预约演示
更新于：2026-04-25
Albumin-Bound Paclitaxel
白蛋白结合型紫杉醇
更新于：2026-04-25
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2005-01-07), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C47H51NO14 |
InChIKeyRCINICONZNJXQF-MZXODVADSA-N |
CAS号33069-62-4 |
关联
2,375
项与 白蛋白结合型紫杉醇 相关的临床试验NCT06592664
A Phase 1b/2a, Double-blind, Placebo-controlled, Three Arm, Randomized Study Evaluating a Single Intravenous Push Followed by a Continuous Infusion of Certepetide Over 4 Hours When Added to Standard of Care (SoC) Versus Two Intravenous Pushes of Certepetide When Added to SoC, Versus SoC Alone in Subjects With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma (FORTIFIDE)
The goal of this clinical trial is to test a new drug plus standard treatment compared with standard treatment alone in people with metastatic pancreatic ductal adenocarcinoma.
The main questions it aims to answer are:
* is the new drug plus standard treatment safe and tolerable
* is the new drug plus standard treatment more effective than standard treatment
Participants will:
* Visit the clinic three times every 28 days for treatment and tests
* Have CT or MRI scans every 8 weeks while on treatment
The main questions it aims to answer are:
* is the new drug plus standard treatment safe and tolerable
* is the new drug plus standard treatment more effective than standard treatment
Participants will:
* Visit the clinic three times every 28 days for treatment and tests
* Have CT or MRI scans every 8 weeks while on treatment
开始日期2030-01-01 |
申办/合作机构 |
NCT07253662
Phase I Trial of Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Patients With Peritoneal Metastasis From Pancreatic Adenocarcinoma
Palliative systemic therapy is the standard treatment option for patients with pancreatic ductal adenocarcinoma (PDAC) and peritoneal metastasis (PM), who have a median overall survival of only 6-11 months and a serious adverse event (SAE) rate of >5%. Patients with peritoneal-only metastasis may demonstrate unique tumor biology with less potential for hematogenous and lymphatic spread, making them potential candidates for a regional approach directed at the peritoneum. PIPAC is a drug- delivery system that combines the pharmacokinetic advantages of low- dose intraperitoneal chemotherapy (high tumor tissue penetration with low systemic absorption/toxicity) with the principles of aerosolization (homogenous intraperitoneal distribution and deeper tissue penetration). PIPAC may offer a complimentary approach to maximize drug delivery to tumor implants, potentially improving quality of life and survival without significant additional morbidity. Several non-randomized studies have evaluated safety, feasibility, and efficacy of PIPAC with various intraperitoneal agents in a variety of tumor types. Very few patients with pancreatic cancer PM have been included in these studies and most have been treated with either PIPAC-oxaliplatin or doxorubicin/cisplatin. A recent phase 1 dose-escalation study included patients with ovarian, gastric, breast, and hepatopancreatobiliary malignancies. One patient with
pancreatic cancer was included in this study. The recommended phase 2 dose was 140 mg/m2, with guidance to decrease the dose to 112.5 mg/m2 in patients with hepatic impairment. Therefore, the dose utilized in this study is 112.5 mg/m2. This recommendation was based on concern for nab-paclitaxel hepatotoxicity, but there was no data presented to support this expert recommendation.
This study sets out to explore the role of PIPAC with nab-paclitaxel in combination with medical oncology choice standard of care therapy in this patient population.
pancreatic cancer was included in this study. The recommended phase 2 dose was 140 mg/m2, with guidance to decrease the dose to 112.5 mg/m2 in patients with hepatic impairment. Therefore, the dose utilized in this study is 112.5 mg/m2. This recommendation was based on concern for nab-paclitaxel hepatotoxicity, but there was no data presented to support this expert recommendation.
This study sets out to explore the role of PIPAC with nab-paclitaxel in combination with medical oncology choice standard of care therapy in this patient population.
开始日期2026-12-30 |
申办/合作机构 |
NCT07465757
A Phase 2 Study of Alisertib in Combination With Paclitaxel in Patients With Small Cell Lung Cancer
The goal of this clinical trial is to determine how well people tolerate treatment with alisertib at different doses when it is used together with paclitaxel to treat people with SCLC. The main question it aims to answer is:
* What percentage of side effects, both mild and serious, do participants experience when being treated with alisertib and paclitaxel based on the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 (NCI CTCAE v.5.0)?
The study will consist of different groups, called cohorts, in which alisertib will be studied at increasing doses. Participants in the first group, Cohort 1, will take 30 mg of alisertib by mouth 2 times a day. The dose will increase by 10 mg 2 times a day for each new cohort of participants joining the study. Side effects will be checked during the study, and the decision to increase the dose of alisertib will be based on the specific side effects experienced during the first 21 days of treatment for each cohort.
Participants will:
* take alisertib by mouth on their own 2 times a day from Day 1 through Day 7 of each 21-day cycle and will be given paclitaxel intravenously at a dose of 60 mg/m2 on Day 1 and Day 8 of each 21-day cycle.
* be given a preventive treatment to increase their body defenses, called granulocyte-colony stimulating factor (G-CSF). Study staff will give G-CSF after the last dose of alisertib or paclitaxel of each 21-day cycle in which alisertib was given.
* provide blood samples to evaluate the different levels of alisertib in the blood at different times. Blood samples will be collected on Days 1 and 7 of the first and second 21-day cycles of treatment.
* be treated with alisertib and paclitaxel until death, worsening of the disease, unacceptable toxicity, unwillingness to continue participating in the trial, or other criteria that requires participants to stop treatment and participation in the study.
* be contacted every 8 weeks after stopping alisertib and paclitaxel treatment as part of a specific study phase called the long-term follow-up period. This will last until death, unwillingness to continue participating in the trial, or until the end of the study.
* What percentage of side effects, both mild and serious, do participants experience when being treated with alisertib and paclitaxel based on the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 (NCI CTCAE v.5.0)?
The study will consist of different groups, called cohorts, in which alisertib will be studied at increasing doses. Participants in the first group, Cohort 1, will take 30 mg of alisertib by mouth 2 times a day. The dose will increase by 10 mg 2 times a day for each new cohort of participants joining the study. Side effects will be checked during the study, and the decision to increase the dose of alisertib will be based on the specific side effects experienced during the first 21 days of treatment for each cohort.
Participants will:
* take alisertib by mouth on their own 2 times a day from Day 1 through Day 7 of each 21-day cycle and will be given paclitaxel intravenously at a dose of 60 mg/m2 on Day 1 and Day 8 of each 21-day cycle.
* be given a preventive treatment to increase their body defenses, called granulocyte-colony stimulating factor (G-CSF). Study staff will give G-CSF after the last dose of alisertib or paclitaxel of each 21-day cycle in which alisertib was given.
* provide blood samples to evaluate the different levels of alisertib in the blood at different times. Blood samples will be collected on Days 1 and 7 of the first and second 21-day cycles of treatment.
* be treated with alisertib and paclitaxel until death, worsening of the disease, unacceptable toxicity, unwillingness to continue participating in the trial, or other criteria that requires participants to stop treatment and participation in the study.
* be contacted every 8 weeks after stopping alisertib and paclitaxel treatment as part of a specific study phase called the long-term follow-up period. This will last until death, unwillingness to continue participating in the trial, or until the end of the study.
开始日期2026-09-30 |
申办/合作机构 |
100 项与 白蛋白结合型紫杉醇 相关的临床结果
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100 项与 白蛋白结合型紫杉醇 相关的转化医学
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100 项与 白蛋白结合型紫杉醇 相关的专利（医药）
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29,852
项与 白蛋白结合型紫杉醇 相关的文献（医药）2026-12-31·Future Science OA
Clinical efficacy of 2-week and 3-week albumin-bound paclitaxel therapy for advanced pancreatic cancer
Article
作者: Su, Zhimin ; Li, Zhiyong ; Shen, Feng ; Jiang, Jiana
OBJECTIVE:
We aim to compare the clinical efficacy and safety of albumin-bound paclitaxel (nab-PTX) (125 mg/m2, q2w) for two weeks and (125 mg/m2, d1, d8, q3w) for three weeks in the first-line treatment of advanced pancreatic cancer.
METHODS:
The medical records of patients with advanced pancreatic cancer who received nab-PTX for 2 weeks and 3 weeks, combined with gemcitabine, from July 2018 to January 2023, were retrospectively analyzed. The efficacy and adverse reactions of the two groups of patients were compared.
RESULT:
A total of 64 patients were included. The median progression-free survival (mPFS) of the 2-week group was 5.6 months, while the 3-week group was 7.8 months. The median overall survival (mOS) of the 2-week group was 14.0 months, while the 3-week group was 14.7 months. The multivariate analysis showed that a physical fitness status score of 0-1 was an independent factor with better OS, while metastatic sites ≥ 3 were related to poor OS. The incidence of leukopenia or neutropenia, neurotoxicity, fatigue, and poor appetite in the 2-week group was lower than that in the 3-week group.
CONCLUSION:
The clinical efficacy of nab-PTX in the 2-week and dose intensive 3 week did not show significant difference, but the 2-week treatment group had better tolerance and safety.
2026-12-31·DRUG DELIVERY
The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity
Article
作者: Jiang, Chengwei ; Schätzlein, Andreas G. ; Uchegbu, Ijeoma F. ; Xiong, Guojun
Human serum albumin (HSA) has attracted significant attention in drug delivery since the approval of Abraxane in 2005. Abraxane is a nanoparticle albumin-bound paclitaxel (nab-PTX) formulation. Although HSA offers advantages such as prolonged circulation time (half-life ~19 days) and intrinsic hydrophobic pockets, the translation of other HSA-based nanomedicines remains limited. In fact, the significant differences between native and pharmaceutical HSA in protein structure and biological interactions could hinder their translational use in drug delivery. In this study, we demonstrate that pharmaceutical HSA (α-helix = 17%) is structurally denatured compared with native HSA (α-helix = 68%), leading to rapid clearance (<1 h) from the circulation and that drug loading is driven by pharmaceutical HSA's amphiphilicity rather than by its hydrophobic pockets. Here, we revealed that Nab-PTX is composed of protein-coated PTX solid cores. These nanosystems have insufficient surface charge (ζ = -13.7 mV), leading to aggregation, and low colloidal stability, resulting in premature drug release upon dilution (<0.1 mg/mL). To address these shortcomings, we developed HSA-polylactic acid (HSA-PLA) nanoparticles with enhanced negative surface charge (ζ = -27.4 mV) and improved colloidal stability to reduce the premature release of encapsulated PTX upon dilution (<0.01 mg/mL). In tumor models, comparative pharmacokinetics, biodistribution, and efficacy studies demonstrated that HSA-PLA (PTX) nanoparticles reduce premature drug release, resulting in greater tumor exposure (129 ± 3 vs. 90 ± 12 µg·h/g, p < 0.01) and superior antitumor efficacy compared with Abraxane. These improvements further suggest that optimization may require only a simple modification when guided by proper theoretical principles.
2026-06-01·ADVANCED DRUG DELIVERY REVIEWS
Protein-based nanocarriers in the management of hard-to-treat solid tumours
Review
作者: Evtushenko, Alexander S ; Fruk, Ljiljana ; Torres, Beatriz Lozano
Despite a steady decline in overall cancer mortality, the survival rates of certain hard-to-treat cancers of the lung, liver, oesophagus, pancreas, and brain remain strikingly low. A key unmet need in this field is the development of effective systemic therapies, for which nanotechnology offers promising solutions. While liposomal formulations have dominated the clinical landscape in oncology, protein-based nanocarriers (NCs) have emerged as biocompatible and biodegradable alternatives with intrinsic biological activity. The most notable example, nanoparticle albumin-bound (nab-)paclitaxel, has been in clinical use since 2005, however the development of new protein-based NCs has since largely stagnated for various reasons. For instance, while albumin has been employed in NC formulation since 1978, its intracellular trafficking remains poorly understood, and the proposed mechanism of tumour uptake based on glycoprotein 60-mediated transcytosis is not supported by adequate evidence. Beyond albumin, twelve other proteins have been explored for NC formulation in hard-to-treat cancers, yet none have progressed to clinical trials due to challenges with reproducibly and immunogenicity. Furthermore, conventional NC fabrication methods such as desolvation and homogenisation face stability and biocompatibility issues, limiting clinical translation. Additional hurdles include suboptimal choice of drug cargo, insufficient tumour targeting, and inadequate preclinical biological validation. To address these issues, this review critically evaluates the current landscape of protein-based NCs (including all multi-protein assemblies in the nature of nab-paclitaxel but excluding antibody-drug conjugates and virus-like nanoparticles) in the context of hard-to-treat cancers and highlights practical strategies to overcome their limitations with the goal of advancing these NCs towards clinical implementation.
2,802
项与 白蛋白结合型紫杉醇 相关的新闻（医药）2026-04-24
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截至04月24日15点59分，近期共有 496 本期刊发布了 988 篇文章，其中糖尿病相关的文章共 308 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 74 篇。今日，影响因子最高的文章刊登在 The Lancet (IF: 88.500) 期刊上。
今日头条
Headlines
01 Lancet Diabetes Endocrinol IF: 41.800 持续葡萄糖监测对比自我血糖监测在2型糖尿病患者中的随机、多中心、开放标签、优效性试验
Emma G Wilmot, Patrick Moore, Thozhukat Sathyapalan, Pratik Choudhary, Jonathan Z M Lim, Sankalpa Neupane, etc.
FreeDM2研究是一项在英国24个中心进行的开放标签、随机对照试验，旨在评估实时持续葡萄糖监测（CGM）对比自我血糖监测（SMBG）在2型糖尿病成人患者中的有效性和安全性。研究纳入303例使用基础胰岛素联合SGLT2抑制剂或GLP-1受体激动剂或双重GIP/GLP-1受体激动剂治疗但血糖控制不佳（糖化血红蛋白[HbA1c] 7.5%-11.0%）的患者，按2:1随机分配至CGM组（198例）或SMBG组（105例）。
试验采用独特的两阶段设计：第1-16周为自我管理阶段，患者根据CGM或SMBG数据自行调整基础胰岛素；第17-32周为临床支持阶段，医生可根据血糖数据加用其他降糖药物。
结果显示，在16周时，CGM组HbA1c从基线8.8%降至8.0%，而SMBG组仍为8.7%，校正后组间差异为-0.6%（95% CI -0.8~-0.3，P<0.0001）。在32周时，CGM组HbA1c进一步降至7.8%，SMBG组为8.3%，差异为-0.5%（95% CI -0.7~-0.2，P<0.0001）。CGM组达到HbA1c≤7.0%的比例在16周时为15%，而SMBG组仅为2%。
CGM组的目标范围内（3.9-10.0 mmol/L）时间显著增加，高血糖时间显著减少。两组低血糖时间均很低且相似。在自我管理阶段，尽管胰岛素剂量无组间差异，CGM组血糖改善更显著，提示获益可能源于生活方式改变。加速度计数据显示，16周时CGM组总体力活动轻度增加，饮食质量评分改善。
患者报告结局方面，CGM组对血糖监测的满意度更高，低血糖信心量表评分改善。安全性方面，两组非器械相关不良事件发生率相似，对照组发生2例严重低血糖，CGM组无严重低血糖事件。
研究结论认为，在基础胰岛素联合新型药物治疗的2型糖尿病患者中，实时CGM相比SMBG可显著改善血糖控制，且不增加低血糖风险，支持其在临床实践中的广泛应用。
本文由 韩玉莲 编辑
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Lancet Diabetes Endocrinol | Ahead of Print.
10.1016/S2213-8587(26)00076-8
02 Frontiers in endocrinology IF: 04.600 长期控制良好的1型糖尿病患者中小而密低密度脂蛋白谱的改变
Sardà, Helena, Solé, Arnau, Colom, Cristina, Borràs, Carla, Carreras, Gemma, Benítez, Sonia, etc.
一项发表于《Frontiers in Endocrinology》的横断面观察研究显示，长期血糖控制良好的1型糖尿病患者仍存在致动脉粥样硬化的小而密低密度脂蛋白（LDL）谱改变。
研究纳入69例病程较长的1型糖尿病患者和24名健康对照，所有患者平均糖化血红蛋白（HbA1c）为7.6%，血脂水平接近正常。结果显示，与对照组相比，1型糖尿病患者的小而密低密度脂蛋白胆固醇（LDL-C）浓度显著升高（0.56 vs. 0.43 mmol/L），小而密LDL-C/LDL-C比值增加（0.20 vs. 0.12），LDL颗粒直径减小（26.32 vs. 26.81 nm）。
在脂蛋白代谢调节因子方面，1型糖尿病患者的载脂蛋白C3浓度（8.67 vs. 6.53 mg/dL）、肝脂肪酶质量（46.60 vs. 15.45 ng/mL）和活性（1.03 vs. 0.89 U/mL）均显著高于对照组，而胆固醇酯转移蛋白活性显著降低（808.8 vs. 929.7 pmol/mL/h），内皮脂肪酶水平无显著差异。
相关性分析显示，小而密LDL-C与载脂蛋白C3呈显著正相关（r=0.7517），与胆固醇酯转移蛋白活性呈负相关（r=-0.2682）。
研究提示，即使传统血脂指标正常，1型糖尿病患者仍存在小而密LDL富集，这可能与载脂蛋白C3升高、肝脂肪酶活性增加和胆固醇酯转移蛋白活性降低有关。直接检测小而密LDL可能有助于更准确地评估该人群的心血管风险。
本文由 韩玉莲 编辑
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Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1804987
03 Diabetes, obesity & metabolism IF: 05.700 每天一次口服司美格鲁肽25 mg vs. 皮下注射司美格鲁肽2.4 mg用于伴或不伴2型糖尿病的肥胖症的有效性、安全性和药代动力学：——模型指导的药物开发方法
Overgaard, Rune Viig, Birkhan, Oscar, Rathor, Naveen, Sparsø, Thomas, Strathe, Anders, Wharton, Sean, etc.
一项基于模型指导的药物开发研究评估了每天一次口服司美格鲁肽25 mg在肥胖症患者中的有效性、安全性和药代动力学，并与已获批的皮下注射司美格鲁肽2.4 mg进行比较。研究利用历史数据和OASIS项目数据，通过群体药代动力学和暴露-反应分析，模拟了虚拟的II期和III期临床试验。
结果显示，在OASIS 4试验中，82.2%接受口服司美格鲁肽25 mg治疗的患者达到了与STEP 1试验中每周一次皮下注射司美格鲁肽2.4 mg患者相似的暴露水平。在模拟的虚拟试验中，对于超重/肥胖伴2型糖尿病的患者，口服司美格鲁肽25 mg相比安慰剂实现了显著更大的体重降幅：试验产品估计为9.4%，治疗策略估计为7.8%。对于超重/肥胖不伴2型糖尿病的患者，体重降幅分别为16.3%和14.7%。
研究结论认为，口服司美格鲁肽25 mg的估计暴露水平和有效性观察结果与皮下注射司美格鲁肽2.4 mg相似，这支持了口服司美格鲁肽25 mg用于治疗伴或不伴2型糖尿病的肥胖症患者。该研究为口服司美格鲁肽25 mg的监管批准提供了药代动力学和有效性方面的证据支持。
本文由 天纳乾坤 编辑
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Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70769
中国发表（74）
China
Molecular medicine IF: 06.400Ahead of Print.No.01Fludarabine disrupts the STAT1/AhR interaction to attenuate type 1 diabetes by inducing tolerogenic dendritic cells along with targeting effector T cells氟达拉滨通过破坏STAT1/AhR相互作用，诱导耐受性树突状细胞并靶向效应T细胞，从而减轻1型糖尿病DOI: 10.1186/s10020-026-01483-8
Cellular signalling IF: 03.700Ahead of Print.No.02Reactivating mitochondrial quality control via the Nrf2 pathway to combat metabolic stress in diabetic osteoarthritis通过Nrf2通路重新激活线粒体质量控制以对抗糖尿病性骨关节炎中的代谢应激DOI: 10.1016/j.cellsig.2026.112545
Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.03Parabens exposure, depression, and cardiovascular metabolic health in the elderly: Findings from a cross-sectional study in China老年人对羟基苯甲酸酯暴露、抑郁与心血管代谢健康：一项中国横断面研究结果DOI: 10.1016/j.ecoenv.2026.120153
European journal of pharmacology IF: 04.700Ahead of Print.No.04Corrigendum to "Cinnamaldehyde ameliorates diabetic kidney disease via anti-inflammatory effects: Bridging traditional use and molecular mechanisms" [Eur. J. Pharmacol. (2026) doi: 10.1016/j.ejphar.2026.178783]对《肉桂醛通过抗炎作用改善糖尿病肾病：传统应用与分子机制的桥梁》[Eur. J. Pharmacol. (2026) doi: 10.1016/j.ejphar.2026.178783]的勘误DOI: 10.1016/j.ejphar.2026.178883
Primary care diabetes IF: 02.300Ahead of Print.No.05The impact of sarcopenia on clinical outcomes in patients with diabetes: A systematic review and meta-analysis of cohort studies肌少症对糖尿病患者临床结局影响的系统评价与Meta分析DOI: 10.1016/j.pcd.2026.04.008
Life sciences IF: 05.100Volume 395, Issue No.06Myocardin-related transcription factor A contributes to diabetic nephropathy by activating integrin β2 in macrophages心肌相关转录因子A通过激活巨噬细胞中的整合素β2促进糖尿病肾病DOI: 10.1016/j.lfs.2026.124394
Journal of chromatography IF: 04.000Volume 1777, Issue No.07Rapid separation and enrichment of emodin and rhein in Sanhuang Xiexin Decoction by molecularly imprinted nanoparticles and evaluation of DPP-4 inhibitory activity分子印迹纳米颗粒快速分离富集三黄泻心汤中大黄素和大黄酸及DPP-4抑制活性评价DOI: 10.1016/j.chroma.2026.466979
Acta biomaterialia IF: 09.600Ahead of Print.No.08Adhesive polyethylene glycol hydrogels with metformin enabling in-situ drug delivery reprogramming immuno-metabolism for tissue repair in diabetic foot ulcers含二甲双胍的粘附性聚乙二醇水凝胶通过原位药物递送重编程免疫代谢促进糖尿病足溃疡组织修复DOI: 10.1016/j.actbio.2026.04.033
Life sciences IF: 05.100Ahead of Print.No.09Toward metabolic precision medicine in heart failure: Timing, tissue specificity, and network reconstruction迈向心力衰竭的代谢精准医学：时机、组织特异性和网络重建DOI: 10.1016/j.lfs.2026.124413
Journal of affective disorders IF: 04.900Ahead of Print.No.10Peripheral inflammation mediates the association between triglyceride-glucose index and cognitive impairment in comorbid major depressive disorder and type 2 diabetes: Translational implications for Alzheimer's disease risk via neuroinflammatory pathways外周炎症介导甘油三酯-葡萄糖指数与共病重度抑郁障碍和2型糖尿病认知障碍的关联：通过神经炎症通路对阿尔茨海默病风险的转化意义DOI: 10.1016/j.jad.2026.121830
Ecotoxicol Environ Saf IF: 06.100Ahead of Print.No.11Tryptophan metabolism in neonicotinoids exposure-induced diabetes: Emerging insights and predictive implications新烟碱类杀虫剂暴露诱发糖尿病中的色氨酸代谢：新见解与预测意义DOI: 10.1016/j.ecoenv.2026.120168
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.12Bioelectrical impedance analysis-derived phase angle predicts sarcopenia in older adults with type 2 diabetes mellitus生物电阻抗分析衍生的相位角预测老年2型糖尿病患者的肌少症DOI: 10.1016/j.endien.2026.501717
Journal of hazardous materials IF: 11.300Ahead of Print.No.13Metabolite profiling of organophosphate ester exposure and type 2 diabetes mellitus risk: A metabolomics study in an epidemiological setting有机磷酸酯暴露与2型糖尿病风险的代谢物谱分析：一项流行病学背景下的代谢组学研究DOI: 10.1016/j.jhazmat.2026.142142
BMC surgery IF: 01.800Ahead of Print.No.14Case report: morbid obesity and lithotomy positioning: a high-risk triad with GCS leading to severe rhabdomyolysis with impending acute compartment syndrome following ovarian cancer cytoreduction病例报告：病态肥胖与截石位——卵巢癌减灭术后GCS导致严重横纹肌溶解并濒临急性筋膜室综合征的高危三联征DOI: 10.1186/s12893-026-03765-8
Nature communications IF: 15.700Ahead of Print.No.15EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodelingEBF2凝聚体通过ZFP423隔离和表观遗传重塑实现脂肪产热DOI: 10.1038/s41467-026-72233-x
Journal of Advanced Research IF: 13.000Ahead of Print.No.16SUMOylation-deficient TRPV1 in sensory neurons confers resistance to high-fat diet-induced obesity via enhanced sympathetic adipose innervation感觉神经元中SUMOylation缺陷的TRPV1通过增强交感神经脂肪支配抵抗高脂饮食诱导的肥胖DOI: 10.1016/j.jare.2026.04.053
Antioxidants & redox signaling IF: 06.100Ahead of Print.No.17Iron Metabolism and Adipose Tissue Homeostasis: Emerging Perspectives for Obesity Intervention铁代谢与脂肪组织稳态：肥胖干预的新视角DOI: 10.1177/15230864261443818
Phytomedicine IF: 08.300Ahead of Print.No.18Sesamin ameliorates high-fat diet-induced inflammation and metabolic dysfunction in pregnant uterine smooth muscle via cGAS-STING inhibition芝麻素通过抑制cGAS-STING通路改善高脂饮食诱导的妊娠子宫平滑肌炎症和代谢功能障碍DOI: 10.1016/j.phymed.2026.158182
International immunopharmacology IF: 04.700Ahead of Print.No.19Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis锌缺乏加重而补充锌通过Nrf2/HO-1介导的细胞焦亡减轻早期肥胖相关足细胞损伤DOI: 10.1016/j.intimp.2026.116703
Cell Mol Life Sci IF: 06.200Ahead of Print.No.20N6-methyladenosine (m6A) methylation in adipose tissue: role, regulation, and therapeutic potential脂肪组织中N6-甲基腺苷（m6A）甲基化的作用、调控及治疗潜力DOI: 10.1007/s00018-026-06201-5
Experimental gerontology IF: 04.300Ahead of Print.No.21Exploring the regulatory mechanisms of antidiabetic drugs on osteoporosis and Bone mineral density抗糖尿病药物对骨质疏松及骨密度调节机制的研究DOI: 10.1016/j.exger.2026.113142
Biochemical pharmacology IF: 05.600Ahead of Print.No.22Convergence of ER stress and ferroptosis in diabetic vasculopathy: therapeutic protection by ferrostatin-1内质网应激与铁死亡在糖尿病血管病变中的交汇：ferrostatin-1的治疗保护作用DOI: 10.1016/j.bcp.2026.117998
Eur J Med Chem IF: 05.900Ahead of Print.No.23Benzothiophene-based, orally active PIK3CA H1047R mutant-selective inhibitors for the treatment of HR+/HER2- breast cancer基于苯并噻吩的口服活性PIK3CA H1047R突变选择性抑制剂用于治疗HR+/HER2-乳腺癌DOI: 10.1016/j.ejmech.2026.118879
Pharmacological research IF: 10.500Ahead of Print.No.24Dual modulation of lipophagy: From molecular mechanisms to therapeutic interventions in cardiovascular health and disease脂噬的双重调控：从分子机制到心血管健康与疾病的治疗干预DOI: 10.1016/j.phrs.2026.108204
Experimental Eye Research IF: 02.700Ahead of Print.No.25TARGETING DRP1 ATTENUATES FERROPTOSIS AND DELAYS THE PROGRESSION OF DIABETIC RETINOPATHY靶向DRP1减轻铁死亡并延缓糖尿病视网膜病变进展DOI: 10.1016/j.exer.2026.111035
Nano letters IF: 09.100Ahead of Print.No.26Hybrid MXene/Hydrogel Integration with Modulated Bioactivities for Synergistic Diabetic Wound Therapy混合MXene/水凝胶整合调控生物活性用于协同糖尿病伤口治疗DOI: 10.1021/acs.nanolett.6c00565
J Neuropathol Exp Neurol IF: 03.000Ahead of Print.No.27The N6-methyladenosine (m6A) reader YTHDF3 increases PINK1/Parkin-mediated mitophagy by facilitating prohibitin 2 (PHB2) translation to promote retinal ganglion cell damage in diabetic retinopathym6A阅读蛋白YTHDF3通过促进prohibitin 2翻译增强PINK1/Parkin介导的线粒体自噬，加剧糖尿病视网膜病变中视网膜神经节细胞损伤DOI: 10.1093/jnen/nlag027
Cell biology and toxicology IF: 05.900Volume 42, Issue 1No.28Correction to: BMSC‑derived extracellular vesicles affect gluconeogenesis and lipogenesis by releasing 5'‑tRF‑GlyCCC to improve MAFLD insulin sensitivity更正：BMSC来源的细胞外囊泡通过释放5'-tRF-GlyCCC影响糖异生和脂肪生成以改善MAFLD胰岛素敏感性DOI: 10.1007/s10565-026-10187-y
Endocrine connections IF: 02.800Ahead of Print.No.29The IGF Signaling Axis in Thyroid Cancer: Biological Complexity and Therapeutic Challenges甲状腺癌中IGF信号轴：生物学复杂性与治疗挑战DOI: 10.1530/EC-26-0144
Hormones IF: 02.500Ahead of Print.No.30The association between the weight-adjusted waist circumference index (WWI) and thyroid function: an NHANES study体重调整腰围指数与甲状腺功能的关系：一项NHANES研究DOI: 10.1007/s42000-026-00781-4
The aging male IF: 02.600Volume 29, Issue 1No.31Relationship between Chinese visceral adiposity index and bone mineral density in patients with type 2 diabetes mellitus中国内脏脂肪指数与2型糖尿病患者骨密度的关系DOI: 10.1080/13685538.2026.2662050
Journal of diabetes IF: 03.700Volume 18, Issue 4No.32Atherogenic Index of Plasma Predicts the Onset and Progression of Cardio-Renal-Metabolic Multimorbidity: Evidence From a Nationwide Prospective Cohort Study血浆致动脉粥样硬化指数预测心肾代谢共病的发生和进展：来自全国前瞻性队列研究的证据DOI: 10.1111/1753-0407.70227
CNS neuroscience & therapeutics IF: 05.000Volume 32, Issue 4No.33Association of the Triglyceride-Glucose (TyG) Index and TyG-BMI With 1-Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion甘油三酯-葡萄糖指数和甘油三酯-葡萄糖-体重指数与急性基底动脉闭塞血管内治疗后1年结局的关联DOI: 10.1002/cns.70898
iScience IF: 04.100Volume 29, Issue 5No.34Neutrophils and neutrophil extracellular traps in diabetes mellitus and its complications: Mechanisms and therapeutic implications中性粒细胞和中性粒细胞胞外陷阱在糖尿病及其并发症中的作用：机制与治疗意义DOI: 10.1016/j.isci.2026.115585
Exp Ther Med IF: 02.300Volume 31, Issue 6No.35Interacting proteins of AMPK studied using TurboID proximity labeling technology使用TurboID邻近标记技术研究AMPK的相互作用蛋白DOI: 10.3892/etm.2026.13144
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.36Association of thyroid function and thyroid hormone sensitivity with all-cause and cardiovascular mortality in euthyroid patients with MASLD甲状腺功能及甲状腺激素敏感性与甲状腺功能正常的脂肪性肝病患者全因及心血管死亡率的关系DOI: 10.5114/ceh.2025.155479
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.37pH/ROS-responsive smart hydrogels for infection control and immune microenvironment modulation in chronic wound healingpH/ROS响应性智能水凝胶在慢性伤口愈合中的感染控制与免疫微环境调节DOI: 10.3389/fcell.2026.1826583
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.38Skin Organoids in Diabetic Chronic Wounds: Current Status and Future Perspectives皮肤类器官在糖尿病慢性创面中的应用：现状与未来展望DOI: 10.2147/DMSO.S598026
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.39Ferroptosis regulation by SGLT2 inhibitors: mechanisms and clinical benefits in diabetic kidney diseaseSGLT2抑制剂调控铁死亡：糖尿病肾脏病中的机制与临床获益DOI: 10.3389/fphar.2026.1808167
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Lysosomal dysfunction in diabetes and diabetic complications糖尿病及其并发症中的溶酶体功能障碍DOI: 10.3389/fendo.2026.1794600
Cardiology in the Young IF: 00.900Ahead of Print.No.41The impact of gestational diabetes mellitus on neonatal cardiac development妊娠期糖尿病对新生儿心脏发育的影响DOI: 10.1017/S1047951126112268
BMC pregnancy and childbirth IF: 02.700Ahead of Print.No.42Longitudinal metabolomics reveals dynamic associations of trimethylamine N-oxide and precursors with the progression of gestational diabetes纵向代谢组学揭示氧化三甲胺及其前体与妊娠期糖尿病进展的动态关联DOI: 10.1186/s12884-026-09088-z
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.43[Association Between Blood Routine Index and Metabolic Syndrome in High-altitude Tibetan Population]高原藏族人群血常规指标与代谢综合征的关联研究DOI: 10.12182/20260360506
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.44[Apply the Miettinen Formula to Assess the Health Benefits of the PM(2.5) Simulation Intervention on Metabolic Syndrome]应用Miettinen公式评估PM2.5模拟干预对代谢综合征的健康收益DOI: 10.12182/20260360102
Actas espa?olas de psiquiatría IF: 01.600Volume 54, Issue 2No.45Severity of Cognitive Impairment and Its Correlation With Depressive Symptoms and Influencing Factors in Elderly Patients With Chronic Diseases老年慢性病患者认知障碍严重程度及其与抑郁症状和相关因素的相关性DOI: 10.62641/aep.v54i2.2166
Frontiers in pediatrics IF: 02.000Volume 14, Issue No.46Maternal risk factors for biliary atresia in neonates: a systematic review and meta-analysis新生儿胆道闭锁的母体危险因素：系统评价与荟萃分析DOI: 10.3389/fped.2026.1817265
Sexual medicine IF: 02.000Volume 14, Issue 3No.47PPP1R14A in male erectile dysfunction: key role in smooth muscle cellsPPP1R14A在男性勃起功能障碍中的作用：平滑肌细胞的关键角色DOI: 10.1093/sexmed/qfag021
IbrainVolume 12, Issue 1No.48Development of a predictive model for depressive symptoms in type 2 diabetes mellitus patients under community management: Based on visual function index基于视觉功能指数的社区管理2型糖尿病患者抑郁症状预测模型开发DOI: 10.1002/ibra.70014
Frontiers in nutrition IF: 05.100Volume 13, Issue No.49Association of dietary phytochemical index with sleep quality, and inflammatory markers in adults with type 2 diabetes: a cross-sectional study膳食植物化学指数与2型糖尿病成人睡眠质量和炎症标志物的关联：一项横断面研究DOI: 10.3389/fnut.2026.1766495
Postgraduate medicine IF: 02.800Ahead of Print.No.50Nonlinear relationship between the CHG index and MASLD in type 2 diabetes mellitus: mediating role of immunoinflammatory markers2型糖尿病患者CHG指数与代谢功能障碍相关脂肪性肝病的非线性关系：免疫炎症标志物的中介作用DOI: 10.1080/00325481.2026.2661571
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.51Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus2型糖尿病患者血糖及血糖变异性、甲状腺激素与白蛋白尿的相关性DOI: 10.1002/kjm2.70221
Curēus IF: 01.300Volume 18, Issue 3No.52Capivasertib-Induced Diabetes Successfully Managed With Insulin-Independent Glucose-Lowering Agents: A Case Report卡匹色替诱导的糖尿病成功使用非胰岛素依赖的降糖药物管理：一例病例报告DOI: 10.7759/cureus.105623
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.53Analysis of the prevalence of dyslipidemia in early-onset schizophrenia patients and its correlation with clinical characteristics早发性精神分裂症患者血脂异常患病率及其与临床特征的相关性分析DOI: 10.3389/fpsyt.2026.1794475
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.54Systematic review of the efficacy and safety of biologically and tissue-derived therapies for the treatment of diabetic foot生物及组织来源疗法治疗糖尿病足的有效性和安全性的系统评价DOI: 10.3389/fendo.2026.1800592
Actas espa?olas de psiquiatría IF: 01.600Volume 54, Issue 2No.55Association Between Relative Fat Mass and Risk of Cognitive Impairment: The Role of Social Determinants of Health相对脂肪质量与认知障碍风险的关系：健康社会决定因素的作用DOI: 10.62641/aep.v54i2.2121
Food science & nutrition IF: 03.800Volume 14, Issue 4No.56Candidate Obesity Biomarkers Identified Through Multi-Omics Analysis, Mendelian Randomization, and Mediation Analysis通过多组学分析、孟德尔随机化和中介分析鉴定肥胖候选生物标志物DOI: 10.1002/fsn3.71803
Frontiers in nutrition IF: 05.100Volume 13, Issue No.57Correction: Comparative analysis of three BMI cutoffs for five metabolic abnormalities in the population of Western Guangdong, China更正：中国粤西地区人群中三种体重指数切点对五种代谢异常的比较分析DOI: 10.3389/fnut.2026.1835814
Brain and behavior IF: 02.700Volume 16, Issue 4No.58Association Between Visceral Adipose Tissue and Depression Risk With Both Observational and Genetic Evidence内脏脂肪组织与抑郁风险的关联：观察性和遗传学证据DOI: 10.1002/brb3.71392
Frontiers in veterinary science IF: 02.900Volume 13, Issue No.59From pathogenesis to prevention: an update on the management of obesity and its associated comorbidities in cats从发病机制到预防：猫肥胖及其相关合并症管理的最新进展DOI: 10.3389/fvets.2026.1797197
Biomedical chromatography IF: 01.700Volume 40, Issue 6No.60Study on Quality Markers for Hypoglycemic Effects of Moringa oleifera Leaves by the Integration of Network Pharmacology, Fingerprint, and Multi-Index Quantitative Analysis整合网络药理学、指纹图谱和多指标定量分析的辣木叶降糖有效性质量标志物研究DOI: 10.1002/bmc.70460
Actas espa?olas de psiquiatría IF: 01.600Volume 54, Issue 2No.61Association Between C-Reactive Protein-Triglyceride Glucose Index and Depressive Symptoms Among US Adults: A Nationally Representative Cross-Sectional Study From 2005 to 2023美国成年人C反应蛋白-甘油三酯葡萄糖指数与抑郁症状的关联：一项2005至2023年全国代表性横断面研究DOI: 10.62641/aep.v54i2.2163
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.62Sexually Dimorphic Impacts of Early Life BCAAs Supplementation on Metabolic Dysfunctions in Adult Mice早期支链氨基酸补充对成年小鼠代谢功能障碍的性别二态性影响DOI: 10.1111/dom.70809
Ecology and evolution IF: 02.300Volume 16, Issue 4No.63Comparative Genomics Reveals Genetic Adaptations to Diving-Associated Foraging in Anseriformes比较基因组学揭示雁形目潜水觅食相关遗传适应DOI: 10.1002/ece3.73551
Frontiers in immunology IF: 05.900Volume 17, Issue No.64Extracellular vesicles from Akkermansia muciniphila protect streptozotocin-induced diabetic mice by regulating glucose homeostasis, oxidative stress, and immune tolerance阿克曼菌来源的细胞外囊泡通过调节葡萄糖稳态、氧化应激和免疫耐受保护链脲佐菌素诱导的糖尿病小鼠DOI: 10.3389/fimmu.2026.1739048
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65The triglyceride-to-HDL cholesterol ratio is associated with lower BMD in older adults at high altitudes: a retrospective retrospective cross sectional study甘油三酯与高密度脂蛋白胆固醇比值与高海拔地区老年人骨密度降低相关：一项回顾性横断面研究DOI: 10.3389/fendo.2026.1809643
Frontiers in nutrition IF: 05.100Volume 13, Issue No.66Food-derived dihydromyricetin and metabolic dysfunction-associated steatotic liver disease: a preclinical systematic review and meta-analysis食物来源的二氢杨梅素与代谢功能障碍相关脂肪性肝病：临床前系统评价和荟萃分析DOI: 10.3389/fnut.2026.1786758
Cancer communications IF: 24.900Volume 46, Issue No.67Camrelizumab Plus Nab-paclitaxel in Patients with Previously Treated Advanced Urothelial Carcinoma: A Multicenter Phase II Study卡瑞利珠单抗联合白蛋白紫杉醇治疗既往经治晚期尿路上皮癌患者：一项多中心II期研究DOI: 10.34133/cancomm.0025
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.68[A Study of the Association and Interaction Between Organophosphorus Pesticide Exposure and Insulin Resistance in Non-diabetic Adults]非糖尿病成人有机磷农药暴露与胰岛素抵抗的关联及交互作用研究DOI: 10.12182/20260360103
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.69[A Study on the Association Between Various Insulin Resistance Assessment Indices and IVF-ET Outcomes in Patients With Polycystic Ovary Syndrome]多种胰岛素抵抗评估指标与多囊卵巢综合征患者体外受精-胚胎移植结局的关联研究DOI: 10.12182/20260360208
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.70Association between goiter and type 2 diabetes in a Chinese population: a cross-sectional study using CHNS data中国人群中甲状腺肿与2型糖尿病的关联：基于CHNS数据的横断面研究DOI: 10.3389/fendo.2026.1763534
Frontiers in immunology IF: 05.900Volume 17, Issue No.71Integrative analysis of transcriptomics, single-cell RNA sequencing, and GraphBAN identifies de novo lipogenesis-associated genes and their potential roles in diabetic retinopathy转录组学、单细胞RNA测序和GraphBAN的整合分析鉴定糖尿病视网膜病变中与从头脂肪生成相关的基因及其潜在作用DOI: 10.3389/fimmu.2026.1803639
Int J Endocrinol IF: 02.300Volume 2026, Issue No.72Dynapenic Abdominal Obesity and Cognitive Impairment in Type 2 Diabetic Patients: A Single-Center Cross-Sectional Study2型糖尿病患者中腹型肥胖与认知障碍的关系：一项单中心横断面研究DOI: 10.1155/ije/6060666
BMC endocrine disorders IF: 03.300Ahead of Print.No.73The role of serum miR-28-5p in predicting diabetic retinopathy onset in type 2 diabetes血清miR-28-5p在预测2型糖尿病视网膜病变发病中的作用DOI: 10.1186/s12902-026-02272-4
Sichuan Daxue xuebao. Yixue banVolume 57, Issue 2No.74[A Study on the Relationship Between Cyclic Inflammatory Protein Fibroblast Growth Factor 21, Osteoporosis, and Fractures]循环炎症蛋白成纤维细胞生长因子21与骨质疏松症及骨折关系的研究DOI: 10.12182/20260360107
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BMC public health IF: 03.600Ahead of Print.No.05Salt intake among adults in Kuwait: a nationally representative study using 24-hour urinary sodium excretion科威特成年人盐摄入量：基于24小时尿钠排泄的全国代表性研究DOI: 10.1186/s12889-026-27506-x
Cell communication and signaling IF: 08.900Ahead of Print.No.06H19 inhibition orchestrates DNMT3B-dependent epigenetic reprogramming of glycolytic enzymes in the liver during diabetesH19抑制在糖尿病期间协调肝脏中糖酵解酶的DNMT3B依赖性表观遗传重编程DOI: 10.1186/s12964-026-02892-2
Hormones IF: 02.500Ahead of Print.No.07Artificial intelligence vs human opportunistic detection of vertebral fractures in routine CT scans: results of a pilot study人工智能与人类在常规CT扫描中机会性检测椎体骨折的比较：一项初步研究结果DOI: 10.1007/s42000-026-00784-1
Cell Mol Life Sci IF: 06.200Ahead of Print.No.08Spatial regulation of Lck activation at the CD8 immune synapse revealed by a FRET-Based biosensor基于FRET生物传感器揭示CD8免疫突触中Lck激活的空间调控DOI: 10.1007/s00018-026-06209-x
Nature metabolism IF: 20.800Ahead of Print.No.09The diversity and consistency of what and when people eat人们饮食内容与时间的多样性和一致性DOI: 10.1038/s42255-026-01504-0
CVIR IF: 02.900Ahead of Print.No.10Endovascular Treatment of Infrapopliteal Arterial Disease in Patients with Diabetic Foot Ulcer: A Systematic Review of Randomised Controlled Trials糖尿病足溃疡患者膝下动脉疾病血管内治疗：随机对照试验的系统评价DOI: 10.1007/s00270-026-04436-0
Pharmacogenomics journal IF: 02.900Volume 26, Issue 3No.11A randomized trial to evaluate attitudes regarding pharmacogenomics among pregnant and pediatric populations: design and baseline characteristics评估孕妇和儿童群体对药物基因组学态度的随机试验：设计与基线特征DOI: 10.1038/s41397-026-00413-5
Clinica chimica acta IF: 02.900Ahead of Print.No.12Defining age partitions for thyrotropin (TSH) reference intervals in infancy: a robust statistical approach婴儿促甲状腺激素参考区间年龄分段的定义：一种稳健的统计方法DOI: 10.1016/j.cca.2026.121030
Am J Kidney Dis IF: 08.200Ahead of Print.No.13Allocation of Kidney Allografts From Donors With Kidney Donor Profile Index <35% and the Impact of Kidney Donor Profile Index Revisions on Access to Transplantation for Children供肾者肾供体特征指数<35%的肾脏移植分配及肾供体特征指数修订对儿童移植机会的影响DOI: 10.1053/j.ajkd.2026.02.643
Int J Biol Macromol IF: 08.500Ahead of Print.No.14Deep eutectic solvent-based extraction of honeybee venom proteins: A green strategy for enhanced recovery and bioactivity基于低共熔溶剂的蜜蜂毒液蛋白提取：一种增强回收率和生物活性的绿色策略DOI: 10.1016/j.ijbiomac.2026.152159
Free radical biology & medicine IF: 08.200Ahead of Print.No.15Diet-Induced Hepatic and Mitochondrial Lipid Remodeling Engages One-Carbon Metabolism Under Preserved Mitochondrial Function饮食诱导的肝脏和线粒体脂质重塑在保持线粒体功能的情况下涉及一碳代谢DOI: 10.1016/j.freeradbiomed.2026.04.031
Am J Prev Med IF: 04.500Ahead of Print.No.16Testing for Lipid Levels and Diabetes among Autistic Youth who are and are not Prescribed Anti-Psychotics: A Cohort Study自闭症青少年中接受与未接受抗精神病药物治疗者的血脂和糖尿病检测情况：一项队列研究DOI: 10.1016/j.amepre.2026.108389
Journal of affective disorders IF: 04.900Ahead of Print.No.17Do prenatal affective symptoms have an impact on the infant oral microbial exposure? Results from the Kuopio Birth Cohort Study产前情感症状是否影响婴儿口腔微生物暴露？库奥皮奥出生队列研究结果DOI: 10.1016/j.jad.2026.121828
Journal of cystic fibrosis IF: 06.000Ahead of Print.No.18Machine learning analysis of continuous glucose monitoring identifies a novel dysglycemic phenotype found in most people with cystic fibrosis机器学习分析持续葡萄糖监测发现大多数囊性纤维化患者存在一种新型血糖异常表型DOI: 10.1016/j.jcf.2026.04.001
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.19New lipid-lowering drugs on the horizon. A range of possibilities新型降脂药物即将问世：多种可能性DOI: 10.1016/j.endien.2026.501807
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.20Web-based application for the interpretation of adrenal vein sampling results基于网络的肾上腺静脉采血结果解读应用程序DOI: 10.1016/j.endien.2026.501723
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.21Sternoclavicular osteomyelitis and secondary mediastinitis in patients with diabetes: A case series from a Mexican tertiary referral center糖尿病患者胸锁关节骨髓炎继发纵隔炎：墨西哥某三级转诊中心病例系列DOI: 10.1016/j.endien.2026.501712
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.22The Landscape of Pediatric Differentiated Thyroid Carcinoma and Predictors of Invasive Disease: A CATC Study儿童分化型甲状腺癌的现状及侵袭性疾病的预测因素：一项CATC研究DOI: 10.1210/clinem/dgag172
The Journal of surgical research IF: 01.700Ahead of Print.No.23Extending the Observational Medical Outcomes Partnership Common Data Model to Support Observational Peripheral Vascular Disease Research扩展观察性医疗结果合作伙伴通用数据模型以支持观察性外周血管疾病研究DOI: 10.1016/j.jss.2026.03.089
The Journal of surgical research IF: 01.700Ahead of Print.No.24Identifying Factors Associated With Postdischarge Mortality After Readmission Following Pancreaticoduodenectomy胰十二指肠切除术后再入院患者出院后死亡相关因素分析DOI: 10.1016/j.jss.2026.03.109
Environment international IF: 09.700Ahead of Print.No.25Prenatal exposure to particulate matter impairs offspring behavior via hippocampal NMDA receptor reduction: an in vivo and ex vivo study产前颗粒物暴露通过海马NMDA受体减少损害子代行为：体内和体外研究DOI: 10.1016/j.envint.2026.110270
J Obstet Gynaecol Can IF: 02.200Ahead of Print.No.26Prevalence of Iron Deficiency and Anemia in Pregnancy in a Canadian Cohort and Definition of Normal Hemoglobin Ranges in Iron Replete Women加拿大妊娠期缺铁和贫血患病率及铁充足女性正常血红蛋白范围的定义DOI: 10.1016/j.jogc.2026.103370
Fundam Clin Pharmacol IF: 02.500Volume 40, Issue 3No.27Alogliptin Delays the Healing of Traumatic Oral Ulcers in the Buccal Mucosa of Wistar Rats阿格列汀延迟Wistar大鼠颊黏膜创伤性口腔溃疡愈合DOI: 10.1111/fcp.70090
Acta medica Okayama IF: 00.600Volume 80, Issue 2No.28Effects of Nonsurgical Periodontal Treatment on Bacterial and Clinical Parameters in Down Syndrome Patients Based on 16S rRNA Gene Amplicon Sequencing基于16S rRNA基因扩增子测序的非手术牙周治疗对唐氏综合征患者细菌和临床参数的影响DOI: 10.18926/AMO/70451
Nature communications IF: 15.700Ahead of Print.No.29MicroRNA-30c analog C2 decreases plasma cholesterol and atherosclerosis without causing liver injury in preclinical studiesMicroRNA-30c类似物C2在临床前研究中降低血浆胆固醇和动脉粥样硬化且不引起肝损伤DOI: 10.1038/s41467-026-72276-0
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.30Assessment of arterial stiffness and plasma FGF23 levels in patients with hypoparathyroidism甲状旁腺功能减退症患者动脉僵硬度与血浆FGF23水平的评估DOI: 10.1016/j.endien.2026.501724
Am J Kidney Dis IF: 08.200Ahead of Print.No.31Association of Ertugliflozin on Kidney Outcomes in People After and Without an Interval Cardiovascular Event: Observations From the VERTIS CV Trial厄格列净对有无心血管事件间隔人群肾脏结局的影响：VERTIS CV试验观察DOI: 10.1053/j.ajkd.2026.01.017
Comput Biol Chem IF: 03.100Ahead of Print.No.32Structure-activity relationship-guided design of carbazole-thiazole hybrids as α-glucosidase inhibitors: DFT analysis, molecular modelling, ADMET prediction and in vivo validation基于构效关系指导的咔唑-噻唑杂合物作为α-葡萄糖苷酶抑制剂的设计：DFT分析、分子建模、ADMET预测及体内验证DOI: 10.1016/j.compbiolchem.2026.109077
J Am Pharm Assoc (2003)Ahead of Print.No.33Impact of a charitable medication program and social vulnerability index on clinical outcomes in uninsured adults with diabetes慈善药物项目和社会脆弱性指数对无保险成人糖尿病患者临床结局的影响DOI: 10.1016/j.japh.2026.103116
J Pharmacol Sci IF: 02.900Volume 161, Issue 2No.34Myricetin inhibits vascular calcification in an in vitro model by modulating ferroptosis-related SLC7A11/GPX4 signaling杨梅素通过调节铁死亡相关SLC7A11/GPX4信号通路抑制体外血管钙化DOI: 10.1016/j.jphs.2026.03.003
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.35Vitamin D deficiency and depression in diabetes mellitus: A systematic review and meta-analysis糖尿病中维生素D缺乏与抑郁：系统综述和荟萃分析DOI: 10.1016/j.endien.2026.501743
Obesity IF: 04.700Ahead of Print.No.36Corrigendum to "Nutritional Priorities to Support GLP-1 Therapy for Obesity: A Joint Advisory From the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society"《支持GLP-1治疗肥胖的营养优先事项：美国生活方式医学学会、美国营养学会、肥胖医学协会和肥胖学会的联合建议》勘误DOI: 10.1002/oby.70222
BMC surgery IF: 01.800Ahead of Print.No.37Impact of laparoscopic sleeve gastrectomy on obesity-related comorbidities in patients over 65 years: a prospective comparative study腹腔镜袖状胃切除术对65岁以上患者肥胖相关合并症的影响：一项前瞻性比较研究DOI: 10.1186/s12893-026-03707-4
Nutrition IF: 03.000Ahead of Print.No.38Investigating the relationship between nutrient intake patterns and obesity indices among Jordanians约旦人群营养素摄入模式与肥胖指标关系的研究DOI: 10.1016/j.nut.2026.113216
Obesity surgery IF: 03.100Ahead of Print.No.39Sequential Intragastric Balloon Followed By GLP-1 Receptor Agonist Therapy in Obesity: A Comparative Study of 12-Month Weight Loss Outcomes序贯胃内球囊联合GLP-1受体激动剂治疗肥胖症：12个月减重效果的比较研究DOI: 10.1007/s11695-026-08698-y
Indian J Gastroenterol IF: 02.100Ahead of Print.No.40The 'Obesity First' approach: Redefining the future of healthcare-An opinion“肥胖优先”策略：重新定义医疗保健的未来——一种观点DOI: 10.1007/s12664-026-02000-9
Neuropsychopharmacology IF: 07.100Ahead of Print.No.41Adolescent obesity induces sex-specific alterations of action control青少年肥胖导致行动控制的性别特异性改变DOI: 10.1038/s41386-026-02419-w
Nature medicine IF: 50.000Ahead of Print.No.42Genetics and GLP-1 drug responses遗传学与GLP-1药物反应DOI: 10.1038/d41591-026-00022-6
Nature genetics IF: 29.000Ahead of Print.No.43Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome基因组分析揭示多囊卵巢综合征中的激素和代谢失调DOI: 10.1038/s41588-026-02543-9
Communications medicine IF: 06.300Ahead of Print.No.44Cross-organ MRI to assess the relationship between cardiac traits and cerebral white matter hyperintensity volumes跨器官磁共振成像评估心脏特征与脑白质高信号体积的关系DOI: 10.1038/s43856-026-01604-8
Am J Med Sci IF: 01.800Ahead of Print.No.45Comments on 'Effect of therapeutic lifestyle changes on patients with overweight/obesity and non-alcoholic fatty liver disease: A randomized controlled trial'对《治疗性生活方式改变对超重/肥胖合并非酒精性脂肪性肝病患者的影响：一项随机对照试验》的评论DOI: 10.1016/j.amjms.2026.04.007
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.46Online surveys, a breakthrough in research, especially in nutrition and food sciences在线调查：研究领域的突破，尤其在营养与食品科学中DOI: 10.1016/j.clnesp.2026.103299
Clinical nutrition ESPEN IF: 02.600Ahead of Print.No.47Nutritional surveillance and diet adherence in pediatric celiac disease: a multidisciplinary case-control study within a clinical nutrition model儿童乳糜泻的营养监测与饮食依从性：临床营养模型中的多学科病例对照研究DOI: 10.1016/j.clnesp.2026.103298
Journal of renal nutrition : IF: 03.200Ahead of Print.No.48Association between body mass index and survival in individuals on hemodialysis体重指数与血液透析患者生存率之间的关联DOI: 10.1053/j.jrn.2026.04.008
Molecular metabolism IF: 06.600Ahead of Print.No.49A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion迷走神经-β细胞神经回路感知葡萄糖并调节胰岛素分泌DOI: 10.1016/j.molmet.2026.102371
Value in health IF: 06.000Ahead of Print.No.50Patient Preferences, Perceptions, and Influencing Factors in Weight Loss Pharmacotherapy and Bariatric Surgery: A Systematic Literature Review减重药物疗法与减重手术中的患者偏好、认知及影响因素：一项系统文献综述DOI: 10.1016/j.jval.2026.04.001
Medical care IF: 02.800Ahead of Print.No.51Diabetes Diagnosis Patterns in Medicaid: How State Policy, Managed Care, and Social Vulnerability Shape Detection in Medicaid医疗补助计划中的糖尿病诊断模式：州政策、管理式医疗和社会脆弱性如何影响检测DOI: 10.1097/MLR.0000000000002328
Infection, disease & health IF: 02.000Ahead of Print.No.52Surgical site infection following caesarean section: Incidence and healthcare resource utilisation in a tertiary mother and children hospital in Malaysia剖宫产术后手术部位感染：马来西亚一家三级妇幼医院的发病率和医疗资源利用情况DOI: 10.1016/j.idh.2026.100423
World J Surg Oncol IF: 02.500Ahead of Print.No.53Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort术前胰岛素抵抗替代指标与结直肠癌切除术后吻合口漏风险的相关性：一项多中心回顾性队列研究DOI: 10.1186/s12957-026-04367-7
J Mol Graph Model IF: 03.000Ahead of Print.No.54Unveiling the mechanism of action of Cymarin in combating breast cancer: An integrated computational analysis揭示西马林抗乳腺癌的作用机制：一项综合计算分析DOI: 10.1016/j.jmgm.2026.109416
Hormones IF: 02.500Ahead of Print.No.55Fasting safely during Ramadan with diabetes: clinical practice recommendations for Arab populations from the Arab Diabetes Forum (FSR-ADF)糖尿病患者斋月期间安全禁食：阿拉伯糖尿病论坛针对阿拉伯人群的临床实践建议（FSR-ADF）DOI: 10.1007/s42000-026-00783-2
The veterinary journal IF: 03.100Ahead of Print.No.56Effects of vatinoxan in horses sedated with detomidine and butorphanol for gastroscopy: a randomized clinical study瓦替诺生在右美托咪定和布托啡诺镇静马匹进行胃镜检查中的作用：一项随机临床研究DOI: 10.1016/j.tvjl.2026.106680
Molecular metabolism IF: 06.600Ahead of Print.No.57Systems Genetics Reveals ITIH5 as a Key Mediator of Adipocyte-Endothelial Crosstalk系统遗传学揭示ITIH5是脂肪细胞-内皮细胞串扰的关键介质DOI: 10.1016/j.molmet.2026.102373
Am J Prev Med IF: 04.500Ahead of Print.No.58Persistent sex differences in cardiovascular disease risk factors: a longitudinal cohort study in youth with type 1 diabetes心血管疾病危险因素的持续性性别差异：一项针对1型糖尿病青少年的纵向队列研究DOI: 10.1016/j.amepre.2026.108391
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.59Psychopathological aspects of EDs in adolescents with type 1 diabetes: Findings from the DEPS-R and clinical outcomes1型糖尿病青少年进食障碍的精神病理学方面：来自DEPS-R和临床结局的发现DOI: 10.1016/j.endien.2026.501719
Endocrinol Diabetes Nutr (Engl Ed) IF: 01.800Volume 73, Issue 4No.60Myostatin in the pituitary-muscle axis: Roles in health and disease垂体-肌肉轴中的肌生成抑制素：在健康和疾病中的作用DOI: 10.1016/j.endien.2026.501757
Cardiovascular Research IF: 13.300Ahead of Print.No.61Integrated left ventricular multi-omics landscape of human cardiometabolic HFpEF人类心脏代谢性射血分数保留的心力衰竭的左心室多组学整合景观DOI: 10.1093/cvr/cvag084
Cell metabolism IF: 30.900Ahead of Print.No.62Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary proteinCav3.1是一种神经元亮氨酸传感器，介导膳食蛋白质引起的饱腹感和体重减轻DOI: 10.1016/j.cmet.2026.03.017
Cardiovasc Diabetol Endocrinol RepVolume 12, Issue 1No.63Efficacy and safety of semaglutide injection in Indian patients with type 2 diabetes mellitus inadequately controlled on metformin: a phase 3, randomized, active-controlled trial (SIZE-DM study)司美格鲁肽注射液在二甲双胍控制不佳的印度2型糖尿病患者中的有效性和安全性：一项3期、随机、活性对照试验（SIZE-DM研究）DOI: 10.1186/s40842-026-00290-8
J Am Pharm Assoc (2003)Ahead of Print.No.64Semaglutide for obesity management: A narrative review of efficacy, safety, and future directions司美格鲁肽用于肥胖管理：有效性、安全性和未来方向的叙述性综述DOI: 10.1016/j.japh.2026.103117
Am J Ophthalmol IF: 04.200Ahead of Print.No.65Glucagon-Like Peptide-1 Receptor Agonists and Risk of Systemic and Ocular Vascular Complications in Patients with Type 2 Diabetes and Diabetic Retinopathy胰高血糖素样肽-1受体激动剂与2型糖尿病合并糖尿病视网膜病变患者全身及眼部血管并发症风险DOI: 10.1016/j.ajo.2026.04.021
Acta Physiologica IF: 05.600Volume 242actaphysiologica, Issue 5, Page e70213-e70215No.66Adhesion GPCRs as Hot Targets for Obesity黏附G蛋白偶联受体成为肥胖治疗的热门靶点DOI: 10.1111/apha.70225
Am J Prev Cardiol IF: 05.900Ahead of Print.No.67Body Mass Index, Waist-to-Height Ratio, and the Risks of Premature Heart Failure in Adults Age Under 45体重指数、腰围身高比与45岁以下成年人早发性心力衰竭的风险DOI: 10.1016/j.ajpc.2026.101650
The Lancet IF: 88.500Volume 407, Issue 10539, Page 1573-1656No.68Semaglutide, weight loss, and cardiovascular outcomes in the SELECT trial – Authors' replySELECT试验中司美格鲁肽、减重与心血管结局——作者回复DOI: 10.1016/S0140-6736(26)00706-3
Indian J Med Res IF: 02.500Volume 163, Issue 3No.69Association of GCKR and GLIS3 gene polymorphisms with gestational diabetes mellitus: A case-control studyGCKR和GLIS3基因多态性与妊娠期糖尿病的关联：一项病例对照研究https://pubmed.ncbi.nlm.nih.gov/42024906
JMIR diabetes IF: 02.600Volume 11, Issue No.70The Process of Developing an Intervention to Increase Awareness of Cardiovascular Risk for Persons With Type 2 Diabetes: Co-Creation Study为2型糖尿病患者开发提高心血管风险意识干预措施的过程：共创研究DOI: 10.2196/85748
Physiother Res Int IF: 01.800Volume 31, Issue 2No.71Measurement Properties of the Modified Incremental Step Test for Assessing Exercise Capacity in Individuals With Type 2 Diabetes改良递增台阶试验评估2型糖尿病患者运动能力的测量特性DOI: 10.1002/pri.70224
ACS applied bio materials IF: 04.700Ahead of Print.No.72Engineering MoS(2)/CoSe(2) Hybrid Nanocomposites for Efficient Regeneration of Bacterially Infected Diabetic Wounds工程化MoS₂/CoSe₂杂化纳米复合材料用于细菌感染糖尿病伤口的高效再生DOI: 10.1021/acsabm.5c02244
Ophthalmic Plast Reconstr Surg IF: 01.300Ahead of Print.No.73Is Cataract Surgery a Risk Factor for New-Onset Thyroid Eye Disease?白内障手术是新发甲状腺眼病的危险因素吗？DOI: 10.1097/IOP.0000000000003218
JCI insight IF: 06.100Ahead of Print.No.74Preservation of pancreatic endocrine and peri-islet exocrine capillary networks in type 2 diabetes2型糖尿病中胰腺内分泌和胰岛周围外分泌毛细血管网络的保留DOI: 10.1172/jci.insight.202118
J Clin Invest IF: 13.600Ahead of Print.No.75The N-terminus of Apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells载脂蛋白B的N端介导致动脉粥样硬化脂蛋白与内皮细胞的相互作用DOI: 10.1172/JCI190513
Obstetrics and Gynecology IF: 04.700Ahead of Print.No.76Screening for Cervical Cancer: A Recommendation From the Women's Preventive Services Initiative宫颈癌筛查：妇女预防服务倡议的建议DOI: 10.1097/AOG.0000000000006315
Can J Diet Pract Res IF: 00.700Ahead of Print.No.77School Nutrition Education in Canada: Call to Action for Dietitians to Advocate for Social Justice加拿大学校营养教育：呼吁营养师倡导社会正义DOI: 10.3148/cjdpr-2026-001
Science IF: 45.800Ahead of Print.No.78Severe obesity in human HFpEF alters contractile protein function and organization人类射血分数保留的心力衰竭中严重肥胖改变收缩蛋白功能和组织DOI: 10.1126/science.adz7118
Revista médica de Chile IF: 00.300Volume 154, Issue 2No.79[Obesity in Chile: A Worrying Future]智利肥胖问题：令人担忧的未来DOI: 10.4067/s0034-98872026000200288
Revista médica de Chile IF: 00.300Volume 154, Issue 2No.80[Pharmacological Activation of ERRα/β/γ as an Exercise Mimetic: Potential Therapeutic Applications]ERRα/β/γ的药理学激活作为运动模拟物：潜在的治疗应用DOI: 10.4067/s0034-98872026000200237
PLoS medicine IF: 09.900Volume 23, Issue 4No.81Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and mendelian randomization亚洲印度人与欧洲人中心血管代谢疾病相关脂质数量性状位点的鉴定：一项全基因组关联研究和孟德尔随机化分析DOI: 10.1371/journal.pmed.1005039
Rev Esp Cir Ortop TraumatolVolume 70, Issue 1No.82Prevalence of diabetic foot in patients with diabetes mellitus undergoing dialysis treatment in a tertiary-level hospital in Argentina阿根廷某三级医院接受透析治疗的糖尿病患者中糖尿病足的患病率DOI: 10.1016/j.recot.2025.11.012
Rev Esp Cir Ortop TraumatolVolume 70, Issue 1No.83Prevalence of diabetic foot in patients with diabetes mellitus undergoing dialysis treatment in a tertiary-level hospital in Argentina阿根廷某三级医院接受透析治疗的糖尿病患者中糖尿病足的患病率DOI: 10.1016/j.recot.2025.04.018
Heart Rhythm IF: 05.700Ahead of Print.No.84Glucagon-Like Peptide-1 and Atrial Fibrillation Incidence: Associations Independent of Weight Loss胰高血糖素样肽-1与心房颤动发生率：独立于体重减轻的关联DOI: 10.1016/j.hrthm.2026.03.1940
Journal of endocrinology IF: 03.900Ahead of Print.No.85Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity热量限制对骨骼结构和骨髓脂肪的影响具有部位、性别和持续时间依赖性DOI: 10.1530/JOE-25-0391
Pol Arch Intern Med IF: 04.700Ahead of Print.No.86Diagnostic utility of non-invasive tests for significant liver fibrosis in people with metabolic dysfunction-associated steatotic liver disease非侵入性检测在代谢功能障碍相关脂肪性肝病患者显著肝纤维化中的诊断效用DOI: 10.20452/pamw.17277
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.87Investigating the therapeutic effects of caffeine-naringenin combination on the repair of intestinal permeability and composition of gut microbiota in obese rats under long-term high-fat diet咖啡因-柚皮素组合对长期高脂饮食肥胖大鼠肠道通透性修复及肠道菌群组成的治疗作用研究DOI: 10.1007/s00210-026-05136-9
Psychiatric quarterly IF: 02.900Ahead of Print.No.88History of Cannabis Use and Obesity Among U.S. Low-Income Veterans: Associations With Mental Health and Psychosocial Functioning美国低收入退伍军人大麻使用史与肥胖：与心理健康及社会心理功能的关联DOI: 10.1007/s11126-026-10284-5
Med Sci Sports Exerc IF: 03.900Ahead of Print.No.89Combination of Intermittent Hypoxic Exposure and Exercise Improves Body Composition and Glucose Tolerance in High-Fat Diet-Induced Obese Mice间歇性低氧暴露与运动联合改善高脂饮食诱导肥胖小鼠的身体成分和葡萄糖耐量DOI: 10.1249/MSS.0000000000004015
Kathmandu Univ Med J (KUMJ)Volume 23, Issue 90No.90Double Burden of Malnutrition among Mother-Child Dyads in a Rural Area of West Bengal, India: A Comprehensive Analysis of Contributing Factors印度西孟加拉邦农村地区母子二元营养双重负担的综合分析https://pubmed.ncbi.nlm.nih.gov/42023568
Kathmandu Univ Med J (KUMJ)Volume 23, Issue 90No.91Serum Uric Acid and its Correlation with Inflammation in Hypertension, a Hospital Based Case-control Study血清尿酸与高血压炎症的相关性：一项基于医院的病例对照研究https://pubmed.ncbi.nlm.nih.gov/42023562
JAMA Network Open IF: 09.700Volume 9, Issue 4No.92Vitamin D Receptor Polymorphism-A D-Terminant for Vitamin D's Association With Risk for Type 2 Diabetes维生素D受体多态性——维生素D与2型糖尿病风险关联的决定因素DOI: 10.1001/jamanetworkopen.2026.7315
JAMA Network Open IF: 09.700Volume 9, Issue 4No.93Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes维生素D受体多态性与维生素D补充对糖尿病前期成人糖尿病风险的影响DOI: 10.1001/jamanetworkopen.2026.7332
Wounds IF: 01.100Volume 38, Issue 1No.94Reporting of social demographics in diabetic foot ulcer randomized controlled trials: a scoping review糖尿病足溃疡随机对照试验中社会人口学报告的范围综述DOI: 10.25270/wnds/25020
Hormones IF: 02.500Ahead of Print.No.95Endocrine disruptors are contributing to type 2 diabetes mellitus内分泌干扰物促进2型糖尿病的发生DOI: 10.1007/s42000-026-00779-y
Journal of proteome research IF: 03.600Ahead of Print.No.96Machine Learning Analysis of Serum Metabolomics for Multi-Disease Classification and Proteome-Metabolome Pathway Insights in T2D, IBD, and CRC基于机器学习分析血清代谢组学用于T2D、IBD和CRC的多疾病分类及蛋白质组-代谢组通路洞察DOI: 10.1021/acs.jproteome.5c01212
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.97Larger baseline body stature predicts one-year amyloid change in cognitively normal older adults enriched with elevated amyloid status较大基线体型预测认知正常且淀粉样蛋白水平升高的老年人一年内淀粉样蛋白变化DOI: 10.1177/13872877261445598
Rev Esp Cir Ortop TraumatolVolume 69, Issue 6No.98[Translated article] Gender and diabetes mellitus do not influence the outcomes of patients with proximal humeral fractures treated with a reverse shoulder arthroplasty性别和糖尿病不影响接受反向肩关节置换术的肱骨近端骨折患者的预后DOI: 10.1016/j.recot.2025.07.012
Liver transplantation : IF: 03.900Ahead of Print.No.99Multi-modal machine learning highlights recipient genetic and clinical factors as primary drivers of post-transplant MASLD: A two-center study多模态机器学习揭示受者遗传和临床因素是移植后代谢相关脂肪性肝病的主要驱动因素：一项两中心研究DOI: 10.1097/LVT.0000000000000881
Nutrición hospitalaria IF: 01.100Ahead of Print.No.100Associations of C-reactive protein-triglyceride-glucose index cumulative burden with incident cardiovascular disease in middle-aged and older Chinese adults with abnormal glucose metabolismC反应蛋白-甘油三酯-葡萄糖指数累积负担与中老年糖代谢异常中国成人新发心血管疾病的关联DOI: 10.20960/nh.06533
J Diabetes Investig IF: 03.000Ahead of Print.No.101A review of capillary β-hydroxybutyrate cut-off levels for the exclusion and identification of diabetic ketoacidosis毛细血管β-羟基丁酸截断值用于排除和识别糖尿病酮症酸中毒的综述DOI: 10.1111/jdi.70317
Alzheimer's & dementia IF: 11.100Volume 22, Issue 4No.102Diabetes, hyperglycemia, and ATN blood biomarkers in Hispanic/Latino populations: SOL-INCA study糖尿病、高血糖与西班牙裔/拉丁裔人群ATN血液生物标志物的关联：SOL-INCA研究DOI: 10.1002/alz.71223
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.103Dysmorphic syndromes with overgrowth - systematic review, part 2: chromosomal and epigenetic disorders and disorders associated with dynamic mutations伴有过度生长的畸形综合征——系统综述第二部分：染色体和表观遗传疾病以及与动态突变相关的疾病DOI: 10.5114/pedm.2026.159968
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.104Determination of a higher hypoglycemic threshold in the insulin tolerance test for children with short stature矮身材儿童胰岛素耐量试验中更高低血糖阈值的确定DOI: 10.5114/pedm.2026.159674
BJOG IF: 04.700Ahead of Print.No.105Pre-Pregnancy Body Mass Index, Diabetes Status, and Gestational Age-Specific Stillbirth Risk: A Nationwide Retrospective Cohort Study孕前体重指数、糖尿病状态与孕周特异性死产风险：一项全国性回顾性队列研究DOI: 10.1111/1471-0528.70247
Endocrine connections IF: 02.800Ahead of Print.No.106Factors affecting the quality of life of adults living with Congenital Adrenal Hyperplasia: A qualitative study of lived experience影响先天性肾上腺皮质增生症成人患者生活质量的因素：一项关于生活体验的定性研究DOI: 10.1530/EC-26-0033
Rev Esp Cir Ortop TraumatolAhead of Print.No.107[Not Available]腰椎后路融合术后急性感染的危险因素分析DOI: 10.1016/j.recot.2026.03.008
JAMA ophthalmology IF: 09.200Ahead of Print.No.108Brolucizumab in the Treatment of Proliferative Diabetic Retinopathy: The CONDOR Randomized Clinical TrialBrolucizumab治疗增殖性糖尿病视网膜病变：CONDOR随机临床试验DOI: 10.1001/jamaophthalmol.2026.1008
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.109Association between bone health and cardiovascular events in a population-based cohort基于人群的队列研究中骨骼健康与心血管事件之间的关联DOI: 10.1007/s11657-026-01704-x
Rev Esp Cir Ortop TraumatolVolume 69, Issue 6No.110Clinical outcomes of closuring technique in total hip arthroplasty and total knee arthroplasty: A comparative study of staples technique vs triclosan-coated barbed sutures全髋关节置换术和全膝关节置换术中闭合技术的临床结果：钉合技术与三氯生涂层倒刺缝线的比较研究DOI: 10.1016/j.recot.2025.07.010
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.111Graves' disease and autoimmune hepatitis overlap syndrome with coincidental simultaneous presentation in a pediatric patient儿童患者格雷夫斯病与自身免疫性肝炎重叠综合征的偶然同时出现DOI: 10.5114/pedm.2026.160225
Otolaryngologia Polska IF: 00.600Volume 80, Issue 2No.112Management of COVID associated invasive fungal sinusitisCOVID相关侵袭性真菌性鼻窦炎的管理DOI: 10.5604/01.3001.0055.6613
Pediatr Endocrinol Diabetes MetabVolume 32, Issue 1No.113Ketoacidosis in new-onset type 1 diabetes: return to pre-COVID-19 pandemic reality?新发1型糖尿病酮症酸中毒：回归COVID-19大流行前现实？DOI: 10.5114/pedm.2026.159708
The Lancet Digital Health IF: 24.100Ahead of Print.No.114Detection of young-onset type 2 diabetes using deep learning across primary and secondary care: a nationwide, retrospective cohort study利用深度学习在初级和二级医疗中检测青少年起病的成人型糖尿病：一项全国性回顾性队列研究DOI: 10.1016/j.landig.2025.100968
JMCC IF: 04.700Ahead of Print.No.115Pathophysiology and pharmacotherapy of cardiovascular complications in metabolic syndrome代谢综合征心血管并发症的病理生理学与药物治疗DOI: 10.1016/j.yjmcc.2026.04.007
JGH open : IF: 01.500Volume 10, Issue 3No.116Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Patients With Inflammatory Bowel Disease: A Real-World Comparison of Combination Therapy Versus Monotherapy炎症性肠病患者抗肿瘤坏死因子α治疗有效性丧失：联合治疗与单药治疗的真实世界比较DOI: 10.1002/jgh3.70385
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 3No.117Frequency and comorbidities of age-related macular degeneration in KSA: A retrospective multiregional study沙特阿拉伯年龄相关性黄斑变性的频率与合并症：一项多区域回顾性研究DOI: 10.1016/j.jtumed.2026.03.009
Curēus IF: 01.300Volume 18, Issue 3No.118Assessment of Outcomes of Endonasal Dacryocystorhinostomy in a Tertiary Referral Center三级转诊中心鼻内镜下泪囊鼻腔吻合术的疗效评估DOI: 10.7759/cureus.105621
Health science reports IF: 02.100Volume 9, Issue 3No.119Optimal Wound pH and Related Factors in the Healing Process of Diabetes-Related Foot Ulcer: A Prospective Observational Study糖尿病相关足溃疡愈合过程中的最佳伤口pH值及相关因素：一项前瞻性观察性研究DOI: 10.1002/hsr2.72079
Health science reports IF: 02.100Volume 9, Issue 3No.120Associations Between the Severity of Obstructive Sleep Apnea and Arterial Stiffness Estimated by Pulse Wave Velocity Assessment: A Cross-Sectional Study阻塞性睡眠呼吸暂停严重程度与脉搏波速度评估的动脉僵硬度之间的关联：一项横断面研究DOI: 10.1002/hsr2.71861
Health science reports IF: 02.100Volume 9, Issue 3No.121Assessment of Quality of Care Provided for Patients Receiving Post-Myocardial Infarction Care at Selected Cardiac Clinics in Sulaymaniyah: Cross-Sectional Study苏莱曼尼亚选定心脏诊所心肌梗死后患者护理质量评估：横断面研究DOI: 10.1002/hsr2.72099
Chronic Dis Transl MedVolume 12, Issue 1No.122Self-Management Interventions in Young Adults (18-30 Years) With Type 1 Diabetes, Sickle Cell Disease, and Inflammatory Bowel Disease: A Scoping Review年轻成人（18-30岁）1型糖尿病、镰状细胞病和炎症性肠病自我管理干预的范围综述DOI: 10.1002/cdt3.70032
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.123Barriers to prescribing and insurance approval of SGLT2 inhibitors for heart failure: a mixed-methods study in Jordan约旦心力衰竭患者处方和保险审批中使用钠-葡萄糖协同转运蛋白2抑制剂的障碍：一项混合方法研究DOI: 10.3389/fphar.2026.1803731
JCEM case reportsVolume 4, Issue 5No.124Ultra-rapid prolactin normalization with cabergoline in a premenopausal woman with epilepsy and giant prolactinoma卡麦角林在绝经前女性癫痫合并巨大泌乳素瘤患者中实现泌乳素超快速正常化DOI: 10.1210/jcemcr/luag105
Public health challengesVolume 5, Issue No.125Determinants of Health-Seeking Behavior and Quality of Life in Patients With Noncommunicable Diseases in Bangladesh孟加拉国非传染性疾病患者健康寻求行为与生活质量的决定因素DOI: 10.1002/puh2.70238
Clinical nephrology IF: 01.000Ahead of Print.No.126Impact of different A1c targets on cardiovascular outcomes in diabetic kidney transplant recipients: A global cohort analysis不同A1c目标对糖尿病肾移植受者心血管结局的影响：一项全球队列分析DOI: 10.5414/CN111994
Gut and liver IF: 03.200Ahead of Print.No.127The Chronic Hepatitis B and Metabolic Dysfunction-Associated Steatotic Liver Disease Paradox: Friend or Foe?慢性乙型肝炎与代谢功能障碍相关脂肪性肝病的悖论：朋友还是敌人？DOI: 10.5009/gnl250444
Epidemiologia e prevenzione IF: 01.500Volume 50, Issue 2No.128Diabetes, disease management, and risk of mortality by immigrant status: a population-based cohort study in Reggio Emilia Province (Northern Italy)糖尿病、疾病管理与移民状态下的死亡风险：意大利雷焦艾米利亚省一项基于人群的队列研究DOI: 10.19191/EP26.2.A1018.033
LUTS IF: 01.500Volume 18, Issue 3No.129Rates and Predictors of Persistent LUTS Medication Use After Laser Enucleation of the Prostate前列腺激光剜除术后持续使用下尿路症状药物的比率及预测因素DOI: 10.1111/luts.70062
Proc Inst Mech Eng H IF: 01.500Ahead of Print.No.130Finite element framework for investigating the mechanical response of podiatric insole: A pilot study足部矫形鞋垫力学响应研究的有限元框架：一项初步研究DOI: 10.1177/09544119261434625
Respirology case reports IF: 00.800Volume 14, Issue 3No.131IgG4-Related Lung Disease in a Former Smoker: A Challenging Diagnosis一例既往吸烟者中的IgG4相关性肺病：具有挑战性的诊断DOI: 10.1002/rcr2.70538
Frontiers in aging IF: 04.300Volume 7, Issue No.132Therapeutic peptides in gerontology: mechanisms and applications for healthy aging老年学中的治疗性肽：健康衰老的机制与应用DOI: 10.3389/fragi.2026.1790247
Health science reports IF: 02.100Volume 9, Issue 4No.133Different SARS-CoV-2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD)不同SARS-CoV-2亚型与凝血标志物趋势：来自伊朗病毒性疾病研究网络的回顾性多中心研究DOI: 10.1002/hsr2.72390
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.134Bone mineral density in children and adolescents with type 1 diabetes: A case-control study from South India1型糖尿病儿童和青少年骨密度：来自南印度的病例对照研究DOI: 10.4103/jfmpc.jfmpc_1637_24
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.135Screening practices and risk factors for diabetic foot complications among patients with diabetes at a tertiary centre in Riyadh, Saudi Arabia沙特阿拉伯利雅得一家三级医院糖尿病患者糖尿病足并发症的筛查实践与风险因素DOI: 10.4103/jfmpc.jfmpc_1899_25
Med J Islam Repub IranVolume 39, Issue No.136Plasma sFRP4 Levels and Their Relationship with HOMA IR in Women with Gestational Diabetes Mellitus妊娠期糖尿病女性血浆sFRP4水平及其与HOMA-IR的关系DOI: 10.47176/mjiri.39.129
J Reprod Infant Psychol IF: 01.600Ahead of Print.No.137Breastfeeding, gestational diabetes and maternal distress in Iran: findings from the PERSIAN cohort伊朗母乳喂养、妊娠期糖尿病与产妇心理困扰：PERSIAN队列研究结果DOI: 10.1080/02646838.2026.2662667
International health IF: 02.200Ahead of Print.No.138Feasibility and outcomes of diabetes mellitus screening in people with tuberculosis in Burundi布隆迪结核病患者糖尿病筛查的可行性与结果DOI: 10.1093/inthealth/ihag036
Immunology and cell biology IF: 03.000Ahead of Print.No.139Appetite for destruction: dietary lipids tune the ferroptotic threshold of adaptive immunity破坏的欲望：膳食脂质调节适应性免疫的铁死亡阈值DOI: 10.1111/imcb.70119
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.140A study on assessment of risk factors for non-communicable diseases in adopted families under family adoption programme - A community - based cross-sectional study家庭收养计划下收养家庭非传染性疾病危险因素评估研究——一项基于社区的横断面研究DOI: 10.4103/jfmpc.jfmpc_836_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.141Hemostatic imbalances in chronic kidney disease: A regional perspective from Bihar慢性肾脏病中的止血失衡：来自比哈尔邦的区域视角DOI: 10.4103/jfmpc.jfmpc_830_25
Health science reports IF: 02.100Volume 9, Issue 4No.142Adult Women's Height and Non-Communicable Disease Risk in Sub-Saharan Africa: A Cross-Sectional Analysis of Demographic and Health Surveys撒哈拉以南非洲成年女性身高与非传染性疾病风险：基于人口与健康调查的横断面分析DOI: 10.1002/hsr2.72413
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.143Editorial: Endocrine regulation of homeostasis of water, electrolytes and organic solutes社论：水、电解质和有机溶质稳态的内分泌调节DOI: 10.3389/fendo.2026.1826713
JID innovationsVolume 6, Issue 3No.144Local IgG autoantibody profiles in hidradenitis suppurativa and their associations with disease features and anti-TNF therapy化脓性汗腺炎局部IgG自身抗体谱及其与疾病特征和抗TNF治疗的关系DOI: 10.1016/j.xjidi.2026.100467
Respirology case reports IF: 00.800Volume 14, Issue 3No.145Sodium Glucose-Like Co-Transporter 2 Inhibitor (SGLT2i) Use in Adults With Cystic Fibrosis钠-葡萄糖协同转运蛋白2抑制剂在成人囊性纤维化中的应用DOI: 10.1002/rcr2.70533
JCEM case reportsVolume 4, Issue 5No.146Complete glucocorticoid resistance: a lethal disorder in the neonatal period完全性糖皮质激素抵抗：新生儿期致死性疾病DOI: 10.1210/jcemcr/luag079
Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.147Inflammation-Autonomic Crosstalk Contributes to Left Ventricular Diastolic Dysfunction in Type 2 Diabetes: A Rationale for Neuromodulation炎症-自主神经串扰在2型糖尿病左心室舒张功能障碍中的作用：神经调控的理论基础DOI: 10.1152/ajpheart.01006.2025
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.148SCORE2-diabetes vs SCORE for evaluation of cardiovascular risk in diabetic patientsSCORE2-糖尿病与SCORE在糖尿病患者心血管风险评估中的比较DOI: 10.4103/jfmpc.jfmpc_663_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.149Saudi family physician's clinical inertia of type 2 diabetes management沙特家庭医生在2型糖尿病管理中的临床惰性DOI: 10.4103/jfmpc.jfmpc_238_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.150Performance of Indian diabetic risk score in identifying the undiagnosed type-2 diabetes mellitus among the rural population of Dehradun印度糖尿病风险评分在德拉敦农村人群中识别未诊断2型糖尿病的表现DOI: 10.4103/jfmpc.jfmpc_913_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.151Prevalence and management of renal impairment in adults with type 2 diabetes mellitus in general versus specialized diabetes clinics in primary care in Kingdom of Bahrain巴林王国初级保健中普通诊所与糖尿病专科诊所对2型糖尿病成人患者肾功能损害的患病率和管理比较DOI: 10.4103/jfmpc.jfmpc_440_25
Health science reports IF: 02.100Volume 9, Issue 3No.152Prevalence and Risk Factors for Diabetic Peripheral Neuropathy Among Malagasy Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study马达加斯加2型糖尿病患者糖尿病周围神经病变的患病率及危险因素：一项横断面研究DOI: 10.1002/hsr2.72209
Case reports in orthopedics IF: 00.600Volume 2026, Issue No.153Primary Pyomyositis of the Adductor and Pectineus Muscle in Patients With Uncontrolled Diabetes: Report of Two Cases未控制糖尿病患者内收肌和耻骨肌原发性化脓性肌炎：两例报告DOI: 10.1155/cro/6657339
Med J Islam Repub IranVolume 39, Issue No.154Economic Evaluation of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Heart Failure with Preserved or Mildly Reduced Ejection Fraction: A Systematic Review钠-葡萄糖协同转运蛋白2抑制剂在射血分数保留或轻度降低的心力衰竭患者中的经济学评价：系统综述DOI: 10.47176/mjiri.39.161
Renal failure IF: 03.000Volume 48, Issue 1No.155Dapagliflozin improves hemoglobin and anemia in chronic kidney disease: a systematic review and meta-analysis达格列净改善慢性肾脏病患者血红蛋白和贫血：系统评价与荟萃分析DOI: 10.1080/0886022X.2026.2636407
Critical care IF: 09.300Volume 30, Issue 1No.156Expanding awareness of potentially life‑threatening adverse effects of metformin扩大对二甲双胍潜在致命不良反应的认识DOI: 10.1186/s13054-026-06001-0
BMC oral health IF: 03.100Ahead of Print.No.157Diabetes is associated with elevated mortality, stroke, and osteoradionecrosis in squamous cell carcinomas of the head and neck: a systematic review and meta-analysis糖尿病与头颈部鳞状细胞癌死亡率、卒中和骨放射性坏死风险升高相关：系统综述与荟萃分析DOI: 10.1186/s12903-026-08366-8
Clin Exp Hepatol IF: 01.700Volume 11, Issue 3No.158Three-year outcomes under pemafibrate therapy in patients with metabolic dysfunction-associated steatotic liver disease: a long-term observational study佩玛贝特治疗代谢功能障碍相关脂肪性肝病患者的三年结局：一项长期观察性研究DOI: 10.5114/ceh.2025.154217
Curēus IF: 01.300Volume 18, Issue 3No.159Takotsubo Syndrome Mimicking Acute Myocardial Infarction: A Case Report类似急性心肌梗死的Takotsubo综合征：一例病例报告DOI: 10.7759/cureus.105641
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.160Prevalence of health issues among youth in Kolar - findings from a large-scale population-based cross-sectional study科拉尔地区青少年健康问题患病率——一项大规模人群横断面研究结果DOI: 10.4103/jfmpc.jfmpc_868_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.161Liver benefits of early initiation of low-dose GLP-1 receptor agonists in newly diagnosed type 2 diabetes - A case report新诊断2型糖尿病早期启用低剂量GLP-1受体激动剂的肝脏获益：一例病例报告DOI: 10.4103/jfmpc.jfmpc_1596_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.162Osteoarthritis in Saudi Arabia: Unveiling misconceptions and societal determinants of disease interpretation沙特阿拉伯骨关节炎：揭示疾病解读中的误解与社会决定因素DOI: 10.4103/jfmpc.jfmpc_1205_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.163Effectiveness of school-based intervention in obese children学校干预对肥胖儿童的有效性DOI: 10.4103/jfmpc.jfmpc_1909_24
Contemp Clin Trials Commun IF: 01.400Volume 51, Issue No.164Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial儿童哮喘吸气训练的机制研究：一项儿科临床试验的原理与方法DOI: 10.1016/j.conctc.2026.101638
Clinicoecon Outcomes Res IF: 02.200Volume 18, Issue No.165Healthcare Resource Utilization and the Direct Medical Cost of Fibromyalgia Patients in a Tertiary Hospital in Saudi Arabia沙特阿拉伯一家三级医院纤维肌痛患者的医疗资源利用与直接医疗费用DOI: 10.2147/CEOR.S578039
Acta Biochimica Polonica IF: 01.700Volume 73, Issue No.166Genetic architecture of obesity and advances in precision pharmacotherapy: a comprehensive review肥胖的遗传架构与精准药物治疗进展：一项全面综述DOI: 10.3389/abp.2026.15484
Frontiers in sleepVolume 5, Issue No.167Sleep duration and food insecurity among minority urban college students: predictors of health and academic disparity少数族裔城市大学生睡眠时长与食物不安全：健康与学业差异的预测因素DOI: 10.3389/frsle.2026.1759416
Public health challengesVolume 5, Issue 1No.168Leveraging the Positive Deviance Approach to Drive Behavior Change in Noncommunicable Diseases: A Scoping Review利用正向偏差方法推动非传染性疾病行为改变：一项范围综述DOI: 10.1002/puh2.70074
Curēus IF: 01.300Volume 18, Issue 3No.169Tackling Obesity: A Qualitative Exploration of a Whole School Food Policy Guideline应对肥胖：一项关于全校食品政策指南的定性探索DOI: 10.7759/cureus.105629
Curēus IF: 01.300Volume 18, Issue 3No.170Gestational Obstructive Sleep Apnea: From Pathophysiological Mechanisms to Maternal-Fetal Outcomes妊娠期阻塞性睡眠呼吸暂停：从病理生理机制到母胎结局DOI: 10.7759/cureus.105659
Health science reports IF: 02.100Volume 9, Issue 3No.171Critical Evaluation of the Impact of COVID-19 Pandemic on Child Health and Wellbeing and Suggested Preparedness for Future Pandemics-A Narrative ReviewCOVID-19大流行对儿童健康与福祉影响的批判性评估及未来大流行防范建议——一项叙述性综述DOI: 10.1002/hsr2.72073
Health science reports IF: 02.100Volume 9, Issue 3No.172Correlation Between Coagulopathy and Glycemic Control Among People With Type 2 Diabetes Mellitus in the Southwestern Cameroon, a Cross-Sectional Study喀麦隆西南部2型糖尿病患者凝血功能障碍与血糖控制的相关性：一项横断面研究DOI: 10.1002/hsr2.72128
Health science reports IF: 02.100Volume 9, Issue 3No.173Assessment of Lifestyle and Dietary Patterns Among Students at the University of Human Development in Sulaimani City: A Cross-Sectional Study 2025-2026苏莱曼尼亚人类发展大学学生生活方式与膳食模式评估：一项横断面研究（2025-2026）DOI: 10.1002/hsr2.72125
Frontiers in nutrition IF: 05.100Volume 13, Issue No.174Dietary diversity, nutrition knowledge and attitude among adolescents in Addis Ababa: a cross-sectional study亚的斯亚贝巴青少年膳食多样性、营养知识与态度：一项横断面研究DOI: 10.3389/fnut.2026.1696811
Frontiers in oncology IF: 03.300Volume 16, Issue No.175Predictors of sentinel lymph node mapping failure in endometrial cancer: a retrospective multicenter study子宫内膜癌前哨淋巴结显像失败的预测因素：一项回顾性多中心研究DOI: 10.3389/fonc.2026.1799692
Australian prescriber IF: 04.200Volume 49, Issue 2No.176Metabolic dysfunction-associated fatty liver disease: an update代谢功能障碍相关脂肪性肝病：最新进展DOI: 10.18773/austprescr.2026.014
Obesity pillarsVolume 18, Issue No.177Sarcopenic obesity in type 2 diabetes: An underrecognized clinical challenge2型糖尿病中的肌少性肥胖：一个未被充分认识的临床挑战DOI: 10.1016/j.obpill.2026.100270
IJU case reports IF: 00.600Volume 9, Issue 2No.178Delayed Clinical Manifestation of Malignant Potential in a Cortisol-Secreting Adrenal Tumor Initially Diagnosed as Adenoma最初诊断为腺瘤的皮质醇分泌性肾上腺肿瘤恶性潜能的延迟临床表现DOI: 10.1002/iju5.70166
Lancet Reg Health West Pac IF: 08.100Volume 69, Issue No.179Country-specific modifiable dementia risk factors across the Western Pacific Region determined by population attributable fraction西太平洋地区各国可改变痴呆风险因素的人群归因分数分析DOI: 10.1016/j.lanwpc.2026.101857
Saudi journal of anaesthesiaVolume 20, Issue 2No.180Cauda equina syndrome in an obese parturient following cesarean section under combined spinal-epidural anesthesia肥胖产妇在腰硬联合麻醉下剖宫产后发生马尾综合征DOI: 10.4103/sja.sja_822_25
Ophthalmology science IF: 04.600Volume 6, Issue 5No.181Genetic and Phenotypic Characterization of a Large Cohort of Patients with BBS1-RetinopathyBBS1相关视网膜病变患者大型队列的遗传与表型特征分析DOI: 10.1016/j.xops.2026.101164
Ophthalmology science IF: 04.600Volume 6, Issue 5No.182Retinomics as a Tool for Glaucoma Prediction视网膜组学作为青光眼预测工具DOI: 10.1016/j.xops.2026.101163
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.183Diagnosing and treating fatty liver disease: strategies for hepatocellular carcinoma and cardiovascular disease prevention脂肪性肝病的诊断与治疗：肝细胞癌与心血管疾病预防策略DOI: 10.5114/ceh.2025.155228
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.184Metabolic dysfunction-associated steatotic liver disease in children儿童代谢功能障碍相关脂肪性肝病DOI: 10.5114/ceh.2025.155319
Med J Islam Repub IranVolume 39, Issue No.185Symptom Severity and Duration of COVID-19 Are Correlated with the Healthy Eating Index (HEI) Among Hospitalized Elderly Patients住院老年COVID-19患者症状严重程度和病程与健康饮食指数的相关性DOI: 10.47176/mjiri.39.142
Med J Islam Repub IranVolume 39, Issue No.186The Iranian Consensus on Self-Monitoring of Blood Glucose: An Expert Consensus伊朗自我血糖监测共识：专家共识DOI: 10.47176/mjiri.39.147
Med J Islam Repub IranVolume 39, Issue No.187Efficacy of Topical Chamomile and Dill Oil on Abdominal Obesity in Women Ages 25-55 Years: A Randomized Clinical Trial局部洋甘菊和莳萝油对25-55岁女性腹型肥胖的有效性：一项随机临床试验DOI: 10.47176/mjiri.39.155
Clinical nephrology IF: 01.000Ahead of Print.No.188Evaluation of epicardial adipose tissue in children with chronic kidney disease慢性肾脏病儿童心外膜脂肪组织的评估DOI: 10.5414/CN111925
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.189Endogenous oxalate synthesis in mouse models of metabolic dysfunction-associated steatotic liver disease代谢功能障碍相关脂肪性肝病小鼠模型中的内源性草酸合成DOI: 10.1152/ajprenal.00308.2025
Journal of medical economics IF: 03.000Volume 29, Issue 1No.190Enhancing economic modelling in obesity: integrating novel type 2 diabetes progression & obstructive sleep apnea remission - a UK case study肥胖经济模型优化：整合新型2型糖尿病进展与阻塞性睡眠呼吸暂停缓解——英国案例研究DOI: 10.1080/13696998.2026.2646079
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.191Impact of Cardiometabolic Risk Factors and Steatotic Liver Disease on Liver-Related Outcomes in Patients With Chronic Hepatitis C After Curative Antiviral Therapy心脏代谢危险因素和脂肪性肝病对慢性丙型肝炎患者治愈性抗病毒治疗后肝脏相关结局的影响DOI: 10.1002/kjm2.70214
J Nepal Health Res CouncVolume 23, Issue 4No.192Association of Salt Taste Sensitivity Threshold with Blood Pressure and Obesity Indicators among Healthy Young Adults健康年轻成人咸味敏感阈值与血压及肥胖指标的关系DOI: 10.33314/jnhrc.v23i04.4727
BMC musculoskeletal disorders IF: 02.400Ahead of Print.No.193Does body mass index independently affect functional outcomes after conservatively treated distal radius fractures? a retrospective cohort study体重指数是否独立影响保守治疗后桡骨远端骨折的功能结局？一项回顾性队列研究DOI: 10.1186/s12891-026-09879-7
Journal of medical investigation IF: 00.700Volume 73, Issue 1.2No.194Key Biomarkers and Physical Performance Indicators Associated with Pre-Frailty and Frailty in Patients with Chronic Schizophrenia aged < 65 years慢性精神分裂症患者（年龄<65岁）中与衰弱前期和衰弱相关的关键生物标志物及身体表现指标DOI: 10.2152/jmi.73.12
Nihon kōshū eisei zasshiAhead of Print.No.195[Utilizing administrative data to enhance the Health Management Support Program for public assistance recipients aged <40 years: Lessons from Toyonaka City]利用行政数据加强针对40岁以下公共援助受助者的健康管理支持计划：来自丰中市的经验DOI: 10.11236/jph.25-107
The American journal of nursing IF: 02.000Volume 126, Issue 5No.196Rapid weight regain after discontinuation of weight management medications停用体重管理药物后快速体重反弹DOI: 10.1097/AJN.0000000000000300c
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.197Knowledge and awareness about microvascular complications of diabetes mellitus among Taif University medical students塔伊夫大学医学生对糖尿病微血管并发症的认知与意识DOI: 10.4103/jfmpc.jfmpc_1457_25
Int J Nanomedicine IF: 06.500Volume 21, Issue No.198Calcium Carbonate-Stabilized Nano-Caffeine Emulsion Attenuates Diabetic Cardiomyopathy via Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Pathways in Type 2 Diabetic Rats with HPLC-Quantified Cardiac Caffeine Levels碳酸钙稳定的纳米咖啡因乳液通过抗氧化、抗炎和抗纤维化途径减轻2型糖尿病大鼠糖尿病心肌病并伴有HPLC定量心脏咖啡因水平DOI: 10.2147/IJN.S573949
Clin Exp Hepatol IF: 01.700Volume 11, Issue 4No.199Potential pharmacotherapy pathways in metabolic dysfunction-associated steatotic liver disease代谢功能障碍相关脂肪性肝病的潜在药物治疗路径DOI: 10.5114/ceh.2025.154956
J Nepal Health Res CouncVolume 23, Issue 4No.200Prevalence and Predictors of Glycemic Control among Diabetic Patients in in Lalitpur, Nepal尼泊尔拉利特普尔糖尿病患者血糖控制现状及预测因素DOI: 10.33314/jnhrc.v23i04.4696
The Nurse practitioner IF: 00.900Volume 51, Issue 5No.201GLP-1 receptor agonists: The good, the bad, and the ugly-A comprehensive guide for NPsGLP-1受体激动剂：好、坏与丑——执业护士综合指南DOI: 10.1097/01.NPR.0000000000000430
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.202Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR-Based β-Cell Replacement and Treg Immune Modulation Approaches1型糖尿病的基因治疗与基因编辑：基于CRISPR的β细胞替代和Treg免疫调节方法DOI: 10.1111/dom.70800
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.203Integrated miRNA-mRNA Analysis Reveals Obesity-Driven Regulatory Networks in Human Visceral Adipose Tissue With and Without Type 2 Diabetes整合miRNA-mRNA分析揭示肥胖驱动的人内脏脂肪组织调控网络：伴或不伴2型糖尿病DOI: 10.1111/dom.70787
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.204The effect of fasting Ramadan on type 2 diabetes: A narrative review and practice update斋月禁食对2型糖尿病的影响：叙述性综述与实践更新DOI: 10.4103/jfmpc.jfmpc_1118_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.205When type 1 diabetes isn't the answer: A case series of siblings with misdiagnosed diabetes mellitus later confirmed as maturity-onset diabetes of the young当1型糖尿病不是答案：一例被误诊为糖尿病的兄弟姐妹后确诊为青少年起病的成人型糖尿病的病例系列DOI: 10.4103/jfmpc.jfmpc_1747_25
J Family Med Prim Care IF: 01.000Volume 15, Issue 2No.206A case of once-weekly basal insulin therapy for a dementia patient with Type 2 Diabetes mellitus and living alone每周一次基础胰岛素治疗独居痴呆合并2型糖尿病患者的病例报告DOI: 10.4103/jfmpc.jfmpc_1936_25
Frontiers in medicine IF: 03.000Volume 13, Issue No.207Biologics and biosimilars medication errors in Saudi Arabia: a nationwide retrospective observational real-world study沙特阿拉伯生物制剂与生物类似药用药错误：一项全国性回顾性观察性真实世界研究DOI: 10.3389/fmed.2026.1795867
Chronic Dis Transl MedVolume 12, Issue 1No.208Exploring the Anti-Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials探索花青素的抗糖尿病潜力：从生化途径到人体试验DOI: 10.1002/cdt3.70033
Respirology case reports IF: 00.800Volume 14, Issue 3No.209Cystic Fibrosis-Related Diabetes and Celiac Disease in a Paediatric CF Patient: Presence of CFRD-Associated SNPs rs7903146 (TT) and rs4077468 (GG)儿童囊性纤维化患者中囊性纤维化相关糖尿病与乳糜泻共存：CFRD相关SNP rs7903146（TT）和rs4077468（GG）的存在DOI: 10.1002/rcr2.70551
JCEM case reportsVolume 4, Issue 5No.210Early GH therapy and neurodevelopmental outcome in a child with compound heterozygous IGF1R variants早期GH治疗对复合杂合IGF1R变异儿童神经发育结局的影响DOI: 10.1210/jcemcr/luag081
Clin Exp Hepatol IF: 01.700Volume 11, Issue 3No.211Recommendations for hypolipidemic and antithrombotic therapy in HCV-infected patients treated with direct-acting antiviral agents: expert position statement直接抗病毒药物治疗的丙型肝炎病毒感染患者降脂和抗血栓治疗建议：专家立场声明DOI: 10.5114/ceh.2025.154978
J Nutr Metab IF: 02.400Volume 2026, Issue No.212The Safety Profile of Aspartame: A Review of Regulatory Standards and Emerging Health Concerns阿斯巴甜的安全性：监管标准与新兴健康问题综述DOI: 10.1155/jnme/4727546
J Clin Exp Hepatol IF: 03.200Volume 16, Issue 4No.213Sex Differences in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Epidemiology, Pathophysiology, and Clinical Implications代谢功能障碍相关脂肪性肝病的性别差异：流行病学、病理生理学及临床意义DOI: 10.1016/j.jceh.2026.103533
Saudi journal of anaesthesiaVolume 20, Issue 2No.214Anesthesia considerations in pediatric pancreatectomy for congenital hyperinsulinemic hypoglycemia: A retrospective case series先天性高胰岛素血症低血糖患儿胰腺切除术的麻醉考量：一项回顾性病例系列研究DOI: 10.4103/sja.sja_869_25
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 4No.215Craniofacial Fracture and Secretome: A Systematic Review颅面骨折与分泌组：一项系统综述DOI: 10.1097/GOX.0000000000007482
Canadian journal of zoologyVolume 104, Issue No.216Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care冬眠启发的生物医学创新：应对衰老、慢性疾病和重症监护DOI: 10.1139/cjz-2025-0055
Circulation Research IF: 16.200Ahead of Print.No.217Endothelial NOX1 Drives Obesity via Skeletal Muscle Mitochondrial Dysfunction内皮NOX1通过骨骼肌线粒体功能障碍驱动肥胖DOI: 10.1161/CIRCRESAHA.125.326768
J Biochem Mol Toxicol IF: 02.800Volume 40, Issue 5No.218Melatonin and Quercetin Co-Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation褪黑素和槲皮素联合治疗通过减轻氧化应激和炎症缓解糖尿病大鼠的肝脏损伤DOI: 10.1002/jbt.70855
Lipids in health and disease IF: 04.200Ahead of Print.No.219Untargeted plasma lipidomic profiling associated with pediatric metabolic dysfunction-associated steatohepatitis (MASH)非靶向血浆脂质组学分析在儿童代谢功能障碍相关脂肪性肝炎（MASH）中的应用DOI: 10.1186/s12944-026-02937-y
Journal of medical investigation IF: 00.700Volume 73, Issue 1.2No.220Sex differences in the impact of structured education together with isCGM in individuals with type 1 diabetes:post hoc analysis of the ISCHIA study1型糖尿病患者中结构化教育与间歇性扫描持续葡萄糖监测联合干预效果的性别差异：ISCHIA研究的事后分析DOI: 10.2152/jmi.73.74
Journal of medical investigation IF: 00.700Volume 73, Issue 1.2No.221Effect of glucose load on metabolism in patients with type 2 diabetes during elective surgery using remifentanil-induced anesthesia:a randomized controlled trial葡萄糖负荷对瑞芬太尼麻醉下择期手术2型糖尿病患者代谢的影响：一项随机对照试验DOI: 10.2152/jmi.73.222
JAAD case reportsVolume 71, Issue No.222Treatment of recurrent facial ulcerations and dysesthesias from trigeminal trophic syndrome with chronic transcutaneous vagus nerve stimulation慢性经皮迷走神经刺激治疗三叉神经营养综合征引起的复发性面部溃疡和感觉异常DOI: 10.1016/j.jdcr.2026.03.035
Health science reports IF: 02.100Volume 9, Issue 3No.223Adherence to Insulin Treatment in People With Type 1 or Type 2 Diabetes in Primary Health Care in a Brazilian City: A Cross-Sectional Study巴西某城市初级卫生保健中1型或2型糖尿病患者胰岛素治疗依从性的横断面研究DOI: 10.1002/hsr2.72105
Current eye research IF: 02.000Ahead of Print.No.224Intraocular Distribution and Aqueous-Vitreous Correlation of TGF-β Isoforms and GDF-15 in Retinal Diseases视网膜疾病中TGF-β亚型与GDF-15的眼内分布及房水-玻璃体相关性DOI: 10.1080/02713683.2026.2660821
Annals of African medicine IF: 00.600Ahead of Print.No.225Real-world Impact of Antivascular Endothelial Growth Factor Treatment on Visual and Anatomical Outcomes in Diabetic Macular Edema: A Prospective Observational Study抗血管内皮生长因子治疗对糖尿病性黄斑水肿视觉和解剖学结局的真实世界影响：一项前瞻性观察研究DOI: 10.4103/aam.aam_751_25
IbrainVolume 12, Issue 1No.226RETRACTED: Clinical effectiveness and treatment satisfaction between two triple-therapy regimens in treating neuropathic pain: A real-world data两种三联疗法治疗神经病理性疼痛的临床有效性和治疗满意度：一项真实世界数据研究DOI: 10.1002/ibra.12143
Kidney medicine IF: 03.400Volume 8, Issue 5No.227Gabapentin Utilization and Adverse Effects Among US Hemodialysis Patients Diagnosed With Pruritus or Neuropathic Pain美国血液透析患者中加巴喷丁的使用与不良事件：基于瘙痒或神经病理性疼痛诊断的分析DOI: 10.1016/j.xkme.2026.101341
Res Pract Thromb Haemost IF: 03.400Volume 10, Issue 3No.228Cathepsin G is associated with cerebral vascular injury in myeloid leukemia: a pathologic insight into intracranial hemorrhage组织蛋白酶G与髓系白血病脑血管损伤相关：颅内出血的病理学新见解DOI: 10.1016/j.rpth.2026.103433
Frontiers in medicine IF: 03.000Volume 13, Issue No.229Strengths and limitations of HFpEF probability scores in the era of precision medicine精准医学时代射血分数保留的心力衰竭概率评分的力量与局限DOI: 10.3389/fmed.2026.1799451
Current nutrition reports IF: 05.500Volume 15, Issue 1No.230Comparative Analysis of Adipokines and Growth Factors in Preterm and Term Breast Milk and Their Role in Infant Growth早产与足月母乳中脂肪因子和生长因子的比较分析及其在婴儿生长中的作用DOI: 10.1007/s13668-026-00758-0
Pregnancy Hypertension IF: 02.900Volume 44, Issue No.231Self-reported primary preventive follow-up of women’s cardiovascular health after hypertensive pregnancy complications and gestational diabetes妊娠期高血压并发症和妊娠期糖尿病后女性心血管健康自我报告的一级预防随访DOI: 10.1016/j.preghy.2026.101474
200
Diabetes Mellitus(DM)
糖尿病
102
Obesity
肥胖症
65
Insulin
胰岛素
31
Type 2 diabetes mellitus(T2DM)
2型糖尿病
11
Diabetic Retinopathy
糖尿病视网膜病
9
Diabetic Foot
糖尿病足
9
Metabolic Syndrome
代谢综合征
7
Metformin
二甲双胍
7
Semaglutide
司美格鲁肽
6
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
6
Diabetes Complications
糖尿病并发症
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
4
Hypoglycemic Agents
降糖药
4
Diabetic acidosis
糖尿病性酸中毒
4
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
3
Empagliflozin
恩格列净
3
Diabetic Neuropathies
糖尿病性神经病变
3
Gabapentin
加巴喷丁
3
Tirzepatide
替尔泊肽
2
Dulaglutide
度拉糖肽
2
Liraglutide
利拉鲁肽
2
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
2
Pregabalin
普瑞巴林
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
Dapagliflozin
达格列净
1
Ertugliflozin
艾托格列净
1
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
1
Alogliptin
阿格列汀
1
Lixisenatide
利司那肽
1
Exenatide
艾塞那肽
1
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
编辑：韩玉莲
审校：韩玉莲
2026-04-24
·雪球
【恒瑞医药2026年第一季度业绩交流会会议纪要】会议时间：2026年4月23日上午会议形式：线上电话会议参会领导：公司董事总裁冯总、早研创新合作官贺总、CFO刘建军总、资本市场负责人尼娜总、董秘刘笑涵总、证券事务代表田飞等一、会议开场与参会人员介绍会议开始，公司证券事务代表田飞作为主持人，对各位投资者的参会表示欢迎，并介绍了出席本次会议的公司领导。特别值得一提的是，公司早研创新合作官贺总（贺峰博士）首次参加公司的业绩电话会。贺总2015年加入恒瑞后一直领导公司的早期研发工作，是公司ADC平台以及多款重磅产品的重要发明人之一，拥有超过26年的全球产业早研经验，曾在BMS、诺华和罗氏等跨国药企从事创新药研发工作。今年3月，贺总出任公司早研创新合作官，全面统筹早研及商务发展工作，着力加强公司国际化研发。二、公司总裁冯总介绍经营业绩与战略进展冯总首先对2026年第一季度的经营业绩进行了回顾。在报告期内，恒瑞继续延续了稳健的增长态势，创新与国际化双轮驱动战略持续深化。公司实现营业收入81.41亿元，同比增长12.98%；归母净利润22.8亿元，同比增长21.78%；创新药收入45.2亿元，同比增长25.75%，增速较去年同期显著提升，占药品销售收入比重达61.69%。创新驱动的收入结构优化趋势进一步显现，创新药已经成为公司业绩增长的绝对核心引擎。随着新产品及新适应症的持续获批，以及已纳入医保的创新药加速准入进院，公司有信心在2026年实现创新药销售收入增长超过30%的全年目标。仿制药收入因公司战略性收缩等原因，收入占比将逐年下降，公司业务结构持续向创新驱动转型。在创新研发成果方面，一季度研发管线迎来了多个里程碑。公司研发的PD-L1/TGF-β双特异性抗体融合蛋白（商品名：艾瑞利？原文为“PDMYTTF贝塔双特异性抗体融合蛋白”，应指SHR-1701）获批上市，用于胃癌的一线治疗，成为全球首个获批的此类双抗。注射用瑞康曲妥珠单抗（商品名：艾维达）新增了HER2阳性乳腺癌适应症，这是该产品获批上市的第二个适应症，也是在乳腺癌治疗领域获批的首个适应症，获批一个月内已被快速纳入2026年版中国临床肿瘤学会乳腺癌诊疗指南。该产品目前仍有晚期结直肠癌适应症已提交上市申请，八项适应症处于三期临床研究，未来几年有望带来可观的商业化增量。海曲泊帕乙醇胺片（商品名：恒曲）新增初诊重症再生障碍性贫血适应症，成为中国首个且唯一获得该适应症批准的TPO-RA类药物。今年预计还将新增两项适应症，其中化疗所致血小板减少症（CIT）患者基数庞大，是极具潜力的重磅适应症。在研发投入方面，公司持续加码源头创新，一季度研发投入达到22.24亿元。报告期内累计取得临床研究获批通知书26个，有八项适应症创新药上市申请已获NMPA受理。2026年以来，获得CDE突破性治疗品种认定六项，其中瑞康曲妥珠单抗第11次纳入突破性治疗名单。全年来看，公司预计还会有十项以上的NDA/BLA申报，并计划获批约九项创新药或新适应症，创新动能充足，管线厚度持续提升。在国际化方面，公司的全球合作有序推进。2025年公司对外许可收入已达33.92亿元，已成为营业收入的重要组成部分。一季度确认许可收入7.87亿元，主要是GSK根据履行义务的完成进度确认的收入。值得关注的是，2026年4月16日，公司的合作伙伴Kailera成功在美国纳斯达克挂牌上市，募集资金约6.25亿美元，为生物技术领域有史以来规模最大的IPO。从2024年5月达成授权合作到成功登陆纳斯达克，Kailera仅用了不到两年的时间，充分彰显了资本市场对恒瑞GLP-1产品组合全球竞争力的高度认可，标志着公司“NewCo”出海模式取得了实质性突破，全球化创新合作路径进一步获得验证。展望全年，公司将依托持续的创新研发、有序的国际化拓展及高效的商业化落地，推动业绩逐步增长，力争实现创新药销售收入增长超过30%的年度目标。三、CFO刘建军总介绍财务数据刘建军总对公司一季度的财务数据做了详细拆解。一季度营业收入81.4亿元，同比增长12.9%。创新药销售收入45.2亿元，同比增长25.12%，占产品销售总收入比重达65.6%。其中，抗肿瘤创新产品收入33.1亿元，同比增长11.5%，占整体创新药收入的73.2%；代谢及其他产品收入12.94亿元，同比增长28.5%，占创新药收入的26.8%。仿制药收入28.3亿元，同比减少7.2%，新产品带来的收入增长部分弥补了仿制药集采调整所带来的影响。一季度归母净利润22.8亿元，利润增长主要是由于收入的增长大于研发费用、销售费用及管理费用的增长。受美元汇率波动影响，公司持有的美元资产产生未实现的汇率损失约4亿元。公允价值变动方面，公司持有的Kailera股权确认收益1.2亿元。四、问答环节（一）关于创新药全年增长目标及新进医保产品的放量情况（中信证券安飞）冯总回答：一季度创新药收入同比增长25.75%，较去年同期的20%提高了五个多百分点，创新药占药品总收入比例从去年一季度的54.5%提升到了61.75%，增长强劲。公司对全年实现30%的创新药增长充满信心。多款新产品、新适应症进入医保并于年初逐步落地，三月份医院准入相比一、二月份有明显加速，战略医院全年准入目标第一季度完成情况符合预期。2026年潜在获批上市的产品及新适应症共12项，目前已有三项获批，包括瑞康曲妥珠单抗在HER2阳性乳腺癌适应症（已在一个月内进入国家指南推荐），年内还有舒地胰岛素注射液、海曲泊帕的CIT适应症、达尔西利在HR阳性乳腺癌辅助治疗等新产品及新适应症将获批。（二）关于医保准入进度、价格及医疗反腐环境（广发医药罗佳荣）冯总回答：准入进度方面，一季度符合预期。12月份进度较慢，但三月份开始各地药事会召开较多，医院采购较快，国产药品配套政策在各地持续完善。恒瑞本次国家医保谈判有20个产品及适应症纳入医保，包括10款新产品（如PD-L1/TGF-β双抗、PCSK9降脂药、自身免疫领域的白介素-17等），相比2025年的三款新产品大幅提升。价格方面，续约产品价格调整在1月1日各地都已体现，销量是逐步过程。医疗反腐方面，恒瑞非常支持国家政策，公司五六年前就已开始合规转型，在行业内走在前列，当前政策对公司而言更多是竞争机会。（三）关于仿制药下滑趋势及全年预测（深圳医药杨丞丞）冯总回答：一季度仿制药下滑约7%，但受到集采执行节奏、医院准入周期、产品结构等多重因素影响，波动较大，不建议以此作为全年预测依据。公司在战略层面已明确战略性收缩仿制药资源，仿制药收入将逐年下滑，创新药收入连续性提升。部分仿制药新产品如布比卡因脂质体取得增长，眼科仿制药恒信今年新进医保也在持续放量，美国市场的白蛋白紫杉醇也贡献了稳定海外增量。建议投资者更多关注创新药放量节奏、医保准入进展及BD里程碑兑现。（四）关于RAS领域产品组合及差异化优势（华泰医药李伟）贺总回答：RAS是人类癌症中约20%的驱动基因，过去被认为是不可成药靶点，但最近技术已突破。恒瑞很早就布局了RAS领域，是全方位的。HRS-4642是全球第一款针对KRASG12D的三代产品，主要适应症是胰腺癌，临床数据显示ORR超过13%，有望成为best-in-class。关于KRASG12D口服抑制剂，公司特别注重分子的外排能力，使其能够快速从肠道细胞进入血液，提高生物利用度，同时控制组织分布。关于pan-KRAS抑制剂，公司希望实现更合理的组织分布，减少对皮肤的副作用。（五）关于KaileraIPO的影响及海外临床进展（国海医药曹乐韵）CFO刘总回答：到3月底，公司参考Kailera上市前最后一轮融资价格确认了1.2亿元的股权收益。IPO后，公司将更多参考Kailera在美股的股价来确定后续公允价值。贺总补充：HRS-9531的三期临床去年12月已启动，今年计划完成三个临床试验的随机入组，同时启动高剂量组的ToB研究。两个口服项目——口服9531上半年启动，口服小分子7535年中启动，还有三靶点4729的一期研究年底前启动。（六）关于BD收入确认（国联民生胡若碧）冯总回答：一季度确认的7.87亿元BD收入主要包括与GSK合作的PD-L1/TGF-β双抗等项目的许可收入首付款确认以及按合作研发进度确认的收入。2026年针对GSK预计还有约2.5亿美元的收入确认空间。（七）关于近期研发和临床技术进展（中信建投医药陈伟佳）贺总分享了近期多个重要进展。心血管领域，HRS-1893（针对梗阻性肥厚型心肌病）在ACC会议上以最新突破性口头报告形式公布了亮眼的二期数据。该产品最大的特点是剂量调整期非常短——大部分病人一周内可搞定，最多不超过三周，而竞品需要1-3个月频繁调整剂量。疗效方面，应答率超过80%，12周后在最优剂量下超过86%的患者完全解除梗阻症状。安全性方面，无不良事件导致治疗终止，不良事件均为轻度。该产品同时还针对非梗阻性肥厚型心肌病开展临床，二期数据将于今年5月在ESC心力衰竭大会上公布。自身免疫领域，IL-23p19/IL-36R双靶点抗体，针对中重度斑块状银屑病，近期在AAD公布了亮眼数据，最大亮点是有望实现一年给药一次。HER3ADC（HRS-1608？原文为herthreeADC）可能是全球第一个接近商业化的HER3ADC产品，在欧洲肺癌大会上披露了三项临床研究结果，针对EGFR突变阳性非小细胞肺癌，预计今年报NDA。HER2ADC（SHR-A1811）是公司的明星产品，已获批肺癌和乳腺癌，更多适应症将陆续披露。其HER2表达突变的非小细胞肺癌二期临床数据正在AACR上以口头报告形式披露，数据非常亮眼。（八）关于ASCO值得关注的数据（国泰海通廖博文）贺总回答：ASCO值得关注的数据包括：SHR-A1811与标准疗法对比治疗化疗耐药、已进展的HER2阳性结直肠癌的三期临床数据，这是首个HER2ADC在结直肠癌的关键研究。另外，HER2ADC在乳腺癌低表达适应症的数据今年也会陆续出炉，患者人群非常庞大，若患者能够获益，商业价值将极大提升。Nectin-4ADC联合阿德贝利单抗治疗膀胱癌的二期数据也将在ASCO公布。（九）关于药品价格形成机制政策的影响（中国证券杨金灿）冯总回答：今年4月14日国务院发布的健全药品价格形成机制若干意见，是2015年以来中央层面最高等级的药品定价指导文件。恒瑞非常欢迎该文件。具体利好包括：首发定价机制帮助高价值创新药实现合理回报；医保谈判预期更加稳定，续约降幅更可控，医疗机构不得以谈判药品进行议价；多元支付体系打破单一医保依赖，为商保等创新支付路径奠定基础；对仿制药也有稳定预期的作用，集采规则持续优化。整体而言，九号文增强了创新业务增长的确定性、回报的稳定性和长期投资价值。（十）关于GLP-1/GIP双靶点产品HRS-9531的差异化优势及营销策略（国金证券张晓华）冯总回答：HRS-9531化学名为瑞普博泰。中国有约3亿人口需要体重管理（BMI>28或BMI>24且有并发症），市场巨大。产品差异化优势显著：6毫克治疗48周降低体重19.2%，无平台期，与替尔博肽15毫克52周降幅相当；腰围减少14.4厘米，hs-CRP降低49%，收缩压降低10毫米汞柱，甘油三酯降低40%，在内脏脂肪、尿酸、血糖、胰岛素抵抗、尿蛋白等多维度均有明显改善；半衰期7天，可实现每两周一次给药；胃肠道不良反应致停药率仅0.2%。营销策略方面：全渠道专业服务，医院端和客户端双向驱动，电商与零售双向赋能，核心医疗机构与非公渠道双向覆盖，从一线城市到县域市场全覆盖；利用新媒体渠道（小红书、抖音等）进行合理信息传播；品牌定位为国产双靶点创新药在代谢与体重管理领域的标杆；以全面扎实的医学证据链为核心支撑，推进多囊卵巢综合征、睡眠呼吸暂停综合征等适应症拓展；已配备有丰富经验的市场及电商管理高管，积极与电商平台同步合作。五、会议总结本次业绩交流会上，公司管理层全面介绍了2026年一季度的经营情况。创新药收入持续高增长，占药品收入比重已超61%，仿制药收入占比逐年下降，创新驱动转型成效显著。研发管线密集兑现，多个重磅产品及适应症进入关键临床或申报阶段。国际化方面，Kailera成功IPO标志着NewCo出海模式取得突破。药品价格形成机制新政策为公司创新药业务提供了更有利的制度保障。公司对全年实现创新药收入增长超过30%的目标充满信心。备注：一：本纪要根据公开研究报告内容整理，仅供参考，具体数据以公司正式公告为准。如涉及非公开信息，请及时联系下架！二：公主好，新上线现场音频。每日十家企业内部调研纪要，每日更新伦敦金属交易所（LME)主要有色金属库存数据。
2026-04-24
医学科技的每一步发展与创新，
都是助力患者康复的力量
科技成果：
2025年上海市抗癌科技奖一等奖：王理伟教授团队《胰腺癌个性化精准诊疗体系的建立和推广应用》
主要完成人：
王理伟，崔玖洁，薛婧，张晓飞，徐海燕，焦锋，王宇，毛铁波，牛宁宁
本篇科普大使：
王理伟
项目简介
胰腺癌被称为“癌中之王”，5年生存率不足10%，严重威胁我国国民健康。胰腺癌诊治领域存在三个关键“瓶颈”问题：①早期诊断困难；②分子分型不明确；③缺乏有效治疗药物，从而导致其预后极差。项目组历时12年，围绕此三个关键问题开展一系列原创性研究，取得一系列创新性成果，发表论文204篇，SCI论文146篇，累计影响因子906，IF＞10分46篇，累计他引4380次。牵头制定5部指南，承担国家级项目23项，人才计划9项，培养研究生40人。在胰腺癌诊治领域有重大创新， 为提升我国胰腺癌规范化诊治水平作出了引领性贡献。
捕捉癌变轨迹，绘制基因图谱……胰腺癌诊治又有了新突破
在各类恶性肿瘤里，胰腺癌一直是预后极差、诊疗难度极高的一种，也被大众称作“癌中之王”。长久以来，它早期难发现、治疗缺手段、用药无精准方案的难题，始终困扰着临床医生与广大患者。针对胰腺癌临床诊治的重重困境，科研团队深耕多年，针对性攻破核心难点，一步步推动胰腺癌诊疗向前迈进，也给更多患者带来了治疗希望。
难点一： 早期癌变“隐匿无踪”，缺乏预警信号与干预手段。
胰腺位于腹腔深部，毗邻胃肠、肝胆等多个脏器，早期肿瘤体积微小、未侵犯周围结构时，几乎不会产生特异性症状。即便出现轻微上腹不适、腹胀、食欲减退、乏力或腰背部隐痛等症状，也与慢性胃炎、消化不良、胆囊炎、腰肌劳损等常见良性疾病高度相似，极易被患者自行忽视或被首诊误诊。临床上，既没有像胃肠镜那样可直接观察的常规筛查手段，也缺乏灵敏度和特异度均理想的血清学标志物，导致早期癌变难以被主动发现。多数患者直至肿瘤进展压迫胆管出现黄疸、侵犯神经引发持续性剧痛、或出现明显消瘦体重下降时才得以确诊，此时往往已属局部晚期或远处转移，彻底丧失根治性手术的最佳时机。
创新及改变：探索炎症到癌的转化路径，给胰腺癌踩住刹车
虽然不是所有的炎症都会进展为癌，但慢性胰腺炎是胰腺癌的重要危险因素之一。团队多年深耕，从炎症到癌这一通路入手，找出癌变的关键节点——Sp1转录因子，它在失控下会催生异常细胞，还会干扰免疫细胞功能，最终促成癌变；同时还找到了Stat通路、IL22/IL22RA1信号轴等关键链条，再次捕捉到细胞癌变的路径，将原本微观、不可见的恶变过程，转化为清晰可追踪的轨迹。
基于上述发现，团队还找到了多个可干预的药物靶点，能在炎转癌的早期阶段就及时“踩刹车”，通过调控炎症、修复异常细胞，从源头阻断癌变进程；同时还发现了调控免疫细胞、延缓胰腺纤维化的新方法，帮高危人群筑牢防护墙。
难点二：缺乏特效药，新药研发与个性化试药难
一直以来，胰腺癌缺乏针对性强、效果好的药物，很多药物的有效性也仅止步于实验室阶段。为何会出现这样的局面？因为传统的实验模型太简单，无法模拟每个人体内复杂的肿瘤环境。胰腺癌患者常面临“盲目试药”的困境：哪种药对我有效？有没有更适合我的方案？过去只能靠医生经验猜，缺乏科学依据，患者在不断试错的过程中，可能就错过了最佳的治疗时机。
创新及改变：建立“替身”模型库与大数据平台，实现“量体裁衣”式精准治疗
团队为了打破盲目试错的困局，做了以下努力：
① 打造“替身”：建立了全国最早的胰腺癌“人源肿瘤异种移植（PDX）”模型库（近200例）。把患者的肿瘤组织移植到小鼠身上，形成患者的“替身”，提前把一道关，哪种药有效就用哪种，实现真正的个性化精准试药。
② 建立数据库：团队搭建起全国最大晚期胰腺癌数据库，收录27000例真实病例数据，联动全国50家三甲医院、近200名学科带头人。数据显示该病男性高发，吸烟、糖尿病等为高危因素，临床用药差异贴合患者实际状况，也为优化我国胰腺癌患者的诊疗指南提供了硬核依据。
③ 解密基因图谱：胰腺癌异质性极强，患者肿瘤基因差异极大，精准诊疗与新药研发都亟需国人专属基因数据，团队完成了国内最大样本量的国人胰腺癌基因组测序研究，填补了领域空白。通过对1080例患者肿瘤及血液样本测序，探明了多项国人胰腺癌特有基因规律：我国患者KRAS基因突变率低于西方人群，对应突变位点特征明确，且转移性胰腺癌基因突变更丰富，超两成患者存在DDR基因突变，ATM为主要突变基因，各类基因特征也对应着不同发病与病情进展特点。这套国人专属胰腺癌基因图谱，为精准靶向治疗、新药研发提供了核心科学依据。
从替身试药、大数据导航，到基因精准治疗，这一系列创新为胰腺癌诊疗创建了一个精准化、个性化的路径，有望让胰腺癌逐渐转变为临床上可预测、可干预、可精准狙击的疾病。
难点三：免疫治疗难有突破，晚期患者生存期难以延长
免疫疗法已经在一些肿瘤的诊治中大展拳脚，但在胰腺癌中却几乎无效。原因是胰腺癌周围有一层厚厚的“保护盾”——免疫抑制微环境，阻挡了免疫细胞进入。此外，一旦一线化疗失败，过去国内长期缺乏有效的二线治疗方案，患者往往陷入“无药可用”的绝望境地。
创新及改变：打破免疫“保护盾”，确立国产新药二线治疗新标准
团队发现了肿瘤微环境中一类特殊的癌相关成纤维细胞亚型（meCAF）是形成“保护盾”的关键，简单来说，这一指标能精准判断患者是否能从免疫治疗中获益，为免疫治疗找准适用人群、制定个性化方案提供了核心依据。基于这一重要发现，团队开创性开展了针对性临床研究，选择肿瘤微环境中具有丰富meCAF的患者，采用卡瑞利珠单抗联合白蛋白紫杉醇、吉西他滨的方案，用于转移性胰腺癌患者的一线治疗。
该项研究成果显示：患者客观缓解率从原本的27%大幅提升至54.3%，疾病控制率更是高达83.6%，还出现了完全缓解的病例，治疗效果远超以往单一免疫治疗方案。这项突破性研究成果，也成功入选全球肿瘤领域最权威的美国ASCO年会，获得了国际学界的一致认可，也为优化晚期胰腺癌一线治疗方案、提升治疗效果迈出了至关重要的一步，为优化晚期胰腺癌一线治疗、提升疗效奠定基础。。
而在二线治疗方面，团队也取得突破性成果——确立国产新药治疗新标准，终结了一线化疗失败后“无药可用”的局面：团队牵头的PANHEROIC-1研究获成功，基于其成果，新版指南将国产伊立替康脂质体联合5-FU/LV列为二线治疗I级推荐，为患者提供了兼顾循证依据与可及性的方案，有效延长生存期、提升生活质量。
在新药探索领域，团队从未停止步伐，持续推进国产新药研发与相关临床探索，不断为患者挖掘新的治疗可能。从一线免疫治疗突破、二线治疗标准确立，到国产新药研发与国际合作，团队的创新成果全方位破解晚期胰腺癌治疗困境，为患者点亮长期生存希望。
迄今为止，胰腺癌依旧是非常棘手的恶性肿瘤，想要彻底攻克依旧任重道远。国内胰腺癌规范化诊疗起步较晚，各地医疗水平不均、诊治标准不统一，患者难以获得同质化治疗。近年来，团队牵头制定多部胰腺癌专属诊疗指南、专家共识，大范围推广规范化诊疗方案，缩小各地诊疗差距，全面提升国内胰腺癌整体诊治水平，引领领域规范化发展，填补了国内多项领域空白。相信随着研究人员一步步努力，胰腺癌“难发现、难治疗、无好药”的困局也将一点点被突破。
排版：莫颖
审核：陆瑶
100 项与 白蛋白结合型紫杉醇 相关的药物交易
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研发状态
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10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肿瘤 | 乌拉圭 | 2025-10-31 | |
| 转移性胰腺癌 | 秘鲁 | 2025-05-14 | |
| 胰腺癌 | 中国 | 2024-01-05 | |
| 转移性胰腺腺癌 | 美国 | 2023-05-11 | |
| 不能切除性胰腺癌 | 日本 | 2014-12-18 | |
| 胃癌 | 日本 | 2013-02-21 | |
| 乳腺癌 | 中国 | 2008-06-30 | |
| 非小细胞肺癌 | 欧盟 | 2008-01-11 | |
| 非小细胞肺癌 | 冰岛 | 2008-01-11 | |
| 非小细胞肺癌 | 列支敦士登 | 2008-01-11 | |
| 非小细胞肺癌 | 挪威 | 2008-01-11 | |
| 胰腺腺癌 | 欧盟 | 2008-01-11 | |
| 胰腺腺癌 | 冰岛 | 2008-01-11 | |
| 胰腺腺癌 | 列支敦士登 | 2008-01-11 | |
| 胰腺腺癌 | 挪威 | 2008-01-11 | |
| 转移性乳腺癌 | 美国 | 2005-01-07 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 晚期乳腺癌 | 临床3期 | 中国 | 2023-04-27 | |
| 进展期胃腺癌 | 临床3期 | 中国 | 2020-03-01 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 阿根廷 | 2019-12-10 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 智利 | 2019-12-10 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 捷克 | 2019-12-10 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 法国 | 2019-12-10 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 匈牙利 | 2019-12-10 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 意大利 | 2019-12-10 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 墨西哥 | 2019-12-10 | |
| PD-L1阳性三阴性乳腺癌 | 临床3期 | 秘鲁 | 2019-12-10 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 42 | 醖願淵積構衊蓋觸簾鹹 = 糧夢窪鏇醖獵艱獵壓襯 積襯齋齋淵獵襯築繭觸 (膚繭鏇餘積遞衊積鑰顧, 壓壓廠淵膚範鑰選膚鏇 ~ 壓鑰築蓋衊齋夢顧淵製) 更多 | - | 2026-04-23 | |||
临床2期 | 40 | (Cohort A: Resectable) | 糧窪遞壓願鏇衊夢築積 = 選願衊齋膚鏇膚廠襯襯 選艱夢構積鏇範淵鏇衊 (構鹽繭鑰淵艱遞獵網襯, 蓋壓顧顧獵選夢餘鹹憲 ~ 糧蓋夢獵艱壓構網獵憲) 更多 | - | 2026-04-22 | ||
(Cohort B: Borderline Resectable/Locally Advanced (Unresectable)) | 糧窪遞壓願鏇衊夢築積 = 簾鏇艱築鹽築壓構製積 選艱夢構積鏇範淵鏇衊 (構鹽繭鑰淵艱遞獵網襯, 觸鏇衊觸積壓顧壓遞糧 ~ 鏇獵網繭築餘膚遞簾選) 更多 | ||||||
临床1期 | 胰腺癌 CYP3A5 expression | 6 | (Metastatic Pancreatic Cancer) | 鏇壓餘衊衊製鬱觸選齋(蓋築鹹鹹鹽醖選夢糧獵) = One patient was hospitalized after 6 weeks of treatment for grade 4 acute respiratory distress syndrome associated with LDH increase and lung ground-glass opacity in the CT scan. Two more asymptomatic cases of ground glass opacity associated with LDH increase were observed. 願廠繭構鬱鹹積網蓋鑰 (衊製觸鹹蓋獵餘願衊淵 ) | 不佳 | 2026-04-21 | |
临床3期 | 非小细胞肺癌 Serial CTRS | 1,275 | Cetuximab + carboplatin/paclitaxel | 顧醖網遞蓋鬱鹹繭淵鑰(顧繭糧選鏇鬱製鑰窪網) = BOR achieved 35% (33–37%) power 壓構獵範鑰繭鬱衊獵鏇 (願淵餘鹹顧範艱選鏇觸 ) 更多 | 积极 | 2026-04-20 | |
N/A | 36 | (Frail patients unsuitable for 3-weekly chemotherapy) | 蓋觸廠齋壓醖夢壓衊鹽(膚繭醖膚鑰範膚鏇膚艱) = Weekly TC was overall well tolerated, with low rates of neutropenia(11%), anaemia(22%), thrombocytopenia(3%), fatigue(6%), neurotoxicity(8%) and gastrointestinal toxicity(3%), and no cutaneous events 構製膚餘鏇壓襯壓醖夢 (簾膚憲鬱觸網選艱簾繭 ) | 积极 | 2026-02-28 | ||
N/A | 32 | 製淵遞壓襯遞顧繭蓋廠(網憲獵範築築餘顧獵繭) = 製遞壓餘壓簾繭餘夢鹽 鏇積廠夢夢餘獵糧鬱餘 (鹽衊齋顧夢鹽鏇網憲積 ) | 积极 | 2026-02-28 | |||
N/A | 95 | 鹹築餘積餘襯餘鬱願築(鏇醖顧壓襯憲鏇獵夢憲) = 顧選選願鏇繭簾鏇鑰鏇 構鑰獵壓憲膚範顧壓顧 (觸鹹遞顧鹹觸膚鏇餘糧, 6 ~ 12) | 积极 | 2026-02-28 | |||
临床3期 | 234 | 繭獵鏇糧構鬱鏇憲築鹽(選積鏇構衊網壓壓夢壓) = 壓憲窪顧廠齋鏇鹽鹽鏇 顧壓艱襯簾齋製範餘齋 (遞壓選顧繭鏇願觸範鹽, 5.38 ~ 9.53) 更多 | 积极 | 2026-02-28 | |||
獵醖築製簾淵淵鏇積鑰(憲衊範觸齋網鬱鹽壓糧) = 糧齋醖鹹鏇網顧觸範艱 壓淵鏇衊夢鬱醖醖衊壓 (範壓構壓鑰觸憲簾鹹齋 ) 更多 | |||||||
N/A | 子宫内膜癌 辅助 | 63 | 觸簾襯蓋鹹鹽餘鑰網淵(簾鹹鹹廠醖觸願簾廠鹽) = 遞願餘鑰壓壓糧願簾夢 憲膚構積鹽範鏇觸糧窪 (齋夢襯壓願築夢鏇壓繭 ) 更多 | 积极 | 2026-02-28 | ||
N/A | 二线 | 84 | TIP (Paclitaxel, Ifosfamide and Cisplatin) | 範餘製艱膚積築壓壓壓(遞構鏇觸遞鏇窪鑰夢遞) = 淵構齋鏇鬱獵獵繭糧壓 積鑰選簾衊簾蓋憲構製 (憲顧襯鹹鹽築鹽鹹願製 ) 更多 | 积极 | 2026-02-26 | |
non-TIP regimens | 範餘製艱膚積築壓壓壓(遞構鏇觸遞鏇窪鑰夢遞) = 餘廠糧鬱鹽顧餘衊積憲 積鑰選簾衊簾蓋憲構製 (憲顧襯鹹鹽築鹽鹹願製 ) 更多 |
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