预约演示
更新于：2025-07-01
Erythromycin Ethylsuccinate
琥乙红霉素
更新于：2025-07-01
概要
基本信息
药物类型 小分子化药 |
别名 Eryth romycin Ethylsuccinate、Erythromcin Ethylsuccinate、Erythromycin Ethy.lsuccinate + [22] |
作用方式 抑制剂 |
作用机制 50S subunit抑制剂(50S核糖体亚基抑制剂) |
在研适应症 |
非在研适应症- |
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1965-04-02), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C43H75NO16 |
InChIKeyNSYZCCDSJNWWJL-YXOIYICCSA-N |
CAS号1264-62-6 |
关联
14
项与 琥乙红霉素 相关的临床试验CTR20250980
中国健康受试者空腹状态下单次口服琥乙红霉素片的单中心、开放、随机、两制剂、两序列、四周期、完全重复交叉人体生物等效性试验
CTR20234193
琥乙红霉素片在健康受试者中随机、开放、单剂量、两制剂、两序列、交叉对照空腹及餐后状态下的生物等效性研究
CTR20234164
琥乙红霉素片在健康受试者中随机、开放、单剂量、两制剂、单次给药、交叉对照空腹及餐后状态下的生物等效性研究
100 项与 琥乙红霉素 相关的临床结果
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100 项与 琥乙红霉素 相关的转化医学
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100 项与 琥乙红霉素 相关的专利（医药）
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518
项与 琥乙红霉素 相关的文献（医药）2025-02-01CHEST
Characteristic Pulmonary Impedance With Exercise Detects Abnormal Pulmonary Vascular Response and Uncoupling in Pulmonary Hypertension Resulting From Heart Failure With Preserved Ejection Fraction
Article
作者: Eickhoff, Jens C ; Korcarz, Claudia E ; Broman, Aimee T ; Raza, Farhan ; Chesler, Naomi C ; Colebank, Mitchel J ; Lechuga, Christopher G
BACKGROUND:
Pulmonary hypertension (PH) resulting from heart failure with preserved ejection fraction (PH-HFpEF) can lead to right ventricular-pulmonary arterial (RV-PA) uncoupling despite normal steady hemodynamics (eg, pulmonary vascular resistance). Unsteady hemodynamics, quantified by characteristic pulmonary impedance (ZC), may be useful in differentiating those patients with PH-HFpEF who have sufficient coupling from those who have insufficient coupling. We hypothesized that abnormal pulsatile hemodynamics with exercise, quantified by ZC, could precisely detect abnormal cardiopulmonary function in PH-HFpEF.
RESEARCH QUESTION:
Can ZC with exercise detect abnormal pulmonary vascular response and RV-PA uncoupling in PH-HFpEF?
STUDY DESIGN AND METHODS:
Our approach was pilot tested in a small cohort of patients with PH-HFpEF (n = 8), precapillary PH (n = 5), and no PH (n = 2) who underwent rest-exercise (every 25 W)-recovery testing with repeated measurements of characteristic impedance (ZC, from invasive cardiopulmonary exercise and echocardiography for pulmonary vascular pressure-flow) and coupling (end systolic elastance [Ees] to effective arterial elastance [Ea] ratio, from RV pressure-volume loops). Analysis included disease-specific autoregressive correlation structure of order 1 (for repeated measures in time-series analysis).
RESULTS:
Metrics of steady pulmonary hemodynamics with exercise changed in a similar fashion in the 2 disease groups. In contrast, at rest in PH-HFpEF (vs precapillary PH), ZC was low (0.22 [0.14] mm Hg/L/min vs 0.70 [0.20] mm Hg/L/min; P < .0001) and Ees to Ea ratio was high (1.10 [0.36] vs 0.58 [0.22]; P = .0007). During exercise in PH-HFpEF, ZC increased and Ees to Ea ratio decreased, but both remained unchanged in precapillary PH. In PH-HFpEF, a significant negative correlation was found between ZC and Ees to Ea ratio (slope, -0.96; r2 = 0.18; P < .0001) that was absent in precapillary PH (slope, -0.20; r2 = 0.11; P = .53).
INTERPRETATION:
Despite the small sample size, RV-PA uncoupling with exercise was significantly negatively correlated with ZC in PH-HFpEF, which was not evident in precapillary PH, suggesting that abnormal exercise pulsatile hemodynamics are key to RV failure in left-sided heart disease.
2024-11-01TALANTA
A novel photoreduction deposition induced AuNPs/COFs composite for SERS detection of macrolide antibiotics
Article
作者: Xie, Yalin ; Zeng, Yu ; Chen, Liping ; Cui, Kaixin ; Deng, Xiaojun ; Luo, Xiaojun
As we all know, SERS (Surface-enhanced Raman spectroscopy) is widely used in sensing, analysis and detection. The covalent organic frameworks (COFs) have performed well as a material for supporting metal nanoparticles and facilitating analyte adsorption in SERS, which may greatly enhance the detection sensitivity and reproducibility. The synthesis of traditional metal/COFs composites involved chemical reduction methods, however, the resulting metallic NPs exhibited reduced capacity to enhance SERS due to their small particle sizes (usually <20 nm). This paper presented a novel photoreduction method for the facile growth of AuNPs (diameters: 75 nm) on COFs matrix under light control, which represents the first report of such synthesis on COF. Subsequently, the photoreduction deposition induced AuNPs/COFs composites, which served as highly sensitive and reproducible SERS-active substrates for capturing the spectral information of four types of macrolide antibiotics. The detection limits for the four macrolide antibiotics were determined to be 3.30 × 10-11, 3.43 × 10-10, 1.10 × 10-10 and 5.78 × 10-11 M, respectively, exhibiting excellent linear relationships within the concentration range of 10-10 to 10-3 M. Therefore, our proposed SERS method opens up a new idea for the development of SERS substrates and environmental safety monitoring, and it has great potential for ensuring food safety in the future.
2024-08-01JOURNAL OF CLINICAL PHARMACOLOGY
Food Effect in Pediatric Populations: Current Practice, Challenges, and Future Potential for Use of Physiologically Based Biopharmaceutics Modeling
Article
作者: Parrott, Neil
The projection of food effect in children by direct transfer from studies in adults is not optimal.Although clin. data on pediatric food effects are very limited, several cases have shown distinct behavior in children compared to adults and so better methods are needed.Physiol. based biopharmaceutics modeling provides a framework in- tegrating knowledge on age-dependent physiol. and food effect mechanisms and has already shown its value for the projection of food effects in adults and-in a very few examples-in children.Furthermore, important gaps in our knowledge of the ontogeny of the pediatric GI tract need to be filled (Table 2) and improved in vitro dissolution tests for children developed and validated.However, pediatric PBBM should play a key role in advancing the prediction of pediatric doses by integrating growing knowledge on physiol. development with biorelevant in vitro and clin. data.
100 项与 琥乙红霉素 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性支气管炎 | 日本 | 2003-07-04 | |
| 烧伤 | 日本 | 2003-07-04 | |
| 复杂皮肤和皮肤结构感染 | 日本 | 2003-07-04 | |
| 白喉 | 日本 | 2003-07-04 | |
| 脓胸 | 日本 | 2003-07-04 | |
| 淋病 | 日本 | 2003-07-04 | |
| 子宫内感染 | 日本 | 2003-07-04 | |
| 喉炎 | 日本 | 2003-07-04 | |
| 肺脓肿 | 日本 | 2003-07-04 | |
| 淋巴结炎 | 日本 | 2003-07-04 | |
| 淋巴管炎 | 日本 | 2003-07-04 | |
| 乳腺炎 | 日本 | 2003-07-04 | |
| 骨髓炎 | 日本 | 2003-07-04 | |
| 中耳炎 | 日本 | 2003-07-04 | |
| 咽炎 | 日本 | 2003-07-04 | |
| 肺炎 | 日本 | 2003-07-04 | |
| 肾盂肾炎 | 日本 | 2003-07-04 | |
| 慢性呼吸道感染 | 日本 | 2003-07-04 | |
| 猩红热 | 日本 | 2003-07-04 | |
| 继发感染 | 日本 | 2003-07-04 |
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