盐酸芬太尼(Fentanyl Hydrochloride) - 药物靶点：δ opioid receptor x κ opioid receptor x μ opioid receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Fentanyl hydrochloride (JAN)、Ionsys

靶点

δ opioid receptor x κ opioid receptor x μ opioid receptor

作用机制

δ opioid receptor激动剂(δ-阿片受体激动剂)、κ opioid receptor激动剂(κ-阿片受体激动剂)、μ opioid receptor激动剂(μ-阿片受体激动剂)

治疗领域

神经系统疾病

在研适应症-

非在研适应症

术后疼痛

原研机构

The Medicines Company (Spain) SL

在研机构-

非在研机构

Incline Therapeutics Europe Ltd.Janssen-Cilag International NV

The Medicines Co.

最高研发阶段撤市

首次获批日期

欧盟 (2006-01-24),

术后疼痛

最高研发阶段(中国)-

特殊审评-

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结构

分子式C22H29ClN2O

InChIKeyLHCBOXPPRUIAQT-UHFFFAOYSA-N

CAS号1443-54-5

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关联

4

项与盐酸芬太尼相关的临床试验

ChiCTR2400081101 / Suspended临床4期IIT

Effects of remimazolam combined with afentanyl hydrochloride on hemodynamics during anesthesia induction in children with congenital heart disease

开始日期2024-03-01

申办/合作机构

上海儿童医学中心

NCT04679818 / Completed临床3期IIT

Postoperative Consequences of Intraoperative NOL Titration

To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.

开始日期2020-12-30

申办/合作机构

The Cleveland Clinic Foundation

NCT02784340 / Completed临床4期IIT

Comparison of Local and Intra Venous Dexamethasone on Post Operative Pain and Recovery After Caeseream Section

A Prospective, randomized study conducted on 120 pregnant women attending the labour wards in Kasr Al Ainy and Fayoum maternity hospitals from May 2014 to December 2015. All participants were scheduled for elective cesarean section under spinal anaesthesia and were randomly divided into 3 equal groups. Group 1(40 women) received 16 mg Dexamethasone IV drip. Group II (40 women) received 16 mg Dexamethasone subcutaneous injection around the caesarean section scar after skin closure and Group III received Placebo in the form of IV fluids 500 cc saline infusion. All cases were followed up for 48 hours for assessment of level of pain by using a 10-cm visual analog scale (VAS). Primary outcome parameters were VAS score and the need for additional analgesics. Other parameters were hemodynamic changes and occurrence of side effects or complications

开始日期2014-05-01

申办/合作机构

Cairo University

100 项与盐酸芬太尼相关的临床结果

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100 项与盐酸芬太尼相关的转化医学

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100 项与盐酸芬太尼相关的专利（医药）

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39

项与盐酸芬太尼相关的文献（医药）

2024-08-02·Journal of Occupational and Environmental Hygiene

Assessment of glove stretch and storage temperature on fentanyl permeation: Implications for standard test methods and PPE recommendations

Article

作者: Keyes, Patrick H ; Yoon, N Katherine ; Soo, Jhy-Charm ; Greenawald, Lee Ann ; Streeter, Rebecca T ; Fisher, Edward M ; Hofacre, Kent C

The National Institute for Occupational Safety and Health recommends the use of nitrile gloves with a minimum thickness of 5.0 ± 2.0 mil [0.127 ± 0.051 millimeters] in situations where it is suspected or known that fentanyl or other illicit drugs are present. However, there is limited data available on fentanyl permeation through gloves. Current test methods used to measure fentanyl permeation do not consider the effect of glove fit and flexion. Furthermore, first responders need to have PPE readily available in the field, and storage conditions may affect the protective performance of the gloves. The objective of this study was to evaluate the effects of glove stretch and storage temperatures on glove durability and barrier performance against fentanyl. Nine nitrile glove models previously shown to be resistant to fentanyl permeation were selected for this investigation. These nine models were stretched 25% in one linear direction, to consider glove fit and flexion, and tested against fentanyl hydrochloride permeation. Additionally, four of the nine glove models were stored at 48 °C, 22 °C, and -20 °C, and evaluated for tensile strength, ultimate elongation, and puncture resistance after up to 16 wk of storage and fentanyl permeation after up to 8 wk of storage. At least one sample for six of the nine tested models had maximum permeation over the test method fail threshold when stretched. The tested storage temperatures showed no effect on glove tensile strength, ultimate elongation, and puncture resistance. The findings of this study can be used to inform PPE recommendations, with consideration to storage practices and proper sizing for first responders with potential exposure to fentanyl and other illicit drugs. The results of this study can be used to assess the need for new standard test methods to evaluate the barrier performance of gloves and shelf-life determination with consideration to glove fit.

2022-09-01·Journal of Forensic Sciences

Characterization of fentanyl HCl powder prior to and after systematic degradation

Article

作者: Simon, Alison G. ; Wagner, Jarrad R. ; Ciesielski, Austin L. ; Welch, Katie

AbstractFentanyl HCl is of particular interest in forensic cases but there is a notable gap in literature regarding its analysis. This study utilized a multi‐method approach to characterize fentanyl HCl powder, both fresh and following a forced degradation process. Using sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) and direct injection gas chromatography–mass spectrometry (GC–MS), five compounds were identified in fresh fentanyl HCl powder. The identified compounds were: N‐phenylpropanamide, 1‐phenethyl‐4‐propionyloxypiperidine (1‐P‐4‐POP), 4‐anilino‐N‐phenethylpiperidine (4‐ANPP), acetylfentanyl, and fentanyl; all identified compounds but acetylfentanyl and fentanyl decreased in quantity as the sample was degraded. Fresh headspace samples analyzed with solid phase microextraction (SPME)‐GC–MS identified four compounds in common with the powder analyses: N‐phenylpropanamide,1‐P‐4‐POP, 4‐ANPP, and fentanyl. Acetylfentanyl was not present in the headspace samples, although two additional compounds were: N‐phenylacetamide and N‐phenethyl‐4‐piperidinone (NPP). Where direct analysis of degraded fentanyl HCl showed decreased quantities of the identified compounds, headspace samples of the degraded fentanyl HCl resulted in higher quantities, implying that the degradation process drove those compounds to volatilize. Notably, fentanyl was identified in the headspace, implying that this could be an appropriate target for standoff detection. Finally, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) confirmed that the forced degradation process had little permanent effect on the powder.

2022-01-24·American Journal of Epidemiology2区 · 医学

Time-Series Analysis of Fentanyl Concentration in the Unregulated Opioid Drug Supply in a Canadian Setting

2区 · 医学

Article

作者: Richard Laing ; Jane Buxton ; Kenneth W Tupper ; Mark Lysyshyn ; Lianping Ti ; Cameron J Grant ; Evan Wood ; Samuel Tobias ; Jaime Arredondo

AbstractNorth America has been contending with an unregulated street drug supply in which opioids are often adulterated with illicitly manufactured fentanyl. The unpredictability of composition may result in an increased risk of overdose due to unexpected elevated concentrations of the high-potency drug. Using data from a community-based drug-checking project, we evaluated trends in fentanyl concentration of illicit opioids in the context of an overdose epidemic. Using a quantification model for fentanyl hydrochloride, historical Fourier-transform infrared spectra from opioid drug-checking samples were analyzed to determine fentanyl concentrations. Median monthly fentanyl concentrations were plotted, and polynomial and autoregressive time-series analyses were performed to examine trends over time. A total of 3,621 fentanyl-positive samples were included in the study, spanning November 2017 to December 2019. Monthly median fentanyl concentrations ranged from 4.5% to 10.4%. Time-series analyses indicated that a third-degree polynomial model fit the data well (R2 = 0.639), suggesting a cyclical pattern in median concentration over time. Notably, absolute variance in fentanyl concentration decreased by an average 0.1% per month (P < 0.001). Future research should explore the relationship between fentanyl concentration and overdose to identify potential targeted harm-reduction interventions that can respond to changes in observed fentanyl concentration.

100 项与盐酸芬太尼相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10811	盐酸芬太尼	N02AB03 N01AH01	DB00813

研发状态

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04679818 (CTgov)	临床3期	麻醉 \| 药物不良反应	72	PMD-200 Nol-guided opioid administration (PMD-200 NOL Group)	鑰顧蓋築築憲構獵衊襯(餘繭觸積艱窪構願構遞) = 夢醖構壓醖遞醖壓淵遞鬱積網窪鬱餘鬱鹽壓鹽 (遞鹹襯鏇襯壓壓顧構淵, 顧製觸齋鬱製繭廠壓艱 ~ 鹽鹽衊襯鬱積鹽願獵憲) 更多	-	2024-06-21
				Routine opioid management (Control Group)	鑰顧蓋築築憲構獵衊襯(餘繭觸積艱窪構願構遞) = 衊築鹽網夢鬱膚憲觸鹽鬱積網窪鬱餘鬱鹽壓鹽 (遞鹹襯鏇襯壓壓顧構淵, 壓窪膚齋網壓齋衊憲簾 ~ 範範膚範築築繭廠壓鹽) 更多