核黄素四丁酸酯(Riboflavin Butyrate) - 在研适应症：高胆固醇血症，核黄素缺乏_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Riboflavin 2',3',4',5'-tetrabutyrate、Riboflavin Tetabutyrate、Riboflavin butyrate (JP17)

+ [6]

靶点-

作用方式-

作用机制-

治疗领域

内分泌与代谢疾病

在研适应症

高胆固醇血症核黄素缺乏

非在研适应症-

原研机构

Mitsubishi Tanabe Pharma Corp.

在研机构

Nipro ES Pharma KK

成都利尔药业有限公司

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1979-09-28),

高胆固醇血症核黄素缺乏

最高研发阶段(中国)批准上市

特殊审评-

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结构/序列

分子式C33H44N4O10

InChIKeyMJNIWUJSIGSWKK-BBANNHEPSA-N

CAS号752-56-7

关联

33

项与核黄素四丁酸酯相关的临床试验

NCT06100952

/ Active, not recruiting临床3期

A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age with Keratoconus (APRICITY-B)

A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus

开始日期2023-11-01

申办/合作机构

Epion Therapeutics, Inc.

NCT05027295

/ Recruiting临床3期

A Randomized Study to Evaluate the Safety and Efficacy of Corneal Collagen Crosslinking Performed With Continuous vs Pulsed UVA Light for Reducing Corneal Curvature in Eyes With Keratoconus and Post-refractive Corneal Ectasia

Corneal collagen crosslinking has been demonstrated as an effective method of reducing progression of both keratoconus and post-refractive corneal ectasia, as well as decreasing the steepness of the cornea in these pathologies.
Performing an accelerated CXL procedure with pulsed UVA light may increase the oxygenation of the cornea, which may improve the crosslinking efficacy.

开始日期2021-07-30

申办/合作机构-

NCT04905108

/ Recruiting临床3期

Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking Using Two Different Riboflavin Administration Protocols

Corneal collagen crosslinking (CXL) has been demonstrated as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these pathologies. Transepithelial crosslinking in which the epithelium is not removed has been proposed to offer a number of advantages over traditional crosslinking including an increased safety profile by reducing the risk for infection and scarring, faster visual recovery and improved patient comfort in the early postoperative healing period.

开始日期2021-06-02

申办/合作机构-

100 项与核黄素四丁酸酯相关的临床结果

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100 项与核黄素四丁酸酯相关的转化医学

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100 项与核黄素四丁酸酯相关的专利（医药）

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317

项与核黄素四丁酸酯相关的文献（医药）

2023-04-01·International Journal of Food Science & Technology

Nanoemulsions loaded with compound photosensitisers: synergistic photodynamic inactivation effects of curcumin and riboflavin tetra butyrate

作者: Zhuang, Hong ; Yuan, Yuan ; Fang, Qiangsheng ; Zhang, Yushu ; Li, Rui ; Zhang, Chunling

SummaryAntimicrobial photodynamic therapy (aPDT) is an effective method in the field of sterilisation. Singlet oxygen (1O2) is an important substance in photodynamic sterilisation that needs to be detected. It involves energy transfer from an excited photosensitiser to surrounding oxygen molecules to produce cytotoxic 1O2 species, a process termed as type II reaction. Traditional photodynamic sterilisation for fresh produce generally involves only a single photosensitiser and uses nanoemulsions coating to make the photosensitiser work better. This allows the emulsion to produce only a limited amount of reactive oxygen species (ROS) in the presence of light, such that the bactericidal effect is limited. We have innovatively compounded two photosensitisers and stored them as nanoemulsions. The composite photosensitiser produces relatively higher ROS and the nanoemulsions have good stability as well as rheological properties, and the photosensitisers are well coated in the emulsions. In summary, nanoemulsions based on composite photosensitisers showed synergistic activity in controlling the growth of Staphylococcus aureus, which provides a novel approach for raw sterilisation to maintain food safety.

2023-01-18·Chemistry – A European Journal

Multistimuli‐Responsive Chromism of Vinylene‐Linked Bisflavin Based on the Aggregation and Redox Properties

Article

作者: Okamoto, Koyo ; Li, Zimeng ; Kawamorita, Soichiro ; Naota, Takeshi

AbstractMultistimuli‐responsive chromism was observed for vinylene‐linked bisflavin 1 a with an extended π‐conjugated platform. The yellow emission of a dilute solution of 1 a in CHCl3 (0.2 mM) observed at 298 K under UV excitation was changed to orange or red emission upon (1) an increase of concentration, (2) a decrease of temperature, and (3) variation of the solvent. This is in contrast to the almost non stimuli‐responsive chromism of the N‐methylated bisflavin analogue 1 b and monoflavin 2 a. Mechanistic investigation by 1H NMR analysis under various conditions revealed that the extended π‐conjugation platform and imide moiety of 1 a generate controllability in the formation of lower‐ and higher‐ordered aggregates, which induce variation of the emission color upon change. Bisflavin 1 a also exhibited redox‐induced chromism, where the orange emission of 1 a was quenched by the addition of hydrazine under anaerobic conditions, and changed back to the original emission upon subsequent bubbling of O2 gas.

2022-08-16·ACS Macro Letters

Versatile Method of Generating Triboluminescence in Polymer Films Blended with Common Luminophores

Article

作者: Khusnutdinova, Julia R. ; Fayzullin, Robert R. ; Karimata, Ayumu

Herein we report a versatile method for the preparation of triboluminescent polymer films by physical blending with common luminophores. This method does not require the presence of a crystalline phase or the use of materials known to be triboluminescent. Emission is generated in response to friction of the polymer surface via triboelectrification, either by rubbing directly or through an inert coating layer, even with low applied stress (<0.1 MPa). Our findings offer a convenient and practical method of preparation of triboluminescent, amorphous polymer films with easily tunable emission properties.

100 项与核黄素四丁酸酯相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01913	-	S01XA26	DB14727

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
高胆固醇血症	日本	Nipro ES Pharma KK	1979-09-28
核黄素缺乏	日本	Nipro ES Pharma KK	1979-09-28

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00674661 (CXL, CTgov)	临床3期	角膜扩张	130	UVA Irradiation+riboflavin ophthalmic solution (Corneal Collagen Cross-linking (CXL) Treatment Group)	憲選衊齋顧餘襯顧鏇製(齋齋簾願齋顧艱餘網餘) = 顧餘憲廠選壓憲繭繭蓋蓋觸壓積憲壓願鹽遞憲 (簾範製鹹蓋齋廠夢鹽鏇, 憲壓衊顧顧窪製齋觸鑰 ~ 糧衊築壓鹹夢構艱範簾) 更多	-	2017-01-27
				riboflavin ophthalmic solution (Control Group)	憲選衊齋顧餘襯顧鏇製(齋齋簾願齋顧艱餘網餘) = 範憲積淵窪顧網構艱餘蓋觸壓積憲壓願鹽遞憲 (簾範製鹹蓋齋廠夢鹽鏇, 夢獵鏇範範夢窪齋鏇鏇 ~ 鏇淵積淵製膚壓壓鹽餘) 更多
NCT00647699 (CXL, CTgov)	临床3期	圆锥角膜	147	UVA Irradiation+riboflavin ophthalmic solution (Corneal Collagen Cross-linking (CXL) Treatment Group)	鹹願醖窪壓繭糧廠餘網(廠範醖網簾網壓鹽膚鹽) = 鏇製鹽獵窪鏇鑰衊繭觸積襯遞醖衊夢衊襯遞簾 (壓夢獵鹹遞膚鑰壓鑰壓, 製繭顧鹹鬱衊簾鑰醖製 ~ 製觸製窪範選淵網選顧) 更多	-	2016-07-07
				riboflavin ophthalmic solution (Control Group)	鹹願醖窪壓繭糧廠餘網(廠範醖網簾網壓鹽膚鹽) = 製觸觸願構選鹹窪夢選積襯遞醖衊夢衊襯遞簾 (壓夢獵鹹遞膚鑰壓鑰壓, 鹽襯窪鏇蓋齋壓顧網觸 ~ 鏇鏇製憲積壓鹹鬱糧遞) 更多
NCT01190306 (CTgov)	临床3期	圆锥角膜	127	The VEGA UV-A Illumination System+Riboflavin (CXL Treatment)	繭範廠鑰製夢淵繭壓襯(夢餘鑰獵獵襯願夢夢鬱) = 齋獵壓鹽觸憲壓鑰鏇艱觸簾築築範築觸繭襯襯 (鏇遞衊積獵鑰鹽遞網簾, 鑰廠膚廠鏇廠壓蓋鹽網 ~ 鑰積範餘鏇簾齋蓋鑰遞) 更多	-	2013-03-04
				Riboflavin (Sham Control)	繭範廠鑰製夢淵繭壓襯(夢餘鑰獵獵襯願夢夢鬱) = 餘淵遞鹹繭醖鑰鬱餘構觸簾築築範築觸繭襯襯 (鏇遞衊積獵鑰鹽遞網簾, 憲艱鏇艱選餘構網廠廠 ~ 簾蓋觸網願襯鑰觸齋窪) 更多
NCT01398839 (CTgov)	临床3期	-	103	VEGA UV-A Illumination System+Riboflavin (CXL Treatment)	膚製觸襯糧構範觸鬱願(鬱蓋獵鹹範遞構顧鹹顧) = 繭醖願艱廠艱廠衊製蓋築鹹膚鑰糧襯壓觸壓衊 (衊鬱鏇淵齋範鑰糧鬱鹽, 積鹹艱積簾鹽餘鹹壓鹽 ~ 網醖窪鏇簾積蓋獵糧網) 更多	-	2013-03-04
				Riboflavin (Sham Control)	膚製觸襯糧構範觸鬱願(鬱蓋獵鹹範遞構顧鹹顧) = 衊網艱觸齋顧艱醖願糧築鹹膚鑰糧襯壓觸壓衊 (衊鬱鏇淵齋範鑰糧鬱鹽, 齋範選鹹艱壓簾衊糧廠 ~ 鑰艱壓淵簾鹹鬱鹹鹹顧) 更多