预约演示
更新于：2026-09-08
Sodium Fusidate
夫西地酸钠
更新于：2026-09-08
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1972-04-22), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、合格传染病产品 (美国) |
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结构/序列
分子式C31H48NaO6 |
InChIKeyZUMDNSFJFSGPGY-JCJNLNMISA-N |
CAS号751-94-0 |
关联
22
项与 夫西地酸钠 相关的临床试验TCTR20260515003
The Effect of Petroleum Jelly and Fucidin Cream on the Healing Process of Patients with Partial-Thickness Burns: Randomized Controlled Trial
NCT05624359
Flurbiprofen Axetil as an Adjuvant to Pre-emptive Scalp Infiltration for Post-craniotomy Pain
NCT05641298
A Phase 2, Randomized, DB, Placebo-controlled Study to Determine the Efficacy, Safety and PK Profile of ARV-1801 in Combination With Optimized Background Therapy for the Treatment of Pulmonary Exacerbations in Patients With Cystic Fibrosis
100 项与 夫西地酸钠 相关的临床结果
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100 项与 夫西地酸钠 相关的转化医学
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100 项与 夫西地酸钠 相关的专利（医药）
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2,734
项与 夫西地酸钠 相关的文献（医药）2026-06-01The international journal of lower extremity wounds
The Influence of Honey and Hydrogel Products Therapy on Healing Time in Diabetic Foot
Article
作者: Al-Goshae, Husni Ahmed ; Al-Shubrumi, Hamad Saleh ; Badahdah, Hani ; Searan, Wael Mahmoud ; Abdalqader, Mohammed A. ; Nor, Hamdan Mohammed
Background:
Diabetic foot ulcer is a serious and common complication of diabetes that often leads to significant morbidity and even amputation if not properly treated. Current treatment options, such as wound dressing, have limitations in promoting efficient healing. There is a need for effective interventions that can expedite the healing process and enhance the time required for complete healing.
Methodology:
This prospective single-blinded randomized control trial studied diabetic mellitus type 2 patients with ulcer in their second-degree feet from February 2019 to February 2023 in the Diabetic Foot Center, King Fahad Specialist Hospital Al Qassim-KSA.
Results:
This study involved 120 patients with a mean age of 59.64 ± 10.21. And 63% to 52.5% of them were males and 57% to 47.5% were females. The mean healing time was about 12.76 ± 4.08 days. Cases were divided into 4 equal groups with altered treatment procedures: honey alone, hydrogel alone, honey, and hydrogel combination alternately (3 intervention groups), and fucidin ointment or cream alone (1 control group), with 30 participants in each group. We revealed that the mean healing times for honey alone, hydrogel alone, and honey and hydrogel alternately were 12.20, 13.97, and 10.83 days, respectively. While it was 14.03 days in the control Fucidin ointment or cream [significantly
P
< .05 (
P
= 0.04)].
Conclusion:
From the findings of the present study, we noticed that faster healing time among diabetic foot cases could be accomplished by treatment with a combination of honey and hydrogel alternately. Therefore, this therapy is effective in reducing the risk of diabetic foot ulcers.
2026-05-08ACS Pharmacology & Translational Science
Comparative Evaluation of Gold Nanoparticles, Extracts, and Topical Formulations Prepared with
Eruca sativa
: Toxicity and Wound Healing Effects
Article
作者: Hazbar, Abdullah Muhsin ; Baqi, Younis ; Jassim, Abdulkadir Mohammed Noori ; Mohammed, Mustafa Taha
Gold nanoparticles (AuNPs) hold promise for the therapy of cancer and inflammatory conditions. Here, we describe the preparation and evaluation of novel creams obtained from AuNPs prepared with Eruca sativa for capping ("green nanoparticles", termed Es-AuNPs) and E. sativa leaf powder (Es), a plant that is known for containing anti-inflammatory constituents. Es-AuNPs, E. sativa extract, powder, and topical formulations (Es-AuNPs and Es) were investigated in vitro and in vivo. GC-MS analysis of the plant extract revealed the presence of bioactive phytochemicals that likely contribute to its bioactivities. Acute toxicity studies showed no mortality in Wistar rats; however, a dose-dependent hepatotoxicity was observed for Es-AuNPs, while E. sativa extract was not hepatotoxic. Determination of the total oxidant status (TOS) for E. sativa extract and low-dose Es-AuNPs showed a reduced oxidant parameter, which was, however, elevated at a high dose of Es-AuNPs, indicating a dual antioxidant/pro-oxidant role. Measurement of the total antioxidant capacity (TAC) revealed a nonsignificant pattern. The newly formulated creams were tested in wound-healing assays in mice to assess their anti-inflammatory activity versus paraffin (negative control) and Fucidin (a standard steroid antibiotic). Applying Es-AuNPs and E. sativa powder creams (1% w/w) promoted injured tissue regeneration, decreased inflammation, and facilitated epithelial repair. These findings suggest promising therapeutic effects of Es-AuNPs and E. sativa powder-containing creams in skin inflammation management.
2026-04-01Open Veterinary Journal
Superior efficacy of 2% Olea europaea leaf extract ointment compared with Fucidin® in accelerating wound closure and resolving infection in rat models.
Article
作者: Kabbashi, Ahmed Saeed ; Shhome, Shahd Ezedeen Al ; Daikh, Nehal Moftah Al ; Amrajaa, Yasmeen Nouh ; Rages, Noor Al Houda Nasser ; Shailabi, Taher Issa ; Jabullah, Bushray Salih ; Bosallom, Shimaa Osama ; Bokhairallah, Namarq Moftah
Background:
Impaired wound healing, intensified by microbial infection and increasing antibiotic resistance, underscores the urgent need for novel therapeutic agents. Olea europaea L. (olive) leaf, which is rich in bioactive polyphenols, is a promising candidate for its traditional medicinal use.
Aim:
This study aimed to evaluate the wound-healing efficacy of a topical O. europaea leaf extract (OLE) ointment in clean and infected wound models by directly comparing its performance with that of a standard topical antibiotic.
Methods:
The phytochemical characterization and in vitro antibacterial activity of 75% ethanolic OLE were assessed. Ointments containing 1% and 2% (w/w) OLE were developed and characterized physicochemically. Their efficacy was evaluated in vivo using full-thickness excisional wounds in rats and compared with untreated, vehicle, and Fucidin®-treated controls. Wound models infected with Staphylococcus aureus and Pseudomonas aeruginosa were also established. Wound closure was monitored planimetrically for 21 days.
Results:
OLE was rich in phenols, flavonoids, and tannins and exhibited potent in vitro antibacterial activity against both pathogens, showing superior inhibition of S. aureus compared with that of Fucidin®. In the clean-wound model, 2% OLE ointment induced the most rapid healing, achieving complete closure by day 13, significantly outperforming Fucidin® (day 18; p < 0.01). In the infected models, both OLE ointments significantly accelerated healing and infection resolution compared with the controls. Notably, the 1% OLE formulation demonstrated superior early activity in infected wounds, reaching 100% closure by days 12 (S. aureus) and 13 (P. aeruginosa), while outperforming Fucidin® (days 18-20).
Conclusion:
The 2% OLE ointment possesses potent dose-dependent wound-healing and broad-spectrum antimicrobial activities, outperforming a standard antibiotic in clean wounds and showing high efficacy in infected models. Its multi-target action, derived from a complex phytochemical profile, validates its traditional use and highlights its potential as a leading natural formulation for advanced wound management, particularly in the era of antimicrobial resistance.
100 项与 夫西地酸钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 加拿大 | 1984-01-01 | |
| 继发感染 | 日本 | 1972-04-22 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 骨和关节感染 | 临床3期 | 美国 | 2015-12-01 | |
| 蜂窝织炎 | 临床3期 | 美国 | 2015-11-01 | |
| 硬结红斑 | 临床3期 | 美国 | 2015-11-01 | |
| 肺囊性纤维化 | 临床2期 | 美国 | 2023-02-10 | |
| 类鼻疽 | 临床2期 | 泰国 | 2022-06-14 | |
| 假体关节感染 | 临床2期 | 美国 | 2012-12-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2/3期 | 30 | 廠鹹繭願艱選觸衊築壓 = 鹹憲膚齋鏇積夢醖襯餘 觸窪願糧鏇鑰憲網願獵 (製鏇壓艱窪夢襯糧衊鏇, 膚襯積選遞鏇窪餘廠製 ~ 鹽醖襯顧壓襯築鑰範憲) 更多 | - | 2020-01-30 | |||
临床3期 | 716 | Fusidic acid | 餘簾廠壓鬱顧衊鏇繭鹹(網遞鏇艱鏇鹽窪鏇鏇選) = 繭願鑰衊選襯蓋簾遞觸 觸遞簾鏇醖膚鏇鏇餘鹹 (獵衊糧觸獵獵鬱獵簾顧 ) 更多 | 非劣 | 2017-02-24 | ||
餘簾廠壓鬱顧衊鏇繭鹹(網遞鏇艱鏇鹽窪鏇鏇選) = 繭廠淵鹹艱夢簾醖壓醖 觸遞簾鏇醖膚鏇鏇餘鹹 (獵衊糧觸獵獵鬱獵簾顧 ) 更多 | |||||||
临床4期 | 58 | (Fucidin® Cream) | 遞襯鏇願襯範積廠蓋壓 = 襯淵鹽糧膚衊積顧築壓 艱淵網窪網廠醖鏇觸積 (願選糧繭憲糧鹹鑰醖鏇, 簾構鹽繭壓範憲餘鬱蓋 ~ 餘襯醖廠網選襯憲醖鬱) 更多 | - | 2010-09-29 | ||
(Fucidin® Cream Vehicle) | 遞襯鏇願襯範積廠蓋壓 = 顧襯淵蓋鏇膚壓淵蓋醖 艱淵網窪網廠醖鏇觸積 (願選糧繭憲糧鹹鑰醖鏇, 觸製鏇築夢艱構夢鏇網 ~ 膚網獵繭繭膚鏇願築窪) 更多 |
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