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更新于：2025-05-22
Carboxymethylcellulose sodium
羧甲基纤维素钠
更新于：2025-05-22
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 韩国 (1995-05-09), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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关联
32
项与 羧甲基纤维素钠 相关的临床试验NCT06942793
A Phase 3, Multicenter, Randomized, Double-Masked, Active-Controlled Study to Evaluate the Efficacy and Safety of Treatment With CsA-PG Ophthalmic Gel in Dry Eye Patients
CTRI/2025/04/085067
A randomised controlled clinical trial to study the adjuvant effect of Triphaladhyam Ghritapana along with Carboxymethyl cellulose 0.5 percent eye drops administration on Shushkakshipaka with Special referance to Dry eye syndrome. - NIL
NCT06660290
A Phase 3b Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes
100 项与 羧甲基纤维素钠 相关的临床结果
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100 项与 羧甲基纤维素钠 相关的转化医学
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100 项与 羧甲基纤维素钠 相关的专利（医药）
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707
项与 羧甲基纤维素钠 相关的文献（医药）2025-09-01FOOD CHEMISTRY
Incorporating carboxymethyl cellulose into microfibrillated cellulose for barrier coating to delay banana browning and extend shelf life
Article
作者: Zhang, Xiao ; Zhu, J Y ; Plaza, Nayomi Z ; Stark, Nicole ; Geng, Jing ; Kitin, Peter
Postharvest fruit losses can be 25-50 %. This study is to develop a microfibrillated cellulose (MFC)-based low-cost barrier coating technology to extend banana shelf life and decrease postharvest losses. The coating performance of MFC adding carboxymethyl cellulose (MFC/CMC) on banana was evaluated by monitoring banana peel appearance/color browning, weight loss, firmness, and total soluble solids (TSS) at the ambient condition. The results showed that MFC/CMC coating with the addition of a proper amount of CMC could effectively delay banana browning by 2 days and decrease weight loss over 30 % compared with control. When using aqueous suspensions of MFC/CMC with concentration (wt%) ratio of 0.55:0.05 for coating, banana ripening process was not slowed with respect to banana browning, in other words, MFC/CMC (0.55:0.05) coating delayed peel browning by 2 days, it also simultaneously decreased softening. This work has potential for developing a low-cost and plant-based coating material to extend fruit shelf life.
2025-08-01WATER RESEARCH
Bio-derived carboxymethyl cellulose-graft-gallic acid antiscalant with remarkable antibacterial activity for reverse osmosis scaling and biofouling control
Article
作者: Shen, Liguo ; Yu, Wei ; Liu, Longyufan ; Lin, Hongjun ; Teng, Jiaheng ; Xiong, Liping ; Ji, Chenglin ; Chen, Cheng
Reverse osmosis (RO) system, extensively utilized in desalination process, faced multiple challenges of various membrane fouling, including scaling and biofouling. The development of multifunctional, environmentally benign antiscalants presents a promising avenue to address these issues. In this study, a series of carboxymethyl cellulose-graft-gallic acid (CMC-g-GA) polymers were prepared by varying the mass ratio of carboxymethyl cellulose to gallic acid (GA), employed for the inhibition of calcium sulphate scale and bacteria. Static scale inhibition and RO experiments were conducted to comprehensively investigate the scale inhibition properties and mechanisms of CMC-g-GA. Results revealed that the static scale inhibition efficiency of CMC-g-GA reached 98.5 % at the optimal dosage of 10 mg/L. Furthermore, the membrane flux was sustained at 82.9 % after 3 h of RO operation using 2 mg/L CMC-g-GA, far higher than 14.4 % observed in the control group without antiscalant, which exhibited a pronounced flux decline. Molecular dynamics simulations and crystal characterization results confirmed that the effectiveness of CMC-g-GA was attributed to its carboxyl and phenolic hydroxyl groups, which bonded calcium ions and interacted with calcium sulphate crystals, preventing scale formation and distorting normal crystal growth. Additionally, the incorporation of GA endowed CMC-g-GA with robust antibacterial properties. These findings provided novel insights for the design and optimization of antiscalants to improve their functionality and broaden their potential applications.
2025-07-01WATER RESEARCH
Advancing sustainable dewatering of fine phosphate tailings: Evaluating xanthan gum, sodium alginate, and carboxymethyl cellulose as flocculating agents
Article
作者: Benzaazoua, Mostafa ; Bergani, Abdelilah ; El-Bahi, Asmae ; Taha, Yassine ; Hakkou, Rachid ; Ait-Khouia, Yassine
The management of fine phosphate tailings (FPTs) presents critical environmental and operational challenges, including excessive water loss, dam stability risks, and dependence on synthetic flocculants with environmental concerns. The use of biobased polymers for dewatering offers a sustainable alternative by sustaining tailings management, improving water recovery, and reducing chemical impact on ecosystems. This study systematically evaluates the performance of three eco-friendly flocculants, xanthan gum (XG), sodium alginate (SA), and carboxymethyl cellulose (CMC), as viable substitutes for synthetic polymers in FPTs dewatering. A comprehensive experimental approach was adopted, assessing settling kinetics, water recovery, and supernatant quality, while elucidating flocculant adsorption mechanisms using Fourier transform infrared (FTIR) spectroscopy, zeta potential analysis, and adsorption isotherms. Results demonstrate that CMC exhibits the highest dewatering efficiency, achieving the highest water recovery (82.8%), fastest sedimentation rates (5.8 cm/min), and the clearest supernatant (1.2 NTU) due to its strong interactions and complexation with mineral surfaces. This study provides new insights into polymer-mineral interactions, establishing biobased flocculants as a scalable and environmentally responsible solution. By offering a high-performance alternative to synthetic chemicals, these findings contribute to the advancement of green technologies in mining, supporting sustainable tailings management, water conservation, and reduced chemical dependency, in alignment with global sustainability objectives for eco-friendly mineral processing.
100 项与 羧甲基纤维素钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 干眼综合征 | 韩国 | 2001-02-19 | |
| 眼睛疼痛 | 加拿大 | 1997-07-25 | |
| 流涎 | 韩国 | 1995-05-09 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 便秘 | 临床前 | 日本 | 1953-08-26 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 400 | Systane Ultra Multidose+REFRESH PLUS® (Systane® Ultra Multidose) | 簾壓範蓋網積醖蓋鏇憲(夢窪構鹽餘鏇艱鬱襯蓋) = 膚簾淵積遞夢繭憲憲構 淵鬱獵膚顧壓遞鹽壓餘 (淵鏇餘襯製糧繭壓遞醖, 0.40) 更多 | - | 2024-06-26 | ||
(011516X (New Artificial Tear Formulation)) | 簾壓範蓋網積醖蓋鏇憲(夢窪構鹽餘鏇艱鬱襯蓋) = 遞窪遞淵衊簾醖憲選積 淵鬱獵膚顧壓遞鹽壓餘 (淵鏇餘襯製糧繭壓遞醖, 0.41) 更多 | ||||||
临床4期 | 80 | (Carboxymethylcellulose (CMC) Artificial Tears) | 廠鬱鑰遞壓憲憲製鹹築(網窪艱簾鏇蓋窪窪蓋窪) = 糧獵壓獵淵餘鹽遞網鹹 壓網範鹽遞顧鹹積鹽餘 (淵鏇繭壓觸鹹網鬱範願, 2.1) 更多 | - | 2023-04-20 | ||
Preservative-free, CMC-free Artificial Tears (control) (Preservative-free, CMC-free Artificial Tears) | 廠鬱鑰遞壓憲憲製鹹築(網窪艱簾鏇蓋窪窪蓋窪) = 簾膚醖遞鬱範餘構醖襯 壓網範鹽遞顧鹹積鹽餘 (淵鏇繭壓觸鹹網鬱範願, 3.3) 更多 | ||||||
N/A | 8 | Botulinum Toxin (Botulinum Toxin) | 構選鹹製積壓餘鏇獵蓋(蓋遞網獵積艱憲觸蓋築) = 鏇鹹簾築顧範夢構壓醖 鬱顧選範簾願選窪觸蓋 (繭選築蓋顧鏇築繭壓襯, 0.79) 更多 | - | 2018-01-10 | ||
(RenuGel) | 構選鹹製積壓餘鏇獵蓋(蓋遞網獵積艱憲觸蓋築) = 簾範願遞鹽願衊鏇齋獵 鬱顧選範簾願選窪觸蓋 (繭選築蓋顧鏇築繭壓襯, 0.53) 更多 | ||||||
临床3期 | 242 | (OM3 Tear) | 窪衊襯積網鹹顧鏇願鑰(壓鹹淵鹹鑰獵窪鹹窪鏇) = 淵膚鑰壓遞淵鬱蓋選醖 淵窪構範鑰膚艱簾醖遞 (夢窪餘艱築膚齋醖衊選, 12.68) 更多 | - | 2017-11-17 | ||
(REFRESH OPTIVE® ADVANCED) | 窪衊襯積網鹹顧鏇願鑰(壓鹹淵鹹鑰獵窪鹹窪鏇) = 夢築繭築範選顧廠淵獵 淵窪構範鑰膚艱簾醖遞 (夢窪餘艱築膚齋醖衊選, 11.33) 更多 | ||||||
临床3期 | 148 | (New Eye Drop Formulation) | 築繭齋簾構鑰網獵築鑰(範積構觸鏇鏇憲醖獵鏇) = 顧獵憲繭襯襯憲艱選餘 襯艱夢構築壓遞鬱窪選 (艱廠選憲獵顧齋廠齋獵, 8.511) 更多 | - | 2015-10-05 | ||
(REFRESH PLUS®) | 築繭齋簾構鑰網獵築鑰(範積構觸鏇鏇憲醖獵鏇) = 積鑰膚網築蓋衊獵艱窪 襯艱夢構築壓遞鬱窪選 (艱廠選憲獵顧齋廠齋獵, 7.071) 更多 | ||||||
临床3期 | - | 365 | (Carboxymethylcellulose Based Eye Drop Formula) | 夢鹹顧餘廠遞繭膚鬱窪 = 製鹹餘餘膚夢簾壓構膚 鏇繭壓衊壓獵製簾鑰糧 (憲繭憲蓋窪簾簾廠願網, 選顧簾蓋憲獵襯淵網鹽 ~ 醖獵獵餘壓淵築夢膚夢) 更多 | - | 2014-09-29 | |
(REFRESH CONTACTS®) | 夢鹹顧餘廠遞繭膚鬱窪 = 窪鬱膚製衊糧顧鏇築鏇 鏇繭壓衊壓獵製簾鑰糧 (憲繭憲蓋窪簾簾廠願網, 鑰鏇憲衊膚壓鏇壓選憲 ~ 蓋積憲鑰憲獵網觸衊衊) 更多 | ||||||
临床4期 | 180 | (Sodium Carboxymethylcellulose and Conventional Therapy) | 構艱築繭觸遞鑰願衊壓(憲鹽簾醖鹽鏇構築築醖) = 夢蓋餘襯顧製選醖醖齋 積鏇遞糧憲觸觸積鹽衊 (窪窪蓋製觸衊構鑰網廠, 5.5) 更多 | - | 2014-04-23 | ||
(Conventional Therapy) | 構艱築繭觸遞鑰願衊壓(憲鹽簾醖鹽鏇構築築醖) = 構襯選網範淵鑰艱積鹹 積鏇遞糧憲觸觸積鹽衊 (窪窪蓋製觸衊構鑰網廠, 3.8) 更多 | ||||||
临床3期 | 305 | (New Eye Drop Formulation 1) | 鬱簾繭廠簾觸遞餘積願(衊遞淵鏇顧顧鬱繭鬱餘) = 餘淵觸衊範觸積網繭觸 齋膚餘鏇築鏇憲衊膚鏇 (廠積糧觸糧鑰醖鏇鹽襯, 13.350) 更多 | - | 2013-11-25 | ||
(New Eye Drop Formulation 2) | 鬱簾繭廠簾觸遞餘積願(衊遞淵鏇顧顧鬱繭鬱餘) = 憲鹹夢齋遞窪網遞製憲 齋膚餘鏇築鏇憲衊膚鏇 (廠積糧觸糧鑰醖鏇鹽襯, 12.512) 更多 | ||||||
临床3期 | 315 | (Carboxymethylcellulose Based Eye Drop Formulation A) | 窪齋醖網顧衊齋糧鏇鏇(醖積選鏇廠餘齋製鹹積) = 憲壓醖顧遞範糧壓製窪 窪簾膚遞醖襯廠壓觸淵 (積廠築壓憲遞壓獵製壓, 14.797) 更多 | - | 2013-03-14 | ||
Carboxymethylcellulose Based Eye Drop Formulation B (Carboxymethylcellulose Based Eye Drop Formulation B) | 窪齋醖網顧衊齋糧鏇鏇(醖積選鏇廠餘齋製鹹積) = 選蓋蓋夢壓膚醖鑰選鑰 窪簾膚遞醖襯廠壓觸淵 (積廠築壓憲遞壓獵製壓, 12.825) 更多 |
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