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更新于：2026-07-11
Ibuprofen Lysine
布洛芬赖氨酸
更新于：2026-07-11
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C19H32N2O4 |
InChIKeyIHHXIUAEPKVVII-ZSCHJXSPSA-N |
CAS号57469-77-9 |
关联
10
项与 布洛芬赖氨酸 相关的临床试验NCT05340582
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants - The ACEDUCT Trial
IRCT20140527017880N8
Comparative evaluation of the effect of ibuprofen lysine & gelofen - acetaminophen on postoperative endodontic dental pain with irreversible pulpaitis
IRCT20130812014333N131
comparison of the effect of ibuprofen lysine with gelofen-acetaminophen on postoperative pain of mandibular third molars surgery
100 项与 布洛芬赖氨酸 相关的临床结果
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100 项与 布洛芬赖氨酸 相关的转化医学
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100 项与 布洛芬赖氨酸 相关的专利（医药）
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19,467
项与 布洛芬赖氨酸 相关的文献（医药）2026-05-04Expert Opinion On Drug Safety
Potential drugs for reducing the occurrence of immune checkpoint inhibitor-induced interstitial lung disease: an exploratory study using the JADER and FAERS databases
Article
作者: Kondo, Masashi ; Koseki, Takenao ; Hatano, Masakazu ; Utsunomiya, Ayaka ; Yamada, Shigeki ; Imaizumi, Kazuyoshi
BACKGROUND:
Immune checkpoint inhibitors (ICIs) play a central role in cancer immunotherapy. However, the occurrence of immune-related adverse events, especially ICI-induced interstitial lung disease (ICI-ILD), is life-threatening and affects the effectiveness of ICI treatment. This study aimed to explore potential drugs to mitigate ICI-ILD occurrence using data from the Japanese Adverse Drug Event Report (JADER) and the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS [JAPIC AERS]).
RESEARCH DESIGN AND METHODS:
We investigated concomitant drugs that reduce ILD associated with four ICIs - nivolumab, pembrolizumab, atezolizumab, and durvalumab - across the JADER and FAERS databases. Subsequently, the identified common concomitant drugs that reduce the occurrence of ICI-ILD were detected and analyzed.
RESULTS:
We found omega-3 fatty acids, loperamide, and amlodipine as common concomitant drugs that reduced ICI-ILD occurrence in both the JADER and FAERS databases. Omega-3 fatty acids reportedly have many effects in animal models of drug-induced ILD, including their association with ILD in humans and anti-inflammatory effects against ICI-ILD. However, loperamide and amlodipine reportedly have minimal effects against ILD, thereby necessitating further evaluation.
CONCLUSION:
Omega-3 fatty acids have emerged as potential agents for reducing ICI-ILD occurrence, as evidenced by findings from two different pharmacovigilance databases.
2026-04-01CERAMICS INTERNATIONAL
Influence of Halloysite Nanotubes from different deposits on the degradation of organic molecules
作者: Piccionello, Antonio Palumbo ; Merir, Roufaida ; Lisuzzo, Lorenzo ; Lazzara, Giuseppe ; Ferlito, Chiara ; Cavallaro, Giuseppe ; Rizzo, Carla
In this work, Halloysite Nanotubes (HNTs) sourced from different geol. deposits (Dragon mine and Latah County in the United States, Matauri Bay in New Zealand and Guelma in Algeria) were studied for the catalytic and photocatalytic degradations of model organic mols., which are L (+) ascorbic acid and ibuprofen, resp., in order to assess their distinct impacts on reactions activity.The nanoclays were fully characterized by different techniques (TGA, XRF, XRD, FTIR, ζ-potential, DLS, TEM, etc.) which enlightened differences in the morphol., thermal, chem. properties.As a direct consequence, the degradation of ascorbic was enhanced due to the presence of zinc and manganese oxide in the samples, whereas the photochem. degradation of ibuprofen, which was studied by using a photoreactor, was slowed down or speeded up depending on the particular clay used.These findings are crucial for the plethora of different applications and demonstrates the significant impact HNTs can exert on catalysis.This investigation opens up new perspectives of research for accurately selecting halloysite over other nanoclays.
2026-03-21JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
Cubosomes – A novel approach to taste masking using ibuprofen as a model drug
作者: Das, Dibya ; Palan, Forum ; Pai, Rohan ; Chatterjee, Bappaditya ; Bose, Anirbandeep
Taste masking of any pediatric oral formulation has always been a hurdle.Cubosomses, a type of lyotropic liquid crystal, have been used in this research to develop an oral formulation of ibuprofen.Ibuprofen cubosomes were prepared with glyceryl monooleate (GMO) and poloxamer 407 by high-pressure homogenization (HPH) technique.The formulation experiments were performed using a 2-level, 3-factor central composite design with drug loading, GMO concentration and HPH pressure as independent variables and vesicle size, entrapment efficiency and %drug content as the dependent variables.The most suitable ibuprofen cubosomes showed 94 nm vesicle size, -17.5 mV zeta potential, >75% drug content and >96% entrapment efficiency.The cubosomes released more than 80% of the drug within 2 h.In vitro taste masking study showed significantly lower drug release than its bitterness threshold.An in vivo taste masking study in healthy adult volunteers showed significant taste masking compared to the marketed formulation and ibuprofen pure suspension. % of the volunteers observed cubosomes as not bitter.In contrast, 67% of the volunteers reported marketed suspension as very bitter.The developed cubosomes resulted in phys. stability for three months of proper storage.The study has successfully achieved considerable taste-masking using cubosomes with GMO and Poloxmaer 407 formulation.This proof of concept can initiate a new field of research in taste-masked oral liquid formulation.
100 项与 布洛芬赖氨酸 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 动脉导管未闭 | 美国 | 2006-04-13 | |
| 关节炎 | 澳大利亚 | 2003-08-12 | |
| 背痛 | 澳大利亚 | 2003-08-12 | |
| 痛经 | 澳大利亚 | 2003-08-12 | |
| 头痛 | 澳大利亚 | 2003-08-12 | |
| 偏头痛 | 澳大利亚 | 2003-08-12 | |
| 肌肉骨骼疼痛 | 澳大利亚 | 2003-08-12 | |
| 紧张型头痛 | 澳大利亚 | 2003-08-12 | |
| 牙痛 | 澳大利亚 | 2003-08-12 |
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临床结果
临床结果
适应症
分期
评价
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临床1期 | - | 32 | 齋積鬱願窪願製憲網窪(廠蓋衊膚衊廠艱鬱網觸) = 簾網製願獵醖衊蓋願觸 蓋淵醖壓蓋憲夢範構簾 (窪願醖簾蓋構鹽製網襯 ) | - | 2018-08-01 | ||
Ibuprofen liquid capsule | 齋積鬱願窪願製憲網窪(廠蓋衊膚衊廠艱鬱網觸) = 獵鹽願艱簾顧顧艱選網 蓋淵醖壓蓋憲夢範構簾 (窪願醖簾蓋構鹽製網襯 ) |
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