预约演示
更新于：2025-05-17
Ibuprofen Lysine
布洛芬赖氨酸
更新于：2025-05-17
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C19H32N2O4 |
InChIKeyIHHXIUAEPKVVII-ZSCHJXSPSA-N |
CAS号57469-77-9 |
关联
9
项与 布洛芬赖氨酸 相关的临床试验NCT05340582
Co-administration of Acetaminophen with Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants - the ACEDUCT Trial
IRCT20140527017880N8
Comparative evaluation of the effect of ibuprofen lysine & gelofen - acetaminophen on postoperative endodontic dental pain with irreversible pulpaitis
IRCT20130812014333N131
comparison of the effect of ibuprofen lysine with gelofen-acetaminophen on postoperative pain of mandibular third molars surgery
100 项与 布洛芬赖氨酸 相关的临床结果
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100 项与 布洛芬赖氨酸 相关的转化医学
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100 项与 布洛芬赖氨酸 相关的专利（医药）
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25,302
项与 布洛芬赖氨酸 相关的文献（医药）2025-12-31JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Bioactivity profiling of
Sanghuangporus lonicerinus
: antioxidant, hypoglycaemic, and anticancer potential via
in-vitro
and
in-silico
approaches
Article
作者: Živanović, Nemanja ; Abdullaev, Ikram ; Abbasi, Arshad Mehmood ; Bekić, Sofija ; Ghosh, Soumya ; Rašeta, Milena ; Chen, Jia Jia ; Wan-Mohtar, Wan Abd Al Qadr Imad ; Gafforov, Yusufjon ; Mišković, Jovana ; Lim, Young Won ; Abdullaev, Bekhzod ; Yarasheva, Manzura ; Rapior, Sylvie ; Petri, Edward
This study investigates the mycochemical profile and biological activities of hydroethanolic (EtOH), chloroform (CHCl3), and hot water (H2O) extracts of Sanghuangporus lonicerinus from Uzbekistan. Antioxidant capacity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), NO, and FRAP assays, and in vitro hypoglycaemic effects were evaluated through α-amylase and α-glucosidase inhibition. Antiproliferative potential was explored by analysing the binding affinities of EtOH and H2O extracts to estrogen receptor α (ERα), ERβ, androgen receptor (AR), and glucocorticoid receptor (GR), with molecular docking providing structural insights. LC-MS/MS analysis revealed solvent-dependent phenolic profiles, with the EtOH extract containing the highest total phenolic content (143.15 ± 6.70 mg GAE/g d.w.) and the best antioxidant capacity. The EtOH extract showed significant hypoglycaemic effects, with 85.29 ± 5.58% inhibition of α-glucosidase and 41.21 ± 0.79% inhibition of α-amylase. Moderate ERβ binding suggests potential for estrogen-mediated cancer therapy, while strong AKR1C3 inhibition by the EtOH extract supports its therapeutic potential.
2025-10-01JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Unveiling the effect of SWCNT as the dopants of TiO2 in pharmaceutical mixture photocatalytic removal from water and wastewater
作者: Walczak, Natalia ; Krzyszczak-Turczyn, Agnieszka ; Czech, Bozena
Increased pharmaceuticals and personal care products usage increases their disposal.Low biodegradability, poor removal during conventional treatment, and long-range transport make them persistent pollutants.Removal of such pollutants is of great importance nowadays and requires advanced techniques.Photocatalysis using visible light is a promising method for detoxifying water and wastewater.In the presented studies the effect of Single-Walled Carbon Nanotubes (SWCNT) on the activity of TiO2-SiO2 was tested.The photocatalysts were characterized by high available surface area (280-525 m2 g-1), and reduced band gap energy (2.84-3.03 eV) suggesting good photocatalytic behavior under vis irradiationThe broad characteristics of the photocatalysis revealed that the greatest changes in the photocatalysts′ properties were noted when the amount of doped SWCNT was between 1.7-3.5 wt%. k1 values ranged from 0.0038 min-1 (ibuprofen), 0.0204 min-1 (carbamazepine), 0.0626 min-1 (oseltamivir), to 0.0783 min-1 (metoprolol).The effect of inorganic ions, dissolved organic matter, and ionic strength were estimatedThe process mechanism was examined using radical scavengers and the process was performed using tap water and treated wastewater.The results confirmed that obtained materials with enhanced surface area and porosity, abundance of surface functional groups, and visible light activation should reveal a great potential for pollutant removal.
2025-09-01TALANTA
One-stop solution for wide polar range compounds: Preparation and application of quaternary ammonium salt molecular cage stationary phase
Article
作者: Li, Zhen ; Lan, Tao ; Pei, Dong ; Liu, Sheng ; Zhu, He ; Ding, Ruifang ; Lv, Mei ; Wang, Litao ; Zhang, Yangyang ; Zuo, Ying ; Hu, Jinxia
The separation and analysis of complex samples with wide polar range on a singular column is always a difficult problem in separation and analysis science. In this study, the RCC3-R molecular cage modified with the quaternary ammonium salt stationary phase (RCC3-GQ@silica) was successfully prepared and applicated in the separation of wide polar range compounds. In the Reverse Phase Liquid Chromatography (RPLC) mode, due to the hydrophobicity and π-π interactions provided by the cyclohexane and benzene rings in the molecular cage structure, this stationary phase demonstrated effective separation capabilities for alkylbenzenes, polycyclic aromatic hydrocarbons, phenols, and anilines. In the Hydrophilic Interaction Liquid Chromatography (HILIC) mode, the study explored the separation performance of this stationary phase for sugars and inorganic salts. Utilizing a mixed mode of HILIC/RPLC/Ion Exchange Chromatography (IEC), effective separation was achieved for sulfonamides, nucleosides, acids, and amino acids, indicating good separation effects for medium to strongly polar compounds as well as various hydrophilic compounds. Combining various separation modes, the RCC3-GQ@silica stationary phase successfully separated 91 compounds across 15 categories. These results not only demonstrate the potential of the stationary phase in expanding the range of polarities of analyzable compounds and achieving multipurpose use on a single column, but also confirm its effective separation of nucleosides in pure water systems, further emphasizing the significant application potential of RCC3-GQ@silica stationary phase in the field of green chemistry.
100 项与 布洛芬赖氨酸 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 动脉导管未闭 | 美国 | 2006-04-13 | |
| 关节炎 | 澳大利亚 | 2003-08-12 | |
| 背痛 | 澳大利亚 | 2003-08-12 | |
| 痛经 | 澳大利亚 | 2003-08-12 | |
| 头痛 | 澳大利亚 | 2003-08-12 | |
| 偏头痛 | 澳大利亚 | 2003-08-12 | |
| 肌肉骨骼疼痛 | 澳大利亚 | 2003-08-12 | |
| 紧张型头痛 | 澳大利亚 | 2003-08-12 | |
| 牙痛 | 澳大利亚 | 2003-08-12 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1期 | - | 32 | 願簾獵鬱憲壓鹹鹹蓋範(鑰艱蓋餘膚繭糧鑰鏇範) = 繭淵壓淵鏇願獵壓衊壓 糧繭衊蓋鏇鹽艱醖襯構 (簾製襯願糧選夢製鏇築 ) | - | 2018-08-01 | ||
Ibuprofen liquid capsule | 願簾獵鬱憲壓鹹鹹蓋範(鑰艱蓋餘膚繭糧鑰鏇範) = 網構襯網憲餘觸膚膚夢 糧繭衊蓋鏇鹽艱醖襯構 (簾製襯願糧選夢製鏇築 ) |
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