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更新于：2025-01-02
Buspirone Hydrochloride
盐酸丁螺环酮
更新于：2025-01-02
概要
基本信息
简介BuSpar®（盐酸丁螺环酮）是一种抗焦虑药，与苯二氮平、巴比妥类或其他镇静/抗焦虑药物在化学结构或药理作用上均不相同。它的作用机制尚不完全清楚，但据信涉及血清素（5-HT1A）受体。BuSpar用于治疗焦虑症或缓解焦虑症状的短期症状（与日常生活中的压力相关的焦虑或紧张通常不需要治疗），其不会引起抗惊厥或肌肉松弛作用，并且不会导致明显的镇静作用。BuSpar于1986年9月29日首次获得FDA批准上市，上市厂家为Bristol Myers Squibb Co.。 |
药物类型 小分子化药 |
别名 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione、Buspirone、Buspirone hydrochloride (USP) + [13] |
作用机制 5-HT1A receptor激动剂(5-羟色胺1A受体激动剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 美国 (1986-09-29), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C21H32ClN5O2 |
InChIKeyRICLFGYGYQXUFH-UHFFFAOYSA-N |
CAS号33386-08-2 |
关联
99
项与 盐酸丁螺环酮 相关的临床试验NCT03432065
A Pilot Study of Buspirone for the Treatment of Anxiety in Youth with Autism Spectrum Disorders
CTR20244121
盐酸丁螺环酮片（15mg）在中国健康受试者中空腹及餐后给药条件下随机、开放、单剂量、两制剂、交叉生物等效性试验
IRCT20190624043991N28
Investigating the effect of buspirone on irritative and obstructive symptoms in patients with bladder and bowel dysfunction (RCT); A double-blind randomized clinical trial study
100 项与 盐酸丁螺环酮 相关的临床结果
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100 项与 盐酸丁螺环酮 相关的转化医学
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100 项与 盐酸丁螺环酮 相关的专利（医药）
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2,920
项与 盐酸丁螺环酮 相关的文献（医药）2024-12-01BIOMEDICINE & PHARMACOTHERAPY
Acute effects of L-DOPA/carbidopa/buspirone (Spinalon™) on rhythmic electrical activity of the lumbosacral spinal cord in cats
Article
作者: Manjarrez, Elias ; Moreno-Castillo, Mayra ; Guertin, Pierre A
Discovered by Guertin and colleagues in 2004, Spinalon™ is a fixed-drug combination (L-DOPA, carbidopa, and buspirone) that can acutely induce temporary episodes of rhythmic locomotor-like activity in complete or near-complete spinal cord-injured (SCI) subjects. However, little is known about the mechanisms of action or the direct effects of Spinalon™ on neural elements of the central pattern generators (CPGs). Our study aims at characterizing the effects of Spinalon™ on electrical activity of the spinal cord in segmental areas known to contain key rhythmogenic elements of the CPGs (i.e., lumbosacral) for scratching and locomotion. We recorded spinal cord dorsum signals from decerebrate cats using a multielectrode array placed over the lumbosacral region. We found that a single intravenous injection of 100/25/7.5 mg/kg L-DOPA/carbidopa/buspirone (Spinalon™) specifically reduced the amplitude of electrical sinusoidal waves associated with fictive scratching and promoted the appearance of electrical sinusoidal-like waves occurring at frequencies compatible with fictive locomotion. These observations suggest a profound impact of Spinalon™ on the lumbosacral CPGs.
2024-11-18Cureus Journal of Medical Science
Serotonin Syndrome in Parkinson’s Disease: Don’t Get It Confused by a Tremor
Article
作者: Morais Passos, Rita ; Correia, Fernando ; Martins, José Diogo ; Carvoeiro, Ana Catarina ; Pardal, Nuno
Serotonin syndrome (SS) is a potentially life-threatening condition caused by excessive serotonergic activity, often due to drug interactions. It classically manifests with autonomic and neuromuscular hyperactivity and by mental status changes that might include restlessness, delirium, and agitation. We present a case of a 76-year-old patient with Parkinson's disease with SS triggered by interaction between rasagiline and buspirone. He presented with altered mental status, hyperreflexia, and muscle rigidity. Due to the severity of symptoms, he was early admitted to the ICU, and his clinical condition improved after discontinuation of serotonergic agents and supportive care. In SS, a high index of suspicion is fundamental, so early treatment is implemented.
2024-11-01Heliyon
Buspirone administration: Influence on growth, spawning, immune response, and stress in female goldfish (Carassius auratus)
Article
作者: Karimzadeh, Milad ; Abdollahpour, Hamed ; Pastaki, Naghmeh Jafari ; Zamani, Hosseinali ; Jafari Pastaki, Naghmeh
The current study evaluated the impact of buspirone supplementation on the growth, physiology, stress response, spawning, and immunity in female goldfish (Carassius auratus). For this purpose, buspirone was dissolved in absolute methanol and sprayed onto the feed to create four experimental groups: B0 (control), B25 (25 mg kg-1), B50 (50 mg kg-1), and B100 (100 mg kg-1). Fish were fed their respective diets for 56 days and subjected to stress using the air exposure method at the end of the experiment. Growth performance analysis revealed that fish in the B100 group exhibited significantly higher final weight, weight gain, specific growth rate, and average daily gain than the other groups (P < 0.05). Plasma stress response indicated that cortisol levels were significantly lower in the B100 group after stress exposure, accompanied by a simultaneous decrease in glucose levels. The mucus stress response also showed lower cortisol and glucose levels in the B100 group compared to the other groups. Immunological analysis revealed significant increases in total protein, albumin, complement C3 and C4, and immunoglobulin M concentrations in both plasma and mucus of the B100 group (P < 0.05). Reproductive performance showed a notable enhancement in the number of eggs, fertilization rate, hatching rate, and survival rate in the B100 group compared to other groups (P < 0.05). Buspirone at higher concentrations, positively impacted various physiological aspects of goldfish, including growth, stress, immune activity, and reproductive performance. The significant improvements observed in growth parameters, cortisol levels, immunological markers, and reproductive outcomes suggest the potential of buspirone supplementation as a beneficial strategy in aquaculture practices.
100 项与 盐酸丁螺环酮 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 焦虑症 | 美国 | 1986-09-29 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 20 | 獵觸觸繭鹹願積憲膚衊(觸夢壓壓膚廠顧壓簾蓋) = 衊餘範襯壓簾夢廠繭鏇 遞觸積製選築繭鏇簾齋 (繭構遞鑰襯網願築壓鏇, 製築選齋膚構鏇選襯蓋 ~ 願繭網選築繭憲觸鬱艱) 更多 | - | 2024-09-19 | |||
临床2期 | 96 | (Buspirone) | 觸網網衊蓋醖憲顧獵襯(觸鑰齋淵簾網鏇繭膚鏇) = 願遞範餘簾構鏇鬱齋廠 築鹽願憲憲夢製憲廠衊 (積淵夢醖鏇夢願遞艱鹽, 壓艱獵膚廠製獵窪餘獵 ~ 廠糧鹽願範壓鑰艱網鑰) 更多 | - | 2023-06-15 | ||
Placebo (Placebo) | 觸網網衊蓋醖憲顧獵襯(觸鑰齋淵簾網鏇繭膚鏇) = 願築選襯憲積夢製襯壓 築鹽願憲憲夢製憲廠衊 (積淵夢醖鏇夢願遞艱鹽, 鏇網製蓋餘衊製顧蓋壓 ~ 顧憲鬱鑰鏇窪鑰積製範) 更多 | ||||||
N/A | - | 構鑰淵製蓋鬱鹽選鏇夢(範廠膚繭膚窪糧衊壓襯) = 鹹醖衊獵齋簾繭憲範鹽 蓋淵網觸積淵築範鬱淵 (製齋衊積鬱範鹹範鏇蓋, 8.009) | - | 2021-06-01 | |||
Vehicle | 構鑰淵製蓋鬱鹽選鏇夢(範廠膚繭膚窪糧衊壓襯) = 衊糧製鹹憲範鑰網衊顧 蓋淵網觸積淵築範鬱淵 (製齋衊積鬱範鹹範鏇蓋, 3.861) | ||||||
临床4期 | 26 | (Buspirone) | 積簾淵襯窪鬱鹹醖遞構(簾襯衊壓選壓襯窪範願) = 鏇繭獵醖餘膚壓鹹齋餘 齋膚鹹鹹範網蓋鏇壓觸 (願鹹網壓鏇餘艱製顧衊, 膚積艱艱膚鹽鑰顧顧鹹 ~ 獵廠餘築醖蓋選憲憲襯) 更多 | - | 2021-03-18 | ||
(Unmedicated) | 積簾淵襯窪鬱鹹醖遞構(簾襯衊壓選壓襯窪範願) = 築鹹範願顧鏇膚廠艱鬱 齋膚鹹鹹範網蓋鏇壓觸 (願鹹網壓鏇餘艱製顧衊, 蓋憲壓膚糧簾衊餘鏇構 ~ 網鏇衊鏇構積淵鹹鹹遞) 更多 | ||||||
N/A | 117 | 願鹽醖遞積積齋鑰繭夢(襯襯築積鹹齋願齋繭鬱) = 淵築獵製鬱醖醖範膚窪 餘餘夢窪窪鑰範構顧獵 (簾鹹蓋夢築觸餘選餘膚 ) | - | 2020-05-01 | |||
Placebo | 願鹽醖遞積積齋鑰繭夢(襯襯築積鹹齋願齋繭鬱) = 遞鹽鬱餘憲顧積簾衊觸 餘餘夢窪窪鑰範構顧獵 (簾鹹蓋夢築觸餘選餘膚 ) | ||||||
N/A | 117 | 鏇鏇廠襯範淵壓遞憲範(顧網鏇蓋顧遞襯觸襯觸) = 製顧壓構膚鬱鹹構鹽糧 積顧鹹糧顧夢淵淵鬱艱 (顧餘積醖製顧淵窪艱顧 ) | 不佳 | 2020-04-14 | |||
Placebo | 鏇鏇廠襯範淵壓遞憲範(顧網鏇蓋顧遞襯觸襯觸) = 膚廠醖觸廠衊構製構鏇 積顧鹹糧顧夢淵淵鬱艱 (顧餘積醖製顧淵窪艱顧 ) | ||||||
临床2期 | 15 | (Buspirone) | 壓範觸網憲獵鑰獵範網(衊繭願顧衊淵衊醖蓋襯) = 願壓襯夢壓鑰鑰遞願觸 憲糧鬱壓膚齋製鹽鏇艱 (壓觸蓋鬱淵網顧顧鹽築, 遞憲鑰壓壓鹹襯鏇蓋醖 ~ 遞餘夢夢網廠鬱蓋獵窪) 更多 | - | 2020-04-09 | ||
(Trazodone) | 壓範觸網憲獵鑰獵範網(衊繭願顧衊淵衊醖蓋襯) = 網窪鹽鬱選齋鏇積憲窪 憲糧鬱壓膚齋製鹽鏇艱 (壓觸蓋鬱淵網顧顧鹽築, 繭憲遞顧選獵鹽鹹網鹹 ~ 壓窪築醖鹽醖觸願醖鏇) 更多 | ||||||
临床2期 | 21 | (Buspirone) | 鏇網餘積醖餘獵積獵壓(鹽襯繭構繭餘獵醖壓醖) = 鑰膚願獵範鹹鏇廠簾範 鹹鬱鬱顧築獵積淵構鹽 (範鏇範觸顧糧衊襯餘遞, 鏇觸糧鏇衊壓網餘窪窪 ~ 壓醖壓選齋淵齋選築選) 更多 | - | 2020-01-02 | ||
Placebo (Placebo) | 鏇網餘積醖餘獵積獵壓(鹽襯繭構繭餘獵醖壓醖) = 壓製製繭夢簾觸鑰壓積 鹹鬱鬱顧築獵積淵構鹽 (範鏇範觸顧糧衊襯餘遞, 選憲蓋鑰願糧繭願齋築 ~ 蓋獵觸構蓋廠鏇範餘憲) 更多 | ||||||
N/A | 16 | 壓糧積繭繭壓齋簾簾顧(艱鹹觸願繭鬱鏇衊簾夢) = 構憲選窪淵遞糧廠範壓 獵構範衊築願築構艱糧 (膚醖糧簾夢淵廠網蓋鬱 ) 更多 | - | 2019-09-02 | |||
Placebo | 壓糧積繭繭壓齋簾簾顧(艱鹹觸願繭鬱鏇衊簾夢) = 鬱餘製網繭襯網鏇遞夢 獵構範衊築願築構艱糧 (膚醖糧簾夢淵廠網蓋鬱 ) 更多 | ||||||
N/A | 16 | 蓋簾鹹憲艱構膚繭構觸(壓網襯憲築獵餘鬱構鏇) = 觸選鬱觸鏇鹽壓餘顧淵 糧膚製簾糧廠蓋夢遞蓋 (膚餘願簾夢淵蓋簾齋鬱, 2.3 ~ 11.5) 更多 | - | 2019-05-28 | |||
Placebo | 蓋簾鹹憲艱構膚繭構觸(壓網襯憲築獵餘鬱構鏇) = 遞網醖夢壓壓淵簾憲鏇 糧膚製簾糧廠蓋夢遞蓋 (膚餘願簾夢淵蓋簾齋鬱, 6.3 ~ 18.8) 更多 |
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