阿洛夫定(Alovudine) - 药物靶点：POLG x RT_在研适应症：急性髓性白血病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Alovudine (USAN/INN)、FLT、FddThd

+ [3]

靶点

POLG x RT

作用机制

POLG inhibitors(DNA polymerase gamma, catalytic subunit inhibitors)、RT抑制剂(逆转录酶抑制剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

University Health Network

Medivir AB

非在研机构

Pfizer Inc.

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C10H13FN2O4

InChIKeyUXCAQJAQSWSNPQ-XLPZGREQSA-N

CAS号25526-93-6

关联

18

项与阿洛夫定相关的临床试验

NCT03633955 / Recruiting临床1期IIT

Multi-institutional Prospective Pilot Study of Radiology Evaluation of Acute Leukemia Infiltration analyZed by Experimental Imaging

This is a prospective pilot study, the primary aim of which is to determine whether the presence of 18F FLT imaging signal uptake abnormalities correlate with clinically validated evidence of hematopoietic malignant disease (e.g. MRD, molecular, flow or histology) after immunotherapy and other treatments.

开始日期2023-01-19

申办/合作机构

University of Oklahoma

[+1]

NCT01410630 / CompletedN/AIIT

FLT-PET/CT vs FDG-PET/CT for Therapy Monitoring of Diffuse Large B-cell Lymphoma

A research study of a new method of visualizing internal organs called 18F-FLT PET/CT that yields better tracking of cancer treatment progress. PET/CT stands for positron emission tomography with low dose computed tomography and has been used for many years. 18F-FLT PET/CT uses a new tracer, fluorothymidine, which is taken up by cells that are actively proliferating or dividing such as cancer cells. We hope to learn whether this tracer is superior to the conventional tracer for monitoring treatment of diffuse large B-cell lymphoma (DLBCL).

开始日期2017-09-07

申办/合作机构

Jonsson Comprehensive Cancer Center

[+1]

JPRN-jRCTs051180147 / CompletedN/AIIT

FLT-PET/MRI imaging for the evaluation of early response to immune checkpoint inhibitors - FLT-PET/MRI imaging for the immune checkpoint inhibitors

开始日期2017-06-28

申办/合作机构-

100 项与阿洛夫定相关的临床结果

登录后查看更多信息

100 项与阿洛夫定相关的转化医学

登录后查看更多信息

100 项与阿洛夫定相关的专利（医药）

登录后查看更多信息

341

项与阿洛夫定相关的文献（医药）

2024-08-01·Heliyon

Utilization of technologies in French language translation (FLT) education in Saudi Arabia: A quantitative survey study

Article

作者: Al Fryan, Latefa Hamed

The utilization of educational technologies has become a mainstream issue in recent years, particularly in the post-pandemic era. The need for technologies and the procedures for implementing them is, therefore, increasingly becoming a core subject and an interesting area of research in foreign language instruction. The present research aimed to explore the utilization of technology in teaching and learning FLT at Princess Nourah University in Saudi Arabia. The research adopted a quantitative survey study based on the data collected from 169 students using a 48-item questionnaire. The results showed that the most used technologies by students are FLT learning videos on YouTube, browsing electronic sites, and searching educational sites. The findings also revealed that the most common technologies used by teachers include e-mail, learning management systems, and gamification. The least used technologies were artificial intelligence, Boostlingo, and Kahoot, which are considered more relevant to FLT instruction [30]. For FLT students, the most challenging obstacles in utilizing technologies were a lack of training on using relevant technologies and limited electronic sites supporting FLT learning. Amongst the recommendations that the researcher highlighted based on these study findings include the fact that students must still utilize more innovative technology relevant to FLT learning, as most of this technology is considered common. All recommendations highlighted aim to develop technology-based FLT teaching and learning in the College of Languages at PNU. For research ethics purposes, the researcher achieved Approval Exempt (IRB Log # 22-0348), date: 29/May 2023.

2024-07-01·Environmental Pollution

Effects of chemical composition of ambient PM2.5 measured in Seoul on potential health risks and generation of reactive oxygen species

Article

作者: Kim, Hwajin ; Park, Eun Ha

This study assesses the health effects associated with the chemical species of ambient particulate matter (PM) with an aerodynamic diameter ≤2.5 μm (PM_2.5) in Seoul, focusing on identifying key chemical constituents and their sources. We employed two approaches to estimate health risks: (1) evaluating carcinogenic and noncarcinogenic risks using IRIS (Integrated Risk Information System) data from the US EPA (Environmental Protection Agency), and (2) quantifying the generation of hydroxyl radicals (·OH) following exposure to PM_2.5 in surrogate lung fluid (SLF). Our results show a significant impact on human health from certain elements (Cr, Ni, As, and Cd) and polycyclic aromatic hydrocarbons (PAHs) (DaeP, DahA, and BaP for carcinogenic risks; BaP and BeP for noncarcinogenic risks). Notably, Cr and BaP, which are influential in both risk assessment and ·OH generation, highlight their significant roles in human health impacts. However, other components (e.g., CPP, BaP, BghiP, BaA, CHR, PYR, FLT, Ca, Mg, and Cu), though contributors to ·OH generation, were not included in the EPA's health risk assessment, suggesting a need for a broader PM_2.5 compositional analysis to more accurately determine exposure concentrations and assess inhalation risks. These components predominantly originate from anthropogenic sources, such as combustion, vehicles, and industrial activities, underscoring the significant health implications of the pollutants emitted from these sources. The study concluded that focusing solely on the mass reduction of PM_2.5 may not suffice; a dual approach that reduces both mass concentration and chemical-specific health risks is imperative for effective public health protection.

2024-06-01·Environmental Pollution

Effect of liming on polycyclic aromatic hydrocarbons leaching from hydrocarbon-contaminated tectogenic industriosol

Article

作者: Le Guet, Thibaut ; Dupuy, Fabrice ; Grybos, Malgorzata ; Martin, Nicolas ; Joussein, Emmanuel

Soil stabilization/solidification is commonly employed remediation method for contaminated soils. Until now, limited attention has been given to the application of quicklime in polycyclic aromatic hydrocarbons (PAHs) contaminated soil. We treated a tectogenic industriosol spiked with 50 mg kg^-1 of four PAHs (12.5 mg kg^-1 each of fluorene (FLU), phenanthrene (PHE), fluoranthene (FLT) and pyrene (PYR)) using three different liming agents at 1% (w:w): quicklime (CaO), hydrated lime (Ca(OH)₂) and carbonate calcium (CaCO₃). All treated samples were leached in water at a solid-liquid ratio of 10, with subsequent analysis of leached soil and leachates for PAHs content. Results revealed that the addition of liming agents led to a reduction in FLU and PHE concentrations in treated soil by 6.81 ± 2.47% and 28.88 ± 4.18%, respectively, compared to a not-treated sol. However, no significant impact was observed on the 4-cycles PAHs (FLT and PYR). The addition of liming agents also significantly decreased the amount of PAHs in the leachate, by 100% for FLU and PHE, and by 74.9 ± 17.5% and 72.3 ± 34.8%, for FLT and PYR, respectively, compared to not limed soil. Among the liming agents, quicklime was the most effective in reducing the amount of 4 cycles PAHs in the leachate. Various mechanisms, such as encapsulation, volatilization and oxidation could contribute to this observed reduction. Quicklime treatment at a concentration of 1% w:w in PAHs-contaminated soil emerges as a promising technique to effectively reduce PAHs concentration in soils and mitigate PAHs mobility through leaching. This study also sheds light on the possibility to limit CO₂ emissions and resources exploitation to assure the remediation process, thereby enhancing its overall environmental sustainability.

100 项与阿洛夫定相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D02830	阿洛夫定	-	DB06198

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
急性髓性白血病	临床前	加拿大	University Health Network	2017-12-07
急性髓性白血病	临床前	瑞典	Medivir AB	2017-12-07
HIV感染	临床前	瑞典	-	-
HIV感染	临床前	-	Pfizer Inc.	-
HIV感染	临床前	-	Medivir AB	-
HIV感染	临床前	法国	-	-
HIV感染	临床前	美国	-	-

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


IAS2002	N/A	-	15	MIV-310 7.5 mg	齋網齋網餘積窪繭鏇簾(鏇積製淵獵憲鹽積製願) = 襯簾簾鏇願範夢廠醖醖鹹觸醖鬱憲繭淵積積窪 (壓構遞鑰選鑰齋膚網齋 )	-	2002-01-01