生产上市，用于人们疾病的预防及治疗。药品是人类防病治病、保证机体健康必不可少的特殊商品，这要求必须保证药品的安全性和有效性，药品生产企业和监管部门须对药品质量进行严格控制监管。目前，市场上药品种类繁多，质量不一，使用科学合理的药物分析技术，加强药品的质量检验，保证药品质量，对药品生产企业长远发展和人们生命健康至关重要。在药品分析检测中，色谱技术因具备快速高效、灵敏准确的优点，在药物研发、杂质分析、含量测定方面广泛应用。目前，色谱法已成为中国药典中收载品种使用最多的现代分析方法[1]。本文通过对色谱技术发展概况及其在药物分析检测中的应用进行研究总结，以期对药物分析检测方法的选择提供一定的参考。 1 色谱技术发展概况 20 世纪初，俄国植物学化学家茨维特发现并提出利用吸附原理分离植物色素的方法，并将其命名为色谱法。其后20 多年色谱技术发展缓慢。直至20 世纪40 年代，英国化学家Martin 等科学家逐渐建立了分配色谱的基础理论，并广泛用于多种有机物的纯化分离。Martin 和Synge 等对使用气体流动相代替液体流动相的可行性进行研究，提出了气液色谱设想。1952 年James 和Martin以自动滴定仪为检测器，使用气相色谱仪成功分离测定脂肪酸混合物，创立气- 液色谱法[2]。1954 年Ray 对热导计的提出，开创了气相色谱新时代。气相色谱的发展极大地推动了色谱技术的发展。这一时期，色谱理论、仪器、数据分析等方面得到飞跃式发展，奠定了现代色谱技术的基础。20 世纪60 年代，由于气相色谱的局限性，人们将气相色谱应用理论和经验用于液相色谱研究，研制发明高效液相色谱，极大地提高了液相色谱的效能，扩大了色谱技术的应用范围。随着化学工业特别是石油化工以及生物医药产业的飞速发展，色谱技术不断完善和改进，气相色谱、高效液相色谱、薄层色谱、离子色谱等成为分析测试的重要工具，色谱法成为必不可少的分析方法。 2 色谱技术的应用 2.1 薄层色谱法（TLC）薄层色谱法是将一定浓度的待测溶液点于合适薄层板上，置展开缸中用合适的展开剂展开，使待测成分分离。该色谱方法的影响因素较多，包括供试样品及对照品的处理制备、薄层板吸附剂的选择、点样技术、展开剂的选择以及实验温度等。因其操作简单快速，使用成本较低，在色谱法发展初期应用较多，是一种比较经典的色谱方法。在药物分析中，薄层色谱法可用于药物鉴别、杂质检查等。用于药物杂质检查时，可采用杂质对照品法或者供试品溶液自身稀释对照法，也可两法并用。供试品溶液的杂质斑点与杂质对照品溶液相应斑点比较，不得更深；或者与自身稀释对照溶液主斑点比较，不得更深。用于药物鉴别时，通常是将供试品溶液和对照品溶液点样于同一薄层板，展开、检视，通过比较供试品和对照品所显斑点的位置、颜色或者荧光是否一致来进行鉴别。该鉴别方法在化学药品中常用于活性药物成分的鉴别，也可用于中药材的鉴别。在巢颖欣[3] 等采用薄层色谱法鉴别陈皮的实验中，供试品色谱在与对照品色谱对应的位置显示相同颜色的斑点，广陈皮均显明显的2- 甲氨基-苯甲酸甲酯斑点，其中14 批陈皮与广陈皮差异较大，均无明显的2- 甲氨基- 苯甲酸甲酯斑点，可见该方法可快速鉴别广陈皮与陈皮。 2.2 高效液相色谱法（HPLC）高效液相色谱法是在高压输液泵作用下，供试品随流动相进入色谱柱中，不同组分在柱内被分离，依次流出进入检测器检测。仪器由高压输液泵、色谱柱、进样器、检测器、数据处理系统等部分组成。该方法具有灵敏度高、检测速度快，专属性强的特点，在药物活性成分鉴别、有关物质检查及含量测定中应用广泛，中国药典中收载的品种越来越多地采用该方法进行检测。在23 版美国药典中采用高效液相色谱法的收载项目已达2000 多项[4]。该方法用于药物鉴别时，常用的有两种方法：一是采用保留时间定性，在规定的色谱条件下，比较供试品和对照品的色谱峰保留时间的一致性来进行鉴别定性；二是通过采用二极管阵列检测器得到供试品和对照品的光谱图，比较光谱图的相似性来定性分析。在用于药物的有关物质检查时，目前药物质量标准中最常用的是外标法和主成分自身对照法，两种方法单独或者结合使用。张晓晓[5] 等建立高效液相色谱法测定盐酸阿罗洛尔工艺合成过程中产生的副产物和中间体等有关物质，采用自身对照法对各有关物质进行检测。主成分与各有关物质之间分离度良好，各杂质均能有效检出，该方法专属性强，灵敏度高，稳定性好，准确简便，可用于该药物的质量控制。用于药物含量测定时，常用方法包括外标法和内标法。采用内标法测定药物含量，能避免样品前处理、进样量、仪器波动等因素对测定结果的影响。推荐｜如何用新版ICH Q2和Q14指导你的分析开发和验证？ 2.3 气相色谱法（GC）气相色谱法是以气体作为流动相，被测物质气化后随流动相进入色谱柱中各组分配分离，先后进入检测器被检测。仪器由载气源、进样系统、色谱分离系统、温度控制系统、检测系统等部分组成，进样方式包括顶空进样和溶液直接进样。具有快速高效、选择性好、样品需求量小的特点。目前常用于热稳定性好和易挥发物质的定性、定量分析。测定法主要包括外标法、内标法。在药物分析检测中，主要应用于中药制品的农药残留、挥发性成分检测、化学药品的溶剂残留检测等。左军凤[6]等研究介绍了气相色谱方法对31 批次中药制剂中11 种挥发性成分进行含量测定，有7 批次中药制剂中检出挥发性成分，主要检出成分有樟脑、薄荷脑、藁本内酯、冰片、芳樟醇、α- 蒎烯、β- 蒎烯。该方法重复性好、准确度高，可用于中药制剂中挥发性成分的测定。 2.4 离子色谱法（IC）离子色谱法是在高压输液泵作用下，可解离物质随洗脱液进入色谱柱后不同物质被分离，先后进入检测器检测。通常用于无机阴、阳离子，有机酸，氨基酸，糖蛋白，氨基糖类等的定性定量分析。根据其分离原理可分为离子交换色谱法、离子对色谱法、离子排阻色谱法等。常用测定法包括外标法、内标法。邢雪敏等[7] 等建立离子色谱法，采用抑制电导检测法，测定布洛芬原料药中2- 氯丙酸根及2,2- 二氯丙酸根的含量。方法操作简单快捷，准确可靠，适用于布洛芬原料中2- 氯丙酸根离子和2,2- 二氯丙酸根离子的含量测定。时佩等[8] 等采用离子色谱法，测定样品中氯离子含量，转化为氯化铵的含量，与容量法测定结果相比，该方法专属性强，准确度高，得出的数据更为集中且异常值明显减少，可以更好地控制产品质量。 3 色谱联用技术的应用色谱联用技术将色谱的高效能分离能力与能够获得化学结构信息的光谱技术结合，具有更高的灵敏度和专属性，有定性定量双重优势。在食品药品、环境化工等领域应用越来越广泛。目前，随着药物分析检测技术要求不断提高，液相色谱- 质谱联用技术（LC-MS）、气相色谱- 质谱联用技术（GC-MS）等在药物分析中的应用逐渐增多，弥补了色谱分析技术的不足，为药品质量控制提供了更好的技术支持。 3.1 液相色谱-质谱联用法（LC-MS）液相色谱- 质谱联用法是将液相色谱的物质分离能力与质谱的结构鉴定能力结合在一起，可对药品中已知物质进行定量分析，也可对未知杂质进行定性和鉴别。主要用于测定极性、对热不稳定以及大分子化合物等，待测样品处理简便快捷，具有灵敏度高、专属性强的特点。能够同时提供被测物质的保留时间、分子量以及特征结构信息等，在药物杂质定性定量分析中发挥着重要作用。周晓迪[9] 等采用超高效液相色谱串联四极杆飞行时间质谱仪对盐酸阿霉素中特殊杂质进行分析测定，发现一种尚未报道过的杂质，对其进行多级质谱解析，并结合盐酸阿霉素生产工艺，推测出该杂质来源及其结构。 3.2 气相色谱-质谱联用法（GC-MS）气相色谱- 质谱联用法是将气相色谱的高效分离能力与质谱的结构鉴定能力相结合，可用于药品中挥发性物质的分离、定性和定量分析。目前广泛应用于化学药品和中药制剂中挥发性成分的检测。因其具备良好的分离性能、准确度和灵敏度，越来越多地应用于药物真伪鉴别、质量控制、痕量基因毒性杂质的检测，为药物质量安全提供了有效技术支撑。陈忆铃[10] 等研究介绍了气质联用技术结合不同样品前处理方法在卤代烷烃、磺酸酯、环氧化物、芳香胺和肼类化合物5 种基因毒性杂质检测中的应用，说明气质联用技术可实现痕量基因毒性杂质的快速分析。 4 结语随着分析技术不断发展，色谱技术在仪器和数据处理方面不断提升和创新，变得更加智能化、微量化，大大提高了药物分析检测效率和分析结果的准确性，在药品检测和质量控制中的应用越来越广泛。尤其是在药物的鉴别、杂质控制、含量测定等方面发挥着重要作用，为保证药品质量提供了无可替代的技术支持。参考文献 1.张伟, 黄金林. 现代分析技术在中药药效成分检测中的应用进展[J]. 化学分析计量,2023,32(9):116-120. 2.BARTLE K D, MYERS P. History of gas chromatography[J].Trends in Analytical Chemistry, 2002, 21(9): 547-557. 3.巢颖欣, 刘梦诗, 杨秀娟, 等. 薄层色谱法快速鉴别广陈皮与陈皮[J]. 中成药,2021,43(7):1937-1940. 4.Gholap V V,Kosmider L,Halquist M S.A Standardized Approach to Quantitative Analysis of Nicotine in e-Liquids Based on Peak Purity Criteria Using High-Performance Liquid Chromatography[J].J Anal Methods Chem,2018(2018):1-11. 5.张晓晓, 史校东, 范甜. 高效液相色谱法测定盐酸阿罗洛尔有关物质[J]. 河北师范大学学报, 2018,42(6):509-514. 6.左军凤, 熊马剑, 朱碧君. 气相色谱法测定中药制剂中11种挥发性成分的含量[J]. 药品评价, 2022,19(13):785-789. 7.邢雪敏, 刘葵葵, 李欣, 等. 离子色谱法测定布洛芬原料药中2- 氯丙酸根及2,2- 二氯丙酸根的含量[J]. 中南药学,2023,21(9):2463-2465. 8.时佩, 鲁寅生, 冯有龙, 等. 离子色谱法测定小儿止咳糖浆中氯化铵的含量[J]. 中国现代应用药学, 2022,39(12):1637-1639. 9.周晓迪, 张先静, 惠人杰. 基于多级质谱分析技术的盐酸阿霉素中特殊杂质分析[J]. 广州化工, 2023,51(3):160-162. 10.陈忆铃, 冯芳. 气质联用技术在基因毒性杂质检测中的应用进展[J]. 广州化工, 2020,48(5):21-23+81. ------------THE END------------ 内容来源：科研技术 2024年11月点击查看：投稿获丰厚稿费（24年6月起执行）

2024-11-05

·drugs

Banning Menthol Cigarettes Might Drive Smokers to Quit-Smoking Therapies

TUESDAY, Nov. 5, 2024 -- Banning menthol cigarettes could help convince smokers quit the habit, a new study finds. People who prefer menthol cigarettes would rather buy nicotine gum or other nicotine replacement therapies than switch to traditional tobacco cigarettes, researchers reported recently in the journal Drug and Alcohol Dependence . In addition, menthol cigarette smokers were less likely to use e-cigarettes as a substitute if menthol vaping products are also restricted, researchers found. “I think the most important conclusion from this study is that we can improve health outcomes by emphasizing policies that reduce sales of flavored products and increase accessibility of nicotine replacement therapies,” said researcher Roberta Freitas-Lemos , an assistant professor at the Virginia Tech Fralin Biomedical Research Institute. More than 9 million adults -- about 32% of all smokers -- use menthol cigarettes, researchers said in background notes. Menthol makes smoking easier by reducing the harshness of cigarette smoke and cooling the throat. The Biden Administration has come under fire for delaying a proposed U.S. Food and Drug Administration ban on menthol cigarettes. In a September hearing before Congress, FDA leaders said a menthol ban is still in the works. "It's a priority for us. We followed through rule-making processes and it's presently with the White House and it continues to be a priority for us," Brian King, director of the FDA's Center for Tobacco Products, told a House Energy and Commerce Committee hearing. For the new study, researchers analyzed data from 172 people who smoke cigarettes, including 76 who only smoke menthol cigarettes and 96 who smoke non-menthol cigarettes. They also looked at 91 who use multiple types of tobacco products. The smokers were asked to use an online account to buy tobacco and nicotine products, which included replacement therapies. When menthol cigarettes weren’t available, smokers who prefer menthol were less willing to buy other types of cigarettes. Instead, they turned to nicotine replacement products like patches or gum. The study also found higher demand for high-ventilation cigarettes, which feature filter holes for airflow that make the smoke less harsh. “Cigarettes with ventilation are milder and people think they are less harmful, but it is a false perception,” Freitas-Lemos said in a Virginia Tech news release. Bans of these products could help smokers choose to quit, the researchers concluded. “It could be that people who smoke ventilated cigarettes are more responsive to one ban than another,” Freitas-Lemos said. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

2024-09-24

·PRNewswire

Stop Itchy Skin in its Tracks

5 tips for relief from a board-certified dermatologist ROSEMONT, Ill., Sept. 24, 2024 /PRNewswire/ -- Itchy skin can be irritating, especially an itch that doesn't go away. There are many potential causes for itchy skin like common skin conditions such as eczema, shingles, hives, psoriasis, or bug bites, or it could be a sign of a contagious disease, like scabies or ringworm. While these causes could mean a visit to a board-certified dermatologist, there are options for self-care at home to provide itch relief. "Our first instinct is to scratch that pesky itch, but in reality, that could be making things worse by irritating your skin further," said Susan Massick, MD, FAAD, clinical associate professor of dermatology at The Ohio State University. "Everyone experiences itchy skin from time to time, but relief can be possible by following a few easy steps at home." To help soothe itchy skin, Dr. Massick and the American Academy of Dermatology recommend following these tips: Apply a cool, damp washcloth to itchy skin for about 5-10 minutes, or until the itch goes away. Take a warm colloidal oatmeal bath. This can soothe your skin, especially if the cause of your itch is chickenpox, hives, poison ivy, or sunburn. Apply a "fragrance-free" moisturizer when your skin is still damp after bathing or whenever it itches. Soaps, detergents, and other products should also be "fragrance-free" as fragrance can irritate the skin. If your moisturizer doesn't relieve the itch, apply a cooling agent, like menthol or calamine. You can also try an over-the-counter cream or gel that contains pramoxine, a topical pain reliever. Sometimes keeping these in the refrigerator also helps. Wear loose-fitting, cotton clothes. These help you stay cool and won't irritate your skin, like wool and other rough-feeling fabrics can. Avoid extreme temperature changes, as these can make itch worse. Keep your house cool during the summer and use a humidifier and avoid high heat in the winter. "If you do not find relief after trying these at-home tips, or if you notice changes to your skin, such as redness, swelling, rash, bumps, or sores, a board-certified dermatologist can diagnose the underlying condition," said Dr. Massick. "Often, itching can have more than one cause, and together we can work toward a treatment plan that offers the best results, healthier skin, and, ultimately, symptom relief." These tips are demonstrated in "How to relieve itchy skin," a video posted to the AAD website and YouTube channel. This video is part of the AAD's "Your Dermatologist Knows" series, which offers tips people can use to properly care for their skin, hair, and nails. To manage itchy skin and learn more tips, partner with a board-certified dermatologist. To find a board-certified dermatologist in your area, visit aad.org/findaderm. More Information Itchy Skin Resource Center 10 Reasons Your Skin Itches and How to Get Relief AAD B-Roll Library About the AAD Headquartered in Rosemont, Ill., the American Academy of Dermatology, founded in 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 21,000 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical, and cosmetic treatment of the skin, hair, and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, TikTok, Pinterest and YouTube and @AADskin1 on Instagram. SOURCE American Academy of Dermatology WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

100 项与薄荷脑相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04918	薄荷脑	R05X	DB14123

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适应症	国家/地区	公司	日期
支气管炎	-	-	-
鼻窦炎	-	-	-

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适应症	最高研发状态	国家/地区	公司	日期
咽炎	临床3期	俄罗斯	Sandoz International GmbH	2017-02-22
腺瘤性结肠息肉病	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
去势抵抗性前列腺癌	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
早期胃癌	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
胃腺瘤	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01855607 (CTgov)	临床2期	结肠癌 \| 乳腺癌 \| 周围神经系统疾病	12	placebo+menthol	鹽範壓築壓齋範窪選構(願鬱蓋鹽鏇廠廠淵鏇窪) = 鑰積壓繭積夢顧鬱鏇遞憲衊衊壓襯艱壓顧膚夢 (觸蓋壓範鑰鬱醖衊窪鑰, 襯簾膚遞艱構齋鏇鬱繭 ~ 築窪廠願簾遞選獵窪獵) 更多	-	2024-07-11
ATS2023	N/A	呼吸功能不全	-	Electronic Cigarette Menthol Flavoring (Menthol-flavored ECs)	壓製艱選糧鏇繭顧餘艱(齋觸獵鬱繭淵鬱膚鬱範) = reduced 糧蓋鏇窪繭襯鬱積鑰糧 (膚窪餘遞鏇顧窪餘淵鑰 ) 更多	-	2023-05-21
				Electronic Cigarette Menthol Flavoring (Non-menthol-flavored ECs)
NCT03095508 (CTgov)	临床3期	咽炎	229	Angal S, topical spray [Menthol] (Angal S (Arm A))	遞構願窪齋齋遞構鹹鏇(糧餘糧憲餘憲觸衊鹹範) = 淵範製製淵廠醖膚繭憲獵蓋糧襯齋廠窪鹽範願 (範淵窪淵網範遞築構鑰, 膚窪憲積膚築繭觸繭齋 ~ 網憲鑰鬱窪鑰繭範鏇願) 更多	-	2019-03-21
				ANTI-ANGIN® FORMULA, topical metered spray (ANTI-ANGIN® FORMULA (Arm B))	遞構願窪齋齋遞構鹹鏇(糧餘糧憲餘憲觸衊鹹範) = 遞簾窪憲築構窪遞簾積獵蓋糧襯齋廠窪鹽範願 (範淵窪淵網範遞築構鑰, 構網艱鹹糧淵遞網遞願 ~ 鹽膚醖襯壓鏇醖鹽廠繭) 更多
NCT02102100 (CTgov)	N/A	尼古丁依赖	57	nicotine+menthol (Menthol-Preferring Smokers)	鹹艱憲鏇範襯夢簾顧積(構築齋製餘鬱淵製衊糧) = 襯積鑰鏇選鏇蓋窪範衊鏇壓網選餘憲構遞範獵 (製夢壓願願鑰夢窪齋獵, 範鏇遞壓顧餘鑰鏇觸遞 ~ 衊壓築鏇顧衊淵憲憲築) 更多	-	2019-02-20
				nicotine+menthol (Non-Menthol Preferring Smokers)	鹹艱憲鏇範襯夢簾顧積(構築齋製餘鬱淵製衊糧) = 網淵鬱積襯膚艱鏇顧繭鏇壓網選餘憲構遞範獵 (製夢壓願願鑰夢窪齋獵, 艱範鹽壓築繭夢築鹽艱 ~ 膚遞選齋襯鏇襯醖顧鏇) 更多
UEGW2014	N/A	消化不良	-	Menthol (Patients with dyspepsia symptoms)	獵憲鹹壓夢夢鹹願艱簾(遞淵製齋構觸鹽夢衊膚) = 壓齋廠顧糧壓醖鏇夢糧夢獵遞衊膚襯範製構簾 (範壓艱壓壓鏇獵齋餘夢 )	-	2014-10-01
				Menthol (Healthy subjects without abdominal symptoms)	獵憲鹹壓夢夢鹹願艱簾(遞淵製齋構觸鹽夢衊膚) = 觸繭構餘窪衊壓網夢鏇夢獵遞衊膚襯範製構簾 (範壓艱壓壓鏇獵齋餘夢 )
SFN2013	N/A	三叉神经损伤	-	menthol (ION-CCI rats)	繭壓廠艱艱範鬱獵廠醖(積遞鹽艱醖繭憲鑰鬱糧) = 鹽顧窪窪簾遞衊壓鏇網襯顧製顧窪選簾鏇獵簾 (鏇選獵壓鹽窪鹽鹹憲艱 )	-	2013-11-12
				menthol (Sham group)	繭壓廠艱艱範鬱獵廠醖(積遞鹽艱醖繭憲鑰鬱糧) = 鏇淵壓糧齋鏇衊繭齋鬱襯顧製顧窪選簾鏇獵簾 (鏇選獵壓鹽窪鹽鹹憲艱 )
SFN2013	N/A	-	-	Menthol	蓋衊醖鹹簾選蓋鑰選獵(膚觸鹹顧願衊壓遞簾膚) = 鑰膚選蓋顧鹽製餘築鹽鹽鑰鹹鹽餘齋繭廠壓醖 (膚築廠積衊積構壓鬱願 )	-	2013-11-12