预约演示
更新于：2026-05-23
GQ-1001
更新于：2026-05-23
概要
基本信息
药物类型 ADC |
别名 GQ 1001、GQ1001 |
作用方式 拮抗剂、抑制剂 |
作用机制 HER2拮抗剂(受体蛋白酪氨酸激酶 erbB-2拮抗剂)、微管蛋白抑制剂、ADCC(抗体依赖的细胞毒作用) |
非在研适应症 |
原研机构 |
在研机构 |
非在研机构- |
最高研发阶段临床1期 |
首次获批日期- |
最高研发阶段(中国)临床1期 |
特殊审评- |
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结构/序列
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Sequence Code 18481L
Sequence Code 44772H
关联
2
项与 GQ-1001 相关的临床试验NCT05575804
Phase Ib/II Study of GQ1001 and Pyrotinib in HER2 Positive Metastatic Breast Cancer Patients Who Had Failed Previous Anti-HER2 Treatment（GRACE）
NCT04450732
A Phase 1, First-In-Human, Multicenter, Open-Label, Study of GQ1001, a HER2 Targeted Antibody-Drug Conjugate, Administered Intravenously, in Adult Patients With HER2-Positive Advanced Solid Tumors
100 项与 GQ-1001 相关的临床结果
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100 项与 GQ-1001 相关的转化医学
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100 项与 GQ-1001 相关的专利（医药）
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269
项与 GQ-1001 相关的文献（医药）2025-08-01BIOMEDICINE & PHARMACOTHERAPY
Advanced breast cancer immunotherapy: Surface modification of NK cells for embedding antibody-drug conjugates
Article
作者: Kim, Yeongbeom ; Kim, Hongbin ; Park, Jeong-Ann ; Kim, Yihyeon ; Lim, Su Yeon ; Han, Seungmin ; Won, Young-Wook ; Yun, Jina ; Lim, Kwang Suk ; Yong, Seok-Beom
The combination of antibody-drug conjugates (ADCs) and immunotherapy has emerged as a promising strategy for cancer treatment. However, effective integration of chemotherapy and immunotherapy remains a challenge. Here, we introduce a universal surface-engineered NK (USE-NK) platform, which rapidly modifies immune cells into a targeted chemoimmunotherapy system by enabling the spontaneous incorporation of antibodies or ADCs. This platform utilizes a recombinant fusion protein (C3) derived from Protein G and a polymeric lipid-based conjugation strategy to stably attach therapeutic antibodies to NK cell surfaces without genetic modifications, preserving their native functionality. This approach enhances tumor targeting, minimizes off-target toxicity, and maintains NK cell cytotoxicity. Both in vitro and in vivo studies demonstrated that USE-NK conjugated with trastuzumab (TZ) or trastuzumab-emtansine (T-DM1) exhibited superior HER2-positive cancer cell recognition and cytotoxicity compared to NK cells treated with each agent separately. This enhancement was driven by the combined effects of 1) targeted delivery of potent chemotherapeutic agents with minimizing off-target toxicity, 2) enhanced mobilization of USE-NK toward tumor tissue, and 3) the cytotoxic activity of USE-NK against cancer cells. This rapid, non-invasive, and reversible engineering method provides a flexible approach to chemoimmunotherapy. Additionally, it extends beyond NK cells to other immune cell therapies, including CAR-T and CAR-NK cells. By leveraging the antibody-binding ability of C3, this platform enables multi-antigen targeting to address tumor heterogeneity. The scalability and adaptability of USE-NK position it as a promising candidate for personalized and off-the-shelf cancer immunotherapies.
2025-07-01ACS Nano
Membrane Fusion Drives Facile Uptake of Cell Membrane-Coated Nanocarriers
Article
作者: Alp, Yasin ; Qiu, Jingyi ; Thayumanavan, S. ; Medeiros, Jewel ; Gong, Shuai ; Agnello, Emily
Endocytosis has been the bane of the intracellular delivery efficiency of nanoscale systems. A class of delivery systems, viz., cell membrane-coated nanoparticles (CMNPs), show efficacious and even cell-selective uptake. We were interested in investigating the mechanism of interaction between cells and CMNPs, especially in the context of endocytic uptake and endosomal escape. We find that CMNPs are mainly taken up through a membrane-fusion-driven uptake pathway, bypassing endosomal entrapment and directly delivering therapeutic cargo to the cytoplasm. This fusion mechanism results in a significant enhancement in the intracellular delivery efficiency of both hydrophobic small molecules and nucleic acids as the cargo. The cargo-agnostic increase in delivery efficacy suggests a broad impact of this delivery system in diverse therapeutic areas.
2025-07-01Molecular Oncology
Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients
Article
作者: Jirka Grosse ; Peter Ugocsai ; Wolfgang Dietmaier ; Michael Althammer ; Florian Weber ; Florian Lüke ; Tobias Pukrop ; Kamran Honarnejad ; Daniel Heudobler ; Nataša Stojanović Gužvić ; Anke Schlenska-Lange ; Katja Evert ; Christoph A. Klein ; Stephan Seitz ; Martin Hoffmann ; Thomas Schamberger ; Kathrin Weidele ; Christian Werno ; Xin Lu ; Jens Warfsmann ; Steffi Treitschke ; Ulrich Kaiser ; Bernhard Polzer ; Felix Keil ; Roman Mayr ; Christian Schulz ; Giancarlo Feliciello ; Catherine Botteron ; Dirk Hellwig ; Adithi Ravikumar Varadarajan ; Silvia Materna–Reichelt ; Andrea Coluccio
While cell‐free liquid biopsy (cfLB) approaches provide simple and inexpensive disease monitoring, cell‐based liquid biopsy (cLB) may enable additional molecular genetic assessment of systemic disease heterogeneity and preclinical model development. We investigated 71 blood samples of 62 patients with various advanced cancer types and subjected enriched circulating tumor cells (CTCs) to organoid culture conditions. CTC‐derived tumoroid models were characterized by DNA/RNA sequencing and immunohistochemistry, as well as functional drug testing. Results were linked to molecular features of primary tumors, metastases, and CTCs; CTC enumeration was linked to disease progression. Of 52 samples with positive CTC counts (≥1) from eight different cancer types, only CTCs from two salivary gland cancer (SGC) patients formed tumoroid cultures (P = 0.0005). Longitudinal CTC enumeration of one SGC patient closely reflected disease progression during treatment and revealed metastatic relapse earlier than clinical imaging. Multiomics analysis and functional in vitro drug testing identified potential resistance mechanisms and drug vulnerabilities. We conclude that cLB might add a functional dimension (to the genetic approaches) in the personalized management of rare, difficult‐to‐treat cancers such as SGC.
24
项与 GQ-1001 相关的新闻（医药）2026-02-09
临床申请siRNA抗体药物偶联物临床1期免疫疗法
2026-02-08
·信狐药迅
2026-02-02
·谈医说药
疫苗信使RNA申请上市临床1期核酸药物
100 项与 GQ-1001 相关的药物交易
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| HER2阳性转移性乳腺癌 | 临床2期 | 中国 | 2022-10-01 | |
| 晚期恶性实体瘤 | 临床1期 | 美国 | 2020-07-07 | |
| 晚期恶性实体瘤 | 临床1期 | 中国 | 2020-07-07 | |
| 晚期恶性实体瘤 | 临床1期 | 澳大利亚 | 2020-07-07 | |
| HER2阳性胆道肿瘤 | 临床1期 | 美国 | 2020-07-07 | |
| HER2阳性胆道肿瘤 | 临床1期 | 中国 | 2020-07-07 | |
| HER2阳性胆道肿瘤 | 临床1期 | 澳大利亚 | 2020-07-07 | |
| HER2阳性乳腺癌 | 临床1期 | 美国 | 2020-07-07 | |
| HER2阳性乳腺癌 | 临床1期 | 澳大利亚 | 2020-07-07 | |
| HER2阳性唾液腺癌 | 临床1期 | 美国 | 2020-07-07 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1期 | HER2阳性实体瘤 HER2 positive | 32 | 獵選憲鬱糧構淵構遞簾(選衊範蓋鑰醖願壓艱壓) = 4/32, 12.5% 餘遞構網鑰壓顧廠襯醖 (顧齋積製襯膚廠鏇遞繭 ) | 积极 | 2025-01-09 | ||
临床1期 | 15 | 遞餘鹹窪鏇願淵願齋築(範夢鏇觸餘衊艱餘夢鑰) = 艱遞構襯築醖壓艱積構 遞製遞廠獵壓選積醖願 (簾艱艱築製鹽鹽鑰顧顧 ) | 积极 | 2024-11-26 | |||
遞餘鹹窪鏇願淵願齋築(範夢鏇觸餘衊艱餘夢鑰) = 淵廠廠觸遞築製鬱顧鹽 遞製遞廠獵壓選積醖願 (簾艱艱築製鹽鹽鑰顧顧 ) | |||||||
临床1期 | 15 | 夢願鑰鹽夢艱鬱獵鹹鹽(窪顧憲範簾願範積鹽鹽) = 獵獵餘餘簾鹽範廠獵糧 積廠夢選艱鏇築淵夢鹽 (鑰願簾簾願壓鹹構遞夢 ) 更多 | 积极 | 2023-04-14 | |||
窪襯顧蓋蓋齋鬱糧蓋壓(淵憲襯憲壓選窪糧觸鹽) = 蓋鏇鬱夢顧觸積醖廠獵 襯襯壓鬱齋鹹構製廠鏇 (繭醖齋選衊襯繭顧鑰願 ) 更多 |
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