This is a study to determine if a certain drug, called telotristat ethyl (Xermelo®), can help reduce the chance of blood pressure and heart rate variations (known as carcinoid crisis) in individuals who have neuroendocrine tumors (also called carcinoid tumors). These complications can be life-threatening for patients who already have to experience challenging surgeries to remove their tumors. To determine if telotristat ethyl (Xermelo®) will help reduce these complications during surgery, researchers will give the drug to study participants before surgery.

开始日期2022-01-01

申办/合作机构

The University of Chicago

NCT04543955

/ Terminated临床2期IIT

Study of Telotristat (Xermelo) in Combination With Luetetium Lu177 Dotatate (Lutathera) in Well-Differentiated Neuroendocrine Tumors

This trial will test the hypothesis that Telotristat treatment increases the antitumor efficacy of Lutetium Lu 177 Dotatate therapy in neuroendocrine tumors (NETs).

开始日期2021-09-13

申办/合作机构

University of Kentucky

[+1]

NCT04810091

/ Active, not recruiting临床3期IIT

TELEHEART: Telotristat Ethyl in a Heart Biomarker Study

This phase III trial compares the effect of telotristat ethyl and the current standard of care somatostatin analog therapy or somatostatin analog therapy alone in treating patients with neuroendocrine tumor that has spread to other places in the body (metastatic). Telotristat ethyl and somatostatin analog therapy may help to control carcinoid syndrome and carcinoid heart disease.

开始日期2021-05-18

申办/合作机构

The University of Texas MD Anderson Cancer Center

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2025-01-01·ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Inhaling arsenic aggravates airway hyperreactivity by upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma

Article

作者: Tan, Zhu-Xia ; Wang, Yan ; Lu, Xue ; Li, Zhao ; Li, Ze-Yan ; Peng, Kun ; Yang, Qian-Qun ; Zhu, Yan-Yan ; Xu, De-Xiang ; Yao, Ya-Xin

Increasing epidemiological evidence has proved that early-life exposure to inorganic arsenic (As) elevates the risks of childhood asthma. The present research aimed to explore susceptibility of respiratory As exposure to allergic asthma in a mouse model. BALB/c mice on postnatal day (PND) 28 were exposed to ddH₂O or NaAsO₂ aerosol for 4 hours daily over 5 consecutive weeks via respiratory tract. Mice were sensitized by intraperitoneal injection of ovalbumin (OVA) combined with Alum Adjuvant on PND42 and PND56. Subsequently, mice were challenged with ddH₂O or 1 %OVA through a nebulizer for 3 days starting from PND63. In As-exposed mice, OVA-sensitized goblet cell hyperplasia and airway mucosal secretion did not worsen. OVA-induced inflammatory cell infiltration and upregulation of Th2 cytokines, including IL-4, IL-5, and IL-13, were not aggravated in As-exposed mice. Interestingly, airway hyperreactivity was intensified in As-exposed asthmatic mice. Mechanistically, OVA-induced elevation of 5-hydroxytryptamine (5-HT), probably secreted by pulmonary neuroendocrine cells (PNECs), was exacerbated in As-exposed mice. OVA-induced upregulation of tryptophan hydroxylase (TPH)1 and TPH2, two 5-HT synthases, was aggravated in As-exposed mouse lungs. LX1032, a specific TPH inhibitor, suppressed As-induced elevation of pulmonary 5-HT content in asthmatic mice. Moreover, LX1032 alleviated As-evoked airway hyperreactivity in asthmatic mice. These results suggest that respiratory As exposure elevates airway hyperreactivity partially through upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma, which provides significant insight about the hazards of environmental As exposure.

2024-12-01·Molecular Catalysis

Gene hunting and semi-rational design of carbonyl reductase from Kosakonia radicincitans for highly efficient synthesis of the key chiral intermediate of Telotristat ethyl

作者: Qian, Feng ; Zhang, Hai-Min ; Wang, Yao-Wu ; Wang, Pu ; Liu, Han-Yu ; Ning, Pan

Carbonyl reductase exhibits significant potential in the asym. production of chiral alcs. (αR)-4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)-α-(trifluoromethyl)benzenemethanol ((R)-CMPPFO) is a critical precursor for the synthesis of Telotristat Et, an oral drug for the treatment of diarrhea in carcinoid syndrome.Herein, a novel carbonyl reductase KrSDR5 from Kosakonia radicincitans was obtained using gene hunting strategy, capable of asym. reducing the precursor ketone 1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethanone (CMPPFA) to (R)-CMPPFO with strict R-stereoselectivity (>99.9 % ee).Further, semi-rational design was adopted to acquire a pos. mutant KrSDR5_{T91V/V141M/I159V}, with assistance from a comparative anal. of enzyme-substrate binding mode in mol. dynamics (MD) simulations.This variant displayed a 12.4-fold increase in k_cat/K_m towards CMPPFA compared to the wild-type (WT) KrSDR5.Insights were gained on the high enantioselectivity and the enhancement of enzyme catalytic activity of the mutant through MD simulations.Using the whole-cells of KrSDR5_{T91V/V141M/I159V} as biocatalyst, the asym. synthesis of (R)-CMPPFO was achieved within 20 h at 500 mM CMPPFA concentration, resulting in a 95.0 % yield with >99.9 % ee, and a highest space-time yield (STY) of 165.7 g·L^-1·d^-1 compared with previous reports.This study provides a robust biocatalyst for highly efficient production of the key precursor (R)-CMPPFO for Telotristat Et, highlighting its potential in the biosynthesis of pharmaceutical intermediates.

2024-11-20·ACS Chemical Neuroscience

Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors

Article

作者: Vogelmann, Anja ; Papenkordt, Niklas ; Sippl, Wolfgang ; Bracher, Franz ; Haavik, Jan ; Robaa, Dina ; Jung, Manfred ; Baumann, Anne ; Szigetvari, Peter D.

The aromatic amino acid hydroxylases (AAAHs) phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylases 1 and 2 are structurally related enzymes that contain an active site iron atom and depend on tetrahydrobiopterin (BH₄) as cosubstrate. Due to their important roles in synthesis of serotonin, dopamine, noradrenaline, and adrenaline and their involvement in cardiovascular, neurological, and endocrine disorders, AAAHs have been targeted by substrate analogs, iron chelators, and allosteric ligands. Phenylalanine hydroxylase is also off-target of the histone deacetylase (HDAC) inhibitor panobinostat. To systematically explore the binding of HDAC inhibitors to AAAHs, we screened a library of 307 HDAC inhibitors and structural analogs against tryptophan hydroxylase 1 using a fluorescence-based thermal stability assay, followed by activity assays. Selected hits were enzymatically tested against all four purified human AAAHs. Cellular thermal shift assay was performed for phenylalanine hydroxylase. We show that panobinostat and structurally related compounds such as TB57, which similarly to panobinostat also contains a cinnamoyl hydroxamate, bind to human AAAHs and inhibit these enzymes with high selectivity within the class (panobinostat inhibition (IC₅₀): phenylalanine hydroxylase (18 nM) > tyrosine hydroxylase (450 nM) > tryptophan hydroxylase 1 (1960 nM). This study shows that panobinostat and related hydroxamic acid type HDAC inhibitors inhibit all AAAHs at therapeutically relevant concentrations. Our results warrant further investigations of the off-target relevance of HDAC inhibitors intended for clinical use and provide directions for new dual HDAC/AAAH and selective AAAH inhibitors. These findings may also provide a new mechanistic link between regulation of histone modification, AAAH function, and monoaminergic neurotransmission.

项与特罗司他乙酯相关的新闻（医药）

2022-12-07

·PRNewswire

TerSera® to sponsor "NET Cancer Health Storylines" digital platform to support patients suffering from Carcinoid Syndrome Diarrhea

DEERFIELD, Ill., Dec. 7, 2022 /PRNewswire/ -- TerSera Therapeutics announced today a new sponsorship with the Carcinoid Cancer Foundation (CCF) and Alira Health to expand and optimize a holistic patient journey digital platform for patients with Neuroendocrine Tumors and Carcinoid Syndrome. Carcinoid syndrome (CS) is a rare condition that occurs in patients living with metastatic neuroendocrine tumors (mNETs) and is characterized by frequent and debilitating diarrhea that often prevents patients from leading active, predictable lives. Other symptoms of CS include facial flushing, abdominal pain, fatigue and, over time, for some people, heart valve damage.1-3 To support patients in coping with the impact NETs have on their quality of life and collaborate with their care team on treatment decisions, Alira Health and the Carcinoid Cancer Foundation have collaborated since 2015 to build "NET Cancer Health Storylines," a customized version of the Health Storylines™ app that makes it easy for patients to record their symptoms, nutritional concerns, moods, medication and more. The NET Health Storylines app provides patients with resources developed by NET experts. Specific tools include a Stool Diary, NET Nutrition tool, Medication tracker, and additional educational resources. The app is available for download at the NET Cancer Health Storylines website or through the Apple App Store or Google Play. "We are grateful for this support from TerSera to continue to enhance the NET Health Storylines platform to distribute meaningful educational content to NETs patients. The resources available through this platform are important tools in supporting NET patients throughout their journey," said Keith Warner, Chief Executive Officer of the Carcinoid Cancer Foundation. TerSera Therapeutics is the manufacturer of Xermelo (telotristat ethyl), the only oral medication approved for the treatment of carcinoid syndrome diarrhea (CSD), in combination with somatostatin analog (SSA) therapy.4 "Collaborating with CCF and the NET Cancer Health Storylines platform is a fantastic opportunity for us to support patients with Carcinoid Syndrome Diarrhea beyond our existing clinical nurse educator program. We are also looking forward to learning from patients how we can continue to support them better on their journey," said Pamela Gaytan, Executive Director, Clinical Nurse Educators and Patient Advocacy of TerSera Therapeutics. About Carcinoid Syndrome and Carcinoid Syndrome Diarrhea Carcinoid syndrome (CS) is a rare condition which affects approximately 1 out of every 5 patients with neuroendocrine tumors (NETs).5 In CS, patients have NETs that overproduce certain hormones such as serotonin, bradykinin, and histamine.1 One key hormone that is overproduced in CS is serotonin. Elevated serotonin levels in patients with CS can cause carcinoid syndrome diarrhea (CSD) which is characterized by increased motility in the gastrointestinal (GI) tract and reduced absorption of water and nutrients.2 Patients with CSD can experience multiple, urgent, loose and watery stools several times a day. CSD can have a prominent effect on patients' quality of life. Patients with CSD may avoid social activities and have increased fatigue, anxiety, and weight loss.2,3 About Xermelo Xermelo is the first and only approved oral therapy for CSD.4 Xermelo targets tryptophan hydroxylase, an enzyme that mediates the excess serotonin production within metastatic neuroendocrine tumor (mNET) cells, providing an additional treatment option for patients suffering from CSD. Xermelo is approved in the United States, the European Union, and certain additional countries for the treatment of CSD in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy. Patients and healthcare professionals with questions about Xermelo should call 1-844-334-4035 or visit . IMPORTANT SAFETY INFORMATION ABOUT XERMELO: Indication Xermelo is a tryptophan hydroxylase inhibitor indicated for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy. Contraindications: XERMELO is contraindicated in patients with a history of a hypersensitivity reaction to telotristat. Reactions have included angioedema, rash and pruritis. Warnings and Precautions: XERMELO may cause constipation, which can be serious. Serious complications of constipation have been reported during clinical trials and post marketing with individual reports of intestinal perforation, obstruction, and fecaloma. Monitor for signs and symptoms of constipation and/or severe, persistent, or worsening abdominal pain in patients taking XERMELO. Discontinue XERMELO if severe constipation or severe, persistent, or worsening abdominal pain develops. Adverse Reactions: In a clinical trial of patients with carcinoid syndrome diarrhea and 4-12 bowel movements per day, the most common adverse reactions (≥5%) include nausea, headache, increased gamma-glutamyl transferase, depression, flatulence, decreased appetite, peripheral edema, and pyrexia. In a second clinical trial of patients with carcinoid syndrome diarrhea and less than 4 bowel movements per day, additional adverse reactions of abdominal pain and constipation were reported in ≥5% of patients. Drug Interactions: If necessary, consider increasing the dose of concomitant CYP3A4 and CYP2B6 substrates, as XERMELO may decrease their systemic exposure. If combination treatment with XERMELO and short-acting octreotide is needed, administer short-acting octreotide at least 30 minutes after administering XERMELO. Use in Special Populations: Xermelo is not recommended in patients with moderate and severe hepatic impairment. For more information, please see the full Prescribing Information for Xermelo. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit , or call 1-800-FDA-1088. You can also contact TerSera Therapeutics at 1-844-334-4035 or [email protected]. About TerSera Therapeutics TerSera Therapeutics acquires, develops, and markets specialty pharmaceutical products with a focus on oncology and non-opioid pain. Its mission is to provide products which truly make a difference for patients. For more information about TerSera Therapeutics, please visit . About Carcinoid Cancer Foundation: The Carcinoid Cancer Foundation is the oldest nonprofit carcinoid and neuroendocrine cancer organization in the United States, founded in 1968. The mission of the foundation is to increase awareness and educate the general public and healthcare professionals regarding neuroendocrine tumors (NETs), to support NET cancer patients and their families, and to serve as patient advocates. Visit the CCF website for more information, . About Alira Health Alira Health is a global healthcare firm whose mission is to humanize healthcare and life sciences in partnership with patients. From development to medical care, we complement the expertise of our Pharma, Biotech, and MedTech clients with a full spectrum of services across their entire solutions lifecycle, including clinical operations, real-world evidence, and patient-centric technology offerings. Our integrated and multidisciplinary team of over 600 scientists, strategists, economists, clinicians, and biostatisticians collaborate across our North American, European, and Asian offices and advise 80% of the top 50 MedTech companies and 75% of the top 50 Pharma companies. More information may be obtained at . Media Contacts: References: Clement D, Ramage J, Srirajaskanthan R. Update on Pathophysiology, Treatment, and Complications of Carcinoid Syndrome. J Oncol. 2020 Jan 21;2020:8341426. Naraev BG, Halland M, Halperin DM, et al. Management of Diarrhea in Patients With Carcinoid Syndrome. Pancreas. 2019 Sep;48(8):961-972. Anthony L, Ervin C, Lapuerta P, Kulke MH, Kunz P, Bergsland E, Hörsch D, Metz DC, Pasieka J, Pavlakis N, Pavel M, Caplin M, et al. Understanding the Patient Experience with Carcinoid Syndrome: Exit Interviews from a Randomized, Placebo-controlled Study of Telotristat Ethyl. Clin Ther. 2017 Nov;39(11):2158-2168. XERMELO® (telotristat ethyl) Prescribing Information. TerSera Therapeutics LLC. Halperin DM, Shen C, Dasari A, Xu Y, et al. Frequency of carcinoid syndrome at neuroendocrine tumour diagnosis: a population-based study. Lancet Oncol. 2017 Apr;18(4):525-534. Xermelo® is a registered trademark of TerSera Therapeutics LLC or its affiliates. ©2022 TerSera Therapeutics LLC. All rights reserved. SOURCE TerSera Therapeutics LLC

上市批准

2021-05-06

·GlobeNewswire

Lexicon Pharmaceuticals Reports First Quarter 2021 Financial Results and Provides Clinical Update

Conference Call and Webcast at 5:00 pm Eastern Time THE WOODLANDS, Texas, May 06, 2021 (GLOBE NEWSWIRE) -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), today reported financial results for the three months ended March 31, 2021 and provided an update on key milestones. “We continue to enroll patients in our two proof-of-concept Phase 2 clinical studies for LX9211 in neuropathic pain and look forward to results from these studies by the end of the year,” said Lonnel Coats, Lexicon’s president and chief executive officer. “We are also very pleased with the regulatory feedback received from the FDA on sotagliflozin in heart failure and we are moving expeditiously forward with a planned NDA filing in that indication this year.” First Quarter Highlights LX9211 Sotagliflozin 2021 Anticipated Milestones and Events First Quarter 2021 Financial Highlights Revenues: Revenues for the three months ended March 31, 2021 were negligible as compared to $8.0 million for the corresponding period in 2020, primarily due to the absence of product revenues as a result of the sale of XERMELO during the third quarter of 2020. Research and Development (R&D) Expenses: Research and development expenses for the three months ended March 31, 2021 decreased to $12.6 million from $55.2 million for the corresponding period in 2020, primarily due to decreases in external clinical development costs related to sotagliflozin resulting from the completion of clinical studies. Selling, General and Administrative (SG&A) Expenses: Selling, general and administrative expenses for the three months ended March 31, 2021 decreased to $8.3 million from $14.7 million for the corresponding period in 2020, primarily due to lower salaries and benefit costs as a result of reductions in personnel in September 2020 and lower marketing expenses. Net Loss: Net loss for the three months ended March 31, 2021 was $21.0 million, or $0.15 per share, as compared to a net loss of $66.6 million, or $0.63 per share, in the corresponding period in 2020. For the three months ended March 31, 2021 and 2020, net income included non-cash, stock-based compensation expense of $2.9 million and $4.4 million, respectively. Cash and Investments: As of March 31, 2021, Lexicon had $141.4 million in cash and investments, as compared to $152.3 million as of December 31, 2020. Conference Call and Webcast Information Lexicon management will hold a live conference call and webcast today at 5:00 pm ET / 4:00 pm CT to review its financial and operating results and to provide a general business update. The dial-in number for the conference call is 888-645-5785 (U.S./Canada) or 970-300-1531 (international). The conference ID for all callers is 8456671. The live webcast and replay may be accessed by visiting Lexicon’s website at . An archived version of the webcast will be available on the website for 14 days. About Lexicon Pharmaceuticals Lexicon is a biopharmaceutical company with a mission of pioneering medicines that transform patients’ lives. Through its Genome5000™ program, Lexicon scientists studied the role and function of nearly 5,000 genes and identified more than 100 protein targets with significant therapeutic potential in a range of diseases. Through the precise targeting of these proteins, Lexicon is pioneering the discovery and development of innovative medicines to safely and effectively treat disease. Lexicon advanced one of these medicines to market and has a pipeline of promising drug candidates in discovery and clinical and preclinical development in neuropathic pain, heart failure, diabetes and metabolism and other indications. For additional information, please visit . Safe Harbor Statement This press release contains “forward-looking statements,” including statements relating to Lexicon’s financial position and long-term outlook on its business, including the clinical development of, regulatory filings for, and potential therapeutic and commercial potential of LX9211, sotagliflozin and its other potential drug candidates. In addition, this press release also contains forward looking statements relating to Lexicon’s growth and future operating results, discovery and development of products, strategic alliances and intellectual property, as well as other matters that are not historical facts or information. All forward-looking statements are based on management’s current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including Lexicon’s ability to meet its capital requirements, successfully conduct preclinical and clinical development and obtain necessary regulatory approvals of LX9211, sotagliflozin and its other potential drug candidates on its anticipated timelines, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as additional factors relating to manufacturing, intellectual property rights, and the therapeutic or commercial value of its drug candidates. Any of these risks, uncertainties and other factors may cause Lexicon’s actual results to be materially different from any future results expressed or implied by such forward-looking statements. Information identifying such important factors is contained under “Risk Factors” in Lexicon’s annual report on Form 10-K for the year ended December 31, 2020, as filed with the Securities and Exchange Commission. Lexicon undertakes no obligation to update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise. Lexicon Pharmaceuticals, Inc. Selected Financial Data For Inquiries: Chas SchultzExecutive Director, Corporate Communications and Investor RelationsLexicon Pharmaceuticals(281) 863-3421cschultz@lexpharma.com

财报

2017-01-31

·BioSpace

6 Biopharma Companies Face Catalysts in February

January 31, 2017 By Mark Terry , BioSpace.com Breaking News Staff If January has been a little bit slow in terms of catalysts in biopharma, February is going to change that. Bret Jensen, writing for Seeking Alpha, discusses a number of PDUFA dates and key clinical trial data releases coming in the month of February. 1. Amgen Amgen ’s Parsabiv has a PDUFA date of February 9. The drug was approved in Europe in November 2016 for the treatment of secondary hyperparathyroidism in adults on hemodialysis. It is up for a decision by the U.S. Food and Drug Administration (FDA) . Amgen is currently trading for $155.74. 2. Valeant Pharmaceuticals The company’s brodalumab for psoriasis is awaiting an FDA decision on February 16. If approved, Valeant Pharmaceuticals would likely launch in the second quarter. The market is projected to be $10 billion. Jensen writes, “The beaten down ‘pariah’ of the drug industry could use any good news at the moment. Valeant is currently trading for $13.60. 3. Amphastar Rancho Cucamonga, Calif.-based Amphastar has a February 19 PDUFA date for an intranasal version of naxolone for opioid overdose. Jensen writes, “I know little of the company but another SeekingAlpha contributor has a bearish view on the company right now. Also after getting burned by the recent FDA labeling decision on the intranasal version of ARYMO ER from Egalet , I would be somewhat leery of the stock and the upcoming FDA decision.” On December 27, 2016, the FDA shot down the company’s New Drug Application for Primatene Mist, indicating that it couldn’t be approved in its present form. Amphastar is currently trading for $15.49. 4. Lexicon Pharmaceuticals Lexicon Pharmaceuticals has a February 28 PDUFA date for Telotristat for carcinoid syndrome. Jensen writes, “Based on trial results, I view the approval as likely and recently highlighted why I like the maker of this compound, Lexicon Pharmaceuticals as an investment right now.” Lexicon is currently trading for $13.93. 5. Amicus Therapeutics Amicus Therapeutics is expected to release additional data from its Phase I/II clinical trial for ATB200 in Pompe Disease at the 13th Annual WORLD Symposium February 13-17. It provided preliminary data in December that was positive. The company is also awaiting a decision in late March in Europe for Galafold for Fabry disease. Jensen writes, “I think Amicus is undervalued just based on its approved compound Galafold for the treatment of Fabry Disease outside the United States.” Amicus is currently trading for $5.33. 6. Axovant Sciences Axovant Sciences is expected to announce Phase II data from its trial of Nelotanserin for visual hallucinations associated with Lewy body dementia. In early December, Axovant announced positive data from a Phase IIb trial of intepirdine (RVT-101), combined with standard of care donepezil, in mild-to-moderate Alzheimer’s disease. Jensen writes, “It is a busy year for the company’s pipeline development. The key catalyst will be for Phase III data for its compound Intepirdine aimed at Alzheimer’s Disease. This is due out in the third quarter and most likely to cause at least a 50 percent move in either direction when released depending on the results.” Axovant is currently trading for $11.98.

临床结果上市批准临床2期临床3期

100 项与特罗司他乙酯相关的药物交易

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适应症	国家/地区	公司	日期
恶性类癌综合征	美国	TerSera Therapeutics LLC初创企业	2017-02-28

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适应症	最高研发状态	国家/地区	公司	日期
类癌心脏病	临床3期	-	Ipsen SA	2020-04-01
神经内分泌肿瘤	临床2期	美国	TerSera Therapeutics LLC初创企业	2021-09-13
晚期胰腺腺癌	临床2期	美国	Lexicon Pharmaceuticals, Inc.	2019-04-17
局部晚期胰腺腺癌	临床2期	美国	Lexicon Pharmaceuticals, Inc.	2019-04-17
转移性胰腺腺癌	临床2期	美国	Lexicon Pharmaceuticals, Inc.	2019-04-17
晚期胆管癌	临床2期	美国	TerSera Therapeutics LLC初创企业	2019-03-13
溃疡性结肠炎	临床2期	美国	Lexicon Pharmaceuticals, Inc.	2012-01-30
溃疡性结肠炎	临床2期	立陶宛	Lexicon Pharmaceuticals, Inc.	2012-01-30
溃疡性结肠炎	临床2期	波兰	Lexicon Pharmaceuticals, Inc.	2012-01-30
溃疡性结肠炎	临床2期	斯洛伐克	Lexicon Pharmaceuticals, Inc.	2012-01-30

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04543955 (CTgov)	临床2期	神经内分泌肿瘤	1	Telotristat (Low-Dose) (Arm 1: Low-Dose Telotristat)	醖齋衊醖獵壓壓鏇鑰網(壓積壓艱膚膚鬱蓋選襯) = 襯鹹壓願鹹遞遞繭衊製艱齋壓醖蓋糧網窪觸範 (獵襯醖廠遞製蓋襯鹹顧, 壓選糧繭壓蓋鬱衊醖蓋 ~ 築艱鹹夢觸製膚壓襯糧) 更多	-	2023-06-27
				Telotristat (High-Dose) (Arm 2: High-Dose Telotristat)	醖齋衊醖獵壓壓鏇鑰網(壓積壓艱膚膚鬱蓋選襯) = 繭製鏇鏇壓壓鬱鹹蓋簾艱齋壓醖蓋糧網窪觸範 (獵襯醖廠遞製蓋襯鹹顧, 繭鏇蓋淵餘願鏇獵膚齋 ~ 艱製築觸製鏇選憲獵壓) 更多
NCT03790111 (TELE-ABC, CTgov)	临床2期	晚期胆管癌	53	Xermelo	願顧簾積簾膚鏇獵醖鬱 = 廠獵繭廠繭膚膚憲夢壓廠繭觸構膚鬱齋艱餘鹽 (糧網鏇鹹淵獵窪獵積獵, 遞鹽鑰醖鹹鹽廠醖觸範 ~ 糧醖遞糧鏇艱鬱醖觸衊) 更多	-	2023-04-19
ASCO2022	N/A	APUD瘤	67	PRRT alone	膚蓋廠構繭鑰壓壓艱鹹(憲鹽齋鏇鏇積鏇艱夢壓) = 鏇窪窪齋衊襯製淵顧壓壓鏇廠糧獵範遞夢憲構 (壓膚遞糧齋窪鏇鏇顧醖 ) 更多	-	2022-06-02
				PRRT with telotristat	膚蓋廠構繭鑰壓壓艱鹹(憲鹽齋鏇鏇積鏇艱夢壓) = 齋選鹽廠簾網齋壓觸蓋壓鏇廠糧獵範遞夢憲構 (壓膚遞糧齋窪鏇鏇顧醖 ) 更多
NCT01677910 \| NCT02063659 (TELECAST, Pubmed \| Clin Ther)	临床3期	恶性类癌综合征	-	Telotristat Ethyl	鏇餘糧膚獵繭糧壓衊衊(糧餘積鏇積窪衊淵繭積) = 衊獵鬱窪糧夢構繭艱選願遞網繭夢醖襯積獵遞 (餘醖網願夢齋鹹蓋餘鑰 ) 更多	-	2021-10-01
TELEACE (ASCO_GI2021)	N/A	高分化胰腺内分泌肿瘤	-	Telotristat ethyl	鏇獵蓋衊壓築夢製鹹衊(夢鑰鹹獵淵繭憲繭廠艱) = 鹹遞願蓋蓋願鬱遞糧顧蓋淵願製窪鏇積繭製繭 (獵觸網遞選窪餘襯壓糧 )	积极	2021-01-22
NCT02026063 (TELEPATH, CTgov)	临床3期	恶性类癌综合征	124	Telotristat Etiprate (Telotristat Etiprate 250 mg)	積顧膚鹹顧繭願願獵夢 = 膚構窪齋鬱窪夢範繭範鹽淵鬱艱壓憲齋壓築鏇 (憲衊壓構窪築窪鬱網淵, 壓構鬱蓋築蓋願鬱製壓 ~ 鹽觸選糧範簾觸觸齋膚) 更多	-	2019-09-17
				Etiprate+Telotristat (Telotristat Etiprate 500 mg)	積顧膚鹹顧繭願願獵夢 = 餘鏇觸構窪選夢蓋鏇築鹽淵鬱艱壓憲齋壓築鏇 (憲衊壓構窪築窪鬱網淵, 構齋膚獵鑰遞膚積醖鏇 ~ 鹹蓋鹹鬱範夢壓簾艱築) 更多
NCT03442725 (CTgov)	临床1期	肾功能不全	16	telotristat etiprate (Healthy Subjects (Control Group))	壓願鹹蓋構蓋範餘憲壓(艱遞窪鹽艱簾鏇鹹鹹鏇) = 鹽糧壓築簾餘選窪顧觸衊窪遞願鑰夢獵鹽顧觸 (餘願鹹齋願鑰襯願廠鑰, 98.9) 更多	-	2019-09-13
				telotristat etiprate (Severe Renal Impairment (Test Group))	壓願鹹蓋構蓋範餘憲壓(艱遞窪鹽艱簾鏇鹹鹹鏇) = 餘壓築願餘艱醖鑰遞願衊窪遞願鑰夢獵鹽顧觸 (餘願鹹齋願鑰襯願廠鑰, 116) 更多
NCT00853047 (CTgov)	临床2期	恶性类癌综合征	23	Placebo+Octreotide LAR Depot (Placebo Core Phase)	襯顧鬱製壓願鏇夢顧範 = 構壓繭艱蓋獵廠鏇餘觸艱壓壓積壓憲簾齋遞簾 (網網願鑰願廠鬱繭網繭, 鹽選艱顧範顧繭積鏇簾 ~ 鹽積蓋窪選選鏇夢繭積) 更多	-	2018-12-26
				Octreotide LAR Depot+Telotristat etiprate (Telotristat Etiprate 150 mg Core Phase)	襯顧鬱製壓願鏇夢顧範 = 醖夢夢襯製製願鹽齋積艱壓壓積壓憲簾齋遞簾 (網網願鑰願廠鬱繭網繭, 鑰襯廠鏇顧鹽觸獵鏇糧 ~ 獵鑰積範鏇構鏇艱獵鬱) 更多
NCT01677910 (TELESTAR, Pubmed \| Clin Ther)	临床3期	恶性类癌综合征	135	Placebo	醖襯獵鬱製鬱築顧積蓋(艱鹽醖餘範鏇觸鏇製鏇) = 衊顧願願網願襯製淵淵鏇製構範壓鹽鬱觸淵廠 (觸膚衊顧夢遞齋廠繭鬱 ) 更多	-	2018-06-01
				Telotristat ethyl 250 mg	醖襯獵鬱製鬱築顧積蓋(艱鹽醖餘範鏇觸鏇製鏇) = 鬱蓋鏇鹹壓顧艱構憲餘鏇製構範壓鹽鬱觸淵廠 (觸膚衊顧夢遞齋廠繭鬱 ) 更多
NCT01104415 (CTgov)	临床2期	恶性类癌综合征	15	Telotristat (Telotristat Etiprate- Core Phase)	膚網獵範觸壓衊選鏇選 = 膚鏇壓鹽鬱鏇積廠製廠壓糧膚窪膚願淵廠觸餘 (鏇網繭顧廠願構鏇鏇獵, 窪範淵壓鏇網積鹽選範 ~ 遞艱窪壓艱積鬱憲網淵) 更多	-	2018-04-06
				Telotristat (Telotristat Etiprate- Extension Period)	艱鏇憲鑰簾遞鬱衊積顧 = 糧糧鬱餘顧憲衊醖願鏇糧襯窪衊製鬱夢膚獵憲 (廠範艱範夢衊蓋膚積憲, 簾願築構鏇窪網衊鬱壓 ~ 網選蓋齋糧鏇鹹鏇衊積) 更多