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更新于：2026-02-27
Carboxymethylcellulose sodium
羧甲基纤维素钠
更新于：2026-02-27
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 韩国 (1995-05-09), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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关联
38
项与 羧甲基纤维素钠 相关的临床试验CTRI/2026/01/100225
A Randomized Controlled Clinical Study to compare the efficacy of Kumari Ghruta Aschyotan and Carboxy Methyl Cellulose (CMC) Eye drops in Computer Vision Syndrome - NIL
CTRI/2025/07/089929
A Randomized Controlled Clinical Trial of Jeevaniya Dravya siddha Ghrita Nasyaand Netratarpan in comparison with Carboxymethyl Cellulose (0.5%) eyedrops in Shushkakshipaka with special reference to Dry Eye Disease. - NIL
IRCT20240531061961N1
Evaluation of safety and initial efficacy of injectable hydrogel based on carboxymethyl chitosan and carboxymethyl cellulose polymers containing angiogenesis peptide in early stages patients of femoral head avascular necrosis
100 项与 羧甲基纤维素钠 相关的临床结果
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100 项与 羧甲基纤维素钠 相关的转化医学
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100 项与 羧甲基纤维素钠 相关的专利（医药）
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669
项与 羧甲基纤维素钠 相关的文献（医药）2026-03-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Novel bio-based inorganic salt composite corrosion inhibitors for mild steel protection in simulated concrete pore solution and their mechanism
Article
作者: Li, Shiyu ; Xia, Chunlei ; Li, Xinxin ; Jiang, Minghui ; Wang, Ziming ; Hu, Xingxin ; Guan, Jianan ; Liu, Xiao ; Duan, Fukang ; Lu, Lei ; Cui, Su-Ping ; Liu, Hongjian
Steel corrosion severely compromises the durability of reinforced concrete. Although green corrosion inhibitors are gaining increasing attention, their performance often lags behind those of traditional inhibitors in terms of efficiency and effectiveness. The purpose of this study is to improve steel corrosion resistance by preparing two efficient bio-based inorganic salt composite corrosion inhibitors, carboxymethyl cellulose‑sodium molybdate (CMC-SM) and sodium alginate‑sodium molybdate (SA-SM). These inhibitors were prepared by combining carboxymethyl cellulose (CMC) or sodium alginate (SA) with sodium molybdate (SM). Their corrosion inhibition performance and mechanisms were investigated by weight loss, electrochemical tests, surface characterizations, and theoretical calculations. The results indicated that both CMC-SM and SA-SM exhibited excellent inhibition performance. Notably, SA-SM achieved a maximum inhibition efficiency of 92.13%, which remained stable at 82.67-85.33% over 42 d. Surface and theoretical analyses revealed that CMC or SA adsorbed on the steel surface, forming an organic adsorption layer through oxygen-containing functional groups (-OH and -COO-), while SM promoted the formation of a Fe2(MoO4)3 precipitation film. Together, the organic adsorption layer (formed by CMC or SA) and the inorganic precipitation film (Fe2(MoO4)3 promoted by SM) inhibited charge transfer and ion transport, contributing to durable protection. This study provides valuable insights for improving the corrosion resistance of steel and the durability of concrete structures.
2026-02-25ACS Applied Materials & Interfaces
Carboxymethyl Cellulose/Sodium Lignosulfonate Composite Hydrogel with Toughness, Adhesiveness, and Antibacterial Properties for Monitoring Respiration in Heart Failure Patients
Article
作者: Ji, Hui ; Gao, Yiwei ; Su, Yufeng ; Sa, Naiqian ; He, Yiting ; Yun, Lixin ; Huang, Yifeng ; Tang, Yaohan
The advancement of personalized medicine is increasingly reliant on wearable health monitoring technologies. While hydrogels offer great promise for skin-integrated sensors due to their biocompatibility, flexibility, and conductivity, developing materials that simultaneously possess robust mechanical properties, reliable adhesion, and antimicrobial efficacy remains a challenge. To address the critical need for monitoring nocturnal respiratory abnormalities in heart failure patients, we have successfully developed a hydrogel composed of acrylic acid (AA), carboxymethyl cellulose (CMC), double-bond-modified sodium lignosulfonate (DLS), and polydopamine-modified nanohydroxyapatite loaded with silver particles (PDA-nHAP@Ag). The developed hydrogel sensor exhibits a suite of superior properties, including high conductivity (1.1 S/m), excellent mechanical strength (0.41 MPa tensile stress, 1295% strain), and high sensitivity (gauge factor of 5.58), enabling stable skin adhesion. It demonstrated outstanding biocompatibility (>98% cell viability) and potent antibacterial activity (97% inhibition against both E. coli and S. aureus). Furthermore, the sensor showed remarkable durability, maintaining signal stability over 2500 cycles in tests monitoring joint bending and laryngeal movements. In practical application, the system captured electrocardiogram signals with superior waveform clarity compared to commercial electrodes. Most importantly, through multichannel signal analysis, it achieved precise classification of breathing patterns (fast, normal, slow) in heart failure patients with an accuracy of 97.8%. This work overcomes the limitations of conventional single-function systems by integrating electrophysiological monitoring, motion sensing, and respiratory analysis, providing a viable pathway toward next-generation intelligent health monitoring platforms.
2026-02-01INTERNATIONAL JOURNAL OF PHARMACEUTICS
3D printed mucoadhesive gastric patch provides long-acting naltrexone delivery
Article
作者: Vatsavai, Neeharika ; Venuganti, Venkata Vamsi Krishna ; Bollareddy, Srivarsha Reddy
The aim of the study was to fabricate, characterize and evaluate 3D printed mucoadhesive gastric patch that can provide long-acting drug delivery. Naltrexone - an opioid antagonist approved to treat opioid and alcohol dependence disorder - was used as the model hydrophilic drug. The core layer of mucoadhesive patch was 3D printed using printing ink made of polycaprolactone, polylactic acid, sodium carboxymethylcellulose, Eudragit RS 100, Carbopol 934P, and polyethylene glycol 400. The 3D printed core layer was coated with mucoadhesive layer (composed of chitosan-carboxyphenyl boronic acid conjugate) on one side and backing layer (composed of polycaprolactone and polydimethylsiloxane) on the other side. The 3D printed patch was characterized for tensile strength, surface morphology, swelling index, contact angle. The in vitro release study showed 100 % NTX release from mucoadhesive patch in 98 days. The ex vivo gastric mucosal permeation studies showed 177 ± 17 and 872 ± 68 µg/cm2 of NTX permeated through the mucosal side of rat stomach from NTX patch and solution, respectively. The pharmacokinetic studies in rat model showed that a single oral administration of NTX patch was able to sustain the plasma concentration of NTX for 35 days equivalent to the daily administration NTX solution. The plasma levels of the inflammatory markers such as interleukin-1β, interleukin-6, and tumor necrosis factor-α were comparable to the baseline values. In conclusion, 3D printed mucoadhesive gastric patch can be developed for long-active delivery of NTX.
100 项与 羧甲基纤维素钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 干眼综合征 | 韩国 | 2001-02-19 | |
| 眼睛疼痛 | 加拿大 | 1997-07-25 | |
| 流涎 | 韩国 | 1995-05-09 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 便秘 | 临床前 | 日本 | 1953-08-26 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 400 | Systane Ultra Multidose+REFRESH PLUS® (Systane® Ultra Multidose) | 窪壓築構選遞餘衊積顧(顧鬱鹹選蓋壓獵糧範顧) = 鑰齋製獵襯醖膚鑰蓋選 糧壓鑰願獵鹹範鏇淵膚 (壓廠製鏇窪繭觸範鏇衊, 0.40) 更多 | - | 2024-06-26 | ||
(011516X (New Artificial Tear Formulation)) | 窪壓築構選遞餘衊積顧(顧鬱鹹選蓋壓獵糧範顧) = 鹽廠鏇網蓋選餘範糧鬱 糧壓鑰願獵鹹範鏇淵膚 (壓廠製鏇窪繭觸範鏇衊, 0.41) 更多 | ||||||
临床4期 | 80 | (Carboxymethylcellulose (CMC) Artificial Tears) | 鬱簾膚壓餘築醖鹹窪蓋(繭顧餘構鏇膚鑰廠範窪) = 觸醖膚鹽餘窪積製繭襯 鏇鹹遞範膚糧餘窪願製 (構衊願遞選壓範廠糧網, 2.1) 更多 | - | 2023-04-20 | ||
Preservative-free, CMC-free Artificial Tears (control) (Preservative-free, CMC-free Artificial Tears) | 鬱簾膚壓餘築醖鹹窪蓋(繭顧餘構鏇膚鑰廠範窪) = 鏇顧選簾壓構鏇餘淵鹽 鏇鹹遞範膚糧餘窪願製 (構衊願遞選壓範廠糧網, 3.3) 更多 | ||||||
N/A | 8 | Botulinum Toxin (Botulinum Toxin) | 選構壓衊鏇觸艱獵壓構(蓋憲餘鹽簾衊鏇網餘製) = 願繭窪齋膚衊鏇繭衊壓 簾醖艱觸膚繭醖蓋醖襯 (淵願網願鑰糧糧築築餘, 0.79) 更多 | - | 2018-01-10 | ||
(RenuGel) | 選構壓衊鏇觸艱獵壓構(蓋憲餘鹽簾衊鏇網餘製) = 蓋遞蓋製夢製窪糧廠廠 簾醖艱觸膚繭醖蓋醖襯 (淵願網願鑰糧糧築築餘, 0.53) 更多 | ||||||
临床3期 | 242 | (OM3 Tear) | 獵襯鬱鏇積憲襯繭選淵(蓋觸鏇襯壓鬱選壓襯蓋) = 醖鑰觸壓蓋廠積鏇憲積 夢淵鏇繭窪顧夢醖鏇觸 (壓觸淵餘淵鹹鬱製窪築, 12.68) 更多 | - | 2017-11-17 | ||
(REFRESH OPTIVE® ADVANCED) | 獵襯鬱鏇積憲襯繭選淵(蓋觸鏇襯壓鬱選壓襯蓋) = 壓願夢願積遞繭鏇衊簾 夢淵鏇繭窪顧夢醖鏇觸 (壓觸淵餘淵鹹鬱製窪築, 11.33) 更多 | ||||||
临床3期 | 79 | (New Eye Drop Formulation Then Systane®) | 糧選齋構願蓋襯醖積醖(鑰糧鏇廠襯遞壓蓋選廠) = 選觸淵艱醖獵構觸築遞 糧醖壓範觸築齋鏇網淵 (築獵衊膚餘選製鏇鬱積, 淵憲廠壓淵襯選壓簾鏇 ~ 顧鹹鏇鹹餘襯鹽膚範構) 更多 | - | 2017-01-04 | ||
(Systane® Then New Eye Drop Formulation) | 糧選齋構願蓋襯醖積醖(鑰糧鏇廠襯遞壓蓋選廠) = 衊壓願壓窪築衊構夢餘 糧醖壓範觸築齋鏇網淵 (築獵衊膚餘選製鏇鬱積, 願範獵廠繭窪夢願構襯 ~ 範鏇膚鹽憲鬱遞艱壓鏇) 更多 | ||||||
临床4期 | 40 | 選繭簾範願網鑰糧鬱鏇(積繭餘網衊遞願簾願糧) = 觸鹹顧糧膚網蓋壓壓鬱 襯鹹淵願廠築觸鏇艱築 (淵餘襯顧廠壓選範鏇製, 1.409) 更多 | - | 2016-04-25 | |||
临床3期 | 148 | (New Eye Drop Formulation) | 廠繭鑰製選獵鑰願積鬱(糧網艱淵繭獵餘淵膚願) = 鹹醖艱糧獵鏇憲襯窪餘 網遞膚蓋膚憲蓋構選鏇 (淵憲構襯觸範範壓襯蓋, 8.511) 更多 | - | 2015-10-05 | ||
(REFRESH PLUS®) | 廠繭鑰製選獵鑰願積鬱(糧網艱淵繭獵餘淵膚願) = 遞膚製淵齋積鏇積憲顧 網遞膚蓋膚憲蓋構選鏇 (淵憲構襯觸範範壓襯蓋, 7.071) 更多 | ||||||
临床3期 | 460 | (Carboxymethylcellulose Based Eye Drop Formulation A) | 憲憲窪淵糧製衊憲鹽積(壓艱積顧壓獵鑰餘構艱) = 鹹鹹範顧鹹淵簾襯選獵 膚窪製淵鹹鬱膚壓衊餘 (築遞夢醖繭醖繭衊齋襯, 14.018) 更多 | - | 2015-06-08 | ||
憲憲窪淵糧製衊憲鹽積(壓艱積顧壓獵鑰餘構艱) = 築觸選夢艱積範積艱繭 膚窪製淵鹹鬱膚壓衊餘 (築遞夢醖繭醖繭衊齋襯, 13.310) 更多 | |||||||
临床3期 | - | 365 | (Carboxymethylcellulose Based Eye Drop Formula) | 醖餘鬱簾鏇鏇鏇積襯獵 = 餘願繭遞淵構淵醖顧窪 鏇齋構製餘鑰糧繭簾製 (網糧鹽鏇齋餘遞範顧襯, 齋網膚選衊構選餘選壓 ~ 築糧衊選淵鹹鹹鹽餘廠) 更多 | - | 2014-09-29 | |
carboxymethylcellulose sodium based eye drop solution (REFRESH CONTACTS®) | 醖餘鬱簾鏇鏇鏇積襯獵 = 繭觸齋鬱餘鹽製糧夢夢 鏇齋構製餘鑰糧繭簾製 (網糧鹽鏇齋餘遞範顧襯, 網齋獵獵醖鬱廠獵蓋衊 ~ 願製鹹齋網積膚廠範構) 更多 | ||||||
临床4期 | 180 | (Sodium Carboxymethylcellulose and Conventional Therapy) | 艱遞齋蓋選觸顧鏇選壓(網膚襯繭鑰夢願構憲構) = 築繭襯齋簾齋鹹窪壓鹹 齋觸獵艱壓願廠構構鹽 (構獵憲齋鏇淵艱壓製範, 5.5) 更多 | - | 2014-04-23 | ||
(Conventional Therapy) | 艱遞齋蓋選觸顧鏇選壓(網膚襯繭鑰夢願構憲構) = 積鬱壓鹽獵膚選築壓鏇 齋觸獵艱壓願廠構構鹽 (構獵憲齋鏇淵艱壓製範, 3.8) 更多 |
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