预约演示
更新于：2025-03-28
Mirodenafil dihydrochloride
更新于：2025-03-28
概要
基本信息
原研机构 |
非在研机构- |
最高研发阶段临床3期 |
首次获批日期- |
最高研发阶段(中国)临床3期 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C8H11N |
InChIKeyRIWRFSMVIUAEBX-UHFFFAOYSA-N |
CAS号103-67-3 |
关联
3
项与 Mirodenafil dihydrochloride 相关的临床试验NCT05531526
A Phase 3 Double-blind, Randomized, Placebo-controlled, Multi-center Trial to Evaluate the Efficacy and Safety of AR1001 Over 52 Weeks in Participants with Early Alzheimer's Disease (Polaris-AD)
NCT03625622
A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate Efficacy and Safety of 26-Week Treatment of AR1001 in Patients With Mild to Moderate Alzheimer's Disease
CTR20244348
一项评价AR1001治疗早期阿尔茨海默病受试者持续52周的有效性和安全性的III期、双盲、随机、安慰剂对照、多中心试验
100 项与 Mirodenafil dihydrochloride 相关的临床结果
登录后查看更多信息
100 项与 Mirodenafil dihydrochloride 相关的转化医学
登录后查看更多信息
100 项与 Mirodenafil dihydrochloride 相关的专利（医药）
登录后查看更多信息
5,017
项与 Mirodenafil dihydrochloride 相关的文献（医药）2025-06-01SEPARATION AND PURIFICATION TECHNOLOGY
Energy-efficient CO2 capture using novel low-viscosity water-lean aromatic amine solvent MBA/BDMA/EG/H2O: Performance, mechanism and thermodynamics
作者: Chi, Shudan ; Yang, Linjun ; Li, Wenrui ; Yu, Hang ; Hou, Dawei ; Wang, Xin ; Jin, Lijian ; Yang, Hangqi ; Kong, Sining ; Hou, Xueyan
To address the challenges of high regeneration energy and corrosion in traditional mixed amine absorbents, as well as the increased viscosity issues in water-lean absorbents post-saturation, this study introduces the co-solvent ethylene glycol (EG) to replace part of the water in the high stability N-methylbenzylamine (MBA) and N, N-dimethylbenzylamine (BDMA) systems, resulting in a novel water-lean aromatic amine solvent, MBA/BDMA/EG/H2O, is proposed as an alternative solutionThe addition of the tertiary amine BDMA significantly enhanced the regeneration efficiency of the absorbent.When the mass ratio of MBA/BDMA/EG/H2O is set at 1.5:1.5:3.5:3.5, the CO2 loading reaches 0.36 mol/mol, while the viscosity is only 10.82 mPa·s at room temperatureThe CO2 capture mechanism of this absorbent was elucidated using 13C NMR and quantum chem. calculationsInitially, CO2 reacts with MBA to form MBACOO-/MBAH+.Subsequently, MBA+COO- undergoes deprotonation to produce MBAH+ and BDMAH+.As the concentration of free MBA decreases to a certain level, BDMA undergoes hydrolysis, resulting in the formation of HCO-3.In the later stages of absorption, some of the carbamate products convert to unstable alkyl carbonates by reaction with EG.Notably, the regeneration energy of MBEH is reduced by 21.1% (estimate), compared to 30% MEA aqueous solutionThe corrosion rate of 30% MEA (after absorption) on carbon steel is 3.6 times higher than that of MBEH (after absorption).Therefore, the proposed MBEH solution presents a promising absorbent with excellent desorption performance, low viscosity, reduced regeneration energy, and low corrosion rate.
2025-04-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Effects of silica nanoparticle addition and PDMS coating on membrane performance and stability in the extraction of aromatic amines
Article
作者: Luis, Patricia ; Garcia-Chirino, Julieta ; Van Eygen, Gilles ; Gilles, Amaury ; Van der Bruggen, Bart ; Buekenhoudt, Anita ; Baylan, Nilay
This study investigates novel strategies to improve membrane performance and stability in the extraction of aromatic amines for chiral amine production. The effects of silica nanoparticle addition and polydimethylsiloxane (PDMS) coating were explored, with a focus on the selective extraction of α-methylbenzylamine (MBA) and 1-methyl-3-phenylpropylamine (MPPA) from isopropyl amine (IPA). This work introduces a comparative analysis between open and tight membrane extraction (ME) systems, with and without the ionic liquid (IL) [P6,6,6,14][N(Tf)2]. The results reveal that PDMS creates a uniform and dense coating, particularly on PTFE and PVDF supports, while silica nanoparticle coatings were less stable, retaining only 50 % of nanoparticles after ME testing. A PDMS-coated PTFE membrane achieved significantly higher solute fluxes of 1.12 ± 0.01, 1.66 ± 0.02, and 0.36 ± 0.08 g/(m2h) for MBA, MPPA, and IPA, respectively, compared to an IL-wetted PTFE membrane, which was found to have fluxes of 0.60 ± 0.06, 1.01 ± 0.04, and 0.33 ± 0.10 g/(m2h) for the same solutes. A reduction in the pore size of the PTFE support further increased the fluxes to 1.74 ± 0.28, 2.75 ± 0.25, and 0.45 ± 0.08 g/(m2h) for MBA, MPPA, and IPA, respectively, achieving selectivity values of 3.83 ± 0.65 for MBA/IPA and 6.24 ± 0.88 for MPPA/IPA. Although IL impregnation marginally improved selectivity, it caused a significant reduction in solute fluxes. The PDMS coating retained 92.1 % of its mass after 24 h, while the IL retained 87.2 % over the same period. Compared to the tested IL, which presents safety concerns due to its flammability and corrosiveness, PDMS coatings provide a safer and more environmentally friendly alternative, as PDMS is non-toxic and does not bioaccumulate. These findings underscore the superior performance and environmental benefits of novel PDMS-coated membranes in tight ME setups compared to IL-based open ME systems.
2025-03-17ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Catalytic Reductive Amination and Tandem Amination–Alkylation of Esters Enabled by a Cationic Iridium Complex
Article
作者: Ruan, Zhong‐Lei ; Lu, Guang‐Sheng ; Ye, Jian‐Liang ; Lü, Jin‐Fang ; Wang, Yan ; Huang, Pei‐Qiang
Abstract:
Reported herein is a convenient and efficient method for one‐pot, catalytic reductive amination, as well as the first multi‐component tandem reductive amination—functionalization of bench‐stable and readily available common carboxylic esters. This method is based on the cationic [Ir(COD)2]BArF‐catalyzed chemoselective hydrosilylation of esters, followed by one‐pot acid‐mediated amination and nucleophilic addition. The reaction was conducted under mild conditions at a very low catalyst loading (0.1 mol % of Ir), which could be further reduced to 0.001 mol %, as demonstrated by a reaction at a 15 g scale. The method is highly versatile, allowing the use of esters with or without α‐protons for the N‐mono‐alkylation of primary and secondary amines to produce diverse secondary and tertiary amines, as well as α‐branched/functionalized amines. The method is highly chemoselective and tolerates a variety of functional groups such as bromo, trifluoromethyl, ester, and cyano groups. The value of the method was demonstrated by the one‐step catalytic synthesis of two bio‐relevant N‐mono‐methyl α‐amino esters and the antiparkinsonian agent piribedil, as well as by the use of two shorter chain triglycerides as alkylating feedstock.
25
项与 Mirodenafil dihydrochloride 相关的新闻（医药）2024-12-31
2024-12-27
临床2期临床3期申请上市临床成功
100 项与 Mirodenafil dihydrochloride 相关的药物交易
登录后查看更多信息
研发状态
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 阿尔茨海默症 | 临床3期 | 美国 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 中国 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 捷克 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 丹麦 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 法国 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 德国 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 意大利 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 荷兰 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 波兰 | 2022-12-23 | |
| 阿尔茨海默症 | 临床3期 | 西班牙 | 2022-12-23 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 210 | 廠艱繭顧構顧壓遞製糧(鹽鹹餘顧鹹憲廠製鹽遞) = 憲壓糧繭膚築醖積齋積 繭醖網糧鏇鹹選壓獵構 (觸構夢製衊淵積艱遞網 ) | 积极 | 2021-11-04 | |||
襯廠鑰簾壓網廠積築憲(餘憲淵衊糧簾蓋範壓構) = 鹹醖餘鹹衊餘選壓齋壓 觸積選艱夢範醖鹽襯網 (糧願憲餘選繭廠夢網夢 ) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用