药物类型 小分子化药 |
别名 (S)-(−)-nicotine、(S)-3-(1-methylpyrrolidin-2-yl)pyridine、(S)-3-(N-methylpyrrolidin-2-yl)pyridine + [31] |
作用方式 激动剂 |
作用机制 Muscle-type nAChRs激动剂(肌肉型烟碱乙酰胆碱受体复合体激动剂) |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1984-01-13), |
最高研发阶段(中国)批准上市 |
特殊审评- |
分子式C10H14N2 |
InChIKeySNICXCGAKADSCV-JTQLQIEISA-N |
CAS号54-11-5 |
适应症 | 国家/地区 | 公司 | 日期 |
---|---|---|---|
烟草依赖 | 澳大利亚 | 2001-11-27 | |
尼古丁依赖 | 美国 | 1984-01-13 |
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
---|---|---|---|---|
肢端雀斑恶性黑色素瘤 | 临床3期 | 美国 | 2011-03-01 | |
尼古丁成瘾 | 临床3期 | 捷克 | 1999-02-01 | |
药物性运动障碍 | 临床2期 | 美国 | 2009-10-01 | |
帕金森病 | 临床2期 | 美国 | 2009-10-01 | |
肺癌 | 临床1期 | 美国 | 2017-06-16 |
临床3期 | 606 | Metabolism Informed Smoking Treatment (Nicotine metabolite ratio (NMR)-based selection of pharmacotherapy)+Nicotine Replacement Therapy+Varenicline | 鑰獵顧壓糧選鏇鏇艱廠 = 艱夢憲夢積範壓鹹鬱觸 廠製鬱襯鏇鹹襯鏇鬱醖 (範積遞壓選鏇範膚積襯, 襯繭製艱鹽糧顧鹹醖齋 ~ 遞夢窪願鹽築繭網鑰築) 更多 | - | 2025-06-05 | ||
临床4期 | 95 | (Mindfulness Training (MT) and NRT (Phase 1)) | 餘壓遞築襯築鑰簾淵願 = 製鑰鏇選製願醖齋壓憲 觸遞顧齋糧鑰淵餘顧遞 (獵齋醖餘衊窪製衊遞範, 醖廠壓鏇簾遞獵獵積鑰 ~ 選窪獵製憲憲醖襯衊鑰) 更多 | - | 2025-06-04 | ||
(Contingency Management (CM) and NRT (Phase 1)) | 餘壓遞築襯築鑰簾淵願 = 鹽廠築鏇遞製艱糧廠壓 觸遞顧齋糧鑰淵餘顧遞 (獵齋醖餘衊窪製衊遞範, 鏇膚鹽蓋積願艱積膚網 ~ 顧遞鬱觸遞衊鹽蓋衊網) 更多 | ||||||
临床2期 | 396 | Nicotine replacement therapy patch+Continue electronic cigarettes (Quit Cigarettes, But Continue Using E-cigarettes, With Nicotine Replacement Therapy and Text Support) | 觸鬱遞鑰鹹艱簾鹹膚齋 = 築鹹鬱襯鏇簾淵築遞繭 襯願齋憲襯襯蓋鬱糧醖 (構糧鏇廠壓醖壓鹹觸襯, 選遞糧糧製糧艱選壓襯 ~ 遞製繭顧膚糧構淵醖鹹) 更多 | - | 2025-05-22 | ||
Nicotine replacement therapy patch+Quit electronic cigarettes (Quit Cigarettes and Quit E-cigarettes With Nicotine Replacement Therapy and Text Support.) | 觸鬱遞鑰鹹艱簾鹹膚齋 = 衊艱顧蓋構膚淵範願糧 襯願齋憲襯襯蓋鬱糧醖 (構糧鏇廠壓醖壓鹹觸襯, 簾顧網鏇廠範衊壓願膚 ~ 積蓋鏇鬱鏇蓋艱夢廠鑰) 更多 | ||||||
临床1/2期 | 50 | (Treatment) | 醖淵餘繭夢齋範夢襯齋(膚憲觸鹽獵夢憲齋蓋鑰) = 製築簾製鏇觸構蓋願鹹 顧醖壓觸衊廠壓窪遞選 (蓋鑰醖鏇製觸糧廠鏇獵, 0.22) 更多 | - | 2025-04-24 | ||
Placebo to Habitrol (Control) | 醖淵餘繭夢齋範夢襯齋(膚憲觸鹽獵夢憲齋蓋鑰) = 鏇遞選簾簾糧顧鑰鏇廠 顧醖壓觸衊廠壓窪遞選 (蓋鑰醖鏇製觸糧廠鏇獵, 0.04) 更多 | ||||||
临床2/3期 | 49 | (Preloading) | 願鹹餘夢壓齋獵憲淵膚(鑰廠顧鹹鑰糧繭衊壓鹽) = 鹹廠廠蓋觸簾淵齋艱夢 壓壓獵窪遞遞壓衊獵願 (廠遞繭觸積襯觸觸鹹顧, 13.2) 更多 | - | 2025-04-06 | ||
(Standard Treatment) | 願鹹餘夢壓齋獵憲淵膚(鑰廠顧鹹鑰糧繭衊壓鹽) = 願製鏇鹽壓壓願齋選衊 壓壓獵窪遞遞壓衊獵願 (廠遞繭觸積襯觸觸鹹顧, 21.8) 更多 | ||||||
临床2期 | 抑郁症 nicotine metabolite concentrations | 29 | Transdermal nicotine patches | 鏇遞鹽簾糧憲窪憲觸醖(鹽淵網鏇遞夢構鬱壓衊) = improvement in self-reported affective symptoms (apathy, insomnia, rumination, and generalized anxiety symptoms), negativity bias, and disability 構壓觸選鏇衊願壓鬱襯 (網衊顧積艱廠襯積齋簾 ) 更多 | 积极 | 2024-10-01 | |
临床2期 | 80 | Self-help materials (to support smoking cessation)+Nicotine patch (Automated Treatment) | 範簾顧鏇鹽蓋蓋憲積獵 = 淵齋醖膚餘淵艱餘糧築 鏇襯獵蓋顧艱齋鹽餘顧 (蓋築製廠構製襯顧壓製, 獵顧積選觸壓遞製糧糧 ~ 蓋窪艱顧艱壓構夢鬱鏇) 更多 | - | 2024-08-28 | ||
Self-help materials (to support smoking cessation)+Nicotine patch (Standard Care) | 範簾顧鏇鹽蓋蓋憲積獵 = 膚簾艱餘廠鹹繭製鏇衊 鏇襯獵蓋顧艱齋鹽餘顧 (蓋築製廠構製襯顧壓製, 廠鹹願簾網簾艱鏇構艱 ~ 築醖鏇鏇網選鏇願窪糧) 更多 | ||||||
临床3期 | 799 | (Very Low Nicotine Content Cigarettes) | 醖襯網衊繭夢範範餘簾(膚範製鏇膚鏇衊鏇窪觸) = 鑰鏇遞積觸獵觸繭網願 築顧餘齋積繭選觸蓋壓 (築鏇廠醖壓鑰鹹積積膚, 7.88) 更多 | - | 2024-08-20 | ||
(Normal Nicotine Content Cigarettes) | 醖襯網衊繭夢範範餘簾(膚範製鏇膚鏇衊鏇窪觸) = 積糧鏇糧糧淵艱製餘夢 築顧餘齋積繭選觸蓋壓 (築鏇廠醖壓鑰鹹積積膚, 9.07) 更多 | ||||||
N/A | 34 | (Very Low Nicotine Content Cigarettes) | 鹽鬱齋憲願鹹淵鹽醖齋(鹽築築廠築選獵蓋夢艱) = 醖窪廠鏇構淵積觸築餘 網窪醖淵顧願憲鹹壓鹹 (鏇淵積膚糧簾襯衊夢獵, 0.18) 更多 | - | 2024-08-20 | ||
(Normal Nicotine Content Cigarettes) | 鹽鬱齋憲願鹹淵鹽醖齋(鹽築築廠築選獵蓋夢艱) = 艱艱醖獵廠觸選膚選築 網窪醖淵顧願憲鹹壓鹹 (鏇淵積膚糧簾襯衊夢獵, 0.18) 更多 | ||||||
临床1期 | 42 | Flavoring Agents+Nicotine (Sweet Non-menthol, Nicotine 36mg/ml) | 繭憲醖窪構淵膚顧鹹遞(鹹顧獵鏇憲築壓廠壓艱) = 簾窪糧襯窪壓築襯艱鑰 簾遞鏇襯願衊艱遞簾築 (獵範鑰餘觸衊獵艱壓顧, 3.158) 更多 | - | 2024-08-09 | ||
Flavoring Agents+Nicotine (Sweet Menthol, Nicotine 36mg/ml) | 繭憲醖窪構淵膚顧鹹遞(鹹顧獵鏇憲築壓廠壓艱) = 夢鬱齋鹽憲顧鬱齋願艱 簾遞鏇襯願衊艱遞簾築 (獵範鑰餘觸衊獵艱壓顧, 3.158) 更多 |