Diabetes is a chronic disease that affects a large part of the United States population. The majority of patients with diabetes will experience gastrointestinal symptoms. One of the most troublesome gastrointestinal symptoms that diabetes can cause is diarrhea, otherwise known as "Diabetic Diarrhea." This occurs because diabetes does damage to nerves that control the gut and prevent it from functioning normally. Currently, there are only several medications used to treat the symptoms of Diabetic Diarrhea, but many of these medications have serious side effects or do not work well.
We are investigating the drug eluxadoline for the treatment of Diabetic Diarrhea. Eluxadoline is a gut-specific medication that is FDA approved to treat diarrhea related to irritable bowel syndrome (IBS-D). Our hypothesis is eluxadoline will safely and successfully reduce diarrhea symptoms (number of stools and less liquid stools) and improve the quality of life in patients with Diabetic Diarrhea when compared with placebo. Each patient with Diabetic Diarrhea who participates will take both eluxadoline and a placebo drug at separate times over a period of several months as part of a crossover study design. While on each medication, eluxadoline or placebo, the participants will keep a diary of symptoms and will be followed by the medical team through a combination of office visits and questionnaires. There will be five planned office visits and intermittent phone calls (questionnaires, surveys) over the 140-day study period. Participants will not be permitted to use any other anti-diarrhea medication during the study period and will continue on medication for management of their diabetes.

开始日期2022-07-01

申办/合作机构

Temple University Graduate School

[+1]

NCT04880876 / Enrolling by invitation临床3期

A Phase 3, Long-term Safety Study of Oral Eluxadoline Administered to Pediatric Participants With Irritable Bowel Syndrome With Diarrhea (IBS-D)

This study will assess the long-term safety of oral Eluxadoline administered to pediatric participants with IBS-D who have completed study intervention in the Phase 2 study 3030-202-002 or the Phase 3 study 3030-303-002.

开始日期2021-08-13

申办/合作机构

AbbVie, Inc.

NCT03489265 / Withdrawn临床2期IIT

Treatment of Diarrhea-Associated Fecal Incontinence With Eluxadoline

Accidental bowel leakage (fecal incontinence) increases in people who have diarrhea and sensations of urgency to have a bowel movement. Drugs such as loperamide (Imodium) that reduce diarrhea improve accidental bowel leakage, but loperamide has disadvantages: it is difficult to find a dose that does not cause constipation, and it does not reduce urge sensations. Eluxadoline is a new drug that is effective for reducing diarrhea, abdominal pain, and urgency in patients with irritable bowel syndrome, and it may be less likely than loperamide to cause severe constipation. Therefore, eluxadoline may help patients manage accidental bowel leakage caused by diarrhea. The chemical name for Viberzi® is eluxadoline.
The primary aims of this study are to find out if eluxadoline at a dose of 100 mg orally twice a day will reduce the average number of days the patient has accidental bowel leakage, and to see if the rate of accidental bowel leakage increases when the patient stops taking eluxadoline. Additional goals are to find out if eluxadoline decreases diarrhea and urge sensations.
This is a small (pilot) study to show whether eluxadoline is an effective way of treating accidental bowel leakage. If the study shows this, a larger study will be needed. There are three phases to this 12-week study: (1) A two-week run-in period to see if the patient meets the inclusion criteria. (2) Two months for treatment including one month on eluxadoline and one on placebo (sugar pills) twice a day. (3) A two-week follow-up to see what happens when you stop taking eluxadoline.
To participate in the study, patients should be aged 18 or older. Patients with inflammatory bowel disease, anal fissures, or congenital malformations will be excluded.
The primary outcome is the average number of days per week with any solid or liquid bowel accidents. Additional information includes: (1) Number of days per week the patient takes loperamide, (2) days per week with loose or watery stools, (3) days per week with moderate to strong urge sensations, and (4) questionnaires to measure the severity of accidental bowel leakage, quality of life, anxiety, and depression. There will be up to 38 patients in the study.

开始日期2019-04-01

申办/合作机构

The University of North Carolina at Chapel Hill

[+1]

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100 项与艾沙度林相关的转化医学

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100 项与艾沙度林相关的专利（医药）

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项与艾沙度林相关的文献（医药）

2024-06-01·Advances in therapy

Treatment-Free Interval: A Novel Approach to Assessing Real-World Treatment Effectiveness and Economic Impact Among Patients with Irritable Bowel Syndrome with Diarrhea

Article

作者: Guérin, Annie ; Dashputre, Ankur A ; Lacy, Brian E ; Heimanson, Zeev ; Bumpass, Brock ; Gagnon-Sanschagrin, Patrick ; Bungay, Rebecca ; Joseph, George ; Borroto, Danellys ; Bellefleur, Remi

INTRODUCTION:

Objective assessment of treatment effectiveness using real-world claims data is challenging. This study assessed treatment-free intervals (TFI) as a proxy for treatment effectiveness, and all-cause healthcare costs among adult patients with irritable bowel syndrome with diarrhea (IBS-D) treated with rifaximin or eluxadoline in the USA.

METHODS:

Adult patients (18-64 years) with IBS-D and ≥ 1 rifaximin or eluxadoline prescription were identified in the IQVIA PharMetrics^® Plus database (10/01/2015-12/31/2021) and classified into two mutually exclusive cohorts (i.e., rifaximin and eluxadoline). Index date was the date of rifaximin or eluxadoline initiation. Entropy-balanced baseline characteristics, TFI (periods of ≥ 30 consecutive days without IBS-D treatment), and healthcare costs were reported. Healthcare costs were compared between cohorts using mean cost differences.

RESULTS:

There were 7094 and 2161 patients in the rifaximin and eluxadoline cohorts, respectively. After balancing, baseline characteristics (mean age 44.1 years; female 72.4%) were similar between cohorts. A higher proportion of patients treated with rifaximin achieved a TFI of ≥ 30 days (76.2% vs. 66.7%), ≥ 60 days (67.0% vs. 47.0%), ≥ 90 days (61.0% vs. 38.7%), ≥ 180 days (51.7% vs. 31.0%), and ≥ 240 days (47.7% vs. 27.9%) compared to eluxadoline. Among patients with a TFI ≥ 30 days, mean TFI durations were 8.3 and 6.0 months for the rifaximin and eluxadoline cohorts. Mean all-cause healthcare costs were lower for rifaximin vs. eluxadoline ($18,316 vs. $23,437; p = 0.008), primarily driven by pharmacy costs ($7348 vs. $10,250; p < 0.001). In a simulated health plan of one million commercially insured lives, initiating 50% of patients on rifaximin instead of eluxadoline resulted in total cost savings of $2.1 million per year or $0.18 per-member-per-month.

CONCLUSIONS:

This real-world study suggests that TFI is a meaningful surrogate measure of treatment effectiveness in IBS-D. Patients treated with rifaximin had longer treatment-free periods and lower healthcare costs than patients treated with eluxadoline.

2024-05-03·Expert opinion on drug metabolism & toxicology

Pharmacokinetic considerations for drugs that treat diarrhea-predominant irritable bowel syndrome: what’s new?

Review

作者: Mozaffari, Shilan ; Nikfar, Shekoufeh ; Abdollahi, Mohammad

INTRODUCTION:

Irritable bowel syndrome (IBS), which presents a significant healthcare and socioeconomic burden, is one of the main issues in the field of therapy. Hence, it is imperative to tackle this matter by evaluating the safety and efficacy of the available treatments and determining the ideal approach for each patient.

AREAS COVERED:

We reviewed the pharmacokinetics and safety of pharmacologic interventions administered in diarrhea-predominant IBS (IBS-D) patients. PubMed, Google Scholar and the USFDA databases were searched up to November 2023 to include all updated information on eluxadoline, alosetron, and rifaximin.

EXPERT OPINION:

The most effective way to treat IBS-D is to focus on managing the most common symptoms. However, healthcare providers face a challenge when it comes to identifying the right treatment for each patient, and the root cause of this is the diversity of IBS-D population. Studies have shown that there are differences in how men and women metabolize drugs, which may lead to gender-specific adverse reactions. Women tend to have higher drug concentrations in their bloodstream and take longer to eliminate them. Therefore, healthcare providers may need to reduce the dosage for female patients. Integrating IBS care into sustainable development efforts can indirectly contribute to achieving SDGs and promote health and well-being for all.

2024-03-03·Expert opinion on investigational drugs

Drugs of the future for diarrhea-predominant irritable bowel syndrome: an overview of current investigational drugs

Review

作者: Mozaffari, Shilan ; Nikfar, Shekoufeh ; Abdollahi, Mohammad

INTRODUCTION:

Irritable bowel syndrome (IBS) has a significant impact on society and quality of life. Current treatments are ineffective, and new investigational drugs are necessary.

AREAS COVERED:

Numerous potential therapies are developing, targeting different areas such as cannabinoid signaling, opioid receptors, tachykinin (NK2) receptors, β3-adrenergic receptors, intestinal microbiota, inflammation, and 5HT receptors. Clinical trial evidence has shown that loperamide, eluxadoline, alosetron, ramosetron, bile acid sequestrants, and rifaximin can modulate GI alterations and benefit patients with IBS-D. Among the potential therapies, ibodutant, ibudilast, blautix, BOS-589, solabegron, vibegron, olorinab, ebastine, and ORP-101 have demonstrated possible effects but remain confirmed.

EXPERT OPINION:

Individuals with IBS-D require cost-effective treatment options that do not impede their productivity or that of their caregivers. This is necessary for consistent healthcare and improved quality of life. Therefore, we should focus on developing new, efficient, and affordable medications for IBS-D. The government, insurers, and society must recognize this need and collaborate to ensure its fulfillment.

项与艾沙度林相关的新闻（医药）

2024-06-04

·PRNewswire

Analysis Group Researchers Suggest a Novel Approach to Measuring Real-World Treatment Effectiveness for Irritable Bowel Syndrome with Diarrhea

BOSTON, June 4, 2024 /PRNewswire/ -- Researchers from Analysis Group, a global leader in health economics and outcomes research (HEOR), have coauthored a study detailing how treatment-free intervals (TFIs) can be an effective surrogate in retrospective data analyses for understanding therapy effectiveness for conditions that present multifaceted symptoms across widely divergent patient populations, such as irritable bowel syndrome with diarrhea (IBS-D). The study, published in the journal Advances in Therapy, is the first to use TFIs to assess real-world IBS-D therapy response, using two of the most commonly prescribed treatments in the US: rifaximin and eluxadoline. While the Food and Drug Administration (FDA) recommends using a five-item opinion-based questionnaire to measure patient-reported outcomes (PROs) that capture clinically important signs and symptoms to define treatment effects in clinical trials, it is challenging to apply this method to evaluate real-world outcomes in retrospective studies. The difficulty lies in the complex presentation of IBS-D, a common, chronic, relapsing, and potentially severe disorder of gut–brain interaction characterized by troublesome symptoms such as abdominal pain, diarrhea, fecal urgency, and bloating. To overcome these challenges, study investigators analyzed US commercial claims data for 9,255 IBS-D patients receiving one of the two treatments over the course of one year. The researchers focused on patients' TFI patterns – the length of time a patient remains off treatment after a course of therapy. Patient characteristics included age, sex, health plan type, region, and provider specialty, as of the index date. During baseline, medically relevant comorbidities (both gastrointestinal- and mental health–related), procedures (e.g., anesthesia, surgery, radiation services), and treatments were reported. Investigators specifically examined the duration of the index treatment, the number of prescription fills, and all-cause health care costs among adult patients with IBS-D treated with rifaximin or eluxadoline. The researchers concluded that TFIs may be a meaningful proxy for measuring treatment effectiveness in IBS-D. Using this method, they also found that patients treated with rifaximin had longer TFIs and lower health care costs than patients treated with eluxadoline. "The challenges of studying IBS-D are similar in many ways to those faced with oncology, where important treatment goals include medication-free periods associated with symptom control, especially when there is a treatment-related toxicity or financial burden associated with treatment changes or combination therapy," said study investigator Annie Guérin, a Managing Principal with Analysis Group. "Our approach to using TFIs was based on the proven strategies used in oncology, where patients value treatment-free periods because they are associated with improved health-related quality of life." The study, "Treatment-Free Interval: A Novel Approach to Assessing Real-World Treatment Effectiveness and Economic Impact Among Patients with Irritable Bowel Syndrome with Diarrhea," was published in April in Advances in Therapy. In addition to Ms. Guérin, investigators included Vice President Patrick S. Gagnon, Associate Rebecca Bungay, and Senior Research Professional Remi Bellefleur of Analysis Group; Brian E. Lacy of Mayo Clinic; Zeev Heimanson of Salix Pharmaceuticals; Brock Bumpass, Danellys Borroto, and Ankur A. Dashputre of Bausch Health; and George Joseph of BioNTech US. Funding was provided by Bausch Health. To learn more about Analysis Group's HEOR capabilities, visit About Analysis Group's HEOR, Epidemiology & Market Access Practice Founded in 1981, Analysis Group is one of the largest international economics consulting firms, with more than 1,200 professionals across 14 offices. Analysis Group's health care experts apply analytical expertise to health economics and outcomes research (HEOR), clinical research, market access and commercial strategy, and health care policy engagements, as well as drug safety-related engagements in epidemiology. Analysis Group's internal experts, together with our network of affiliated experts from academia, industry, and government, provide our clients with exceptional breadth and depth of expertise and end-to-end consulting services globally. Contact: Analysis Group Eric Seymour, +1 978 273 6049 [email protected] SOURCE Analysis Group

放射疗法临床结果临床研究

2023-06-07

·drugs

What Is Irritable Bowel Syndrome?

WEDNESDAY, June 7, 2023 -- People who suffer from irritable bowel syndrome (IBS) know it is a highly unpleasant chronic condition that can trigger abdominal pain, diarrhea and constipation. Here, experts will unravel the mysteries of IBS, exploring its causes, symptoms and treatments. And of course, don't forget about the role of diet. Experts will break down the best foods to eat and those to avoid for a happy gut. What is irritable bowel syndrome? According to the Mayo Clinic , irritable bowel syndrome is a common disorder targeting the gastrointestinal tract, encompassing the stomach and intestines. This chronic condition manifests through a range of distressing symptoms, including cramping, abdominal pain, bloating, excessive gas and the frustrating duo of diarrhea and constipation, which may occur individually or even simultaneously. Dealing with IBS requires a long-term management approach to address its persistent impact on daily life effectively. What causes IBS? The exact causes of irritable bowel syndrome remain uncertain, according to the National Institute of Diabetes and Digestive and Kidney Issues (NIDDK). However, experts believe that a combination of factors contributes to its development. IBS is considered a functional gastrointestinal (GI) disorder involving the intricate interaction between the brain and the gut. Here are some potential causes and factors that may play a role in IBS: Problems with brain-gut interaction. Brain and gut communication can impact the body's functioning, triggering IBS symptoms. This can include abnormal food movement through the digestive tract, resulting in changes in bowel movements, and experiencing pain even with average amounts of gas or stool in the gut. Stressful or difficult early-life events. Traumatic experiences during childhood, such as physical or sexual abuse, have been associated with an increased risk of developing IBS. Mental disorders. Conditions like depression, anxiety and somatic symptom disorder are more common among individuals with IBS and may contribute to its onset. Bacterial infections. Infections of the digestive tract caused by certain bacteria have been linked to developing IBS. Small intestinal bacterial overgrowth. In terms of increased numbers or changes in the bacterial type, an overgrowth of bacteria in the small intestine has been associated with IBS. Food intolerances or sensitivities. Some individuals with IBS may experience digestive symptoms triggered by specific foods, indicating intolerances or sensitivities to certain dietary components. The causes of IBS can vary among individuals, highlighting this condition's complexity. IBS symptoms In a recent video with Dr. Jennifer Webster , a pediatric gastroenterologist with Children’s Hospital of Philadelphia, she indicates that “the tricky thing about IBS is that there is no specific test that we can use to say 100% you have this . We do lots of testing to rule out other diseases. Similar to migraines, there isn’t a test, but we know that the pain is real and the symptoms are real.” While some studies suggest potential differences in the prevalence and severity of IBS symptoms between men and women, it is worth noting that the core symptoms are relatively similar. Here are some typical symptoms of IBS in men and women, according to Johns Hopkins Medicine : Abdominal pain or cramping. This is one of the hallmark symptoms of IBS. The pain is often described as a lower abdominal discomfort or cramping sensation that may vary in intensity. Bloating and distention. Many individuals with IBS experience bloating, a feeling of increased pressure or fullness in the abdomen. This can be accompanied by visible abdominal distention or swelling. Altered bowel habits. IBS can lead to changes in bowel movements. These changes can include diarrhea, characterized by loose or watery stools, and constipation, characterized by infrequent or difficult bowel movements. Some individuals may alternate between episodes of diarrhea and constipation. Excessive gas. Many people with IBS may notice increased gas production, leading to bloating, belching or flatulence. Urgency or an incomplete bowel movement. Some individuals with IBS may experience a sense of urgency to have a bowel movement or feel as though they haven't fully emptied their bowels after a bowel movement. Mucus in the stool. In some cases, people with IBS may notice the presence of mucus in their stool. Can a specific diet for IBS help with symptoms? When managing symptoms of IBS, changing your diet can play a significant role. Here are some common dietary recommendations for individuals with IBS: The NIDDK suggests the following foods to eat with irritable bowel syndrome : Increase fiber intake. Focus on incorporating sources of soluble fiber, such as oats, bananas, carrots and psyllium husk, into your diet. Avoid gluten. Avoiding gluten-containing grains like wheat, barley and rye may be beneficial for individuals with gluten sensitivity or celiac disease. Opt for gluten-free alternatives like quinoa, rice and gluten-free oats. Follow a low-FODMAP diet. Following a special diet known as the low- FODMAP diet may provide relief for some individuals with IBS. This diet for IBS involves temporarily restricting certain high-FODMAP foods, such as onions, garlic, wheat and fruits such as apples, cherries, nectarines, pears and watermelon, or juice containing any of these fruits, then gradually reintroducing them to identify specific triggers. IBS treatments The treatment of IBS aims to alleviate symptoms, allowing individuals to live as symptom-free as possible. Depending on your symptoms, your health care provider may recommend different approaches on how to treat your IBS, including medication and IBS self-care strategies. Here are some commonly prescribed irritable bowel syndrome medications as indicated by the Mayo Clinic: Alosetron (Lotronex). This medication is designed to relax the colon and slow down the movement of waste through the lower bowel. It is primarily prescribed for severe cases of IBS in women and is not approved for use in men. Eluxadoline (Viberzi). Eluxadoline is a medication that aids in reducing diarrhea by decreasing fluid secretion and muscle contractions in the intestine while simultaneously enhancing muscle tone in the rectum. Rifaximin (Xifaxan). This antibiotic decreases bacterial overgrowth in the gut and relieves diarrhea symptoms. Lubiprostone (Amitiza). Lubiprostone increases fluid secretion in the small intestine, aiding in the passage of stool. It is approved for women with IBS with constipation. Linaclotide (Linzess). Linaclotide also increases fluid secretion in the small intestine to facilitate bowel movements. Living with IBS Living with IBS can be challenging, but there are ways to manage its symptoms and improve your quality of life. Working closely with health care professionals allows you to explore dietary modifications, medication options and self-care strategies tailored to your needs. Posted June 2023

上市批准

2022-06-24

·PRNewswire

Irritable Bowel Syndrome Treatment Market to Surpass US$ 3,902.9 Million by 2030 - Coherent Market Insights

SEATTLE, June 24, 2022 /PRNewswire/ -- According to Coherent Market Insights, the global irritable bowel syndrome treatment market is estimated to be valued at US$ 1,444.7 million in 2022 and is expected to exhibit a CAGR of 13.2% during the forecast period (2022-2030). Key Trends and Analysis of the Global Irritable Bowel Syndrome Treatment Market: Major players operating in the market are focusing on conducting workshops to create awareness regarding irritable bowel syndrome, which is expected to drive the market growth over the forecast period. For instance, in May 2018, Allergan plc, a subsidiary of AbbVie Inc., a biopharmaceutical company, and Ironwood Pharmaceuticals, Inc., a healthcare company, announced the launch of the AboutYourGut.com website. The aim of this launch was to help educate sufferers impacted by irritable bowel syndrome with diarrhea (IBS-D), irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC), including providing information on condition management. Request Sample Copy of this Report @ Key Market Takeaways: The global irritable bowel syndrome treatment market is expected to exhibit a CAGR of 13.2% during the forecast period due to the increasing adoption of inorganic strategies such as agreements by the key players in the market. For instance, in May 2021, Ironwood Pharmaceuticals, Inc., a healthcare company, and its partner AbbVie Inc., a biopharmaceutical company, reached an agreement with Teva Pharmaceuticals USA, Inc., a multinational pharmaceutical company. As per the terms of this agreement, Teva Pharmaceuticals USA, Inc., would be granted a license to market its 72 mcg generic version of LINZESS, the first prescribed brand in the U.S. for the treatment of adult patients with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC), in the U.S. beginning March 31, 2029 (subject to U.S. FDA approval), unless certain limited circumstances, customary for settlement agreements of this nature occur. Among medical conditions, the IBS-constipation segment is expected to dominate the segment growth over the forecast period, owing to the increased research and development activities by the key players in the market. For instance, in May 2021, 4D pharma plc., a pharmaceutical company leading the development of Live Biotherapeutic products (LBPs), a novel class of drug derived from the microbiome, announced positive data from its completed Phase II trial of LBP Blautix, a single strain live biotherapeutic product (LBP), in subjects with irritable bowel syndrome with constipation (IBS-C) or with diarrhea (IBS-D). On the basis of drug type, the Linaclotide segment is expected to dominate the segment growth over the forecast period, owing to the increasing approvals for linaclotide. For instance, in August 2021, Ironwood Pharmaceuticals, Inc., a healthcare company, announced that the U.S. Food and Drug Administration (FDA) approved a revised label for LINZESS (linaclotide) based on clinical safety data that had been generated in pediatric studies. Key players operating in the global irritable bowel syndrome treatment market include Abbott, Synergy Pharma, Mallinckrodt, Bausch Health Companies Inc., Ardelyx, Astellas Pharma Inc., Novartis AG, GSK plc., Ironwood Pharmaceuticals, Inc., and Takeda Pharmaceutical Company Limited. Request for Customization @ Detailed Segmentation: Global Irritable Bowel Syndrome Treatment Market, By Drug Type: Lubiprostone Linaclotide Eluxadoline Rifaximin Alosetron Other Global Irritable Bowel Syndrome Treatment Market, By Medical Condition: IBS-constipation IBS-diarrhea Global Irritable Bowel Syndrome Treatment Market, By Distribution Channel: Hospital Pharmacies Retail Pharmacies Online Pharmacies Global Irritable Bowel Syndrome Treatment Market, By Region: North America By Country: U.S. Canada Europe By Country: U.K. Germany Italy France Spain Russia Rest of Europe Asia Pacific By Country: China India Japan ASEAN Australia South Korea Rest of Asia Pacific Latin America By Country: Brazil Mexico Argentina Rest of Latin America Middle East & Africa By Country: GCC Countries Israel South Africa Rest of Middle East & Africa Buy this Complete Report Now @ Find related trending report below: Short Bowel Syndrome Market — Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2022-2028 About Us: Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions. We are headquartered in India, having sales office at global financial capital in the U.S. and sales consultants in United Kingdom and Japan. Our client base includes players from across various business verticals in over 57 countries worldwide. We create value for clients through our highly reliable and accurate reports. We are also committed in playing a leading role in offering insights in various sectors post-COVID-19 and continue to deliver measurable, sustainable results for our clients. Contact Us: Mr. Shah Senior Client Partner – Business Development Coherent Market Insights Phone: US: +1-206-701-6702 UK: +44-020-8133-4027 Japan: +81-050-5539-1737 India: +91-848-285-0837 Email: [email protected] Website: Follow Us: LinkedIn | Twitter Logo: SOURCE Coherent Market Insights

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100 项与艾沙度林相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10403	艾沙度林	A07DA06	DB09272

研发状态

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10 条最早获批的记录,

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适应症	国家/地区	公司	日期
腹泻型肠易激综合征	欧盟	Allergan Pharmaceuticals International Ltd.	2016-09-19
腹泻型肠易激综合征	冰岛	Allergan Pharmaceuticals International Ltd.	2016-09-19
腹泻型肠易激综合征	列支敦士登	Allergan Pharmaceuticals International Ltd.	2016-09-19
腹泻型肠易激综合征	挪威	Allergan Pharmaceuticals International Ltd.	2016-09-19
肠易激综合征	美国	AbbVie, Inc.	2015-05-27

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适应症	最高研发状态	国家/地区	公司	日期
糖尿病	临床3期	美国	Allergan Ltd. (Ireland)	2022-07-01
腹泻	临床3期	美国	Allergan Ltd. (Ireland)	2022-07-01
大便失禁	临床2期	-	Allergan Ltd. (Ireland)	2019-04-01
肠瘘	临床2期	-	Allergan Ltd. (Ireland)	2019-04-01
急迫性尿失禁	临床2期	-	Allergan Ltd. (Ireland)	2019-04-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03441581 (3030-401-002, CTgov)	临床4期	腹泻型肠易激综合征 \| 胆汁酸吸收不良（BAM）	24	Eluxadoline (Eluxadoline 100 mg With BAM)	製膚廠簾壓鑰製艱製範(獵鹽夢繭範築膚繭鑰鹽) = 觸夢遞衊衊網獵選窪製顧衊膚遞齋範壓襯範遞 (膚廠鹹繭鏇選製鑰鏇憲, 遞憲遞遞構淵觸鑰憲廠 ~ 鏇構築製獵淵範餘醖築) 更多	-	2021-05-19
				Eluxadoline (Eluxadoline 100 mg Without BAM)	製膚廠簾壓鑰製艱製範(獵鹽夢繭範築膚繭鑰鹽) = 鑰選鹽鑰積鹹衊遞簾糧顧衊膚遞齋範壓襯範遞 (膚廠鹹繭鏇選製鑰鏇憲, 鏇顧簾淵顧蓋鹽窪鹽糧 ~ 構製築鑰襯願網艱淵範) 更多
NCT01130272 (CTgov)	临床2期	腹泻 \| 肠易激综合征	807	Eluxadoline (Eluxadoline 5 mg)	壓艱鹽夢鏇鬱鏇齋願簾(觸觸壓廠選鑰鏇構淵糧) = 範製醖糧憲願鑰鹹製夢願遞繭顧積膚壓憲構繭 (壓壓襯願蓋願鏇蓋廠遞, 積鑰製鹹繭膚鹹衊齋觸 ~ 鏇選窪蓋糧構淵鬱遞鏇) 更多	-	2019-10-22
				Eluxadoline (Eluxadoline 25 mg)	壓艱鹽夢鏇鬱鏇齋願簾(觸觸壓廠選鑰鏇構淵糧) = 構願顧築餘鹽壓廠繭蓋願遞繭顧積膚壓憲構繭 (壓壓襯願蓋願鏇蓋廠遞, 網鑰齋鬱構襯艱衊網鏇 ~ 糧遞襯廠鏇膚鏇範構窪) 更多
NCT02959983 (RELIEF, Pubmed \| Am J Gastroenterol) 人工标引	临床4期	腹泻 \| 肠易激综合征	346	Eluxadoline	獵製鹹鹹窪觸鏇糧憲獵(鏇廠積鬱餘範蓋膚餘艱) = 願襯壓壓蓋獵獵繭鹽糧鹽夢鑰襯鹽構網壓艱醖 (鹽淵餘觸齋廠繭觸窪鹹 ) 更多	积极	2019-09-01
				Placebo	獵製鹹鹹窪觸鏇糧憲獵(鏇廠積鬱餘範蓋膚餘艱) = 夢艱壓觸觸觸衊齋淵糧鹽夢鑰襯鹽構網壓艱醖 (鹽淵餘觸齋廠繭觸窪鹹 ) 更多
NCT02959983 (RELIEF, CTgov)	临床4期	腹泻型肠易激综合征 \| 腹泻	346	Eluxadoline (Eluxadoline)	選選醖襯積簾糧糧獵網(憲獵獵鏇夢糧衊選窪夢) = 夢鬱鹽繭繭觸壓積構製顧遞選積鑰鏇窪獵襯蓋 (憲衊壓繭淵鏇淵鏇顧顧, 製襯製簾積網膚鏇獵鹹 ~ 夢鬱鬱鏇鏇積範廠製範) 更多	-	2019-02-15
				Placebo (Placebo)	選選醖襯積簾糧糧獵網(憲獵獵鏇夢糧衊選窪夢) = 壓鏇餘範淵夢淵顧願遞顧遞選積鑰鏇窪獵襯蓋 (憲衊壓繭淵鏇淵鏇顧顧, 膚獵觸製蓋獵範淵製糧 ~ 積憲製淵鹽餘範鹹憲醖) 更多
NCT01553591 (CTgov)	临床3期	腹泻型肠易激综合征	1,282	Eluxadoline (Eluxadoline 75 mg)	鬱願糧淵遞蓋構艱夢製(艱衊繭鹹鬱簾膚廠糧鏇) = 願獵窪膚齋鏇淵願鹽蓋鹽遞淵醖繭觸選廠積襯 (顧壓鹽鬱衊艱糧鬱鏇夢, 糧憲鹽鬱鏇範襯範範鏇 ~ 繭鏇獵繭選簾餘選齋製) 更多	-	2018-09-04
				Eluxadoline (Eluxadoline 100 mg)	鬱願糧淵遞蓋構艱夢製(艱衊繭鹹鬱簾膚廠糧鏇) = 廠積顧獵艱齋簾獵範觸鹽遞淵醖繭觸選廠積襯 (顧壓鹽鬱衊艱糧鬱鏇夢, 襯淵構製積蓋網簾積廠 ~ 膚壓鹽願窪糧淵獵憲鬱) 更多
NCT01553747 (CTgov)	临床3期	腹泻型肠易激综合征	1,146	Eluxadoline (Eluxadoline 75 mg)	願築簾齋齋繭衊淵簾鬱(鑰廠齋窪糧鬱壓醖網襯) = 淵顧齋憲願餘網願窪糧範壓鹽糧築廠憲網獵鏇 (齋鏇餘鹹鬱襯壓顧鬱艱, 築築襯願範衊範壓壓膚 ~ 憲醖鑰選鑰淵獵壓壓襯) 更多	-	2018-07-30
				Eluxadoline (Eluxadoline 100 mg)	願築簾齋齋繭衊淵簾鬱(鑰廠齋窪糧鬱壓醖網襯) = 網範淵鏇鏇製鏇製憲壓範壓鹽糧築廠憲網獵鏇 (齋鏇餘鹹鬱襯壓顧鬱艱, 鑰網鹹構製選築鏇顧醖 ~ 蓋選選願鬱餘範鹹觸獵) 更多
UEGW	N/A	腹泻型肠易激综合征	-	Eluxadoline 75 mg	鹹繭餘壓積廠顧遞廠窪(襯鹹艱繭廠積艱衊選範) = 糧製築鏇築衊憲構鹹繭獵糧範廠蓋獵鬱製願蓋 (蓋選築積膚壓淵繭蓋襯 )	-	2017-10-01
				Eluxadoline 100 mg	鹹繭餘壓積廠顧遞廠窪(襯鹹艱繭廠積艱衊選範) = 簾廠鹹獵鹹餘簾糧窪廠獵糧範廠蓋獵鬱製願蓋 (蓋選築積膚壓淵繭蓋襯 )
UEGW	N/A	肠易激综合征	-	Eluxadoline 100 mg BID	憲壓網製壓廠願鬱衊構(齋簾廠遞夢鏇糧顧簾鹽) = 遞醖範淵壓選壓壓醖鑰膚餘衊鑰鹽糧膚衊衊憲 (選淵獵簾製鑰觸壓獵淵 )	-	2017-10-01
				Eluxadoline 75 mg BID	憲壓網製壓廠願鬱衊構(齋簾廠遞夢鏇糧顧簾鹽) = 淵鏇鬱夢蓋憲積醖艱製膚餘衊鑰鹽糧膚衊衊憲 (選淵獵簾製鑰觸壓獵淵 )
UEGW2016	N/A	腹泻型肠易激综合征	-	Eluxadoline 75 mg	獵製淵襯憲繭夢鹹淵選(鹽鹽觸願遞簾襯醖艱鬱) = 繭膚餘醖襯選簾餘餘獵獵觸鑰衊網鹹壓糧選壓 (齋醖遞範選顧築衊簾鏇 ) 更多	-	2016-10-01
				Eluxadoline 100 mg	獵製淵襯憲繭夢鹹淵選(鹽鹽觸願遞簾襯醖艱鬱) = 積網膚選願遞鬱構獵獵獵觸鑰衊網鹹壓糧選壓 (齋醖遞範選顧築衊簾鏇 ) 更多
IBS-3001 and IBS-3002 (Pubmed \| N Engl J Med)	临床3期	腹泻型肠易激综合征	2,427	Eluxadoline 75 mg	簾憲觸齋鬱窪夢壓夢憲(觸餘簾夢鹽窪觸淵獵淵) = 窪衊廠積齋遞糧鹽觸餘憲衊觸鹹繭積顧願鹽憲 (糧鏇獵餘餘膚壓憲齋衊 ) 更多	-	2016-01-21
				Eluxadoline 100 mg	簾憲觸齋鬱窪夢壓夢憲(觸餘簾夢鹽窪觸淵獵淵) = 鹹鹽窪鑰艱糧壓網願網憲衊觸鹹繭積顧願鹽憲 (糧鏇獵餘餘膚壓憲齋衊 ) 更多