亚硒酸钠(Sodium Selenite) - 在研适应症：硒缺乏症，结肠癌，白内障_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ASELEND、アセレンド

靶点-

作用方式-

作用机制-

治疗领域

其他疾病肿瘤消化系统疾病+ [1]

在研适应症

硒缺乏症结肠癌白内障

非在研适应症-

原研机构

Fujimoto Pharmaceutical Corp.

在研机构

Illinois CollegeSenju Pharmaceutical Co., Ltd.

Fujimoto Pharmaceutical Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2019-03-26),

硒缺乏症

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式H2Na2O3Se

InChIKeyCQRWCHXOXPSKFW-UHFFFAOYSA-N

CAS号10102-18-8

关联

7

项与亚硒酸钠相关的临床试验

NCT02393183

/ Withdrawn临床2/3期

The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease, a Placebo Controlled Randomized Clinical Trial

This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED:
β- Carotene (30 mg)
Vit C (100 mg)
Vit E (Alpha-Tocopherol Acetate): 60-200 IU
Calcium phosphate dihydrate (40 mg)
Zinc oxide (4 mg, elemental)
Copper gluconate (3.5 mg)
Sodium selenite 23 mg= Selenium 100 µg
Nicotinamide (a form of vit.B3) (10 mg)
in patients with mild Thyroid eye disease according to EUGOGO classification. To be given twice a day.

开始日期2019-07-15

申办/合作机构

Iran University of Medical Sciences & Health Services

IRCT20110123005670N28

/ Completed临床3期IIT

The effects of Na- selenite and Na- selenite -enriched yeast supplementation on glycemic status, lipid profile, oxidative and nitrosative stress in patients with coronary artery diseases.

开始日期2019-06-02

申办/合作机构

Tabriz University of Medical Sciences

NCT03081949

/ Completed临床4期IIT

Peripartum Cardiomyopathy in Nigeria (PEACE) A Registry to Study the Demographics, Social and Clinical Characteristics, Pathophysiology and Outcomes of Peripartum Cardiomyopathy in Nigeria

Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world. Unfortunately, much about the disease including its aetiology, epidemiology and treatment is not yet well described. This will be a prospective, national, multicenter cohort study, conducted in centres in Nigeria. It is expected that approximately 500 patients with PPCM and 500 apparently healthy pregnant women will be recruited over a 6-month period with follow-up at 3-monthly intervals for 18 months.

开始日期2017-06-12

申办/合作机构-

100 项与亚硒酸钠相关的临床结果

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100 项与亚硒酸钠相关的转化医学

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100 项与亚硒酸钠相关的专利（医药）

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9,193

项与亚硒酸钠相关的文献（医药）

2025-04-15·Journal of Applied Polymer Science

Plasma Assisted Surface Decoration of PLA Nonwoven Materials With Selenium Nanoparticles for Improvement of Antibacterial and Biocompatible Properties

作者: Luan, Rui ; Ren, Yu ; Yuan, Yuan ; Wang, Chunxia ; Zhao, Ziyao ; Li, Mei‐Xian

ABSTRACTThis study aimed to enhance the antibacterial and biocompatible properties of PLA nonwoven materials by plasma‐assisted surface decoration with selenium nanoparticles. PLA nonwoven materials were pretreated by plasma surface modification technology for varying durations. Subsequently, Se nanoparticles obtained from the redox reaction of sodium selenite were loaded onto the PLA surfaces through impregnation. SEM images demonstrated that plasma pretreatment enhances the uniformity of Se nanoparticles as well as the contents loaded onto the PLA nonwoven materials. Based on EDS analysis, the relative concentration of Se elements increased with longer plasma pretreatment durations, reaching 6.38% after 6 min of treatment. XPS analysis confirmed the presence of elemental selenium nanoparticles. Furthermore, the results of surface wettability showed that the surface of Se/PLA composites changed from hydrophobic to super hydrophilic after the plasma and Se combined treatment. Moreover, bacterial inhibition of the Se/PLA composites substantially improved with increasing plasma pretreatment time. The Se/PLA composites with 6 min of plasma pretreatment showed the best antibacterial performance and biocompatibility, with inhibition rates against Staphylococcus aureus and Escherichia coli reaching 95.75% and 75.54%, respectively, and cell viability was over 99% for L929 cells. These functionalized Se/PLA composites exhibit tremendous potential for applications in novel antibacterial materials.

2025-04-01·Journal of Photochemistry and Photobiology A: Chemistry

LaSrO3 perovskite quantum dots as a fluorescent probe for the detection of bilirubin and epinephrine via FRET and IFE mechanisms

作者: Park, Tae Jung ; Makwana, Kartik Pankajbhai ; Malek, Naved I. ; Deshpande, Madhura Pradeep ; Kailasa, Suresh Kumar

In this study, blue-emitting LaSrO₃ perovskite quantum dots (PQDs) were synthesized using a microwave-assisted sol-gel method.The as-prepared LaSrO₃ PQDs acted as a nano-fluorescent probe for detection of two biomarkers: bilirubin (BR) and epinephrine (EP).The fluorescence spectra of LaSrO₃ PQDs showed λEm/Ex at 421/336 nm, displaying quantum yield of 36.91%.Based on the remarkable fluorescence properties of LaSrO₃ PQDs, fluorescence sensing studies were performed for biomarkers assay.The emission spectral results of LaSrO₃ PQDs displayed remarkable fluorescence quenching by BR and EP via Forster resonance energy transfer and inner filter effect, resp.The detection limits were 10.48 and 17.04 nM for BR and EP, resp.The fluorescence quenching mechanisms were discussed in detail by various anal. techniques (fluorescence, UV-visible absorption, transmission electron microscopy, Fourier transform IR, and zeta potential).In addition, LaSrO₃ PQDs-based fluorescence sensing approach was successfully applied to quant. assays of EP in pharmaceutical samples and of BR in biofluids with satisfactory recovery results.

2025-04-01·Plant Physiology and Biochemistry

Molecular and physiological response of chives (Allium schoenoprasum) under different concentrations of selenium application by transcriptomic, metabolomic, and physiological approaches

Article

作者: Chen, Qiangwen ; Yu, Li ; Cheng, Shuiyuan ; Xu, Feng ; Zhang, WeiWei ; Cong, Xin

Selenium (Se) is a vital trace element for human health, and its uneven distribution in soil triggers Se deficiencies in some regions. Se biofortification has been demonstrated to mitigate this issue by producing Se-enriched crops. Chives (Allium schoenoprasum cv. 'sijixiaoxiangcong'), a simple-to-cultivate and fast-growing vegetable, offers a promising Se-accumulation ability. However, the physiological and molecular mechanisms underlying Se responses in chives remain unclear. This study applied sodium selenite at various doses to chives via root irrigation, and integrated strategies including multi-omics were employed to unfold the response mechanism. (1) Physiological data reveal that sodium selenite irrigation adversely affects the height, shoot weight, chlorophyll, and soluble sugar content of chives' aerial parts. However, chives exhibit a remarkable ability to accumulate selenium, reaching up to 40.21 mg kg^-1 DW under high Se exposure (160 mg L^-1); (2) Transcriptomic analysis revealed significant enrichment of the phenylpropanoid biosynthesis and plant hormone signal transduction pathways under Se treatment. Key DEGs, such as MAPKKK17_18, JAZs, and PCL, were identified as Se response candidates. Our findings show that selenomethionine is the primary form of Se accumulation, and DEGs linked to antioxidant defense and phenylpropanoid biosynthesis are crucial for mitigating Se stress; (3) Importantly, plant hormone signaling plays a central role by regulating phenylpropanoid metabolism and enhancing the antioxidant enzyme system, highlighting its significance in chives' Se tolerance. These results clarify the Se response mechanisms in chives and enable Se-enriched chive cultivation.

100 项与亚硒酸钠相关的药物交易

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研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
硒缺乏症	日本	Fujimoto Pharmaceutical Corp.	2019-03-26

未上市

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适应症	最高研发状态	国家/地区	公司	日期
结肠癌	临床前	美国	Illinois College	2009-05-01
白内障	临床前	美国	Senju Pharmaceutical Co., Ltd.	2003-05-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SECAR study (WCLC2013)	N/A	肿瘤	34	Sodiumselenite	(鏇範願簾憲淵廠壓廠獵) = One patient had a complete remission 鹽鏇製鹹鏇製窪鑰選觸 (艱夢築窪鹽鏇齋遞壓鏇 ) 更多	-	2013-10-28
ASTRO2007	N/A	-	-	Sodium Selenite	鏇積鏇蓋製築艱夢顧壓(網鏇窪繭構衊顧築願鹹) = 築簾膚蓋鹹醖糧選醖襯願範餘顧構繭齋鬱製憲 (遞衊範顧壓醖鏇衊淵簾 ) 更多	-	2007-11-01
				Sodium Selenite (Observation)	鏇積鏇蓋製築艱夢顧壓(網鏇窪繭構衊顧築願鹹) = 築襯獵鹹獵糧網鏇觸壓願範餘顧構繭齋鬱製憲 (遞衊範顧壓醖鏇衊淵簾 ) 更多
ASTRO2005	N/A	-	-	Sodium Selenite supplementation	(鹽繭鏇鑰築構窪顧繭艱) = 簾繭襯糧獵願壓壓膚遞顧獵鑰築蓋憲鏇壓繭願 (範醖築壓製鑰淵鏇鬱夢 ) 更多	-	2005-10-01
				Sodium Selenite (Control group (no supplementation))	(鹽繭鏇鑰築構窪顧繭艱) = 壓鏇糧範廠構鹽醖廠蓋顧獵鑰築蓋憲鏇壓繭願 (範醖築壓製鑰淵鏇鬱夢 ) 更多