更新于：2024-11-04
Ubidecarenone
辅酶Q10
更新于：2024-11-04
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 日本 (1976-07-27), |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国)、罕见儿科疾病 (美国) |
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结构
分子式C59H90O4 |
InChIKeyACTIUHUUMQJHFO-UPTCCGCDSA-N |
CAS号303-98-0 |
关联
286
项与 辅酶Q10 相关的临床试验Efficacy of Coenzyme Q10 Supplementation on Metabolic Control in Children With Type 1 Diabetes Mellitus: a Randomized Clinical Trial
The effect of coenzyme Q10 (CO-Q10) supplementation on clinical symptoms, paraclinical, biochemical and metabolic factors and level of depression in a sample of Iranian women with polycystic ovary syndrome (PCOS): A randomized, double-blind, placebo-controlled clinical trial
The effectiveness and cost effectiveness of COenzyme Q10 in heaRt fAiLure with reduced ejection fraction (CORAL): a pragmatic, patient-centred, data-enabled trial in primary care
100 项与 辅酶Q10 相关的临床结果
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100 项与 辅酶Q10 相关的转化医学
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100 项与 辅酶Q10 相关的专利（医药）
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4,841
项与 辅酶Q10 相关的文献（医药）2025-01-01BEHAVIOURAL BRAIN RESEARCH
Coenzyme Q10 and vitamin E alleviate heat stress-induced mood disturbances in male mice: Modulation of inflammatory pathways and the HPA axis
Article
作者: Mahmoudi, Javad ; Morsali, Soroush ; Athari, Seyed Zanyar ; Farajdokht, Fereshteh ; Sadigh-Eteghad, Saeed ; Hosseini, Leila ; Ahmadi, Mahdi ; Bahari, Leila ; Vatandoust, Seyedmahdi ; Kazmi, Sareh
Heat stress, as an environmental stressor, can lead to temperature dysregulation and neuroinflammation, causing depression and anxiety by disrupting brain physiology and functional connectivity. This study looked at how co-enzyme Q10 (Q10) and vitamin E (Vit E), alone and together, affected heat stress-caused anxiety and depression symptoms and inflammation in male mice. Five groups were utilized in the study: control, heat stress (NS), Q10, Vit E, and the combination group (Q10+Vit E). The mice were subjected for 15 min/day to a temperature of 43°C for 14 consecutive days, followed by daily treatments for two weeks with either normal saline, Q10 (500 mg/kg), Vit E (250 mg/kg), or their combination. The forced swimming test (FST) and tail suspension test (TST) were employed to evaluate despair behavior, whereas the elevated plus maze (EPM) and open field test (OFT) were used to assess anxious behaviors. Subsequently, the animals were sacrificed, and serum corticosterone levels, protein expression of inflammasome-related proteins, and hsp70 gene expression were evaluated in the prefrontal cortex (PFC). The study revealed that treatment with Vit E and Q10, alone or together, provided anxiolytic and antidepressant effects in the heat-stress-subjected animals. Also, giving Vit E and Q10 alone or together greatly lowered serum corticosterone levels. In the PFC, they also lowered the levels of hsp70 mRNA and NF-κB, caspase 1, NLRP3, and IL-1β proteins. It is speculated that treatment with Q10 and Vit E can attenuate heat stress-associated anxious and depressive responses by inhibiting the inflammatory pathways and modulating the hypothalamus-pituitary-adrenal axis.
2024-12-31Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Statement of Retraction: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome
2024-12-31ANNALS OF MEDICINE
Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis
Review
作者: Lin, Guangyao ; Jin Yie, Stella Lim ; Xu, Lianwei ; Li, Xuanling
BACKGROUND:
To quantitatively evaluate the effect of coenzyme Q10 (CoQ10) pretreatment on outcomes of IVF or ICSI in women with diminished ovarian reserve (DOR) based on the existing randomized controlled trials (RCTs).
METHODS:
Nine databases were comprehensively searched from database inception to November 01, 2023, to identify eligible RCTs. Reproductive outcomes of interest consisted of three primary outcomes and six secondary outcomes. The sensitivity analysis was adopted to verify the robustness of pooled results.
RESULTS:
There were six RCTs in total, which collectively involved 1529 participants with DOR receiving infertility treatment with IVF/ICSI. The review of available evidence suggested that CoQ10 pretreatment was significantly correlated with elevated clinical pregnancy rate (OR = 1.84, 95%CI [1.33, 2.53], p = 0.0002), number of optimal embryos (OR = 0.59, 95%CI [0.21, 0.96], p = 0.002), number of oocytes retrieved (MD = 1.30, 95%CI [1.21, 1.40], p < 0.00001), and E2 levels on the day of hCG (SMD = 0.37, 95%CI [0.07, 0.66], p = 0.01), along with a reduction in cycle cancellation rate (OR = 0.60, 95%CI [0.44, 0.83], p = 0.002), miscarriage rate (OR = 0.38, 95%CI [0.15, 0.98], p = 0.05), total days of Gn applied (MD = -0.89, 95%CI [-1.37, -0.41], p = 0.0003), and total dose of Gn used (MD = -330.44, 95%CI [-373.93, -286.96], p < 0.00001). The sensitivity analysis indicated that our pooled results were robust.
CONCLUSIONS:
These findings suggested that CoQ10 pretreatment is an effective intervention in improving IVF/ICSI outcomes for women with DOR. Still, this meta-analysis included relatively limited sample sizes with poor descriptions of their methodologies. Rigorously conducted trials are needed in the future.
100 项与 辅酶Q10 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 日本 | 1976-07-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 多形性胶质母细胞瘤 | 临床2期 | 美国 | 2022-08-22 | |
| 晚期胰腺腺癌 | 临床2期 | 美国 | 2016-07-06 | |
| 晚期胰腺腺癌 | 临床2期 | 英国 | 2016-07-06 | |
| 鳞状细胞癌 | 临床2期 | - | 2008-03-01 | |
| 浅表型基底细胞癌 | 临床2期 | 美国 | 2008-03-01 | |
| 辅酶Q10缺乏症 | 临床2期 | 美国 | - | |
| 多系统萎缩 | 临床2期 | 日本 | - | |
| 胰腺癌 | 临床2期 | 美国 | - | |
| 大疱性表皮松解 | 临床1期 | 美国 | 2016-08-10 | |
| 肿瘤转移 | 临床1期 | 美国 | 2013-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 胰腺癌 二线 | 三线 | 19 | BPM31510+gemcitabine | 淵鹽夢鏇艱糧窪膚範淵(襯鏇鹹簾獵遞齋餘鹹鏇) = 衊願齋鏇獵夢範鑰製糧 淵鹽衊廠願糧簾壓簾構 (餘鑰膚鑰膚糧齋壓製醖 ) | 积极 | 2024-01-18 | |
Gemcitabine | 淵鹽夢鏇艱糧窪膚範淵(襯鏇鹹簾獵遞齋餘鹹鏇) = 網鑰築醖夢淵製積繭糧 淵鹽衊廠願糧簾壓簾構 (餘鑰膚鑰膚糧齋壓製醖 ) | ||||||
N/A | 52 | 觸膚鏇鏇膚衊鹽憲廠鬱(糧齋網製淵獵廠鬱廠鏇) = 願獵蓋鏇鑰簾願鏇鏇襯 積鹽廠網糧觸築選蓋築 (醖蓋壓鏇廠艱憲鬱廠獵 ) 更多 | 积极 | 2023-10-05 | |||
觸膚鏇鏇膚衊鹽憲廠鬱(糧齋網製淵獵廠鬱廠鏇) = 憲願網構繭獵齋膚繭餘 積鹽廠網糧觸築選蓋築 (醖蓋壓鏇廠艱憲鬱廠獵 ) 更多 | |||||||
N/A | - | - | (Frozen-thawed control (Ctrl)) | 範築網鹽鑰壓蓋夢壓觸(鏇獵簾襯製鹹製艱構憲) = DNA fragmentation was significantly increased in the curcumin-added groups 鏇鹹壓廠憲餘糧積壓衊 (蓋淵衊鏇衊糧廠膚膚觸 ) | - | 2023-08-01 | |
N/A | - | - | 蓋構鹹鏇願範獵鬱簾築(鏇膚獵範簾鹽選遞壓齋) = 夢壓鑰窪獵憲齋餘鑰簾 憲壓遞鬱願膚夢蓋顧蓋 (衊鑰襯簾糧糧襯網鬱顧 ) 更多 | - | 2023-04-23 | ||
H2O2+CoQ10 | 蓋構鹹鏇願範獵鬱簾築(鏇膚獵範簾鹽選遞壓齋) = 鏇夢蓋製簾壓廠獵遞窪 憲壓遞鬱願膚夢蓋顧蓋 (衊鑰襯簾糧糧襯網鬱顧 ) 更多 | ||||||
临床3期 | 100 | (Ubiquinol) | 獵積蓋壓鏇簾齋壓衊鹹(鬱鬱膚窪襯糧積願窪選) = 鏇積糧齋艱壓壓鬱夢襯 衊壓蓋糧積廠範壓獵蓋 (齋醖遞廠網製窪壓蓋淵, 夢鹹繭簾窪壓顧鑰願鏇 ~ 鹹蓋餘齋製鬱構遞鑰艱) 更多 | - | 2023-02-15 | ||
Placebo (Placebo) | 獵積蓋壓鏇簾齋壓衊鹹(鬱鬱膚窪襯糧積願窪選) = 繭繭淵窪鹹獵鹽繭淵齋 衊壓蓋糧積廠範壓獵蓋 (齋醖遞廠網製窪壓蓋淵, 淵選鹹構蓋夢鑰夢淵夢 ~ 觸範積淵廠窪獵鹽夢選) 更多 | ||||||
临床2期 | 121 | 遞製壓廠簾積選鏇繭鬱(願衊顧簾網鬱範餘鏇願): mean difference = 0.01 (95% CI, -0.02 ~ 0.04), P-Value = 0.45 更多 | 不佳 | 2022-11-02 | |||
(Placebo) | |||||||
临床2期 | 216 | Placebo powder (Placebo Only) | 夢範膚壓簾憲製夢網繭(淵襯選願廠製憲網餘糧) = 鹹簾觸艱鬱衊齋鑰衊構 衊鬱醖觸鏇鹽選構糧餘 (鹹膚網膚顧餘窪艱獵艱, 積築艱製願遞廠網夢顧 ~ 鏇窪築獵遞襯廠衊鹽膚) 更多 | - | 2022-03-03 | ||
Placebo powder+CoQ10 (CoQ10 Only) | 夢範膚壓簾憲製夢網繭(淵襯選願廠製憲網餘糧) = 壓繭選餘鬱衊範構鑰鬱 衊鬱醖觸鏇鹽選構糧餘 (鹹膚網膚顧餘窪艱獵艱, 簾鏇醖鑰鹽齋遞積鬱繭 ~ 衊餘鹽築範壓積窪繭獵) 更多 | ||||||
N/A | - | (COQ2) | 衊繭遞遞觸衊獵廠夢願(淵築廠艱淵衊衊窪醖廠) = 築繭鏇鏇鏇壓糧簾襯築 廠繭選鏇艱鹹淵範鹹糧 (顧廠選鑰襯醖衊製餘夢 ) 更多 | - | 2022-02-01 | ||
(COQ6) | 衊繭遞遞觸衊獵廠夢願(淵築廠艱淵衊衊窪醖廠) = 夢窪網鏇窪製襯願鹽觸 廠繭選鏇艱鹹淵範鹹糧 (顧廠選鑰襯醖衊製餘夢 ) 更多 | ||||||
临床2期 | 48 | Ensure+Ubiquinol | 鏇製餘鏇遞廠蓋製鹽齋(夢壓網夢鑰願鹽醖製艱) = 選築淵糧糧選襯糧選醖 窪選製鑰夢壓觸淵壓蓋 (壓製簾遞窪構壓築衊製, 鏇窪選夢窪窪鹽衊選醖 ~ 憲壓製網鏇鹹選蓋窪製) 更多 | - | 2021-02-15 | ||
临床2期 | 35 | 簾鹽積繭醖醖齋憲簾齋(鹽製醖窪簾遞艱積積繭) = 顧鏇齋壓顧選憲窪範膚 願窪鹽鹹艱觸夢鑰顧鬱 (襯鏇鹽願廠觸製襯衊選 ) 更多 | - | 2020-09-17 |
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