D-Serine(D-Serine) - 药物靶点：NMDA receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

D Serine

靶点

NMDA receptor

作用方式

激动剂

作用机制

NMDA receptor激动剂(谷氨酸[NMDA]受体复合体激动剂)

治疗领域

神经系统疾病内分泌与代谢疾病其他疾病

在研适应症-

非在研适应症

慢性精神分裂症帕金森病分裂情感性障碍+ [2]

原研机构

Mass General Brigham, Inc.

在研机构-

非在研机构

Nathan S. Kline Institute for Psychiatric Research

Bausch Health Cos., Inc.

Mass General Brigham, Inc.

+ [5]

权益机构

Prestwick Pharmaceuticals, Inc.Biovail Corp.

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C3H7NO3

InChIKeyMTCFGRXMJLQNBG-UWTATZPHSA-N

CAS号312-84-5

关联

14

项与 D-Serine 相关的临床试验

NCT06876129

/ Not yet recruiting临床1期IIT

Pharmacologic Augmentation of TMS for Depression with D-serine

The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions of rTMS will produce greater clinical outcomes than iTBS with placebo and 18-Hz with placebo.

开始日期2025-04-01

申办/合作机构

McLean Hospital, Inc.

NCT04140773

/ TerminatedN/AIIT

The Effect of D-serine as add-on Therapy in Recent-onset Psychosis

In psychotic disorders, negative symptoms and cognitive impairment are difficult to treat with antipsychotics, which are mostly effective for positive symptoms. However, it is important that negative symptoms and cognitive impairment are treated as well, as they both play a large part in the acute episode and long-term course of schizophrenia outcome. Previous studies have used D-serine as add-on treatment in patients with psy-chotic disorders and high-risk patients, with positive results. So far, no study has investigated the effects in a sample of recent-onset psychosis patients.
Therefore, this study will include 30 patients (18-50 years old) with recent-onset psychosis. In addition to their regular treatment, patients will receive either D-serine (2 g/d) or placebo for 6 weeks. D-serine is an amino-acid naturally occurring in the brain which is prescription-free available as nutritional supplement.
The primary outcome measure is total score on the Positive and Negative Syndrome Scale (PANSS). Secondary measure-ments include PANSS subscales, neurocognitive tests, (f)MRI, and EEG

开始日期2021-11-25

申办/合作机构

University of Basel

NCT04721249

/ CompletedN/AIIT

A Randomized add-on Trial of D-serine for Depression

The glutamate system is emerging as target for the development of novel antidepressant medication, in particular compounds modulating the NMDA receptor. While the NMDA receptor antagonist ketamine is an effective option for many treatment-restistant patients, it is also accompanied by dissociative and cognitive effects and also bears the risk to develop addiction, side effects that are significantly restricting its clinical utility. There is now compelling evidence of the antidepressant potential of D-serine, a NMDAR co-agonist. Compared to ketamine, D-serine goes along without any psychotomimetic effects or other side effects and thus might be a prom-ising novel antidepressant.
This study represents the first randomized control trial to test the efficacy of D-serine as an adjuvant therapy in patients with depression and thereby adds to re-cent efforts to establish novel glutamatergic antidepressants. Besides clinical measures, this study also explores the biological mechanisms underlying D-serine's clinical effect.

开始日期2021-07-01

申办/合作机构

University of Basel

100 项与 D-Serine 相关的临床结果

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100 项与 D-Serine 相关的转化医学

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100 项与 D-Serine 相关的专利（医药）

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3,494

项与 D-Serine 相关的文献（医药）

2025-08-01·DYES AND PIGMENTS

A fluorescent probe for enantioselective recognition of amino acids in solutions, cells and zebrafishes

作者: Huang, Zong-Xing ; Ni, Chuan-Zhi ; Sun, Qi ; Zhu, Yuan-Yuan ; Gu, Shuang-Xi ; Fu, Shi-Wei ; Zhang, Fang-Qi ; Li, Yang

Binaphthyl-based chiral fluorescent probes (S)-/(R)-1 featuring a 2-methylthiophenimide unit were designed and synthesized.The fluorescent response to enantiomer pairs of amino acids revealed that (S)- and (R)-enantimer of the probe had chiral bias to L- and D-amino acids, resp.The compound (S)-1 showed outstanding enantioselective fluorescence enhancement toward 10 amino acids (Asn, Glu, Val, Leu, Met, Ser, Gln, Arg, Phe and Ala) in both solvents of EtOH/H2O and DMSO/H2O at the condition of pH 7.5.Extremely high enantiomeric fluorescence enhancement ratio (ef, [IL-I0]/[ID-I0]) were obtained for Asn (646.2), Glu (318.9), Val (255.6), Leu (252.4), Thr (223.9) in EtOH/H2O, and the ef values to Val, Ala, Ser, Glu, Arg, Gln were all larger than 20 in DMSO/H2O.Chiral fluorescent imaging of the four amino acids (Ser, Val, Arg and Gln) were obtained in both living cells and zebrafishes via the probe (R)-1, which provides a new concept for the diagnosis and treatment of diseases associated with amino acid racemization.Results of 1H NMR and HRMS revealed the enantioselective fluorescence enhancement mechanism.

2025-08-01·DYES AND PIGMENTS

Tetraphenylethylene based chiral AIEgen for enantioselective detection of chiral acids

作者: Wei, Keyue ; Feng, Hai-Tao ; Zhang, Wangyan ; Li, Qingyang ; Zhang, Xiuhua ; Chen, Miao-Miao ; Qi, Chunxuan ; Zhao, Weiwei

Enantioselective recognition is crucial in pharmaceutical anal. and life sciences but remains a significant challenge.Herein, we constructed two chiral probes named (1R, 2R)-CHDA-2TPE and (1S, 2S)-CHDA-2TPE, which exhibit typical aggregation-induced emission (AIE) properties.The chiral probes show high enantioselectivity to 11 kinds of chiral reagents.Notably, the fluorescence intensity ratio of the probe with L- and D-glutamic acid was up to 88.8.The ¹H NMR titration results suggested that the hydrogen bond is response for the recognition.These findings implied that the synthesized probes are promising candidates for analyzing chiral compounds

2025-07-01·SEPARATION AND PURIFICATION TECHNOLOGY

Direct crystallization resolution of chiral compounds assisted by chiral ionic liquids through conformational matching

作者: Wang, Mingyang ; Wang, Jingtao ; Luo, Dawei ; Gong, Junbo ; Wang, Dongbo ; Sang, Jingting ; Zhang, Bowen ; Han, Dandan

Stereoselective recognition using "tailor-made" chiral ionic liquids (CILs) is an effective approach to obtaining enantiopure compounds through crystallization resolutionIn this study, CILs were used as additives to stereoselectively inhibit the nucleation and growth of unwanted enantiomers via a conformational matching mechanism.Interestingly, a cosolvency phenomenon was found in the threonine-CILs-ethanol solvent system.Based on this, an enhanced stereoselective crystallization resolution strategy that combines ultrasound and cosolvency was proposed.The goal of this strategy was to improve the crystallization yield and enantiomeric purity.The results showed that the crystallization resolution yield of the cosolvency system was 33.43%, higher than that of the pure water system (13.56%).More importantly, the introduction of ultrasonic enhancement further increased the crystallization resolution yield to 39.45%.This work will facilitate the exploration of the unlimited potential of utilizing the cosolvency phenomenon and ultrasonic enhancement for crystallization resolution

100 项与 D-Serine 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	D-Serine	-	DB03929

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
分裂情感性障碍	临床3期	印度	Yale University	2005-02-01
精神分裂症	临床3期	印度	Yale University	2005-02-01
慢性精神分裂症	临床2期	中国台湾	中国医药大学附设医院	2005-01-01
帕金森病	临床2期	-	Bausch Health Cos., Inc.	-
帕金森病	临床2期	-	Mass General Brigham, Inc.	-
创伤后应激障碍	临床2期	-	Bausch Health Cos., Inc.	-
创伤后应激障碍	临床2期	-	Mass General Brigham, Inc.	-

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00817336 (CTgov)	临床2期	分裂情感性障碍 \| 精神分裂症	16	D Serine (D-serine)	淵膚衊壓觸糧壓觸蓋鬱(廠繭蓋衊鏇襯廠淵衊憲) = 鑰膚鏇網廠廠繭膚構顧鏇繭廠獵憲鑰艱鑰觸鬱 (製製網構糧蓋壓獵繭範, 9.3) 更多	-	2017-08-02
				Placebo (Placebo)	淵膚衊壓觸糧壓觸蓋鬱(廠繭蓋衊鏇襯廠淵衊憲) = 壓廠壓顧糧選願糧範鏇鏇繭廠獵憲鑰艱鑰觸鬱 (製製網構糧蓋壓獵繭範, 10.3) 更多