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更新于：2025-04-19
Ibuprofen Lysine
布洛芬赖氨酸
更新于：2025-04-19
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C19H32N2O4 |
InChIKeyIHHXIUAEPKVVII-ZSCHJXSPSA-N |
CAS号57469-77-9 |
关联
9
项与 布洛芬赖氨酸 相关的临床试验NCT05340582
Co-administration of Acetaminophen with Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants - the ACEDUCT Trial
IRCT20140527017880N8
Comparative evaluation of the effect of ibuprofen lysine & gelofen - acetaminophen on postoperative endodontic dental pain with irreversible pulpaitis
IRCT20130812014333N131
comparison of the effect of ibuprofen lysine with gelofen-acetaminophen on postoperative pain of mandibular third molars surgery
100 项与 布洛芬赖氨酸 相关的临床结果
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100 项与 布洛芬赖氨酸 相关的转化医学
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100 项与 布洛芬赖氨酸 相关的专利（医药）
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23,952
项与 布洛芬赖氨酸 相关的文献（医药）2025-07-01SEPARATION AND PURIFICATION TECHNOLOGY
Enhancing electron transfer by amorphous FeOOH quantum dots during photocatalytic ozonation of ibuprofen
作者: Zhuang, Guanzheng ; Chen, Weirui ; Tian, Yingjing ; Bin, Liying ; Li, Ping ; Tang, Bing ; Yi, Yunqiang ; Fu, Siyou ; Li, Laisheng
Photocatalytic ozonation (PCO) process, as an effective water purification technol., was restrained by the low mass transfer and easy combination of photo-carriers (e-cb-h+vb) of conventional semiconductor catalysts.To these end, this study synthesized FeOOH quantum-dots (FeOOH QDs) and boosted the PCO activity by its amorphous structure with Ibuprofen (IBP) as model pollutant. 81.5 % IBP was removed by FeOOH QDs PCO, but it was 59.1 % and 61.2 % for α-FeOOH and β-FeOOH PCO, resp.FeOOH QDs PCO performed well at alk. environment but was easily inhibited by co-existing ions like SO2-4, HCO-3, NO-3, and Cl-.Compared with those of α-FeOOH and β-FeOOH, FeOOH QDs had the narrowest band gap and the lowest e-cb-h+vb recombination, therefore, its e-cb was more favorable to activate O3 into •OH.Tetrahedral Fe3+ and octahedral Fe3+ co-existed on FeOOH QDs and the tetrahedral Fe3+ was more conducive to the adsorption of O3 and contributed to its better PCO activity. •OH was the major reactive oxygen species accounting for IBP degradationDuring FeOOH QDs PCO process, 3 degradation routes were proposed basing on 13 kinds byproducts.T. E. S. T. result indicated that most of the intermediates were less toxic than IBP.This study is useful for developing catalysts for PCO process.
2025-07-01JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Albumin amplifies the dioxetane (AMPPD) chemiluminescence triggered by alkaline phosphatase: Light emerging from protein cavities
作者: Morgon, Nelson Henrique ; de Souza, Aguinaldo Robinson ; Yoguim, Mauricio Ikeda ; Ximenes, Valdecir Farias ; Barison, Leonardo Almeida
AMPPD is an abbreviation for 3-(2'-spiroadamantyl)-4-methoxy-4-(3-phosphoryloxy)-phenyl-1,2-dioxetane, a thermally stable 1,2-dioxetane derivative widely used as a chemiluminescent probe in clin. laboratories for enzyme immunoassays.AMPPD is a substrate for alk. phosphatase (ALP), the enzyme that catalyzes the remotion of the phosphoryl group of AMPPD, triggering light emission.This study investigated the impact of albumins on the AMPPD:ALP system and found that human serum albumin (HSA) increases the light emission efficiency of AMPPD:ALP by around 100 times.The efficiency of light enhancement varied depending on the type of albumin, with bovine (BSA), porcine (PSA), and rabbit (RSA) serum albumins being less effective than HSA.We conducted experiments to demonstrate that once hydrolyzed by ALP, the dephosphorylated AMPPD diffuses to site I of HSA.By studying the photophys. properties of the phenol ester generated after AMPPD cleavage, we found that its complexation with HSA caused a significant increase in its fluorescent efficiency, which explains the amplification of the chemiluminescence.Resonance energy transfer from the excited phenol ester to coumarin-153 was detected, confirming the presence of both mols. in the protein cavity.Hence, introducing fluorescent acceptors into the reaction system can adjust the emission wavelength.Besides the first direct evidence of albumin as an enhancer for chemiluminescence, the results highlight the potential interference of albumins on AMPPD-mediated assays and new biotechnol. applications.
2025-07-01SEPARATION AND PURIFICATION TECHNOLOGY
Degradation of multicomponent pharmaceutical mixtures by electrochemical oxidation: Insights about the process evolution at varying applied currents and concentrations of organics and supporting electrolyte
作者: Marti-Calatayud, M. C. ; Perez-Herranz, V. ; Patino-Cantero, I. ; Carrillo-Abad, J. ; Giner-Sanz, J. J. ; Garcia-Gabaldon, M. ; Balseviciute, A.
Electrochem. oxidation is a treatment process that can achieve high degrees of removal of organic emerging pollutants from wastewater.The present study evaluates the removal and mineralization degrees achieved when treating by electrochem. oxidation multicomponent mixtures containing three model pharmaceuticals: atenolol, ibuprofen and norfloxacin.The progress of the removal process at different applied currents was followed through the evolution of the degree of mineralization and the concentration of ionic byproducts.The three compounds can be effectively removed, although atenolol was found to be the most recalcitrant one.An increase in the degree of mineralization with current was noted for currents above 200 mA, reaching a maximum value of 98.8% for an operation current of 800 mA.In general, total organic carbon declines linearly during the first stages of the process, while an exponential trend appears at the latter stages when complete mineralization is approached.Peak concentrations of some byproducts, such as formate, ammonia and nitrite ions, were detected at intermediate operating times.Such compounds are further oxidized, thus being depleted from the solution towards the end of the process.On the contrary, a final plateau concentration is reached for fluoride and nitrate ions.Such events occur faster at higher operation currents, thus denoting an accelerated process of mineralization.However, higher currents also induce a decrease in the mineralization current efficiency and an increase in the specific energy consumption.Notably, for a given current, the process evolves at a similar pace regardless of the concentration of organics and supporting electrolyte.In terms of net mineralization, this implies a more efficient utilization of the generated hydroxyl radicals in the removal of organics for higher solution concentrationsExperiments conducted at constant current and organics concentration, but varying the concentration of sodium sulfate, confirmed that hydroxyl radicals are the main species responsible for the removal of pharmaceuticals, whereas the oxidation of the supporting electrolyte only plays a secondary role.
100 项与 布洛芬赖氨酸 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 动脉导管未闭 | 美国 | 2006-04-13 | |
| 关节炎 | 澳大利亚 | 2003-08-12 | |
| 背痛 | 澳大利亚 | 2003-08-12 | |
| 痛经 | 澳大利亚 | 2003-08-12 | |
| 头痛 | 澳大利亚 | 2003-08-12 | |
| 偏头痛 | 澳大利亚 | 2003-08-12 | |
| 肌肉骨骼疼痛 | 澳大利亚 | 2003-08-12 | |
| 紧张型头痛 | 澳大利亚 | 2003-08-12 | |
| 牙痛 | 澳大利亚 | 2003-08-12 |
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