Zirconium (89Zr) crefmirlimab berdoxam

This ground-breaking collaboration will enhance accuracy and efficiency of immunotherapy response for improved patient outcomes LOS ANGELES and VALENCIA, Spain, May 2, 2023 /PRNewswire/ -- ImaginAb Inc., a global biotechnology company developing 89Zr crefmirlimab berdoxam (CD8 ImmunoPET™) imaging agent and radiopharmaceutical therapies (RPT), and Quibim, a global company born with the ambition of transforming imaging data into actionable predictions, are pleased to announce their new collaboration. Together, the two partners aim to revolutionize immunotherapy treatment planning by combining ImaginAb's investigational CD8 ImmunoPET technology with Quibim's cutting-edge image processing technology. Immunotherapy has shown remarkable promise in treating cancer and other diseases, but accurately predicting the efficacy of these treatments remains a challenge. CD8 ImmunoPET™ is an 89Zr-labeled minibody that has been designed to bind to the CD8 receptor on human T cells for quantitative, non-invasive PET imaging. This method is currently being researched to determine whether it may be used to assess the immune status of a patient, to measure the efficacy of immunotherapies, and to predict patient outcomes. As part of this collaboration, Quibim will develop an imaging-based algorithm to interpret CD8 ImmunoPET™ PET/CT exams, with the aim of quantitatively assessing the efficacy of the 89Zr-labeled minibody in targeting the CD8 receptor in the tumor microenvironment. The algorithm will use advanced image processing techniques to extract quantitative measures of tracer uptake in the tumor and surrounding tissues, enabling accurate assessment of the binding efficacy of the minibody to CD8 receptors. The resulting quantitative data will provide valuable insights into the minibody's biodistribution and targeting specificity to inform future clinical development of the imaging agent and its potential therapeutic application. Ian Wilson, Chief Executive Officer of ImaginAb, said: "This partnership presents a unique opportunity to broaden the potential applicability of CD8 ImmunoPET by incorporating advanced image processing techniques into image interpretation. We look forward to working together with Quibim to deepen our understanding of immune imaging with the aim of ultimately improving patient care." Dr. Ángel Alberich, CEO of Quibim, said: "We are thrilled to partner with ImaginAb in this ground-breaking effort to advance in the quantitative assessment of novel radiotracers' efficacy in PET/CT exams. Together, we aim to make a real difference in the lives of patients by improving the accuracy and efficiency of immunotherapy prediction through imaging-based models." Through this collaboration, ImaginAb and Quibim are poised to make significant contributions to the field of immunotherapy with the goal of improving the lives of countless patients. Stay tuned for updates on our progress and breakthroughs. About ImaginAb A clinical stage, revenue-generating global biotechnology company developing next-generation imaging agents and radiopharmaceutical therapy products through its proprietary minibody and cys-diabody platforms. The lead candidate, CD8 ImmunoPET™, is currently in Phase II clinical trials and has been licensed by pharmaceutical and biotech companies for use in immunotherapy clinical trials. For more information, visit About Quibim Quibim, with offices in New York (United States), Cambridge (UK) and Valencia, Madrid and Barcelona (Spain), was born from the ambition of transforming imaging into a catalyst for precision health. This is done designing pioneering tools that unlock imaging data to improve patient outcomes. The company is specialized in the development of AI models created by the use of real-world evidence (RWE) projects and biopharma partners to extract new insights from images; thereby developing novel quantitative imaging biomarkers to deeply analyze disease mechanisms, advance drug development, and monitor treatment progress using a whole-body approach. Quibim leads RWE studies with 10M+ de-identified research imaging registries from 50.000+ oncology patients. For more information, visit SOURCE ImaginAb, Inc.

HOUSTON, Aug. 10, 2022 /PRNewswire/ -- UC Davis, a leading university in molecular imaging that collaborated with United Imaging to develop the world's first total-body PET/CT scanner, 'uEXPLORER®,' recently presented their research on COVID-19 at the 2022 Society of Nuclear Medicine and Molecular Imaging (SNMMI) annual meeting. Guided by the uEXPLORER scanner along with a new labeled radiotracer with high affinity to T cells (89Zr-Crefmirlimab-Berdoxam), UC Davis Project Scientist and lead author Dr. Negar Omidvari unveiled the first high-resolution PET image of total-body CD8+ T-cell distribution after COVID-19 infection. The image could shed light on the pathological mechanism and immune response to COVID-19 infection. Continue Reading The first reported image of CD8+ T cell distribution in a recovered COVID-19 patient (F, 29 y/o, BMI 29), imaged 7 weeks post symptom onset on the uEXPLORER total-body PET/CT scanner, using a ~0.5 mCi injected dose of 89Zr-Df-Crefmirlimab-Berdoxam. Lymphoid organs containing CD8+ T cells (such as spleen, bone marrow, lymph nodes, and tonsils) showed the largest uptake, reflected by the darker black parts of the image. Image courtesy of Dr. Negar Omidvari at UC Davis. Dr. Simon R. Cherry (left) and Dr. Ramsey D. Badawi (right) standing in front of the uEXPLORER scanner. Cytotoxic T cells are key players in the cell-mediated immune response against viral infections. However, 95% of T cells are in tissues rather than in the blood circulation and are therefore difficult to assess non-invasively. High sensitivity PET imaging using a specific T cell radiotracer offers a new methodology to track tissue concentrations of T cells without invasive sampling. The radiotracer used, 89Zr-Crefmirlimab-Berdoxam, is an investigational tracer provided for the study by ImaginAb who is currently in Phase IIb testing to determine predictive performance. In the reported study, patients recovering from COVID-19 infection received a low injection dose (~0.5 mCi) of 89Zr-labeled radiotracer that targeted CD8+ T cells and underwent a uEXPLORER PET/CT scan at different time points. A control group was also studied. The total-body PET images revealed subtle differences between five recovering COVID-19 patients and three healthy volunteers. The exceptional image quality obtained using the uEXPLORER scanner confirmed CD8+ T cell deposition in the spleen, liver, bone marrow, lymph nodes, and tonsils, as well as differences in the clearance rate of the radiotracer from the blood. Imaging was accomplished with minimal radiation dose to the patients. This research paves the way for further exploration of the assessment of immune response to infectious diseases and cancer, the assessment of response to vaccines in human subjects, and the fundamental mechanisms of the immune system in general. This disruptive technology co-developed by UC Davis and United Imaging was selected as one of the "2018 Breakthroughs of the Year" by Physics World. It pushes the boundaries of traditional PET scanners, with an effective sensitivity that is up to 68-fold greater than current commercial PET scanners. Combined with a 194 cm axial PET field of view, the uEXPLORER scanner can capture dynamic changes to radiotracer distribution across the entire human body with high temporal resolution, which is an essential attribute for this type of research. Simon R. Cherry, Ph.D., Distinguished Professor of Biomedical Engineering and Radiology at UC Davis, was recently awarded the Benedict Cassen Prize at the 2022 SNMMI annual meeting for his pioneering work and immense contributions to nuclear medicine instrumentation and molecular imaging. He commented: "We have now contributed to several different disease areas based on the high sensitivity and total-body coverage of the uEXPLORER scanner. This research is another demonstration of how groundbreaking imaging technology, combined with highly specific radiotracers, can open new opportunities in studying the complex interactions within the whole body, both in health and in response to disease. We hope this research will contribute to a better understanding of the immunological response to COVID-19, and serve as an example for how the immune system can be interrogated at a systems level with total-body PET." SOURCE United Imaging Healthcare Co., Ltd.