Bupivacaine liposome

-- Studies highlight reduced total cost of care and select healthcare resource utilization outcomes in total knee arthroplasty (TKA) and spinal fusion -- BRISBANE, Calif., March 30, 2026 (GLOBE NEWSWIRE) -- Pacira BioSciences, Inc. (NASDAQ: PCRX), the industry leader in its commitment to deliver innovative, non-opioid pain therapies to transform the lives of patients, today announced findings from two real-world studies evaluating the economic benefits of EXPAREL ® (bupivacaine liposome injectable suspension) in orthopaedic procedures, including total knee arthroplasty (TKA) and spinal fusion. In both studies, EXPAREL was associated with lower total cost of care compared with ropivacaine in one study and standard of care options (non-LB) in the other, with reductions observed in both outpatient and inpatient surgical settings. The data will be presented at the Orthopaedic Research Society (ORS) 2026 Annual Meeting taking place March 27–31 in Charlotte, North Carolina. Briefly, the analyses include two propensity score-matched cohort studies evaluating outcomes on surgery day and throughout 30 days of follow-up in commercial and Medicare Advantage populations. Across both studies, EXPAREL was associated with lower total costs and reductions in select healthcare resource utilization measures. In the spinal fusion study, these reductions were driven primarily by a shorter length of hospital stay. “Pacira is committed to advancing the economic understanding of postsurgical pain management through real-world evidence that demonstrates the value of non-opioid approaches,” said Jonathan Slonin, MD, MBA, Chief Medical Officer at Pacira BioSciences. “These findings reinforce the role of EXPAREL within multimodal pain management strategies and underscore its potential to improve patient outcomes while removing economic barriers to access.” Pacira Presentations at ORS 2026: “Costs and Health Care Resource Utilization of Liposomal Bupivacaine and Ropivacaine in the Total Knee Arthroplasty in the Hospital Outpatient Department: a Propensity Score-Matched Cohort Study” Presenter: Jennifer Lin, Senior Director, Epidemiology in Health Outcomes Economics Research & RWE Department, Pacira BioSciences Poster Number : 1224 Date & Time: Monday, March 30, 4:45–5:30 p.m. ET This study evaluated real-world outcomes of liposomal bupivacaine (LB) compared with ropivacaine in patients undergoing TKA in the HOPD setting, with a focus on healthcare resource utilization and total cost of care on surgery day and during the subsequent 30 days of follow-up. In a propensity score-matched analysis of commercial and Medicare Advantage populations (in the commercial cohort, there were 9463 patients each in the LB and ropivacaine group; for the MA cohort, there were 2924 patients in each group), LB was associated with significantly lower total costs versus ropivacaine (commercial: −$409 [$37,466 vs $37,875]; Medicare Advantage: −$1,359 [$19,814 vs $21,173]; P<0.001 for all), as well as lower index procedure costs (commercial: −$328 [$33,539 vs $33,867]; Medicare Advantage: −$781 [$16,693 vs $17,474]; P<0.0001 for all). Additional findings included reduced home health utilization in both cohorts for LB (P<0.001) and reduced inpatient admissions in the commercial population (P<0.05), alongside lower outpatient, pharmacy, and home health costs (P<0.05 for all). Lower Costs and Health Care Resource Utilization of Patients Undergoing Spinal Fusion Treated With Liposomal Bupivacaine in the Inpatient Commercial Setting: a Propensity Score-Matched Cohort Presenter: Jennifer Lin, Senior Director, Epidemiology in Health Outcomes Economics Research & RWE Department, Pacira BioSciences Poster Number : 1798 Date & Time: Monday, March 30, 4:45–5:30 p.m. ET This study evaluated real-world economic and healthcare resource utilization outcomes of LB compared with non-LB analgesia in commercially insured patients undergoing spinal fusion surgery in the inpatient setting on surgery day and over subsequent 30-day episode of care. In a propensity score-matched cohort (n=478 LB; n=1,434 non-LB), LB use was associated with significantly lower mean total costs (−$5,993.17 [$75,703.78 vs $81,696.95]; P<0.05), driven primarily by reductions in total medical cost (−$6,001.19; P<0.05), with additional decreases in outpatient costs (P<0.05). LB-treated patients also experienced a significantly shorter length of stay (−1.83 days [2.56 vs 4.39]; P<0.0001), with no differences in emergency department visits or inpatient readmissions, and a small increase in outpatient visits (0.31; P<0.001). About Pacira Pacira BioSciences delivers innovative, non-opioid pain therapies to transform the lives of patients. Pacira has three commercial-stage non-opioid treatments: EXPAREL® (bupivacaine liposome injectable suspension), a long-acting local analgesic currently approved for infiltration, fascial plane block, interscalene brachial plexus nerve block in adults, sciatic nerve block in the popliteal fossa in adults, and adductor canal block in adults for postsurgical pain management; ZILRETTA® (triamcinolone acetonide extended-release injectable suspension), an extended-release, intra-articular injection indicated for the management of osteoarthritis knee pain; and iovera®°, a novel, handheld device for delivering immediate, long-acting, drug-free pain control using precise, controlled doses of cold temperature to a targeted nerve. The company is also advancing a pipeline of clinical-stage assets for musculoskeletal pain and adjacencies, its most advanced product candidate, PCRX-201 (enekinragene inzadenovec), a novel locally administered gene therapy in Phase 2 clinical development for osteoarthritis of the knee. To learn more about Pacira, visit . About EXPAREL® (bupivacaine liposome injectable suspension) EXPAREL is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older, and postsurgical regional analgesia via an interscalene brachial plexus block in adults, a sciatic nerve block in the popliteal fossa in adults, and an adductor canal block in adults. The safety and effectiveness of EXPAREL have not been established to produce postsurgical regional analgesia via other nerve blocks besides an interscalene brachial plexus nerve block, a sciatic nerve block in the popliteal fossa, or an adductor canal block. The product combines bupivacaine with multivesicular liposomes, a proven product delivery technology that delivers medication over a desired time period. EXPAREL represents the first and only multivesicular liposome local anesthetic that can be utilized in the peri- or postsurgical setting. By utilizing the multivesicular liposome platform, a single dose of EXPAREL delivers bupivacaine over time, providing significant reductions in cumulative pain scores with up to a 78 percent decrease in opioid consumption; the clinical benefit of the opioid reduction was not demonstrated. Additional information is available at . Important Safety Information about EXPAREL for Patients EXPAREL should not be used in obstetrical paracervical block anesthesia. In studies in adults where EXPAREL was injected into a wound, the most common side effects were nausea, constipation, and vomiting. In studies in adults where EXPAREL was injected near a nerve, the most common side effects were nausea, fever, headache, and constipation. In the study where EXPAREL was given to children, the most common side effects were nausea, vomiting, constipation, low blood pressure, low number of red blood cells, muscle twitching, blurred vision, itching, and rapid heartbeat. EXPAREL can cause a temporary loss of feeling and/or loss of muscle movement. How much and how long the loss of feeling and/or muscle movement depends on where and how much of EXPAREL was injected and may last for up to 5 days. EXPAREL is not recommended to be used in patients younger than 6 years old for injection into the wound, for patients younger than 18 years old for injection near a nerve, and/or in pregnant women. Tell your health care provider if you or your child has liver disease, since this may affect how the active ingredient (bupivacaine) in EXPAREL is eliminated from the body. EXPAREL should not be injected into the spine, joints, or veins. The active ingredient in EXPAREL can affect the nervous system and the cardiovascular system; may cause an allergic reaction; may cause damage if injected into the joints; and can cause a rare blood disorder. Forward-Looking Statements Any statements in this press release about Pacira’s future expectations, plans, trends, outlook, projections and prospects, and other statements containing the words “believes,” “anticipates,” “plans,” “estimates,” “expects,” “intends,” “may,” “will,” “would,” “could,” “can” and similar expressions, constitute forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the Private Securities Litigation Reform Act of 1995, including, without limitation, statements related to: the contributions of new directors; '5x30', our growth and business strategy, our future outlook, the strength and efficacy of our intellectual property protection and patent terms, our future growth potential and future financial and operating results and trends, our plans, objectives, expectations (financial or otherwise) and intentions, including our plans with respect to the repayment of our indebtedness, anticipated product portfolio and product development programs, strategic alliances, plans with respect to the Non-Opioids Prevent Addiction in the Nation (“NOPAIN”) Act and any other statements that are not historical facts. For this purpose, any statement that is not a statement of historical fact should be considered a forward-looking statement. We cannot assure you that our estimates, assumptions and expectations will prove to have been correct. Actual results may differ materially from these indicated by such forward-looking statements as a result of various important factors, including risks relating to, among others: risks associated with acquisitions, such as the risk that the acquired businesses and/or assets will not be integrated successfully, that such integration may be more difficult, time-consuming or costly than expected or that the expected benefits of the transaction will not occur; our manufacturing and supply chain, global and United States economic conditions (including tariffs, inflation and rising interest rates), and our business, including our revenues, financial condition, cash flows and results of operations; the success of our sales and manufacturing efforts in support of the commercialization of EXPAREL, ZILRETTA and iovera°; the rate and degree of market acceptance of EXPAREL, ZILRETTA and iovera°; the size and growth of the potential markets for EXPAREL, ZILRETTA and iovera° and our ability to serve those markets; our plans to expand the use of EXPAREL, ZILRETTA and iovera° to additional indications and opportunities, and the timing and success of any related clinical trials for EXPAREL, ZILRETTA, iovera° and any of our other product candidates, including but not limited to PCRX-201; the commercial success of EXPAREL, ZILRETTA and iovera°; the related timing and success of United States Food and Drug Administration supplemental New Drug Applications and premarket notification 510(k)s; the related timing and success of European Medicines Agency Marketing Authorization Applications; our plans to evaluate, develop and pursue additional product candidates utilizing our proprietary multivesicular liposome (“pMVL”) drug delivery technology or our proprietary high-capacity adenovirus (“HCAd”) vector platform; the approval of the commercialization of our products in other jurisdictions (by either us or our partners); clinical trials in support of an existing or potential pMVL- or HCAd-based product; our commercialization and marketing capabilities; our ability to successfully complete capital projects; the outcome of any litigation; the recoverability of our deferred tax assets; assumptions associated with contingent consideration payments; assumptions used for estimated future cash flows associated with determining the fair value of the company; the anticipated funding or benefits of our share repurchase program; and factors discussed in the “Risk Factors” of our most recent Annual Report on Form 10-K and in other filings that we periodically make with the Securities and Exchange Commission (the “SEC”). In addition, the forward-looking statements included in this press release represent our views as of the date of this press release. Important factors could cause actual results to differ materially from those indicated or implied by forward-looking statements, and as such we anticipate that subsequent events and developments will cause our views to change. Except as required by applicable law, we undertake no intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, and readers should not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release. These forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from those expressed or implied by these statements. These factors include the matters discussed and referenced in the “Risk Factors” of our most recent Annual Report on Form 10-K and in other filings that we periodically make with the SEC. CONTACT: Investor Contact: Susan Mesco, (973) 451-4030 susan.mesco@pacira.com Media Contact: Kim Hamilton, (908) 721-7067 kim.hamilton@pacira.com

Lanifibranor（拉尼兰诺）片是一款由法国Inventiva公司研发的口服泛PPAR激动剂，目前全球尚未正式上市，正处于NASH适应症III期临床关键阶段。 基本信息 通用名：Lanifibranor（拉尼兰诺） 药物类别：泛PPAR受体激动剂（均衡激活PPARα/δ，部分激活PPARγ） 研发公司：Inventiva（法国） 中国权益：正大天晴（中国生物制药）于2022年9月获得大中华区（大陆、港澳台）开发、生产、商业化权益 主要适应症：非酒精性脂肪性肝炎（NASH/MASH）（伴有肝纤维化） 剂型规格：400mg片剂（每日一次口服） 作用机制与临床优势 三重作用机制 PPARα：调节脂质代谢，降低肝脏脂肪（ steatosis） PPARγ：抗炎、改善胰岛素抵抗 PPARδ：抗纤维化、改善线粒体功能 IIb期（NATIVE）关键结果（发表于NEJM） NASH逆转且纤维化不恶化：49%（安慰剂29%） 纤维化改善≥1期且NASH不恶化：42%（安慰剂24%） 同时改善：转氨酶、血糖、血脂、胰岛素抵抗 安全性：耐受性好，主要为轻度胃肠道反应 上市情况 Lanifibranor（拉尼兰诺） 是目前全球NASH领域进度最领先的口服泛 PPAR激动剂，也是首个在II期同时显著改善NASH与肝纤维化的药物。全球尚未上市，中美欧均处于III期关键阶段；中国由正大天晴主导开发，已获突破性治疗认定。 美国FDA：已授予突破性疗法认定（BTD）+快速通道资格；关键III期试验NATiV3正在进行中（针对F2/F3期肝纤维化NASH）。 欧盟EMA：已获 优先药物资格（PRIME）；同步推进III期与上市准备。 中国（NMPA）注册申报情况： 2023年3月临床申请获受理；2023年7月拟纳入突破性治疗药物程序。 临床试验情况 专利情况 Lanifibranor（拉尼兰诺）由法国Inventiva公司拥有全球核心专利，专利壁垒极强，核心化合物专利至2039年到期。中国由正大天晴获得独家授权。 核心化合物专利： 基础专利WO2007026097（PCT）；中国同族专利CN101277919B 专利权人：Inventiva S.A.（法国） 申请日：2006年8月8日 到期日：2026年8月7日 各国调整后到期日：2039年11月8日（美/欧/日/中，含期限调整） 保护化合物、晶型、盐、水合物、制备方法、所有适应症（NASH/MASH、纤维化、肝硬化、代谢疾病）、制剂、联合用药。 专利号：CN101277919B 保护Lanifibranor化合物、药用盐、异构体。 申请日：2006-08-08 授权日：2010-06-02 法定到期日：2026-08-07 调整后到期日：2039-11-08（含专利期限补偿PTE） 晶型专利：CN117794926A（2024 公开，Inventiva） 保护多种晶型、制备、用途（NASH）。 用途专利：CN101848690B 保护治疗NASH、肝纤维化、肝硬化。 制剂专利：CN107277396B 保护400mg片剂、缓释制剂、每日一次方案。 联合用药专利：CN110547695A 保护与GLP-1、FXR激动剂联用。 专利壁垒 极高壁垒，仿制药极难突破： 多层保护：化合物 → 晶型 → 制剂 → 用途 → 联合用药 超长保护期：核心至2039年，外围至2045年+ 中国授权稳固：正大天晴获完整专利实施权 侵权风险： 任何厂家2039年前生产、进口Lanifibranor均侵权； 规避设计难度大（PPAR 泛激动剂结构特异性强）。 其他药品分享链接如下，欢迎点击查看： Ormeloxifene OTF慢性体重管理的新型药物-Tirzepatide新型的非阿片类小分子镇痛药-Suzetrigine奥麦利昔芬口腔薄膜立项调研报告纳米技术双氯芬酸乳胶剂药学研究2025年9月药品批准信息快讯（八）——利斯的明透皮贴剂分享2025年9月药品批准信息快讯（九）——米托坦片分享CDE-《化学仿制药参比制剂目录（第一百批）》（征求意见稿）[附: 药品分享——阿达苏(洛沙平吸入剂)]药品分享-塞来昔布盐酸曲马多片药品分享——伐莫洛龙口服混悬液【药品分享】盐酸菲优拉生片【药品分享】拉坦噻吗滴眼液【药品分享】Baxdrostat 片【药品分享】Omecamtiv Mecarbil缓释片【药品分享】曲地匹坦（Rolapitant）【药品分享】Zasocitinib 胶囊【药品分享】甲磺酸阿帕替尼片【药品分享】巴氯芬口服溶液【药品分享】奥德昔巴特胶囊【药品分享】扎维吉泮鼻喷雾剂【药品分享】左羟丙哌嗪糖浆【药品分享】利丙双卡因凝胶贴膏【药品分享】司来吉兰改良型新药（缓释片）【药品分享】复方甘菊利多卡因凝胶【药品分享】盐酸索安非托片【药品分享】地塞米松口溶膜【药品分享】盐酸来罗西利片【药品分享】马来酸噻吗洛尔凝胶【药品分享】褪黑素颗粒【药品分享】罗氟司特乳膏【药品分享】盐酸芬戈莫德胶囊【药品分享】示踪用盐酸米托蒽醌注射液【药品分享】美洛昔康纳米晶注射液【药品分享】Clascoterone 5%外用溶液【药品分享】马来酸依那普利口服溶液【药品分享】注射用双氯芬酸钠利多卡因【药品分享】马来酸依那普利叶酸片—复方降压药【药品分享】依曲帕米鼻喷雾剂—用于治疗成人阵发性室上性心动过速的可自行给药鼻喷雾剂【药品分享】奥卡西平口服混悬液—一款可用于儿童的钠通道调节类抗癫痫药【药品分享】泊沙康唑口服混悬液——一种常用的抗真菌药物【药品分享】舒沃替尼片【药品分享】依伏卡塞片——第二代口服拟钙剂【药品分享】西诺氨酯片——第三代抗癫痫发作药物【药品分享】匹妥布替尼片——非共价可逆 BTK 抑制剂（用于复发 / 难治套细胞淋巴瘤（MCL））【药品分享】贝美前列素【产品分享】达普司他片 【药品分享】水合氯醛糖浆——镇静催眠药 【产品分享】苏沃雷生（Suvorexant）——全球首个食欲素受体拮抗剂类催眠药 【药品分享】贝沙罗汀 【药品分享】地夫可特干混悬剂——一种糖皮质激素类药物 【药品分享】伊卢多啉片——治疗成人腹泻型肠易激综合征（IBS‑D）的首创口服阿片受体调节剂 【药品分享】卢美哌隆胶囊——一种新型的非典型抗精神病药物 【药品分享】奥氟格列隆片——口服非肽类小分子 GLP-1 受体激动剂 【药品分享】苯磺酸克利加巴林胶囊——一种新型的治疗神经病理性疼痛的药物 【药品分享】苯磺酸美洛加巴林片——治疗周围神经病理性疼痛（PNP）的第三代钙离子通道调节剂 【药品分享】Iberdomide胶囊——一款新一代cereblon（CRBN）E3连接酶调节剂（CELMoD）化合物 【药品分享】酒石酸伐尼克兰鼻喷雾剂——一种用于治疗干眼症的西药 【药品分享】赛沃替尼片——中国首个获批的高选择性 MET 酪氨酸激酶抑制剂 【药品分享】盐酸阿夫唑嗪缓释片——一种用于治疗良性前列腺增生（BPH） 的 α1 - 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