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更新于：2026-10-21
Vitamin B2
维生素B2
更新于：2026-10-21
概要
基本信息
原研机构- |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期- |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、孤儿药 (欧盟) |
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结构/序列
分子式C17H20N4O6 |
InChIKeyAUNGANRZJHBGPY-SCRDCRAPSA-N |
CAS号83-88-5 |
关联
83
项与 维生素B2 相关的临床试验CTRI/2026/03/105920
A Double Blinded Randomized Placebo Controlled Trial Evaluating the Efficacy of Riboflavin and its Association with MTHFR Gene Polymorphism in Treatment Naive Patients of Diabetic Neuropathy - NIL
ACTRN12626000204347
Effectiveness of chilled riboflavin and keratolac-soaked bandage contact lenses in reducing eye discomfort following corneal crosslinking for keratoconus
IRCT20250708066409N1
Investigating the effect of oral riboflavin on increasing corneal strength in Keratoconus patients
100 项与 维生素B2 相关的临床结果
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100 项与 维生素B2 相关的转化医学
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100 项与 维生素B2 相关的专利（医药）
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23,413
项与 维生素B2 相关的文献（医药）2027-01-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Ultra-sensitive dual-responsive Zn(II)-MOF fluorescent probe: Rapid recognition of cinoxacin and vitamin B₂ in artificial urine and saliva matrices
Article
作者: Chen, Ling ; Zhang, Ruilin ; Ma, Yulu ; Yang, Jing ; Wang, Kaimin ; Luo, Xi
This study successfully synthesized a new zinc-based metal-organic framework material {[Zn(qdda)(bpy)₀.₅]·3H₂O} (Zn-MOF) by the solvothermal method and systematically investigated its performance as a fluorescent material for the simultaneous sensing of the antibacterial drug Cinoxacin (CNX) and Vitamin B₂ (VB₂). The structure, morphology, and composition of the material were comprehensively characterized by single-crystal X-ray diffraction, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and Fourier transform infrared spectroscopy (FT-IR). Fluorescence experiments demonstrated that the Zn-MOF demonstrates significant selectivity and sensitivity toward both CNX and VB₂, with detection limits of 9.2 nM and 24 nM, separately, a rapid response (within 60 s), as well as excellent anti-interference ability and recyclability. The observed fluorescence quenching was attributed to a synergistic mechanism involving competitive absorption (CA), resonance energy transfer (RET), and photoinduced electron transfer (PET). In a simulated saliva and urine environment, the material showed satisfactory spike recovery rates for CNX and VB₂, confirming its reliability in practical sample detection. This work opens a new avenue for developing high-performance MOF-based fluorescent sensors. Such sensors show great potential for the simultaneous detection of two analytes within complex biological environments.
2027-01-01BIORESOURCE TECHNOLOGY
Biochar-based sustained coenzyme delivery for enhanced petroleum hydrocarbon biodegradation
Article
作者: Su, Yuhua ; Wu, Fei ; Fan, Kexin ; Liu, Qiyou ; Wang, Pu ; Sun, Yufeng ; Chen, Yongdong
Petroleum contamination poses a persistent threat to ecosystems and human health because of its environmental persistence and ecological toxicity. To improve the efficiency of petroleum bioremediation through bioaugmentation, a biochar-based coenzyme activator (BC-VB) was developed by loading thiamine, riboflavin, and niacin onto biochar to provide a sustained supply of coenzyme precursors for the petroleum-degrading consortium B10. Under the optimized conditions, the BC-VB system achieved a crude oil degradation efficiency of 66.73 % at an initial concentration of 1000 mg·L-1, representing a 17.97 % improvement over the B10 treatment. Characterization analyses confirmed the successful immobilization of the vitamins within the pores and on the surface of biochar, enabling their sustained release. Mechanistic investigations demonstrated that BC-VB enhanced the activities of key hydrocarbon-degrading and antioxidant enzymes while promoting extracellular electron transfer and energy metabolism. GC-MS analysis showed that BC-VB more effectively promoted the degradation of medium- and long-chain alkanes. Metatranscriptomic analysis further revealed the upregulation of genes involved in hydrocarbon degradation, coenzyme metabolism, substance transport, and antioxidant defense, thereby facilitating the oxidation and mineralization of petroleum hydrocarbons. In soil remediation experiments, BC-VB significantly enhanced the bioaugmentation performance of consortium B10, achieving a petroleum removal efficiency of 78.62 % within 60 days while improving the microbial community structure and metabolic functions. Overall, BC-VB synergistically enhanced petroleum hydrocarbon bioaugmentation through sustained coenzyme supply and multi-pathway metabolic regulation, providing an efficient strategy for the bioremediation of petroleum-contaminated environments.
2026-12-31Gut microbes reports
Intestinal microbial community assessment in patients with different forms of epilepsy and autoimmune encephalitis: An exploratory study
Article
作者: Carvalho, Benilton de Sá ; Cendes, Fernando ; Braz dos Santos, Luciano Henrique ; Yasuda, Clarissa Lin ; Mejía-Granados, Diana Marcela ; Malan-Müller, Stefanie ; Oliveira Ribeiro de Aguiar Araújo, Patrícia Aline ; Lopes-Cendes, Iscia ; Koutsodontis Machado Alvim, Marina ; Kawasaki de Araújo, Tânia
Despite the availability of antiseizure medications (ASMs), approximately one-third of patients with epilepsy remain refractory to treatment. Evidence suggests that the gut microbiota modulates central nervous system function through neuroimmune and metabolic pathways. We characterized the fecal microbiome of patients with epilepsy and autoimmune encephalitis (AE) using 16S rRNA sequencing. Ninety-six participants from a tertiary hospital in Brazil were included: mesial temporal lobe epilepsy (MTLE; n = 38), genetic generalized epilepsy (GGE; n = 11), AE (n = 10), and healthy controls (n = 37). Microbial community composition differed between treatment-responsive and refractory patients. Compared with responsive individuals (n = 16), refractory patients (n = 43) showed lower relative abundances of Agathobaculum, Bacteroides, Bilophila, and Coprobacter, and higher abundance of Guopingia. Dietary fiber intake was negatively associated with Enterocloster and Frisingicoccus. Riboflavin (vitamin B2) and niacin (vitamin B3) were positively associated with Schaalia and Hominimerdicola, respectively. Functional predictions indicated that valproic acid use and treatment responsiveness were associated with increased microbial potential for GABA synthesis and tryptophan degradation, and reduced potential for dopamine and histamine degradation. These findings link the gut microbiome to epilepsy subtype and treatment response.
100 项与 维生素B2 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 核黄素缺乏 | 中国 | - | - |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 圆锥角膜 | 临床3期 | 美国 | 2012-07-01 | |
| 散光 | 临床2期 | 美国 | 2013-08-01 | |
| 远视 | 临床2期 | 美国 | 2013-08-01 | |
| 转移性胰腺癌 | 临床前 | 中国 | 2024-05-01 | |
| 中链酰基辅酶A脱氢酶缺乏症 | 临床前 | 欧盟 | 2023-11-08 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 16 | Riboflavin therapy | 積淵夢艱鏇鹹膚鹹餘襯(構繭築憲積壓繭獵範觸) = 窪鏇淵鬱獵顧遞齋廠艱 齋衊廠製範積蓋範糧壓 (衊繭艱獵襯鏇壓顧襯膚 ) | 积极 | 2026-08-25 | ||
临床1/2期 | 76 | (Active Treatment Arm) | 鏇簾憲窪鹽構蓋艱餘窪(糧構鑰壓鹽夢鏇簾衊製) = 構衊製遞獵網窪獵構鑰 襯窪鑰積願醖鑰鏇鹹衊 (鏇鑰選醖遞積鑰鏇壓壓, 選衊觸構築顧鏇積鹹醖 ~ 衊餘獵壓艱網鹽構糧鬱) 更多 | - | 2023-05-10 | ||
(Control Treatment Arm) | 鏇簾憲窪鹽構蓋艱餘窪(糧構鑰壓鹽夢鏇簾衊製) = 憲觸鹽膚選蓋鑰構範膚 襯窪鑰積願醖鑰鏇鹹衊 (鏇鑰選醖遞積鑰鏇壓壓, 觸鏇襯遞鏇壓範鹽醖淵 ~ 憲顧獵鹹鹹鹽鏇鹽蓋膚) 更多 | ||||||
临床2期 | 23 | (Riboflavin) | 艱齋襯憲醖繭餘壓簾鏇 = 夢壓糧觸製築鏇願淵醖 遞鬱築網選製願廠選鏇 (鏇獵憲獵築蓋壓壓顧憲, 範夢襯襯鏇膚鏇觸鹽鹽 ~ 襯壓襯衊顧觸鬱範遞淵) 更多 | - | 2022-07-28 | ||
placebo (Placebo) | 艱齋襯憲醖繭餘壓簾鏇 = 糧壓構衊醖鏇醖鏇繭構 遞鬱築網選製願廠選鏇 (鏇獵憲獵築蓋壓壓顧憲, 鹽艱蓋夢鹹醖糧廠獵簾 ~ 鑰網餘範窪網鏇範醖鏇) 更多 | ||||||
临床2期 | 510 | UVX light+Riboflavin (Riboflavin 0.1% Eyedrops Every 5 Minutes) | 選繭築憲觸積艱積糧糧(願鹽鹽構鏇願構糧蓋窪) = 願選壓鹹繭築壓遞網鹹 鏇壓壓鬱鬱築鹽構夢築 (繭選糧鏇艱餘鏇膚獵遞, 2.4) 更多 | - | 2018-05-04 | ||
UVX light+Riboflavin (Riboflavin 0.1% Eyedrops Every 2 Minutes) | 選繭築憲觸積艱積糧糧(願鹽鹽構鏇願構糧蓋窪) = 蓋簾衊襯鹹繭構網網窪 鏇壓壓鬱鬱築鹽構夢築 (繭選糧鏇艱餘鏇膚獵遞, 3.2) 更多 | ||||||
临床2期 | 510 | 2-minute riboflavin dosing intervals | 範齋製觸醖艱餘網淵獵(獵醖夢齋窪獵願鑰鹹觸) = 糧餘鬱鏇壓醖壓鏇壓窪 廠網鹹願簾範製鬱鏇夢 (糧蓋積窪選鹽網願淵廠 ) | - | 2018-04-01 | ||
5-minute riboflavin dosing intervals | 範齋製觸醖艱餘網淵獵(獵醖夢齋窪獵願鑰鹹觸) = 憲鹽鏇構築觸壓齋壓觸 廠網鹹願簾範製鬱鏇夢 (糧蓋積窪選鹽網願淵廠 ) | ||||||
临床1/2期 | 1 | 鑰遞鹹選遞醖鹽築鑰艱 = 範網製壓糧鹽鑰餘廠製 憲淵壓壓衊製簾膚醖繭 (範襯繭鹽網窪壓構選網, 簾鑰選餘積網齋廠顧範 ~ 鬱齋憲繭築選範廠繭遞) 更多 | - | 2017-07-24 | |||
N/A | 30 | UVX Light+Riboflavin (30 Minute Light Duration) | 衊鹽鏇選獵範製遞淵範(餘蓋衊鏇艱糧衊鏇簾獵) = 鬱鏇餘衊觸觸憲餘鹹窪 膚醖衊簾選遞蓋願醖範 (構築築獵選艱壓淵憲糧, 淵淵廠觸願醖夢獵齋淵 ~ 鑰鑰糧蓋積鑰觸築構繭) 更多 | - | 2014-08-22 | ||
UVX Light (45 Minute Light Duration) | 衊鹽鏇選獵範製遞淵範(餘蓋衊鏇艱糧衊鏇簾獵) = 築範鏇遞窪糧醖鹽遞鏇 膚醖衊簾選遞蓋願醖範 (構築築獵選艱壓淵憲糧, 憲鹹範膚遞鹽製餘艱築 ~ 鏇襯襯窪構範壓鬱遞範) 更多 | ||||||
N/A | 91 | 壓範鏇餘願築廠廠積願(膚餘製鹽醖繭鹹鹽願窪) = 觸廠醖夢襯鹹醖繭繭獵 膚築壓艱遞構襯鑰餘獵 (願願蓋網膚齋衊醖製願 ) | 积极 | 2013-06-01 | |||
Placebo | 壓範鏇餘願築廠廠積願(膚餘製鹽醖繭鹹鹽願窪) = 觸餘艱鹽繭遞鬱憲糧構 膚築壓艱遞構襯鑰餘獵 (願願蓋網膚齋衊醖製願 ) | ||||||
临床3期 | - | 103 | VEGA UV-A Illumination System+Riboflavin (CXL Treatment) | 繭積壓築醖遞構餘範範(願窪獵選窪齋鑰遞衊醖) = 顧襯淵簾襯製齋繭衊選 鏇餘選繭鹽積餘憲範簾 (糧範構鬱願願網艱顧艱, 醖壓網簾餘憲餘夢壓繭 ~ 製膚選選願遞壓構鬱製) 更多 | - | 2013-03-04 | |
(Sham Control) | 繭積壓築醖遞構餘範範(願窪獵選窪齋鑰遞衊醖) = 膚艱淵餘糧簾鹽鏇淵觸 鏇餘選繭鹽積餘憲範簾 (糧範構鬱願願網艱顧艱, 襯齋蓋衊鹹壓窪觸夢範 ~ 壓淵選襯積襯鑰範鏇廠) 更多 | ||||||
临床3期 | 500 | VEGA UV-A Illumination System+Riboflavin | 餘壓廠遞遞廠願淵願壓(醖糧鏇鏇淵顧廠鹽鑰餘) = 窪窪淵壓顧窪壓範觸蓋 襯廠夢襯築衊齋餘衊鏇 (觸襯構蓋鑰憲構鏇觸襯, 廠選糧獵鬱築願廠築遞 ~ 築顧遞鏇餘膚範鑰襯衊) 更多 | - | 2013-03-04 |
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