氨苄西林/氯唑西林钠(Ampicillin/Cloxacillin Sodium) - 药物靶点：PBPs_在研适应症：心内膜炎，脑膜炎，呼吸道感染_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Viccillin、Viccillin-S、ビクシリン

靶点

PBPs

作用机制

PBPs抑制剂(细菌青霉素结合蛋白家族抑制剂)

治疗领域

感染神经系统疾病心血管疾病+ [3]

在研适应症

心内膜炎脑膜炎呼吸道感染+ [5]

非在研适应症-

原研机构

Meiji Seika Pharma Co., Ltd.

在研机构

Bright Future Pharmaceuticals Factory

Meiji Seika Pharma Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1970-08-01),

肺脓肿肺炎

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C19H20ClN3NaO6S

InChIKeyKNNWTOJBVOKDPC-VICXVTCVSA-N

CAS号7081-44-9

查看全部结构式(2)

关联

100 项与氨苄西林/氯唑西林钠相关的临床结果

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100 项与氨苄西林/氯唑西林钠相关的转化医学

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100 项与氨苄西林/氯唑西林钠相关的专利（医药）

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5

项与氨苄西林/氯唑西林钠相关的文献（医药）

1996-07-01·Kyobu geka. The Japanese journal of thoracic surgery

[A case report of an infective endocarditis caused by methicillin-resistant Staphylococcus aureus with successful mitral valve replacement].

Article

作者: Wakita, N ; Kawahira, T ; Nohara, H ; Shida, T

We report a case of successful mitral valve replacement performed on the patient who is an infective endocarditis due to MRSA. She was 27-year-old female and treated by antibiotics medication because of remittent fever two years ago. On August 1995, cerebral infarction occurred and she was pointed out endocarditis. After high fever continued, blood cultures demonstrated MRSA. Furthermore, echocardiography showed vegetation on posterior mitral valve leaflet and moderate mitral regurgitation so, mitral valve replacement with a S.J.M. 25 mm performed to control MRSA sepsis condition. During operation, we used VCM 2 g into the extracorporeal circulation and after operation 0.5 g intravenously every 6 hours. Two weeks later we changed antibiotics to FOM, Viccillin and ABK according to the result of minimum inhibitory concentration (MIC) obtained through blood culture. The patient was discharged on the 44 th postoperative day because of her uneventful postoperative course.

1978-01-01·The Japanese journal of antibiotics

[Therapeutic results of respiratory tract infections treated by intravenous drip with Viccillin S, a combined preparation of synthetic penicillins (author's transl)].

Article

作者: Nasu, M ; Hara, K ; Ishizaki, A ; Nakatomi, M ; Tsutsumi, T ; Izumikawa, K I

1971-06-01·The Japanese journal of antibiotics

[Clinical experience with drip infusion of ampicillin-cloxacillin combination (Viccillin S, "Meiji")].

Article

作者: Suganuma, Y ; Tateno, H ; Hirata, K ; Kikuchi, K

100 项与氨苄西林/氯唑西林钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	J01CA51	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心内膜炎	中国	Bright Future Pharmaceuticals Factory	2012-08-16
脑膜炎	中国	Bright Future Pharmaceuticals Factory	2012-08-16
呼吸道感染	中国	Bright Future Pharmaceuticals Factory	2012-08-16
脓毒症	中国	Bright Future Pharmaceuticals Factory	2012-08-16
软组织感染	中国	Bright Future Pharmaceuticals Factory	2012-08-16
泌尿道感染	中国	Bright Future Pharmaceuticals Factory	2012-08-16
肺脓肿	日本	Meiji Seika Pharma Co., Ltd.	1970-08-01
肺炎	日本	Meiji Seika Pharma Co., Ltd.	1970-08-01