Peginterferon alfa-2b(Merck & Co)

高纯度PEG衍生物及聚乙二醇化修饰：科研与工业领域的核心材料在药物递送、生物医药及材料科学领域，高纯度PEG衍生物及聚乙二醇化修饰技术已成为推动行业创新的关键力量。据统计，全球生物医药市场规模已突破5000亿美元，其中药物递送系统占比超过20%，而PEG衍生物作为核心载体材料，其市场需求正以年均8%的速度增长。聚乙二醇化修饰技术通过改善药物溶解性、稳定性及生物相容性，显著提升了药物的疗效与安全性，成为现代医药研发中不可或缺的一环。高纯度PEG衍生物的技术特点与优势高纯度PEG衍生物，如mPEG-bALD、mPEG-MAL、mPEG-NH2等，以其独特的化学结构与功能特性，在科研与工业领域展现出显著优势。mPEG-bALD（甲氧基聚乙二醇-丁醛）通过醛基与蛋白质或肽的氨基反应，实现高效共价结合，广泛应用于药物载体与生物标记物的制备。mPEG-MAL（甲氧基聚乙二醇-马来酰亚胺）则利用马来酰亚胺基团与巯基的特异性反应，实现靶向修饰，显著提升药物的靶向性与生物利用度。mPEG-NH2（甲氧基聚乙二醇-氨基）作为基础衍生物，通过氨基与羧基、活性酯等基团的反应，构建多样化的药物递送系统，满足不同科研需求。聚乙二醇化修饰技术的核心优势在于其能够显著改善药物的物理化学性质。例如，通过修饰后的药物分子量增加，溶解性提升，从而减少注射剂量与频率；同时，修饰后的药物在血液中的半衰期延长，药效持续时间更久。据研究，经聚乙二醇化修饰的干扰素α-2b，其半衰期从6.7小时延长至40小时，药效提升近6倍，显著降低了患者的用药负担。polydarwin平台：科研试剂智能供应的**者Polydarwin平台作为一个科研试剂智能供应平台，致力于为药物递送、生物医药及材料科学等领域提供高效且便捷的一站式采购体验。平台涵盖药物递送载体、原辅料、荧光染料及医用新材料等优质产品，其中高纯度PEG衍生物及聚乙二醇化修饰产品是其核心产品线之一。polydarwin平台通过数字化服务，消除传统采购的繁琐流程，支持用户全程在线自主选品、下单、支付，并跟进订单进度，显著节省科研时间。据平台数据统计，用户平均采购周期缩短至3天以内，较传统模式提升效率超过60%。平台建立了严格的产品质量控制体系，确保所有产品符合科研实验的高标准要求。高纯度PEG衍生物的纯度均达到99%以上，批次间稳定性差异小于1%，为科研结果的可靠性提供了坚实保障。同时，polydarwin平台拥有一支由领域内专家组成的技术团队，能够为用户提供丰富的产品选择与稳定的供货保障。无论是基础研究还是应用开发，用户均可获得专业的技术支持与定制化解决方案。polydarwin平台主营产品深度解析polydarwin平台的主营产品涵盖高纯度PEG衍生物及聚乙二醇化修饰的多个细分领域。mPEG-bALD作为平台明星产品之一，其醛基含量高达95%以上，反应活性强，适用于多种蛋白质与肽的修饰。在药物递送系统中，mPEG-bALD修饰的脂质体纳米粒能够显著延长药物在血液中的循环时间，提升肿瘤靶向性，降低全身毒性。据临床前研究数据，经mPEG-bALD修饰的紫杉醇脂质体，其肿瘤抑制率较未修饰组提升40%，显示出巨大的应用潜力。mPEG-MAL则是平台另一款热销产品，其马来酰亚胺基团含量稳定，反应条件温和，适用于巯基化合物的靶向修饰。在抗体药物偶联物（ADC）的研发中，mPEG-MAL作为连接子，能够精准地将细胞毒性药物与抗体结合，实现肿瘤细胞的特异性杀伤。据统计，全球已有超过20款ADC药物进入临床试验阶段，其中超过半数采用聚乙二醇化修饰技术，mPEG-MAL的市场需求持续增长。mPEG-NH2作为基础衍生物，其应用范围更为广泛。通过氨基与羧基、活性酯等基团的反应，mPEG-NH2能够构建多样化的药物递送系统，如聚乙二醇化蛋白质、聚乙二醇化脂质体及聚乙二醇化纳米粒等。在疫苗研发中，mPEG-NH2修饰的抗原能够显著提升免疫原性，增强疫苗的保护效果。据研究，经mPEG-NH2修饰的流感疫苗，其抗体滴度较未修饰组提升2倍以上，显示出良好的应用前景。polydarwin平台在行业内的知名度与影响力在行业内有较高知名度的polydarwin平台，凭借其优质的产品与专业的服务，赢得了广大科研人员的信赖与好评。平台与全球多家知名科研机构及制药企业建立了长期合作关系，累计服务客户超过1000家，覆盖药物递送、生物医药、材料科学等多个领域。据用户反馈，polydarwin平台的产品质量稳定可靠，技术支持专业及时，为科研项目的顺利推进提供了有力保障。平台还积极参与行业交流与学术研讨，定期举办线上线下的技术讲座与培训活动，分享*新的科研成果与应用案例。通过与行业专家的深入交流，polydarwin平台不断优化产品结构与服务流程，提升用户体验与满意度。据平台调查数据，用户对polydarwin平台的整体满意度达到95%以上，其中产品质量与技术支持的满意度均超过98%。结语：选择polydarwin平台，开启科研新篇章高纯度PEG衍生物及聚乙二醇化修饰技术作为现代科研与工业领域的核心材料，其重要性不言而喻。polydarwin平台凭借其丰富的产品线、严格的质量控制体系及专业的技术支持团队，为用户提供了高效、便捷、可靠的一站式采购体验。无论是基础研究还是应用开发，选择polydarwin平台，均能够获得优质的产品与专业的服务，助力科研项目的顺利推进与成果转化。在未来的发展中，polydarwin平台将继续秉承“创新、专业、服务”的理念，为药物递送、生物医药及材料科学等领域的发展贡献更多力量。返回搜狐，查看更多

- Announced Positive Data from Phase 1 Dose Expansion Study of varsetatug masetecan (“Varseta-M”) EpCAM PROBODY ® ADC in Patients with Advanced Colorectal Cancer (CRC) - - FDA interactions targeted for mid-year with goal to align on potential Varseta-M registrational trial design in late line CRC - - Varseta-M Phase 1 study evaluating combination with bevacizumab initiated; Phase 1b/2 chemotherapy combination study to be initiated by the end of 2026 - - Initial CX-801 PROBODY Interferon-alpha-2b Phase 1 combination data with KEYTRUDA ® (pembrolizumab) in melanoma expected by the end of 2026 - - Company to host conference call today at 8 a.m. ET / 5 a.m. PT - SOUTH SAN FRANCISCO, Calif., March 16, 2026 (GLOBE NEWSWIRE) -- CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced 2025 financial results and provided a business update. “Today’s encouraging Varseta-M Phase 1 update underscores the program’s intentional design and broad potential in CRC as well as other EpCAM-expressing indications. CytomX’s top priority in 2026 is to align with the FDA on a registrational path for Varseta-M in late-line CRC. We also plan to accelerate Varseta-M combination studies to benefit CRC patients in earlier lines of treatment,” said Sean McCarthy, D.Phil., chief executive officer and chairman of CytomX. “Our continued and exciting progress with Varseta-M reinforces our leadership in the field of masking and CytomX’s ability to unlock true innovation. Our highly focused portfolio strategy is also illustrated by our second clinical program, CX-801. This masked version of Interferon-alpha-2b is being developed initially in advanced melanoma and, we believe, has the potential to become a new centerpiece of combination immunotherapy across multiple cancers. The CX-801 translational and biomarker data presented to date have been very encouraging, and we expect to share initial proof of concept data for the combination with KEYTRUDA ® later this year.” Pipeline Program Updates: Varsetatug masetecan (EpCAM PROBODY Topo-1 ADC, CX-2051) Announced positive data update from Phase 1 dose expansion study of Varseta-M in patients with advanced colorectal cancer (CRC). The Company aims to align with the FDA in 2026 on a potential registrational study design for Varseta-M monotherapy in advanced CRC. Additional Phase 1 follow-up data are also expected to be presented at major medical meeting(s) in 2026. A Phase 1 Varseta-M combination study with bevacizumab in CRC has been initiated and a Phase 1b/2 study in combination with bevacizumab and chemotherapy is expected to start by the end of 2026. Initiation of Phase 1 expansion cohort(s) in additional indications is planned for 2H 2026. CX-801 (PROBODY Interferon alpha-2b) The CX-801 Phase 1 study is progressing with a focus in advanced melanoma. The CX-801 monotherapy dose escalation portion of the study has reached the fourth dose level. CX-801 monotherapy has been well tolerated at dose levels exceeding the approved dose of unmasked IFNα2b. 1 In May 2025, Phase 1 dose escalation of CX-801 in combination with KEYTRUDA ® (pembrolizumab) was initiated. Dose escalation of CX-801 in combination with KEYTRUDA ® is currently enrolling the 2 nd dose level. Biomarker data from the CX‑801 monotherapy study in advanced melanoma were presented at the 2025 Society for Immunotherapy of Cancer (SITC) Annual Meeting, reinforcing CX‑801’s mechanism of action and supporting the ongoing combination trial with KEYTRUDA ® . Initial clinical data for CX-801 in combination with KEYTRUDA ® in advanced melanoma is projected by the end of 2026. KEYTRUDA ® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA Corporate and Financial: Financial: CytomX ended 2025 with $137.1 million of cash, cash equivalents and investments with expected cash runway to the second quarter of 2027. Research Pipeline and Collaborations : CytomX has research collaborations with Bristol Myers Squibb, Amgen, Regeneron, and Moderna. Multiple drug discovery programs continue across our research collaborations with a focus on bispecific immunotherapies, including T-cell engagers. In March 2026, Astellas chose to not advance the remaining preclinical research programs under the alliance resulting in a termination of the collaboration effective in the second quarter of 2026. Full Year 2025 Financial Results: Cash, cash equivalents and investments totaled $137.1 million as of December 31, 2025, compared to $100.6 million as of December 31, 2024. Total revenue was $76.2 million for the year ended December 31, 2025, compared to $138.1 million in 2024. The decrease in revenue was driven primarily by the completion of our performance obligations in our collaboration with Bristol Myers Squibb in April 2025 as well as a lower estimated percentage of performance obligation completion for 2025 compared to 2024 in the Moderna, Astellas, and Regeneron collaborations. In 2025, CytomX remained focused on controlling costs and efficiently progressing its pipeline programs. Total operating expense for 2025 was $98.6 million compared to $113.1 million for 2024, a decrease of $14.5 million. Research and development expenses decreased by $14.7 million during the year ended December 31, 2025, to $68.7 million compared to $83.4 million for 2024. Research and development expenses decreased primarily due to lower general research and development expenses as a result of our January 2025 restructuring and reduced expenses for CX-904, partially offset by increased manufacturing and clinical spend on Varseta-M. General and administrative expenses increased by $0.1 million during the year ended December 31, 2025, to $29.8 million, compared to $29.7 million for 2024. The general and administrative expenses for 2025 included $1.1 million of one-time restructuring expenses partially offset by reduced personnel related expenses and legal and consulting related expenses. About CytomX Therapeutics, Inc. CytomX is a clinical-stage, oncology-focused biopharmaceutical company focused on developing novel conditionally activated, masked PROBODY ® therapeutics designed to be localized to the tumor microenvironment. By pioneering a novel pipeline of localized biologics, powered by its PROBODY therapeutic platform, CytomX’s vision is to create safer, more effective therapies for the treatment of cancer. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), cytokines and T-cell engagers. CytomX’s clinical-stage pipeline includes varsetatug masetecan (Varseta-M; CX-2051) and CX-801. Varseta-M is a masked, conditionally activated ADC armed with a topoisomerase-1 inhibitor payload and directed toward epithelial cell adhesion molecule (EpCAM). EpCAM is a highly expressed tumor antigen that has previously been undruggable due to expression on normal tissues. Varseta-M is designed to open a therapeutic window for this high potential target and is initially being developed for the treatment of metastatic colorectal cancer. Varseta-M was discovered in collaboration with ImmunoGen, now part of AbbVie. CX-801 is a masked interferon alpha-2b PROBODY ® cytokine with broad potential applicability in traditionally immuno-oncology sensitive as well as insensitive (cold) tumors. CX-801 is initially being developed for the treatment of metastatic melanoma. CytomX has established strategic collaborations with multiple leaders in oncology, including Amgen, Bristol Myers Squibb, Regeneron and Moderna. For more information about CytomX and how it is working to make conditionally activated treatments the new standard-of-care in the fight against cancer, visit and follow us on LinkedIn and X (formerly Twitter) . CytomX Therapeutics Forward-Looking Statements This press release includes forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors that are difficult to predict, may be beyond CytomX’s control, and may cause the actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied in such statements, including those related to the future potential of partnerships or collaboration agreements and projected cash runway. Accordingly, you should not rely on any of these forward-looking statements, including those relating to the potential benefits, safety and efficacy or progress of CytomX’s or any of its collaborative partners’ product candidates, including varsetatug masetecan (Varseta-M; CX-2051) and CX-801, the potential benefits or applications of CytomX’s PROBODY ® therapeutic platform, CytomX's planned interactions with the U.S. Food and Drug Administration and the ability to align on a potential registrational study design and regulatory pathway for varsetatug masetecan, CytomX’s or its collaborative partners’ ability to develop and advance product candidates into and successfully complete clinical trials, including the ongoing and planned clinical trials of varsetatug masetecan and CX-801 and the timing of initial and ongoing data availability for CytomX’s clinical trials, including varsetatug masetecan and CX-801, and other development milestones. Risks and uncertainties that contribute to the uncertain nature of the forward-looking statements include: the unproven nature of CytomX’s novel PROBODY ® therapeutic technology; uncertainties around the Company’s ability to raise sufficient funds to carry out its planned research and development; CytomX’s clinical trial product candidates are in the initial stages of clinical development and its other product candidates are currently in preclinical development, and the process by which preclinical and clinical development could potentially lead to an approved product is long and subject to significant risks and uncertainties, including the possibility that the results of preclinical research and early clinical trials, including initial varsetatug masetecan clinical trial results, may not be predictive of future results; the possibility that CytomX’s clinical trials will not be successful; the possibility that current preclinical research may not result in additional product candidates; CytomX’s dependence on the success of varsetatug masetecan and CX-801; CytomX’s reliance on third parties for the manufacture of the Company’s product candidates; possible regulatory developments in the United States and foreign countries, including China and the European Union; and the risk that we may incur higher costs than expected for research and development. Additional applicable risks and uncertainties include those relating to CytomX’s preclinical research and development, clinical development, and other risks identified under the heading "Risk Factors" included in CytomX’s Annual Report on Form 10-K filed with the SEC on March 16, 2026. The forward-looking statements contained in this press release are based on information currently available to CytomX and speak only as of the date on which they are made. CytomX does not undertake and specifically disclaims any obligation to update any forward-looking statements, whether as a result of any new information, future events, changed circumstances or otherwise. PROBODY is a U.S. registered trademark of CytomX Therapeutics, Inc. All other trademarks are the properties of their respective owners. Company Contact: Chris Ogden SVP, Chief Financial Officer cogden@cytomx.com Investor Contact: Precision AQ Stephanie Ascher Stephanie.Ascher@precisionaq.com Media Contact: Precision AQ Colleen Ketchum Colleen.ketchum@precisionaq.com CYTOMX THERAPEUTICS, INC. BALANCE SHEETS (in thousands, except share and per share data) December 31, December 31, 2025 2024 Assets Current assets Cash and cash equivalents $ 12,667 $ 38,052 Short-term investments 124,385 62,571 Accounts receivable 2,013 3,103 Prepaid expenses and other current assets 4,856 3,579 Total current assets 143,921 107,305 Property and equipment, net 1,304 2,467 Intangible assets, net 438 583 Goodwill 949 949 Restricted cash 1,527 1,027 Operating lease right-of-use asset 3,396 8,136 Other assets 31 66 Total assets $ 151,566 $ 120,533 Liabilities and Stockholders' Equity (Deficit) Current liabilities Accounts payable $ 1,301 $ 1,088 Accrued liabilities 14,197 12,338 Operating lease liabilities - short term 4,240 5,145 Deferred revenue, current portion 26,877 67,201 Total current liabilities 46,615 85,772 Deferred revenue, net of current portion 1,590 26,862 Operating lease liabilities - long term — 4,240 Other long-term liabilities 4,353 4,115 Total liabilities 52,558 120,989 Commitments and contingencies Stockholders' equity (deficit) Convertible preferred stock — — Common stock 2 1 Additional paid-in capital 810,844 691,095 Accumulated other comprehensive income 111 27 Accumulated deficit (711,949 ) (691,579 ) Total stockholders' equity (deficit) 99,008 (456 ) Total liabilities and stockholders' equity (deficit) $ 151,566 $ 120,533 CYTOMX THERAPEUTICS, INC. STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) (in thousands, except share and per share data) Year Ended December 31, 2025 2024 Revenues $ 76,201 $ 138,103 Operating expenses: Research and development 68,728 83,382 General and administrative 29,837 29,726 Total operating expenses 98,565 113,108 Income (loss) from operations (22,364 ) 24,995 Interest income 5,206 7,136 Other income (expense), net 28 (38 ) Income (loss) before income taxes (17,130 ) 32,093 Provision for income taxes 238 224 Net income (loss) (17,368 ) 31,869 Deemed dividend on warrants (3,002 ) — Net income (loss) attributable to common stockholders $ (20,370 ) $ 31,869 Other comprehensive income (loss): Unrealized gain (loss) on available-for-sale investments, net of tax 84 (68 ) Total comprehensive income (loss) $ (17,284 ) $ 31,801 Net income (loss) per share: Basic $ (0.15 ) $ 0.38 Diluted $ (0.15 ) $ 0.38 Weighted average common shares used to compute net income (loss) per share Basic 137,935,873 84,439,303 Diluted 137,935,873 84,745,116 _____________________________ 1 Merck & Co., Inc. (2018). Sylatron (peginterferon alfa-2b) prescribing information. U.S. Food and Drug Administration