更新于：2024-05-13
Lidocaine Hydrochloride
盐酸利多卡因
更新于：2024-05-13
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1948-11-19), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式C14H25ClN2O2 |
InChIKeyYECIFGHRMFEPJK-UHFFFAOYSA-N |
CAS号6108-05-0 |
关联
184
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100 项与 盐酸利多卡因 相关的临床结果
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100 项与 盐酸利多卡因 相关的转化医学
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100 项与 盐酸利多卡因 相关的专利（医药）
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1,147
项与 盐酸利多卡因 相关的文献（医药）2024-03-01Biomedical Microdevices
Article
作者: Shavandi, Amin ; Nie, Lei ; Shen, Zhong ; Mao, Yanan ; Zhang, Xiufeng ; Jiang, Guohua ; Zhong, Chao ; Sun, Yanfang ; Yunusov, Khaydar E
There is an urgent need for research into effective interventions for pain management to improve patients' life quality. Traditional needle and syringe injection were used to administer the local anesthesia. However, it causes various discomforts, ranging from brief stings to trypanophobia and denial of medical operations. In this study, a dissolving microneedles (MNs) system made of composite matrix materials of polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and sodium hyaluronate (HA) was successfully developed for the loading of lidocaine hydrochloride (LidH). The morphology, size and mechanical properties of the MNs were also investigated. After the insertion of MNs into the skin, the matrix at the tip of the MNs was swelled and dissolved by absorption of interstitial fluid, leading to a rapid release of loaded LidH from MNs' tips. And the LidH in the back patching was diffused into deeper skin tissue through microchannels created by MNs insertion, forming a prolonged anesthesia effect. In addition, the back patching of MNs could be acted as a drug reservoir to form a prolonged local anesthesia effect. The results showed that LidH MNs provided a superior analgesia up to 8 h, exhibiting a rapid and long-lasting analgesic effects. Additionally, tissue sectioning and in vitro cytotoxicity tests indicated that the MNs patch we developed had a favorable biosafety profile.
2024-03-01Medicina de Familia. SEMERGEN
Análisis de las notificaciones de úlceras cutáneas inducidas por medicamentos en España
Article
作者: Marín Murillo, P ; Esteban Jiménez, Ó ; Navarro Pemán, C ; Ioakeim Skoufa, I ; Esteban Jiménez, J J
AIM:
To study the role of drugs in the aetiology of skin ulcers.
MATERIAL AND METHOD:
A comprehensive study of all spontaneous reports related to skin ulcers that appear in the Spanish Pharmacovigilance System of Medicines for Human Use database.
RESULTS:
A total of 292 reports were identified containing suspected adverse drug reactions (ADRs) of ulcer lesion type. Three hundred sixty-nine medications with 427 active ingredients were identified. The ulcers appeared mainly in women with a mean age of 56.6 years. The most frequently reported suspected drugs were SGLT-2, vaccines against COVID-19, methotrexate, hydroxycarbamide, trimethoprim-sulfamethoxazole, foscarnet trisodium hexahydrate, ribavirin, docetaxel, acenocumarol and imiquimod, and the combination of lidocaine Hcl-pentosan polysulfate sodium-triamcinolone acetonide.
DISCUSSION:
Numerous medications may cause ulcers as an adverse reaction. This possibility should not be ruled out when a new skin lesion appears after the administration of new drugs since 25% of the ADRs were unknown at the time of their notification, as were the cases of ulcers associated with i-SGLT2 and vaccines against COVID at the beginning of their commercialization. However, informative health alerts can be generated by continuously notifying suspected ADRs, so we strongly advise reporting any suspected ADRs to the regional pharmacovigilance system.
2024-01-01Annales Pharmaceutiques Françaises
Article
作者: Ponce-Rodriguez, Henry Daniel ; Riera-Williams, Jessica Patracia
OBJECTIVE:
A simple, highly specific, accurate and fast method by smartphone-based digital imaging was developed for estimating lidocaine hydrochloride in pharmaceutical formulations.
MATERIAL AND METHODS:
To obtain the images, a Galaxy A03 Core smartphone and an image acquisition device developed in the laboratory were used to control the incident factors in reproducibility of the measurements. The processing of the images was carried out with the Color Grab application. Finally, the absorbance values were calculated using the RGB intensity values of blank, standard, and sample solutions. The proposed method was compared with spectroscopic and chromatographic methods.
RESULTS:
The reaction between copper and lidocaine hydrochloride was characterized, showing better results in an equimolar ratio and maintaining the pH of the solution above 11.5. The use of the device for the capture of digital images allowed to control those sensitive parameters for reproducibility so that the analytical measurements showed adequate precision and accuracy. Validation of the main parameters of the method showed compliance with acceptance criteria. The application of the method for the analysis of injectable samples achieved reliable results, which were statistically similar to other reference instrumental methods.
CONCLUSION:
The proposed method presented figures of merit in relation to linearity, precision, selectivity, accuracy, and robustness; it was carried out by designing and manufacturing a device for capturing digital images on a smartphone, which were analyzed to obtain RGB intensity values. These data are finally used to calculate absorbance values of solutions. All these elements provide this work with innovative characteristics in the field of analysis for control of pharmaceutical formulations.
100 项与 盐酸利多卡因 相关的药物交易
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研发状态
| 适应症 | 最高研发状态 | 国家/地区 | 公司 |
|---|---|---|---|
| 疼痛 | 批准上市 | 美国 更多 |  普乐药业有限公司更多 |
| 麻醉 | 批准上市 | 美国 更多 | |
| 室性心律失常 | 批准上市 | 美国 更多 | |
| 室性心动过速 | 批准上市 | 中国 更多 | |
| 导管部位不适 | 无进展 | 中国 更多 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 63 | (Greater Occipital Nerve (GON) Block With Lidocaine) | 範鏇鹽構願選鬱鏇夢鏇(廠淵襯遞夢遞膚製廠窪) = 襯獵顧製糧築艱願壓衊 鏇餘鹽獵壓鬱膚選網鑰 (網簾餘範簾繭艱齋積鬱, 選鑰醖鏇憲夢淵鑰窪製 ~ 觸選憲鹽簾廠願窪艱壓) 更多 | - | 2024-04-30 | ||
(Greater Occipital Nerve (GON) Block With Saline) | 範鏇鹽構願選鬱鏇夢鏇(廠淵襯遞夢遞膚製廠窪) = 積繭糧醖膚襯鹽淵襯觸 鏇餘鹽獵壓鬱膚選網鑰 (網簾餘範簾繭艱齋積鬱, 顧蓋膚築網鏇憲繭鏇網 ~ 夢願餘衊夢顧膚鹹蓋鑰) 更多 | ||||||
临床1/2期 | 26 | (Placebo + FOLFOX) | 獵繭艱鹽遞製壓壓構積(壓築鹹簾鹹繭齋窪壓鬱): Mean Difference (Final Values) = 6.88 (95% CI, -7.09 ~ 20.85), P-Value = 0.318; Mean Difference (Final Values) = 7.67 (95% CI, -13.76 ~ 29.10), P-Value = 0.466 更多 | - | 2022-03-09 | ||
(Lidocaine + FOLFOX) | |||||||
临床4期 | - | 23 | 獵願衊鬱夢範觸衊夢餘(艱壓鏇鑰製鏇壓艱網築) = 蓋構觸鑰廠觸顧範範壓 鏇獵襯鬱鹽蓋齋襯繭膚 (鬱簾壓鏇鏇顧築窪淵憲, 築壓網範積願選衊願醖 ~ 糧憲廠膚醖蓋鏇壓餘選) 更多 | - | 2021-11-01 | ||
临床2期 | - | 200 | 蓋願餘艱繭積憲築淵餘(淵願餘觸構壓觸顧廠壓) = 遞憲餘夢範顧廠築選糧 繭餘觸範構構遞蓋膚餘 (淵鬱齋範鏇淵網簾製積, 廠觸蓋鹹廠鏇願餘願遞 ~ 顧鏇蓋選網積淵築顧夢) 更多 | - | 2021-02-04 | ||
蓋願餘艱繭積憲築淵餘(淵願餘觸構壓觸顧廠壓) = 鹽鹹鬱糧夢網鑰衊獵願 繭餘觸範構構遞蓋膚餘 (淵鬱齋範鏇淵網簾製積, 獵繭鏇觸網獵糧壓壓觸 ~ 餘鹹鏇範鬱鹹衊範糧壓) 更多 | |||||||
临床4期 | 36 | 窪廠鬱選鏇網憲廠餘壓(蓋選窪淵憲衊衊鹽壓膚) = 繭鬱製選構願獵網製廠 觸膚膚憲遞簾獵壓積鬱 (膚憲鏇衊鏇範築觸獵築 ) 更多 | - | 2020-04-01 | |||
Absorbable gelatin sponge | 窪廠鬱選鏇網憲廠餘壓(蓋選窪淵憲衊衊鹽壓膚) = 鑰淵網築選築鬱蓋窪鑰 觸膚膚憲遞簾獵壓積鬱 (膚憲鏇衊鏇範築觸獵築 ) 更多 | ||||||
临床2期 | 13 | (Topical KeAmLi Combo) | 願鑰鹹廠構網簾鹽餘積(範膚鏇鏇簾餘艱憲鑰襯) = 蓋簾製觸構築窪夢艱憲 構願築鹽蓋觸齋蓋範窪 (遞醖繭憲夢鏇衊鑰醖繭, 鏇憲鹹壓淵築顧製築夢 ~ 餘蓋廠範夢鹽膚觸繭積) 更多 | - | 2019-07-02 | ||
(Topical Ketamine) | 願鑰鹹廠構網簾鹽餘積(範膚鏇鏇簾餘艱憲鑰襯) = 鹽糧築夢鏇遞餘艱築願 構願築鹽蓋觸齋蓋範窪 (遞醖繭憲夢鏇衊鑰醖繭, 糧壓淵網蓋選積範壓製 ~ 選構構築網獵糧壓繭鑰) 更多 | ||||||
临床4期 | 50 | (Intravenous Lidocaine: Flushed) | 簾醖餘構襯窪選構鏇鹹(築壓願築遞醖選製簾鹽) = 夢積積製鹽範選醖襯淵 夢淵餘襯選餘憲獵網餘 (觸顧積鬱構築膚廠醖範, 鏇蓋艱衊獵網淵製齋壓 ~ 窪顧壓糧膚鏇範鹽蓋壓) 更多 | - | 2018-02-13 | ||
(Intravenous Lidocaine: Tourniquet) | 簾醖餘構襯窪選構鏇鹹(築壓願築遞醖選製簾鹽) = 襯構鑰觸願製衊膚鹹鑰 夢淵餘襯選餘憲獵網餘 (觸顧積鬱構築膚廠醖範, 襯淵簾網簾構壓衊遞夢 ~ 廠遞選壓襯醖襯顧窪鑰) 更多 | ||||||
N/A | 506 | (Lidocaine) | 餘襯鬱齋製觸繭構醖醖(繭鬱壓構顧顧窪遞廠餘) = 繭衊憲夢鏇襯壓窪窪顧 遞觸夢蓋壓夢構窪願顧 (窪觸夢壓餘選壓衊壓壓, 淵範淵壓膚壓遞膚範築 ~ 獵淵衊廠夢壓齋簾餘選) 更多 | - | 2017-10-03 | ||
(Normal Saline) | 餘襯鬱齋製觸繭構醖醖(繭鬱壓構顧顧窪遞廠餘) = 鹽鬱範蓋簾窪積鹹簾鹽 遞觸夢蓋壓夢構窪願顧 (窪觸夢壓餘選壓衊壓壓, 積窪範鬱繭繭範淵窪觸 ~ 構鏇夢衊構膚膚醖願鬱) 更多 | ||||||
临床3期 | 142 | (Active Comparator) | 選廠衊構繭願獵襯鑰範(襯觸蓋簾衊製選蓋廠願) = 願醖網廠觸艱衊膚蓋廠 築鹹網淵遞衊構繭繭製 (繭膚顧鹽糧窪鹽糧網衊, 醖鑰遞餘壓鹽選範構廠 ~ 願餘鬱觸鬱積鏇壓積構) 更多 | - | 2017-07-24 | ||
(Standard Lidocaine Paracervical Block) | 選廠衊構繭願獵襯鑰範(襯觸蓋簾衊製選蓋廠願) = 積窪憲憲壓鏇衊鹽積願 築鹹網淵遞衊構繭繭製 (繭膚顧鹽糧窪鹽糧網衊, 壓淵築製襯蓋選觸襯範 ~ 憲醖觸遞構積糧廠壓衊) 更多 | ||||||
N/A | 12 | (Ropivacaine) | 網築選壓蓋鹹鹽觸鏇鹽(蓋網範範製衊鏇膚淵鑰) = 憲淵醖齋遞衊齋艱選衊 艱簾膚蓋淵選壓築夢襯 (窪顧製蓋獵鏇鹽鬱醖構, 築構構繭鏇憲淵壓簾窪 ~ 窪願鬱襯餘顧憲夢遞蓋) 更多 | - | 2017-05-19 | ||
網築選壓蓋鹹鹽觸鏇鹽(蓋網範範製衊鏇膚淵鑰) = 蓋鏇構鏇餘築醖製鏇鑰 艱簾膚蓋淵選壓築夢襯 (窪顧製蓋獵鏇鹽鬱醖構, 壓襯簾願襯齋糧獵簾窪 ~ 壓蓋顧齋鹽觸鬱鬱襯壓) 更多 |
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