预约演示
更新于：2026-02-27
Potassium Phosphate, Dibasic/Potassium Phosphate, Monobasic
磷酸二氢钾/磷酸氢二钾
更新于：2026-02-27
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2019-09-19), |
最高研发阶段(中国)- |
特殊审评- |
登录后查看时间轴
结构/序列
分子式H3K2O4P |
InChIKeyNRCOWFOUENSLID-UHFFFAOYSA-N |
CAS号7758-11-4 |
查看全部结构式(2)
关联
2
项与 磷酸二氢钾/磷酸氢二钾 相关的临床试验EUCTR2018-003596-36-GB
A single centre, open label Randomised Controlled Trial of the RAPID™* PRP (Platelet Rich Plasma) Haematogel Wound Care Treatment in addition to Usual and Customary Care, (UCC); compared to Usual and Customary Care (UCC) alone, in the management of adult patients with chronic Diabetic Foot Ulcers. RAPID™* [Restorative Autologous Platelet biotherapies for treatment of Injuries & Delayed wound healing] Biodynamic Platelet Rich Plasma [PRP] Haematogel
NCT00919633
COPE-HCV: Continuous Interferon Delivery Via the Medtronic Paradigm Pump Infusion System Clinical Evaluation for Chronic HCV
100 项与 磷酸二氢钾/磷酸氢二钾 相关的临床结果
登录后查看更多信息
100 项与 磷酸二氢钾/磷酸氢二钾 相关的转化医学
登录后查看更多信息
100 项与 磷酸二氢钾/磷酸氢二钾 相关的专利（医药）
登录后查看更多信息
32
项与 磷酸二氢钾/磷酸氢二钾 相关的文献（医药）2026-01-01JOURNAL OF DAIRY SCIENCE
Supplementation of rumen-protected microalgae high in docosahexaenoic acid to lactating dairy cows under heat stress: Effects on performance, digestibility, and health
Article
作者: Luo, Jia-Zhi ; He, Bing ; Mao, Sheng-Yong ; Shen, Jun-Shi ; Zhang, Han ; Duan, Hong-Wei ; Xiao, Zhuohang ; Ye, Heng-Bo ; Zhang, Ji-You ; Liu, Ze-Yu ; Zhu, Wei-Yun
This study evaluated the effects of rumen-protected Schizochytrium powder on physiological responses, antioxidant capacity, and lactation performance in dairy cows subjected to heat stress (HS). A total of 30 Holstein dairy cows in mid-lactation (181 ± 32 DIM; 29.0 ± 3.1 kg milk yield) were divided into 2 blocks based on milk yield and were then randomly assigned to 1 of 3 groups (n = 10 cows per group): a control group (CON), an uncoated Schizochytrium powder (USP) group, and a coated Schizochytrium powder (CSP) group. The experiment comprised a 14-d adaptation, 21-d treatment, and 7-d washout period. Temperature-humidity index (THI) values ranged from 72.54 to 86.90 (average: 78.44), indicating conditions of mild to moderate HS. Under these conditions, no significant treatment × time interaction effects were observed for rectal temperature (RT) and respiratory rate (RR), but significant differences among treatments were detected. The CSP group exhibited significantly lower RR (50.71 breaths/min) and RT (38.91°C) compared with the CON group (RR: 61.58 breaths/min; RT: 39.19°C), and the USP group (RR: 62.70 breaths/min; RT: 39.30°C). A significant interaction between treatment and time was observed for milk fat concentration. Specifically, during wk 2, the milk fat concentration in the CSP group was lower compared with the CON and USP groups, whereas no differences were detected among the groups in wk 3. No significant treatment × time interaction was found for milk yield and feed efficiency; however, cows in the CSP group exhibited higher milk yield and feed efficiency than those in the CON and USP groups. The CSP group exhibited higher digestibility than the CON and USP groups, with DM increased by 3.9% to 4.5%, OM by 3.8% to 4.4%, CP by 5.2%, NDF by 18.2% to 25.8%, and ADF by 14.6% to 22.8%. Plasma levels of IgG, IgM, glutathione peroxidase (GSH-Px), and heat shock protein 70 (HSP70) exhibited significant treatment × time interactions. On d 14, plasma IgG and IgM levels were higher in the CSP and CON groups than in the USP group. By d 21, plasma IgG levels were highest in the CSP group, intermediate in the USP group, and lowest in the CON group. Plasma GSH-Px activity was increased and HSP70 decreased in CSP cows at both sampling points. No treatment × time interaction was observed for plasma superoxide dismutase (SOD) or catalase (CAT) activities. Nevertheless, SOD activity was significantly elevated in the CSP group compared with the CON group, and CAT activity was increased in both the CSP and USP groups relative to the CON group. Overall, supplementation with CSP resulted in reduced RR and RT and enhanced antioxidant status, and was associated with increased milk yield and nutrient digestibility in dairy cows experiencing HS.
2026-01-01JOURNAL OF DAIRY SCIENCE
Supplementation of rumen-protected microalgae high in docosahexaenoic acid to lactating dairy cows: Dynamics of lactation performance, milk and plasma fatty acids, and transfer rate of docosahexaenoic acid to milk
Article
作者: Luo, Jia-Zhi ; Mao, Sheng-Yong ; Zhang, Han ; Shen, Jun-Shi ; Ren, Da-Xi ; He, Bing ; Duan, Hong-Wei ; Erdene, Khas ; Ye, Heng-Bo ; Zhu, Wei-Yun ; Liu, Ze-Yu ; Zhang, Ji-You
This study evaluated the effects of rumen-protected Schizochytrium powder (SP) on dynamics of lactation performance, plasma and milk fatty acids (FA) profiles, and transfer rate of DHA to milk in dairy cows. A total of 30 Holstein cows (181 ± 32 DIM; 29.0 ± 3.1 kg milk yield) were divided into 2 blocks based on milk yield and were then randomly assigned to 1 of 3 groups (n = 10 cows per group): a control group (CON), an uncoated SP group (USP), and a coated SP group (CSP). The experiment comprised a 14-d adaptation phase, 21-d treatment phase, and 7-d washout period. The SP supplementation did not affect milk yield but showed a significant treatment × time interaction for milk fat concentration. The CSP showed reduced milk fat concentration on d 7 and 14 compared with CON and USP, but recovered to comparable levels by d 21. Based on principal coordinate analysis, significant variations in plasma FA profiles were identified among the 3 groups. A treatment × time interaction was detected for plasma docosahexaenoic acid (DHA) and n-3 PUFA concentrations. On d 14, CSP exhibited elevated plasma DHA and n-3 PUFA levels compared with CON and USP. On d 21, plasma DHA levels were higher in CSP than in USP, and higher in USP than in CON. Furthermore, on d 21, plasma n-3 PUFA levels in both CSP and USP were higher than those in CON. A treatment × time interaction was observed for milk DHA concentration, DHA excretion via milk, and DHA transfer rate. From d 1 to 7, CSP showed higher DHA concentration and DHA excretion via milk compared with USP. From d 14 to 28, CSP consistently maintained higher DHA concentration and excretion via milk than USP, which in turn exceeded the levels observed in CON. Following the cessation of supplementation, DHA levels exhibited a gradual decline over a 7-d period; however, CSP group retained comparatively high levels. Throughout the 0- to 21-d feeding interval, the milk DHA transfer rate demonstrated a continuous increase in both CSP and USP, with CSP consistently outperforming USP. On d 21, both DHA concentration and transfer rate attained their maximum values in cows supplemented with CSP and USP, with DHA transfer rate recorded at 11.82% and 2.36%, respectively. In summary, SP can be effectively used as a dietary supplement in dairy cows to optimize the milk FA profile and increase DHA content, with CSP exhibiting superior efficacy relative to USP.
2025-07-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Insight into the changes in structural, physicochemical, and probiotic properties of yam peel polysaccharides subjected to different physical-assisted extraction methods
Article
作者: Yu, Yuanshan ; Cheng, Lina ; Chang, Hong ; Peng, Jian ; Li, Lu ; Duan, Zhenhua ; Xu, Yujuan ; Lu, Jinghui ; Li, Dingjin
In the present study, Chinese yam peel polysaccharides (CYPPs) were extracted using hot water (HWP) and six physical-assisted methods: ultrasound (USP), high hydrostatic pressure (HHPP), pulsed electric field (PEFP), cold plasma (CPP), microwave (MWP), and radio frequency (RFP). Their structural, physicochemical, and biological properties were compared. The physical-assisted methods significantly influenced the yields, monosaccharide constituent ratios, molecular weight (Mw), conformation, surface morphology, and antioxidant and probiotic activities of these CYPPs. Glucose was identified as the most abundant monosaccharide, with contents ranging from 482.42 to 531.51 mg/g across all CYPPs. MWP achieved the highest extraction yield (15.52 ± 0.20 %), molecular weight (353.35 kDa) and vertical distances (1.66-2.54 nm). USP and HHPP exhibited a leaf vein micromorphology characterized by a stem-like center. The thermal stability of CYPPs can be enhanced by physical-assisted methods and all CYPPs possessed typical polysaccharides absorption and an amorphous state. Furthermore, USP and HHPP displayed comparatively higher antioxidant capacity and probiotic growth activity than the other CYPPs. The findings offer alternative methods for polysaccharide extraction and provide foundational characteristics for development and utilization of polysaccharides derived from Chinese yam peels.
100 项与 磷酸二氢钾/磷酸氢二钾 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 低磷血症 | 美国 | 2019-09-19 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 116 | (Group 4: Peginterferon Alfa-2b (1.5 μg/kg)) | 鬱襯齋鬱網艱網鹽齋鏇 = 獵簾鬱憲鑰繭鑰遞醖鹹 積鏇憲鏇襯願窪獵憲糧 (餘願廠膚糧獵鬱觸糧築, 鑰築衊膚繭衊鬱襯蓋鏇 ~ 艱鹽膚鏇鏇糧鹽蓋願壓) 更多 | - | 2014-04-30 | ||
(Group 1: Interferon Alfa-2b (Dose 1)) | 鬱襯齋鬱網艱網鹽齋鏇 = 鬱艱蓋蓋膚糧網選顧壓 積鏇憲鏇襯願窪獵憲糧 (餘願廠膚糧獵鬱觸糧築, 繭願遞醖廠餘廠顧獵壓 ~ 鹹齋齋鑰壓構築積夢顧) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用