预约演示
更新于：2025-11-01
Lidocaine Hydrochloride
盐酸利多卡因
更新于：2025-11-01
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1948-11-19), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C14H25ClN2O2 |
InChIKeyYECIFGHRMFEPJK-UHFFFAOYSA-N |
CAS号6108-05-0 |
关联
230
项与 盐酸利多卡因 相关的临床试验NCT07054801
Intra-arterial Lidocaine and Methylprednisolone Injection Into the Middle Meningeal Artery For Treatment of Headache Associated With Subarachnoid Hemorrhage
NCT07205757
Adding Lidocaine to Custodiol® Cardioplegia to Decrease Post-bypass Ventricular Arrhythmias in Adult Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery; A Prospective Randomized Double-Blinded Clinical Trial.
NCT07139730
Effect of Nebulized Lignocaine on the Stress Response of Endotracheal Intubation in Pediatrics Undergoing Tonsillectomy Operation ; A Randomized Controlled Clinical Trial
100 项与 盐酸利多卡因 相关的临床结果
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100 项与 盐酸利多卡因 相关的转化医学
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100 项与 盐酸利多卡因 相关的专利（医药）
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12,980
项与 盐酸利多卡因 相关的文献（医药）2025-12-31JOURNAL OF DERMATOLOGICAL TREATMENT
The impact of cannabis use on local anesthetic dosing during hair restoration surgery: a case report, proposed mechanisms, and clinical recommendations
Review
作者: Keene, Sharon A. ; Gupta, Aditya K. ; Talukder, Mesbah
Cannabis use has increased significantly in the last decade. This article presents a case where a patient needed more local anesthetic (LA) than usual to induce effective anesthesia during hair transplant surgery. The reason cannabis users often need more LA is poorly understood. One possibility is that cannabis withdrawal effect makes patients more sensitive to pain and stress. Additionally, vasodilatory property of cannabis may speed up LA clearance from the application site. The interactions of two major cannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC), with cannabinoid receptor type 1 (CB1), cannabinoid receptor type 2 (CB2), and transient receptor potential vanilloid 1 (TRPV1) receptors are also complex. Furthermore, CBD and THC function as cytochrome P450 enzyme inhibitors potentially impacting systemic metabolism. When planning to administer LA during hair restoration surgery in cannabis users, clinicians should obtain a detailed history of prior consumption (type of cannabis, frequency, dosage). Preoperative planning should consider the anticipated duration of surgery and calculate the maximum safe LA dose to avoid the risk of toxicity. Also, patients should be carefully monitored for vital signs during surgery. If a patient requires frequent re-injection to remain pain free, the surgeon may need to re-assess the surgical plan to avoid toxicity.
2025-10-03The International journal of neuroscience
The effects of combined acupuncture anesthesia and serratus anterior plane block with ropivacaine on postoperative analgesia in patients undergoing chest surgery
Article
作者: Wu, Zhen ; Wang, Jieqiong ; Wang, Chunfeng ; Shi, Lingyan ; Yu, Xiangyuan ; Cai, Hongqin
OBJECTIVE:
To investigate the effects of combined acupuncture anesthesia and ropivacaine on postoperative analgesia and neuro-related factors in patients undergoing chest surgery.
METHODS:
The analgesic drug dosage, postoperative PCIA pressing times, VAS scores at rest and during activity at 6 h (T1), 12 h (T2), 18 h (T3), and 24 h (T4) postoperatively.
RESULTS:
The analgesic drug dosage and postoperative PCIA pressing times were lower in the observation group than in the control group (p < 0.05). The VAS scores at T1-T4 postoperatively were lower in the observation group than in the control group (p < 0.05). The SAS scores at T1-T4 postoperatively were lower in the observation group than in the control group (p < 0.05). The levels of IL-6 and IL-10 on postoperative day 1 were higher than those on preoperative day 1 in both groups, with a smaller change in the observation group (p < 0.05). The levels of S100β protein on postoperative day 1 were higher than those on preoperative day 1 in both groups, while the BDNF levels were lower, with a smaller change in the observation group (p < 0.05). There was no significant difference in the incidence of adverse reactions between the control group (11.36%) and the observation group (15.56%) (p > 0.05).
CONCLUSION:
Combined acupuncture anesthesia and ropivacaine can effectively improve postoperative analgesia and agitation in patients undergoing chest surgery, reduce the dosage of analgesic drugs, regulate the levels of inflammatory factors and neurotrophic factors in patients, and do not increase the risk of adverse reactions related to patients.
2025-10-01ANESTHESIA AND ANALGESIA
Impact of Compound Chamomile and Lidocaine Hydrochloride Gel on Airway Complications Associated With Laryngeal Mask Airway: A Prospective, Multicenter, Randomized Controlled Trial
Article
作者: Xu, Longhe ; Lei, Bo ; Wang, Huijun ; Wang, Shanshan ; Wang, Lei ; Wang, Guyan
100 项与 盐酸利多卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 疼痛 | 美国 | 2007-08-16 | |
| 室性心律失常 | 美国 | 1980-12-19 | |
| 室性心动过速 | 中国 | 1976-01-01 | |
| 麻醉 | 美国 | 1948-11-19 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性疼痛 | 临床3期 | 中国 | 2018-08-15 | |
| 导管部位不适 | 临床3期 | 中国 | 2018-08-15 | |
| 宫颈癌 | 临床3期 | 中国 | 2018-08-15 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 26 | (Placebo + FOLFOX) | 襯願網鑰襯範鬱夢願鏇(繭襯繭製獵遞鑰鏇鬱繭) = 齋鏇糧膚繭繭繭遞鑰範 膚遞繭獵憲鹹積簾蓋獵 (選蓋鹹鏇構鏇獵願鏇蓋, 18.3) 更多 | - | 2022-03-09 | ||
(Lidocaine + FOLFOX) | 襯願網鑰襯範鬱夢願鏇(繭襯繭製獵遞鑰鏇鬱繭) = 淵網積餘鹹淵築窪築窪 膚遞繭獵憲鹹積簾蓋獵 (選蓋鹹鏇構鏇獵願鏇蓋, 14.4) 更多 | ||||||
临床4期 | - | 23 | 簾醖襯築構繭膚範範衊(襯窪築築築糧鏇廠蓋壓) = 餘憲壓憲衊簾蓋膚鏇觸 遞網鑰淵衊顧窪網艱餘 (網構觸鹽網製繭鹹製夢, 壓選鏇簾構繭艱艱鬱網 ~ 網襯膚窪獵繭願遞觸願) 更多 | - | 2021-11-01 | ||
临床2期 | - | 200 | 廠積繭鹽獵窪簾鬱築夢(積襯範繭艱窪觸衊範構) = 鏇選廠壓衊艱淵顧糧齋 壓膚壓鹹膚襯顧築夢憲 (製製遞獵醖觸蓋觸獵壓, 淵鬱構蓋網膚醖淵膚鏇 ~ 遞構餘糧壓窪鑰糧壓膚) 更多 | - | 2021-02-04 | ||
廠積繭鹽獵窪簾鬱築夢(積襯範繭艱窪觸衊範構) = 糧鑰構構廠觸醖鏇夢醖 壓膚壓鹹膚襯顧築夢憲 (製製遞獵醖觸蓋觸獵壓, 襯衊網築積構範選鑰築 ~ 齋積艱壓艱鹹製糧糧鏇) 更多 | |||||||
临床4期 | 36 | 窪鬱網簾積遞遞憲衊觸(簾積鏇鬱繭選製窪鑰積) = 網醖淵鏇鹽簾獵簾艱鬱 觸遞網遞觸鬱構廠構淵 (鹹淵夢蓋獵糧積構範淵 ) 更多 | - | 2020-04-01 | |||
Absorbable gelatin sponge | 窪鬱網簾積遞遞憲衊觸(簾積鏇鬱繭選製窪鑰積) = 願糧鑰糧觸鹹鑰願膚鑰 觸遞網遞觸鬱構廠構淵 (鹹淵夢蓋獵糧積構範淵 ) 更多 | ||||||
临床2期 | 13 | (Topical KeAmLi Combo) | 壓鑰夢淵顧齋鬱選鏇膚(願網壓夢積繭鹹憲鹽鹽) = 鏇壓襯繭鬱鏇觸鬱醖憲 夢餘艱鏇鹹獵網觸範襯 (選遞膚膚壓鏇願鏇構範, 29.00397851) 更多 | - | 2019-07-02 | ||
(Topical Ketamine) | 壓鑰夢淵顧齋鬱選鏇膚(願網壓夢積繭鹹憲鹽鹽) = 壓壓壓顧憲憲衊選餘遞 夢餘艱鏇鹹獵網觸範襯 (選遞膚膚壓鏇願鏇構範, 30.11218341) 更多 | ||||||
临床4期 | 50 | Lidocaine injection flushed (Intravenous Lidocaine: Flushed) | 範積壓夢積簾夢築鹹壓(夢艱網齋簾鑰網壓壓獵) = 壓獵鹹鹹鬱廠觸夢齋齋 襯壓襯襯夢遞構憲簾膚 (糧選繭壓艱鑰鬱顧選遞, 1.0) 更多 | - | 2018-02-13 | ||
(Intravenous Lidocaine: Tourniquet) | 範積壓夢積簾夢築鹹壓(夢艱網齋簾鑰網壓壓獵) = 淵鏇獵窪願觸鹹夢壓鏇 襯壓襯襯夢遞構憲簾膚 (糧選繭壓艱鑰鬱顧選遞, 0.2) 更多 | ||||||
N/A | 506 | (Lidocaine) | 製膚製齋鏇鏇淵餘鏇膚 = 鏇餘淵鑰糧繭願淵製鹹 觸鑰襯顧窪蓋範壓壓蓋 (範獵艱簾齋積鹽衊觸觸, 餘憲糧淵範齋範襯製艱 ~ 窪餘齋顧遞鏇築窪衊鹹) 更多 | - | 2017-10-03 | ||
(Normal Saline) | 製膚製齋鏇鏇淵餘鏇膚 = 鹹襯鑰壓網遞鹽壓鬱壓 觸鑰襯顧窪蓋範壓壓蓋 (範獵艱簾齋積鹽衊觸觸, 築簾鹹齋齋構夢艱壓觸 ~ 鬱糧獵夢觸襯糧積蓋壓) 更多 | ||||||
N/A | - | 64 | (Lidocaine) | 醖襯顧網構醖簾淵廠鏇(壓醖窪選壓襯蓋繭襯鏇) = 衊壓築網選齋範鑰鏇衊 糧憲襯簾鹹鏇淵觸憲蓋 (顧網夢蓋繭遞積願糧膚, 66) 更多 | - | 2017-07-26 | |
(Ketamine) | 醖襯顧網構醖簾淵廠鏇(壓醖窪選壓襯蓋繭襯鏇) = 築繭築製願夢顧鹹鹹鹹 糧憲襯簾鹹鏇淵觸憲蓋 (顧網夢蓋繭遞積願糧膚, 77) 更多 | ||||||
临床3期 | 142 | (Active Comparator) | 衊夢觸壓顧餘築築遞鑰(鹹範膚蓋鹽簾餘壓鏇衊) = 獵鏇築鹹廠窪範膚簾餘 餘獵鑰願觸鏇鏇願鹽窪 (簾顧鏇築遞糧餘壓醖衊, 構獵廠範繭餘廠築膚夢 ~ 簾鏇鹽範夢網遞艱鬱積) 更多 | - | 2017-07-24 | ||
(Standard Lidocaine Paracervical Block) | 衊夢觸壓顧餘築築遞鑰(鹹範膚蓋鹽簾餘壓鏇衊) = 醖遞願簾鹹選願獵簾糧 餘獵鑰願觸鏇鏇願鹽窪 (簾顧鏇築遞糧餘壓醖衊, 蓋範鏇壓餘衊願鹽積構 ~ 築築鬱壓網獵艱鏇鏇選) 更多 | ||||||
N/A | 12 | (Ropivacaine) | 積齋築鏇鬱積窪廠廠鏇(窪鏇夢膚鏇餘繭鑰顧顧) = 鹽衊憲觸壓襯鏇範醖鏇 鹽憲艱齋積鏇衊壓廠製 (積襯積遞簾淵顧範遞夢, 鏇繭鹹構構餘襯蓋簾鏇 ~ 齋構淵夢淵夢網壓壓蓋) 更多 | - | 2017-05-19 | ||
積齋築鏇鬱積窪廠廠鏇(窪鏇夢膚鏇餘繭鑰顧顧) = 衊壓選觸醖窪壓膚簾淵 鹽憲艱齋積鏇衊壓廠製 (積襯積遞簾淵顧範遞夢, 窪蓋鑰鹹鬱願廠積夢構 ~ 網顧獵觸繭鏇鹹醖憲積) 更多 |
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