预约演示

更新于：2025-05-07

Sodium Neohouttuynate

新鱼腥草素钠

更新于：2025-05-07

概要

基本信息

药物类型

小分子化药

别名

Lathanol、Lathanol LAL、Sulfoacetic acid dodecyl ester S-sodium salt

+ [2]

靶点-

作用方式-

作用机制-

治疗领域

感染呼吸系统疾病泌尿生殖系统疾病

在研适应症

盆腔炎呼吸道感染宫颈炎

非在研适应症-

原研机构

海口康力元制药有限公司

在研机构

海口康力元制药有限公司

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

中国 (2004-01-01),

盆腔炎呼吸道感染宫颈炎

最高研发阶段(中国)批准上市

特殊审评-

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结构/序列

分子式C14H28NaO5S

InChIKeyMCNJOIMMYWLFBA-UHFFFAOYSA-N

CAS号1847-58-1

关联

100 项与新鱼腥草素钠相关的临床结果

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100 项与新鱼腥草素钠相关的转化医学

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100 项与新鱼腥草素钠相关的专利（医药）

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项与新鱼腥草素钠相关的文献（医药）

2023-05-25·Tenside Surfactants Detergents

Potential of binary mixtures of sodium lauryl sulfoacetate (SLSA) and alkyl polyglucoside (APG₁₀) as oil degreaser

作者: Shah, Zainal Abidin M. H. ; Raudhah, Azman N. ; Aisah, Asli U. ; Dina, Sakaria N.

AbstractThe industry is challenged to replace toxic chemical-based surfactants with environmentally friendly and biodegradable surfactants. In this study, binary mixtures of sodium lauryl sulfoacetate (SLSA) and an alkyl polyglucoside (APG10) in various proportions were investigated for their effectiveness as degreasing agents. Efficacy was characterised using surface tension measurements, oil dispersion tests, emulsification, pH and cleaning efficacy in removing engine oil from a metal plate. The surface tension results for all solutions showed a critical micelle concentration of 1500 ppm. The dispersion tests (with oil:surfactant ratios of 1:2 and 1:3) showed that the oil was fully dispersed at an oil:surfactant ratio of 1:2 i.e., at a concentration of 2500 ppm SLSA and 2000 ppm of a binary solution with a volume ratio of SLSA:APG10 of 75:25. At a ratio of 1:3, the oil was fully dispersed with 2500 ppm of a binary solution with a ratio of SLSA:APG10 of 75:25. Overall, the solution with a volume ratio of SLSA:APG10 of 75:25 was the most favourable. The results also showed that a solution containing only SLSA had good potential as a degreaser, as it achieved a cleaning performance of 90% in removing oil from the metal plate despite low emulsification levels (E24) for both surfactants. In summary, a combination of these two green surfactants can be used effectively as a degreasing agent.

2023-01-01·Current pharmaceutical biotechnology

Sodium New Houttuyfonate Effectively Improves Phagocytosis and Inhibits the Excessive Release of Inflammatory Factors by Repressing TLR4/NF-Кb Pathway in Macrophages.

Article

作者: Wu, Daqiang ; Hu, Mengxue ; Song, Cheng ; He, Xiaomei ; Liu, Longyun ; Ni, Mengru ; Chen, Cunwu

BACKGROUNDSodium new houttuyfonate (SNH) is an adduct of houttuyfonate, which is the main component of the common Chinese medicinal plant Houttuynia cordata. SNH has been widely used in antibacterial and anti-inflammatory treatments in clinics. However, the exact antimicrobial mechanism of SNH is still unclear, despite its mild direct antimicrobial activity in vitro. Objectives: The aim of this study is to investigate the effect and possible mechanism of SNH on macrophages against bacteria in vitro.METHODSIn this study, we assessed the antibacterial and anti-inflammatory effects of SNH on the RAW264.7 macrophage cell line against Pseudomonas aeruginosa, a major opportunistic pathogen.RESULTSFirstly, we found that SNH showed minimal toxicity on RAW264.7 macrophages. Secondly, our results indicated that SNH effectively inhibited the inflammatory reaction of macrophages stimulated by P. aeruginosa. We also found that SNH improved the phagocytosis and killing effect of RAW264.7 macrophages against P. aeruginosa in vitro. Furthermore, our results revealed that SNH effectively inhibited the expression of the TLR4/NF-кB pathway in macrophage RAW264.7 co-incubated with P. aeruginosa in vitro.CONCLUSIONBased on our findings, SNH can significantly improve the phagocytosis of macrophages and inhibit the excessive release of inflammatory factors by repressing the TLR4/NF-кB pathway.

2022-05-01·Desalination and Water Treatment

Removal of Zn(II) and Cr(VI) ions from aqueous medium by anionic plant-based surfactant impregnated activated carbon

作者: Ahya, Muhammad Khairil ; Ahmad, Normadyzah ; Puasa, Siti Wahidah ; Abdul Ghani, Fazni Susila ; Zulkupli, Noor Azzila ; Rahim, Nik Nur Ainan Rasyidah Abd

Herein, anionic plant-based surfactant (sodium lauryl sulfoacetate, SLSA) was introduced for impregnation onto activated carbon (AC).This study was intended to assess its use as a potential adsorbent for removing Zn(II) and Cr(VI) ions from aqueous medium.The virgin and the impregnated AC were characterised using Brunauer-Emmett-Teller anal. and Fourier-transform IR spectroscopy.Meanwhile, their performances to remove each metal ion were measured through batch adsorption experiments over a range of SLSA concentrations (10-175 mg/L) in 6 h contact time.The results revealed that Zn(II) ion removal was gradually increased as the SLSA concentration increased.The maximum removal was obtained at SLSA concentration of 75 mg/L (SIAC-75) with 31.66% of Zn(II) ion removal.However, an opposite trend of Cr(VI) ion removal was observed as the SLSA concentration increased.It is proposed that electrostatic interaction mechanism may occur during the adsorption process.The introduction of sulfonate group (OSO₃^-) via SLSA impregnation imparted a neg. charged surface on AC, thus resulting in an electrostatic attraction between Zn(II) ion.However, as Cr(VI) ion may dissociate into chromate (CrO₄^2-)ion, an electrostatic repulsion would occur.Therefore, in this study, the modified adsorbent prepared would be potentially preferred to remove Zn(II) ion.

100 项与新鱼腥草素钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB13157

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
盆腔炎	中国	海口康力元制药有限公司	2004-01-01
呼吸道感染	中国	海口康力元制药有限公司	2004-01-01
宫颈炎	中国	海口康力元制药有限公司	2004-01-01