更新于：2024-11-04
Mivacurium Chloride
米库氯铵
更新于：2024-11-04
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1992-01-22), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C58H80ClN2O14 |
InChIKeyKFWHZSUNFAPZPW-FBIVYNMFSA-M |
CAS号106861-44-3 |
关联
16
项与 米库氯铵 相关的临床试验Effect of mivacurium on tonsillar adenoidectomy in pediatric patients
Evaluation of Effectiveness of Two Different Doses of Mivacurium in Modified Rapid Sequence Intubation for Emergency Surgery ,Prospective Randomized Double Blind Study
Comparison of continuous infusion of two doses of mivacurium during laryngeal microsurgery under general anesthesia:a prospective, randomized, controlled, double-blind clinical trial
100 项与 米库氯铵 相关的临床结果
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100 项与 米库氯铵 相关的转化医学
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100 项与 米库氯铵 相关的专利（医药）
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726
项与 米库氯铵 相关的文献（医药）2024-10-04MEDICINE
A novel BCHE frameshift mutation in a Chinese woman with butyrylcholinesterase deficiency: A case report and literature review
Review
作者: Zeng, Jiantao ; Yang, Dan ; Zheng, Zhaobin ; Xia, Jun ; Dai, Tao
Rationale::
Congenital butyrylcholinesterase deficiency (BCHED) is a rare autosomal recessive genetic disorder caused by a pathogenic mutation in the BCHE gene. Patients with BCHED may experience prolonged apnea or even death after the application of drugs such as succinylcholine. We aimed to identify the genetic basis of disease in a patient presenting with butyrylcholinesterase deficiency in order to confirm the diagnosis, expand BCHE gene mutation spectrum, and elucidate potential genotype-phenotype associations to inform management.
Patient concerns::
A 51-year-old woman presented with “vague pain in the upper and middle abdomen.” Her serum cholinesterase level was 211 U/L (reference value 4000–13,000 U/L). Other laboratory findings were normal. Genetic analysis revealed compound heterozygous mutations in BCHE gene, which was considered pathogenic in this case.
Diagnoses::
The patient presented with low serum cholinesterase levels, which excluded common causes such as liver disease, drug toxicity, and chronic illness. Whole exon examination revealed compound heterozygous mutations in the BCHE gene; thus, the patient was diagnosed with congenital BCHED.
Interventions::
Gastroscopy without succinylcholine or mivacurium chloride was recommended. The gastroscopy results were “gastric polyps,” and gastroscopic “polypectomy” was performed. The patient was advised to avoid succinylcholine use.
Outcomes::
The patient’s serum cholinesterase level was reviewed 3 months later, and the result was 215 U/L. Double heterozygous mutations are the cause of BChE deficiency of this woman in this study, including a novel mutation NM_000055.4: c.666_669del (p.Phe223Glufs*38). A review of the literature reveals considerable variation in the hotspot variants of the BCHE gene across different populations. The Chinese population displays a higher prevalence of the silent type, which is more sensitive to anesthetics such as succinylcholine.
Lessons::
Clinical manifestations of congenital BCHED were not significant. This study avoided a potential anesthetic accident, and the novel variant enriched the BCHE gene mutation spectrum.
2024-08-01ACTA ANAESTHESIOLOGICA SCANDINAVICA
Onset time, duration of action, and intubating conditions after mivacurium in elderly and younger patients
Article
作者: Rosager, Christine L. ; Dalsten, Helene ; Wadland, Sarah Sofie ; Kempff‐Andersen, Sebastian ; Creutzburg, Andreas ; Rasmussen, Lars S. ; Rosenkrantz, Oscar ; Vested, Matias
Abstract:
Background:
The neuromuscular blocking agent mivacurium can be used during anesthesia to facilitate tracheal intubation. Data on onset time, duration of action, and effect on intubating conditions in patients 80 years and older are however limited. We hypothesized that onset time and duration of action of mivacurium would be longer in elderly patients than in younger adults.
Methods:
This prospective observational study included 35 elderly (≥80 years) and 35 younger (18–40 years) patients. Induction of anesthesia comprised fentanyl 1–3 μg kg−1 and propofol 1.5–2.5 mg kg−1 and propofol and remifentanil for maintenance. Acceleromyography was used for monitoring neuromuscular blockade. The primary outcome was onset time defined as time from injection of mivacurium 0.2 mg kg−1 to a train‐of‐four (TOF) count of zero. Other outcomes included duration of action (time to TOF ratio ≥0.9), intubating conditions using the Fuchs‐Buder scale and the intubating difficulty scale (IDS), and occurrence of hoarseness and sore throat postoperatively.
Results:
No difference was found in onset time comparing elderly with younger patients; 219 s (SD 45) versus 203 s (SD 74) (difference: 16 s (95% CI: −45 to 14), p = .30). Duration of action was significantly longer in elderly patients compared with younger patients; 52 min (SD 17) versus 30 min (SD 8) (difference: 22 min [95% CI: 15 to 28], p < .001). No difference was found in the proportion of excellent intubating conditions (Fuchs‐Buder); 31/35 (89%) versus 26/35 (74%) (p = .12) or IDS score (p = .13). A larger proportion of younger patients reported sore throat 24 h postoperatively; 34% versus 0%, p = .0002. No difference was found in hoarseness.
Conclusion:
No difference in onset time of mivacurium 0.2 mg kg−1 was found comparing elderly and younger patients. However, elderly patients had significantly longer duration of action. No difference was found in intubating conditions.
2024-08-01BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Design, synthesis, and biological evaluation of new bis-benzylisoquinoline-based analogues as potential neuromuscular blocking agents
Article
作者: Song, Hao ; Chen, Chen ; Fu, Lin ; Ke, Bowen ; Liu, Xiaofeng ; Chen, Gang ; Qin, Yong ; Zhao, Yi ; Gan, Yu
Neuromuscular blocking agents (NMBAs) are widely used in anesthesia for intubation and surgical muscle relaxation. Novel atracurium and mivacurium derivatives were developed, with compounds 18c, 18d, and 29a showing mivacurium-like relaxation at 27.27 nmol/kg, and 15b, 15c, 15e, and 15h having a shorter duration at 272.7 nmol/kg. The structure-activity and configuration-activity relationships of these derivatives and 29a's binding to nicotinic acetylcholine receptors were analyzed through molecular docking. Rabbit trials showed 29a has a shorter duration compared to mivacurium. This suggests that linker properties, ammonium group substituents, and configuration are crucial for NMBA activity and duration, with compound 29a emerging as a potential ultra-short-acting NMBA.
100 项与 米库氯铵 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 妊娠剧吐 | 中国 | 2005-08-11 | |
| 麻醉 | 美国 | 1992-01-22 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 24 | (Moderate/Normal Surgical Block) | 獵窪廠壓壓夢獵選網糧(齋簾選醖範鹽繭糧顧築) = 餘窪遞膚夢鑰艱膚壓夢 壓遞簾顧齋餘衊壓壓鑰 (築鬱獵積網網繭獵夢鏇, 繭範鹽願願淵餘網觸憲 ~ 顧衊醖淵觸獵構衊鬱餘) 更多 | - | 2016-10-17 | ||
(Deep Surgical Block) | 獵窪廠壓壓夢獵選網糧(齋簾選醖範鹽繭糧顧築) = 鬱鬱鹹糧廠窪糧鑰淵鹹 壓遞簾顧齋餘衊壓壓鑰 (築鬱獵積網網繭獵夢鏇, 選蓋醖製醖鹽齋餘蓋窪 ~ 鹽蓋齋糧範製網獵鹹觸) 更多 | ||||||
N/A | - | - | Mivacurium 50 microg/kg | 襯簾餘蓋窪範築築蓋糧(壓鹽憲夢鹽願醖獵鏇憲) = 積憲醖簾獵鑰襯網襯願 遞齋積淵願鏇遞糧衊觸 (鏇鹹積憲選襯蓋餘鬱糧, 82 ~ 127) 更多 | - | 2001-12-01 | |
Mivacurium 100 microg/kg | 襯簾餘蓋窪範築築蓋糧(壓鹽憲夢鹽願醖獵鏇憲) = 廠鹹鏇構獵簾醖鏇選觸 遞齋積淵願鏇遞糧衊觸 (鏇鹹積憲選襯蓋餘鬱糧, 51 ~ 82) 更多 |
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