Tears are the natural way to keep eyes moist, and tears are important for good vision and healthy eyes. Eyes without enought tears get dry and sore.
The natural and normal way to stimulate secretion of tears is by turning on cold sensors that are located on the cornea of the eye. Tear are normally released across the eyeball in a finely balanced system that balances out that natural evaporation. But sometimes there is not enough tear secretion to balance out the evaporation of tears and eyes can get sore.
The aim here is to test whether menthol in its vapor form may possibly turn on those cold sensors and thus cause secretion of tears. Use of menthol vapors may be like having a switch to release more tears.
The aim of this clinical trial is to test the hypothesis that a menthol solution applied onto a cheek will release enough menthol vapor into the air flowing up over the eye's cornea to stimulate cold sensors enough to make a tear flow from the eye.
If the hypothesis that menthol safely stimulates tear secretion in healthy people proves to be correct, then this clinical trial may inspire more new research into the use of menthol as an alternative to the use of eye drops for some people.

开始日期2025-08-17

申办/合作机构

Stearacl Inc

[+1]

NCT05932745

/ RecruitingN/AIIT

Examining Appeal and Addiction Potential of Novel E-cigarette Constituents Among Adults

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

开始日期2025-06-20

申办/合作机构

Yale University

[+1]

NCT07030725

/ Recruiting早期临床1期IIT

Targeted TRPM8 Stimulation and Brown Adipose Tissue Activation in Humans

Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue activation contributes to this rise in the energy expenditure. The overall goal with this project is to determine whether topical menthol application stimulates brown adipose tissue.

开始日期2025-03-27

申办/合作机构

Indiana University

100 项与薄荷脑相关的临床结果

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100 项与薄荷脑相关的转化医学

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100 项与薄荷脑相关的专利（医药）

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6,965

项与薄荷脑相关的文献（医药）

2025-12-01·Toxicology reports

Analysing the acute toxicity of e-cigarette liquids and their vapour on human lung epithelial (A549) cells in vitro

Article

作者: Donnellan, Samantha ; Findlay-Greene, Fern ; Vass, Sharron

The use of alternative tobacco products such as vaping devices has significantly increased over the last 5-years, with the largest increase being amongst 18-25-year-olds. While the quantity of nicotine is tightly regulated, the composition of e-liquid flavourings is largely unregulated, and often absent from product labels. Herein, we compare the toxicity of carrier liquids propylene glycol (PG) & vegetable glycerine (VG) with five popular flavour concentrates: menthol, cherry, butterscotch, vanilla bourbon and tobacco on human alveolar type II cell-like A549 cells. The flavourings were tested in both liquid and vapour form and a vapour assay was developed to assess cytotoxicity of the flavourings. Our results conclude that menthol liquid was the most cytotoxic (LD₅₀ = <0.5 % over a <4 h exposure). Followed by cherry and vanilla bourbon which elicited a similar response at 4 % over 8 h exposure. Tobacco only reached 50 % toxicity at a concentration > 4 % over 24 h exposure. Butterscotch displayed similar toxicity profiles to PG and VG where cytotoxicity exceeded 20 % at 8 % concentration at all time points. The cytotoxicity of menthol was further evaluated as a vapour, with a significant reduction in viable cells and a 5-fold increase in the number of necrotic cells with only 11 % of cells remaining viable after 5 vaping episodes. Analysis revealed the presence of toxic chemicals and heavy metals in the fluids therefore further research is required to fully elucidate the long-term usage of flavourings with vaping devices and the impact this may have on human lung health.

2025-12-01·ADDICTIVE BEHAVIORS

Menthol cigarette alternative products: Awareness, use, and substitution intentions among adults who smoke menthol cigarettes

Article

作者: Morean, Meghan E ; Bold, Krysten W ; Kong, Grace ; Sharma, Akshika ; Kyriakos, Christina N ; Suttiratana, Sakinah C

BACKGROUND:

Menthol cigarette alternative products (e.g., menthol accessories, non-menthol cooling cigarettes) have entered the market and may bypass menthol cigarette restrictions. Understanding awareness, use, and substitution intentions if menthol cigarette sales are prohibited is important for assessing their potential to undermine the public health benefit of such policies.

METHODS:

We conducted a cross-sectional survey in 2023 of N = 116 Connecticut adults who smoked menthol cigarettes (mean age = 33.4, 50.9 % female, 50.9 % Black, 13.8 % Hispanic). We assessed awareness and ever use of menthol cigarette alternative products including menthol accessories (i.e., menthol filter capsules, sprays, cards, filter tips) and non-menthol cooling cigarettes with synthetic coolants. We measured substitution intentions to use each product if menthol cigarettes were restricted. Logistic regression models examined associations between sociodemographic and smoking characteristics and outcomes of awareness, ever use, and substitution intentions.

RESULTS:

Overall, 66.4% were aware of at least one type of menthol accessory, 41.4% had used one, and 80.2% reported substitution intentions if menthol cigarettes were restricted. Moreover, 39.6% were aware of non-menthol cooling cigarettes, 25.9% had used them, and 56.0% reported substitution intentions. Younger age was associated with awareness of menthol accessories and non-menthol cooling cigarettes. Higher nicotine dependence was associated with awareness, ever use, and substitution intentions across all products.

CONCLUSIONS:

We found considerable awareness, ever use, and substitution intentions of menthol cigarette alternative products among adults who smoke menthol cigarettes. Findings underscore the importance of comprehensive menthol cigarette restrictions that cover accessories and non-menthol cooling cigarettes to maximize public health.

2025-12-01·FOOD CHEMISTRY

In-situ hydrogen bonding driven green extraction of five Sudan dyes from tomato ketchup using thymol followed by UHPLC-PDA analysis

Article

作者: Sagar, Garima ; Pandey, Ajay Kumar ; Roy, Somendu Kumar ; Kumar, Alok ; Bano, Sana

We explored the potential of thymol and menthol, which are natural hydrophobic compounds containing hydrogen-bond-donor and -acceptor group, as an extractant and developed an extraction method for the simultaneous determination of five Sudan dyes in tomato ketchup. To maximize extraction efficiency, we optimized key factors that affect the extraction process. The samples were then analysed using UHPLC-PDA. Results showed that thymol provided a higher recovery compared to menthol. ¹H NMR chemical shifts and 2D-NOESY spectral correlation studies confirmed the formation of hydrogen bonds between the Sudan dye and thymol, supporting a hydrogen-bonding-based extraction mechanism. The optimized method demonstrated excellent recovery at three spiked concentrations (0.05, 0.25, and 1.25 mg/kg), ranging from 81 to 108 %, with intra- and inter-day variability below 10 %. The greenness of the method, evaluated using the AGREE tool, resulted in a score of 0.62. This study thus presents a greener, reliable and cost-effective method for analysing Sudan dyes in foodstuffs.

项与薄荷脑相关的新闻（医药）

2025-08-29

·华森制药

应对登革热，科学预防，健康生活！

近期，登革热疫情在多地出现，登革热是一种通过蚊媒（主要是白纹伊蚊和埃及伊蚊）传播的病毒性疾病，目前尚无特效药，预防蚊虫叮咬是阻断病毒传播最有效、最经济的关键环节。预防措施主要围绕“防蚊叮咬”和“灭蚊清源”两大核心。一、个人防护：避免蚊虫叮咬 1、穿着防护性衣物：外出时，尽量穿着浅色、宽松、长袖的衣裤。深色衣物更容易吸引蚊虫。 2、使用有效的驱蚊剂：将含有避蚊胺等有效成分的驱蚊剂喷涂在暴露的皮肤和衣物上。 3、改善室内外环境：确保住所（尤其是卧室）安装纱门、纱窗，并保持关闭状态。二、清除蚊虫孳生地：杜绝源头 “清积水”是登革热防控工作的重中之重，因为蚊子在静止的清水中产卵和繁殖。 1、“翻盆倒罐”清积水：每周检查并彻底清理家中及周围环境可能积水的容器，如花盆托盘、水瓶、水桶、废旧轮胎、闲置的瓶罐等。 2、管理功能性积水：用于蓄水的水缸、水箱等容器必须加盖密封。 3、维护环境卫生：保持庭院、阳台清洁，疏通房前屋后的沟渠、下水道，防止堵塞积水。这种病毒的特征伴随着发热、皮疹和剧烈头痛，还有一个令人痛苦的症状——"刀片嗓"。许多患者描述这种咽喉剧痛如同吞咽玻璃碎片，连喝水都变得困难。登革病毒侵入人体后，常会引起全身性炎症反应，咽喉部位作为呼吸道的门户，往往成为重灾区。患者不仅会出现高烧、肌肉酸痛等症状，还会遭遇咽喉红肿、干痛难忍的困扰，医学上称为"病毒性咽炎"。如果有出现以上症状，可以冷敷镇痛：喝冰水、含冰块、吃冰淇淋或凉酸奶。低温可以暂时麻痹喉咙，减轻肿胀和疼痛。温和饮食：选择温凉、流质或半流质的食物，如粥、汤羹、果泥等，避免辛辣、过热、酸性或坚硬的食物刺激喉咙。保持水分：即使吞咽痛苦，也要小口、频繁地喝水或电解质水，防止脱水，这对于降温和管理病情至关重要。增加空气湿度：使用加湿器，或在水龙头打开热水的情况下在浴室里呆一会儿，吸入蒸汽可以湿润喉咙，缓解干燥和疼痛。含服润喉糖或使用喷剂：选择含有薄荷脑、苯佐卡因等轻微麻醉成分的润喉糖或喷雾剂，可以暂时缓解疼痛。最重要的一点，如有不适，请立即就医。对于已经出现的咽干咽痛、失音声哑等咽喉不适，可以使用华森制药甘桔冰梅片，对症用药。

疫苗

2025-07-31

·中国药闻

科普：万能小绿瓶！解锁风油精的隐藏用法

在夏季，很多家庭的药箱中都会有一个熟悉的小绿瓶——风油精。风油精具有清凉、止痛、驱风、止痒的功效，有着特殊的香气，涂抹后能快速带来凉飕飕的舒爽感。在日常生活中，风油精还有很多应用场景。1蚊虫叮咬的“止痒神器”。当蚊子留下“红包印章”时，风油精是有效的“止痒神器”。我们将风油精涂抹在被叮咬处时，风油精中的薄荷脑通过激活TRPM8冷觉受体使人产生清凉错觉，进而可以转移痛觉，缓解瘙痒；桉油可在皮肤表面形成抗菌膜，降低继发感染风险。如果想要止痒效果更好，可以先用肥皂水清洗被叮咬处，再薄涂一层风油精。2伤风感冒的“魔法护盾” 。当病毒对人体发起进攻时，风油精就是“便携药囊”。取适量风油精涂于太阳穴，并配合按揉风池穴，持续15分钟，可有效缓解感冒引起的头痛；用棉签蘸取少许风油精涂于鼻前庭，可促进鼻腔黏膜纤毛摆动，有助于缓解鼻塞。如果感冒后咽喉不适，可以将风油精稀释5倍后漱口，能帮助抑制链球菌；将风油精稀释10倍后用来擦拭大椎穴，有助于儿童高热物理降温。3晕车晕船的“平衡大师” 。当我们晕车晕船时，涂抹风油精有助于缓解头晕带来的不适。风油精中的樟脑具有挥发性，可通过嗅觉通路抑制呕吐中枢；薄荷脑可刺激三叉神经，增强空间方位感。平时容易晕车晕船的人可以在乘坐交通工具前将风油精涂于翳风穴，并配合按摩内关穴，能帮助防止晕车晕船；如果想要效果更好，可以与生姜贴片联用。4跌打损伤的“止痛帮手”。在急性扭伤24小时后涂抹风油精有助于缓解疼痛。这是因为风油精中的丁香酚能够抑制环氧化酶-2活性，减少前列腺素合成；薄荷脑可以促进局部代谢废物排出，加快消肿。但如果皮肤有破损，不要使用风油精，以免引起化学灼伤。需要注意的是，这些操作不可替代专业治疗，且都应在医生指导下进行。使用风油精应严格按照药品说明书或医嘱控制用量，超过药品说明书标注的用量就属于药物过量。儿童或无法自主使用的人群应在他人看护下使用，避免操作不当导致用药过量。同时，要关注药物相互作用，避免将风油精与抗凝药物同时使用，以免增加出血风险。使用风油精后若出现皮疹、皮肤瘙痒等症状，应当立即停止用药。这可能提示皮肤对药物成分过敏，症状严重时应及时就医。另外，风油精并不适用于所有人，孕妇不可使用风油精。因为风油精中的樟脑可能引起子宫收缩，孕妇在孕早期尤其要禁用。哮喘患者慎用风油精，因其可能诱发支气管痉挛。（作者：陈敏湖北省第三人民医院）来源：中国医药报

2025-07-08

·ETPharma

Nectar to sell API, formulations & menthol biz to Ceph Lifesciences for Rs 1,290 cr

New Delhi: Nectar Lifesciences Ltd on Tuesday said it will sell its active pharmaceutical ingredients and formulation along with menthol business assets to Ceph Lifesciences Pvt Ltd, for Rs 1,290 crore. The company has signed a definitive Business Transfer Agreement (BTA) for the sale of its core business division, comprising the manufacture, distribution, and marketing of Active Pharmaceutical Ingredients (APIs) and formulations to Ceph Lifesciences for Rs 1,270 crore on a slump sale basis, Nectar said in a regulatory filing. Additionally, the company has entered into an Asset Purchase Agreement (APA) for the sale of its menthol business assets to Ceph Lifesciences for Rs 20 crore, marking a comprehensive restructuring move aligned with its future strategy, it added. "By divesting mature segments of our business, we are laying the foundation for a focused and agile organisation geared towards innovation and long-term value creation," Nectar Lifesciences Promoter and Chairman Sanjiv Goyal said. Nectar Lifesciences said the transaction forms a part of its long-term strategy to streamline operations, strengthen its financial position, and unlock value for shareholders. "The proceeds from the sale will be used to repay existing debt, invest in new and emerging business areas and reward shareholders, subject to applicable approvals," the company said. Besides, the proceeds will also be used to fund future corporate and growth initiatives, it added. The transaction is expected to be completed on or before September 20, 2025, subject to customary approvals, the filing said, adding there would be no change in the company's existing shareholding.

并购

100 项与薄荷脑相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04918	薄荷脑	R05X	DB14123

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
支气管炎	-	-	-
鼻窦炎	-	-	-

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
咽炎	临床3期	俄罗斯	Sandoz International GmbH	2017-02-22
腺瘤性结肠息肉病	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
去势抵抗性前列腺癌	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
早期胃癌	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
胃腺瘤	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
干眼综合征	临床2期	加拿大	Stearacl Inc	2025-08-17

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03095508 (CTgov)	临床3期	扁桃体炎 \| 扁桃体咽炎 \| 咽炎	229	Angal S, topical spray [Menthol] (Angal S (Arm A))	製餘構齋網膚衊選餘範 = 網鬱膚鹹構繭願網鹽網願膚築艱構獵選餘選製 (鏇繭糧鹹醖築壓獵構獵, 蓋繭築積糧構鑰醖蓋繭 ~ 衊蓋築鹹觸觸獵範醖選) 更多	-	2019-03-21
				ANTI-ANGIN® FORMULA, topical metered spray (ANTI-ANGIN® FORMULA (Arm B))	製餘構齋網膚衊選餘範 = 選鏇鬱壓襯淵築鑰夢築願膚築艱構獵選餘選製 (鏇繭糧鹹醖築壓獵構獵, 鏇廠獵獵壓遞廠選鏇夢 ~ 廠衊醖遞餘鹹願膚壓鏇) 更多
NCT02102100 (CTgov)	N/A	尼古丁依赖	57	nicotine+menthol (Menthol-Preferring Smokers)	觸繭簾簾壓膚繭齋憲餘(蓋顧壓窪顧蓋鬱糧窪鑰) = 構廠餘淵餘艱鏇願淵鹽衊廠鏇鬱壓壓壓窪壓淵 (壓窪鹹醖齋顧齋淵廠選, 0.3803) 更多	-	2019-02-20
				nicotine+menthol (Non-Menthol Preferring Smokers)	觸繭簾簾壓膚繭齋憲餘(蓋顧壓窪顧蓋鬱糧窪鑰) = 夢構膚蓋網製簾衊窪構衊廠鏇鬱壓壓壓窪壓淵 (壓窪鹹醖齋顧齋淵廠選, 0.4292) 更多
JPRN-UMIN000009655 (ASCO2015)	临床2期	化疗引起的损伤	32	Topical menthol	齋淵夢膚壓廠艱選夢蓋(醖淵壓衊繭積顧範獵鑰) = 壓憲顧製網繭鏇膚鹹憲淵鹽構壓鑰願顧鹽構蓋 (網遞齋齋壓壓鬱構製願, 2.7 ~ 32.4)	-	2015-05-20