硫酸镁/葡萄糖(Magnesium Sulfate Hydrate/Glucose) - 在研适应症：子痫，早产_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Magnesium Sulfate Hydrate・Glucose、Magsent、マグセント

靶点-

作用方式-

作用机制-

治疗领域

心血管疾病泌尿生殖系统疾病

在研适应症

子痫早产

非在研适应症-

原研机构

ASKA Pharmaceutical Co., Ltd.

在研机构

TOA Pharmaceuticals Co., Ltd.

ASKA Pharmaceutical Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2006-01-23),

早产

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C6H14O7

InChIKeyOSNSWKAZFASRNG-UHFFFAOYSA-N

CAS号1258214-35-5

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Sequence Code 67268

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关联

6

项与硫酸镁/葡萄糖相关的临床试验

CTRI/2024/07/071588

/ Not yet recruitingN/AIIT

Nebulised magnesium sulphate v/s nebulised 2 percent lignocaine for attenuation of hemodynamic stress response to laryngoscopy and tracheal intubation: A prospective randomised double blinded ,comparative study - Nil

开始日期2024-08-30

申办/合作机构-

NCT04497766

/ Completed临床4期IIT

Comparasion of Efficacy of Nebulized Magnesium Sulphate With Intravenous Magnesium Sulphate in Children With Acute Asthma

The purpose of study is to assess the effectiveness of nebulized magnesium sulphate in children presenting with acute asthma.Study perfoma consists of demographic variables,exclusion criteria and pediatric asthma score that includes respiratory rate,SPO2 at room air(requirement of oxygen),auscultatory findings in chest,dysnea and retractions.

开始日期2019-10-01

申办/合作机构

King Edward Medical University

[+1]

NCT04328636

/ Completed临床1/2期IIT

Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of The Newborn

The aim of this pilot randomized controlled blinded study is to evaluate the feasibility of using nebulized magnesium sulfate in the treatment of PPHN.

开始日期2017-11-01

申办/合作机构

Sohag University

100 项与硫酸镁/葡萄糖相关的临床结果

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100 项与硫酸镁/葡萄糖相关的转化医学

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100 项与硫酸镁/葡萄糖相关的专利（医药）

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7

项与硫酸镁/葡萄糖相关的文献（医药）

2022-09-01·Biological and Pharmaceutical Bulletin

Classification of Skin Injury Risk Caused by Extravasation of Electrolyte Solutions or Infusions in a Rat Model

Article

作者: Shibata, Yuuka ; Uno, Hiromi ; Yokooji, Tomoharu ; Matsuo, Hiroaki ; Hide, Michihiro ; Tanaka, Maiko ; Taogoshi, Takanori

Cytotoxic agents are classified according to the severity of skin injury after extravasation. However, injuries caused by extravasation of noncytotoxic agents have not been sufficiently investigated, although the risk of extravasation is mentioned in medical safety information published by the Japan Council for Quality Health Care. Therefore, in this study, we focused on noncytotoxic electrolyte solutions and infusions and evaluated skin injuries during leakage using extravasation model rats. Rats were anesthetized and intradermally injected with 100 µL of an electrolyte solution or infusion. Injection lesions were macroscopically and histopathologically evaluated for extravasation injuries. Each electrolyte solution and infusion were classified into three categories (vesicants, irritants, and non-tissue-damaging agents) depending on the degree of skin injury. Similar to saline, 0.3% potassium chloride and 0.6% magnesium sulfate showed almost no injury, and 3% sodium chloride and BFLUID^® caused erythema and induration. Erythema, induration, and ulceration were observed with the following: 10% sodium chloride, 2% calcium chloride, 8.5% calcium gluconate, 12.3% magnesium sulfate, MAGSENT^®, FESIN^®, and Intralipos^®. The duration of damage with these agents was markedly prolonged. Electrolyte solutions and infusions can be classified into vesicants (10% sodium chloride, 2% calcium chloride, 8.5% calcium gluconate, 12.3% magnesium sulfate, MAGSENT^®, FESIN^®, and Intralipos^®), irritants (3% sodium chloride and BFLUID^®), and non-tissue-damaging agents (0.3% potassium chloride and 0.6% magnesium sulfate) according to their composition. The characteristic symptoms and severity of each drug extravasation revealed in this study will provide basic information for preparation of guidelines for treatment of extravasation.

2021-08-01·Indian Journal of Pediatrics4区 · 医学

Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of Newborn: A Pilot Randomized Controlled Trial

4区 · 医学

Article

作者: Aboelez, Moustafa O ; Mahmoud, Shaimaa M ; Abdelkreem, Elsayed ; Abd El Aal, Mohamed

OBJECTIVESTo investigate the effectiveness of nebulized magnesium sulfate in treating persistent pulmonary hypertension of newborn (PPHN).METHODSTwenty-eight mechanically ventilated term neonates with severe PPHN were randomized into two groups: NebMag group (n = 14), who receiving nebulized isotonic magnesium (1024 mg/h), and IVMag group (n = 14), who received intravenous magnesium (200 mg/kg over 30 min, followed by 50 mg/kg/h). The study time frame was 24 h. Outcome measures were the changes in oxygenation index (OI), mean arterial blood pressure (MABP), vasoactive inotropic score (VIS), and serum magnesium level.RESULTSBaseline demographic, ventilatory, and hemodynamic characteristics were comparable between the two groups. At the end of the study, the OI decreased by 44.3% in the NebMag group compared with 35.3% in the IVMag group (mean difference -3.14; 95%CI -5.08, -1.19; p 0.003). The NebMag group had a higher MABP (mean difference 2.29 mmHg; 95% CI 1.80, 2.77; p 0.000) and lower VIS (mean difference -14.64; 95% CI -16.52, -12.77; p 0.000) at the 24-h study time point. The increase in serum magnesium level, measured at 12-h study time point, was lower in the NebMag group (mean difference -2.26 mmol/L; 95% CI -2.58, -1.96; p 0.000).CONCLUSIONNebulized magnesium sulfate may be an effective therapeutic modality for neonates with severe PPHN on mechanical ventilation, but this should be confirmed by larger studies. Retrospectively registered at www.clinicaltrials.gov (identifier: NCT04328636).

2015-06-20·Science and Technology of Advanced Materials3区 · 材料科学

Physico-chemical properties of biodiesel manufactured from waste frying oil using domestic adsorbents

3区 · 材料科学

ArticleOA

作者: Ismail, Samir Abd-Elmonem A ; Ali, Rehab Farouk M

We have evaluated the efficiency of sugar cane bagasse ash (SCBA), date palm seed carbon (DPSC), and rice husk ash (RHA) as natural adsorbents and compared them with the synthetic adsorbent Magnesol XL for improving the quality of waste frying oil (WFO) and for the impact on the physicochemical properties of the obtained biodiesel. We measured moisture content, refractive index (RI), density, acid value (AV), iodine value (IV), peroxide value (PV), and saponification value (SV), as well as fatty acid profile. Purification treatments with various levels of adsorbents caused significant (P ≤ 0.05) decreases in free fatty acids (FFAs), PVs, and IVs. The highest yields (86.45 and 87.80%) were observed for biodiesel samples produced from WFO treated with 2% Magnesol and 3% of RHA, respectively, followed by samples treated with 2 and 3% of DPSC or RHA. Pre-treatments caused a significant decrease in the content of C 18:2 linoleic acids, consistent with a significant increase in the content of monounsaturated and saturated fatty acids (MUFA) in the treated samples. The highest oxidation value (COX) (1.30) was observed for biodiesel samples produced from WFO without purification treatments. However, the lowest values (0.44-0.73) were observed for biodiesel samples produced from WFO treated with different levels of adsorbents. Our results indicate that pre-treatments with different levels of adsorbents regenerated the quality of WFO and improved the quality of the obtained biodiesel.

100 项与硫酸镁/葡萄糖相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
子痫	日本	ASKA Pharmaceutical Co., Ltd.	2013-03-25
子痫	日本	TOA Pharmaceuticals Co., Ltd.	2013-03-25
早产	日本	ASKA Pharmaceutical Co., Ltd.	2006-01-23

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04328636 (Pubmed \| Indian J Pediatr)	临床1/2期	新生儿持续肺动脉高压	28	Nebulized Magnesium Sulfate	鑰製選網蓋構範齋鹽鏇(廠鬱簾鏇壓壓襯願構淵) = 構網範獵壓壓襯遞艱廠壓廠顧淵願鏇積繭鏇築 (積遞膚製壓願襯齋製淵 )	-	2021-01-08
				IV Magnesium	顧衊範餘艱觸膚憲糧範(簾蓋鬱鑰獵淵醖鹹繭淵) = 鏇築膚遞夢繭蓋壓鑰範願夢鬱襯壓範憲構鬱襯 (觸醖醖壓憲鑰簾選夢膚 )
NCT01515995 (CTgov)	临床4期	哮喘	50	Nebulized magnesium sulfate (Magnesium Sulfate Group)	衊餘艱鹽憲積鹹選襯鬱(蓋鏇糧淵鑰製淵憲鬱蓋) = 壓選築鹹顧鏇選範壓範鏇廠繭廠願簾壓願膚鹽 (構顧築齋積繭築餘鏇淵, 觸壓壓範衊鏇鏇選餘醖 ~ 膚鹹鹽網蓋選醖夢繭選) 更多	-	2019-02-21
				Nebulized magnesium sulfate (Normal Saline Group)	衊餘艱鹽憲積鹹選襯鬱(蓋鏇糧淵鑰製淵憲鬱蓋) = 襯積範選餘獵窪壓製壓鏇廠繭廠願簾壓願膚鹽 (構顧築齋積繭築餘鏇淵, 膚築窪醖蓋糧淵獵構鬱 ~ 壓壓範鹽選襯餘網構艱) 更多
Pubmed \| J Emerg Med	N/A	哮喘	-	Nebulized magnesium sulfate plus albuterol	(齋顧選醖夢鏇鑰網繭蓋) = 醖鬱鑰顧齋淵壓積鬱簾醖淵構衊餘壓顧繭構築 (鏇醖蓋廠範積衊觸廠願 )	积极	2004-07-01
				Nebulized albuterol plus saline	(齋顧選醖夢鏇鑰網繭蓋) = 艱範遞獵壓築蓋鹽鏇衊醖淵構衊餘壓顧繭構築 (鏇醖蓋廠範積衊觸廠願 )