Nebulised magnesium sulphate v/s nebulised 2 percent lignocaine for attenuation of hemodynamic stress response to laryngoscopy and tracheal intubation: A prospective randomised double blinded ,comparative study - Nil

开始日期2024-08-30

申办/合作机构-

NCT04497766 / Completed临床4期IIT

Comparasion of Efficacy of Nebulized Magnesium Sulphate With Intravenous Magnesium Sulphate in Children With Acute Asthma

The purpose of study is to assess the effectiveness of nebulized magnesium sulphate in children presenting with acute asthma.Study perfoma consists of demographic variables,exclusion criteria and pediatric asthma score that includes respiratory rate,SPO2 at room air(requirement of oxygen),auscultatory findings in chest,dysnea and retractions.

开始日期2019-10-01

申办/合作机构

King Edward Medical University

[+1]

NCT04328636 / Completed临床1/2期IIT

Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of The Newborn

The aim of this pilot randomized controlled blinded study is to evaluate the feasibility of using nebulized magnesium sulfate in the treatment of PPHN.

开始日期2017-11-01

申办/合作机构

Sohag University

100 项与硫酸镁/葡萄糖相关的临床结果

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100 项与硫酸镁/葡萄糖相关的转化医学

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100 项与硫酸镁/葡萄糖相关的专利（医药）

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项与硫酸镁/葡萄糖相关的文献（医药）

2022-09-01·Biological and Pharmaceutical Bulletin

Classification of Skin Injury Risk Caused by Extravasation of Electrolyte Solutions or Infusions in a Rat Model

Article

作者: Shibata, Yuuka ; Uno, Hiromi ; Yokooji, Tomoharu ; Matsuo, Hiroaki ; Hide, Michihiro ; Tanaka, Maiko ; Taogoshi, Takanori

Cytotoxic agents are classified according to the severity of skin injury after extravasation. However, injuries caused by extravasation of noncytotoxic agents have not been sufficiently investigated, although the risk of extravasation is mentioned in medical safety information published by the Japan Council for Quality Health Care. Therefore, in this study, we focused on noncytotoxic electrolyte solutions and infusions and evaluated skin injuries during leakage using extravasation model rats. Rats were anesthetized and intradermally injected with 100 µL of an electrolyte solution or infusion. Injection lesions were macroscopically and histopathologically evaluated for extravasation injuries. Each electrolyte solution and infusion were classified into three categories (vesicants, irritants, and non-tissue-damaging agents) depending on the degree of skin injury. Similar to saline, 0.3% potassium chloride and 0.6% magnesium sulfate showed almost no injury, and 3% sodium chloride and BFLUID^® caused erythema and induration. Erythema, induration, and ulceration were observed with the following: 10% sodium chloride, 2% calcium chloride, 8.5% calcium gluconate, 12.3% magnesium sulfate, MAGSENT^®, FESIN^®, and Intralipos^®. The duration of damage with these agents was markedly prolonged. Electrolyte solutions and infusions can be classified into vesicants (10% sodium chloride, 2% calcium chloride, 8.5% calcium gluconate, 12.3% magnesium sulfate, MAGSENT^®, FESIN^®, and Intralipos^®), irritants (3% sodium chloride and BFLUID^®), and non-tissue-damaging agents (0.3% potassium chloride and 0.6% magnesium sulfate) according to their composition. The characteristic symptoms and severity of each drug extravasation revealed in this study will provide basic information for preparation of guidelines for treatment of extravasation.

100 项与硫酸镁/葡萄糖相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
子痫	日本	ASKA Pharmaceutical Co., Ltd.	2013-03-25
子痫	日本	TOA Pharmaceuticals Co., Ltd.	2013-03-25
早产	日本	ASKA Pharmaceutical Co., Ltd.	2006-01-23

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01515995 (CTgov)	临床4期	哮喘	50	Nebulized magnesium sulfate (Magnesium Sulfate Group)	鹽糧壓鑰醖膚糧觸積鑰(繭餘夢構繭鏇廠淵廠鬱) = 鑰繭願願願壓願憲膚選醖觸醖醖鹹鏇齋繭廠淵 (糧獵獵廠蓋鹹顧鹽艱鏇, 壓廠積齋鹽鹹鹽廠夢獵 ~ 膚醖顧鏇醖淵願鬱積蓋) 更多	-	2019-02-21
				Nebulized magnesium sulfate (Normal Saline Group)	鹽糧壓鑰醖膚糧觸積鑰(繭餘夢構繭鏇廠淵廠鬱) = 積網積鹹選鏇製窪顧鹹醖觸醖醖鹹鏇齋繭廠淵 (糧獵獵廠蓋鹹顧鹽艱鏇, 範鬱鹹積構淵齋製糧構 ~ 遞淵範鑰壓夢範選繭壓) 更多
Pubmed \| J Emerg Med	N/A	哮喘	-	Nebulized magnesium sulfate plus albuterol	(夢繭觸築糧鏇網築憲夢) = 廠醖廠願鏇觸築壓壓膚窪鏇獵繭醖糧繭製願顧 (餘醖淵醖鹽醖鏇願願鬱 )	积极	2004-07-01
				Nebulized albuterol plus saline	(夢繭觸築糧鏇網築憲夢) = 鑰鏇餘蓋夢廠願觸膚蓋窪鏇獵繭醖糧繭製願顧 (餘醖淵醖鹽醖鏇願願鬱 )