Indonesia is one of country that contributes the most cases of tuberculosis worldwide. Tuberculosis is the most commonly etiology of exudative pleural effusion. There have been many studies about undiagnosed exudative pleural effusions, but there are not many studies about the use of medical thoracoscopy for diagnosing transudative and exudative pleural effusion, especially on biomarkers of C-Reactive Protein (CRP), D-dimer, Adenosine Deaminase (ADA), Antinuclear Antibody (ANA), C3 C4 complements, Cancer Antigen 125 (CA-125), Xpert Mycobacterium Tuberculosis (Xpert MTB), Lupus Erythematosus cell (LE cell), cytology (effusion and smear) and histopathology. Information gained from those biomarkers via thoracocentesis and medical thoracoscopy, etiology of exudative and transudative pleural effusion can be detected earlier and clearly, especially etiology of infection, autoimmune, and malignancy that further can be used to reduce patients' hospitalization period, mortality, and to develop the new therapeutic agents.

开始日期2022-11-01

申办/合作机构

University of Indonesia

[+1]

NCT04679818 / Completed临床3期IIT

Postoperative Consequences of Intraoperative NOL Titration

To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.

开始日期2020-12-30

申办/合作机构

The Cleveland Clinic Foundation

100 项与盐酸芬太尼相关的临床结果

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100 项与盐酸芬太尼相关的转化医学

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100 项与盐酸芬太尼相关的专利（医药）

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项与盐酸芬太尼相关的文献（医药）

2025-03-01·TALANTA

Femtosecond laser-induced Au nanostructure-decorated with plasmonic nanomaterials for sensitive SERS-based detection of fentanyl

Article

作者: Liu, Keng-Ku ; Chen, Chien-Hung ; Hsu, Yun-Tzu ; Hsu, Ju-Yin ; Chen, Hung-Wen

Fentanyl and its analogs have emerged as the main factor behind the ongoing opioid abuse globally in recent years. However, the existing techniques for sensitive and accurate detection of fentanyl are often complex, laborious, expensive, and restricted to central healthcare facilities. We reported herein a plasmonic biochip fabricated by the femtosecond laser-induced nanostructures and plasmonic nanomaterials for sensitive SERS-based detection of fentanyl. Yolk-shell structured plasmonic nanomaterials are employed owing to their unique optical properties. The femtosecond laser direct writing technique creates three-dimensional silicon nanostructures followed by gold deposition and the immobilization of plasmonic nanomaterials. This SERS biochip fabricated by the femtosecond laser-induced nanostructure decorated with yolk-shell structured plasmonic nanomaterials enables the rapid and sensitive detection of fentanyl with the limit of detection of 3.33 ng/mL.

2025-02-01·TALANTA

High-throughput screening of fentanyl analogs

Article

作者: Tose, Lilian Valadares ; Forero, Andrew R ; Fernandez-Lima, Francisco ; Krechmer, Jordan E ; Muntean, Felician ; Miller, Samuel A

This study presents an analytical approach coupling novel ambient ionization sources with trapped ion mobility spectrometry (TIMS) and tandem mass spectrometry (MS/MS) for the rapid characterization of fentanyl analogs. Two ambient ionization sources were illustrated for minimal sample preparation and rapid analysis: electrospray ionization (nESI) and direct analysis in real time (DART). Fentanyl analogs can be separated using nESI-TIMS-MS/MS based on differences in their mobility and/or fragmentation pattern; reference mobility spectra are reported for 234 single standards. In contrast, DART-TIMS-MS/MS allowed for the characterization of 201 compounds due to differences in the protonation pattern and efficiency when compared to nESI. The TIMS high resolving power (R > 80) allowed baseline separation for most isomers and mobility trends were established for methylated and fluorinated isomers, with the more compact ortho-substituted analogs showing distinct separation from para- and meta-substituted species. This multi-dimensional strategy offers a comprehensive characterization of fentanyl analogs and other synthetic opioids with minimal sample preparation. This analysis shows significant potential for high-throughput screening (<5 min) and high sensitivity detection (

2024-11-01·ANNALS OF EMERGENCY MEDICINE

Frequency of Fentanyl Exposure in Emergency Department Patients With Illicit Drug Use

Article

作者: Chang, Bernard P ; Martins, Silvia S ; Comer, Sandra D ; Sacco, Dana L ; Probst, Marc A ; Mannes, Zachary L

STUDY OBJECTIVE:

Addition of illicitly manufactured fentanyl to the opioid and nonopioid illicit drug supply has exacerbated the drug overdose crisis in the United States. People who use drugs are often unaware that their drugs contain fentanyl. Awareness about fentanyl adulteration may be protective against fatal overdose.

METHODS:

We performed a cross-sectional study of a convenience sample of emergency department (ED) patients who presented with illicit drug-related complaints from April 2022 to January 2024 in New York City, NY. Patients were surveyed about their drug use and provided urine samples for fentanyl testing. Results were analyzed according to the patient's intention of using opioids versus only nonopioid substances.

RESULTS:

Of 338 eligible patients, we enrolled 229 (68% acceptance, men: 78%, mean age: 43 years [SD=12.2], Hispanic/Latino: 57%), with 53% (121/229) and 47% (108/229) intending to use opioids and only nonopioid substances, respectively. Among patients who used opioids and provided urine, 89% (86/97) samples were positive for fentanyl, including 90% (27/30) fentanyl positivity among those who did not believe that they were using fentanyl. Among those intending to use only nonopioids, 24% (23/94) urine samples were positive for fentanyl.

CONCLUSIONS:

Many drug-related ED visits involved fentanyl exposure, even when individuals did not believe they were using fentanyl. Knowledge of fentanyl adulteration can inform people who intend to use opioid and/or nonopioid drugs about harm reduction approaches, such as distribution of fentanyl test strips and educational interventions.

100 项与盐酸芬太尼相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D10811	盐酸芬太尼	N02AB03 N01AH01	DB00813

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
术后疼痛	欧盟	Janssen-Cilag International NV	2006-01-24
术后疼痛	冰岛	Janssen-Cilag International NV	2006-01-24
术后疼痛	列支敦士登	Janssen-Cilag International NV	2006-01-24
术后疼痛	挪威	Janssen-Cilag International NV	2006-01-24

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临床结果

适应症

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04679818 (CTgov)	临床3期	麻醉 \| 药物不良反应	72	PMD-200 Nol-guided opioid administration (PMD-200 NOL Group)	窪壓鏇鹽醖衊醖窪網廠(網夢積艱簾獵構廠艱膚) = 衊襯獵觸鏇遞蓋鬱鑰簾觸窪繭憲鏇壓廠鑰壓遞 (觸餘選獵遞鏇顧襯願積, 製壓衊鹹範淵簾餘憲願 ~ 鏇遞製築襯簾憲遞網廠) 更多	-	2024-06-21
NCT04679818 (CTgov)	临床3期	麻醉 \| 药物不良反应	72	Routine opioid management (Control Group)	窪壓鏇鹽醖衊醖窪網廠(網夢積艱簾獵構廠艱膚) = 鏇餘窪衊選齋觸願糧糧觸窪繭憲鏇壓廠鑰壓遞 (觸餘選獵遞鏇顧襯願積, 遞觸觸廠獵壓蓋醖襯構 ~ 網夢觸艱鏇艱壓遞糧顧) 更多	-	2024-06-21
Pubmed \| Curr Med Res Opin	N/A	-	-	Fentanyl sublingual spray (100-800 mcg)	鑰齋鹹淵鏇鬱膚繭淵構(範淵製遞襯鑰顧夢鹽鏇) = 蓋壓餘艱願齋選遞鏇網簾壓鬱鑰範願窪網襯鑰 (醖鹹艱艱製鹽簾願糧醖 )	-	2017-11-02