Phase 1/2a Open-Label, Dose-Escalation, Multicenter, FIH, Consecutive-Cohort, Clinical Trial of BI-1808, a Monoclonal Antibody to TNFR 2 as a Single Agent and in Combination With Pembrolizumab (MK-3475-D20) in Subjects With Advanced Malignancies

The goal of this first in human clinical trial is to test BI-1808 administered as single agent and in combination with pembrolizumab in subjects with advanced malignancies whose disease has progressed after standard therapy.
The main questions it aims to answer are:
* how safe and tolerable is BI-1808
* what is maximum tolerated or administrated dose
* to determine recommended dose for further clinical trials. Participants will receive infusions of BI-1808 alone or combination with pembrolizumab every 3 weeks.
For the purpose of this study, subjects with advanced malignancies includes subjects with advanced solid tumors and subjects with T-cell lymphoma (TCL),

开始日期2021-01-25

申办/合作机构

BioInvent International AB

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100 项与 BI-1808 相关的临床结果

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100 项与 BI-1808 相关的转化医学

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100 项与 BI-1808 相关的专利（医药）

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191

项与 BI-1808 相关的文献（医药）

2025-05-01·PEDIATRIC RESEARCH

Article

作者: Sepiashvili, Lusia ; Brydon, Avery ; Koroshegyi, Christine ; Rahman, Mehzabin ; Nguyen, Geoffrey C ; Huang, Vivian ; Ito, Shinya ; Ghayoori, Sholeh ; Dalvi, Pooja ; Nguyen, Geoffrey C. ; Gold, Anna ; Maxwell, Cynthia

BACKGROUND:

Tumor Necrosis Factor (TNF) are expressed in milk. Experimental data indicate enhanced brain growth and cognitive development in the mouse offspring given milk deficient in TNF and TNF-dependent chemokines. Although monoclonal antibodies against TNF (TNFmAb) are used during breastfeeding due to minimal milk excretion, whether it affects endogenous TNF levels in human milk is unclear.

METHODS:

A prospective cohort study was conducted in 26 breastfeeding women with inflammatory bowel disease (IBD) and 31 non-IBD women. Milk TNF and related chemokines were measured at 5-6 weeks postpartum (early-lactation point) as a primary endpoint and further determined at 13-14 weeks postpartum. In a subset of their infants, neurocognitive development was assessed at 12 and 18 months of age using Bayley-III tool.

RESULTS:

While milk TNF levels were not significantly different between the control and those with IBD, women with IBD receiving TNFmAb showed 70% lower median milk TNF than those without TNFmAb (P = 0.019) at early lactation period. TNF-dependent chemokines (MIP-1β and IP-10) also showed similar patterns. Neurocognitive development of the infants was not significantly different among the groups.

CONCLUSIONS:

Women with IBD receiving TNFmAb show significantly lower milk TNF/chemokines at 5-6 weeks postpartum than those without TNFmAb.

CLINICALTRIALS:

gov NCT03397108.

IMPACT:

We found that milk concentrations of Tumor Necrosis Factor (TNF) and TNF-dependent chemokines (MIP-1β and IP-10) are low in women with inflammatory bowel disease who are receiving anti-TNF monoclonal antibody (TNFmAb), compared to those without concurrent anti TNF therapy. While maternal use of TNFmAb during breastfeeding is considered inconsequential to infant health due to their low levels of milk excretion, it affects profiles of endogenous cytokines in milk. Our findings provide a rationale to investigate human implications of the animal data in the literature that suggest enhancement of neurocognitive development of the offspring fed with milk deficient in TNF-dependent chemokines.

2025-04-01·DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT

Update: Medikamentöse Therapie bei Colitis ulcerosa

Article

作者: Sonnenberg, Elena ; Weidinger, Carl ; Siegmund, Britta

Ulcerative colitis (UC) is classified as a chronic inflammatory bowel disease (IBD) and can present in various degrees of severity. In addition to mild courses of the disease, such as uncomplicated proctitis, which can often be successfully treated with topical 5-ASA formulations, complicated courses can be observed, which can sometimes be life-threatening. Affected patients are often considerably burdened and often severely restricted in their quality of life, as they suffer from numerous, often bloody bowel movements, which are accompanied by abdominal cramps, urgency and sometimes even incontinence. In addition, many UC patients suffer from concomitant extraintestinal inflammatory manifestations including skin manifestations like psoriasis, erythema nodosum or joint involvement such as spondylarthritis. For many years, steroids and conventional immunosuppressants such as azathioprine were the only treatment options available. Twenty years ago, the approval of the first anti-TNF antibody, Infliximab, marked a significant turning point in IBD therapy. Despite the continuous progress in drug therapy, the rates of primary and/or secondary treatment failure are still considerable. With this in mind, a large number of additional substances have been developed and approved for the treatment of UC in the recent years. In addition to TNF antibodies and their biosimilars, the anti-integrin vedolizumab, various Janus kinase (JAK) inhibitors, an interleukin (IL)-12/-23p40 antibody, various IL-23p19 antibodies and sphingosine-1-phosphate receptor (S1PR) modulators have broadened the therapeutic landscape and found their way into the clinical treatment of UC patients. In this article we will discuss case-based decision paths for the selection of fitting anti-inflammatory treatments in UC patients and summarize the principles of the different therapeutic strategies for UC.

2022-09-01·Arthritis & rheumatology (Hoboken, N.J.)

Article

作者: Ken Herrmann ; Athanasios Tsobanelis ; Lino M. Sawicki ; Xenofon Baraliakos ; Wolfgang P. Fendler ; Julian Kirchner ; Timo Bartel ; Christian Buchbender ; Juergen Braun ; Nils Martin Bruckmann ; Daniel B. Abrar ; Lale Umutlu ; Jens Theysohn ; Gerald Antoch ; Styliani Tsiami ; Christoph Rischpler

Objective:

Proof‐of‐concept trial to determine the effects of tumor necrosis factor inhibitor (TNFi) therapy on osteoblastic activity at sites of inflammatory and structural lesions in patients with radiographic axial spondyloarthritis (SpA), using fluorine 18–labeled NaF (18F‐NaF) positron emission tomography/magnetic resonance imaging (PET/MRI).

Methods:

Sixteen patients with clinically active radiographic axial SpA were prospectively enrolled to receive TNFi treatment and undergo 18F‐NaF PET/MRI of the sacroiliac (SI) joints and spine at baseline and at a follow‐up visit 3–6 months after treatment initiation. Three readers (1 for PET/MRI and 2 for conventional MRI) evaluated all images, blinded to time point. Bone marrow edema, structural lesions (i.e., fat lesions, sclerosis, erosions, and ankylosis), and 18F‐NaF uptake at SI joint quadrants and vertebral corners (VCs) were recorded.

Results:

Overall, 11 male and 5 female patients (mean age ± SD 38.6 ± 12.0 years) were followed up for a mean duration of 4.6 months (range 3–6). 18F‐NaF PET/MRI was conducted on SI joints for 16 patients and the spine for 10; 128 SI joint quadrants and 920 VCs were analyzed at each time point. At baseline, 18F‐NaF uptake was demonstrated in 96.0% of SI joint quadrants with bone marrow edema, 94.2% with sclerosis, and 88.3% with fat lesions. At follow‐up, 65.3% of SI joint quadrants with bone marrow edema (P < 0.001), 33.8% with sclerosis (P = 0.23), and 24.5% with fat lesions (P = 0.01) had less 18F‐NaF uptake, compared with baseline. For VCs, 18F‐NaF uptake at baseline was found in 81.5% of edges with sclerosis, 41.9% with fat lesions, and 33.7% with bone marrow edema. At follow‐up, 73.5% of VCs with bone marrow edema (P = 0.01), 53.3% with fat lesions (P = 0.03), and 55.6% with sclerosis (P = 0.16) showed less 18F‐NaF uptake, compared with baseline.

Conclusion:

Anti‐TNF antibody treatment led to a significant decrease in osteoblastic activity within 3–6 months, especially, but not solely, at sites of inflammation. Larger data sets are needed for confirmation of the antiosteoblastic effects of TNFi for the prevention of radiographic progression in axial SpA.

项与 BI-1808 相关的新闻（医药）

2026-02-26

·bioinvent.com

BioInvent International AB: Year-end report January 1 – December 31, 2025

“During 2025 we sharpened our clinical focus and resource allocation to accelerate our most advanced assets, BI-1808 (anti-TNFR2) and BI-1206 (anti-FcγRIIB), while pausing earlier programs to maximize the probability of success and near-term value creation.”- Martin Welschof, CEO BioInvent. EVENTS IN THE FOURTH QUARTER (R) Promising early Phase 2a monotherapy data for the company’s lead anti-TNFR2 antibody BI-1808 in T-cell lymphoma (TCL) presented at ASH 2025 (R) Impressive response data from ongoing Phase 2a trial of triple combination of the company’s lead anti-FcyRIIB antibody BI-1206, rituximab, and Calquence® in r/r non-Hodgkin’s Lymphoma (NHL) presented at ASH 2025 Phase 2a trial started evaluating BI-1206 in combination with pembrolizumab in treatment-naïve advanced or metastatic non-small cell lung cancer (NSCLC) and uveal melanoma Orphan Drug Designation from EMA for BI‑1808 for the treatment of cutaneous T-cell lymphoma (CTCL) Phase 1 data of the company’s second anti-TNFR2 antibody BI-1910 (currently paused) presented at SITC 2025 validates TNFR2 as a novel immunotherapy approach in advanced solid tumors Transgene and BioInvent presented translational data and updated clinical results on armed oncolytic virus BT-001 at ESMO 2025 BioInvent announced publication of preclinical and early clinical data for BI-1607 in HER2-positive advanced solid tumors EVENTS AFTER THE END OF THE PERIOD (R) Promising data in ongoing Phase 2a study for BI-1808 with KEYTRUDA® (pembrolizumab) for the treatment of recurrent ovarian cancer Updated clinical data sets solidify potential for both BI-1808 and pembrolizumab combination in ovarian cancer and BI-1206 triplet for the treatment of NHL, see pages 6 and 7 in the year-end report Nomination of two new board members ahead of 2026 Annual General Meeting; Kate Hermans and Scott Zinober EARLIER DURING 2025, IN BRIEF (R) Positive initial efficacy data from Phase 2a trial of triple combination of BI-1206, rituximab and Calquence® for the treatment of NHL BioInvent achieved ISO 26000 Verification, highlighting commitment to ESG and transparency (R) Promising Phase 2a monotherapy data for BI-1808 in CTCL presented at EHA 2025 Promising Phase 1 data of BI-1206 in combination with KEYTRUDA® (pembrolizumab) in solid tumors announced (R) XOMA Royalty purchased mezagitamab royalty and milestone rights held by BioInvent for up to USD 30 million Composition of matter patents for BI-1808 granted in US and Japan. They also cover the use of the antibody in the treatment of cancer FDA Fast Track Designation received for BI-1808 for the treatment of CTCL BI-1808 received Orphan Drug Designation from FDA for the treatment of TCL Strategic changes in portfolio to accelerate lead clinical programs and enhance value creation (R)= Regulatory event FINANCIAL INFORMATION Fourth quarter 2025• Net sales SEK 3.0 (21.4) million• Profit/loss after tax SEK -125.8 (-116.9) million• Profit/loss after tax per share before and after dilution SEK –1.91 (-1.78)• Cash flow from operating activities SEK-90.6 (-98.3) million January – December 2025• Net sales SEK 226.5 (44.7) million• Profit/loss after tax SEK -332.9 (-429.4) million• Profit/loss after tax per share before and after dilution SEK -5.06 (-6.53)• Cash flow from operating activities SEK -247.8 (-380.5) million• Liquid funds, current and long-term investments as of December 31, 2025: SEK 592.7 (867.2) million The complete interim report is available for download below and on the company’s website under Financial reports. INVITATION TO PRESENTATION OF THE YEAR-END REPORT 2025BioInvent’s CEO Martin Welschof will present the report together with CFO Stefan Ericsson. The presentation will be held in English.When: Thursday February 26, 2026, at 2:00 pm CET The webcast can be reached at https://bioinvent.events.inderes.com/q4-report-2025. If you wish to ask questions and participate via telephone, please register at the link below. After registration you will be provided with a phone number and a conference ID to access the conference.https://events.inderes.com/bioinvent/q4-report-2025/dial-in. The conference call will be made available on the company website after the call. About BioInventBioInvent International AB (Nasdaq Stockholm: BINV) is a clinical-stage biotech company that discovers and develops novel and first-in-class immuno-modulatory antibodies for cancer therapy, with drug candidates in ongoing clinical programs in Phase 1/2 trials for the treatment of hematological cancer and solid tumors. The Company's validated, proprietary F.I.R.S.T™ technology platform identifies both targets and the antibodies that bind to them, generating many promising new immune-modulatory candidates to fuel the Company's own clinical development pipeline and providing licensing and partnering opportunities. The Company generates revenues from research collaborations and license agreements with multiple top-tier pharmaceutical companies, as well as from producing antibodies for third parties in the Company's fully integrated manufacturing unit. More information is available at www.bioinvent.com. For further information, please contact:Cecilia Hofvander, VP Investor RelationsPhone: +46 (0)46 286 85 50Email: cecilia.hofvander@bioinvent.comBioInvent International AB (publ)Co. Reg. No.: 556537-7263Visiting address: Ideongatan 1Mailing address: 223 70 LUNDPhone: +46 (0)46 286 85 50www.bioinvent.com

临床结果孤儿药免疫疗法临床2期临床1期

2026-02-26

·BioSpace

BioInvent International AB: Year-End Report January 1 - December 31, 2025

LUND, SE / ACCESS Newswire / February 26, 2026 / BioInvent International (STO:BINV) - "During 2025 we sharpened our clinical focus and resource allocation to accelerate our most advanced assets, BI-1808 (anti-TNFR2) and BI-1206 (anti-FcγRIIB), while pausing earlier programs to maximize the probability of success and near-term value creation."- Martin Welschof, CEO BioInvent. EVENTS IN THE FOURTH QUARTER (R) Promising early Phase 2a monotherapy data for the company's lead anti-TNFR2 antibody BI-1808 in T-cell lymphoma (TCL) presented at ASH 2025 (R) Impressive response data from ongoing Phase 2a trial of triple combination of the company's lead anti-FcyRIIB antibody BI-1206, rituximab, and Calquence® in r/r non-Hodgkin's Lymphoma (NHL) presented at ASH 2025 Phase 2a trial started evaluating BI-1206 in combination with pembrolizumab in treatment-naïve advanced or metastatic non-small cell lung cancer (NSCLC) and uveal melanoma Orphan Drug Designation from EMA for BI‑1808 for the treatment of cutaneous T-cell lymphoma (CTCL) Phase 1 data of the company's second anti-TNFR2 antibody BI-1910 (currently paused) presented at SITC 2025 validates TNFR2 as a novel immunotherapy approach in advanced solid tumors Transgene and BioInvent presented translational data and updated clinical results on armed oncolytic virus BT-001 at ESMO 2025 BioInvent announced publication of preclinical and early clinical data for BI-1607 in HER2-positive advanced solid tumors EVENTS AFTER THE END OF THE PERIOD (R) Promising data in ongoing Phase 2a study for BI-1808 with KEYTRUDA® (pembrolizumab) for the treatment of recurrent ovarian cancer Updated clinical data sets solidify potential for both BI-1808 and pembrolizumab combination in ovarian cancer and BI-1206 triplet for the treatment of NHL, see pages 6 and 7 in the year-end report Nomination of two new board members ahead of 2026 Annual General Meeting; Kate Hermans and Scott Zinober EARLIER DURING 2025, IN BRIEF (R) Positive initial efficacy data from Phase 2a trial of triple combination of BI-1206, rituximab and Calquence® for the treatment of NHL BioInvent achieved ISO 26000 Verification, highlighting commitment to ESG and transparency (R) Promising Phase 2a monotherapy data for BI-1808 in CTCL presented at EHA 2025 Promising Phase 1 data of BI-1206 in combination with KEYTRUDA® (pembrolizumab) in solid tumors announced (R) XOMA Royalty purchased mezagitamab royalty and milestone rights held by BioInvent for up to USD 30 million Composition of matter patents for BI-1808 granted in US and Japan. They also cover the use of the antibody in the treatment of cancer FDA Fast Track Designation received for BI-1808 for the treatment of CTCL BI-1808 received Orphan Drug Designation from FDA for the treatment of TCL Strategic changes in portfolio to accelerate lead clinical programs and enhance value creation (R)= Regulatory event FINANCIAL INFORMATION Fourth quarter 2025 • Net sales SEK 3.0 (21.4) million • Profit/loss after tax SEK -125.8 (-116.9) million • Profit/loss after tax per share before and after dilution SEK -1.91 (-1.78) • Cash flow from operating activities SEK-90.6 (-98.3) million January - December 2025 • Net sales SEK 226.5 (44.7) million • Profit/loss after tax SEK -332.9 (-429.4) million • Profit/loss after tax per share before and after dilution SEK -5.06 (-6.53) • Cash flow from operating activities SEK -247.8 (-380.5) million • Liquid funds, current and long-term investments as of December 31, 2025: SEK 592.7 (867.2) million The complete interim report is available for download below and on the company's website under Financial reports . INVITATION TO PRESENTATION OF THE YEAR-END REPORT 2025 BioInvent's CEO Martin Welschof will present the report together with CFO Stefan Ericsson. The presentation will be held in English. When: Thursday February 26, 2026, at 2:00 pm CET The webcast can be reached at . If you wish to ask questions and participate via telephone, please register at the link below. After registration you will be provided with a phone number and a conference ID to access the conference. . The conference call will be made available on the company website after the call. About BioInvent BioInvent International AB (Nasdaq Stockholm: BINV) is a clinical-stage biotech company that discovers and develops novel and first-in-class immuno-modulatory antibodies for cancer therapy, with drug candidates in ongoing clinical programs in Phase 1/2 trials for the treatment of hematological cancer and solid tumors. The Company's validated, proprietary F.I.R.S.T ™ technology platform identifies both targets and the antibodies that bind to them, generating many promising new immune-modulatory candidates to fuel the Company's own clinical development pipeline and providing licensing and partnering opportunities. The Company generates revenues from research collaborations and license agreements with multiple top-tier pharmaceutical companies, as well as from producing antibodies for third parties in the Company's fully integrated manufacturing unit. More information is available at . For further information, please contact: Cecilia Hofvander, VP Investor Relations Phone: +46 (0)46 286 85 50 Email: cecilia.hofvander@bioinvent.com BioInvent International AB (publ) Co. Reg. No.: 556537-7263 Visiting address: Ideongatan 1 Mailing address: 223 70 LUND Phone: +46 (0)46 286 85 50 Attachments BioInvent Q4, 2025 EN Final SOURCE: BioInvent International View the original press release on ACCESS Newswire

临床结果孤儿药临床2期免疫疗法临床1期

2026-02-23

·BioSpace

BioInvent Announces Nomination of Two New Board Members Ahead of 2026 Annual General Meeting

Kate Hermans: Global life sciences executive with 25+ years of leadership across biopharma, commercial strategy, global operations, and value-creation transformations in both public and venture-backed companies Scott Zinober: Senior investment professional with 25 years global experience with focus on public companies, including two decades as senior portfolio manager at Viking Global Investors LUND, SE / ACCESS Newswire / February 23, 2026 / BioInvent International AB ("BioInvent") (Nasdaq Stockholm:BINV)(STO:BINV), a biotech company focused on the discovery and development of novel and first-in-class immune-modulatory antibodies for cancer immunotherapy, today announced the nomination of. Kate Hermans and Scott Zinober as new members of the Board of Directors. Their elections will be put forward for shareholder approval at the Annual General Meeting (AGM) on April 29, 2026. While the formal notice to the AGM will be published in March, BioInvent is pleased to share these nominations in advance given the strategic, operational, and financial leadership both candidates bring to the Company. "We are delighted to nominate Kate Hermans and Scott Zinober to the BioInvent Board," said Leonard Kruimer, Chairman of the BioInvent Board of Directors. "Kate brings valuable global operating experience and a track record of transforming and accelerating growth across biopharma organizations. Her commercial, strategic, and leadership experience will benefit BioInvent as our pipeline matures toward late-stage development and commercialization. Scott's experience in global healthcare investment and especially US capital markets insights will be key to developing viable financing strategies for the company going forward. As prospective new board members Kate's and Scott's experience in healthcare will broaden the board capabilities as we execute on our clinical strategy, advance our lead clinical candidates BI-1808 and BI-1206, and strengthen BioInvent's position as a global immuno-oncology innovator." Kate Hermans Kate Hermans is an accomplished global executive with more than 25 years of leadership experience across large enterprises and venture-backed biotechs, with multiple successful exits. Passionate about advancing high-science medicines and high-tech solutions that improve patients' lives, she is recognized for her commercial agility and ability to unlock potential through creative, often nonlinear approaches. As Interim CEO and President of Ambrx Biopharma, she drove a transformation that doubled the cash runway and positioned the company for its $2 billion acquisition by Johnson & Johnson in 2024. She previously held senior roles at 83bar LLC, Radius Health, Bristol Myers Squibb, Pfizer/Wyeth, and Intel, and brings extensive board leadership experience. Kate Hermans has attended advanced executive education through the CEDEP International General Management Program at INSEAD in Fontainebleau, France;.She holds a Master's in International Management with concentrations in Finance and Global Management from the Thunderbird School of Global Management; and earned a Bachelor's degree Magna Cum Laude in International Relations from Wheaton College, including program at the Institut d'Études Politiques (Sciences Po) in Paris. Board Chair of Clue, a leader in the FemTech space. Scott Zinober Scott Zinober is a senior investment leader with more than 25 years of global public and private equity experience, including two decades at Viking Global Investors. At Viking, he served as Healthcare Analyst, Portfolio Manager, Senior Portfolio Manager, and Team Leader overseeing both public and private healthcare portfolios. His responsibilities included investment strategy, therapeutics diligence, team leadership, and value creation across the biotechnology, pharma, and healthcare ecosystem. Scott Zinober also served on Viking's Investment Steering Committee, Management Committee, and the Viking Foundation Board. Earlier in his career, he focused on biotechnology investments at Putnam Investments. He holds an MBA from the MIT Sloan School of Management and a BA in Economics & Psychology from Williams College. Board members not up for reelection The existing Board Members Laura Lassouw-Polman, Kristoffer Bissessar and Thomas Hecht have declined re-election at the AGM on April 29, 2026. About BioInvent BioInvent International AB (Nasdaq Stockholm:BINV) is a clinical-stage biotech company that discovers and develops novel and first-in-class immuno-modulatory antibodies for cancer therapy, with drug candidates in ongoing clinical programs in Phase 1/2 trials for the treatment of hematological cancer and solid tumors. The Company's validated, proprietary F.I.R.S.T ™ technology platform identifies both targets and the antibodies that bind to them, generating many promising new immune-modulatory candidates to fuel the Company's own clinical development pipeline and providing licensing and partnering opportunities. The Company generates revenues from research collaborations and license agreements with multiple top-tier pharmaceutical companies, as well as from producing antibodies for third parties in the Company's fully integrated manufacturing unit. More information is available at . For further information, please contact: Cecilia Hofvander, VP Investor Relations Phone: +46 (0)46 286 85 50 Email: cecilia.hofvander@bioinvent.com BioInvent International AB (publ) Co. Reg. No.: 556537-7263 Visiting address: Ideongatan 1 Mailing address: 223 70 LUND Phone: +46 (0)46 286 85 50 Attachments BioInvent Announces Nomination of Two New Board Members Ahead of 2026 Annual General Meeting SOURCE: BioInvent International View the original press release on ACCESS Newswire

高管变更并购

100 项与 BI-1808 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
晚期癌症	临床2期	美国	BioInvent International AB	2021-01-25
晚期癌症	临床2期	丹麦	BioInvent International AB	2021-01-25
晚期癌症	临床2期	匈牙利	BioInvent International AB	2021-01-25
晚期癌症	临床2期	俄罗斯	BioInvent International AB	2021-01-25
晚期癌症	临床2期	西班牙	BioInvent International AB	2021-01-25
晚期癌症	临床2期	瑞典	BioInvent International AB	2021-01-25
晚期癌症	临床2期	英国	BioInvent International AB	2021-01-25
皮肤T细胞淋巴瘤	临床2期	美国	BioInvent International AB	2021-01-25
皮肤T细胞淋巴瘤	临床2期	丹麦	BioInvent International AB	2021-01-25
皮肤T细胞淋巴瘤	临床2期	匈牙利	BioInvent International AB	2021-01-25

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临床结果

适应症

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04752826 (Company_Website) 人工标引	临床2期	复发性卵巢癌	17	BI-1808 + KEYTRUDA	鹹構觸夢繭鬱齋構製艱(獵鬱蓋憲遞廠齋艱夢蓋) = 鬱鑰醖遞網獵廠壓遞蓋鹽遞鬱鏇選繭夢選淵蓋 (夢淵艱窪築遞餘遞鏇鏇 ) 更多	积极	2026-01-05
NCT04752826 (Company_Website) 人工标引	临床2期	皮肤T细胞淋巴瘤	8	BI-1808	衊製憲顧觸齋範積獵觸(鹹廠衊襯餘簾衊醖鏇繭) = 蓋蓋範積製網網繭簾齋遞憲顧願蓋廠繭廠繭齋 (夢艱窪衊齋糧壓餘鑰鹽 ) 更多	积极	2025-05-14
PF961 (EHA2025)	临床2期	皮肤T细胞淋巴瘤 TNFR2	20	BI-1808	顧壓衊範築製製製艱壓(簾窪衊廠顧廠醖鬱餘廠) = Disease “flares” characterized by increased skin peeling, erythema, and pruritis) were observed during first weeks of treatment in several cases, considered related to immune activation associated with depletion of T reg and influx of CD8+ T cells 鹹鹽構糧構醖廠簾遞網 (範糧網壓醖艱鑰網願壓 ) 更多	积极	2025-05-14
NCT04752826 (SITC2023)	临床1/2期	-	24	BI-1808	夢鏇襯襯憲蓋顧淵壓襯(憲鬱鹹顧積範願選選艱) = no Grade 3/4 AEs, AEs related to BI-1808 and no DLTs were observed 選顧積顧夢襯觸獵鹽積 (膚鏇窪艱齋觸積願艱鹽 ) 更多	积极	2023-11-02