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更新于：2026-05-16
Lotiglipron
洛替格列酮
更新于：2026-05-16
概要
基本信息
原研机构 |
在研机构- |
非在研机构 |
权益机构- |
最高研发阶段终止临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C31H31ClN4O5 |
InChIKeySVPYZAJTWFQTSM-UGDMGKLASA-N |
CAS号2401892-75-7 |
关联
12
项与 洛替格列酮 相关的临床试验NCT05788328
A PHASE 1, OPEN-LABEL, FIXED-SEQUENCE STUDY TO ESTIMATE THE EFFECT OF PF-07081532 ADMINISTRATION ON THE SINGLE-DOSE PHARMACOKINETICS OF DABIGATRAN AND ROSUVASTATIN IN OVERWEIGHT OR OBESE ADULT PARTICIPANTS
The purpose of the study was to understand the effect of PF-07081532 on the movement of Dabigatran and Rosuvastatin into, though, and out of the body in healthy overweight or obese adult participants. This study also aims to collect data on safety and how tolerable the study medicine is.
The study is seeking for participants who are:
* Male or female who are 18 years of age or older.
* Healthy but are overweight or obese. Participants will receive dabigatran and rosuvastatin as single doses by mouth 3 times during the study. The amount of the study medicine PF-07081532 will be adjusted over time until any interactions are seen.
PF-07081532 is taken daily by mouth in 8 Study Periods while admitted into the study clinic over 53 days. Once discharged from the study clinic, participants will have a follow-up visit 7 to 10 days post last dose of study medicine. Then another follow-up via telephone contact, 28 to 35 days post last dose of study medicine.
The study is seeking for participants who are:
* Male or female who are 18 years of age or older.
* Healthy but are overweight or obese. Participants will receive dabigatran and rosuvastatin as single doses by mouth 3 times during the study. The amount of the study medicine PF-07081532 will be adjusted over time until any interactions are seen.
PF-07081532 is taken daily by mouth in 8 Study Periods while admitted into the study clinic over 53 days. Once discharged from the study clinic, participants will have a follow-up visit 7 to 10 days post last dose of study medicine. Then another follow-up via telephone contact, 28 to 35 days post last dose of study medicine.
开始日期2023-03-27 |
申办/合作机构 |
NCT05745701
A PHASE 1, OPEN-LABEL, FIXED-SEQUENCE STUDY TO EVALUATE THE EFFECT OF ITRACONAZOLE AND CYCLOSPORINE ON THE SINGLE-DOSE PHARMACOKINETICS OF PF-07081532 IN OVERWEIGHT OR OBESE ADULT PARTICIPANTS
This is a Phase 1, open-label, fixed-sequence, 3-period study to evaluate the effect of multiple doses of itraconazole and a single dose of cyclosporine on the single-dose PK of PF-07081532 in otherwise healthy, overweight or obese, adult female and male participants.
The 3 study periods will be conducted consecutively without a break.
The 3 study periods will be conducted consecutively without a break.
开始日期2023-02-22 |
申办/合作机构 |
NCT05671653
A PHASE 1, OPEN-LABEL, FIXED-SEQUENCE STUDY TO EVALUATE THE EFFECT OF TWO STEADY-STATE DOSE LEVELS OF PF-07081532 ON THE PHARMACOKINETICS OF SINGLE-DOSE MIDAZOLAM, OMEPRAZOLE AND AN ORAL CONTRACEPTIVE, AND THE EFFECT OF STEADY-STATE SEMAGLUTIDE ON THE PHARMACOKINETICS OF SINGLE-DOSE MIDAZOLAM, IN OBESE ADULT FEMALE PARTICIPANTS
Two different groups of healthy volunteers will be chronically treated with GLP-1 drugs PF-07081532 or alternatively Semaglutide. The effect of these GLP-1 drugs on a single dose of the common sedative medication midazolam blood levels will be measured. The effect of chronic PF-07081532 on single doses of the common stomach acid medication omeprazole, and common birth control medication blood levels will also be measured. The hypothesis is that chronic administration of the GLP-1 drugs will minimally affect blood levels from these common medications.
开始日期2023-01-19 |
申办/合作机构 |
100 项与 洛替格列酮 相关的临床结果
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100 项与 洛替格列酮 相关的转化医学
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100 项与 洛替格列酮 相关的专利（医药）
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5
项与 洛替格列酮 相关的文献（医药）2025-08-26·CURRENT MEDICINAL CHEMISTRY
"Next-in-class" GLP-1R Danuglipron- and Lotiglipron-like Agonists: A Patent Review (2020-2024)
Article
作者: Elena V. Tolkacheva ; Konstantin V. Balakin ; Roman A. Ivanov ; Tagir L. Salakhov ; Alexandr Yu. Saliev ; Vladimir V. Chernyshov
Background::
GLP-1 receptor peptide agonists have revolutionized type 2 di-abetes mellitus and obesity treatment, primarily through injection-based therapies. Small-molecule GLP-1 receptor agonists allow oral administration, but none are clini-cally established. Pfizer's danuglipron and lotiglipron, presented in 2018-2019, were "first-in-class" drug candidates, becoming prototypes for "next-in-class" drug develop-ment.
Objective::
This review summarizes "next-in-class" GLP-1 receptor agonists developed, identifying different relationships between the molecular structure and functional activi-ty of agonists.
Methods::
Patents containing danuglipron- and lotiglipron-like agonists from January 2021 to July 2024 were browsed in databases, such as Espacenet and Google Patents, using specified keywords. Over 5,000 compounds from 67 patent publications were an-alyzed.
Results::
Our analysis identified some key general SAR trends. The presence of a car-boxyl group leads to highly active agonists, but replacing it with bioisosteric analogs may improve the ADME profile of the target compounds. The introduction of specific privileged fragments, as well as the replacement of 1H-benzo[d]imidazole nucleus or (S)-oxetan-2-ylmethyl substituent in the prototype structure with bioisosteric heterocy-cles, may be viable approaches. The replacement of 1,4-disubstituted piperidine linked with its (S)-2-methyl-substituted homologue or O, N-disubstituted piperidin-4-ol may also result in highly potent agonists. Additionally, the classic 2,4-EWG-disubstituted benzyl alcohol residue allows significant variability.
Conclusion::
Despite the limited clinical success of danuglipron and lotiglipron, as well as the inherent problems associated with the complex nature of GLP-1R signaling, the current state of research and the abundance of novel, promising chemotypes of highly potent compounds suggest that approved GLP-1R agonists may emerge in the coming years.
2025-01-01·DIABETES OBESITY & METABOLISM
Evaluation of an oral small‐molecule glucagon‐like peptide‐1 receptor agonist, lotiglipron, for type 2 diabetes and obesity: A dose‐ranging, phase 2, randomized, placebo‐controlled study
Article
作者: Buckley, Gina ; Vasas, Szilard ; Haggag, Amina Z. ; Frederich, Robert ; Amin, Neeta B. ; Palmer, Alexandra ; Zhu, Qi ; DuBrava, Sarah J. ; Tsamandouras, Nikolaos ; Johnson, Margot ; Schuster, Tilman ; Zmuda, Witold ; Smith, Timothy R.
Abstract:
Aim:
The aim was to investigate the effects of lotiglipron, a once‐daily, oral small‐molecule glucagon‐like peptide‐1 (GLP‐1) receptor agonist, in participants with type 2 diabetes (T2D) or obesity.
Materials and Methods:
A phase 2, randomized, double‐blind, placebo‐controlled, dose‐ranging study investigated the efficacy and safety of lotiglipron. The study was terminated early for safety reasons after routine data and monitoring review. The planned analyses for the end points were modified prior to unblinding the study.
Results:
In total, 901 participants were treated with at least one dose of the study drug (T2D cohort:
n
= 512, obesity cohort:
n
= 389). Although the majority of participants who were randomly assigned to higher doses did not reach their target maintenance dose, statistically significant changes in HbA1c and body weight were observed. In the T2D cohort, reductions in HbA1c were observed across all lotiglipron doses at week 16 (
p
< 0.0001), with least squares mean decreases up to −1.44% (90% confidence interval [CI]: −1.63, −1.26) (lotiglipron 80 mg), versus placebo, −0.07% (90% CI: −0.25, 0.11). In the obesity cohort, decreases in body weight were observed across all lotiglipron doses at week 20 (
p
< 0.01), up to −7.47% (90% CI: −8.50, −6.43) (lotiglipron 200 mg, five‐step titration), versus placebo, −1.84% (90% CI: −2.85, −0.83). Across cohorts, the most frequently reported treatment‐emergent adverse events were gastrointestinal related (most mild to moderate severity), with nausea being the most common (ranging from 4% [placebo] to 28.8% [80 mg] in the T2D cohort and 12.5% [placebo] to 60.6% [200 mg, four‐step titration] in the obesity cohort). Transaminase elevations were observed in a subset of participants (6.6% and 6.0% of participants on lotiglipron in the T2D and obesity cohorts, respectively, compared with 1.6% on placebo in the obesity cohort).
Conclusions:
The efficacy (HbA1c and/or body weight) of a range of lotiglipron doses was demonstrated in T2D and obesity cohorts. The safety profile was largely consistent with what has been previously known about the mechanism of action. Our results are unique in reporting elevations in liver transaminases in a subset of participants treated with lotiglipron, with attempts to identify the at‐risk population unsuccessful and therefore clinical development of lotiglipron terminated.
ClinicalTrials.gov:
NCT05579977.
2024-12-18·Science Translational Medicine
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron
Article
作者: Willard, Francis S. ; Suter, Todd M. ; Emmerson, Paul J. ; Padgett, Leah R. ; Hewitt, Natalie ; White, Alex ; O’Farrell, Libbey S. ; Peterson, Jeffrey A. ; Sangwung, Panjamaporn ; Liu, Zhaomin ; Wainscott, David B. ; Coskun, Tamer ; Ruble, J. Craig ; Cox, Amy L. ; Sloop, Kyle W. ; Showalter, Aaron D. ; Snider, Brandy M. ; Coutant, David E. ; Dunbar, James D. ; Stutsman, Cynthia ; Woerly, Eric M. ; Ai, Minrong ; Droz, Brian A.
Orally bioavailable, synthetic nonpeptide agonists (NPAs) of the glucagon-like peptide-1 receptor (GLP-1R) may offer an effective, scalable pharmacotherapy to address the metabolic disease epidemic. One of the first molecules in the emerging class of GLP-1R NPAs is orforglipron, which is in clinical development for treating type 2 diabetes and obesity. Here, we characterized the pharmacological properties of orforglipron in comparison with peptide-based GLP-1R agonists and other NPAs. Competition binding experiments using either [
125
I]GLP-1(7-36)NH
2
or [
3
H]orforglipron indicated that orforglipron is a high-affinity [inhibition constant (
Ki
) = 1 nM], selective ligand of the human GLP-1R. Signal transduction assays showed that orforglipron has low intrinsic efficacy for effector activation and negligible β-arrestin recruitment. To evaluate GLP-1R engagement in vivo, mice expressing the human GLP-1R were administered orforglipron and subjected to a glucose tolerance test. Predicted receptor occupancy was calculated using the receptor
Ki
value of orforglipron and its unbound concentration in vivo that reduces hyperglycemia. These experiments revealed that low GLP-1R occupancy by orforglipron is sufficient to yield a full biological response. Moreover, in a model where CRISPR-Cas9 gene editing was used to sensitize the rat GLP-1R (
Glp1r
S33W
) to GLP-1R NPAs, target engagement by orforglipron in the pancreas and brain was consistent with peptide-based GLP-1R agonists. Diet-induced obesity in
Glp1r
S33W
rats enabled studies showing weight loss in animals orally administered orforglipron versus subcutaneous injection of GLP-1R agonist semaglutide. Furthermore, crossover studies indicated oral orforglipron can sustain efficacy initiated by parenteral semaglutide. The pharmacological properties of orforglipron may inform targeting of other peptide receptors with NPAs.
156
项与 洛替格列酮 相关的新闻（医药）2026-05-16
·精准药物
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近日，在药物化学权威期刊Journal of Medicinal Chemistry上发表了一篇题为"成功优化中发生了什么？——2018−2024年文献调研"的观点论文，资深药物化学家Paul D. Leeson对2018至2024年间478对起始化合物-候选药物优化组合进行了迄今最大规模的公开文献调研，系统剖析了成功优化的分子轨迹与策略演变。
该研究覆盖487个优化配对，涵盖激酶、GPCR、蛋白酶等主要靶标类别，以及肿瘤、CNS、感染等多元疾病领域。分析表明，口服候选药物中86.3%符合Lipinski五规则（Ro5），优化过程中分子量平均增加81 Da，但脂溶性（logP）基本维持不变——这一"分子生长"与"脂溶性控制"的平衡已成为当代药物优化的核心范式。研究深入揭示了优化背后的结构驱动力：sp³杂化碳原子、氢键受体、杂芳环及天然产物片段的引入显著增加，而碳芳环数量趋于减少；候选药物平均保留起始化合物70%的最大公共子结构，体现了"保守修饰"与"理性跃迁"并存的优化哲学。
尤为值得关注的是，作者对"先导化合物样"（lead-like）概念的当代适用性进行了重新审视——鉴于分子膨胀趋势，仅23%的筛选命中符合传统的MW<<350且clogP<<3标准，远低于1995年前的58%。研究同时追踪了超越Ro5（bRo5）空间的新兴候选药物，包括PROTAC、分子胶和大环肽等"新模态"分子的理化性质特征，为日益拓展的口服可药性边界提供了数据支撑。此外，作者结合KRAS抑制剂、EGFR第三代药物、口服GLP-1激动剂等大量经典案例，生动诠释了从高通量筛选到片段筛选、从已知化合物到天然产物等多样化起点的优化路径差异。
该文不仅是对近七年成功优化实践的系统性"解剖"，更为药物化学家设计筛选库、制定优化策略及评估候选质量提供了循证指南，对AI/ML时代下"数字药物化学家"如何融合计算预测与人类直觉亦具有重要启示意义。
Introduction
先导化合物发现与优化是药物化学的核心。早期研究表明优化过程中分子量和脂溶性均增加，由此提出"先导化合物样"假说：理想筛选库应含低分子量（MW<<350）和低脂溶性（logP<<3）的分子，以便为后续多参数优化保留"分子生长"空间；类似原则也是片段药物发现（FBDD）成功的基石。近期研究证实优化中分子量增加而脂溶性不变，且起始化合物与候选药物的分子量均高于历史数据。配体效率指标（尤其是LLE）在优化中通常增加。大规模回顾性研究发现候选药物系列脂溶性更低、sp³碳比例更高，且25%的候选药物在合成不足60个化合物后即出现。为获得当代优化趋势，本研究自2018年起系统收集487对起始化合物−候选药物配对，分析疾病领域、靶标类别、化学起点、给药途径和作用模式的影响。同期Brown和Rácz等团队也开展了类似研究，显示大多数临床候选药物来源于已知化合物，筛选来源的候选药物分子量平均增加约80 Da，而脂溶性和氢键供体数量基本不变。本数据集为迄今公开来源最大规模，且在起始化合物来源判定和分子性质分析范围上更为全面，涵盖原子类型变化、环系、天然产物片段及共享子结构等。
Results
①数据收集
本研究手动收集2018−2024年间通向候选药物的"成功"优化配对，未采用关键词检索。因部分文献未明确区分hit-to-lead阶段，主要分析限定为"起始到终点"的完整配对。纳入标准包括明确进入临床或高级临床前阶段且优化路径清晰的化合物，498个候选药物中JMC贡献68%，专利优先日期集中于2011−2016年，平均文献发表滞后7.0年。487个配对具有可识别化学起点，其中469个报告了体外活性，2015年后候选药物平均分子量从466升至506。起始化合物按既有优化程度分为六类：现有药物（12%）、已知化合物（27%）、药效团假说（7%）、定向筛选（12%）、片段筛选（5%）和多样性筛选（37%），DNA编码库筛选仅占0.8%。与Brown分类的关键差异在于本研究进一步细分已知化合物并追溯其原始筛选来源，使多样性筛选占比升至37%。数据收集存在手工筛选无法穷尽、部分候选药物被终止开发未明确标识、分类主观性等局限。理化性质通过SWISS ADME、DataWarrior和ADMETLab3计算，经比较确定XLogP3最优；体外活性转换为p(activity)，以XLogP3计算LLE；选用MCE-18评估分子复杂度，同时分析天然产物片段、伪天然产物及环系变化，并确定每对的最大公共子结构（MCS）。
②总体性质变化趋势
Table 1汇总了487对起始化合物−候选药物配对的关键性质数据。与早期研究一致，候选药物在分子量（MW，平均+81 Da）、重原子数（HA，+5.7）、总表面积（TSA，+53 Ų）、摩尔折射率（MR，+18.9）、氢键受体（HBA，+2.0）、拓扑极性表面积（TPSA，+17.6 Ų）、可旋转键（+1.1）、氟原子数（+0.6）和活性（p(activity)，+1.5）上普遍增加；而脂溶性（cLogP、XLogP3、logD）、氢键供体（HBD）、OH+NH计数、氯原子和硫原子数平均变化极小或无变化。Figure 3显示，起始化合物的MW高度依赖其来源（多样性筛选起始MW最低，药物最高），但优化后候选药物的MW趋于一致（中位数445−482 Da），其中多样性筛选的MW增幅最大（中位数+76），药物最小（+27），片段筛选是唯一脂溶性显著增加的类别（XLogP3平均+1.4）。Figure 4进一步展示，按靶标类别、疾病领域、作用机制和给药途径分类时，靶标类别对性质差异的影响最为显著且贯穿优化始终：CNS候选药物MW最低，呼吸疾病（含吸入给药）候选MW最高；激动剂XLogP3高于拮抗剂/抑制剂；口服候选MW低于胃肠外和外用制剂；3D t-SNE图显示，来源于筛选策略的起始化合物与候选药物在化学空间中密度差异较文献来源更为明显。
③效力与配体效率演变
在全数据集中，活性平均增加1.5个数量级，伴随MW等体积参数增加和脂溶性基本不变。Figure 5按起始来源和靶标类别展示效力优化轨迹：按起始来源，MW−p(activity)向量方向近乎一致，片段、多样性筛选等低MW起点的活性增幅最大；按靶标类别，轨迹呈平行但分离状态，提示靶标类别决定了不同的平均性质起点和终点。由于HA数与p(activity)同步增加，传统配体效率（LE）在优化中基本不变（平均变化为0），但尺寸独立配体效率（SILE）在所有类别中均增加；脂溶性配体效率（LLE）因活性增加而脂溶性不变，在全集中平均增加1.6，其中多样性筛选组的LLE提升同时受益于活性增加（p(activity)+1.9）和脂溶性降低（XLogP3−0.5）。
④复杂度与结构特征变化
HA增加几乎完全由六种原子类型贡献，依次为：Csp³（+2.77）> 芳环氮（ArN，+0.77）> 氧（+0.63）≈ Csp²+Csp¹（+0.62）≈ 氟（+0.60）> 非芳环氮（+0.24）。Figure 6和Figure 7的归一化分析显示，每100个HA中Csp³原子净增4.6个，而Csp²+Csp¹净减7.0个；氢键受体显著增加，氢键供体变化微弱；碳芳环减少，杂芳环和脂环增加。Figure 8表明，片段起始的杂芳环密度在优化中几乎不变，而激酶起始的杂芳环密度最高但在优化中减少，这与ATP结合位点需要富氮杂环的先例有关；所有靶标类别的碳芳环均减少。Figure 9将性质变化归一化后分为四象限：合成可及性、可旋转键、TPSA等增加与HA增加成正比；碳芳环、HBD和Csp²+Csp¹增加不足；氟原子、立体中心、脂环和杂芳环增加超过HA比例但增加配对不足50%；仅MCE-18复杂度、Csp³计数、HBA和天然产物片段同时满足"增加超过HA比例"且"超过50%配对增加"。Figure 10以立体中心、杂脂环和碳脂环的组合变化作为脂族复杂度代理指标，27种可能组合中出现24种，仅8%的配对至少一项减少而其余不变，56%的配对至少一项增加而其余不变。
⑤片段优化与复杂/非复杂分类
Table 3显示，本研究23个片段候选药物的芳环数均值（3.48）高于其他464个候选药物（2.96），Fsp³更低，Ar−Csp³差值更高；与54个文献报道的FBDD临床化合物比较，芳环含量一致，但198个文献片段先导化合物因多为未推进至临床的"不成功"分子而芳环含量更高。Figure 11进一步展示，文献片段先导的杂芳环密度高于本研究片段候选，而临床阶段FBDD化合物与本研究轨迹一致。Figure 12将MCE-18与MW关联分析，发现61个候选药物（9.2%）和150个起始化合物处于"非复杂"区域（MCE-18<<45，主要为芳环连接无环非手性基团的"旧式"分子），其中46个候选来自同样非复杂的起始点，其余15个来自更复杂的起点；另有104个非复杂起始化合物在优化中增加了MCE-18复杂度。
⑥环系、天然产物片段与结构保留
Figure 13显示，46个常见环系（在候选中出现≥5次）占所有环系的77.1%，其中吡啶、环丙烷、吡唑、吡咯烷、吗啉、嘧啶和吡喃等在优化中较起始化合物明显增加，氧杂环丁烷未在起始中出现但存在于11个候选中，这些环系均为已知天然产物片段。Figure 14表明，所有起始来源和靶标类别的天然产物（NP）片段计数在优化中均显著增加，药物和已知化合物的增幅最小（约0.5−0.6），激酶候选的NP片段数最高（平均3.3）。候选药物为伪天然产物（PNP）的几率是起始化合物的2.3倍，66%的候选为PNP，而起始为46%。Figure 15分析最大公共子结构（MCS），全数据集平均保留起始化合物70%的重原子框架（中位数70.6%），显著高于100组随机配对的34.4%；按起始来源，多样性筛选的MCS最低（64%），药物最高（78%）；9.4%的配对保留了100%的起始化合物骨架。
⑦成药性规则与先导化合物样性质
Figure 16统计445个口服候选药物的Ro5合规性：86.3%符合Ro5（违反0或1条），13.7%违反>1条；违规主要由MW>500（30.6%）和cLogP>5（14.0%）驱动，OH+NH>5的违规仅4例（0.9%）。90百分位数据显示，传统cutoff（MW 500、cLogP 5）对当前候选偏低，而OH+NH cutoff（5）过高。Figure 17对比显示，本研究中仅23%的筛选命中（多样性、定向和片段筛选）符合1999年提出的先导化合物样标准（MW<<350且cLogP<<3），远低于1995年前历史数据的57.8%；40.5%的筛选命中已具有MW>350且cLogP>3的"类药"特征。Table 4按起始化合物MW四分位分组总结口服优化结果：最低四分位（MW<<330）显示经典的先导化合物行为，MW增幅（+88）、MCE-18增幅（+42）、活性增幅（+2.2）和HBA增幅（+2.6）均为最大，最终候选MW最低（402）且XLogP3最低（2.5）；而高四分位（MW>530）候选MW达558，但各四分位的立体中心和环计数变化相似，HBD、Fsp³和杂芳环数对起始MW依赖较小。
⑧热点靶标的"跟风效应"与系列药物衍生
KRAS G12C抑制剂是典型"跟风"案例：2013年发现的片段 tethering 命中化合物11经优化得到ARS-1620（12），该分子启发了后续一系列候选药物，包括首个获批的sotorasib（17）、adagrasib（19）以及MK-1084（16）、glecirasib（18）、AZD4625（13）、AZD4747（14）、MRTX1133（20）、INCB159020（15）和JDQ443（21）等，体现了基于结构的设计和杂芳环骨架跃迁策略。ATR激酶抑制剂（Figure 19）展示了单一聚焦筛选命中化合物22（含吗啉-嘧啶核心）如何衍生出ceralasertib（24，III期）、ART0380（25）、AD1058（26）、elimusertib（27）、camonsertib（28）和YY2201（29）等多个临床候选。第三代EGFR抑制剂（Figure 20）则围绕奥希替尼（30）展开：为克服N-去甲基代谢途径，分别开发了氘代药物dosimertinib（33）、咪唑并吡啶类似物YK-029A（32）和mobocertinib（31）；此外还有sunvozertinib（34）、limertinib（35）、lazertinib（37）等已获批或临床阶段药物，多数保留母核结构且MW均有增加。
⑨单一HTS命中产生多个候选药物
三个案例展示了同一高通量筛选命中如何导向多个临床候选。PI3Kα亚型选择性抑制剂inavolisib（45）及taselisib（43）、GDC-0326（44）均源自三环HTS命中42，优化中通过环扩张和杂芳环替换增加LLE。Orexin-2受体激动剂oveporexton（49）及danavorexton（47）、firazorexton（48）源自HTS命中46，保留了核心二氨基乙基单元，通过引入偕二氟和叔醇克服代谢毒性。口服GLP-1受体激动剂danuglipron（51）源自HTS命中50，其苯并咪唑骨架在优化中高度保留（MCS=91%），关键步骤为引入羧基模拟肽底物酸性；该系列后续还开发了lotiglipron（52）、DD202-114（53）、DA-302168S（54）和naperiglipron（55），但部分因肝毒性终止。
⑩高MW筛选命中的截短策略与低活性高MW命中的推进
对于高MW筛选命中，截短是常见策略。FGFR抑制剂ASP5878（59）的优化（Figure 22a）从HTS命中56（MW=582）出发，经选择性先导57（MW=760）和溶解性先导58（MW=583），最终通过去除溶剂暴露的碱性哌嗪并降低hERG和清除率，使MW和XLogP3总体降低175 Da和2.8单位，MCS仅22%。sGC激活剂runcaciguat（63）的优化（Figure 22b）从HTS命中60（MW=558）经历酸先导61和4-Cl截短先导62（MW=400），最终MW降至488，同时碳芳环减少2个。Table 5汇总了10个高MW（>470）且低活性（p(activity)<<6.0）命中的优化案例：其中paltusotine（65）、AZD9898（67）和LEOPPPIm（69）通过截短实现MW降低和LE/LLE显著提升；其余案例如ensitrelvir（71）、ABBV/GLPG-3221（73）和CK-136（75）等则适度增加MW（+32至+54），通过氟代或结构替换改善代谢稳定性和渗透性。
基于药效团假说的理性设计
当HTS失败时，基于结构的药效团设计可成功获得起始化合物。Bayer的FXIa抑制剂asundexian（88，Figure 23a）利用BMS专利化合物84和85的信息，通过双羰基靶向FXIa氧阴离子空穴设计得到命中86，经占据P1'口袋优化为候选。BMS的FXIa抑制剂milvexian（95，Figure 23b）则源自聚焦筛选命中89，历时约10年，经SBDD驱动优化，最终通过大环结构94平衡效力与PK，MW从403增至626但脂溶性增幅有限。在MC2拮抗剂atumelnant（98，Figure 24a）的发现中，从选择性MC4拮抗剂96出发，去除外围取代基并断裂亚甲基连接子得到命中97，后续优化保留哌嗪核心，以三氟甲基环丁烷作为生物电子等排体替换苯环。M4正构调节剂emraclidine（102，Figure 24b）则从已知M4 PAMs 99和100出发，通过降低HBD数以促进CNS渗透，得到片段样命中101（MW=230），后续引入氮杂环丁烷-吡啶基团增加效力，最终MW=390且HBD=0，脑/血浆游离比为0.5。
核心骨架保留与低复杂度优化路径
Table 6列举了8个仅需微小结构改动（起始化合物MCS=100%）即获得候选药物的案例，包括sigma-2调节剂（104仅需1个亚甲基添加）、CDK9拮抗剂（106需2个亚甲基和构型翻转）、Wee1抑制剂（116）等；多数活性提升有限，但部分通过引入极性原子（醚氧、腈基）实现活性增加2.0−2.5个数量级。Table 7展示了4个"非复杂"起始化合物优化为"非复杂"候选药物（MCE-18<<45）的案例：vimseltinib（120）保留聚焦筛选命中119的双吡啶醚核心并去除苄基以降低MW和脂溶性；AG-946（122）利用蛋白假C2对称性，具有数据集中最高的杂芳环密度；lirafugratinib（124）保留片段命中123的全部原子；CVN293（126）则仅需单氟化和吡啶→哒嗪替换以降低代谢清除率。
从低复杂度到bRo5空间及芳环趋势例证
Table 8展示4个"非复杂"命中经增加脂族复杂度进入bRo5空间（MW>500且O+N>10）的案例：fenebrutinib（128）在BTK聚焦筛选命中127两端各添加2个脂环，显著增加LLE和激酶选择性；BIIB091（130）源自HTS命中129，同样利用"H3"位点；WRN抑制剂HR0761（132）从ATP结合测定命中131经SBDD优化，MW增加309至702 Da，末端含脱氢吡喃和非经典两性离子5-羟基嘧啶；CFTR调节剂GLPG2737（134）从HTS命中133出发，去除1个碳芳环并增加3个脂环。Table 9则例证了优化中碳芳环减少、杂芳环增加的整体趋势：LPA1拮抗剂admilparant（136）将BMS 986020（135）的3个苯环全部替换，MW降低37 Da，XLogP3降低3.2，溶解度和暴露量显著改善；MC4R拮抗剂PF 07258669（139）通过螺环化策略锁定构象，苯环减少2个、杂芳环增加2个，消除hERG和P450风险；ROMK抑制剂BMS-986308（141）用三唑和吡啶替换2个苯环，XLogP3降低2.4；DGAT2抑制剂ervogastat（143）以双吡啶氧基替换苯氧基哌啶，MW降低69 Da，消除反应性代谢风险。
新模态、特殊起点与给药途径的优化实例
Figure 26展示了PROTAC候选药物的发现：IRAK-4降解剂KT-474将预优化的Cereblon配体与已知IRAK-4抑制剂经linker连接，优化后MW=866且具分子内氢键；BTK降解剂NX-2127和bexobrutideg源自同一lead，通过修饰配体和linker改善暴露极性分布与CNS渗透性。Figure 27−28呈现了天然产物来源的bRo5候选药物：桦木酸衍生的HIV成熟抑制剂系列（GSK3532795、GSK3640254、VH-937）及抗真菌药ibrexafungerp均为口服两性离子；从sanglifehrin A的Cyclophilin A结合域出发，经tethering与大环化策略开发的KRAS分子胶系列（daraxonrasib、elironrasib、zoldonrasib、RMC-5127）MW超过1000，但通过分子内氢键降低溶剂暴露极性以实现口服生物利用度。Figure 29列举了表型筛选来源的候选药物：两个抗利什曼原虫化合物（GSK3186899和GSK3494245）分别从HTS命中经骨架跃迁优化，后分别证实作用于CDK12和蛋白酶体；HSF1通路调节剂CCT361814源自卵巢癌细胞表型筛选，靶标未知但生物标志物调节与通路抑制一致。Table 10汇总了吸入候选药物的设计策略：CHF-6523从idelalisib添加极性基团降低渗透性以延长肺部滞留，AZD8154采用低溶解度策略，AZD4604添加碱性哌嗪增加肺滞留，ENaC抑制剂BI 1265162和ETD001则通过引入极性基团降低渗透性实现长效。Table 11展示了以批准药物为起点的优化：TM38837从rimonabant引入酸性四唑降低logD和CNS渗透实现外周CB1选择性；rilzabrutinib保留ibrutinib全部重原子框架作为可逆共价BTK抑制剂；LNP1892从cinacalcet降低脂溶性和可旋转键数，成为两性离子且跨物种生物利用度高；TUL01101从filgotinib以脂环替换苯环增加脂族复杂度，MW仅增加3 Da而JAK1选择性显著改善。
Conclusions
本分析涵盖2018−2024年文献，实际反映2011−2019年创新；86%口服候选符合Ro5，口服PROTAC、分子胶及AI/ML应用在当前数据集中反映尚有限。优化中起始化合物的低性质值趋于增加而高值趋于降低，整体收敛至候选"规范"；平均分子量增加81 Da与活性提升相关，但靶标类别差异贯穿始终。由于重原子数与活性同步增加，传统配体效率基本不变，而尺寸独立配体效率和脂溶性配体效率平均增加。分子量增长主要由Csp³、芳环氮、氧和氟等原子贡献，伴随杂芳环与脂环增加、碳芳环减少及立体中心增多；仅MCE-18复杂度、Csp³计数、氢键受体和天然产物片段的增加同时超过重原子增长所能解释的程度。优化平均保留起始化合物70%的最大公共子结构。鉴于分子膨胀，仅23%筛选命中符合传统先导样标准，但核心原则未变：理想起始化合物应具备在增加分子量和复杂度的同时提升效力的潜力。值得注意的是，25%的候选药物在合成不足60个化合物后即出现，明确候选目标特征并尽早体内筛选有助于加速识别。当前AI/ML主导策略的案例尚少，尽管计算工具发展迅速，但人类判断仍至关重要；发现时间线可缩短，但临床开发的疗效与安全性瓶颈并未因此解决。展望未来，传统Ro5合规空间仍将是主要来源，支持在筛选库和优化中增加三维脂族环、伪天然产物片段及杂芳环替代苯环；在超越Ro5空间，PROTAC和分子胶等候选预计将增长，溶剂暴露极性与分子内氢键等"变色龙"性质将成为与脂溶性同等关键的设计参数。无论技术如何演进，药物化学家的逻辑思维、创造力与坚持不懈仍是成功优化不可或缺的根本要素。
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2026-05-11
·空之客
今年有幸受邀在CBA年会上分享对减重药物的一些想法，纵使本号一贯口无遮拦地以GLP-1“吹哨人”自居，但能在一众学界和业界大佬们面前大放厥词也属机会难得，于是提前做了些数据准备，也鸣谢和钦佩徐剑锋博士对我这种“异见”的宽容雅量。
1
史无前例的市场规模
减肥药物给整个医药行业带来的最直观冲击，当然是其巨大的市场规模体量，在上市后短短数年内就有两个超重磅分子达到数百亿美元量级，这在人类医药发展史上是史无前例的壮举。
为了直观感受一下这个“史无前例”到底有多夸张，不妨对比历史上前几个“药王”的销售额爬坡速度，除了特殊时期的特殊产物（即使是Comirnaty+Paxlovid组合的峰值也没法跟Sema+Tzp相提并论），GLP-1药物一再刷新着我们对药品销售额爬坡速度的认知。
这样现象级的全新商业化范式，同样带来了我们并不熟悉的市场演变规律。以前代谢类药物因其长期用药的属性，往往需要较长年份才会达到峰值，如果线性外推到减肥药上，其未来峰值预期数字将会极其恐怖；然而不幸的是结论可能恰恰相反，极速爬坡也会导致低垂果实更快被摘完，以美国市场为例，渗透率很快就触及瓶颈期（不一定是见顶、还有待Medicare支付等因素的影响），远快于以往的代谢类重磅品种。
有关美国市场渗透率爬升空间的疑问，此前已有较多论述（参见【药海听涛】GLP1这是什么超预期？），省流版本就是T2D和Obesity都先后走出了“新处方量失速-总处方量走平-销售额走平”的证据链。
诚然，目前减肥药、尤其是Tzp，还在依靠美国以外市场攻城略地，但到底能否在OUS实现与美国类似的支付能力和想象空间还有待观察，至少目前减肥药的OUS占比还远低于像Dapagliflozin这样历史上的重磅代谢药物。
2
一日千里的竞争格局
在以往热度较高的医药研发领域，同质化乃至内卷当然也广泛存在，但一般卷起来总需要数年的时间，且在超重磅品种获得验证后的相当长时间内行业都还会处在巨大的惯性共识当中。然而，减肥药的竞争方向似乎在很短时间就脱离了“低级趣味”，即大家很快就意识到单纯卷减重幅度意思不大，如下图所示，兴趣点已经延展到心血管及其他临床获益、降低不良反应以提高耐受度、维持药效、增肌等等，而更大体重降幅被排在了倒数，如果没记错这是Roche早在2024年R&D Day里就用过的图。
下面两张图本号使用过多次（这是最新版，且数据用CC更新读过），这里只想说明仅看减重药效的提升速度极快，像注射剂型从Sema到Tzp再到Reta，短短两三年就让年减重幅度完成了10%-15%-20%三级跳，而在此基础上继续堆减重的幅度和速度都没有太大空间和边际收益了。
从研发的时间轴来看则更有视觉冲击力，在Sema刚获批之后GLP-1单靶新药（不含）尚有不少企业反射弧稍长，到双靶、三靶、小分子、以及更新靶点等的时代，跟随式开发的速度越卷越快，以至于出现了一年多时间内立项10家以上同机制项目的情况，这应该是在PD-1时代都不曾出现的盛景。
3
波谲云诡的商业策略
减肥药到底怎么卖？笔者以为，到目前无论中美市场都还尚未形成靠谱的商业化策略共识，即LLY、NVO、以及新上市的国内企业所现行使用的方法，都未见得是减肥药的终极形态。
最直接的变量就是支付环节，到底这种全新的健康管理需求由谁以何种方式来支付，特别是支付相关的政策、意愿、能力都是全新课题。在美国市场的核心议题是Medicare是否覆盖减肥适应症，这很大程度上需要观望接下来一年多Bridge过渡计划和BALANCE模式的执行情况；在中国市场医保当然是早已铁板钉钉地表态不覆盖减肥，但在降糖适应症谈判时的大幅降价，未来还很有可能对司美仿制药实施集采，这都可能对全市场价格体系带来巨大冲击。
作为一款消费属性极强的处方药，如何构建直接面向终端用户DTC的营销推广方法，特别是针对用药过程中的各类问题（对于非专业人士而言，有效性和安全性的各种疑问我们不难想象），药企和用户之间如何形成良好的互动反馈机制，目前几乎都还是空白。
尤其是在中国市场，在《广告法》范围内的市场营销玩法显然更丰富多彩，现有厂家也显然尚未形成真正的渠道垄断，但不能确保未来就不会形成“winner takes all”的结局（u1s1，以现在这四款主流品种而论，仅在某书随手截的图来看，“营销感”的差距就肉眼可见）。
4
不容有失的合作并购
史无前例的市场规模很有可能带来史无前例的FOMO心态，因为面对这种战略机遇，几乎任何一家MNC（及其CEO）都不敢于错失，这可能跟之前那些拒绝向I/O或者ADC等热门领域折腰的情形不同。目前虽然减肥药的交易十分活跃，但已经真金白银投入过大钱（至少数十亿量级现金）的MNC也就只有Pfizer和Roche，其实还有相当多的潜在买家，交易余地依然巨大。
在刚才那两张“时间轴内卷图”上观察交易的情况，不难看出，几乎每个细分赛道上，进度靠前且数据扎实的品种都是交易扎堆。由是可以推想，在减肥药后续可能的方向，无论是长效、口服，还是新靶点、新机制，但凡能给出明确获益的品种都会有可能创造巨额交易机会。
综上所述，笔者核心想表达的观点一言以蔽之就是，减肥药从诸多维度来看都是医药发展史上的重大里程碑，因而很多我们习以为常的行业规律都未必适用、甚至要彻底改写。这对于整个行业来说都是机遇和挑战，需要我们探索出能驾驭这样一套全新市场机制的方法，以充分兑现和享受其蕴含的天量价值，就好比《天龙八部》扫地僧所说“只有佛法越高，才能练习更多的绝技”。
往期GLP-1相关分析
【药海听涛】GLP-1真的能成为“肥宅快乐药”吗？
【药海听涛】革命不分先后：GLP-1之争礼来加速剑指诺和诺德
【药海听涛】小无相功 vs 六脉神剑：口服GLP-1药物的不对称竞速
【药海听涛】GLP-1虽好，可不要贪杯哟
【药海听涛】口服小分子GLP-1自折一臂：Pfizer停止开发Lotiglipron
【药海听涛】乔峰vs段誉：激烈到离谱的GLP-1双雄之争
【药海听涛】边际获益是王道：Pfizer口服GLP-1再折一臂
【药海听涛】回眸的代价：Roche以31亿美元收购GLP-1药企Carmot
【药海听涛】获益不明显≈明显没获益：硕迪小分子GLP-1二期数据“不佳”
【药海听涛】一山更比一山高：诺和诺德GLP1+Amylin激动剂一期临床结果惊艳
【药海听涛】GLP-1也不是万能的：2024年欧肝会NASH药物数据更新
【药海听涛】全拿下，一扫光：GLP-1真的会杀死NASH市场吗？
【药海听涛】拮抗还是干不过激动：Amgen公布减肥药MariTide二期数据
我是不是可以自称GLP1“吹哨人”了？
【药海听涛】远在天边还是近在眼前：GLP-1的天花板之谜
【药海听涛】药王的魔咒：GLP-1是真香还是有毒？
【药海听涛】小分子GLP-1迎来青树坪“大捷”？
【药海听涛】哨还在响：TZP登顶药王与GLP1处方量首度下滑
【药海听涛】GLP1这是什么超预期？
2026-04-30
*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放
截至04月30日15点59分，近期共有 579 本期刊发布了 1148 篇文章，其中糖尿病相关的文章共 344 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 109 篇。今日，影响因子最高的文章刊登在 Journal of the American Medical Association (IF: 55.000) 期刊上。
今日头条
Headlines
01 Wound repair and regeneration IF: 03.400 糖尿病足溃疡住院后30天再入院：一项全国性分析
Sanaka, Krishna O, Mitra, Nandita, Margolis, David J, etc.
糖尿病足溃疡是糖尿病成人住院的常见原因，与高发病率和死亡率相关。住院后再入院仍然常见，但描述再入院模式和驱动因素的全国代表性证据有限。
这项回顾性队列研究使用了2022年美国全国再入院数据库，旨在描述30天全因再入院率，识别与再入院相关的因素，并比较美国糖尿病足溃疡住院成人的指标住院和再入院情况。通过诊断代码识别诊断为糖尿病足溃疡的成人住院，并进行调查加权分析以生成全国估计。
在估计的234,797次初始住院中，13.3%的患者在30天内再入院，超过了全国住院患者平均水平8.2%。再入院患者中肾脏疾病、心血管疾病和精神健康状况的患病率更高。多变量分析显示，肾脏疾病、心血管合并症、烟草使用、药物使用障碍和双相情感障碍与再入院风险增加相关。相反，初始住院期间的感染相关诊断和手术，包括骨感染、手术清创和下肢截肢，与再入院风险降低相关。再入院住院时间更长，急性全身性疾病患病率更高。
这些发现表明，糖尿病足溃疡住院后早期再入院主要由全身性医疗不稳定驱动，而非局部感染复发，强调了多学科住院和出院后护理策略的必要性。
本文由 韩玉莲 编辑
扫描二维码查看源文
Wound repair and regeneration | Volume 34, Issue 3
10.1111/wrr.70165
02 Journal of diabetes IF: 03.700 糖尿病神经病变的人口统计学和临床特征：来自2012-2017年韩国国民健康保险服务的数据
Jeong, Su Jin, Kim, Sun Keun, Kim, Chong Hwa, etc.
糖尿病神经病变（DN）是2型糖尿病（T2DM）最常见的慢性并发症，既往研究报告的患病率在23%至54.5%之间。本研究利用韩国国民健康保险服务（NHIS）2012年至2017年的数据，评估了DN的患病率、临床特征及治疗情况。
研究分析了NHIS样本数据中870万按年龄、性别、资格和收入分层的人群。DN的定义采用ICD-10编码（E10.4-E14.4, G59.0, G63.2, G99.0）以及同时开具糖尿病和DN处方的标准。计算了糖尿病患者中每年的DN患病率，并比较了有和无DN患者的治疗模式及患者特征。
结果显示，DN患病率从2012年的23.4%下降至2017年的21.5%。约半数DN患者接受了药物治疗，其中单药治疗比例高达82%，二联治疗占15%，三联治疗占3%。最常处方的药物是α-硫辛酸（52.1%-55.0%），其次是抗惊厥药（30.4%-34.5%）、三环类抗抑郁药、SNRIs和γ-亚麻酸。DN患者通常年龄较大，女性居多，且合并症更多，如高血压、血脂异常、心血管疾病、糖尿病足和截肢。他们更可能使用胰岛素或多种口服降糖药。
结论指出，约四分之一的T2DM患者患有DN，其中半数接受了治疗，主要为α-硫辛酸单药治疗。DN患者往往年龄较大且合并多种疾病，导致住院率更高。
本文由 天纳乾坤 编辑
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Journal of diabetes | Volume 18, Issue 5
10.1111/1753-0407.70196
03 JAMA dermatology IF: 11.000 美国国家银屑病基金会关于GLP-1受体激动剂治疗银屑病的入门指南：综述
Samip Sheth, Joseph F. Merola, Brittany N. Weber, Ronald Prussick, Jensen Yeung, Clive Liu, etc.
美国国家银屑病基金会医学委员会近日在《JAMA dermatology》上发表了一篇综述，为皮肤科医生介绍了GLP-1受体激动剂（GLP-1 RAs）在银屑病治疗中的应用。
银屑病是一种慢性免疫介导疾病，常伴有心血管、代谢、肌肉骨骼、精神、肝脏、肾脏和肺部共病。GLP-1 RAs已获美国食品药品监督管理局批准用于2型糖尿病、肥胖、心血管风险降低、慢性肾脏病、阻塞性睡眠呼吸暂停和代谢功能障碍相关脂肪性肝炎，这些疾病在银屑病患者中常见。新出现的证据表明，GLP-1 RAs和双重葡萄糖依赖性促胰岛素多肽/GLP-1激动剂可能通过免疫调节改善银屑病皮损。如果在大规模随机临床试验中得到证实，基于GLP-1的疗法可能为同时治疗皮肤疾病和心血管代谢共病提供机会。
综述的观察部分指出，GLP-1 RAs与银屑病面积和严重程度指数（PASI）评分降低相关，尤其在肥胖或2型糖尿病患者中。研究报告PASI相对降低约40%至80%，同时生活质量改善，但大多数研究规模较小（7-48例患者）、短期（≤6个月）且缺乏对照组。司美格鲁肽和利拉鲁肽与C反应蛋白、白细胞介素-6、血脂和内脏脂肪减少相关。在小型转化队列中，PASI改善与浅表脂肪和真皮γδ T细胞密度减少相关。GLP-1 RAs可与甲氨蝶呤、环孢素和生物制剂安全联用。不良反应主要为短暂胃肠道症状，胰腺炎和胆囊事件罕见。早期数据显示代谢和免疫调节双重益处。
综述结论认为，基于GLP-1的疗法靶向银屑病中共享的代谢和炎症通路。当前证据支持在选定的代谢共病患者中考虑辅助使用，但最终结论尚需更大规模随机临床试验证实。
本文由 韩玉莲 编辑
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JAMA dermatology | Ahead of Print.
10.1001/jamadermatol.2026.0859
04 Frontiers in endocrinology IF: 04.600 糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析
Fan, Seng, Gai, Ziyue, Ma, Hui, Wen, Ziye, Ma, Chunlei, Fan, Dongying, etc.
一项发表于《Frontiers in Endocrinology》的荟萃分析系统评估了糖尿病视网膜病变（DR）与焦虑、抑郁之间的双向关系。研究共纳入34项观察性研究，涉及383,195例患者，覆盖14个国家。
结果显示，DR患者发生抑郁的风险显著高于非DR患者（OR=1.58，95%CI:1.24-2.02，P<0.001）；反之，抑郁患者发生DR的风险也显著升高（OR=2.13，95%CI:1.53-2.98，P<0.001），提示两者存在双向关系。此外，DR患者发生焦虑的风险是非DR患者的2.23倍（95%CI:1.07-4.68，P=0.033）。
亚组分析表明，研究设计、地区和混杂因素可能是异质性的来源。敏感性分析显示结果总体稳健，但存在发表偏倚。
研究建议，在DR的临床治疗中应重视患者的心理状态，实施个性化心理护理，以改善患者预后。
本文由 韩玉莲 编辑
扫描二维码查看源文
Frontiers in endocrinology | Volume 17, Issue
10.3389/fendo.2026.1764745
中国发表（109）
China
Scientific reports IF: 03.900Ahead of Print.No.01A case control study of subjective sleep characteristics and polycystic ovary syndrome主观睡眠特征与多囊卵巢综合征的病例对照研究DOI: 10.1038/s41598-026-50477-3
Complement Ther Clin Pract IF: 03.000Ahead of Print.No.02Effect of acupoint catgut embedding therapy on polycystic ovary syndrome: a systematic review and meta-analysis穴位埋线疗法对多囊卵巢综合征有效性的系统评价与Meta分析DOI: 10.1016/j.ctcp.2026.102056
Journal of hazardous materials IF: 11.300Ahead of Print.No.03Biomarker-anchored screening of dietary microplastics via a gut microbiota-informed machine learning model基于肠道微生物组信息的机器学习模型实现膳食微塑料的生物标志物锚定筛查DOI: 10.1016/j.jhazmat.2026.142219
Chung-Hua Wai K'o Tsa ChihAhead of Print.No.04[Define benchmarks for low-risk sleeve gastrectomy: based on the greater China metabolic and bariatric surgery database]低风险袖状胃切除术的基准定义：基于大中华区减重代谢手术数据库DOI: 10.3760/cma.j.cn112139-20251110-00525
Orthopaedic surgery IF: 02.100Ahead of Print.No.05Research Progress on Risk Factors for Acute Kidney Injury After Antibiotic-Loaded Bone Cement Spacer Treatment for Periprosthetic Joint Infection抗生素骨水泥间隔物治疗假体周围感染后急性肾损伤危险因素的研究进展DOI: 10.1111/os.70327
Mol Cell Endocrinol IF: 03.600Ahead of Print.No.06Adiponectin ameliorates chronic-intermittent-hypoxia-induced insulin resistance by modulating macrophage inflammation in visceral white adipose tissue脂联素通过调节内脏白色脂肪组织巨噬细胞炎症改善慢性间歇性缺氧诱导的胰岛素抵抗DOI: 10.1016/j.mce.2026.112809
Biomaterials advances IF: 06.000Ahead of Print.No.07A upper critical solution temperature- and synergistic antioxidant-responsive tremella polysaccharide hydrogel for enhancing diabetic wound healing一种上临界溶解温度和协同抗氧化响应的银耳多糖水凝胶促进糖尿病伤口愈合DOI: 10.1016/j.bioadv.2026.214900
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.08Association Between Maternal Diabetes and the Risk of Cancers in Mother-Offspring: A Meta-Analysis of 44.9 Million Pregnancies母亲糖尿病与母子癌症风险的关联：一项基于4490万妊娠的荟萃分析DOI: 10.1111/dom.70835
Scientific data IF: 06.900Ahead of Print.No.09Chinese Food Images for Full-cycle Nutrition Analysis Towards Diabetes Management面向糖尿病管理的全周期营养分析的中餐图像数据集DOI: 10.1038/s41597-026-07334-9
Endocrine journal IF: 02.100Ahead of Print.No.10Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting糖尿病中可溶性肿瘤坏死因子受体：风险感知与受体靶向策略DOI: 10.1507/endocrj.EJ26-0050
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.11Letter to the editor-The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study致编辑的信——估计葡萄糖利用率对美国≥60岁非糖尿病人群全因和心血管死亡率的预测价值：一项基于人群的队列研究DOI: 10.1016/j.dsx.2026.103419
Talanta IF: 06.100Ahead of Print.No.12A novel time-gated luminescent ruthenium(II) complex probe for highly sensitive detection of methylglyoxal in foods and complex biological samples一种新型时间门控发光钌(II)配合物探针用于食品和复杂生物样品中甲基乙二醛的高灵敏检测DOI: 10.1016/j.talanta.2026.129907
Environmental research IF: 07.700Ahead of Print.No.13Long-term exposure to ambient PM(2.5) constituents and risk of microvascular complications among individuals with type 2 diabetes mellitus: a nationwide cohort study in UK长期暴露于环境PM2.5组分与2型糖尿病患者微血管并发症风险：一项英国全国性队列研究DOI: 10.1016/j.envres.2026.124589
Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.14Correlation between fundus color and retinal microcirculation in Type 2 Diabetes Mellitus patients2型糖尿病患者眼底颜色与视网膜微循环的相关性DOI: 10.1016/j.pdpdt.2026.105493
Ophthalmology IF: 09.500Ahead of Print.No.15Decoding Gene-Lifestyle Synergy in Diabetic Retinopathy Development: A Transethnic Prospective Cohort Study解码糖尿病视网膜病变发展中的基因-生活方式协同作用：一项跨种族前瞻性队列研究DOI: 10.1016/j.ophtha.2026.04.017
Biomedizinische Technik IF: 01.800Ahead of Print.No.16RetinalFRNet: retinal vessel segmentation in OCTA images using the feature reconstruction networkRetinalFRNet：利用特征重建网络在OCTA图像中进行视网膜血管分割DOI: 10.1515/bmt-2026-0107
Bioorganic chemistry IF: 04.700Ahead of Print.No.17Puerarin alleviates type 2 diabetes by targeting AKT1 to inhibit ferroptosis: Integrating network pharmacology, proteomics and experimental validation葛根素通过靶向AKT1抑制铁死亡缓解2型糖尿病：网络药理学、蛋白质组学与实验验证的整合研究DOI: 10.1016/j.bioorg.2026.109915
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.18Vildagliptin alleviates cardiomyocyte apoptosis and inflammatory responses in the treatment of non-valvular atrial fibrillation by regulating the NO/sGC/cGMP signaling pathway维格列汀通过调节NO/sGC/cGMP信号通路减轻非瓣膜性心房颤动中的心肌细胞凋亡和炎症反应DOI: 10.1080/08923973.2026.2639559
Cell reports. Methods IF: 04.500Ahead of Print.No.19Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization非模式细菌的多维整合建模鉴定阿卡波糖生物合成优化的工程靶点DOI: 10.1016/j.crmeth.2026.101426
Journal of ethnopharmacology IF: 05.400Ahead of Print.No.20Corrigendum to "Integrative pharmacology reveals the mechanisms of Erzhi Pill, a traditional Chinese formulation, against diabetic cardiomyopathy" [J. Ethnopharmacol., 296, (2022), 115474]对《整合药理学揭示传统中药方剂二至丸抗糖尿病心肌病的作用机制》[J. Ethnopharmacol., 296, (2022), 115474]的勘误DOI: 10.1016/j.jep.2026.121734
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.21Metabolomic signatures of hepatic steatosis reveal heterogeneity in cardiometabolic risk and responses to lifestyle interventions in type 2 diabetes: a post hoc analysis肝脏脂肪变性的代谢组学特征揭示2型糖尿病中心血管代谢风险及生活方式干预反应的异质性：一项事后分析DOI: 10.1186/s12933-026-03194-0
ACS nano IF: 16.000Ahead of Print.No.22Self-Cascading Copper-Based Nanoassemblies Trigger Bacterial Cuproptosis-Like Death and Promote Wound Healing for Diabetic Drug-Resistant Bacterial Infections自级联铜基纳米组装体触发细菌铜死亡样死亡并促进糖尿病耐药细菌感染的伤口愈合DOI: 10.1021/acsnano.5c21619
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.23Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast CancerUSP1抑制剂的设计与合成：与PARP抑制剂在三阴性乳腺癌中的协同抗肿瘤活性DOI: 10.1021/acs.jmedchem.5c03804
ACS nano IF: 16.000Ahead of Print.No.24Clinically Validated Leptin Receptor as a Target for Liposomal Delivery of Metformin in Endometriosis Therapy临床验证的瘦素受体作为脂质体递送二甲双胍治疗子宫内膜异位症的靶点DOI: 10.1021/acsnano.5c18417
Gait & posture IF: 02.400Ahead of Print.No.25Multi-modal sensor fusion in smart footwear to capture altered gait dynamics in patients with diabetic peripheral neuropathy: System validation and clinical applications智能鞋具多模态传感器融合捕捉糖尿病周围神经病变患者步态动力学改变：系统验证与临床应用DOI: 10.1016/j.gaitpost.2026.110196
PloS one IF: 02.600Volume 21, Issue 4No.26Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism蒿甲醚改善1型糖尿病肝损伤及相关的线粒体超微结构和中心碳代谢缺陷DOI: 10.1371/journal.pone.0348214
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 4No.27Metformin: Historical Origins, Mechanisms of Action, and Emerging Clinical Applications二甲双胍：历史起源、作用机制及新兴临床应用DOI: 10.1002/dmrr.70171
Science progress IF: 02.900Volume 109, Issue 2No.28Leukocyte VCS parameters as potential auxiliary markers associated with diabetes and its inflammatory complications: A retrospective cross-sectional study白细胞VCS参数作为糖尿病及其炎症并发症潜在辅助标志物的回顾性横断面研究DOI: 10.1177/00368504261445505
Am J Chin Med IF: 05.500Ahead of Print.No.29Acupuncture for Neuropathic Pain: Mechanisms, Clinical Efficacy and Future Perspectives针灸治疗神经病理性疼痛：机制、临床有效性及未来展望DOI: 10.1142/S0192415X26500254
Future science OA IF: 02.100Volume 12, Issue 1No.30Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis眼科糖基化与糖化研究图谱：一项符合PRISMA规范的文献计量与共引分析DOI: 10.1080/20565623.2026.2663167
International wound journal IF: 02.500Volume 21, Issue 2No.31Analysis of pathogen distribution and associated risk factors for surgical site infections following laparoscopic urological surgeries腹腔镜泌尿外科手术后手术部位感染的病原体分布及相关危险因素分析DOI: 10.1111/iwj.14721
Annals of hematology IF: 02.400Volume 105, Issue 5No.32Low dose of sitagliptin: effectively prevent liver aGVHD and accelerate neutrophil engraftment低剂量西格列汀：有效预防肝脏急性移植物抗宿主病并加速中性粒细胞植入DOI: 10.1007/s00277-026-07036-7
Minerva anestesiologica IF: 02.800Ahead of Print.No.33Efficacy of intranasal insulin in preventing postoperative delirium and its impact on insulin resistance in elderly non-cardiac surgical patients: a systematic review and meta-analysis鼻内胰岛素预防老年非心脏手术患者术后谵妄的有效性及其对胰岛素抵抗的影响：系统评价与荟萃分析DOI: 10.23736/S0375-9393.26.19719-3
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.34Clinical Efficacy of Continuous Nursing Plus Shared Outpatient Care on Remission of Type 2 Diabetes Mellitus延续性护理联合共享门诊管理对2型糖尿病缓解的临床有效性DOI: 10.31083/BJHM49861
Clin Pharmacol Drug Dev IF: 01.800Volume 15, Issue 5No.35Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects二甲双胍/吡格列酮片在空腹和进食条件下的比较药代动力学和生物等效性评估：一项在中国健康受试者中开展的随机研究DOI: 10.1002/cpdd.70063
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 4No.36Clinical Value of High-Channel 12-Lead Holter in Assisting Early Identification of Arrhythmias in High-Risk Populations高通道12导联动态心电图在高危人群心律失常早期识别中的临床价值DOI: 10.31083/BJHM52968
JAHA IF: 05.300Ahead of Print.No.37Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study葡萄糖稳态的适应性负荷、表观遗传生物标志物与全因及心血管死亡：一项前瞻性队列研究DOI: 10.1161/JAHA.125.047287
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.38ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNAZFP36L1通过减少FTO介导的ACSL1 mRNA N6-甲基腺苷去甲基化增强缺血性卒中中的小胶质细胞铁死亡DOI: 10.1002/kjm2.70212
International wound journal IF: 02.500Volume 21, Issue 2No.39RETRACTED: The effect of placing drains and no drains after caesarean section in obese patients on patients' post-operative wound complications: A meta-analysis已撤回：肥胖患者剖宫产后放置引流管与不放置引流管对术后伤口并发症影响的荟萃分析DOI: 10.1111/iwj.14576
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Gut microbiome dysbiosis in PCOS: from pathogenesis to microbiome-targeted therapies多囊卵巢综合征中的肠道微生物群失调：从发病机制到微生物靶向治疗DOI: 10.3389/fendo.2026.1747766
BMC public health IF: 03.600Ahead of Print.No.41Associations between multiple air pollutants and insulin resistance in Chinese adults: the moderating role of physical activity多种空气污染物与中国成年人胰岛素抵抗的关联：体力活动的调节作用DOI: 10.1186/s12889-026-27595-8
Reprod Biol Endocrinol IF: 04.700Volume 24, Issue 1No.42Editorial expression of concern: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK编辑关注声明：白藜芦醇通过激活AMPK缓解小鼠妊娠期糖尿病DOI: 10.1186/s12958-026-01560-x
Fayixue zazhiVolume 42, Issue 1No.43[Synthetic Drug： Pregabalin]合成药物：普瑞巴林DOI: 10.12116/j.issn.1004-5619.2026.360302
BMC ophthalmology IF: 01.700Volume 26, Issue 1No.44Correlation between the expression levels of miR-199a-3p and FN1 in serum and aqueous humor and the severity of type 2 diabetic retinopathy in a Chinese population中国人群中血清和房水中miR-199a-3p与FN1表达水平与2型糖尿病视网膜病变严重程度的相关性DOI: 10.1186/s12886-026-04838-1
BMC endocrine disorders IF: 03.300Ahead of Print.No.45The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis抗阻训练改善2型糖尿病β细胞功能的作用：系统综述与荟萃分析DOI: 10.1186/s12902-026-02286-y
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.46Extracellular vesicles inherit lactate from aggregated MSCs to alleviate type 1 diabetes mellitus via H(2)S-induced CD8(+) T cell exhaustion细胞外囊泡继承聚集间充质干细胞的乳酸通过H2S诱导CD8+ T细胞耗竭缓解1型糖尿病DOI: 10.1186/s12951-026-04466-3
Frontiers in psychiatry IF: 03.200Volume 17, Issue No.47The associations of systemic inflammation and insulin resistance-related indicators with psychopathology and BDNF in patients with chronic schizophrenia慢性精神分裂症患者全身炎症和胰岛素抵抗相关指标与精神病理学及BDNF的关联DOI: 10.3389/fpsyt.2026.1802167
Frontiers in neurology IF: 02.800Volume 17, Issue No.48Beyond BMI: independent and opposing effects of overweight and obesity and triglycerides on 90-day functional outcomes after acute ischemic stroke超越体重指数：超重与肥胖和甘油三酯对急性缺血性卒中后90天功能结局的独立且相反的影响DOI: 10.3389/fneur.2026.1782157
Frontiers in immunology IF: 05.900Volume 17, Issue No.49Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders从免疫代谢角度靶向调控脂肪组织巨噬细胞：肥胖相关代谢性疾病的新治疗策略DOI: 10.3389/fimmu.2026.1803488
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.50Association between stress hyperglycemic ratio and stroke in older people with metabolic syndrome: a prospective cohort study from UK Biobank应激性高血糖比率与代谢综合征老年人群卒中风险的关联：一项来自英国生物样本库的前瞻性队列研究DOI: 10.3389/fendo.2026.1758847
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.51Endocrine-informed monitoring of scoliosis in Prader-Willi syndrome: integrating neuroendocrine pathophysiology, growth hormone therapy, and pubertal transitionPrader-Willi综合征脊柱侧弯的内分泌指导监测：整合神经内分泌病理生理学、生长激素治疗与青春期过渡DOI: 10.3389/fendo.2026.1803919
FCVM IF: 02.900Volume 13, Issue No.52Efficacy and safety of levosimendan in acute heart failure patients with different body mass index: a multicenter, retrospective, observational real-world study左西孟旦在不同体重指数急性心力衰竭患者中的有效性和安全性：一项多中心、回顾性、观察性真实世界研究DOI: 10.3389/fcvm.2026.1790085
Frontiers in nutrition IF: 05.100Volume 13, Issue No.53The correlation between nutrition index scores and nutrition status of preschool children in a district of Shanghai上海市某区学龄前儿童营养指数评分与营养状况的相关性研究DOI: 10.3389/fnut.2026.1746871
Frontiers in nutrition IF: 05.100Volume 13, Issue No.54Associations of umbilical cord vitamin D levels with childhood cardiometabolic risks: a longitudinal mother-child study脐带维生素D水平与儿童期心脏代谢风险的关联：一项纵向母婴研究DOI: 10.3389/fnut.2026.1777909
Frontiers in nutrition IF: 05.100Volume 13, Issue No.55Fasting blood glucose to high-density lipoprotein cholesterol ratio and MASLD risk: non-linear association and BMI mediation in non-diabetic adults空腹血糖与高密度脂蛋白胆固醇比值与非糖尿病成人脂肪性肝病风险的非线性关联及体重指数的中介作用DOI: 10.3389/fnut.2026.1818931
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.56Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus妊娠期糖尿病孕妇孕中期甘油三酯-葡萄糖指数及其衍生指数对巨大儿的预测价值DOI: 10.2147/DMSO.S577687
J Int Med Res IF: 01.500Volume 54, Issue 4No.57A metabolic-inflammatory phenotype of pelvic floor dysfunction: A machine learning-based cross-sectional study in a nationally representative US population盆底功能障碍的代谢炎症表型：一项基于机器学习、具有全国代表性的美国人群横断面研究DOI: 10.1177/03000605261438949
J Int Med Res IF: 01.500Volume 54, Issue 4No.58Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study抑郁患者人体测量指标与死亡风险的关联：一项基于人群的队列研究DOI: 10.1177/03000605261442794
Am J Respir Cell Mol Biol IF: 05.300Ahead of Print.No.59FTO Alleviates COPD Pathogenesis by Demethylating S100A9 to Suppress ERK1/2-Drp1-Driven MitophagyFTO通过去甲基化S100A9抑制ERK1/2-Drp1驱动的线粒体自噬减轻COPD发病机制DOI: 10.1093/ajrcmb/aanag094
Diabetology & metabolic syndrome IF: 03.900Volume 18, Issue 1No.60Beyond the known: prospective research directions for the gut-brain axis in obesity and type 1 diabetes mellitus超越已知：肥胖与1型糖尿病中肠脑轴的未来研究方向DOI: 10.1186/s13098-025-02038-3
BMC women's health IF: 02.700Ahead of Print.No.61PCOS combined with obesity aggravates the metabolic and immune abnormality in females多囊卵巢综合征合并肥胖加重女性代谢与免疫异常DOI: 10.1186/s12905-026-04492-1
International wound journal IF: 02.500Volume 21, Issue 2No.62Evaluation of diabetic foot care knowledge, determinants of self-care practices and the efficacy of health education糖尿病足护理知识、自我护理实践的决定因素及健康教育的有效性评估DOI: 10.1111/iwj.14704
International wound journal IF: 02.500Volume 21, Issue 2No.63RETRACTED: Efficacy of autologous platelet-rich plasma combined with negative pressure sealing drainage in the treatment of patients with diabetic foot ulcer自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡患者的有效性：一项系统评价与荟萃分析DOI: 10.1111/iwj.14700
International wound journal IF: 02.500Volume 21, Issue 2No.64RETRACTED: Effects of continuing nursing intervention on high-risk patients with diabetic foot ulcers: A meta-analysis持续护理干预对高危糖尿病足溃疡患者有效性的荟萃分析DOI: 10.1111/iwj.14683
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.65Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression大黄素通过抑制HIF-1α表达减轻糖尿病肾病大鼠脂质蓄积和肾小管损伤DOI: 10.31083/FBL49862
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.66Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina内源性FGF21缺乏对视网膜炎症微环境的影响DOI: 10.31083/FBL47702
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.67Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale眼部血管参数与基底节和半卵圆中心血管周围间隙扩大的区域关联DOI: 10.31083/JIN49070
J Diabetes Investig IF: 03.000Ahead of Print.No.68Comment on 'Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study'对《慢性冠状动脉综合征患者的血糖控制与肾功能下降：一项多中心队列研究》的评论DOI: 10.1111/jdi.70325
Materials horizons IF: 10.700Ahead of Print.No.69Multi-kingdom biofilms breached: microneedle delivery of metabolically targeted organic silver-photosensitizers for polymicrobial infections in diabetic foot ulcers多界生物膜突破：微针递送代谢靶向有机银光敏剂治疗糖尿病足溃疡中的多种微生物感染DOI: 10.1039/d6mh00459h
J Diabetes Investig IF: 03.000Ahead of Print.No.70Letter to the Editor in response to the article 'Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis'对《亚洲2型糖尿病成人肌少症的患病率与危险因素：系统综述与荟萃分析》一文的致编辑信DOI: 10.1111/jdi.70323
Frontiers in surgery IF: 01.800Volume 13, Issue No.71Risk factors associated with postoperative necrosis after digital replantation: a systematic review and meta-analysis断指再植术后坏死相关危险因素的系统评价与Meta分析DOI: 10.3389/fsurg.2026.1795247
Frontiers in neurology IF: 02.800Volume 17, Issue No.72Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis首次卒中后认知障碍发生率的系统评价与荟萃分析DOI: 10.3389/fneur.2026.1782749
Frontiers in physiology IF: 03.400Volume 17, Issue No.73Efficacy and safety of gabapentinoid combination therapy versus monotherapy for the treatment of neuropathic pain加巴喷丁类药物联合治疗与单药治疗神经病理性疼痛的有效性和安全性比较DOI: 10.3389/fphys.2026.1802999
Frontiers in medicine IF: 03.000Volume 13, Issue No.74Incidence and risk factors of oral mucosal pressure injury in patients with oral tracheal intubation: systematic review and meta-analysis经口气管插管患者口腔黏膜压力性损伤发生率及危险因素的系统评价与Meta分析DOI: 10.3389/fmed.2026.1783726
Frontiers in medicine IF: 03.000Volume 13, Issue No.75Association between serum 25-hydroxyvitamin D, nutritional status, and inflammatory markers in sepsis patients with and without sarcopenia脓毒症合并与不合并肌少症患者血清25-羟基维生素D、营养状态和炎症标志物的关联研究DOI: 10.3389/fmed.2026.1816016
Frontiers in medicine IF: 03.000Volume 13, Issue No.76Construction and validation of a machine learning-based prediction model for postoperative complications in patients with chronic otitis media基于机器学习的慢性中耳炎术后并发症预测模型的构建与验证DOI: 10.3389/fmed.2026.1805224
Frontiers in medicine IF: 03.000Volume 13, Issue No.77Impact of liuwei dihuang pills (decoction) on early diabetic nephropathy: a systematic review and meta-analysis六味地黄丸（汤）对早期糖尿病肾病影响的系统评价与Meta分析DOI: 10.3389/fmed.2026.1802975
Maternal-fetal medicine IF: 01.700Volume 8, Issue 2No.78Global Guidelines on Placenta Accreta Spectrum Disorders: A Commentary From the Chinese Perspective全球胎盘植入性疾病指南：来自中国视角的评论DOI: 10.1097/FM9.0000000000000320
Frontiers in immunology IF: 05.900Volume 17, Issue No.79Influences of dietary intake on Chinese women with gestational diabetes mellitus by inhibiting gut microbiome on plasma metabolome膳食摄入通过抑制肠道微生物组对血浆代谢组的影响在中国妊娠期糖尿病女性中的作用DOI: 10.3389/fimmu.2026.1745459
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.80Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes血糖代谢连续谱（空腹血糖/糖化血红蛋白）与泪膜稳定性和分泌的关联：跨越非糖尿病、糖尿病前期和糖尿病的眼表证据DOI: 10.3389/fendo.2026.1788051
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.81Machine learning-based prediction of NAFLD in patients with type 2 diabetes using routine clinical and biochemical indicators基于常规临床和生化指标的机器学习预测2型糖尿病患者非酒精性脂肪性肝病DOI: 10.3389/fendo.2026.1761846
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.82New findings in diabetic kidney disease: correlation and enhanced combined diagnostic value of sclerostin and 25(OH)VD糖尿病肾脏病新发现：硬骨素与25(OH)VD的相关性及联合诊断价值提升DOI: 10.3389/fendo.2026.1817017
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.83The association of serum uric acid with severity and prognosis of patients with diabetic foot ulcers血清尿酸与糖尿病足溃疡患者严重程度及预后的关联DOI: 10.3389/fendo.2026.1732361
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.84Low early-pregnancy serum lipoprotein(a) as an independent associated factor for gestational diabetes mellitus: a retrospective cohort study孕早期血清脂蛋白(a)低水平是妊娠期糖尿病的独立相关因素：一项回顾性队列研究DOI: 10.3389/fendo.2026.1780579
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.85Correction: Multi-feature integrated machine learning prediction model for early nephropathy in elderly living with type 2 diabetes mellitus更正：多特征集成机器学习预测模型用于老年2型糖尿病患者早期肾病DOI: 10.3389/fendo.2026.1807912
Int Med Case Rep J IF: 00.600Volume 19, Issue No.86Ultrasound-Guided Superior Laryngeal Nerve Block Combined with Cricothyroid Membrane Puncture for Awake Tracheal Intubation in a Patient with a Laryngeal Tumor: A Case Report and Literature Review超声引导喉上神经阻滞联合环甲膜穿刺用于喉肿瘤患者清醒气管插管：病例报告与文献综述DOI: 10.2147/IMCRJ.S589800
Frontiers in nutrition IF: 05.100Volume 13, Issue No.87Association between cumulative changes of the C-reactive protein-triglyceride glucose index and the incidence of rapid kidney function decline: a nationwide prospective cohort studyC反应蛋白-甘油三酯葡萄糖指数累积变化与肾功能快速下降发生率的关联：一项全国性前瞻性队列研究DOI: 10.3389/fnut.2026.1795444
Frontiers in nutrition IF: 05.100Volume 13, Issue No.88Structural elucidation and antidiabetic activity of polysaccharides from the parasitic plant Orobanche cumana寄生植物向日葵列当多糖的结构解析与抗糖尿病活性研究DOI: 10.3389/fnut.2026.1785297
Frontiers in nutrition IF: 05.100Volume 13, Issue No.89Microbiota-metabolites interaction associated with glycemic improvement following a dietary herbal intervention in type 2 diabetes2型糖尿病膳食草药干预后与血糖改善相关的微生物群-代谢物相互作用DOI: 10.3389/fnut.2026.1793130
Frontiers in nutrition IF: 05.100Volume 13, Issue No.90New directions in mulberry leaf research for diabetes: a translational approach based on multi-component synergy桑叶糖尿病研究新方向：基于多组分协同的转化策略DOI: 10.3389/fnut.2026.1792767
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.91FGFR1/YAP1 signaling in endothelial cells drives renal fibrosis and offers a therapeutic target内皮细胞中FGFR1/YAP1信号驱动肾脏纤维化并提供治疗靶点DOI: 10.3389/fphar.2026.1766265
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.92Paeoniflorin as a candidate disease-modifying therapy for diabetic peripheral neuropathy: mechanisms, exposure challenges, and translational priorities芍药苷作为糖尿病周围神经病变候选疾病修饰疗法：机制、暴露挑战与转化优先事项DOI: 10.3389/fphar.2026.1751578
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.93Development and Validation of a Nursing-Integrated Nomogram to Predict 1-Year Ulcer Recurrence in Patients with Diabetic Foot Ulcers After Endovascular Therapy整合护理评估的列线图预测糖尿病足溃疡患者血管内治疗后1年溃疡复发的开发与验证DOI: 10.2147/DMSO.S591186
The FASEB journal : IF: 04.200Volume 40, Issue 9No.94The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress ResponseE3连接酶RNF8在肝脏应激反应中促进ChREBPα的泛素化和降解DOI: 10.1096/fj.202600106R
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 3No.95Hypoglycaemia Risk Prediction Models for Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病低血糖风险预测模型的系统评价与荟萃分析DOI: 10.1002/edm2.70227
Journal of diabetes IF: 03.700Volume 18, Issue 5No.96Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes胰腺β细胞功能中的线粒体稳态：糖尿病的机制与治疗靶点DOI: 10.1111/1753-0407.70228
Chinese Medical Journal IF: 07.300Ahead of Print.No.97Molecular mechanisms and novel therapeutic targets of diabetic kidney disease糖尿病肾病的分子机制与新型治疗靶点DOI: 10.1097/CM9.0000000000004025
J Int Med Res IF: 01.500Volume 54, Issue 4No.98Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances1型糖尿病新兴疗法：免疫治疗与基因编辑进展DOI: 10.1177/03000605261440833
J Int Med Res IF: 01.500Volume 54, Issue 4No.99Endothelial activation and stress index links to cardiovascular disease in postmenopausal women mediated by arterial stiffness: A cross-sectional study of National Health and Nutrition Examination Survey 1999-2018内皮激活与应激指数与绝经后女性心血管疾病相关：动脉僵硬度的中介作用——基于1999-2018年美国国家健康与营养调查的横断面研究DOI: 10.1177/03000605261434398
J Int Med Res IF: 01.500Volume 54, Issue 4No.100Effects of probiotic supplementation on glycemic control in children with type 1 diabetes: A systematic review and meta-analysis益生菌补充对1型糖尿病儿童血糖控制的影响：系统评价与荟萃分析DOI: 10.1177/03000605261443077
Frontiers in nutrition IF: 05.100Volume 13, Issue No.101Plant-based caloric restriction diets versus conventional calorie-restricted diets for weight loss and metabolic health in obese adults: a 12-week randomized, open-label, non-inferiority trial植物性热量限制饮食与传统热量限制饮食对肥胖成人减重和代谢健康的影响：一项12周随机、开放标签、非劣效性试验DOI: 10.3389/fnut.2026.1805225
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.102Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis糖尿病视网膜病变与焦虑和抑郁的双向关系：一项荟萃分析DOI: 10.3389/fendo.2026.1764745
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.103Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice二甲双胍和吡格列酮在调节EAE小鼠A1样星形胶质细胞激活中的作用DOI: 10.31083/JIN47364
Frontiers in microbiology IF: 04.500Volume 17, Issue No.104Metformin exacerbates diabetic amyotrophy via oxidative stress and gut microbiota alterations达格列净通过氧化应激和肠道菌群改变加重糖尿病性肌萎缩DOI: 10.3389/fmicb.2026.1778515
Frontiers in immunology IF: 05.900Volume 17, Issue No.105Sheep placental extract ameliorates polycystic ovary syndrome in rats by regulating ERβ-mediated Treg cells via the TGF-β1/Smad3 signaling pathway羊胎盘提取物通过TGF-β1/Smad3信号通路调节ERβ介导的Treg细胞改善大鼠多囊卵巢综合征DOI: 10.3389/fimmu.2026.1777841
Journal of nanobiotechnology IF: 12.600Ahead of Print.No.106Bio-inspired suction cup microneedle loaded fusion membrane targeting nano-drug delivery system treat androgenetic alopecia仿生吸盘微针负载融合膜靶向纳米递药系统治疗雄激素性脱发DOI: 10.1186/s12951-026-04391-5
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.107Quercetin in metabolic diseases: mechanisms, therapeutics, and multidimensional frontiers槲皮素在代谢性疾病中的作用：机制、治疗和多维前沿DOI: 10.3389/fendo.2026.1800322
Frontiers in public health IF: 03.400Volume 14, Issue No.108Dissociation between subjective sleep quality and lipid dysregulation in underground miners: night shift work as an independent risk factor for hypercholesterolemia井下矿工主观睡眠质量与血脂异常的解离：夜班工作是高胆固醇血症的独立危险因素DOI: 10.3389/fpubh.2026.1759787
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.109The DBC1-HIF-1α-PPAR-γ axis regulates Treg cell differentiation to promote myocardial fibrosis in experimental diabetic cardiomyopathy through the paracrine secretion of AregDBC1-HIF-1α-PPAR-γ轴通过旁分泌Areg调节Treg细胞分化促进实验性糖尿病心肌病心肌纤维化DOI: 10.3389/fendo.2026.1780666
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Social science & medicine IF: 05.000Ahead of Print.No.57Using a life table to quantify survival-related selection bias in studies of racial health disparities使用生命表量化种族健康差异研究中的生存相关选择偏倚DOI: 10.1016/j.socscimed.2026.119341
Biosensors & bioelectronics IF: 10.500Ahead of Print.No.58Real-time, label-free impedimetric monitoring of insulin secretion from three-dimensional stem cell-derived islets实时无标记阻抗监测三维干细胞来源胰岛的胰岛素分泌DOI: 10.1016/j.bios.2026.118720
Atención primaria IF: 01.600Ahead of Print.No.59[Effectiveness of telemedicine interventions for the management of gestational diabetes in primary care centers]远程医疗干预在基层医疗中心管理妊娠期糖尿病中的有效性DOI: 10.1016/j.aprim.2026.103504
Diabetes & metabolism IF: 04.700Ahead of Print.No.60Bone phenotype in familial partial lipodystrophy type 2: insulin resistance and sclerostin家族性部分脂肪营养不良2型中的骨表型：胰岛素抵抗与硬骨素DOI: 10.1016/j.diabet.2026.101762
Eye IF: 03.200Ahead of Print.No.61Risk of cerebrovascular and cardiovascular outcomes in patients with an ICD code for ocular migraine眼型偏头痛患者脑血管和心血管结局的风险DOI: 10.1038/s41433-026-04479-0
Scientific reports IF: 03.900Ahead of Print.No.62Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis报销限制降低了安大略省糖尿病成人患者的肝纤维化筛查率：一项基于人群的间断时间序列分析DOI: 10.1038/s41598-026-48600-5
J Diabetes Complications IF: 03.100Ahead of Print.No.63Association between chronic low-grade inflammation and metabolic syndrome and their impact on the risk of coronary artery disease in type 1 diabetes1型糖尿病中慢性低度炎症与代谢综合征的关联及其对冠状动脉疾病风险的影响DOI: 10.1016/j.jdiacomp.2026.109331
BMJ open IF: 02.300Volume 16, Issue 4No.64Prevent 6:1 trial: pI rotocol for a feasibility trial of a 6:1 intermittent diet for weight gain prevention in women at increased risk of breast cancerPrevent 6:1试验：6:1间歇性饮食预防乳腺癌高风险女性体重增加的可行性试验方案DOI: 10.1136/bmjopen-2025-113204
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.65Neuroprotective strategies for cognitive decline in type 2 diabetes2型糖尿病认知衰退的神经保护策略DOI: 10.1016/j.tem.2026.04.003
Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2026, Issue 2No.66Pheochromocytoma and primary hyperparathyroidism: a very rare association in a neurofibromatosis type 1 patient unmasked by Takotsubo syndrome嗜铬细胞瘤与原发性甲状旁腺功能亢进症：Takotsubo综合征揭示的1型神经纤维瘤病患者中极为罕见的关联DOI: 10.1530/EDM-25-0109
Internal medicine IF: 01.100Ahead of Print.No.67Impact of Tirzepatide on FIB-4 in Patients with Type 2 Diabetes: A Comparison between GLP-1RA-naïve and GLP-1RA Switch Initiation in a Retrospective Cohort替尔泊肽对2型糖尿病患者FIB-4的影响：GLP-1RA初治与转换治疗的回顾性队列比较DOI: 10.2169/internalmedicine.6886-25
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.68Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)普瑞巴林与α-硫辛酸联合治疗痛性糖尿病周围神经病变患者的有效性和安全性：一项随机、开放标签、非劣效性、IV期临床试验及亚组分析（OPTIMUM研究）DOI: 10.1111/dom.70795
Domestic animal endocrinology IF: 02.100Ahead of Print.No.69Ertugliflozin decreases the insulin spike in non-insulin dysregulated standardbred horses following intra-articular triamcinolone administration艾托格列净降低非胰岛素调节异常的标准马关节内注射曲安奈德后的胰岛素峰值DOI: 10.1016/j.domaniend.2026.107016
Annals of family medicine IF: 05.100Ahead of Print.No.70Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation专科评估前肌痛性脑脊髓炎/慢性疲劳综合征药物治疗使用不足DOI: 10.1370/afm.250266
Nature IF: 48.500Ahead of Print.No.71A cell atlas charts the immune architecture of diabetic kidney disease细胞图谱揭示糖尿病肾病的免疫结构DOI: 10.1038/d41586-026-01177-5
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.72Cardiovascular–kidney–metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management心血管-肾脏-代谢综合征：病理生理学、流行病学、诊断和管理的全面综述DOI: 10.1186/s12933-026-03177-1
JMIR serious games IF: 04.100Volume 14, Issue No.73User Experience of a Virtual Reality-Based Treadmill for Children With a Chronic Disease Affecting Physical Health: Cross-Sectional Feasibility Study基于虚拟现实的跑步机对患有影响身体健康的慢性疾病儿童的用户体验：横断面可行性研究DOI: 10.2196/82953
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.74U.S. Adolescents of Asian Ethnicity have Higher Risk of Polycystic Ovary Syndrome美国亚裔青少年患多囊卵巢综合征风险更高DOI: 10.1159/000552156
Journal of obesity IF: 03.900Volume 2026, Issue 1No.75Prevalence and Factors Associated With Severe Obesity Among U.S. Adults: A Cross-Sectional Study美国成年人重度肥胖的患病率及相关因素：一项横断面研究DOI: 10.1155/jobe/3831008
JMIR human factors IF: 03.000Volume 13, Issue No.76Continuous Glucose Monitoring for Personalized Nutrition in Real-World Vively App Users: Retrospective Observational Study真实世界Vively应用用户中持续葡萄糖监测用于个性化营养的回顾性观察研究DOI: 10.2196/80734
JMIR human factors IF: 03.000Volume 13, Issue No.77Evaluation of Combined Educational Methods on Motivational Interviewing for Final-Year Medical Students: Mixed Methods Study联合教育方法对医学生动机性访谈能力的影响：混合方法研究DOI: 10.2196/89126
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.78Incidence and Associated Factors of ST-Segment Changes in Noncardiac Surgery Under General Anesthesia全身麻醉下非心脏手术ST段改变的发生率及关联因素DOI: 10.4103/aca.aca_243_25
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.79[Transitional cognitive syndrome: Reconsidered classification of cognitive disorders]过渡性认知综合征：认知障碍分类的再思考DOI: 10.17116/jnevro202612604247
PloS one IF: 02.600Volume 21, Issue 4No.80Catastrophic health care expenditure among older people with non-communicable diseases in 11 European Union Member States11个欧盟成员国患有非传染性疾病的老年人灾难性医疗支出研究DOI: 10.1371/journal.pone.0346341
Einstein IF: 01.100Volume 24, Issue No.81Factors associated with sleep quality and duration in mothers of children with autism spectrum disorder: a cross-sectional study自闭症谱系障碍儿童母亲睡眠质量与时长相关因素：一项横断面研究DOI: 10.31744/einstein_journal/2026AO2004
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.82SGLT2 Inhibitors versus GLP-1 Receptor Agonists Type 2 Diabetes, The Kidney ConundrumSGLT2抑制剂与GLP-1受体激动剂在2型糖尿病中的比较：肾脏难题DOI: 10.2215/CJN.0000001068
Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 4. Vyp. 2No.83[Current evidence-based approaches to the treatment of vascular cognitive impairment]当前血管性认知障碍治疗的循证方法DOI: 10.17116/jnevro202612604278
PloS one IF: 02.600Volume 21, Issue 4No.84Spatial and temporal modeling of breast cancer mortality in Kansas: An R-INLA approach堪萨斯州乳腺癌死亡率时空建模：基于R-INLA方法DOI: 10.1371/journal.pone.0347607
PloS one IF: 02.600Volume 21, Issue 4No.85Implications of acute change in estimated Glomerular Filtration Rate (eGFR) for the effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on long-term endpoints估算肾小球滤过率急性变化对钠-葡萄糖协同转运蛋白2抑制剂长期终点效应的影响DOI: 10.1371/journal.pone.0347741
AIDS IF: 03.100Volume 40, Issue 6No.86SGLT2 inhibitor dapagliflozin attenuates HIV-associated cardiac fibrosis, steatosis and diastolic dysfunction in a mouse model via inhibition of TGFβ signalingSGLT2抑制剂达格列净通过抑制TGFβ信号减轻HIV相关的心脏纤维化、脂肪变性和舒张功能障碍（小鼠模型）DOI: 10.1097/QAD.0000000000004464
The Lancet HIV IF: 13.000Volume 13, Issue 5, Page e287-e356No.87Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trialHIV感染者高血压的发病率、危险因素及心血管影响：REPRIEVE试验的二次分析DOI: 10.1016/S2352-3018(26)00036-6
PloS one IF: 02.600Volume 21, Issue 4No.88Criterion validity and divergent risk profiles of long-term opioid therapy across medicare and medicaid长期阿片类药物治疗在Medicare和Medicaid中的标准效度及风险特征差异DOI: 10.1371/journal.pone.0347943
JMIR research protocols IF: 01.500Volume 15, Issue No.89The Current Landscape of Remote Patient Monitoring Regarding Diabetes Mellitus and Hypoglycemia: Protocol for a Scoping Review远程患者监测在糖尿病和低血糖管理中的现状：范围综述方案DOI: 10.2196/88197
Science advances IF: 12.500Volume 12, Issue 18No.90IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumorsIRS4是一种通过DNA重排或表观遗传机制在多种实体瘤中上调的PI3K激活型癌症依赖性基因DOI: 10.1126/sciadv.aeb3503
Annals of Cardiac Anaesthesia IF: 01.300Ahead of Print.No.91Incidence and Predictors of Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review心脏手术后新发房颤的发生率及预测因素：一项系统综述DOI: 10.4103/aca.aca_285_25
Heart Rhythm IF: 05.700Ahead of Print.No.92Identification of Clinical Risk Factors for Arrhythmia Recurrence in Atrial Fibrillation Patients Undergoing Catheter Ablation: A Systematic review and Meta-analysis房颤导管消融术后心律失常复发的临床危险因素识别：系统评价与荟萃分析DOI: 10.1016/j.hrthm.2026.04.046
Heart IF: 04.400Ahead of Print.No.93Derivation and validation of a prediction model for long-term mortality in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: the PREDICT-ST-Elevation Myocardial Infarction scoreST段抬高型心肌梗死患者经皮冠状动脉介入治疗后长期死亡率预测模型的推导与验证：PREDICT-STEMI评分DOI: 10.1136/heartjnl-2026-327811
Indian Journal of Ophthalmology IF: 01.800Volume 74, Issue 5No.94Biosimilar anti-vascular endothelial growth factor agents: Clinical outcomes, safety, and cost-effectiveness in India生物类似药抗血管内皮生长因子制剂在印度的临床结局、安全性和成本有效性DOI: 10.4103/IJO.IJO_3222_25
JAMA dermatology IF: 11.000Ahead of Print.No.95Deuterated Pentoxifylline Analog in the Treatment of Necrobiosis Lipoidica: A Nonrandomized Clinical Trial氘代己酮可可碱类似物治疗类脂质渐进性坏死：一项非随机临床试验DOI: 10.1001/jamadermatol.2026.0863
Lasers in medical science IF: 02.400Volume 41, Issue 1No.96Photobiomodulation combined with dynamic thermal imaging as a diagnostic tool for chronic leg ulcers光生物调节联合动态热成像作为慢性腿部溃疡的诊断工具DOI: 10.1007/s10103-026-04878-5
Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.97Myeloid transglutaminase 2 regulates Treg-Th17 balance in a female model of Angiotensin II-induced hypertension and vascular stiffening髓系转谷氨酰胺酶2在血管紧张素II诱导的高血压和血管硬化雌性模型中调节Treg-Th17平衡DOI: 10.1152/ajpheart.00095.2026
Journal of fluorescence IF: 03.100Ahead of Print.No.98Design and Optimization of a Glucose Fluorescence Nano-biosensor Based on Graft Copolymer of Poly(acrylic acid)-co-(vinyl phenyl boronic acid)-g-gelatin to Modify CdTe/TGA QDs基于聚丙烯酸-co-乙烯基苯硼酸-g-明胶接枝共聚物修饰CdTe/TGA量子点的葡萄糖荧光纳米生物传感器的设计与优化DOI: 10.1007/s10895-026-04763-y
International ophtalmology IF: 01.400Volume 46, Issue 1No.99Clinical and demographic characteristics of glaucoma patients in Kingston, Jamaica牙买加金斯敦青光眼患者的临床和人口学特征DOI: 10.1007/s10792-026-04020-y
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.100Psychosocial adaptation of parents of children with type 1 diabetes: a cross-sectional study1型糖尿病患儿父母的心理社会适应：一项横断面研究DOI: 10.1515/jpem-2026-0061
J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.101Age and sexual maturation at Spermarche in boys with Laron syndromeLaron综合征男孩首次遗精的年龄与性成熟DOI: 10.1515/jpem-2026-0043
Advances in physiology education IF: 01.700Ahead of Print.No.102The Development and Impact of an Innovative Graduate Program To Promote Entry to Physiology-Related Careers: The Master of Health Science in Medical Physiology创新研究生项目促进生理学相关职业发展的开发与影响：医学生理学健康科学硕士DOI: 10.1152/advan.00060.2026
Diabetes care IF: 16.600Ahead of Print.No.103Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!错误的笔触持续瓦解和摧毁美国生物医学研究：我们不能再容忍自满与恐惧，必须立即行动！DOI: 10.2337/dci26-0068
Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.104Serum Proenkephalin A as a Marker of Renal Dysfunction and Glycemic Status in Diabetic Nephropathy血清前脑啡肽A作为糖尿病肾病肾功能不全和血糖状态的标志物DOI: 10.1177/15578518261444701
Pancreas IF: 01.700Ahead of Print.No.105Predictive Power of Imaging: Assessing Parenchymal Fibrosis in Pediatric Chronic Pancreatitis影像学预测能力：评估儿童慢性胰腺炎实质纤维化DOI: 10.1097/MPA.0000000000002658
Pol Arch Intern Med IF: 04.700Volume 136, Issue 4No.106Corrections: Assessment of the type 2 diabetes risk using the Finnish Diabetes Risk Score questionnaire, and its predictors at the population level in Poland更正：使用芬兰糖尿病风险评分问卷评估2型糖尿病风险及其在波兰人群水平上的预测因素DOI: 10.20452/pamw.17283
Medical care research and review IF: 02.200Ahead of Print.No.107Defining the Social Needs Service Cascade: Evidence From A Multistakeholder Qualitative Study定义社会需求服务级联：来自多利益相关者定性研究的证据DOI: 10.1177/10775587261439173
Global spine journal IF: 03.000Ahead of Print.No.108Incidence and Risk Factors for 30- and 90-day Reoperations Following Biportal Endoscopic Lumbar Discectomy for Single-Level Lumbar Disc Herniations单节段腰椎间盘突出症双通道内镜下椎间盘切除术后30天和90天再手术的发生率及危险因素DOI: 10.1177/21925682261448186
Plast Reconstr Surg IF: 03.400Ahead of Print.No.109Massive Weight Loss with Bariatric Surgery and GLP-1RA Therapy Predicts Postoperative Complications Following Abdominal Body Contouring减重手术与GLP-1RA治疗导致的巨大体重下降预示腹部塑形术后并发症DOI: 10.1097/PRS.0000000000013015
Inflammopharmacology IF: 05.300Ahead of Print.No.110Dapagliflozin mitigates acute pancreatitis induced by L-arginine in Rats through modulation of TLR-4/NF-κB/NLRP3 pathway: integrated biochemical, histopathological, and in silico study达格列净通过调节TLR-4/NF-κB/NLRP3通路减轻L-精氨酸诱导的大鼠急性胰腺炎：整合生化、组织病理学和计算机模拟研究DOI: 10.1007/s10787-026-02190-w
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.111Dapagliflozin ameliorates high-fat diet-induced, megalin-mediated autolysosomal dysfunction in proximal tubules via suppression of megalin-dependent endocytosis达格列净通过抑制megalin依赖性内吞改善高脂饮食诱导的近端肾小管megalin介导的自噬溶酶体功能障碍DOI: 10.1152/ajprenal.00448.2025
Archives of osteoporosis IF: 02.800Volume 21, Issue 1No.112Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density年轻成人炎症性关节炎患者的骨骼健康：低骨密度相关因素的评估DOI: 10.1007/s11657-026-01710-z
JAMA psychiatry IF: 17.100Ahead of Print.No.113Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial司美格鲁肽与重度抑郁症中基于努力的决策：一项随机临床试验DOI: 10.1001/jamapsychiatry.2026.0594
Irish journal of medical science IF: 01.600Ahead of Print.No.114Associations of Mediterranean, DASH, and MIND diet adherence with metabolic parameters in individuals with type 2 diabetes mellitus: a cross-sectional study地中海饮食、DASH饮食和MIND饮食依从性与2型糖尿病患者代谢参数的相关性：一项横断面研究DOI: 10.1007/s11845-026-04415-x
J Egypt Public Health Assoc IF: 02.500Volume 101, Issue 1No.115Psychometric evaluation of the Arabic brief forms of the diabetes distress scale in Egyptian patients with type II diabetes阿拉伯语简短版糖尿病痛苦量表在埃及2型糖尿病患者中的心理测量学评估DOI: 10.1186/s42506-026-00216-3
Retinal cases & brief reportsAhead of Print.No.116Atypical (Three-Quadrant) Central Retinal Vein Occlusion: A Report of two cases and review of literature非典型（三象限）视网膜中央静脉阻塞：两例报告及文献综述DOI: 10.1097/ICB.0000000000001929
Nursing research IF: 02.200Ahead of Print.No.117Perceived Family Support and Treatment Adherence in Older Adults With Type 2 Diabetes老年2型糖尿病患者感知到的家庭支持与治疗依从性DOI: 10.1097/NNR.0000000000000914
Wound repair and regeneration IF: 03.400Volume 34, Issue 3No.118A First-In-Human Study of Pyroligneous Extract, the Biomaterial Derived From Pyrolytic Palm Kernel Shell Wood Vinegar as a Novel Wound Healing Aid on Diabetic Foot Ulcer热解棕榈仁壳木醋液衍生的生物材料——焦木提取物作为糖尿病足溃疡新型伤口愈合辅助剂的首次人体研究DOI: 10.1111/wrr.70166
Multiple sclerosis : IF: 05.000Ahead of Print.No.119Use of semaglutide and tirzepatide among people with multiple sclerosis司美格鲁肽和替尔泊肽在多发性硬化患者中的使用情况DOI: 10.1177/13524585261442033
Food science of animal resources IF: 03.700Volume 44, Issue 1No.120Oral Administration of Lactilactobacillus curvatus LB-P9 Promotes Hair Regeneration in Mice口服弯曲乳杆菌LB-P9促进小鼠毛发再生DOI: 10.5851/kosfa.2023.e74
Clinical transplantation IF: 01.900Volume 40, Issue 5No.121Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation全胰腺切除联合胰岛自体移植后胰岛素独立患者低血糖的发生率及危险因素DOI: 10.1111/ctr.70549
Physiology IF: 10.300Ahead of Print.No.122Multicellular Crosstalk and Therapeutic Vaccines in Heart Failure心力衰竭中的多细胞串扰与治疗性疫苗DOI: 10.1152/physiol.00007.2026
JAMA Network Open IF: 09.700Volume 9, Issue 4No.123Hypertrophic Cardiomyopathy and Risk of Out-of-Hospital Cardiac Arrest肥厚型心肌病与院外心脏骤停风险DOI: 10.1001/jamanetworkopen.2026.9673
Am J Physiol Regul Integr Comp Physiol IF: 02.300Ahead of Print.No.124B-Raf is required for normal murine cardiac development and functionB-Raf对小鼠正常心脏发育和功能是必需的DOI: 10.1152/ajpregu.00063.2025
The Prostate IF: 02.500Ahead of Print.No.125Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications前列腺癌、遗传易感性与慢性非泌尿系统并发症风险DOI: 10.1002/pros.70190
J Eval Clin Pract IF: 02.100Volume 32, Issue 4No.126A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community-Based Diabetic Population: Study Design of the TAMIS Trial远程慢性病管理项目改善多样化社区糖尿病人群心血管和代谢结局：TAMIS试验研究设计DOI: 10.1111/jep.70456
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.127Distinct Antibody Signatures to Human Endogenous Retroviruses and Mycobacterium Paratuberculosis in Newly Diagnosed Tunisian Type 1 Diabetes Patients新诊断突尼斯1型糖尿病患者中人内源性逆转录病毒和副结核分枝杆菌的独特抗体特征DOI: 10.1007/s12013-026-02068-2
Journal of Human Hypertension IF: 03.400Ahead of Print.No.128Consensus on the management of hypertension in individuals with diabetes by Asian-Pacific Society of hypertension (APSH) & Diabetes Asia Study Group (DASG).亚太高血压学会与糖尿病亚洲研究组关于糖尿病患者高血压管理的共识DOI: 10.1038/s41371-026-01150-9
JAMA Cardiology IF: 14.100Ahead of Print.No.129Timeliness of Transthyretin Cardiac Amyloidosis Diagnosis in the Medicare Population医疗保险人群中转甲状腺素蛋白心脏淀粉样变性诊断的及时性DOI: 10.1001/jamacardio.2026.0833
JACC IF: 22.300Ahead of Print.No.130Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions美国医疗系统中8种心血管疾病临床多基因风险报告的开发与验证DOI: 10.1016/j.jacc.2026.03.035
Mol Cell Biochem IF: 03.700Ahead of Print.No.131Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus胎盘炎症升高作为妊娠期糖尿病不良结局的介导因素DOI: 10.1007/s11010-026-05561-7
Irish journal of medical science IF: 01.600Ahead of Print.No.132Reduced fetal MAPSE and TAPSE in gestational diabetes mellitus: a prospective case-control study妊娠期糖尿病胎儿二尖瓣环收缩期位移与三尖瓣环收缩期位移降低：一项前瞻性病例对照研究DOI: 10.1007/s11845-026-04426-8
Soc Psychiatry Psychiatr Epidemiol IF: 03.500Ahead of Print.No.133Association between maternal pregnancy complications and long-term depressive and anxiety disorders: evidence from the UK millennium cohort study母体妊娠并发症与长期抑郁和焦虑障碍的关联：来自英国千禧队列研究的证据DOI: 10.1007/s00127-026-03094-4
JAHA IF: 05.300Ahead of Print.No.134Acute Impact of Transcatheter Edge-to-Edge Repair of Tricuspid Regurgitation on Right Ventricular Hemodynamics经导管缘对缘修复三尖瓣反流对右心室血流动力学的急性影响DOI: 10.1161/JAHA.125.047560
Endokrynologia Polska IF: 02.100Volume 77, Issue 2No.135Eradicating hyperandrogenism? Hormonal changes following Helicobacter pylori eradication in women with polycystic ovary syndrome: an observational case series根除幽门螺杆菌后多囊卵巢综合征女性的激素变化：一项观察性病例系列研究DOI: 10.5603/ep.110428
Saudi pharmaceutical journal IF: 03.400Volume 34, Issue 2No.136Efficacy and safety of pharmacological and procedural interventions in the management of hypertriglyceridemia-induced acute pancreatitis: a systematic review药物和介入干预治疗高甘油三酯血症诱导的急性胰腺炎的有效性和安全性：一项系统评价DOI: 10.1007/s44446-026-00078-y
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.137Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4-Year Follow-Up Cohort StudyCPAP治疗对阻塞性睡眠呼吸暂停合并脂肪性肝病患者肝脏脂肪变性和胰岛素抵抗的有效性：一项4年随访队列研究DOI: 10.1002/kjm2.70222
JAHA IF: 05.300Ahead of Print.No.138Glucose-6-Phosphate Dehydrogenase Modifies the Impact of Glucose on Arterial Aging in A Sex-Specific Manner葡萄糖-6-磷酸脱氢酶以性别特异性方式调节葡萄糖对动脉老化的影响DOI: 10.1161/JAHA.125.045538
JAMA IF: 55.000Ahead of Print.No.139Pigmentary Changes That Developed During Pregnancy妊娠期色素沉着变化DOI: 10.1001/jama.2026.2928
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.140Hypothalamic regulation of energy homeostasis: Quo vadis下丘脑对能量稳态的调控：何去何从DOI: 10.1007/s11154-026-10042-9
Obesity surgery IF: 03.100Ahead of Print.No.141Food Consumption by Processing Levels in Adults Two or More Years After Sleeve Gastrectomy: Associations with Surgical Outcomes and Eating Behaviors袖状胃切除术后两年及以上成年人按加工级别分类的食物消费：与手术结局和饮食行为的关联DOI: 10.1007/s11695-026-08582-9
Cell biochemistry and biophysics IF: 02.500Ahead of Print.No.142Effects of Diet-Induced Obesity and Exercise Intervention on Testicular Germ Cell Health: Modulation of SIRT1/FoxO1 and SIRT1/PGC-1α Signaling Axes饮食诱导肥胖与运动干预对睾丸生殖细胞健康的影响：SIRT1/FoxO1和SIRT1/PGC-1α信号轴的调节DOI: 10.1007/s12013-026-02076-2
BJS open IF: 04.500Volume 10, Issue 2No.143Sleeve gastrectomy versus Roux-en-Y-gastric bypass in patients with body mass index over 50 kg/m2: international multicentre cohort袖状胃切除术与Roux-en-Y胃旁路术在体重指数超过50 kg/m²患者中的比较：国际多中心队列研究DOI: 10.1093/bjsopen/zrag028
J Clin Pharmacol IF: 02.300Volume 66, Issue 5No.144Assessment of the Drug-Drug Interaction Potential of Lotiglipron (PF-07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol评估Lotiglipron（PF-07081532）与咪达唑仑、奥美拉唑、达比加群、瑞舒伐他汀以及口服避孕药左炔诺孕酮和炔雌醇的药物相互作用潜力DOI: 10.1002/jcph.70158
Health informatics journal IF: 02.300Volume 32, Issue 2No.145An informatics-based data-led prioritization strategy to facilitate objective and equitable care for an ethnically diverse urban cohort of people with type 1 diabetes: A proof-of-concept study基于信息学的数据主导优先排序策略：为种族多样化的城市1型糖尿病患者群体提供客观公平护理的概念验证研究DOI: 10.1177/14604582261436276
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.146A scoring system for validity assessment of biomarkers of food intake食物摄入生物标志物有效性评估评分系统DOI: 10.1080/10408398.2026.2633561
Nutrition and health IF: 01.400Ahead of Print.No.147Influence of autonomic function on the thermic effect of food and postprandial insulin sensitivity in individuals with obesity, submitted to a test meal with or without ultra-processed foods: Secondary analysis of a randomized trial自主神经功能对肥胖个体食物热效应和餐后胰岛素敏感性的影响：一项随机试验的二次分析DOI: 10.1177/02601060261446525
Nutrition reviews IF: 04.900Ahead of Print.No.148Methyl Donor Nutrient Intake as a Modulator of the Association between FTO Gene Variants and BMI: A Systematic Review with Meta-Analysis and Meta-Regression甲基供体营养素摄入作为FTO基因变异与体重指数之间关联的调节因素：系统综述、荟萃分析和荟萃回归DOI: 10.1093/nutrit/nuag035
Journal of human lactation : IF: 01.800Ahead of Print.No.149Linking Early Infant Growth With Milk-Derived Antibodies, Hormones, and Macronutrients During Exclusive Breastfeeding纯母乳喂养期间早期婴儿生长与母乳中抗体、激素和宏量营养素的关联DOI: 10.1177/08903344261430138
Open Heart IF: 02.800Volume 13, Issue 1No.150Are clinical improvements in anxiety or depression associated with improvement in walking fitness following a cardiac rehabilitation programme?心脏康复计划后焦虑或抑郁的临床改善是否与步行能力的改善相关？DOI: 10.1136/openhrt-2026-004051
Thyroid research IF: 01.800Volume 19, Issue 1No.151Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE(®) 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study在未经筛选的临床人群中，使用IMMULITE® 2000 TSI检测法测量促甲状腺激素受体抗体优于BRAHMS TRAK检测法，但两者表现均低于预期：一项真实世界回顾性观察研究DOI: 10.1186/s13044-026-00296-5
Int J Reprod Biomed IF: 01.800Volume 24, Issue 2No.152Therapeutic effects of Foeniculum vulgare and Achillea millefolium on ovarian function in a mouse model of polycystic ovary syndrome: An experimental study茴香和蓍草对多囊卵巢综合征小鼠模型卵巢功能的治疗作用：一项实验研究DOI: 10.18502/ijrm.v24i2.21053
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.153Molecular mechanisms of insulin resistance and altered carbohydrate metabolism in PCOS: a scoping review多囊卵巢综合征胰岛素抵抗与碳水化合物代谢改变的分子机制：一项范围综述DOI: 10.3389/fendo.2026.1810805
bioRxivVolume 2026, Issue No.154Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO (2) Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans不同生命阶段中进食状态依赖的CO2趋化可塑性的不同分子机制DOI: 10.64898/2026.02.06.704338
BMC research notes IF: 01.700Ahead of Print.No.155In vitro assessment of the impact of di(2-ethylhexyl) phthalate and its metabolites on the function and transcription of key glucose sensing proteins in a rat pancreatic β-cell line邻苯二甲酸二(2-乙基己基)酯及其代谢物对大鼠胰腺β细胞系关键葡萄糖感应蛋白功能和转录影响的体外评估DOI: 10.1186/s13104-026-07830-6
JACC: AdvancesVolume 5, Issue 5No.156Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock心源性休克患者糖尿病亚型的特征、管理及主要终点DOI: 10.1016/j.jacadv.2026.102766
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.157Prognostic value of advanced imaging biomarkers for the progression of diabetic retinopathy: a systematic review先进影像生物标志物对糖尿病视网膜病变进展的预后价值：一项系统评价DOI: 10.1186/s13098-026-02159-3
Current obesity reports IF: 11.000Volume 15, Issue 1No.158The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights非洲全球共病流行病学：新证据与关键见解DOI: 10.1007/s13679-026-00717-4
Frontiers in health services IF: 02.700Volume 6, Issue No.159Therapeutic intensity and patient-reported outcomes among heart failure patients in a pharmacist-led medication therapy adherence clinic program in Malaysia马来西亚药师主导的药物治疗依从性门诊项目中心力衰竭患者的治疗强度与患者报告结局DOI: 10.3389/frhs.2026.1784432
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.160Acromegalic features and hypoglycemia: Doege-Potter syndrome肢端肥大症特征与低血糖：Doege-Potter综合征DOI: 10.22088/cjim.17.1.205
JCEM case reportsVolume 4, Issue 5No.161A rare case of dual hormone-secreting pulmonary neuroendocrine tumor causing concurrent Cushing syndrome and acromegaly一例罕见的双重激素分泌性肺神经内分泌肿瘤导致库欣综合征和肢端肥大症并存DOI: 10.1210/jcemcr/luag092
Journal of Hypertension IF: 04.100Volume 44, Issue 6No.162Response to letter 'Sex-specific associations between TyG index and emotional states'对《TyG指数与情绪状态的性别特异性关联》一信的回复DOI: 10.1097/HJH.0000000000004289
Int J Eat Disord IF: 04.300Ahead of Print.No.163Sex Differences in Social, Health, and Lifestyle Characteristics Associated With Binge-Eating Behaviors: Results From a French National Random Population-Based Study与暴食行为相关的社会、健康和生活方式特征的性别差异：基于法国全国随机人群研究的结果DOI: 10.1002/eat.70113
J Integr Neurosci IF: 02.700Volume 25, Issue 4No.164Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling脂质比值生物标志物作为新诊断代谢综合征患者抑郁症状的保护因素：来自回归模型的证据DOI: 10.31083/JIN49628
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.165The association between appendicular skeletal muscle index and liver steatosis and fibrosis: A cross-sectional study四肢骨骼肌指数与肝脏脂肪变性和纤维化的关联：一项横断面研究DOI: 10.22088/cjim.17.1.113
Front Sports Act Living IF: 02.600Volume 8, Issue No.166Physiological and cortical determinants of exercise tolerance in sedentary women with obesity久坐肥胖女性运动耐量的生理和皮层决定因素DOI: 10.3389/fspor.2026.1771921
Int J Womens Health IF: 02.600Volume 18, Issue No.167Comparison of Surgical Outcomes Among Open, Laparoscopic, and Robotic Surgeries in Women with Obesity Diagnosed with Endometrial Cancer: Results from a Quaternary Hospital in Thailand肥胖子宫内膜癌患者开腹、腹腔镜与机器人手术结局比较：泰国一家四级医院的结果DOI: 10.2147/IJWH.S598487
JBMR plus IF: 02.400Volume 10, Issue 5No.168Pain medication use in patients with X-linked hypophosphatemia treated with burosumab: a retrospective real-world study布罗索尤单抗治疗X连锁低磷血症患者的止痛药使用：一项回顾性真实世界研究DOI: 10.1093/jbmrpl/ziag047
Journal of affective disorders reportsVolume 24, Issue No.169Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery深度学习模型对减重代谢手术后新发焦虑的洞察DOI: 10.1016/j.jadr.2026.101061
Frontiers in psychology IF: 02.900Volume 17, Issue No.170Didactic adaptation of basketball in physical education to reduce anxiety and emotional eating in adolescent girls with obesity: a randomized controlled trial体育教育中篮球教学适应性改编对肥胖青少年女性焦虑和情绪性进食的影响：一项随机对照试验DOI: 10.3389/fpsyg.2026.1753266
Front Behav Neurosci IF: 02.900Volume 20, Issue No.171Revisiting food addiction in the era of GLP-1-based obesity pharmacotherapy via neural reward pathways linking feeding and substance use在基于GLP-1的肥胖药物治疗时代重新审视食物成瘾：通过连接进食与物质使用的神经奖赏通路DOI: 10.3389/fnbeh.2026.1805953
J Diabetes Investig IF: 03.000Ahead of Print.No.172Validation of the ST1RE risk engine in Chinese with type 1 diabetes and comparison with the JADE, RECODe, and UKPDS risk scoresST1RE风险引擎在中国1型糖尿病患者中的验证及与JADE、RECODe和UKPDS风险评分的比较DOI: 10.1111/jdi.70316
British journal of nutrition IF: 03.000Ahead of Print.No.173Patterns of dietary habits are associated with metabolic health status in adults膳食习惯模式与成人代谢健康状态相关DOI: 10.1017/S0007114526106722
Mol Nutr Food Res IF: 04.200Volume 70, Issue 9No.174Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study母亲时间营养与胎盘DNA甲基化：BiSC研究DOI: 10.1002/mnfr.70465
Lipids IF: 01.600Ahead of Print.No.175Hepatic Lipids as Molecular Targets in Obesity-Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta-Analysis啮齿动物模型中肝脏脂质作为肥胖相关胰岛素抵抗的分子靶点：系统综述与荟萃分析DOI: 10.1002/lipd.70061
J Diabetes Investig IF: 03.000Ahead of Print.No.176Time in range during caloric restriction in type 2 diabetes with obesity肥胖2型糖尿病患者热量限制期间的血糖在目标范围内时间DOI: 10.1111/jdi.70308
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.177Indirect Comparative Efficacy and Safety of Tirzepatide Versus Oral Semaglutide for the Treatment of Overweight and Obesity替尔泊肽与口服司美格鲁肽治疗超重和肥胖的间接比较有效性和安全性DOI: 10.1111/dom.70773
British journal of nutrition IF: 03.000Ahead of Print.No.178Contribution of meals to energy and nutrient intakes and implication of skipping meals on nutritional status among primary schoolchildren in Malaysia马来西亚小学生膳食对能量和营养素摄入的贡献及不吃饭对营养状况的影响DOI: 10.1017/S0007114526107314
J Health Popul Nutr IF: 02.800Ahead of Print.No.179Malnutrition among men in Ghana: socio-demographic factors and rural-urban differences加纳男性营养不良：社会人口因素与城乡差异DOI: 10.1186/s41043-026-01325-7
Allergy IF: 12.000Ahead of Print.No.180Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome食物蛋白诱导性小肠结肠炎综合征患儿肠道和唾液微生物群的纵向随访DOI: 10.1111/all.70363
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.181Potential Application of HIF-PH Inhibitors to Treat Kidney DiseasesHIF-PH抑制剂治疗肾脏疾病的潜在应用DOI: 10.31083/FBL47718
Frontiers in bioscience IF: 03.100Volume 31, Issue 4No.182The Gut-Lung Axis, Epigenetics and Respiratory Disease肠-肺轴、表观遗传学与呼吸系统疾病DOI: 10.31083/FBL48743
Revista de neurología IF: 00.800Volume 81, Issue 4No.183Peripheral Neuropathy: A Phenotype-Driven Review for Diagnosis and Management周围神经病变：基于表型的诊断与管理综述DOI: 10.31083/RN48384
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.184Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran吡非尼酮对重症COVID-19患者肺部CT扫描影响的研究DOI: 10.22088/cjim.17.1.163
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.185Detecting coronary artery disease among the individuals with left-sided dominant coronary circulation左侧优势型冠状动脉循环个体中冠状动脉疾病的检测DOI: 10.22088/cjim.17.1.173
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.186Association of interleukin-8 and neutrophil-to-lymphocyte ratio with clinical indices in diabetic nephropathy白细胞介素-8和中性粒细胞与淋巴细胞比值与糖尿病肾病临床指标的相关性DOI: 10.22088/cjim.17.1.191
Sleep AdvVolume 7, Issue 2No.187Using consumer sleep trackers for sleep extension interventions: retention, adherence, and user experiences使用消费者睡眠追踪器进行睡眠延长干预：保留率、依从性和用户体验DOI: 10.1093/sleepadvances/zpag025
Health science reports IF: 02.100Volume 9, Issue 5No.188How Pre-Pregnancy Weight and Polycystic Ovary Syndrome Impact Pregnancy Outcomes: A Population-Based Cohort Study孕前体重与多囊卵巢综合征对妊娠结局的影响：一项基于人群的队列研究DOI: 10.1002/hsr2.72088
Frontiers in ophthalmologyVolume 6, Issue No.189Use of preoperative swept-source optical coherence tomography in vitrectomy for advanced diabetic eye disease: a pilot study术前扫频源光学相干断层扫描在晚期糖尿病眼病玻璃体切除术中的应用：一项初步研究DOI: 10.3389/fopht.2026.1688660
Clin Med Insights Endocrinol Diabetes IF: 03.000Volume 19, Issue No.190Euthyroid Sick Syndrome Precipitated By Rapid Weight Loss Following Semaglutide Initiation: A Case Report司美格鲁肽治疗后快速减重诱发正常甲状腺病态综合征：一例病例报告DOI: 10.1177/11795514261443862
RSC advances IF: 04.600Volume 16, Issue 24No.191Bacterial metabolite-directed synthesis of biogenic TiO(2)-Zn nanocomposites: characterization and multifunctional biomedical evaluation细菌代谢物导向合成生物源TiO₂-Zn纳米复合材料：表征与多功能生物医学评价DOI: 10.1039/d6ra00881j
Frontiers in chemistry IF: 04.200Volume 14, Issue No.192Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agentsSymphyotrichum squamatum的植物化学谱系及多靶点药理学评价揭示其作为抗糖尿病和抗炎药物来源的潜力DOI: 10.3389/fchem.2026.1734411
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.193Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria哮喘与慢性阻塞性肺疾病重叠（ACO）：基于诊断标准的患病率和共病因素系统综述DOI: 10.1080/20523211.2026.2654490
J Pharm Policy Pract IF: 02.500Volume 19, Issue 1No.194The prevalence and predictor factors of urinary tract infection in type 2 diabetes mellitus patients receiving SGLT2 inhibitors in Qatar: A retrospective cohort study卡塔尔2型糖尿病患者使用SGLT2抑制剂后尿路感染的患病率及预测因素：一项回顾性队列研究DOI: 10.1080/20523211.2026.2645913
Frontiers in public health IF: 03.400Volume 14, Issue No.195Central adiposity outperforms disordered eating behavior in predicting type 2 diabetes risk in young adults: an explainable machine learning approach中心性肥胖在预测年轻人2型糖尿病风险方面优于饮食行为紊乱：一项可解释机器学习方法DOI: 10.3389/fpubh.2026.1778156
Frontiers in public health IF: 03.400Volume 14, Issue No.196Correction: Influence of the COVID-19 pandemic on chronic disease management among indigenous people in Canada更正：COVID-19大流行对加拿大原住民慢性病管理的影响DOI: 10.3389/fpubh.2026.1817733
Int J Microbiol IF: 03.200Volume 2026, Issue No.197Coevolution of Human Diet and Gut Microbiome: Implications for Nutrigenomics and Cross-Population Health人类饮食与肠道微生物组的共同进化：对营养基因组学和跨人群健康的影响DOI: 10.1155/ijm/5597426
Germs IF: 01.700Volume 16, Issue 1No.198Variety of Clostridioides difficile Ribotypes in CDI Patients in Las Vegas, NV内华达州拉斯维加斯CDI患者中艰难梭菌核糖体类型的多样性DOI: 10.3390/germs16010002
Curēus IF: 01.300Volume 18, Issue 3No.199Elevated Lipoprotein(a) and Cardiovascular Outcomes After Percutaneous Coronary Intervention: A Systematic Review经皮冠状动脉介入治疗后脂蛋白(a)升高与心血管结局：一项系统评价DOI: 10.7759/cureus.106009
Curēus IF: 01.300Volume 18, Issue 3No.200Early-Remitting Neonatal Diabetes in a Growth-Restricted Preterm Infant Requiring Insulin: A Case Report生长受限早产儿需胰岛素治疗的早期缓解型新生儿糖尿病：一例病例报告DOI: 10.7759/cureus.106025
Frontiers in physiology IF: 03.400Volume 17, Issue No.201Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition血清素系统调节恢复营养过剩诱导肥胖大鼠脑和心脏的氧化平衡与基因表达DOI: 10.3389/fphys.2026.1783080
Frontiers in medicine IF: 03.000Volume 13, Issue No.202Systemic strategies to prevent early diabetic retinopathy: targeting polyunsaturated fatty acid metabolism and eicosanoid signaling预防早期糖尿病视网膜病变的系统性策略：靶向多不饱和脂肪酸代谢和类花生酸信号DOI: 10.3389/fmed.2026.1802443
J Clin Exp DentVolume 18, Issue 3No.203Nonsurgical Periodontal Therapy for Diabetes Patients with Periodontal Disease非手术牙周治疗对伴有牙周病的糖尿病患者的疗效DOI: 10.4317/jced.63729
J Public Health ResVolume 15, Issue 2No.204Understanding community needs: Comprehensive analysis of the family adoption program conducted in coastal region of South India理解社区需求：印度南部沿海地区家庭收养计划的综合分析DOI: 10.1177/22799036261439972
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.205Relationship between apolipoprotein M levels and diabetic retinopathy in patients with type 2 diabetes mellitus2型糖尿病患者载脂蛋白M水平与糖尿病视网膜病变的关系DOI: 10.3389/fendo.2026.1809680
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.206Dermatologic outcomes associated with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a large-scale target trial emulation胰高血糖素样肽-1受体激动剂与2型糖尿病患者皮肤结局的关联：一项大规模目标试验模拟研究DOI: 10.3389/fendo.2026.1801203
Frontiers in digital health IF: 03.800Volume 8, Issue No.207ChatGPT for diabetes education: potential, accuracy, and accessibility in patient supportChatGPT在糖尿病教育中的应用：患者支持中的潜力、准确性与可及性DOI: 10.3389/fdgth.2026.1768843
bioRxivVolume 2026, Issue No.208Longitudinal in vivo human wound healing model defines key role for smooth muscle cells in ECM remodeling纵向体内人类伤口愈合模型定义平滑肌细胞在细胞外基质重塑中的关键作用DOI: 10.64898/2026.02.24.707845
JCEM case reportsVolume 4, Issue 5No.209Tirzepatide-associated hyponatremia in a patient with known arginine vasopressin deficiency替尔泊肽相关低钠血症在一例已知精氨酸加压素缺乏症患者中的报告DOI: 10.1210/jcemcr/luag110
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.210The therapeutic potential of Vanilla planifolia: how its phytochemicals combat diabetes?香荚兰的治疗潜力：其植物化学物质如何对抗糖尿病？DOI: 10.3389/fphar.2026.1752315
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.211Correction: Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failureα7烟碱型乙酰胆碱受体：靶向炎症、肾素-血管紧张素-醛固酮系统与神经系统之间的相互作用用于心力衰竭的新型治疗DOI: 10.3389/fphar.2026.1841172
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.212The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes嗜铬粒蛋白A裂解产物在1型和2型糖尿病发病中的作用DOI: 10.3389/fcdhc.2026.1812936
Diabetic medicine IF: 03.400Ahead of Print.No.213Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)替普利珠单抗在2型1型糖尿病临床应用的考量：英国儿科内分泌与糖尿病学会和英国临床糖尿病专家协会的共识声明DOI: 10.1111/dme.70329
Diabetic medicine IF: 03.400Ahead of Print.No.214Has the time come for a remission definition in type 1 diabetes? A functional perspective1型糖尿病缓解定义时机已到？功能性视角DOI: 10.1111/dme.70351
Cent Nerv Syst Agents Med ChemAhead of Print.No.215Unveiling the Neuroprotective Role of Nutritional Supplements in Neurodegenerative Diseases揭示营养补充剂在神经退行性疾病中的神经保护作用DOI: 10.2174/0118715249389608251108031453
British journal of nutrition IF: 03.000Ahead of Print.No.216Association between the Mediterranean dietary pattern and Metabolic dysfunction-associated steatotic liver disease (MASLD): A longitudinal analysis from UK BIOBANK地中海饮食模式与代谢功能障碍相关脂肪性肝病的关联：来自英国生物样本库的纵向分析DOI: 10.1017/S0007114526107351
Curr Opin Endocrinol Diabetes Obes IF: 02.700Volume 33, Issue 3No.217Editorial introduction编者按DOI: 10.1097/MED.0000000000000958
Medical decision making : IF: 02.300Ahead of Print.No.218A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data基于微观模拟的慢性肾脏病数据社会偏见缓解方法DOI: 10.1177/0272989X261432162
The journal of dermatology IF: 02.700Ahead of Print.No.219Drug-Induced Blaschkitis Associated With Dipeptidyl Peptidase-4 Inhibitor: A Case Report and Review of the Literature二肽基肽酶-4抑制剂相关药物诱导的Blaschkitis：病例报告及文献综述DOI: 10.1111/1346-8138.70296
Diabetes Technol Ther IF: 06.300Ahead of Print.No.220Safety and Effectiveness of MiniMed™ 780G Advanced Hybrid Closed-Loop Use with Ultrarapid Insulin Lispro-AABC in Pediatric and Adult Type 1 DiabetesMiniMed™ 780G高级混合闭环系统联合超速效胰岛素赖脯-aabc在儿童和成人1型糖尿病患者中的安全性和有效性DOI: 10.1177/15209156261444994
BMC nutrition IF: 02.200Ahead of Print.No.221Dietary advanced glycation end products and risk of cardiometabolic disorders in older adults: cross-sectional data from the 2007-2021 Korea National Health and Nutrition Examination Survey (KNHANES)膳食晚期糖基化终末产物与老年人心脏代谢疾病风险：基于2007-2021年韩国国家健康与营养调查的横断面数据DOI: 10.1186/s40795-026-01334-z
Frontiers in public health IF: 03.400Volume 14, Issue No.222Comprehensive assessment of health disparities in tribal and non-tribal population in India: a sex- and age-stratified cross-sectional study印度部落与非部落人群健康差异的综合评估：一项按性别和年龄分层的横断面研究DOI: 10.3389/fpubh.2026.1772205
Current drug metabolism IF: 01.800Ahead of Print.No.223Formulation and Characterization of CCD-based Optimized Geraniol-loaded Antidiabetic Niosomes基于CCD优化的香叶醇负载抗糖尿病囊泡的制备与表征DOI: 10.2174/0113892002382359251122043509
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.224Investigation of the nitric oxide signaling pathway induced by ezetimibe on renal injury in streptozotocin-induced diabetic rat: role of anti-oxidative and anti-inflammatory effects依折麦布诱导一氧化氮信号通路对链脲佐菌素诱导的糖尿病大鼠肾损伤的作用：抗氧化和抗炎效应的研究DOI: 10.1080/08923973.2026.2657952
Critical care IF: 09.300Volume 30, Issue 1No.225Interpreting metformin safety: the importance of context, selection, and monitoring解读二甲双胍安全性：背景、选择与监测的重要性DOI: 10.1186/s13054-026-06050-5
Curēus IF: 01.300Volume 18, Issue 3No.226THR-β Agonists vs Incretin Therapies for Noncirrhotic Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Biopsy-Anchored Systematic Review With Grading of Recommendations Assessment, Development and Evaluation (GRADE) CertaintyTHR-β激动剂与肠促胰素疗法治疗非肝硬化性代谢功能障碍相关脂肪性肝炎：一项基于活检的系统评价与GRADE证据确定性评估DOI: 10.7759/cureus.106038
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.227Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications单核细胞在HIV相关动脉粥样硬化中的作用：发病机制与临床意义综述DOI: 10.22088/cjim.17.1.1
Caspian J Intern Med IF: 01.000Volume 17, Issue 1No.228Investigating subclinical myocardial ischemia by measuring carotid intima-media thickness using Doppler Ultrasound in patients with acute cardiac ischemia通过多普勒超声测量颈动脉内膜中层厚度研究急性心肌缺血患者的亚临床心肌缺血DOI: 10.22088/cjim.17.1.97
Trials IF: 02.000Ahead of Print.No.229Optimizing metabolic management on integrase-based ART (OPTIMAR): study protocol for a 2 × 2 factorial, randomised, double-blind placebo-controlled trial to compare the addition of dapagliflozin versus placebo, and rosuvastatin plus ezetimibe versus pitavastatin, in people with HIV on integrase strand transfer inhibitor-based antiretroviral therapy with elevated metabolic risk优化基于整合酶的抗逆转录病毒治疗中的代谢管理（OPTIMAR）：一项2×2析因、随机、双盲、安慰剂对照试验方案，比较在具有高代谢风险的HIV感染者中加用达格列净与安慰剂，以及瑞舒伐他汀联合依折麦布与匹伐他汀的效果DOI: 10.1186/s13063-026-09723-2
RSC advances IF: 04.600Volume 16, Issue 24No.230Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis新型哌嗪-三唑杂合物作为PTP1B和α-淀粉酶抑制剂：合成、生物学评价及通过网络药理学、分子对接、MD模拟、DFT和MMPBSA分析的计算验证DOI: 10.1039/d6ra00931j
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.231Long-term prognosis of coexistent metabolic dysfunction–associated steatotic liver disease and chronic kidney disease following acute myocardial infarction急性心肌梗死后共存代谢功能障碍相关脂肪性肝病与慢性肾脏病的长期预后DOI: 10.1007/s00392-026-02925-3
JSCAIAhead of Print.No.232Expanding Anatomical Feasibility of CardioMEMS Implantation: A Case Report of Successful Implantation in a Patient With Significant Morbid Obesity扩展CardioMEMS植入的解剖可行性：一例重度肥胖患者成功植入的病例报告DOI: 10.1016/j.jscai.2026.105319
236
Diabetes Mellitus(DM)
糖尿病
93
Obesity
肥胖症
63
Insulin
胰岛素
27
Type 2 diabetes mellitus(T2DM)
2型糖尿病
14
Metabolic Syndrome
代谢综合征
14
Diabetic Foot
糖尿病足
12
Metformin
二甲双胍
11
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
11
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
11
Diabetic Retinopathy
糖尿病视网膜病
9
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
8
Diabetic Neuropathies
糖尿病性神经病变
7
Semaglutide
司美格鲁肽
7
Hypoglycemic Agents
降糖药
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Tirzepatide
替尔泊肽
5
Diabetes Complications
糖尿病并发症
5
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
4
Pregabalin
普瑞巴林
4
Dapagliflozin
达格列净
2
Ertugliflozin
艾托格列净
2
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
2
Liraglutide
利拉鲁肽
2
Sitagliptin
西他列汀
2
Gabapentin
加巴喷丁
2
Diabetic acidosis
糖尿病性酸中毒
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
Painful Diabetic Peripheral Neuropathy(PDPN)
痛性糖尿病周围神经病变
1
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
1
Canagliflozin
卡格列净
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Vildagliptin
维格列汀
编辑：韩玉莲
审校：韩玉莲
100 项与 洛替格列酮 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 2型糖尿病 | 临床2期 | 美国 | 2022-10-27 | |
| 2型糖尿病 | 临床2期 | 日本 | 2022-10-27 | |
| 2型糖尿病 | 临床2期 | 保加利亚 | 2022-10-27 | |
| 2型糖尿病 | 临床2期 | 加拿大 | 2022-10-27 | |
| 2型糖尿病 | 临床2期 | 捷克 | 2022-10-27 | |
| 2型糖尿病 | 临床2期 | 匈牙利 | 2022-10-27 | |
| 2型糖尿病 | 临床2期 | 波兰 | 2022-10-27 | |
| 肥胖 | 临床2期 | 美国 | 2022-10-27 | |
| 肥胖 | 临床2期 | 日本 | 2022-10-27 | |
| 肥胖 | 临床2期 | 保加利亚 | 2022-10-27 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床1期 | 16 | DE (Period 1: DE 150 mg) | 簾齋淵鹽窪憲鬱築鹽蓋(窪膚餘壓願遞蓋醖遞築) = 鏇製顧簾齋夢選鏇壓壓 衊壓鹽糧顧繭醖構艱簾 (願衊艱廠範鑰蓋鹹憲衊, 43) 更多 | - | 2024-11-15 | ||
DE+PF-07081532 (Period 4: DE 150 mg + PF-07081532 80 mg QD) | 簾齋淵鹽窪憲鬱築鹽蓋(窪膚餘壓願遞蓋醖遞築) = 網醖蓋淵鹹膚夢顧遞蓋 衊壓鹽糧顧繭醖構艱簾 (願衊艱廠範鑰蓋鹹憲衊, 38) 更多 | ||||||
临床1期 | 18 | (Mild Renal Impairment) | 網廠襯遞獵窪願鑰製選(獵鹹襯網餘繭壓構範齋) = 觸糧鑰顧鹽窪衊鹹選窪 憲觸顧獵獵壓鏇鏇鏇製 (鏇憲築醖顧觸鏇鹹繭鏇, 50) 更多 | - | 2024-11-05 | ||
(Moderate Renal Impairment) | 網廠襯遞獵窪願鑰製選(獵鹹襯網餘繭壓構範齋) = 觸網鏇積製糧蓋繭獵積 憲觸顧獵獵壓鏇鏇鏇製 (鏇憲築醖顧觸鏇鹹繭鏇, 24) 更多 | ||||||
临床1期 | - | 6 | (Period 1: [14C]PF-07081532 30 mg Oral) | 鹽壓衊膚夢製衊糧獵築(淵遞艱壓鹽構淵觸範鏇) = 鏇窪選鹽艱網艱淵構膚 製獵願網範簾艱餘觸蓋 (鏇淵夢築衊構窪廠構衊, 0.6) 更多 | - | 2024-09-24 | |
(Period 2: PF-07081532 30 mg Oral + [14C]PF-07081532 100 µg IV) | 壓廠衊選築糧遞選衊憲(鹹淵觸憲衊製壓積糧艱) = 廠鬱艱願觸憲壓窪淵獵 積鹽願構簾繭憲窪艱觸 (淵廠構醖遞艱鹹醖淵觸, 32) 更多 | ||||||
临床1期 | 16 | (Active Comparator: Period 1: Lotiglipron) | 艱餘網襯製齋網襯齋窪(餘網範築齋糧淵蓋構願) = 繭鑰糧憲遞廠鬱糧糧顧 鏇顧窪襯簾醖範衊觸淵 (蓋蓋製齋醖製鏇鹽鹹鏇, 49) 更多 | - | 2024-09-23 | ||
(Experimental: Period 2: Lotiglipron + Cyclosporine) | 艱餘網襯製齋網襯齋窪(餘網範築齋糧淵蓋構願) = 夢願襯選糧鹹遞膚繭築 鏇顧窪襯簾醖範衊觸淵 (蓋蓋製齋醖製鏇鹽鹹鏇, 62) 更多 | ||||||
临床1期 | 24 | (Without Hepatic Impairment) | 蓋鹹醖蓋衊積鏇構淵襯(範鑰獵夢遞襯窪築糧餘) = 遞餘製簾繭糧糧糧觸齋 糧範窪鑰鹽獵範糧廠膚 (齋襯遞廠積膚糧遞鑰鏇, 10) 更多 | - | 2024-08-22 | ||
(Mild Hepatic Impairment) | 蓋鹹醖蓋衊積鏇構淵襯(範鑰獵夢遞襯窪築糧餘) = 膚廠壓淵網範蓋壓繭衊 糧範窪鑰鹽獵範糧廠膚 (齋襯遞廠積膚糧遞鑰鏇, 18) 更多 | ||||||
临床1期 | 34 | Placebo (Placebo (Type 2 Diabetes Mellitus [T2DM])) | 觸獵蓋鬱鹹襯糧齋廠積 = 膚築淵製鹽積鑰鹽膚網 淵遞淵遞鑰憲醖鏇鬱構 (窪鬱齋獵糧夢襯簾廠齋, 獵壓願憲衊簾齋膚鏇淵 ~ 遞壓夢憲範範齋遞窪鏇) 更多 | - | 2024-08-12 | ||
(PF-07081532 20-60 mg (T2DM)) | 觸獵蓋鬱鹹襯糧齋廠積 = 範獵膚願窪鹹壓構網艱 淵遞淵遞鑰憲醖鏇鬱構 (窪鬱齋獵糧夢襯簾廠齋, 夢齋壓鬱構齋夢淵衊鬱 ~ 糧蓋網願憲構鹹膚鑰襯) 更多 | ||||||
临床1期 | 20 | (Formulation A) | 遞廠選鬱窪積衊廠繭鹽(糧蓋鏇觸鹽繭餘鏇艱觸) = 願範憲範構繭獵鹹膚壓 鹽艱鹹壓網糧襯獵鏇製 (顧夢淵憲簾積獵餘遞醖, 40) 更多 | - | 2024-08-09 | ||
(Formulation B) | 遞廠選鬱窪積衊廠繭鹽(糧蓋鏇觸鹽繭餘鏇艱觸) = 齋鏇齋襯鏇構積壓製壓 鹽艱鹹壓網糧襯獵鏇製 (顧夢淵憲簾積獵餘遞醖, 49) 更多 | ||||||
临床1期 | 74 | Lotiglipron 10mg/day | 壓鏇醖糧膚廠壓壓觸構(觸鏇範壓築鏇繭鑰觸願) = Most adverse events were mild (89.6%), with nausea the most frequently reported in both studies. 窪壓顧製網艱餘鹹廠築 (鑰築願獵憲鏇窪蓋獵淵 ) | 积极 | 2024-08-01 | ||
lotiglipron 180-mg (T2D) | |||||||
临床1期 | 66 | Placebo (Placebo Part A) | 鏇夢築鹽願夢醖衊鑰構 = 積鹹範蓋鹹艱構積夢艱 顧淵鹹築鹹窪願遞願鏇 (構壓夢糧膚獵膚齋鬱鹹, 製齋選鏇艱醖醖觸憲艱 ~ 鹽鹹獵憲鏇壓衊夢壓廠) 更多 | - | 2024-02-05 | ||
(PF-07081532 10 mg Part A) | 鏇夢築鹽願夢醖衊鑰構 = 廠選鏇窪鹹獵醖蓋蓋網 顧淵鹹築鹹窪願遞願鏇 (構壓夢糧膚獵膚齋鬱鹹, 選壓鑰壓淵簾簾簾窪顧 ~ 醖憲網窪願顧鏇襯積膚) 更多 | ||||||
临床1期 | - | 糧齋衊鏇積鬱蓋齋憲夢(築窪壓夢選艱廠膚襯窪) = Most adverse events were mild and consistent with the mechanism of action. No clinically significant, adverse trends in laboratory measures, electrocardiogram or vital sign abnormalities were apparent. 積選觸廠構餘觸鏇淵鏇 (顧廠顧蓋繭築積鬱糧醖 ) | 积极 | 2022-09-21 |
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