药物类型 单克隆抗体 |
别名 Anti-HERV-W humanized monoclonal antibodies(GeNeuro)、Immunoglobulin G4, anti-(multiple sclerosis-associated retrovirus viral envelope protein) (human-mus musculus monoclonal gnbac1 heavy chain), disulfide with human-mus musculus monoclonal gnbac1 kappa-chain, dimer、Temelimab + [5] |
靶点 |
作用机制 ERV env inhibitors(ERV包膜基因抑制剂) |
原研机构 |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
---|---|---|---|---|
新冠肺炎后遗症 | 临床2期 | 意大利 | 2022-08-29 | |
新冠肺炎后遗症 | 临床2期 | 西班牙 | 2022-08-29 | |
新冠肺炎后遗症 | 临床2期 | 瑞士 | 2022-08-29 | |
神经精神综合征 | 临床2期 | 瑞士 | 2022-01-30 | |
复发性多发性硬化 | 临床2期 | 瑞典 | 2020-06-17 | |
多发性硬化症 | 临床1期 | - | 2011-07-01 |
临床2期 | 复发性多发性硬化 serum neurofilament light chain (NfL) | glial fibrillary acidic protein (GFAP) | 41 | 衊鬱廠積鬱簾醖餘網獵(醖憲醖獵繭淵膚鏇願築) = 願簾壓餘膚範築齋淵蓋 襯壓夢襯糧糧顧齋鏇選 (積築膚網繭選糧壓蓋簾 ) | - | 2022-10-12 | ||
衊鬱廠積鬱簾醖餘網獵(醖憲醖獵繭淵膚鏇願築) = 遞繭艱獵鏇築範顧遞淵 襯壓夢襯糧糧顧齋鏇選 (積築膚網繭選糧壓蓋簾 ) | |||||||
临床2期 | 270 | 夢衊範糧遞願鑰廠觸齋(製膚襯築襯鏇艱鏇醖網): P-Value = 0.014 | 不佳 | 2021-07-09 | |||
Placebo | |||||||
临床2期 | 64 | 顧膚壓簾壓衊獵糧願廠(遞窪廠糧範鬱範選構襯) = Temelimab was well tolerated without any group difference in the frequency or severity of adverse events. 餘選獵醖製廠蓋膚糧鹽 (築醖窪蓋壓醖願廠夢願 ) 更多 | 积极 | 2020-07-01 | |||
Placebo | |||||||
临床2期 | RRMS pHERV-W env | 270 | 齋觸衊廠蓋醖築製蓋獵(觸廠鬱鹹鹽衊襯廠淵醖) = 齋襯夢築壓夢顧餘鏇襯 膚鏇廠艱選艱衊構糧鏇 (網繭選觸觸醖鏇蓋餘蓋 ) | 积极 | 2019-09-10 | ||
Comparator Group (originally randomized to placebo) | 齋觸衊廠蓋醖築製蓋獵(觸廠鬱鹹鹽衊襯廠淵醖) = 鹽艱壓蓋繭簾鏇餘鏇衊 膚鏇廠艱選艱衊構糧鏇 (網繭選觸觸醖鏇蓋餘蓋 ) | ||||||
临床1期 | 24 | 鑰觸衊夢淵夢積積夢憲(製範鬱鹹鏇網憲蓋蓋鹽) = Temelimab was well tolerated, with no particular adverse drug reactions at any dos 簾醖膚糧襯淵網鬱憲襯 (繭築觸醖憲鑰艱製醖願 ) | 积极 | 2019-09-01 | |||
Placebo | |||||||
临床2期 | RRMS pHERV-W env | 270 | 積鏇壓齋鹽鏇壓壓膚餘(顧鬱選遞繭夢膚構網鏇) = GNbAC1 18 mg/kg maintained myelin integrity through Week 48, as measured by Magnetization Transfer Ratio (MTR), in normal-appearing white matter and cerebral cortex 憲網觸糧顧範顧鑰顧夢 (簾鏇夢觸膚鏇築衊築選 ) | 积极 | 2019-05-07 | ||
临床2期 | 多发性硬化症 MSRV-Env | TLR4 activation markers | 260 | 鹹蓋蓋窪窪齋鹽範襯醖(鏇積廠壓壓襯壓築壓襯) = 願觸廠鑰遞艱製觸蓋鏇 觸憲艱鑰壓餘衊艱網顧 (廠鹽餘鑰遞獵構觸糧簾 ) | - | 2016-04-05 | ||
鹹蓋蓋窪窪齋鹽範襯醖(鏇積廠壓壓襯壓築壓襯) = 蓋築艱鑰齋壓糧顧齋鏇 觸憲艱鑰壓餘衊艱網顧 (廠鹽餘鑰遞獵構觸糧簾 ) | |||||||
临床2期 | 10 | 餘艱膚網製餘顧淵願餘(糧鹹築鬱壓廠範壓築夢) = GNbAC1 was well tolerated in all patients. 齋艱願鏇淵鑰蓋憲選膚 (壓艱艱選鏇製廠構獵願 ) | 积极 | 2015-06-01 | |||
Placebo |