Effect of Highly Purified Menotrophin and Recombinant Follicle Stimulating (rFSH, Follitrophin Alpha) in Subfertile Female Patients Undergoing IVF on Progesterone Serum Levels During the Follicular Phase and Their Possible Use as Predictors for the Success Rate of Ongoing Pregnancies

This study is aimed to demonstrate that highly purified Menotrophin produces significant lower progesterone serum levels during the follicular phase in comparison to Follitropin alpha in the treatment of subfertile females undergoing an in vitro fertilisation (IVF) and to investigate if the progesterone serum levels might be a useful predictor for the success rate of the ongoing pregnancy rates

开始日期2010-10-01

申办/合作机构

Ferring Pharmaceuticals A/S

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100 项与 Human chorionic gonadotropin (Ferring ) 相关的临床结果

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100 项与 Human chorionic gonadotropin (Ferring ) 相关的转化医学

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100 项与 Human chorionic gonadotropin (Ferring ) 相关的专利（医药）

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项与 Human chorionic gonadotropin (Ferring ) 相关的文献（医药）

2024-06-01·Reproductive Biology

Gonadotropin upregulates intraovarian calpains-1 and −2 during ovarian follicular recruitment in the SD rat model.

Article

作者: Gupta, Rakesh Kumar ; Jha, Rajesh Kumar ; Tripathi, Rupal ; Singh, Akanksha ; Rashid, Rumaisa

Calpain role has been shown in the cumulus cell-oocyte complexes and, corpus luteum. We investigated the association of calpains-1 and -2 in ovarian folliculogenesis using the Sprague-Dawley (SD) rat model and steroidogenesis in the human granulosa cells (hGCs). We induced PCOS in 42-day-old SD rats by letrozole oral gavage for 21 days. Premature ovarian failure (POF) was induced in 21-day-old SD rats by 4-vinylcyclohexene diepoxide (VCD). Ovulation and ovarian hyperstimulatory (OHS) syndrome were induced by pregnant mare gonadotropin (PMSG) + human chorionic gonadotropin (hCG) treatments in 21 days SD rats, respectively. Steroidogenesis is stimulated in human granulosa cells (hGCs) by forskolin and the response of 17-beta-estradiol (E2) on calpains expression was checked in hGCs. The protein expression by immunoblotting and activity by biochemical assay of calpains-1 and -2 showed an oscillating pattern in the ovarian cycle. PMSG-induced follicular recruitment showed upregulation of calpains-1 and -2, but with no change during ovarian function cessation (POF). Upregulated calpain-2 expression and calpain activity was found in the hCG +PMSG-induced ovulation. Letrozole-induced PCOS showed downregulation of calpain-1, but upregulation of calpain-2. PMSG+hCG-induced OHS led to the upregulation of calpain-1. Letrozole and metformin separately increased the expression level of calpains-1 and -2 in the hGCs during luteinization. In conclusion, the expression levels of calpains -1 and -2 are increased with ovarian follicular recruitment by PMSG and calpain-1 is decreased in the PCOS condition, and letrozole and metformin upregulate the expression of calpains-1 and -2 during luteinization in the hGCs possibly via E2 action.

2024-06-01·Animal Bioscience

Improving the meiotic competence of small antral follicle-derived porcine oocytes by using dibutyryl-cAMP and melatonin

Article

作者: Jitjumnong, Jakree ; Tang, Pin-Chi

Objective: We increased the nuclear maturation rate of antral follicle derived oocytes by using a pre-in vitro maturation (IVM) culture system and improved the developmental potential of these porcine pathenotes by supplementing with melatonin. Furthermore, we investigated the expression patterns of genes involved in cumulus expansion (HAS2, PTGS2, TNFAIP6, and PTX3) derived from small and medium antral follicles before and after oocyte maturation.Methods: Only the cumulus oocyte-complexes (COCs) derived from small antral follicles were induced with [Pre-SF(+)hCG] or without [Pre-SF(-)hCG] the addition of human chorionic gonadotropin (hCG) during the last 7 h of the pre-IVM period before undergoing the regular culture system. The mature oocytes were investigated on embryonic development after parthenogenetic activation (PA). Melatonin (10-7 M) was supplemented during in vitro culture (IVC) to improve the developmental potential of these porcine pathenotes.Results: A pre-IVM culture system with hCG added during the last 7 h of the pre-IVM period [Pre-SF(+)hCG] effectively supported small antral follicle-derived oocytes and increased their nuclear maturation rate. The oocytes derived from medium antral follicles exhibited the highest nuclear maturation rate in a regular culture system. Compared with oocytes cultured in a regular culture system, those cultured in the pre-IVM culture system exhibited considerable overexpression of HAS2, PTGS2, and TNFAIP6. Porcine embryos treated with melatonin during IVC exhibited markedly improved quality and developmental competence after PA. Notably, melatonin supplementation during the IVM period can reduce and increase the levels of intracellular reactive oxygen species (ROS) and glutathione (GSH), respectively.Conclusion: Our findings indicate that the Pre-SF(+)hCG culture system increases the nuclear maturation rate of small antral follicle-derived oocytes and the expression of genes involved in cumulus expansion. Melatonin supplementation during IVC may improve the quality and increase the blastocyst formation rate of porcine embryos. In addition, it can reduce and increase the levels of ROS and GSH, respectively, in mature oocytes, thus affecting subsequent embryos.

2024-04-01·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and reproductive status dependent

Article

作者: Bhatta, Sabina ; Casadesus, Gemma ; Piontkivska, Helen ; Labrador, Luis Montero ; Suresh, Sneha ; Mey, Megan

The mechanisms that underly reproductive hormone effects on cognition, neuronal plasticity, and AD risk, particularly in relation to gonadotropin LH receptor (LHCGR) signaling, remain poorly understood. To address this gap in knowledge and clarify the impact of circulating steroid hormones on the therapeutic effects of CNS LHCGR activation, we delivered the LHCGR agonist human chorionic gonadotropin (hCG) intracerebroventricularly (ICV) and evaluated functional, structural, plasticity-related signaling cascades, Aβ pathology, and transcriptome differences in reproductively intact and ovariectomized (OVX) APP/PS1 AD female mice. Here we demonstrate that CNS hCG delivery restored function to wild-type levels only in OVX APP/PS1 mice. Spine density was increased in all hCG treated groups independently of reproductive status. Notably, increases in BDNF signaling and cognition, were selectively upregulated only in the OVX hCG-treated group. RNA sequencing analyses identified a significant increase in peripheral myeloid and pro-inflammatory genes within the hippocampi of the OVX group that were completely reversed by hCG treatment, identifying a potential mechanism underlying the selective therapeutic effect of LHCGR activation. Interestingly, in intact mice, hCG administration mimicked the effects of gonadectomy. Together, our findings indicate that CNS LHCGR agonism in the post-menopausal context is beneficial through trophic and immune mechanisms. Our findings also underscore the presence of a steroid-LHCGR mechanistic interaction that is unexplored yet potentially meaningful to fully understand "post-menopausal" brain function and CNS hormone treatment response.

100 项与 Human chorionic gonadotropin (Ferring ) 相关的药物交易

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适应症	国家/地区	公司	日期
隐睾	美国	Ferring Pharmaceuticals, Inc.	1974-01-15
性腺机能减退	美国	Ferring Pharmaceuticals, Inc.	1974-01-15
不孕	美国	Ferring Pharmaceuticals, Inc.	1974-01-15

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适应症	最高研发状态	国家/地区	公司	日期
不孕	临床2期	瑞士	Ferring BV	2022-09-05

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01225835 (CTgov)	临床4期	不孕	124	Menotrophin+Choriongonadotropin+Cetrorelix+Progesterone (Menotrophin)	壓顧積艱願餘蓋鹽製窪(淵艱淵鬱淵夢鏇構衊襯) = 鬱鹹衊鹽餘築廠選齋鏇鑰壓製淵壓膚顧築壓淵 (鹽壓範壓襯鏇遞壓夢觸, 繭醖糧醖淵膚淵網顧衊 ~ 觸獵構窪鏇淵構繭憲壓) 更多	-	2014-02-11
				Choriongonadotropin+Cetrorelix+Progesterone+Follitrophin alpha (Follitrophin Alpha)	壓顧積艱願餘蓋鹽製窪(淵艱淵鬱淵夢鏇構衊襯) = 網顧壓構遞構衊鑰衊築鑰壓製淵壓膚顧築壓淵 (鹽壓範壓襯鏇遞壓夢觸, 積鏇齋選簾襯觸鬱衊壓 ~ 網構製製齋蓋壓夢鬱製) 更多