亚硒酸钠(Sodium Selenite) - 在研适应症：硒缺乏症，结肠癌，白内障_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ASELEND、ASELEND

+ [1]

靶点-

作用机制-

治疗领域

其他疾病肿瘤消化系统疾病+ [1]

在研适应症

硒缺乏症结肠癌白内障

非在研适应症-

原研机构

Fujimoto Pharmaceutical Corp.

在研机构

Illinois CollegeSenju Pharmaceutical Co., Ltd.

Fujimoto Pharmaceutical Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2019-03-26),

硒缺乏症

最高研发阶段(中国)-

特殊审评-

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结构

分子式H2Na2O3Se

InChIKeyCQRWCHXOXPSKFW-UHFFFAOYSA-N

CAS号10102-18-8

关联

6

项与亚硒酸钠相关的临床试验

NCT02393183 / Withdrawn临床2/3期IIT

The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease, a Placebo Controlled Randomized Clinical Trial

This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED:
β- Carotene (30 mg)
Vit C (100 mg)
Vit E (Alpha-Tocopherol Acetate): 60-200 IU
Calcium phosphate dihydrate (40 mg)
Zinc oxide (4 mg, elemental)
Copper gluconate (3.5 mg)
Sodium selenite 23 mg= Selenium 100 µg
Nicotinamide (a form of vit.B3) (10 mg)
in patients with mild Thyroid eye disease according to EUGOGO classification. To be given twice a day.

开始日期2019-07-15

申办/合作机构

Iran University of Medical Sciences & Health Services

IRCT20110123005670N28 / Completed临床3期IIT

The effects of Na- selenite and Na- selenite -enriched yeast supplementation on glycemic status, lipid profile, oxidative and nitrosative stress in patients with coronary artery diseases.

开始日期2019-06-02

申办/合作机构

Tabriz University of Medical Sciences

NCT03081949 / Completed临床4期IIT

Peripartum Cardiomyopathy in Nigeria (PEACE) A Registry to Study the Demographics, Social and Clinical Characteristics, Pathophysiology and Outcomes of Peripartum Cardiomyopathy in Nigeria

Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world. Unfortunately, much about the disease including its aetiology, epidemiology and treatment is not yet well described. This will be a prospective, national, multicenter cohort study, conducted in centres in Nigeria. It is expected that approximately 500 patients with PPCM and 500 apparently healthy pregnant women will be recruited over a 6-month period with follow-up at 3-monthly intervals for 18 months.

开始日期2017-06-12

申办/合作机构-

100 项与亚硒酸钠相关的临床结果

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100 项与亚硒酸钠相关的转化医学

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100 项与亚硒酸钠相关的专利（医药）

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2,774

项与亚硒酸钠相关的文献（医药）

2024-12-01·Environmental Geochemistry and Health

Optimizing food waste bioconversion with sodium selenite-enhanced Lucilia sericata maggots: a sustainable approach for chicken feed production and heavy metal mitigation

Article

作者: Zheng, Chao ; Man, Yu Bon ; Wong, Ming Hung ; Cheng, Zhang

Recycling food waste by feeding it to insects can result in the continuous production of high-quality animal feed protein and organic fertilizer. However, the bioconversion efficiency and safety of using insects as feed protein for animal breeding are important factors limiting the development of this technology. Therefore, we aimed to optimize the efficiency of bioconversion of food waste using Lucilia sericata maggot (LSM). Sodium selenite (SS) was used to improve the quality and safety of each trophic-level organism. The results showed that an SS concentration of 15 mg kg^-1 w.w. in the food waste culture substrate (SS15), the yield and quality of the obtained LSMs were optimal. The total selenium (Se) content of LSMs was 82.4 ± 1.16 mg kg^-1 d.w., and non-inorganic Se accounted for 96.4% ± 2.01% of the total Se content. Additionally, the conversion efficiency of food waste was 18.7% higher than that in the control group (p < 0.05). When SS15 was used to raise maggots as a protein substitute for fish meal (commercial feed), the weight of the chickens and the crude protein content were 1.09-1.26 times and 1.09-1.13 times, respectively (p < 0.05), in comparison with the corresponding findings obtained with the use of ordinary maggots and commercial feed. In this group, glutathione peroxidase, superoxide dismutase, catalase, and immunoglobulin A and G activities were significantly higher than those obtained with the other feeds (p < 0.05). During this cyclic utilization process, the total Se content in chickens (0.31 ± 0.05 mg kg^-1 w.w. in the breast, 0.19 ± 0.01 mg kg^-1 w.w. in the leg, and 0.57 ± 0.01 mg kg^-1 w.w. in the liver) significantly increased (p < 0.05). Meanwhile, the Cu and Zn contents in the LSMs and chickens increased, whereas cadmium, lead, chromium, and nickel absorption was inhibited (p < 0.05). Health risk assessment based on the levels of Se and heavy metals showed that Se-enriched chickens produced using this method can be safely consumed.

2024-12-01·Biological Trace Element Research

Retraction Note: Effects of Cadmium Chloride and Sodium Selenite Alone or in Combination on the Liver of Male Sprague–Dawley Rats Assessed by Different Assays

作者: Jabeen, Farhat ; Chaudhry, Abdul Shakoor

2024-11-01·Journal of Biotechnology

Metabolic engineering of Escherichia coli for seleno-methylselenocysteine production

Article

作者: Wang, Fenghuan ; Yang, Hulin ; Liao, Yonghong ; Yin, Xian ; Wang, Shizhuo ; Zhao, Meiyi

Selenium (Se) is an essential trace element for life. Seleno-methylselenocysteine (SeMCys) can serve as a Se supplement with anticarcinogenic activity and can improve cognitive deficits. We engineered Escherichia coli for microbial production of SeMCys. The genes involved in the synthesis of SeMCys were divided into three modules-the selenocysteine (SeCys) synthesis, methyl donor synthesis and SMT modules-and expressed in plasmids with different copy numbers. The higher copy number of the SeCys synthesis module facilitated SeMCys production. The major routes for SeCys degradation were then modified. Deletion of the cysteine desulfurase gene csdA or sufS improved SeMCys production the most, and the strain that knocked out both genes doubled SeMCys production. The addition of serine in the mid-logarithmic growth phase significantly improved SeMCys synthesis. When the serine synthetic pathway was enhanced, SeMCys production increased by 12.5 %. Fed-batch culture for sodium selenite supplementation in the early stationary phase improved SeMCys production to 3.715 mg/L. This is the first report of the metabolic engineering of E. coli for the production of SeMCys and provide information on Se metabolism.

100 项与亚硒酸钠相关的药物交易

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研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
硒缺乏症	日本	Fujimoto Pharmaceutical Corp.	2019-03-26

未上市

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适应症	最高研发状态	国家/地区	公司	日期
结肠癌	临床前	美国	Illinois College	2009-05-01
白内障	临床前	美国	Senju Pharmaceutical Co., Ltd.	2003-05-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SECAR study (WCLC2013)	N/A	肿瘤	34	Sodiumselenite	(鏇獵構顧廠願膚糧繭鑰) = One patient had a complete remission 襯糧遞鑰繭窪觸憲鑰廠 (願鏇簾觸鑰蓋鹽鹹遞蓋 ) 更多	-	2013-10-28
ASTRO	N/A	-	-	Sodium Selenite	糧顧餘觸築選獵繭廠鹹(壓廠蓋蓋淵構餘製衊繭) = 顧糧願積襯齋鹽鏇糧膚繭構願觸網淵遞簾廠壓 (鹹遞齋糧窪遞構糧廠積 ) 更多	-	2007-11-01
				Sodium Selenite (Observation)	糧顧餘觸築選獵繭廠鹹(壓廠蓋蓋淵構餘製衊繭) = 鹽襯獵構積製製齋鹽憲繭構願觸網淵遞簾廠壓 (鹹遞齋糧窪遞構糧廠積 ) 更多
ASTRO	N/A	-	-	Sodium Selenite supplementation	(獵鏇觸夢衊顧鬱糧範鬱) = 築鏇遞遞構廠壓衊衊顧蓋繭蓋齋鏇窪遞窪蓋獵 (膚憲築觸構艱夢鏇鬱選 ) 更多	-	2005-10-01
				Sodium Selenite (Control group (no supplementation))	(獵鏇觸夢衊顧鬱糧範鬱) = 構蓋積艱鏇襯選醖築繭蓋繭蓋齋鏇窪遞窪蓋獵 (膚憲築觸構艱夢鏇鬱選 ) 更多