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更新于：2026-04-03
Droxidopa
屈昔多巴
更新于：2026-04-03
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1989-01-17), |
最高研发阶段(中国)批准上市 |
特殊审评加速批准 (美国)、孤儿药 (美国)、快速通道 (美国) |
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结构/序列
分子式C9H11NO5 |
InChIKeyQXWYKJLNLSIPIN-JGVFFNPUSA-N |
CAS号23651-95-8 |
关联
44
项与 屈昔多巴 相关的临床试验NCT07398508
Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease: Double-blind Placebo-controlled Randomized Crossover Clinical Trial.
This clinical trial will evaluate the safety, tolerability, dosing, and efficacy of Northera (Droxidopa) in children with Menkes disease aged 7 to 17 years who survived the major neurodegenerative and neurocognitive effects of Menkes disease through early Copper Histidinate treatment. The investigator hypothesizes that Northera (Droxidopa) treatment in pediatric Menkes disease survivors with symptoms of dysautonomia (e.g., syncope, dizziness, orthostatic hypotension, abnormal sinoatrial conduction, and bowel or bladder dysfunction) from deficiency of the cuproenzyme, dopamine-beta-hydroxylase, will be safe and will correct or improve blood neurochemical levels, raise systolic blood pressure, and produce symptomatic improvement and a better quality of life. The investigator will test this hypothesis, in six to ten child or adolescent Menkes disease survivors through a placebo-controlled trial to evaluate adverse event rates and whether oral administration of Northera (Droxidopa) at doses established for individual subjects by careful dose titration improves plasma norepinephrine and dihydroxyphenylglycol (DHPG) levels, raises systolic blood pressure, and improves performance on tests of physical exertion. As an exploratory outcome measure, the study will validate the Orthostatic Hypotension Symptom Assessment (OHSA) questionnaire for this population for two four-week periods of either active or placebo treatment.
Aim 1. Determine the safety of Droxidopa in Menkes disease pediatric survivors.
Aim 2. Determine the efficacy of Droxidopa in Menkes disease survivors. The investigator hypothesizes that low-dose Droxidopa treatment in classic Menkes disease survivors aged 7 to 17 will improve orthostatic hypotension and ameliorate other signs and symptoms of dysautonomia. This pilot study will employ an ascending dose paradigm in a double-blind placebo-controlled randomized crossover design to optimize statistical power and rigorously discern treatment effects on 1) tilt table tests of orthostatic hypotension, 2) systolic and diastolic blood pressure, 3) plasma neurochemical levels and 4) tests of physical exertion. The trial will also validate the Orthostatic Hypotension Symptom Assessment (OHSA) questionnaire for this population of children and adolescents. This study addresses an important unmet clinical need for subjects with a rare disease, Menkes disease.
Aim 1. Determine the safety of Droxidopa in Menkes disease pediatric survivors.
Aim 2. Determine the efficacy of Droxidopa in Menkes disease survivors. The investigator hypothesizes that low-dose Droxidopa treatment in classic Menkes disease survivors aged 7 to 17 will improve orthostatic hypotension and ameliorate other signs and symptoms of dysautonomia. This pilot study will employ an ascending dose paradigm in a double-blind placebo-controlled randomized crossover design to optimize statistical power and rigorously discern treatment effects on 1) tilt table tests of orthostatic hypotension, 2) systolic and diastolic blood pressure, 3) plasma neurochemical levels and 4) tests of physical exertion. The trial will also validate the Orthostatic Hypotension Symptom Assessment (OHSA) questionnaire for this population of children and adolescents. This study addresses an important unmet clinical need for subjects with a rare disease, Menkes disease.
开始日期2026-06-01 |
申办/合作机构 |
NCT06937307
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems while in the hospital. When someone with cirrhosis experiences kidney injury, having better blood pressure can help their kidneys recover. Droxidopa is an oral medication that may help raise blood pressure without requiring intensive care or invasive treatments. The study will compare droxidopa to a placebo (inactive pill) in 75 people hospitalized with cirrhosis and kidney injury. Participants will take either droxidopa or placebo pills for 28 days and be monitored for an additional 30 days. Researchers will measure changes in blood pressure and kidney function to determine if droxidopa is effective and safe for these patients. This research could identify a new treatment option for a serious complication of liver disease.
开始日期2025-05-27 |
申办/合作机构 |
NCT03446807
Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism
The purpose of this study is to determine the efficacy of Droxidopa for the treatment of fatigue in patients with Parkinsonism by the Visual Analog Fatigue Scale (VAFS). This is a randomized, placebo-controlled, double-blind clinical trial for 3 months where half the subjects will receive placebo and the other half will receive Droxidopa. Following this will be a wash-out period of 7 days and then all subjects will receive Droxidopa for 3 months during the open-label phase.
开始日期2021-12-01 |
申办/合作机构 |
100 项与 屈昔多巴 相关的临床结果
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100 项与 屈昔多巴 相关的转化医学
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100 项与 屈昔多巴 相关的专利（医药）
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515
项与 屈昔多巴 相关的文献（医药）2026-05-01·JOURNAL OF MOLECULAR GRAPHICS & MODELLING
Evaluating the interactions of L-DOPA and droxidopa toward D
3
dopamine receptor through computational study: A comparison with dopamine
Article
作者: Baro, Bhabesh ; Sarkar, Biplab
The D3 dopamine receptor (D3R), a member of the G protein-coupled receptor family, plays a critical role in neurophysiological processes and has emerged as a potential target for treating neurological disorders such as Parkinson's disease. In this study, we employed computational approaches to investigate the molecular interactions of D3R with dopamine and two key dopamine precursors: L-DOPA and droxidopa. Molecular docking was conducted to evaluate binding affinities and identify key receptor-ligand interactions, followed by molecular dynamics simulations to assess the stability and dynamic behavior of the complexes in a biological environment. MM-PBSA binding free energy calculations were used to further quantify the strength of ligand binding to D3R.
2026-03-04·JOURNAL OF PHARMACY PRACTICE
Oral Agents for the Treatment of Refractory Hypotension in the Acute Care Setting - A Narrative Review.
Review
作者: Gibson, Gabrielle A ; Pouliot, Jonathon D ; Lista, Annette D
Refractory hypotension is a common occurrence in the acute care setting and is associated with a variety of conditions and underlying disease states. Persistent hypotension is associated with negative outcomes including organ failure and mortality. While initial management of hypotension often involves parenteral agents such as vasopressors, long term use is not desirable or feasible in many cases. The use of oral agents for refractory hypotension in the acute care setting gives providers options in these clinical scenarios, specifically vasopressor weaning, intradialytic hypotension, and orthostatic hypotension. Common agents used for refractory hypotension include droxidopa, fludrocortisone, midodrine, pseudoephedrine, and pyridostigmine. The use of midodrine has been extensively studied in the setting of vasopressor weaning with no clear benefit to its use, however smaller studies and case reports indicate pseudoephedrine may be useful. In the setting of intradialytic hypotension, there are data to support the use of midodrine, however there are questions about the long-term safety of its use. Midodrine and fludrocortisone alone or in combination with each other has shown benefits in the treatment of refractory orthostatic hypotension as has the use of droxidopa. In this review, the literature evaluating the use of these oral agents for refractory hypotension is assessed with a particular focus on acute care management.
2026-02-13·ACS Pharmacology & Translational Science
Influence of Lipid Composition on Nonspecific Interactions of Serotonin with Model Membranes
Article
作者: Lee, Sunghee ; Gudyka, Jamie ; Rabadi, Amani ; Perla, Wilber ; Silverberg, Shakinah ; Poust, Christopher ; Ceja Vega, Jasmin ; Agosti, Mackenna ; Said, Jessica ; Mitchell, Joseph ; Andersen, Elizabeth ; Mazzo, Giovanna ; Ceja, Jacqueline
Serotonin is a monoamine neurotransmitter, which plays an important role in the development and functioning of the central nervous system. Recent biophysical studies reveal that nonspecific interactions between serotonin and lipid membranes significantly alter lipid bilayer properties, impacting synaptic function and plasticity. To better understand these critical interactions and their broader implications for neural function and pharmacology, we investigated the interactions of serotonin (at concentrations ranging from 1 to 40 mM) with model membranes prepared as droplet interface bilayers, liposomes, and supported bilayers. These membrane systems comprised single, binary, and ternary lipid mixtures, including pure DOPC, DOPC/DOPS (10:1 mol ratio), and DOPC/Sphingomyelin/Cholesterol (1:1:0.2 mol ratio). Our analysis employing various experimental techniques shows that the interaction of serotonin with lipid membranes of diverse compositions has overall nonspecific effects in (1) influencing the barrier properties of the lipid membrane, as demonstrated by increased water permeability compared to the control; (2) modifying the phase transition behavior, evidenced by decrease in the main phase transition temperature and reduction of the transition enthalpy; (3) perturbing the conformational ordering of lipid membranes, as indicated by the increase in specific Raman intensity ratio; and (4) reducing bilayer tension with increasing serotonin concentrations. Overall, membrane modifications increase with rising serotonin concentrations, plateauing at higher levels. Sensitivity to serotonin varies by lipid composition in the order: DOPC/DOPS ≈ DOPC/Sphingomyelin/Cholesterol > DOPC. Our experimental findings reveal that serotonin significantly alters membrane properties, particularly affecting neuronal membrane composition and lipid rafts, which are critical for membrane protein organization and signaling. These findings suggest that serotonergic drugs and pathological fluctuations in serotonin may influence signaling not only through classical receptor-mediated pathways, but also by altering the lipid-protein landscape of the membrane, with potential implications for drug efficacy, off-target effects, and the development of therapies that target membrane composition in serotonin-related disorders.
25
项与 屈昔多巴 相关的新闻（医药）2026-04-01
原发性低血压病是一种以持续性低血压（收缩压＜90 mmHg和/或舒张压＜60 mmHg，1 mmHg≈0.133 kPa）为特征的慢性循环系统疾病，其患病人群在国内、外青年体弱人群中尤为高发，可增加晕厥、跌倒及心脑缺血事件风险。现代医学治疗存在不良反应多、疗效单一等局限性，而中医药通过多靶点调节氧化应激及血管内皮功能紊乱展现出独特优势。文章系统梳理原发性低血压病的中医病因病机与证候规律，结合现代医学机制，重点探讨中医药通过调节氧化应激及血管内皮功能改善血压稳态的作用靶点。结合现代药理研究解析中药复方及针灸作用的分子通路，总结其通过调控超氧化物歧化酶（SOD）、一氧化氮（NO）/内皮素-1（ET-1）平衡等关键靶点改善血压稳态的循证依据，以期为开发低毒高效的中医药治疗方案及个体化精准医学策略提供理论支撑。
原发性低血压病属于慢性低血压范畴，根据世界卫生组织（WHO）/国际高血压学会（ISH）标准，患者静息状态下连续3次（非同日）测得收缩压低于90 mmHg或舒张压低于60 mmHg（1mmHg≈0.133 kPa），且排除继发性低血压（如药物性、内分泌疾病相关），并排除妊娠期、哺乳期等特殊生理状态，主要临床症状包括反复发作的心悸、眩晕、头痛、疲劳，严重时可出现黑矇或晕厥等，在中医领域归属于“心悸”“眩晕”“虚劳”等病范畴。中国第 3次血压抽样调查结果显示，男性和女性的低血压患病率分别为2.70%和7.36%。汪媛等于2004年进行横断面调查，计算得到中国成人原发性低血压病的发病率为1.9%，男性患病率为1.1%，女性患病率为2.6%。周嫔婷等于2008年对湖南地区人群原发性低血压病进行流行病学调查，结果显示，原发性低血压病总患病率为5.82%，其中女性患病率为7.69%，男性患病率为3.74%。2010—2012年全国成年血压普查结果显示，中国男性和女性的原发性低血压病的患病率分别为1.1%和3.2%。国外的原发性低血压病在人群中同样具有一定程度的流行。
近年来研究发现，原发性低血压病患者承受着一定的心理及经济负担，且与体位性晕厥、认知功能下降及心血管事件风险增加显著相关。同时氧化应激状态和血管内皮功能紊乱在其发生发展过程中起关键作用，两者对维持血管张力和血压稳态至关重要。现代医学治疗原发性低血压病的药物如盐酸米多君、甲硫酸氨苯哒嗪、屈昔多巴等，虽有一定疗效，但在应用中常引发皮肤瘙痒、皮疹、心悸、头痛、排尿异常、寒战及轻度躯体颤抖等不良反应，且易导致血压矫枉过正。相比之下，中医药治疗原发性低血压病不仅能改善患者临床症状，还可升高血压，发挥综合治疗效果。因此，本文系统梳理原发性低血压病的中医病因病机与证候规律，结合现代医学机制，以氧化应激和血管内皮功能紊乱为切入点，综述其在原发性低血压病中的病理作用及中医药治疗的作用机制，重点探讨中医药通过调节氧化应激及血管内皮功能改善血压稳态的作用靶点，以期为开发低毒高效的中医药治疗方案及个体化精准医学策略提供理论支撑。一、原发性低血压病的中医病因病机与辨证论治
1.1 中医病因病机 原发性低血压病属中医学“眩晕”“心悸”“虚劳”等范畴，其病因病机与禀赋不足、后天失养密切相关。先天禀赋薄弱或久病体虚，可致气血生化乏源；饮食不节、劳倦过度则损伤脾胃，中焦运化失司，清阳不升；情志失调、思虑过度暗耗心血，心失所养；年老肾亏或房劳过度，肾精不足，髓海空虚，均可导致气血阴阳失衡。气血两虚、清阳不升为其核心病机，病位主要涉及心、脾、肾三脏。气虚则推动无力，血虚则濡养失职，清阳不升则脑窍失荣，故见眩晕、乏力；心气不足、心血亏虚则心悸怔忡；肾精亏虚则腰膝酸软、耳鸣健忘。
1.2 中医辨证分型与证候规律 根据《中医内科常见病诊疗指南》及临床研究，将原发性低血压病常见证型归纳如下：1）气血两虚证：面色苍白，眩晕心悸，神疲乏力，舌淡苔薄，脉细弱。2）中气不足证：头晕目眩，气短懒言，食少便溏，舌淡胖有齿痕，脉沉弱。3）心脾两虚证：心悸健忘，失眠多梦，纳呆腹胀，舌淡苔薄，脉细缓。4）肾精亏虚证：头晕耳鸣，腰膝酸软，健忘早衰，舌红少苔，脉沉细。
证候分布规律：临床以气血两虚证及中气不足证为主，青年女性多兼肝郁血虚，老年患者常合并肾精亏虚。病程迁延者易见阴阳两虚，表现为畏寒肢冷与潮热盗汗并见，提示病情复杂化。
1.3 原发与继发性低血压的中医理论辨析
1.3.1 病因病机差异 原发性低血压病：多因先天不足或后天失养，以气血阴阳虚损为本，病机重在“虚”，病情日久属“因虚致实”，呈现“虚实夹杂”的状态。如《景岳全书》云“无虚不作眩”，强调正气亏虚为核心。
继发性低血压病：常继发于失血、脱水、心力衰竭、内分泌疾病（如肾上腺功能减退等）或药物副作用（如降压药过量等），病机属“虚实夹杂”。如失血致气随血脱，药毒损伤脾胃升清之能，其始动因素即为标实（瘀、痰、毒）与正虚并存。
1.3.2 辨证与治疗侧重 原发性低血压病：以补虚为要，兼以理气，治法涵盖益气升阳（补中益气汤）、养血安神（归脾汤）、填精补肾（左归丸）等，注重整体调摄。
继发性低血压病：需标本兼治，针对原发病因，在补益气血基础上，结合从营血分祛邪（如：化瘀通络、解毒利湿等）。如失血者急用独参汤固脱，药源性低血压则需调整用药并辅以健脾和胃。
1.3.3 预后转归 原发性低血压经中医药调治后，气血渐充则症状多可缓解；继发性者需解除原发病因，否则易反复发作，甚则转为厥脱危候。二、氧化应激与血管内皮功能紊乱在原发性低血压病中的交互作用
2.1 氧化应激在原发性低血压病中的特异性机制 氧化应激（OS）是指细胞内外氧化还原平衡失调，致使活性氧（ROS）和反应性氮（RNS）过量生成，进而引发一系列细胞损伤与炎症反应。正常机体维持着氧化-抗氧化的动态平衡，一旦超出氧化防御体系的还原能力，就会造成细胞膜脂质过氧化、蛋白质氧化以及脱氧核糖核酸（DNA）损伤，影响细胞功能和器官正常活动。在原发性低血压病中，氧化应激扮演着重要角色。原发性低血压病患者的氧化应激特征表现为ROS过度生成与总抗氧化能力（TAOC）下降。临床研究证实，原发性低血压病患者血清丙二醛（MDA）水平较健康对照组升高，而超氧化物歧化酶（SOD）活性降低。动物实验进一步揭示，原发性低血压病模型大鼠延髓头端腹外侧区（RVLM）的ROS累积通过抑制磷脂酰肌醇3激酶（PI3K）/蛋白激酶 B（Akt）/神经元型一氧化碳合酶（nNOS）通路，减少一氧化氮（NO）生成，导致交感神经张力失衡及外周血管阻力下降。
2.2 血管内皮功能紊乱的核心作用 血管内皮细胞是覆盖在血管壁内膜上的单层扁平细胞，其功能不仅是作为血管壁的物理屏障，更重要的是参与调控血管张力和局部血流。内皮细胞通过分泌NO、内皮素（ET）、前列腺素（PG）等调节因子，对维持正常血流动力学和血压水平起到关键作用。其中，NO是内皮细胞分泌的重要血管舒张因子，能直接作用于血管平滑肌细胞，促使其松弛，从而扩张血管、降低血管阻力，使血压保持在正常范围。当血管内皮功能紊乱时，NO释放减少或活性降低，会影响血管舒张能力，导致血压降低。内皮素-1（ET-1）还可通过参与肾小管水和盐的排泄、促进平滑肌收缩、调节交感神经活动、激活NO释放等途径调节体内血压。原发性低血压病患者血浆NO/ET-1比值较对照组降低，内皮依赖性血管舒张功能下降。转基因小鼠实验表明，ET-1过表达可通过内皮素受体B（EDNRB）介导的NO释放异常，诱发原发性低血压病的发生。
2.3 氧化应激与内皮功能的交互网络 ROS可通过激活核因子-κB（NF-κB）通路促进炎症因子[如肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）]释放，损伤内皮细胞紧密连接蛋白（如ZO-1等），增加血管通透性；同时，内皮功能紊乱加剧线粒体氧化磷酸化障碍，形成“氧化-炎症-内皮损伤”恶性循环（见图1）。因此，氧化应激和血管内皮功能紊乱在原发性低血压病发生机制中是相互影响、不可分割的关键环节。
图1 “氧化-炎症-内皮损伤”示意图Fig.1 Schematic diagram of “oxidation-inflammationendothelial injury”
注：图片使用 Biorender 绘制。ROS，活性氧；NF-κB，核因子-κB；TNF-α，肿瘤坏死因子-α；IL-6，白细胞介素-6；eNOS，内皮一氧化氮合酶；NO，一氧化氮；ET-1，内皮素-1；ATP，腺嘌呤核苷三磷酸；Glucose，葡萄糖；Pyruvate，丙酮酸；Acetyl-CoA，乙酰辅酶 A；Citrate，柠檬酸盐；α-KG，α-酮戊二酸；Succinyl-CoA，琥珀酰辅酶 A；Oxaloacetate，草酰乙酸；TCA cycle，三羧酸循环。三、中医药治疗原发性低血压病的作用机制
中医认为，原发性低血压病多因气血不足所致，长期患病可能发展为阴阳两虚。近年来，随着对中药成分及其作用机制的研究不断深入，输入中药静脉制剂、口服中药复方、加载中药单体及针灸疗法能够安全有效地提高原发性低血压病患者的血压水平、改善临床症状，且通过调节氧化应激、改善血管内皮功能方面的作用逐渐明晰。
3.1 中药疗效的分子机制 治疗原发性低血压病的中药静脉制剂中，参麦注射液、生脉注射液较为常用。一项单盲随机对照试验结果表明，生脉注射液是治疗原发性低血压病安全有效的药物，相关药理学研究结果显示其可能通过β-谷甾醇、人参皂苷Rh2等有效成分作用于TNF、IL-6、表皮生长因子受体（EGFR）、BDNF、半胱氨酸天冬氨酸蛋白酶-3（Caspase-3）等核心靶点，调控 PI3K/Akt、MAPK等信号通路，通过改善线粒体功能障碍等途径，抑制ET-1和NO过度生成、纠正ET-1/NO紊乱，保护血管内皮功能，改善血压。研究表明，参麦注射液可能通过人参皂苷Rf、麦冬二氢高异黄酮E、尿苷等有效成分作用于CYP3A4、NOS1、白细胞介素-1β（IL-1β）等核心靶点，进而激活网状内皮系统、改善微循环、兴奋垂体-肾上腺皮质系统、促进糖皮质激素分泌，同时抑制血管平滑肌Na+-K+ATP酶活性、影响Ca2+交换、增加Ca2+内流、增强心肌收缩力，进而改善血压。一项比较参芪扶正注射液与参麦注射液治疗原发性低血压病患者临床疗效的随机对照试验结果显示，参芪扶正注射液疗效优于参麦注射液，可能是因为前者能通过槲皮素、木犀草素、山柰酚等有效成分作用于AKT1、TNF、TP53、IL-6、ESR1等核心靶点，调控 PI3K/AKT、Toll样受体 4（TLR4）/NF-κB/Nod样受体蛋白 3（NLRP3）等多条信号通路来改善氧化应激及微炎症状态，更好地改善血流动力学指标和血管内皮功能，抑制心肌细胞膜上的Na+-K+ATP酶活性，使Ca2+内流增多，加强心肌收缩力且不增加心肌耗氧量，显著提高左室射血分数，纠正低血压。一项随机对照试验显示，参附注射液治疗女性原发性低血压疗效显著，其作用机制与改善血管内皮功能密切相关，可能通过 PTGS2、PTGS1、NCOA2、ADRB2等有效成分作用于 Akt、激活蛋白-1（AP-1）、p56等核心靶点，调控Ca2+、Toll样受体等信号通路，减轻内皮细胞表面的功能层多糖包被、保护血管内皮、抑制ET-1生成、降低炎性因子分泌，有效调节冠状动脉内皮功能，提高心脏收缩功能，从而升高血压。一项自身前后对照试验表明，口服炙甘草汤治疗原发性低血压病患者安全有效，其可能通过山柰酚，木犀草素，槲皮素等有效成分作用于INS、AKT1、丝裂原活化蛋白激酶（MAPK）3、IL-6等核心靶点，调控叉头框蛋白 O1（FOXO）、TNF、白细胞介素-17（IL-17）、Toll样受体等信号通路，干预血管内皮细胞，调节血管内皮功能发挥作用。除上述中药复方及其所含中药单体，吴茱萸中的脱氢吴茱萸碱被研究认为具有治疗头痛和改善血压的作用，其可能通过沉默信息调节因子 1（SIRT1）/FOXO3A/BIM通路改善机体氧化应激状态，调节线粒体功能，增强血管内皮生长因子的产生并上调紧密的连接蛋白，进而改善血管内皮功能发挥疗效。
3.2 针灸疗效的分子机制 一项随机对照试验结果显示，针刺星状神经节治疗原发性低血压病患者可升高血压、改善临床症状。其机制可能是物理刺激星状神经节降低MDA、ROS表达，提高SOD、过氧化氢酶（CAT）表达，减轻氧化应激，调节自主神经平衡，恢复交感-迷走平衡，进而调控外周去甲肾上腺素（NE）含量。此外，针灸也可通过改善血管内皮功能治疗原发性低血压病。黄建军等通过基础实验探索发现，电针刺激水沟、足三里两穴可特异性靶向调节心脏及肾脏的肾素-血管紧张素-醛固酮系统（RAAS），降低心钠素含量，提高ET水平，减少肾脏血流量，进而影响血管内皮功能调节，产生显著升压效应。四、病案举隅
患者,女,34岁,2022年4月6日初诊。主诉:头晕反复发作3年余,加重半个月。患者3年前因行剖宫产术中大出血后出现头晕。于当地医院就诊,测血压78/52 mm Hg(1 mm Hg≈0.133 k Pa),行颅脑CT检查无异常,诊断为低血压。3年来间断口服中成药天王补心丹,效不佳,头晕反复发作。半个月前因搬家劳累后头晕加重,特来就诊。既往有低血压病史。无其他慢性病、传染病、遗传病病史。无过敏史。现症见:阵发性头晕,甚至伴恶心,无视物旋转,活动后加重;平素常感疲劳,面色淡白,倦怠乏力,易患感冒,多汗,健忘,月经常推迟10 d左右,经量少,色淡;眠差易醒,醒则难以入睡;纳尚可,大便干,小便调;舌淡,苔薄白,脉细弱。刻下血压83/54 mm Hg。查体无异常。其他辅助检查均未见异常。西医诊断:低血压。中医诊断:眩晕(气阴亏虚证)。治宜益气补血、滋阴生脉。处方:红参10 g(单煎兑服),麦冬12 g,五味子6 g,柴胡6 g,枳实6 g,甘草片6 g,黄芪30 g,当归12 g,阿胶6 g(烊化冲服),酸枣仁15 g,大枣8枚。14剂,水煎,每日1剂,早晚饭后温服。
2022年4月20日二诊:服药后头晕明显改善,现患者仍偶感疲劳、乏力,口干眼干,喜多饮,大便干,面唇色淡,舌淡,苔薄白,脉细弱。刻下血压92/60 mm Hg。此诊患者气虚之症得以改善,阴血虚之症尚存,治宜滋阴养血,兼之补气。上方中红参改为6 g(单煎兑服),黄芪改为15 g,加熟地黄30 g,枸杞子15 g,白芍15 g。7剂,水煎,每日1剂,早晚饭后温服。
2022年4月27日三诊:服药后诸症皆减,现偶感头晕、乏力,口干,眠浅,多梦易醒,二便调。舌淡红,苔薄白,脉细。刻下血压98/64 mm Hg。此诊患者诸症好转,但仍眠差。治宜益气滋阴、养心安神。上方加柏子仁15 g,首乌藤15 g,制远志9 g,7 剂,水煎,每日1剂,早晚饭后温服。经随访,患者诸症皆除,后未再发作。
按语:患者因剖宫产术后出现眩晕,伴有乏力多汗,健忘,月经推迟且量少,乃因术中大出血、术后养护失宜、病程较长而出现的气阴亏虚之证。治疗宜采用益气生脉法。结合患者有大出血病史,重用当归、阿胶、大枣等以滋阴养血生精,黄芪配伍当归益气生血。所谓有形之血不能自生,乃无形之气生之,故用黄芪、麦冬、五味子以气阴双补、益气养阴;眠差易醒,故加酸枣仁助眠。二诊时,患者气虚症状得以缓解,阴血虚之症尚存,故减红参、黄芪用量,加熟地黄、枸杞子、白芍等滋阴养血。三诊时,患者眠差,故加柏子仁、首乌藤、制远志以宁心安神。诸药合用,益气生血,滋阴充脉,使气血得复,脉道充盈畅通,则眩晕自除。五、总结与展望
原发性低血压病患者常伴有血管内皮功能紊乱，致使血管舒缩能力失衡，影响血压稳定调节。在此过程中，氧化应激起着重要作用，过多自由基和氧化物质可损伤血管内皮细胞，加剧本病的病理进程。临床试验和基础实验研究已初步证实中医药在调节氧化应激和改善血管内皮功能方面的积极作用。本研究从“气血-清阳-脏腑”角度阐释原发性低血压病的中医病机，认为其核心在于气血两虚、清阳不升，病位主要涉及心、脾、肾三脏，与继发性低血压病的“虚实夹杂”始动因素（如瘀、痰、毒与正虚并存）形成鲜明对比。未来研究可进一步结合代谢组学等技术，探索不同证型的分子标志物，推动个体化治疗策略的优化。但当前研究存在以下局限：1）多数实验基于动物模型，临床转化证据不足；2）复方成分复杂，单体药效机制尚未完全明确；3）个体化治疗体系缺失。未来需结合多组学技术（如代谢组学、单细胞测序等）筛选原发性低血压病亚型特异性生物标志物，构建“辨证-靶向-预后”精准治疗模式，并利用人工智能算法优化针灸穴位配伍方案，有望实现原发性低血压病的个体化干预。
贾晓周（线上就医：18704099845)，毕业于河北医科大学，中西医结合、临床医学双学历，后于辽宁中医药大学附属医院进修，曾就职于辽宁航空航天附属医院，曾受聘于北京至道中医研究院任副院长，国家区域慢性呼吸系统病防治中心会诊专家（重庆）、《皇帝内经》东方哲学体系研究员、国家生活方式医学领域专家顾问，传统武式太极拳精英传承人，世界医疗健康管理协会会员，长年从事创新性医药领域及临床诊疗技术应用学术研究工作。
目前主要从事呼吸领域相关疾病临床诊疗进展、儿童生长发育及慢性骨病中西医联合诊疗领域科研工作，国内外先进特色诊疗技术挖掘及整理。曾参加中国咳嗽诊疗指南万里行巡讲，作为“气道炎症专场”特邀专家，2018年发起“中国基层咳嗽诊疗指南万里行”活动，2020年发起“中国基层儿童咳喘病全国巡讲”活动，2021年发起“中国基层慢病规范化诊治”全国巡讲活动，2023年新冠病毒感染及其并发症的临床规范化诊治方案更新，推进基层《新冠感染咳嗽专科门诊》、《呼吸慢病专科门诊》等专科门诊机构的建立，2025年进行关于儿童生长发育及慢性骨病中西医临床最新诊疗模式进展探究，深入研究“疏木六君子汤”“清肺汤等”在呼吸及相关肿瘤领域的应用进展，进一步提升最新生物制剂相关特效雾化治疗方案相关难治性、难愈性呼吸系统疾病治疗，推进基层“气道炎症计”呼出气一氧化氮精准化气道炎症水平测定及指导相关呼吸系统疾病中西医结合治疗方案。2026年致力于临床呼吸、消化及心脑血管常见慢病中西医结合MDT门诊建设工作，深入推进科研门诊与常规诊疗相结合的临床发展方向。立足于目前临床最新医学进展领域：阶梯式治疗方案、呼吸免疫治疗方案、上下气道同治治疗方案、精准化诊治治疗方案、常见病快速评估等及针对中西医结合临床一线指南推荐用药等做全面总结研究，以帮助更多的同仁完成科学、精准、规范的诊治，开展更多医疗领域学术交流会议，推进常见多发病的预防、科学的健康管理新理念。
2026-03-28
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今日答疑
大家好，这里是新开辟的「摸鱼问答室」栏目，回答各位病友在后台和群里问我的一些问题。
因为我本身也是SMA患者，不是医生，所以所有回答都是我个人搜集信息整理而来，不构成医疗建议，具体治疗请一定遵医嘱。
这次整理了五位病友问我的问题，都是比较少见的类型，一起来看看。
罕见病答疑
谷胱甘肽合成酶缺乏是什么病？有药吗？
回答：
谷胱甘肽合成酶缺乏（Glutathione synthetase deficiency）是一种非常罕见的常染色体隐性遗传病，会影响谷胱甘肽的合成。
主要临床表现：
可导致溶血性贫血
可能伴有神经系统问题
部分患者会出现代谢性酸中毒
因为非常罕见，具体症状因人而异
治疗现状：
这是一种遗传病，目前没有根治性药物
主要是对症治疗：
严重溶血时可能需要输血
纠正代谢性酸中毒
补充抗氧化剂帮助缓解症状
研究层面：基因治疗仍在早期探索阶段，没有进入临床
庞贝病现在有国产药进入临床试验了吗？
回答：
庞贝病（糖原累积病II型）是一种溶酶体贮积症，目前国内已经有进口酶替代疗法药物上市，但价格昂贵。
关于国产药：
目前国内研发进展：
北京锦篮基因 GC301
适应症：庞贝病
研发阶段：已经进入I期临床试验
技术路线：AAV基因治疗
这是目前国产庞贝病基因治疗走得比较靠前的项目
其他公司
还有一些药企在做酶替代疗法的生物类似药，但目前公开信息不多，进展相对较慢
已上市药物：
进口酶替代疗法（阿糖苷酶α等）已经纳入医保，虽然价格依然不低，但比以前好了很多
多系统萎缩病人现在有可用药物吗？
回答：
多系统萎缩（Multiple System Atrophy，MSA）是一种进行性的神经退行性疾病，目前还没有能够根治或者逆转疾病进程的药物。
现有治疗手段：
对症治疗为主：可以用药改善一些症状，比如改善体位性低血压、改善帕金森样症状
常用药物包括：屈昔多巴等可以帮助改善低血压，左旋多巴可能对部分患者的帕金森症状有一定帮助
这些都只是改善症状，不能阻止疾病进展
研发前沿：
目前有多个针对多系统萎缩的新药在临床试验阶段
国内也有药企在开展相应研究，但暂时还没有新药获批上市
可以关注一下你们当地的大型三甲医院神经内科，有没有临床试验招募，符合条件可以免费用药
建议：
虽然没有根治药物，但早期干预对症处理依然很重要，可以改善生活质量
康复锻炼对维持功能也有帮助
真性红细胞增多症、血小板增多症、骨髓纤维化？这些病有药吗？
回答：
这三个其实都属于骨髓增殖性肿瘤，我在这里整理一下：
这三种病目前都是有药可用的：
1. 真性红细胞增多症（PV）
一线治疗：羟基脲、干扰素
靶向药物：芦可替尼已经获批，也进入医保了
治疗效果整体不错，能很好控制病情
2. 原发性血小板增多症（ET）
一线治疗：羟基脲、阿司匹林、干扰素
也有靶向药物可选，总体控制效果好
3. 骨髓纤维化（MF）
靶向药物：芦可替尼、fedratinib等都已经在国内获批
部分患者符合条件可以考虑造血干细胞移植
新药研发也比较活跃，有多个新药在研
尼曼匹克C型，美国新药一个月要20多万吃不起，国内有前沿研发信息吗？
回答：
尼曼匹克C型（Niemann-Pick type C）是一种非常罕见的溶酶体贮积症，目前全球范围内药物选择都很少。
国外已上市药物：
美普特生（miglustat）：国内已经进口上市，但价格不便宜
芳基咪唑类药物（olipudase alfa，商品名Xenpozyme）：国外获批，国内尚未进口，确实价格非常昂贵，大概就是你说的一个月二十多万水平，普通家庭根本承受不起
Aqneursa（levacetylleucine）：2024年9月FDA刚刚批准，用于治疗C型尼曼匹克氏症相关神经系统症状，是近期获批的新药
国内目前的研发信息：
经过公开信息核查，目前国内没有找到公开进入临床阶段的国产尼曼匹克C型新药，公开信息比较少。
如果你想尝试，可以关注以下途径：
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2026-03-26
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截至03月26日15点59分，近期共有 552 本期刊发布了 1160 篇文章，其中糖尿病相关的文章共 310 篇，覆盖 26 个领域的内容。中国专家参与发表的文章有 84 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 Diabetes care IF: 16.600 美国新诊断1型糖尿病儿科患者中使用持续葡萄糖监测联合远程患者监测的成本效益
Dupenloup, Paul, Chen, Yupeng, Prahalad, Priya, Johari, Ramesh, Addala, Ananta, Zaharieva, Dessi P, etc.
近日，一项针对美国新诊断1型糖尿病儿科患者的研究评估了持续葡萄糖监测（CGM）联合远程患者监测（RPM）的成本效益。研究使用Markov模型模拟5岁患者未来20年、50年及终身的1型糖尿病进展，追踪糖尿病酮症酸中毒（DKA）、严重低血糖（SH）及7种慢性并发症（视网膜病变、神经病变等），并对比三种干预措施：自我血糖监测（SMBG）、单独CGM及CGM联合RPM。
研究效能数据来自儿科CGM研究荟萃分析及4T研究1结果，采用质量调整生命年（QALYs）和医疗成本（2022美元，3%年折现率）进行评估，同时开展广泛敏感性分析。结果显示，20年时间跨度内，与SMBG相比，CGM使QALYs增加0.09，医疗成本增加8900美元；而CGM联合RPM则进一步增加QALYs 0.37，成本增加10300美元。
从成本效益角度看，CGM联合RPM的增量成本效益比（27,400/QALY）显著低于单独CGM（103,700/QALY）。敏感性分析和不同时间跨度（20年、50年、终身）的结果均显示稳健性，当CGM联合RPM达到4T研究临床效能的至少30%时，仍保持成本效益。
研究结论认为，CGM联合RPM为美国新诊断1型糖尿病儿科患者带来的健康结局优于SMBG和单独CGM，且具有成本效益。尽管干预成本较高，但CGM联合RPM可降低并发症相关医疗成本，最终产生净医疗费用节省。
本文由 韩玉莲 编辑
扫描二维码查看源文
Diabetes care | Ahead of Print.
10.2337/dc25-2825
02 JAMA Cardiology IF: 14.100 口服司美格鲁肽对高危2型糖尿病患者心血管危险因素的改变影响：SOUL随机临床试验的事后次级分析
Sharon L. Mulvagh, Silvio E. Inzucchi, Nikolaus Marx, Neil R. Poulter, John E. Deanfield, Rodica Pop-Busui, etc.
JAMA Cardiology发表的SOUL随机临床试验事后二次分析显示，口服司美格鲁肽（每天一次，最大剂量14 mg）在高危2型糖尿病（T2D）合并动脉粥样硬化性心血管疾病（ASCVD）和/或慢性肾脏病（CKD）患者中，可早期及长期改善多个ASCVD危险因素。
该研究纳入9650例平均年龄66.1岁的患者，1:1随机分配至口服司美格鲁肽组或安慰剂组，联合标准治疗，随访156周。结果显示，98.4%的参与者完成试验，口服司美格鲁肽在13周内即出现显著改善：糖化血红蛋白（HbA1c）下降0.87个百分点，体重减轻2.54%，收缩压（SBP）降低3.84mmHg，脉压（PP）减少3.81 mm Hg，高敏C反应蛋白（hsCRP）下降18.08%，总胆固醇（TC）降低7.00%，非高密度脂蛋白胆固醇（non-HDL-C）降低8.02%，高密度脂蛋白胆固醇（HDL-C）降低4.49%，甘油三酯降低8.15%，且这些改善持续至156周。
在156周时，口服司美格鲁肽组的HbA1c较安慰剂组降低0.47个百分点（95%CI：-0.52~-0.42），体重减少3.26%（95%CI：-3.55~-2.98），SBP降低1.83 mm Hg（95%CI：-2.47~-1.18），PP降低2.17 mm Hg（95%CI：-2.72~-1.61）。血脂指标中，hsCRP（0.77；95%CI：0.74~0.81）、TC（0.99；95%CI：0.98~1.00）、non-HDL-C（0.98；95%CI：0.97~0.99）、HDL-C（1.01；95%CI：1.01~1.02）、甘油三酯（0.94；95%CI：0.93~0.96）均显著改善。研究未观察到低密度脂蛋白胆固醇（LDL-C）或舒张压（DBP）的显著差异。
该研究提示，口服司美格鲁肽作为高危T2D患者的治疗选择，可长期稳定改善心血管危险因素，安全性良好。
本文由 韩玉莲 编辑
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JAMA Cardiology | Ahead of Print.
10.1001/jamacardio.2026.0245
03 BMJ medicine IF: 10.000 2型糖尿病退伍军人中停用或中断胰高血糖素样肽-1受体激动剂治疗对主要不良心血管事件的持续时间依赖性影响
Xie, Yan, Choi, Taeyoung, Al-Aly, Ziyad, etc.
一项最新研究针对美国退伍军人事务部的2型糖尿病患者，分析了停用或中断胰高血糖素样肽-1受体激动剂（GLP-1RAs）治疗对主要不良心血管事件（MACE）的影响。
研究共纳入132,551例新使用GLP-1RAs的患者和201,136例新使用磺脲类药物的患者，中位随访3年。
结果显示，持续使用GLP-1RAs可显著降低MACE风险（与磺脲类相比，风险比0.87，95%CI 0.83-0.91），而停药或中断治疗对MACE风险的影响具有持续时间依赖性：停药0.5年、1年、≥1.5年的MACE风险比分别为1.04（95%CI 1.01-1.08）、1.14（95%CI 1.09-1.19）、1.22（95%CI 1.16-1.27）。中断治疗的风险梯度与停药类似但程度稍轻（中断0.5年：1.07，95%CI 1.03-1.12；中断1年：1.10，95%CI 1.05-1.15）
研究强调，维持GLP-1RAs治疗连续性是降低MACE风险的关键，中断或停药的持续时间越长，心血管风险增加越显著。
本文由 韩玉莲 编辑
扫描二维码查看源文
BMJ medicine | Volume 5, Issue 1
10.1136/bmjmed-2025-002150
中国发表（84）
China
Journal of Vascular Surgery IF: 03.600Volume 83, Issue 4No.01Hemoglobin A1c correlated with outcomes in diabetics after revascularization糖化血红蛋白与糖尿病患者血运重建术后的预后相关DOI: 10.1016/j.jvs.2025.10.097
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiVolume 42, Issue 3No.02[Clinical effects of antibiotic bone cement and VSD combined with free chimeric anterolateral thigh perforator myocutaneous flaps for sequential treatment of diabetic calcaneal osteomyelitis wounds]抗生素骨水泥联合VSD与游离嵌合股前外侧穿支肌皮瓣序贯治疗糖尿病跟骨骨髓炎创面的临床效果DOI: 10.3760/cma.j.cn501225-20251129-00493
Journal of controlled release IF: 11.500Ahead of Print.No.03Hydrogel-immobilized coacervate droplets enable microenvironment-responsive sustained drug release to accelerate diabetic foot ulcers healing水凝胶固定凝聚液滴实现微环境响应的持续药物释放，加速糖尿病足溃疡愈合DOI: 10.1016/j.jconrel.2026.114858
Pathology, research and practice IF: 03.200Ahead of Print.No.04Moist exposed burn ointment (MEBO) promotes healing of chronic diabetic wounds in rats by regulating inflammatory factors and autophagy湿润烧伤膏（MEBO）通过调节炎症因子和自噬促进大鼠慢性糖尿病创面愈合DOI: 10.1016/j.prp.2026.156448
Experimental gerontology IF: 04.300Ahead of Print.No.05Association of Dietary Inflammatory Index (DII) with cardiovascular and all-cause mortality in patients with Cardiovascular-Kidney-Metabolic (CKM) syndrome: a prospective cohort study饮食炎症指数(DII)与心血管-肾脏-代谢(CKM)综合征患者心血管及全因死亡率的关联：一项前瞻性队列研究DOI: 10.1016/j.exger.2026.113104
Fitoterapia IF: 02.600Ahead of Print.No.06Characterized polyphenols from Prunus cerasifera alleviated HFD-induced intestinal inflammation and barrier dysfunction in obese mice by remodeling the gut microbiota and short-chain fatty acid profile黑樱桃李特征化多酚通过重塑肠道菌群和短链脂肪酸谱减轻高脂饮食诱导的肥胖小鼠肠道炎症和屏障功能障碍DOI: 10.1016/j.fitote.2026.107203
Nutrition research IF: 03.100Ahead of Print.No.07Betaine inhibited adipogenesis in 3T3-L1 preadipocytes and alleviated obesity-related disorders in high-fat diet-fed C57BL/6 mice by modulating gut microbiota composition甜菜碱通过调节肠道菌群组成抑制3T3-L1前脂肪细胞的脂肪生成并缓解高脂饮食喂养的C57BL/6小鼠的肥胖相关疾病DOI: 10.1016/j.nutres.2026.02.008
J Pharmacol Exp Ther IF: 03.800Ahead of Print.No.08Drug-drug interactions of antidepressant ammoxetine mediated by cytochrome P450 2D6 and multidrug and toxin extrusion protein 1: From in vitro mechanistic investigations to in vivo validation抗抑郁药阿莫西汀通过细胞色素P450 2D6和多药及毒素外排蛋白1介导的药物相互作用：从体外机制研究到体内验证DOI: 10.1016/j.jpet.2026.104312
Am J Pathol IF: 03.600Ahead of Print.No.09Gpat3 knockout attenuates adipose loss and steatohepatitis in Agpat2-deficient miceGpat3基因敲除减轻Agpat2缺陷小鼠的脂肪流失和脂肪性肝炎DOI: 10.1016/j.ajpath.2026.02.009
Cellular signalling IF: 03.700Ahead of Print.No.10Lipid metabolic reprogramming of CD8(+) T cells in the tumor microenvironment肿瘤微环境中CD8(+) T细胞的脂质代谢重编程DOI: 10.1016/j.cellsig.2026.112496
Trends Endocrinol Metab IF: 12.600Ahead of Print.No.11Regulation of skeletal muscle mitochondrial fuel utilization during exercise运动中骨骼肌线粒体燃料利用的调节DOI: 10.1016/j.tem.2026.01.014
British journal of nutrition IF: 03.000Ahead of Print.No.12Association Between Saturated Fatty Acid Intake and MASLD: Mediating Roles of Insulin Resistance and Serum Albumin饱和脂肪酸摄入与代谢功能障碍相关脂肪性肝病的关联：胰岛素抵抗和血清白蛋白的介导作用DOI: 10.1017/S0007114526106990
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiVolume 42, Issue 3No.13[Medium- and long-term clinical efficacy of tibial transverse transport surgery in the treatment of diabetic foot ulcers]胫骨横向搬运术治疗糖尿病足溃疡的中远期临床有效性DOI: 10.3760/cma.j.cn501225-20241028-00417
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiVolume 42, Issue 3No.14[Role and mechanism of Wnt9a in human and mouse chronic wound healing]Wnt9a在人及小鼠慢性创面愈合中的作用及机制DOI: 10.3760/cma.j.cn501225-20241122-00457
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiVolume 42, Issue 3No.15[Comparison of the predictive efficacy of the Wagner, SINBAD, and WIfI grading systems for short-term wound non-healing and amputation in patients with DFUs]Wagner、SINBAD和WIfI分级系统对糖尿病足溃疡患者短期伤口不愈合及截肢的预测有效性比较DOI: 10.3760/cma.j.cn501225-20251129-00494
Journal of renal nutrition : IF: 03.200Ahead of Print.No.16Association of C-reactive protein-triglyceride glucose index with chronic kidney disease and reduction of renal functionC反应蛋白-甘油三酯-葡萄糖指数与慢性肾脏病及肾功能下降的关联DOI: 10.1053/j.jrn.2026.03.003
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiVolume 42, Issue 3No.17[Epidemiological characteristics of adult inpatients with diabetes-related chronic non-healing wounds in Hainan province]海南省成年住院患者糖尿病相关慢性难愈性伤口的流行病学特征DOI: 10.3760/cma.j.cn501225-20250606-00257
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiVolume 42, Issue 3No.18[Research advances on the targeted programmed cell death regulatory network for treatment of refractory diabetic wounds]针对难治性糖尿病创面的靶向程序性细胞死亡调控网络研究进展DOI: 10.3760/cma.j.cn501225-20251106-00460
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za ZhiVolume 42, Issue 3No.19[Mechanism of actions and reflections of Masquelet induced membrane technique in diabetic wound]Masquelet诱导膜技术在糖尿病创面中的作用机制及思考DOI: 10.3760/cma.j.cn501225-20251125-00487
Journal of Advanced Research IF: 13.000Ahead of Print.No.20Ginsenoside Rb1 attenuates diabetic peripheral neuropathy pathology by functioning as a potent activator of isocitrate dehydrogenase 1人参皂苷Rb1通过作为异柠檬酸脱氢酶1的强效激活剂减轻糖尿病周围神经病变病理DOI: 10.1016/j.jare.2026.03.055
International immunopharmacology IF: 04.700Ahead of Print.No.21Liquiritin attenuates IONI-induced trigeminal neuropathic pain via TLR4/MyD88-dependent modulation of microglial M1-like polarization甘草查尔酮A通过TLR4/MyD88依赖的小胶质细胞M1样极化调节减轻眶下神经损伤诱导的三叉神经病理性疼痛DOI: 10.1016/j.intimp.2026.116554
Nutrition research IF: 03.100Volume 148, Issue No.22Advantages of energy restriction approach in mitigating metabolic syndrome: A network meta-analysis能量限制方法在缓解代谢综合征中的优势：一项网状Meta分析DOI: 10.1016/j.nutres.2026.02.002
PloS one IF: 02.600Volume 21, Issue 3No.23A hemorheological perspective on coronary microvascular dysfunction: Association of erythrocyte parameters with angiography-derived coronary microcirculatory resistance从血液流变学角度探讨冠状动脉微血管功能障碍：红细胞参数与血管造影衍生的冠状动脉微循环阻力的关联DOI: 10.1371/journal.pone.0345562
Mol Cell Biochem IF: 03.700Ahead of Print.No.24Molecular characteristics of apolipoprotein M and its biological functions in kidney diseases载脂蛋白M的分子特征及其在肾脏疾病中的生物学功能DOI: 10.1007/s11010-026-05519-9
Cell reports IF: 06.900Ahead of Print.No.25SETDB2-mediated transcriptional repression of IDE in sensory neurons promotes migraine-like pain behaviors in miceSETDB2介导感觉神经元中IDE的转录抑制促进小鼠偏头痛样疼痛行为DOI: 10.1016/j.celrep.2026.117201
Nutrición hospitalaria IF: 01.100Ahead of Print.No.26The modifiable effect of TyG index and DI-GM on the associations between conventional risk factors and strokeTyG指数和DI-GM对常规风险因素与卒中关联的可调节作用DOI: 10.20960/nh.06217
Pak J Pharm Sci IF: 00.600Volume 39, Issue 5No.27Role of sodium glucose cotransporter-2 (SGLT2) inhibitors in the modulation of QTc interval and ventricular arrhythmia in patients with diabetes mellitus combined with hypertension and coronary artery disease钠葡萄糖共转运体-2（SGLT2）抑制剂在糖尿病合并高血压和冠心病患者中对QTc间期及室性心律失常的调节作用DOI: 10.36721/PJPS.2026.39.5.REG.15600.1
Current diabetes reviews IF: 01.900Ahead of Print.No.28Mechanisms and Research Progress of SGLT-2 Inhibitors in Diabetes Mellitus-Related Cognitive Impairment钠-葡萄糖协同转运蛋白2抑制剂在糖尿病相关认知障碍中的作用机制及研究进展DOI: 10.2174/0115733998444053260211052025
Pak J Pharm Sci IF: 00.600Volume 39, Issue 5No.29Pharmacological and metabolic effects of Bifidobacterium triple viable capsules and Five-animal Play in patients with impaired glucose tolerance双歧杆菌三联活菌胶囊与五禽戏对糖耐量受损患者的药理和代谢影响DOI: 10.36721/PJPS.2026.39.5.REG.15722.1
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.30Associations of visceral fat accumulation with cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0–3: mediation effects of arterial stiffness in a prospective cohort study心血管-肾脏-代谢综合征0-3期内脏脂肪堆积与心血管疾病的关联：动脉僵硬度的中介作用前瞻性队列研究DOI: 10.1186/s12872-026-05775-z
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.31The effect of dapagliflozin on cardiorespiratory fitness in patients with coronary heart disease and type 2 diabetes mellitus following PCI: a single-center prospective randomized controlled study达格列净对经皮冠状动脉介入治疗后合并冠心病和2型糖尿病患者心肺功能的影响：一项单中心前瞻性随机对照研究DOI: 10.1186/s12872-026-05757-1
ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.32Liposome/Exosome Hybrid Loaded with FGF2 mRNA for Diabetic Wound Healing负载FGF2 mRNA的脂质体/外泌体杂交体用于糖尿病创面愈合DOI: 10.1021/acsami.5c25924
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.33Multidimensional drivers of diabetes prevalence among middle-aged and elderly in China: from a geographical perspective中国中老年糖尿病患病率的多维驱动因素：地理视角DOI: 10.1186/s13098-026-02102-6
BMC medicine IF: 08.300Ahead of Print.No.34Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus糖尿病合并肺结核治疗失败的临床流行病学及风险预测DOI: 10.1186/s12916-026-04803-1
Cell communication and signaling IF: 08.900Ahead of Print.No.35AIBP deficiency drives MAFLD advancement via ITGβ3 mediated lipid metabolism disruption and pro-inflammatory activationAIBP缺失通过ITGβ3介导的脂质代谢紊乱和促炎激活驱动MAFLD进展DOI: 10.1186/s12964-026-02774-7
BMC Med Inform Decis Mak IF: 03.800Ahead of Print.No.36Development and internal validation of a machine learning-based model to predict 1-year all-cause mortality in patients with gastrointestinal bleeding with type 2 diabetes基于机器学习的模型在2型糖尿病合并胃肠道出血患者中预测1年全因死亡率的开发与内部验证DOI: 10.1186/s12911-026-03447-8
BMC nephrology IF: 02.400Ahead of Print.No.37A systematic review and meta-analysis of mesenchymal stem cell therapy in diabetic nephropathy and lupus nephritis or proteinuric nephropathy间充质干细胞治疗在糖尿病肾病、狼疮性肾炎或蛋白尿性肾病中的系统综述与荟萃分析DOI: 10.1186/s12882-026-04859-4
BMC public health IF: 03.600Ahead of Print.No.38Quantifying the interaction between adiposity and hyperglycemia on incident asthma among youth量化青少年中肥胖与高血糖对新发哮喘的相互作用DOI: 10.1186/s12889-026-26967-4
Scientific reports IF: 03.900Ahead of Print.No.39Nonlinear threshold and association of depressive symptoms with pain in middle-aged and older Chinese adults: a cross-sectional and cohort study中国中老年人群抑郁症状与疼痛的非线性阈值及关联：一项横断面和队列研究DOI: 10.1038/s41598-026-44220-1
Obesity surgery IF: 03.100Ahead of Print.No.40Association Between Obstructive Sleep Apnea and Preoperative Cardiopulmonary Fitness in Patients Undergoing Sleeve Gastrectomy: A Real-World Study阻塞性睡眠呼吸暂停与袖状胃切除术前心肺功能的关联：一项真实世界研究DOI: 10.1007/s11695-026-08596-3
npj science of food IF: 07.800Volume 10, Issue 1No.41Author Correction: The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue作者修正：艾草精油通过增强棕色脂肪组织的产热减少高脂饮食诱导的肥胖DOI: 10.1038/s41538-026-00781-z
npj science of food IF: 07.800Ahead of Print.No.42Long-term sucralose exposure accelerates ovarian aging via gut microbiota dysbiosis长期摄入三氯蔗糖通过肠道菌群失调加速卵巢衰老DOI: 10.1038/s41538-026-00775-x
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.43The Impact of Omega-3 Fatty Acids on Triglyceride Levels in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Meta-Analysis of Randomized Controlled Trials with Subgroup Analysis by Diabetes StatusOmega-3多不饱和脂肪酸对非酒精性脂肪性肝病（MASLD）患者甘油三酯水平的影响：一项荟萃分析DOI: 10.2147/DMSO.S573711
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.44Prognostic value of the triglyceride-glucose index for ICU mortality in non-diabetic sepsis: a restricted cubic spline analysis甘油三酯-葡萄糖(TyG)指数作为非糖尿病性脓毒症患者ICU死亡率的预后标志物：一项多中心研究DOI: 10.3389/fendo.2026.1752068
Renal failure IF: 03.000Volume 48, Issue 1No.45Stage-specific utility of obesity indices across the chronic kidney disease continuum分阶段肥胖指数在慢性肾脏病病程中的效用DOI: 10.1080/0886022X.2026.2646000
Plant Physiol Biochem IF: 05.700Volume 232, Issue No.46γ-Aminobutyric acid improves the tolerance of maize to cadmium stress by alleviating oxidative damage and reducing the accumulation and translocation of cadmiumγ-氨基丁酸通过减轻氧化损伤并减少镉的积累和转运来提高玉米对镉胁迫的耐受性DOI: 10.1016/j.plaphy.2026.111068
Diabetes & metabolism journal IF: 08.500Ahead of Print.No.47Influence of Fibroblast Growth Factor 21 on Delayed Glycemic Improvement Following Acute Exercise in Type 2 Diabetes Mellitus成纤维细胞生长因子21对2型糖尿病患者急性运动后延迟血糖改善的影响DOI: 10.4093/dmj.2024.0814
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.48Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations中国人群中氨基酸和微生物群相关代谢物的祖源特异性遗传揭示对心脏代谢疾病的因果影响DOI: 10.1186/s12933-026-03122-2
Burns and trauma IF: 09.600Volume 14, Issue No.49RNA modifications: molecular orchestrators of wound healing伤口愈合的表观转录组调控：N⁶-甲基腺苷（m⁶A）及其以外的作用DOI: 10.1093/burnst/tkag010
Mycology IF: 04.400Volume 17, Issue 1No.50Fungal infections in diabetic foot and other dermatoses: new species and clinical outcomes糖尿病足及其他皮肤病中的真菌感染：新物种与临床结局DOI: 10.1080/21501203.2025.2594944
Frontiers in surgery IF: 01.800Volume 13, Issue No.51Comparison of tibial cortex transverse transport and free anterolateral thigh perforator flap in the treatment of severe diabetic foot ulcers: a retrospective study胫骨皮质横向转运与游离股前外侧穿支皮瓣治疗重度糖尿病足溃疡的比较：一项回顾性研究DOI: 10.3389/fsurg.2026.1742244
Frontiers in public health IF: 03.400Volume 14, Issue No.52The protective role of hearing aids on delayed recall and spatial orientation in age-related hearing loss助听器对年龄相关性听力损失患者延迟回忆和空间定向的保护作用DOI: 10.3389/fpubh.2026.1753247
J Multidiscip Healthc IF: 02.400Volume 19, Issue No.53Health Behavior Protection Motivation and eHealth Literacy in Type 2 Diabetes Patients: A Cross-Sectional Study2型糖尿病患者的健康行为保护动机与电子健康素养：一项横断面研究DOI: 10.2147/JMDH.S576440
Frontiers in aging neuroscience IF: 04.500Volume 18, Issue No.54Brain insulin resistance: a key pathological hub linking metabolic and neuropsychiatric comorbidities脑胰岛素抵抗：衰老中代谢与神经精神共病的关键机制DOI: 10.3389/fnagi.2026.1716291
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.55Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4甘油三酯-葡萄糖指数与4期心血管-肾脏-代谢综合征重症患者的死亡率DOI: 10.1186/s12933-025-03061-4
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.56Dynamic association between triglyceride-glucose-body mass index and hospital mortality in critically ill patients with heart failure: a multicenter retrospective cohort study甘油三酯-血糖-体重指数与重症心力衰竭患者住院死亡率的动态关联：一项多中心回顾性队列研究DOI: 10.1186/s12933-026-03139-7
Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.57Analysis of Biomarkers in Diabetic Foot Ulcer Patients With Dampness-Heat Syndrome Based on 4D-DIA Proteomics Technology基于4D-DIA蛋白质组学技术分析湿热证糖尿病足溃疡患者的生物标志物DOI: 10.1155/jdr/6604989
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.58The association between family history of hypertension and diabetic kidney disease in patients with diabetes: a cross-sectional study2型糖尿病患者中高血压家族史与糖尿病肾病的关联：一项横断面研究DOI: 10.3389/fendo.2026.1774744
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.59Effect of Exercise Based on American College of Sports Medicine Recommendations on Glycemic Management in Patients with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials基于美国运动医学会建议的运动对1型糖尿病患者血糖管理的影响：随机对照试验的系统综述和荟萃分析DOI: 10.2147/DMSO.S568205
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.60Associations Between Gestational Diabetes Mellitus and Neonatal Acyl Metabolic Profiles: An Empirical Study Based on a Birth Cohort妊娠糖尿病与新生儿酰基肉碱谱：一项多中心队列研究DOI: 10.2147/DMSO.S561443
In Vitro Cell Dev Biol Anim IF: 01.700Ahead of Print.No.61Decorin inhibits the migration and invasion of the LPS + high glucose-induced primary trophoblast cell through ADAMTS12核心蛋白聚糖通过ADAMTS12抑制LPS+高糖诱导的原代滋养层细胞迁移和侵袭DOI: 10.1007/s11626-026-01166-y
Frontiers in neurology IF: 02.800Volume 17, Issue No.62Experiences and needs of individuals living with diabetic peripheral neuropathy: a qualitative systematic review and meta-synthesis成年糖尿病周围神经病变患者的生活体验：定性研究的元综合分析DOI: 10.3389/fneur.2026.1746503
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.63Resveratrol and Renal Biomarkers in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials白藜芦醇与2型糖尿病中的肾脏生物标志物：一项更新的随机对照试验系统综述和荟萃分析DOI: 10.2147/DMSO.S402309
Int J Nanomedicine IF: 06.500Volume 21, Issue No.64Nanotechnology-Based Treatment for Ophthalmic Diseases基于纳米技术的眼科疾病治疗DOI: 10.2147/IJN.S597696
Infection and drug resistance IF: 02.900Volume 19, Issue No.65Clinical Characteristics and Glucocorticoids Efficacy in COVID-19 Patients with Type 2 Diabetes: A Multicenter Retrospective Study2型糖尿病合并新型冠状病毒感染患者的临床特征、治疗及长期结局：一项多中心队列研究DOI: 10.2147/IDR.S586849
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.66Eubacterium sp. mediates the anti-obesity effect of lotus leaf extract via brown adipose tissue activation and white fat browning真杆菌属通过棕色脂肪组织激活和白色脂肪褐变介导荷叶提取物的抗肥胖作用DOI: 10.3389/fphar.2026.1727610
Nature and science of sleep IF: 03.400Volume 18, Issue No.67Obstructive Sleep Apnea and Hypercoagulability: Combining Observational and Mendelian Randomization Analyses to Explore Causal Relationships阻塞性睡眠呼吸暂停与高凝状态：结合观察性和孟德尔随机化分析探索因果关系DOI: 10.2147/NSS.S574439
Journal of inflammation research IF: 04.100Volume 19, Issue No.68FGF21 Exacerbates Obesity-Induced Airway Hyperresponsiveness and FGFR1-Dependent Mast Cell Activation in MiceFGF21加重肥胖诱导的气道高反应性及FGFR1依赖性肥大细胞激活DOI: 10.2147/JIR.S570000
Cancer Biology & Medicine IF: 08.400Ahead of Print.No.69Global epidemiology of ovarian cancer: patterns, trends, and risk factors全球卵巢癌流行病学：模式、趋势与风险因素DOI: 10.20892/j.issn.2095-3941.2025.0619
Scand J Med Sci Sports IF: 03.800Volume 36, Issue 4No.70Temporal Variations and Sociodemographic Differences in no Muscle-Strengthening Exercise Among Adolescents: A 10-Year Repeated Cross-Sectional Study青少年中无肌肉强化运动的时间变化及社会人口学差异：一项为期10年的重复横断面研究DOI: 10.1111/sms.70233
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.71Role of combined serum homocysteine and small dense LDL-C in predicting cardiovascular events in obesity: a retrospective clinical study血清同型半胱氨酸与小而密低密度脂蛋白胆固醇联合检测在肥胖人群中心血管事件预测中的作用：一项回顾性临床研究DOI: 10.1186/s12872-026-05771-3
Nature communications IF: 15.700Ahead of Print.No.72Regulation of physical activity and energy expenditure through Phf6 in the medial preoptic area通过内侧视前区的Phf6调控体力活动和能量消耗DOI: 10.1038/s41467-026-70962-7
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.73Propensity score analysis of triglyceride-glucose index in newly diagnosed patients with essential hypertension as a predictor of microalbuminuria甘油三酯-葡萄糖指数在新发原发性高血压患者微量白蛋白尿预测中的作用DOI: 10.3389/fendo.2026.1737230
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.74COVID-19 associated CKM syndrome progression in diabetic patients is linked to pancreatic beta cell dysfunction, rather than RASi use: a retrospective cohort study糖尿病COVID-19患者心血管-肾脏-代谢(CKM)综合征进展：RAS抑制和β细胞功能障碍的作用DOI: 10.3389/fendo.2026.1790281
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.75Efficacy and Safety of Finerenone Combined with Dapagliflozin in the Treatment of Non-Diabetic Chronic Kidney Disease: A Single-Center Retrospective Study非奈利酮联合达格列净治疗非糖尿病慢性肾脏病：一项真实世界回顾性队列研究DOI: 10.2147/DDDT.S564942
Frontiers in immunology IF: 05.900Volume 17, Issue No.76Identification of PANoptosis hub genes driving immune activation and tubulointerstitial injury in diabetic kidney disease by integrative bioinformatics and machine learning通过整合生物信息学和机器学习鉴定驱动糖尿病肾病中免疫激活和肾小管间质损伤的PANoptosis枢纽基因DOI: 10.3389/fimmu.2026.1759781
Frontiers in immunology IF: 05.900Volume 17, Issue No.77Integrated multi-omics analysis unveils microbiota-metabolite-host interactions and novel biomarkers for early diabetic kidney disease diagnosis整合多组学分析揭示微生物群-代谢物-宿主相互作用及早期糖尿病肾病诊断的新型生物标志物DOI: 10.3389/fimmu.2026.1781013
Cell communication and signaling IF: 08.900Ahead of Print.No.78Disulfidptosis induced by intermittent fasting and metformin enhances the efficacy of anti-PD-1 therapy in renal cancer间歇性禁食和二甲双胍诱导的二硫键细胞死亡增强抗PD-1疗法在肾癌中的有效性DOI: 10.1186/s12964-026-02783-6
BMC neurology IF: 02.200Ahead of Print.No.79Metformin-induced encephalopathy in a peritoneal dialysis patient: the critical role of hemodialysis in reversing lentiform fork sign: a case report腹膜透析患者二甲双胍诱导的脑病：血液透析在逆转豆状核分叉征中的关键作用——病例报告DOI: 10.1186/s12883-026-04824-6
Vasc Health Risk Manag IF: 02.800Volume 22, Issue No.80Utility of Novel Lipid Parameters for Risk Stratification in Patients with Diabetes and STEMI-from a Prospective Study新型脂质参数在糖尿病和STEMI患者风险分层中的应用——一项前瞻性研究DOI: 10.2147/VHRM.S560787
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.81The Potential Role of SGLT2 Inhibitors in the Treatment of Depression: Mechanisms and Clinical Prospects钠-葡萄糖协同转运蛋白2抑制剂在抑郁症治疗中的潜在作用：机制与临床前景DOI: 10.2147/DDDT.S567851
Frontiers in nutrition IF: 05.100Volume 13, Issue No.82The triglyceride-glucose index in chronic kidney disease: a narrative review甘油三酯-葡萄糖指数在慢性肾脏病中的综合综述DOI: 10.3389/fnut.2026.1758394
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.83Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications甘油三酯-葡萄糖指数及其衍生物作为胰岛素抵抗的新兴生物标志物用于心血管-肾脏-代谢综合征的预后评估：机制与临床应用DOI: 10.3389/fphar.2026.1787130
Clin Cosmet Investig Dermatol IF: 02.200Volume 19, Issue No.84Social Determinants of Health as a Predictor of Psoriasis Risk: Preliminary Findings from a National Survey社会决定因素健康与银屑病风险：美国全国性研究DOI: 10.2147/CCID.S572283
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Metabolism IF: 11.900Ahead of Print.No.24Metabolomics profiles of type 2 diabetes and insulin resistance and their associations with total mortality. T2D metabolites linked to mortality2型糖尿病和胰岛素抵抗的代谢组学特征及其与总死亡率的关联。T2D代谢物与死亡率相关DOI: 10.1016/j.metabol.2026.156599
Endocrine practice IF: 04.600Ahead of Print.No.25Effects of an Electronic Health Record Choice Architecture Intervention on Inpatient HbA1c Testing Rates and Patient Outcomes电子健康记录选择架构干预对住院患者糖化血红蛋白检测率及患者结局的影响DOI: 10.1016/j.eprac.2026.03.006
J Plast Reconstr Aesthet Surg IF: 02.400Ahead of Print.No.26GLP-1 receptor agonist use and surgical outcomes following diabetic foot reconstruction: A propensity score-matched retrospective cohort studyGLP-1受体激动剂使用与糖尿病足重建术后手术结局：一项倾向得分匹配的回顾性队列研究DOI: 10.1016/j.bjps.2026.03.001
International wound journal IF: 02.500Volume 23, Issue 4No.27Diabetes-Related Foot Ulcers: The Role of Informal Caregivers' Experiences and Needs Regarding Involvement in Multidisciplinary Team Treatment. A Qualitative Study糖尿病相关足部溃疡：非正规护理人员参与多学科团队治疗的经验与需求——一项定性研究DOI: 10.1111/iwj.70891
Clinical nutrition IF: 07.400Ahead of Print.No.28Targeting weight loss and blood glucose control with oral sodium butyrate in overweight/obese adults with and without type 2 diabetes: A proof-of-concept randomized controlled trial口服丁酸钠在超重/肥胖成年人群（含/不含2型糖尿病）中针对体重减轻与血糖控制的概念验证随机对照试验DOI: 10.1016/j.clnu.2026.106624
BMJ open IF: 02.300Volume 16, Issue 3No.29Prevalence and predictors of diabetes distress in Volta Region, Ghana: a health facility-based cross-sectional study加纳沃尔特地区糖尿病困扰的患病率及预测因素：一项基于医疗机构的横断面研究DOI: 10.1136/bmjopen-2025-110791
Endocrine practice IF: 04.600Ahead of Print.No.30High incidence of gestational diabetes mellitus in females with CF persists in the triple CFTR modulator era: implications for screening囊性纤维化女性在三重CFTR调节剂时代妊娠糖尿病高发病率持续存在：对筛查的启示DOI: 10.1016/j.eprac.2026.02.018
Journal of orthopaedic surgery IF: 01.600Volume 34, Issue 1No.31The phantom paradox: Protective and risk factors for phantom limb pain following major lower extremity amputation幻肢悖论：重大下肢截肢术后幻肢痛的保护因素与风险因素DOI: 10.1177/10225536261439416
Endocrine practice IF: 04.600Ahead of Print.No.32Cardiometabolic Risk in Bilateral vs Unilateral Nonfunctioning Adrenal Incidentalomas: Evidence From a Large Referral Center Cohort心脏代谢风险在双侧与单侧无功能性肾上腺偶发瘤中的比较：来自大型转诊中心队列的证据DOI: 10.1016/j.eprac.2026.03.005
Exp Clin Endocrinol Diabetes IF: 01.700Volume 134, Issue 3No.33Assessment of subclinical myocardial dysfunction and osteogenic biomarkers in normoglycemic individuals with familial predisposition to type 2 diabetes mellitus2型糖尿病家族易感性正常血糖个体的亚临床心肌功能障碍及成骨生物标志物评估DOI: 10.1055/a-2790-9134
Health & place IF: 04.100Ahead of Print.No.34Understanding rural food environments and malnutrition-related mortality disparities: A typological approach from Mexico理解墨西哥农村食物环境及与营养不良相关的死亡率差异：一种类型学方法DOI: 10.1016/j.healthplace.2026.103652
Exp Clin Endocrinol Diabetes IF: 01.700Volume 134, Issue 3No.35GLP-1 receptor agonists or SGLT2-inhibitors? Evaluation of a personalized treatment algorithm for individuals with type 2 diabetes: a registry-based cohort studyGLP-1受体激动剂或SGLT2抑制剂？评估针对2型糖尿病患者的个性化治疗算法：一项基于登记的队列研究DOI: 10.1055/a-2798-6496
BMJ case reports IF: 00.500Volume 19, Issue 3No.36Cerebral venous thrombosis in pregnancy妊娠期脑静脉血栓形成DOI: 10.1136/bcr-2025-265688
Life sciences IF: 05.100Ahead of Print.No.37Ameliorative effect of Rhus verniciflua Stokes on high-fat diet-induced obesity and advanced analysis with machine learning and deep learning-based network pharmacology漆树（Rhus verniciflua Stokes）对高脂饮食诱导的肥胖的改善作用及结合机器学习和深度学习的网络药理学高级分析DOI: 10.1016/j.lfs.2026.124337
Exp Clin Endocrinol Diabetes IF: 01.700Volume 134, Issue 3No.38Pilot study: transduction of primary paraganglioma chromaffin tumour cells with inducible c-MYC drives cell proliferation初步研究：诱导型c-MYC转导原发性副神经节瘤嗜铬细胞瘤细胞驱动细胞增殖DOI: 10.1055/a-2797-3576
European Heart Journal IF: 35.600Ahead of Print.No.39Sex differences in cardiovascular–kidney–metabolic syndrome: the FINE-HEART pooled analysis心血管-肾脏-代谢综合征中的性别差异：FINE-HEART汇总分析DOI: 10.1093/eurheartj/ehag162
JMIR IF: 06.000Volume 28, Issue No.40Determinants of the Uptake and Frequency of Use of a Web Portal Digital Health Intervention in Patients With Type 2 Diabetes and/or Coronary Heart Disease: Secondary Analysis of a Randomized Controlled Trial2型糖尿病和/或冠心病患者中网络门户数字健康干预的采用及使用频率决定因素：一项随机对照试验的二次分析DOI: 10.2196/80895
J Patient Rep Outcomes IF: 02.900Ahead of Print.No.41Development of the Patient Satisfaction with Medication for Diabetes (PSMD) questionnaire糖尿病用药患者满意度（PSMD）问卷的开发DOI: 10.1186/s41687-026-01037-w
Osteoporosis international IF: 05.400Ahead of Print.No.42DXA in post-fracture care: gatekeeper or facilitator?骨折后护理中的双能X线骨密度仪（DXA）：守门人还是推动者？DOI: 10.1007/s00198-026-07976-w
GeroScience IF: 05.400Ahead of Print.No.43Distinct effects of aging and klotho deletion on the choroid plexus衰老和Klotho缺失对脉络丛的不同影响DOI: 10.1007/s11357-026-02196-w
Odontology IF: 02.400Ahead of Print.No.44The spiral of reintervention: clinical outcomes of successive restorative treatments in permanent teeth再干预的螺旋：恒牙连续修复治疗的临床结局DOI: 10.1007/s10266-026-01351-1
J Endocrinol Invest IF: 03.500Ahead of Print.No.45The paracrine signalling between endothelial and pancreatic β-cells: implications for oxidative stress and diabetes内皮细胞与胰岛β细胞之间的旁分泌信号：对氧化应激和糖尿病的影响DOI: 10.1007/s40618-026-02869-5
J Endocrinol Invest IF: 03.500Ahead of Print.No.46Mutational patterns in a large cohort of parathyroid carcinomas甲状旁腺癌大样本队列中的突变模式DOI: 10.1007/s40618-026-02855-x
NEJM IF: 78.500Volume 394, Issue 12No.47Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis替尔泊肽用于代谢功能障碍相关的脂肪性肝炎伴肝纤维化DOI: 10.1056/NEJMx250014
PloS one IF: 02.600Volume 21, Issue 3No.48Prevalence and risk factors of disordered eating risk among Yemeni medical students: A national multicenter cross-sectional study也门医学生进食障碍风险的患病率及危险因素：一项全国多中心横断面研究DOI: 10.1371/journal.pone.0345771
European journal of epidemiology IF: 05.900Ahead of Print.No.49Vegetarian and vegan diets and cancer incidence: a systematic review and meta-analysis of prospective studies素食和纯素饮食与癌症发病率：前瞻性研究的系统综述与荟萃分析DOI: 10.1007/s10654-026-01380-8
Bull Exp Biol Med IF: 00.600Volume 180, Issue 2No.50Relationship between Myocardial Adaptive Resistance to Ischemia/Reperfusion and Leptin Receptor Expression in Rats with Metabolic Syndrome代谢综合征大鼠心肌缺血/再灌注适应抵抗与瘦素受体表达的关系DOI: 10.1007/s10517-026-06605-0
Brain and behavior IF: 02.700Volume 16, Issue 4No.51Efficacy and Safety of Glucagon-Like Peptide 1 Receptor Agonists in Parkinson Disease: A Systematic Review and Meta-Analysis胰高血糖素样肽-1受体激动剂在帕金森病中的有效性和安全性：一项系统综述与荟萃分析DOI: 10.1002/brb3.71344
PloS one IF: 02.600Volume 21, Issue 3No.52Genetic variants associated with systemic inflammatory disease associate with temporomandibular symptoms with or without periodontitis与系统性炎症疾病相关的遗传变异与颞下颌症状（伴或不伴牙周炎）相关DOI: 10.1371/journal.pone.0328855
PloS one IF: 02.600Volume 21, Issue 3No.53Compassion-focused group therapy improves depression, emotional eating, self-criticism and shame in people living with severe obesity: A single-centre, examiner-blind randomized controlled trial专注于共情的团体治疗改善重度肥胖患者的抑郁、情绪性进食、自我批评和羞耻感：一项单中心、考官设盲的随机对照试验DOI: 10.1371/journal.pone.0342744
J Exp Med IF: 10.600Volume 223, Issue 5No.54MYCT1-IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansionMYCT1-IFITM2/3相互作用将内皮内体溶酶体运输与白色脂肪组织扩张联系起来DOI: 10.1084/jem.20251497
Appl Health Econ Health Policy IF: 03.300Ahead of Print.No.55A Systematic Review of Microsimulation Models in Cardiometabolic Disease: Model Calibration and Validation心脏代谢性疾病微模拟模型的系统综述：模型校准与验证DOI: 10.1007/s40258-026-01036-4
Current HIV/AIDS reports IF: 04.400Volume 23, Issue 1No.56To Switch or not to Switch: are there any Antiretroviral Strategies to Attenuate Weight Gain in People with HIV?换还是不换：是否有抗逆转录病毒策略可减轻HIV感染者的体重增加DOI: 10.1007/s11904-026-00782-3
Obesity surgery IF: 03.100Ahead of Print.No.57New-onset Anorectal Symptoms and Disorders After Bariatric Surgery: An Overlooked Entity减重手术后新发肛肠症状及疾病：一个被忽视的实体DOI: 10.1007/s11695-026-08614-4
JMIR diabetes IF: 02.600Volume 11, Issue No.58A Quantitative Framework for Evaluating the Performance of Algorithm-Directed Whole-Population Remote Patient Monitoring: Tutorial for Type 1 Diabetes Care算法指导的全人群远程患者监测性能评估的定量框架：1型糖尿病护理教程DOI: 10.2196/72676
Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 13No.59Immune cell profiling reveals expanded stem cell-like memory T cells in anti-GAD65-associated neurological syndromes免疫细胞分析揭示抗GAD65相关神经综合征中扩增的干细胞样记忆T细胞DOI: 10.1073/pnas.2514753123
Science advances IF: 12.500Volume 12, Issue 13No.60Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages小麦纤维通过非SCFA微生物代谢物训练的肠道巨噬细胞缓解结肠炎DOI: 10.1126/sciadv.aec5757
ABC Cardiol IF: 01.900Volume 123, Issue 2No.61Operative Experience and Clinical Outcomes in Cardiac Myxoma Patients: A Retrospective Single-Center Study心脏黏液瘤患者的手术经验与临床结局：一项回顾性单中心研究DOI: 10.36660/abc.20250596
PloS one IF: 02.600Volume 21, Issue 3No.62Predictors of employment attrition in Lebanon during multifaceted crises: The role of chronic diseases - a national cross-sectional study黎巴嫩多方面危机期间就业流失的预测因素：慢性病的作用——一项全国性横断面研究DOI: 10.1371/journal.pone.0328028
JMIR diabetes IF: 02.600Volume 11, Issue No.63Exploring the Integration of Consumer Activity Trackers Into a Community Weight Management Intervention to Support Physical Activity in Adults at Risk for or With Type 2 Diabetes: Mixed Methods Study Using the RE-AIM Framework探索将消费者活动追踪器整合到社区体重管理干预中以支持患有或有患2型糖尿病风险的成年人的体力活动：采用RE-AIM框架的混合方法研究DOI: 10.2196/91073
Panminerva Medica IF: 04.300Ahead of Print.No.64Characteristics and outcomes of spontaneous coronary artery dissection versus Takotsubo Syndrome: a systematic review and meta-analysis自发性冠状动脉夹层与Takotsubo综合征的特征及结局：一项系统综述与荟萃分析DOI: 10.23736/S0031-0808.26.05415-7
Molecular biology reports IF: 02.800Volume 53, Issue 1No.65The myofibrillar myopathy-linked variant DES-p.T341P impairs desmin filament assembly肌原纤维性肌病相关的DES-p.T341P变异损害结蛋白丝组装DOI: 10.1007/s11033-026-11696-z
Drugs IF: 14.400Ahead of Print.No.66Efficacy and Safety of Anti-nerve Growth Factor Monoclonal Antibodies in Managing Chronic Musculoskeletal Pain: A Systematic Review with Network Meta-analysis抗神经生长因子单克隆抗体在慢性肌肉骨骼疼痛管理中的有效性与安全性：一项系统综述与网状Meta分析DOI: 10.1007/s40265-026-02304-2
Molecular biology reports IF: 02.800Volume 53, Issue 1No.67Mitochondrial miRNA- miR-181c-5p and mitomiR-106a-5p levels as indicators in cardiovascular disease patients线粒体微小RNA miR-181c-5p和mitomiR-106a-5p水平作为心血管疾病患者的指标DOI: 10.1007/s11033-026-11617-0
Int J Health Econ Manag IF: 01.700Volume 26, Issue 2No.68Association between patient continuity of care and physicians' hypoglycaemic medication prescription trends患者连续性护理与医师降糖药物处方趋势的关联DOI: 10.1007/s10754-026-09410-4
Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.69Unnatural amino acid compounds as potent multi-target inhibitors of aldose reductase, α-glucosidase, and α-amylase: integrated in vitro, SAR, and molecular dynamics insights非天然氨基酸化合物作为醛糖还原酶、α-葡萄糖苷酶和α-淀粉酶的强效多靶点抑制剂：整合体外实验、构效关系及分子动力学研究见解DOI: 10.1007/s00210-026-05249-1
Brazilian Journal of BiologyVolume 85, Issue No.70Potent antioxidant and anticancer efficacy of Brassica oleracea var acephala extracts: a cytomorphological and antidiabetic assessment甘蓝Acephala变种提取物的强抗氧化和抗癌有效性：一项细胞形态学和抗糖尿病评估DOI: 10.1590/1519-6984.291259
An Acad Bras Cienc IF: 01.100Volume 98, Issue 1No.71Optimization of the extraction of Curcuma longa L. oleoresin with supercritical CO2超临界CO2萃取姜黄油树脂的工艺优化DOI: 10.1590/0001-3765202620250147
NEJM IF: 78.500Volume 394, Issue 12No.72Clinical Implications of Minipuberty小青春期的临床意义DOI: 10.1056/NEJMra2305989
Science translational medicine IF: 14.600Volume 18, Issue 842No.73Beyond bystanders: How β cell stress shapes the autoimmune response in T1D超越旁观者：β细胞应激如何影响1型糖尿病中的自身免疫反应DOI: 10.1126/scitranslmed.aed3762
Science translational medicine IF: 14.600Volume 18, Issue 842No.74NKX6.1 mRNA copy number is an actionable biomarker associated with islet function and clinical outcomes after islet transplantationNKX6.1 mRNA拷贝数是与胰岛功能及胰岛移植后临床结局相关的可干预生物标志物DOI: 10.1126/scitranslmed.aed3562
Journal of general virology IF: 04.300Volume 107, Issue 3No.75Bovine respiratory syncytial virus utilizes the human insulin-like growth factor 1 receptor in the late stages of infection牛呼吸道合胞病毒在感染后期利用人胰岛素样生长因子1受体DOI: 10.1099/jgv.0.002241
J Sports Med Phys Fitness IF: 01.300Ahead of Print.No.76A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review兴奋剂的新时代？肽类及肽类似物药物在休闲与职业体育及健美运动中的使用：批判性综述DOI: 10.23736/S0022-4707.26.17773-1
Diabetes therapy IF: 02.600Ahead of Print.No.77Ten-Year Trends in Healthcare Use and Costs for People Living with Diabetes in France: Results from the Epicodiab Study Based on National Claims Data法国糖尿病患者医疗使用与费用十年趋势：基于国家理赔数据的Epicodiab研究结果DOI: 10.1007/s13300-026-01850-y
JMIR research protocols IF: 01.500Volume 15, Issue No.78Exploring the Impact of Initiating Endocrine Therapy on Metabolic Health in Early Breast Cancer: Protocol for the Prospective Follow-Up EMETA-Study探索启动内分泌治疗对早期乳腺癌代谢健康的影响：前瞻性随访EMETA研究方案DOI: 10.2196/78589
Current nutrition reports IF: 05.500Volume 15, Issue 1No.79Hypomagnesemia: A Clinical and Nutritional Update低镁血症：综合综述DOI: 10.1007/s13668-026-00745-5
Clinical nephrology IF: 01.000Ahead of Print.No.80Adult male Fournier gangrene hospitalizations with and without end-stage kidney disease: A 5-year nationwide analysis成年男性Fournier坏疽住院病例（有无终末期肾病）：一项为期5年的全国性分析DOI: 10.5414/CN111912
Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 3No.81Choriocapillaris Flow Signal Deficits Are Associated With AMD Onset and Early Progression Over Three Years: ALSTAR2 Follow-Up脉络膜毛细血管血流信号缺失与AMD的发生及三年内的早期进展相关：ALSTAR2随访研究DOI: 10.1167/iovs.67.3.51
Nutrición hospitalaria IF: 01.100Ahead of Print.No.82Unfavorable lifestyle, hypertriglyceridemia and smoking are risk factors for chronic kidney disease in people with type 2 diabetes不良生活方式、高甘油三酯血症和吸烟是2型糖尿病患者慢性肾脏病的危险因素DOI: 10.20960/nh.06423
Minerva endocrinology IF: 01.900Ahead of Print.No.83Real-time continuous glucose monitoring with subcutaneously inserted sensor correlates better than subcutaneously implantable sensor with glycated hemoglobin, glycated albumin and fructosamine皮下插入式传感器的实时连续血糖监测与皮下植入式传感器相比，与糖化血红蛋白、糖化白蛋白和果糖胺的相关性更好DOI: 10.23736/S2724-6507.26.04486-6
J Diabetes Investig IF: 03.000Ahead of Print.No.84Diabetic foot ulcer-related amputation is associated with twofold increased risk of cardiovascular disease: A Korean National Health Information Database Study糖尿病足溃疡相关截肢与心血管疾病风险增加两倍相关：一项韩国国家健康信息数据库研究DOI: 10.1111/jdi.70268
JAMA surgery IF: 14.900Ahead of Print.No.85Veterans Hospitals vs Non-Veterans Centers in the Prevention of Limb Loss退伍军人医院与非退伍军人中心在肢体丢失预防方面的比较DOI: 10.1001/jamasurg.2026.0489
Drug Dev Ind Pharm IF: 02.200Ahead of Print.No.86Development of berberine-loaded PEGylated liposomes: in-vitro and ex-vivo evaluation小檗碱负载聚乙二醇化脂质体的开发：体外和离体评价DOI: 10.1080/03639045.2026.2642083
J Perianesth Nurs IF: 02.000Ahead of Print.No.87Perioperative Glucose Control in Vascular Patients via Implementation of a Standard Perioperative Glucose Protocol通过实施标准化围手术期血糖协议改善血管患者围手术期血糖控制DOI: 10.1016/j.jopan.2026.02.002
Aust N Z J Obstet Gynaecol IF: 01.700Volume 66, Issue 2No.88Healthcare for People With Diabetes in Pregnancy: A National Survey Comparing Metropolitan and Rural Care Delivery in Australia妊娠期糖尿病患者的医疗保健：澳大利亚一项比较都会区和农村地区医疗服务提供情况的全国性调查DOI: 10.1111/ajo.70109
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 3No.89State of the Art and Future Perspectives of Continuous Glucose Monitoring in Intensive and Non-Intensive Care Settings重症和非重症监护环境下持续葡萄糖监测的最新进展与未来展望DOI: 10.1002/dmrr.70154
Clinical endocrinology IF: 02.400Ahead of Print.No.90Immune Checkpoint Inhibitor Therapy Induced Hypophysitis; A Tertiary Care Centre Experience; Highlighting Detection, Treatment Outcomes and Long Term Endocrinopathies and Recovery免疫检查点抑制剂治疗诱导的垂体炎：一家三级医疗中心的经验，重点突出检测、治疗结果及长期内分泌疾病和恢复DOI: 10.1111/cen.70137
AIDS IF: 03.100Ahead of Print.No.91Changes in weight and glycemia after initiation of integrase strand transfer inhibitors among people with HIV and diabetes in the United States and Canada美国和加拿大HIV合并糖尿病患者开始使用整合酶链转移抑制剂后的体重和血糖变化DOI: 10.1097/QAD.0000000000004502
Arthritis & rheumatology IF: 10.900Ahead of Print.No.92Per- and polyfluoroalkyl substances and knee osteoarthritis: data from the Osteoarthritis Initiative全氟和多氟烷基物质与膝关节骨关节炎：来自骨关节炎倡议的数据DOI: 10.1002/art.70154
Physiological reports IF: 01.900Volume 14, Issue 6No.93A comparison of resting metabolic rate measurement in adults, using a ventilated canopy or a mixing-chamber system with a silicone mask成年人静息代谢率测量方法比较：通风罩系统 vs 带硅胶面罩的混合室系统DOI: 10.14814/phy2.70837
Advanced science IF: 14.100Ahead of Print.No.94Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes骨类器官：糖尿病骨骼疾病建模与管理的新型工具DOI: 10.1002/advs.202518788
Int J Clin Pharmacol Ther IF: 00.900Ahead of Print.No.95Peripheral nerve regeneration and synergistic pharmacology using Hericium erinaceus, lithium, and vitamin B12: The triple neuromodulatory axis hypothesis使用猴头菇、锂和维生素B12的周围神经再生及协同药理学：三重神经调节轴假说DOI: 10.5414/CP204956
Nutrición hospitalaria IF: 01.100Ahead of Print.No.96Interpretable machine learning models predict cognitive impairment in adults aged 50 and over with diabetes: influence of dietary nutrients可解释机器学习模型预测50岁及以上糖尿病成人认知障碍：饮食营养素的影响DOI: 10.20960/nh.06195
JAMA Cardiology IF: 14.100Ahead of Print.No.97Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial左心耳封堵术后大出血的发生率、预测因素、处理及临床影响：Amulet IDE随机临床试验DOI: 10.1001/jamacardio.2026.0336
European Heart Journal IF: 35.600Ahead of Print.No.98Weekly Journal Scan: Tirzepatide did not SURPASS the cardiovascular benefits of dulaglutide in type 2 diabetes周期刊扫描：替尔泊肽在2型糖尿病中的心血管获益未超过度拉糖肽DOI: 10.1093/eurheartj/ehag194
J Chem Inf Model IF: 05.300Ahead of Print.No.99Unveiling the Activation Mechanism of Glucagon-Like Peptide-1 Receptor by an Ago-Allosteric Modulator via Molecular Dynamics Simulations通过分子动力学模拟揭示Ago变构调节剂对胰高血糖素样肽-1受体的激活机制DOI: 10.1021/acs.jcim.6c00224
J Hepatobiliary Pancreat Sci IF: 02.800Ahead of Print.No.100Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta-Analysis胰十二指肠切除术后脂肪性肝病的发病率及影响因素：一项系统综述与荟萃分析DOI: 10.1002/jhbp.70107
Nutrición hospitalaria IF: 01.100Ahead of Print.No.101Changes in physical growth and nutritional status in adolescents in a region of Chile智利某地区青少年身体发育和营养状况的变化DOI: 10.20960/nh.06104
Oral Health Prev Dent IF: 01.400Volume 24, Issue No.102Associations Between Comorbidities, Medication Use and Dental Outcomes in Clinical Practice in Hail Dental Centre in Saudi Arabia: A Retrospective Study沙特阿拉伯海伊勒牙科中心临床实践中共病、药物使用与牙科结局的关联：一项回顾性研究DOI: 10.3290/j.ohpd.c_2615
Microbiology spectrum IF: 03.800Ahead of Print.No.103Metagenomic profiling and predictive modeling of the gut microbiome reveal signatures of gestational disease肠道微生物组的宏基因组分析和预测模型揭示妊娠疾病特征DOI: 10.1128/spectrum.03155-25
Nutrición hospitalaria IF: 01.100Ahead of Print.No.104Insulin Resistance Metabolic Score as a predictor of gestational diabetes mellitus: evidence from NHANES 1999-2016胰岛素抵抗代谢评分作为妊娠糖尿病的预测指标：来自1999-2016年NHANES的数据DOI: 10.20960/nh.06183
Nutrición hospitalaria IF: 01.100Ahead of Print.No.105Glycosylated hemoglobin mediates the association between insulin-resistance and incident cataract risk: insights from the NHANES 1999-2008糖化血红蛋白介导胰岛素抵抗与白内障发病风险的关联：来自NHANES 1999-2008的研究见解DOI: 10.20960/nh.06022
J Investig Med High Impact Case Rep IF: 00.900Volume 14, Issue No.106"First Reported Case of Rapidly Progressive Pyogenic Liver Abscess with Isolation of Priestia megaterium: Case Report and Literature Review"首次报道的分离出Priestia megaterium的快速进展性化脓性肝脓肿病例报告及文献综述DOI: 10.1177/23247096261436690
JACC IF: 22.300Ahead of Print.No.107Redefining Primary Aldosteronism重新定义原发性醛固酮增多症DOI: 10.1016/j.jacc.2026.02.5090
Clinical nephrology IF: 01.000Ahead of Print.No.108Development of prediction models for cardiovascular disease mortality risk in maintenance hemodialysis patients based on nomogram and CART algorithm基于列线图和CART算法的维持性血液透析患者心血管疾病死亡风险预测模型的开发DOI: 10.5414/CN111819
Folia medicaVolume 68, Issue 1No.109Hyperbaric oxygen therapy of diabetic foot ulcers: a pilot study糖尿病足溃疡的高压氧疗法：一项试点研究DOI: 10.3897/folmed.68.e166916
Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.110Immunomodulatory Tissue-Engineering Strategies for Diabetic Foot Ulcer Management: A Systematic Review免疫调节组织工程策略用于糖尿病足溃疡管理：系统综述DOI: 10.1111/wrr.70149
La Revue du praticienVolume 76, Issue 3No.111[Sinonasal and petrous bone fungal infections]鼻-鼻窦和岩骨真菌感染https://pubmed.ncbi.nlm.nih.gov/41878959
European Heart Journal IF: 35.600Ahead of Print.No.112Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets心房颤动中的炎症通路：机制与新型治疗靶点DOI: 10.1093/eurheartj/ehag131
Leukemia and lymphoma IF: 02.200Ahead of Print.No.113Metabolic dysfunction-associated steatotic liver disease and acute leukemias - a literature review and future directions代谢功能障碍相关脂肪性肝病与急性白血病——文献综述及未来方向DOI: 10.1080/10428194.2026.2640454
Annals of Vascular Surgery IF: 01.600Ahead of Print.No.114GLP-1 receptor agonist use is associated with venous ulcer healing and fewer wound infections胰高血糖素样肽-1受体激动剂使用与静脉性溃疡愈合及更少的伤口感染相关DOI: 10.1016/j.avsg.2026.03.023
Pak J Pharm Sci IF: 00.600Volume 39, Issue 5No.115Allicin based inhibition of eryptosis: A novel therapeutic approach against hyperosmolarity triggered anemia基于大蒜素的红细胞自杀性死亡抑制：一种针对高渗诱发贫血的新型治疗方法DOI: 10.36721/PJPS.2026.39.5.REG.15510.1
Current diabetes reviews IF: 01.900Ahead of Print.No.116Beyond Glycemic Control: Biographical Disruption and the Lived Experience of Youth with Type 1 Diabetes超越血糖控制：1型糖尿病青少年的传记性中断与生活体验DOI: 10.2174/0115733998458230260223083418
Ginekologia Polska IF: 01.000Ahead of Print.No.117Revisiting maternal adiposity - subcutaneous fat thickness as a robust predictor of insulin requirement in gestational diabetes mellitus重新审视母体肥胖——皮下脂肪厚度作为妊娠糖尿病中胰岛素需求量的可靠预测因子DOI: 10.5603/gpl.107816
Journal of medicinal food IF: 02.000Ahead of Print.No.118Heat-Treated Culture-Dried Lactiplantibacillus plantarum L-14 Regulates Lipid Metabolism and Attenuates Diet-Induced Obesity in Adipose Tissue热处理培养干燥的植物乳杆菌L-14调节脂质代谢并减轻饮食诱导的脂肪组织肥胖DOI: 10.1177/1096620X261434662
British journal of nutrition IF: 03.000Ahead of Print.No.119Food-based healthy diet metrics, type 2 diabetes, and insulin resistance in ELSA-Brasil: a prospective study of over 12,000 Brazilians以食物为基础的健康饮食指标、2型糖尿病及胰岛素抵抗在巴西成人健康纵向研究（ELSA-Brasil）中：对超过12,000名巴西人的前瞻性研究DOI: 10.1017/S0007114526106886
Nutrición hospitalaria IF: 01.100Ahead of Print.No.120[Effect of different doses of vitamin D on body composition and cardiometabolic factors in adolescents with obesity]不同剂量维生素D对肥胖青少年身体成分和心脏代谢因素的影响DOI: 10.20960/nh.06115
Nutrición hospitalaria IF: 01.100Ahead of Print.No.121Correlations of asprosin and cyclophilin A levels with intestinal flora plus pregnancy outcome in patients with gestational diabetes mellitus妊娠糖尿病患者中Asprosin和亲环素A水平与肠道菌群及妊娠结局的相关性DOI: 10.20960/nh.06080
Cardiovasc Hematol Disord Drug TargetsAhead of Print.No.122A Double Whammy of Takotsubo Cardiomyopathy and Severe Hypernatremia in a Patient with Recurrent Craniopharyngioma: A Case Report and Literature Review复发性颅咽管瘤患者同时发生Takotsubo心肌病和严重高钠血症：一例报告及文献复习DOI: 10.2174/011871529X433408260112074812
Pak J Pharm Sci IF: 00.600Volume 39, Issue 5No.123Synthesis, characterization, blood biochemical parameters evaluation and antidiabetic potential of thiobarbiturate derivatives硫代巴比妥酸衍生物的合成、表征、血液生化参数评估及抗糖尿病潜力DOI: 10.36721/PJPS.2026.39.5.REG.15213.1
Pak J Pharm Sci IF: 00.600Volume 39, Issue 5No.124Exploring pulegone in type 2 diabetes treatment: Molecular docking, influence on insulin resistance and modulation of pro/anti-inflammatory cytokines探索薄荷酮在2型糖尿病治疗中的作用：分子对接、对胰岛素抵抗的影响及对促/抗炎细胞因子的调节DOI: 10.36721/PJPS.2026.39.5.REG.14867.1
Aust N Z J Obstet Gynaecol IF: 01.700Volume 66, Issue 2No.125Birth Parameters, Neonatal and Obstetric Outcomes of Mothers With Gestational Diabetes Treated With Diet and Insulin: A Retrospective Study妊娠糖尿病母亲经饮食和胰岛素治疗后的出生参数、新生儿及产科结局：一项回顾性研究DOI: 10.1111/ajo.70114
Clin Obstet Gynecol IF: 01.400Ahead of Print.No.126Type 2 Diabetes in Pregnancy: Management and Novel Therapies妊娠2型糖尿病：管理及新型疗法DOI: 10.1097/GRF.0000000000001008
Mini Rev Med Chem IF: 03.300Ahead of Print.No.127Antidiabetic Activity of Sulfonamide Derivatives磺胺衍生物的抗糖尿病活性DOI: 10.2174/0113895575436530260108071913
Current drug metabolism IF: 01.800Ahead of Print.No.128Development and Evaluation of a Baicalin-Loaded Phytosomal Transdermal Patch for Type 2 Diabetes Mellitus黄芩素负载植物脂质体透皮贴剂用于2型糖尿病的开发与评价DOI: 10.2174/0113892002437368260113092840
AIDS IF: 03.100Ahead of Print.No.129Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for Hepatitis C virus in people with HIVHIV感染者接受丙型肝炎直接作用抗病毒药物治疗后2型糖尿病的风险DOI: 10.1097/QAD.0000000000004499
Current Cardiology Reports IF: 03.300Volume 28, Issue 1No.130GLP-1 Receptor Agonists and Cardiovascular and Kidney Outcomes by Body Mass Index in Type 2 Diabetes胰高血糖素样肽-1受体激动剂在2型糖尿病中按体重指数的心血管和肾脏结局DOI: 10.1007/s11886-026-02356-6
Curr. Treat. Options Cardiovasc. IF: 00.600Volume 28, Issue 1, Page 1- 2No.131Obesity Management and Cardiovascular Risk Reduction: from Tradition to Innovation肥胖管理与心血管风险降低：从传统到创新DOI: 10.1007/s11936-026-01138-1
Frontiers in medicine IF: 03.000Volume 13, Issue No.132Hybrid GAN-LSTM framework for diabetic foot ulcer image synthesis and automated diagnosis结合LSTM的混合生成对抗网络用于糖尿病足溃疡图像生成与分类DOI: 10.3389/fmed.2026.1742345
VASA IF: 02.400Ahead of Print.No.133Patient participation in supervised exercise therapy and its impact on outcomes and quality of life in peripheral arterial disease患者参与监督运动疗法及其对外周动脉疾病中结局和生活质量的影响DOI: 10.1024/0301-1526/a001280
Cell transplantation IF: 03.200Volume 35, Issue No.134Human islet isolation optimization: Insights from donor and isolation procedural factors人胰岛分离优化：来自供体和分离操作因素的见解DOI: 10.1177/09636897261433325
BMC public health IF: 03.600Ahead of Print.No.135Women's empowerment and health: nationwide insights on selected non-communicable conditions in Bangladesh女性赋权与健康：孟加拉国特定非传染性疾病的全国性见解DOI: 10.1186/s12889-026-27084-y
BMC public health IF: 03.600Ahead of Print.No.136The intersection of place and health: examining the association of social determinants of health and diabetes in children and adolescents in Florida地方与健康的交集：研究佛罗里达州儿童和青少年健康的社会决定因素与糖尿病的关联DOI: 10.1186/s12889-026-27119-4
Aust J Rural Health IF: 02.100Volume 34, Issue 2No.137Tobacco Smoking-Attributable Burden of Disease in the Adult Northern Territory Population, 2014-182014-2018年北领地成年人群中烟草吸烟导致的疾病负担DOI: 10.1111/ajr.70155
EMBO reports IF: 06.200Ahead of Print.No.138Cystinosin regulates Na(+)/H(+) exchanger 3 trafficking and function in kidney proximal tubular cells胱氨酸蛋白酶调节肾近端肾小管细胞中钠氢交换体3的运输和功能DOI: 10.1038/s44319-026-00736-1
npj digital medicine IF: 15.100Ahead of Print.No.139Evaluating eRAMP telecare for diabetes in outpatient clinics: a hybrid effectiveness-implementation study评估eRAMP远程护理在糖尿病门诊中的混合效果-实施研究DOI: 10.1038/s41746-026-02424-9
Osteoporosis international IF: 05.400Ahead of Print.No.140Clinical impact of acute symptomatic vertebral fractures in the United States: A patient survey and chart review美国急性症状性椎体骨折的临床影响：一项患者调查和病历回顾DOI: 10.1007/s00198-026-07951-5
Prostate Cancer Prostatic Dis IF: 05.800Ahead of Print.No.141Mitochondrial dysfunction in urologic disease泌尿系统疾病中的线粒体功能障碍DOI: 10.1038/s41391-026-01097-5
Scientific reports IF: 03.900Ahead of Print.No.142Reduced cortical thickness in individuals with congenital adrenal hyperplasia (CAH)先天性肾上腺增生（CAH）患者的皮质厚度降低DOI: 10.1038/s41598-026-45407-2
J Occup Environ Med IF: 01.400Ahead of Print.No.143Comprehensive Assessment of Cardiovascular Risk Factors among Long-Haul Truck Drivers in South Brazil and its Impact on 3-year follow-up of Cardiovascular Events巴西南部长途卡车司机心血管危险因素综合评估及其对3年心血管事件随访的影响DOI: 10.1097/JOM.0000000000003715
Journal of molecular histology IF: 02.200Volume 57, Issue 2No.144Ocimum tenuiflorum L. extracts attenuate polycystic ovarian syndrome in letrozole treated female Wistar rats through modulation of iNOS, COX-2, IL-1β and TNF-α罗勒（Ocimum tenuiflorum L.）提取物通过调节iNOS、COX-2、IL-1β和TNF-α缓解来曲唑处理的雌性Wistar大鼠的多囊卵巢综合征DOI: 10.1007/s10735-026-10774-7
Hypertension Research IF: 04.600Ahead of Print.No.145Sex-specific trajectories of blood pressure and pulse pressure across body mass index categories: a descriptive study based on 13-year health checkup data不同体重指数类别下血压和脉压的性别特异性轨迹：基于13年体检数据的描述性研究DOI: 10.1038/s41440-026-02607-7
Plant Physiol Biochem IF: 05.700Volume 232, Issue No.146Combined "omics" and physiological approaches highlight the roles of the GABA shunt and mitochondria-related functions in rice seed longevity综合“组学”与生理学方法凸显GABA分流途径和线粒体相关功能在水稻种子寿命中的作用DOI: 10.1016/j.plaphy.2026.111094
Medicine and Pharmacy ReportsVolume 99, Issue 1No.147Diabetes knowledge and socio-economic status among adults with type 2 diabetes2型糖尿病成人患者的糖尿病知识与社会经济地位DOI: 10.15386/mpr-2909
J Multidiscip Healthc IF: 02.400Volume 19, Issue No.148Factors Influencing Poor Drug Compliance Among Patients with Diabetes Mellitus: An Experience from Rural Indonesia印度尼西亚农村地区2型糖尿病患者药物不依从性：2023年印尼健康调查结果DOI: 10.2147/JMDH.S563957
Patient preference and adherence IF: 02.000Volume 20, Issue No.149Development and Psychometric Validation of the ASMA Medication Adherence Questionnaire for Adults with Type 2 Diabetes in Saudi Arabia: A Cross-Sectional Study沙特阿拉伯成年2型糖尿病患者ASMA药物依从性问卷的开发及心理测量学验证：一项横断面研究DOI: 10.2147/PPA.S603658
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.150Waist-to-Height Ratio and the Risk of Cardiovascular Outcomes and Mortality in Type 2 Diabetes With and Without Abdominal Obesity腰高比与有或无腹型肥胖的2型糖尿病患者心血管事件和死亡率风险DOI: 10.1111/dom.70683
Langmuir IF: 03.900Ahead of Print.No.151Generation of Membrane-Damaging hIAPP Oligomers via Direct Interaction with DOPC/DOPS NanodiscshIAPP寡聚体通过与DOPC/DOPS纳米盘的直接相互作用生成DOI: 10.1021/acs.langmuir.5c05718
JSAMS plusVolume 5, Issue No.152Outcomes of anterior cruciate ligament reconstruction surgery from private and public healthcare services in Australia澳大利亚私立与公立医疗服务中前交叉韧带重建手术的效果DOI: 10.1016/j.jsampl.2025.100088
Curēus IF: 01.300Volume 18, Issue 2No.153Prognostic Nutritional Index (PNI) in Patients With Diabetes and Sepsis: A Cross-Sectional Study糖尿病合并脓毒症患者的预后营养指数(PNI)：一项横断面研究DOI: 10.7759/cureus.104004
Frontiers in public health IF: 03.400Volume 14, Issue No.154Instant messaging-based digital health interventions for diabetes management: a domain-structured systematic review and meta-analysis of randomized controlled trials基于即时通讯的数字健康干预用于糖尿病管理：一项针对随机对照试验的领域结构化系统综述和荟萃分析DOI: 10.3389/fpubh.2026.1780625
Ann Ib Postgrad MedVolume 23, Issue 3No.155EPIDEMIOLOGY, DIAGNOSIS, MANAGEMENT AND PREVENTION OF STROKE: A NARRATIVE REVIEW卒中的流行病学、诊断、管理与预防：一篇叙述性综述https://pubmed.ncbi.nlm.nih.gov/41878074
Ann Ib Postgrad MedVolume 23, Issue 3No.156SOCIO-CLINICAL DEMOGRAPHICS AND RISK FACTORS FOR HEART FAILURE AT A TERTIARY HOSPITAL IN SOUTH-SOUTH NIGERIA: A CROSS-SECTIONAL STUDY尼日利亚南南地区三级医院心力衰竭社会临床人口统计学及危险因素：一项横断面研究https://pubmed.ncbi.nlm.nih.gov/41878068
Medicine and Pharmacy ReportsVolume 99, Issue 1No.157Post-COVID-19: effects on mental health and metabolic markers in type 2 diabetes新冠疫情后：对2型糖尿病患者心理健康和代谢指标的影响DOI: 10.15386/mpr-2911
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.158Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signalingMS-275通过Akt/ARK5-FoxO和肌抑素-Smad信号通路表观遗传抑制I类组蛋白去乙酰化酶以减轻糖尿病性骨骼肌萎缩DOI: 10.3389/fendo.2026.1788603
Continence IF: 01.200Volume 17, Issue No.159Lessons learned from conducting a multi-center lower urinary tract physiology study: the LURN experience多中心下尿路生理学研究的经验教训：LURN项目DOI: 10.1016/j.cont.2026.102320
Patient preference and adherence IF: 02.000Volume 20, Issue No.160Adherence to Self-Care and Associated Factors Among Patients with Type 2 Diabetes in Southwestern Iran伊朗西南部2型糖尿病患者的自我护理依从性及相关因素DOI: 10.2147/PPA.S569158
Clinical ophthalmology IF: 02.200Volume 20, Issue No.161Genotype Association of VEGF Polymorphism rs2010963 with Strabismus in a Pakistani Cohort: A Case-Control StudyVEGF多态性rs2010963与巴基斯坦队列中斜视的基因型关联：一项病例-对照研究DOI: 10.2147/OPTH.S558601
BMJ medicine IF: 10.000Volume 5, Issue 1No.162Accumulation and attenuation of cardiovascular benefit with glucagon-like peptide 1 receptor agonists胰高血糖素样肽1受体激动剂对心血管益处的累积与衰减DOI: 10.1136/bmjmed-2026-002704
Therapeutische Umschau IF: 00.200Volume 83, Issue 1No.163[Pharmacological post-acute treatment of alcohol use disorder: Established strategies and innovative approaches]酒精使用障碍的药理学急性后治疗：既定策略与创新方法DOI: 10.23785/TU.2026.01.006
RSC advances IF: 04.600Volume 16, Issue 18No.164Enhanced biosensing of diabetes biomarkers by using rationally engineered carbon dots碳点基生物传感在糖尿病检测中的最新进展DOI: 10.1039/d5ra08089d
Frontiers in aging IF: 04.300Volume 7, Issue No.165Neurosenescence, inflammaging and neuroinflammation in neurodegenerative disorders神经衰老、炎性衰老及神经炎症在神经退行性疾病中的研究DOI: 10.3389/fragi.2026.1756670
Medicine and Pharmacy ReportsVolume 99, Issue 1No.166Assessment of triglyceride glucose index and triglyceride to HDL cholesterol ratio as markers of insulin resistance defined by the Homeostatic Model Assessment 2 in Middle Eastern adults with excess adiposity甘油三酯-葡萄糖指数与甘油三酯/高密度脂蛋白胆固醇比值作为稳态模型评估2定义的胰岛素抵抗标志物在中东超重成人中的评估DOI: 10.15386/mpr-2950
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.167Syntaxin 4 protects islet β-cells from cytokine-induced senescenceSyntaxin 4过表达减轻1型糖尿病中的β细胞衰老DOI: 10.3389/fendo.2026.1725252
Molecular therapy IF: 12.000Ahead of Print.No.168A cartilage-targeted IGF-1-antibody fusion protein as a new therapeutic approach for IGF-1 deficiency软骨靶向IGF-1抗体融合蛋白作为IGF-1缺乏症的新治疗方法DOI: 10.1016/j.ymthe.2026.03.020
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.169Automated Insulin Delivery in Young Children with Type 1 Diabetes: A Systematic Review and Meta-Analysis1型糖尿病幼儿的自动胰岛素输送：系统综述与荟萃分析DOI: 10.1210/clinem/dgag133
Acta neuropsychiatrica IF: 02.500Ahead of Print.No.170Childhood Trauma and Physical Activity Link Immunometabolic Biomarkers and Psychiatric Symptoms in Medically Healthy Adults童年创伤与体力活动关联免疫代谢生物标志物及精神症状在医疗健康成年人中的研究DOI: 10.1017/neu.2026.10069
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.171Glycemic Control During the Menstrual Cycle in Women With Type 1 Diabetes: Performance of an Automated Insulin Delivery System1型糖尿病女性在月经周期中的血糖控制：自动化胰岛素输注系统的表现DOI: 10.1111/dom.70673
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.172Monlunabant in adults with obesity and metabolic syndrome: Open-label extension of a phase 2a trialMonlunabant用于患有肥胖和代谢综合征的成年人：2a期试验的开放标签扩展研究DOI: 10.1111/dom.70580
BMJ open IF: 02.300Volume 16, Issue 3No.173Combining structured exercise with a low-energy diet to attenuate lean mass loss in South Asian adults living with type 2 diabetes: the COMBINE randomised trial protocol将结构化运动与低能量饮食结合以减轻患有2型糖尿病的南亚成年人瘦体重流失：COMBINE随机试验方案DOI: 10.1136/bmjopen-2025-110459
Comprehensive physiology IF: 05.200Volume 16, Issue 2No.174A Single Bout of Aerobic Exercise Increases Neuronal Extracellular Vesicle-Derived Insulin Signaling Biomarkers in Adults With Cardiometabolic Risk一次有氧运动可增加具有心脏代谢风险成年人的神经元细胞外囊泡衍生胰岛素信号生物标志物DOI: 10.1002/cph4.70131
AAPS PharmSciTech IF: 04.000Volume 27, Issue 3No.175Microneedle-Assisted Delivery of Biologics: From Large Molecules to Cancer Vaccines微针辅助生物制剂递送：从大分子到癌症疫苗DOI: 10.1208/s12249-026-03387-6
EMBO molecular medicine IF: 08.300Ahead of Print.No.176IGFBP3 repression driven by inflammation links air pollution to placental and developmental defects炎症驱动的IGFBP3抑制将空气污染与胎盘及发育缺陷联系起来DOI: 10.1038/s44321-026-00403-x
Scientific reports IF: 03.900Ahead of Print.No.177Hipk transduces nutrient signals to control intestinal stem cell proliferation and fate in DrosophilaHipk转导营养信号以调控果蝇肠道干细胞的增殖和命运DOI: 10.1038/s41598-026-45137-5
Vasc Health Risk Manag IF: 02.800Volume 22, Issue No.178Gender and Age Differences in Hypertension Screening and Cardiovascular Risk Factors in Rural Kazakhstan哈萨克斯坦农村地区高血压筛查及心血管危险因素的性别和年龄差异DOI: 10.2147/VHRM.S575431
Hypertension IF: 08.200Ahead of Print.No.179Sex Differences in Cardiac Remodeling and Dysfunction in Primary Aldosteronism原发性醛固酮增多症中心脏重塑和功能障碍的性别差异DOI: 10.1161/HYPERTENSIONAHA.125.26213
Hypertension Research IF: 04.600Ahead of Print.No.180Different effect of aldosterone on corrected HCO(3)(-) across primary aldosteronism subtypes醛固酮对不同原发性醛固酮增多症亚型中校正碳酸氢根影响的差异DOI: 10.1038/s41440-026-02609-5
Paediatr Perinat Epidemiol IF: 02.500Ahead of Print.No.181Associations Between Mental Health Conditions and Adverse Pregnancy Outcomes Among Active-Duty Servicewomen现役女军人心理健康状况与不良妊娠结局的关联DOI: 10.1111/ppe.70139
Circ Genom Precis Med IF: 05.500Ahead of Print.No.182Multiomics for Risk Stratification in Atherosclerotic Cardiovascular Disease动脉粥样硬化性心血管疾病风险分层的多组学方法DOI: 10.1161/CIRCGEN.125.005451
Clinical ophthalmology IF: 02.200Volume 20, Issue No.183Retinal Assessment and the Retina-Choroid Link in Precapillary Pulmonary Hypertension: A Single-Center Cross-Sectional Study毛细血管前肺动脉高压的视网膜评估及视网膜-脉络膜关联：一项单中心横断面研究DOI: 10.2147/OPTH.S590272
Renal failure IF: 03.000Volume 48, Issue 1No.184Determinants of hypoglycemia and hospitalization among hemodialysis patients with type 2 diabetes: insights from a multicenter study in a resource-limited healthcare system资源有限医疗系统中2型糖尿病血液透析患者低血糖及住院的决定因素：多中心研究见解DOI: 10.1080/0886022X.2026.2646415
Health informatics journal IF: 02.300Volume 32, Issue 1No.185Readability and understandability of online patient education on semaglutide在线司美格鲁肽患者教育资料的可读性和可理解性DOI: 10.1177/14604582261428308
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.186Lean Mass Changes With Incretin Therapy Versus Lifestyle Intervention: A Systematic Review and Meta-Analysis of Randomised Controlled Trials肠促胰素疗法与生活方式干预的瘦体重变化：随机对照试验的系统综述与荟萃分析DOI: 10.1111/dom.70666
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.187Use of Oral Semaglutide and Associated Clinical Outcomes in Thai Patients With Type 2 Diabetes: Real-World Evidence From the REALISED Study泰国2型糖尿病患者口服司美格鲁肽的使用及相关临床结局：来自REALISED研究的真实世界证据DOI: 10.1111/dom.70701
Nature communications IF: 15.700Ahead of Print.No.188Bispecific GLP-1/GLP-2 agonism in advanced type 2 diabetes: preclinical characterization and a randomized, double-blind, placebo-controlled phase I trial双特异性GLP-1/GLP-2激动作用在晚期2型糖尿病中的临床前特征描述及一项随机、双盲、安慰剂对照I期试验DOI: 10.1038/s41467-026-71080-0
Journal of asthma and allergy IF: 03.000Volume 19, Issue No.189Characteristics of Adult Severe Uncontrolled Asthma Patients in Primary Care and Modifications in Prescribed Inhalation Treatments初级保健中重度未控制哮喘的特征：一项全国性登记研究DOI: 10.2147/JAA.S585933
BMJ Open Sport Exerc Med IF: 03.200Volume 12, Issue 1No.190Association of physical fitness and overweight with mental and behavioural diagnoses in a population-based cohort of 156 202 young men义务兵役期间心肺及肌肉力量与腰围与精神和行为诊断的关系：一项基于人群的研究DOI: 10.1136/bmjsem-2025-002921
Malawi medical journal IF: 01.200Volume 37, Issue 4No.191Circulating CD16+ CD56+ Natural Killer Cells in Colorectal Cancer and Their Correlation with Survival循环中的CD16+CD56+自然杀伤细胞在结直肠癌中的作用及其与生存的相关性DOI: 10.4314/mmj.v37i4.8
Int J Chron Obstruct Pulmon Dis IF: 03.100Volume 21, Issue No.192Characterization of Patients with COPD and GOLD E Classification in the United States美国慢性阻塞性肺疾病（COPD）GOLD E级患者特征分析DOI: 10.2147/COPD.S598962
JSAMS plusVolume 6, Issue No.193Infant weight gain and motor development in relation to childhood adiposity and physical activity婴儿体重增长和运动发育与儿童肥胖及体力活动的关系DOI: 10.1016/j.jsampl.2025.100123
Medicine and Pharmacy ReportsVolume 99, Issue 1No.194Factors influencing extracorporeal shockwave lithotripsy efficiency in the management of lower pole stones影响体外冲击波碎石术在下极结石治疗中效率的因素DOI: 10.15386/mpr-2913
Frontiers in toxicology IF: 04.600Volume 8, Issue No.195Acetamiprid exerts sex-specific effects on adipose tissue of subjects with severe obesity氯虫酰胺对严重肥胖受试者的脂肪组织产生性别特异性影响DOI: 10.3389/ftox.2026.1769863
Sexual medicine IF: 02.000Volume 14, Issue 2No.196Using artificial intelligence to predict sexual health outcomes in endometriosis: a decision tree model algorithm使用人工智能预测子宫内膜异位症性健康结局：决策树模型算法DOI: 10.1093/sexmed/qfag013
ecancermedicalscience IF: 01.300Volume 20, Issue No.197The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection全球癌症负担及预防策略：发病率、死亡率和风险因素综合分析DOI: 10.3332/ecancer.2026.2071
Pediatr Gastroenterol Hepatol Nutr IF: 01.600Volume 29, Issue 2No.198High Prevalence of Steatotic Liver in Adolescents and Young Adults in a Northern California Community加利福尼亚北部社区青少年和年轻成人中脂肪性肝病的高患病率DOI: 10.5223/pghn.2026.29.2.141
Immunopharmacol Immunotoxicol IF: 03.000Ahead of Print.No.199The therapeutic potential of jaceosidin: a comprehensive review of its effects on chronic diseases荆芥素的治疗潜力：对慢性疾病影响的综合综述DOI: 10.1080/08923973.2026.2625039
Sports health IF: 02.600Ahead of Print.No.200Relationship Between Kinesiophobia and Biomechanical, Postural, and Neuromuscular Parameters of the Lower Limbs: A Systematic Review运动恐惧症与下肢生物力学、姿势及神经肌肉参数的关系：一项系统综述DOI: 10.1177/19417381261429492
Behavioral medicine IF: 02.200Ahead of Print.No.201Game, Set, and Match: A Scoping Review of Matching Characteristics for Control and Intervention Groups in Adaptive Behavioral Interventions for Physical Activity or Healthy Eating Designs for Populations with Overweight and Obesity游戏、设定与匹配：对超重和肥胖人群中针对体力活动或健康饮食的适应性行为干预中对照组与干预组匹配特征的范围综述DOI: 10.1080/08964289.2026.2641440
Cancer investigation IF: 01.900Ahead of Print.No.202The Influence of Body Mass Index on Treatment Response and Survival in HER2-Positive Breast Cancer Patients体重指数对HER2阳性乳腺癌患者治疗反应和生存的影响DOI: 10.1080/07357907.2026.2647336
Trials IF: 02.000Ahead of Print.No.203OneSTOP (One-Stop Telehealth Obesity Program): study protocol for an open-label randomized controlled trial on the use of telecare and digital platforms for multidisciplinary management of weight management and related comorbiditiesOneSTOP（一站式远程医疗肥胖项目）：一项关于使用远程护理和数字平台对体重管理及相关合并症进行多学科管理的开放标签随机对照试验的研究方案DOI: 10.1186/s13063-026-09655-x
J Transl Med IF: 07.500Ahead of Print.No.204Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stressNfil3整合昼夜节律与微生物代谢物信号以在高脂饮食应激下维持肠-肝免疫代谢稳态DOI: 10.1186/s12967-026-08000-9
BMC medicine IF: 08.300Ahead of Print.No.205The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes评估减肥是否能改善糖尿病患者卒中后功能结局的临床研究的必要性DOI: 10.1186/s12916-026-04809-9
BMC medicine IF: 08.300Ahead of Print.No.206Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice靶向STE20型激酶MST3可改善代谢功能障碍相关脂肪性肝炎且不影响小鼠肝细胞癌发展DOI: 10.1186/s12916-026-04812-0
BMC medical imaging IF: 03.200Ahead of Print.No.207Investigation of the effect of obesity on trabecular and cortical bone structure in the peri-implant region using fractal analysis and radiomorphometric indices采用分形分析和放射形态计量指标研究肥胖对种植体周围区域松质骨和皮质骨结构的影响DOI: 10.1186/s12880-026-02296-1
Comprehensive physiology IF: 05.200Volume 16, Issue 2No.208GLP-1 at the Metabolic-Cognitive Interface: Reward, Affect, and MemoryGLP-1在代谢-认知界面：奖赏、情感与记忆DOI: 10.1002/cph4.70129
British journal of dermatology IF: 09.600Ahead of Print.No.209An adipocytokine signature improves diagnostic accuracy for people living with lipoedema脂肪细胞因子特征提高脂肪性水肿患者的诊断准确性DOI: 10.1093/bjd/ljag103
Nature metabolism IF: 20.800Ahead of Print.No.210The genetics of obesity: aetiology, prevention and therapy肥胖的遗传学：病因、预防与治疗DOI: 10.1038/s42255-026-01497-w
Evidence-based dentistry : IF: 02.300Ahead of Print.No.211Should body mass index be considered when assessing caries severity in adults?评估成人龋齿严重程度时是否应考虑体重指数DOI: 10.1038/s41432-026-01217-z
International journal of obesity IF: 03.800Ahead of Print.No.212Development and validation of the EDIT weight stigma reduction checklistEDIT体重污名化减少清单的开发与验证DOI: 10.1038/s41366-026-02045-y
Ann Ib Postgrad MedVolume 23, Issue 3No.213A PROSPECTIVE, OBSERVATIONAL STUDY ON ETIOLOGICAL SPECTRUM OF END STAGE KIDNEY DISEASE IN NORTH INDIA: DOMINANCE OF DIABETIC KIDNEY DISEASE AND EMERGING TRENDS北印度终末期肾脏病病因谱前瞻性观察研究：糖尿病肾病主导地位及新兴趋势https://pubmed.ncbi.nlm.nih.gov/41878067
Circulation: Heart Failure IF: 08.400Ahead of Print.No.214Mechanisms of GLP-1 Receptor Agonists in HFpEF: Exploring Weight-Dependent and Independent Drivers of Therapeutic BenefitGLP-1受体激动剂在射血分数保留的心力衰竭中的作用机制：探索治疗获益的体重依赖性及非依赖性驱动因素DOI: 10.1161/CIRCHEARTFAILURE.125.013279
JAHA IF: 05.300Ahead of Print.No.215Trends in Polypharmacy Among Patients With Atrial Fibrillation: A Report From the Finnish AntiCoagulation in Atrial Fibrillation Nationwide Cohort Study房颤患者多重用药趋势：芬兰房颤抗凝全国队列研究报告DOI: 10.1161/JAHA.125.046930
BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.216Cutaneous adverse drug reactions in patients with congenital heart disease: a systematic review with focus on perioperative outcomes先天性心脏病患者皮肤药物不良反应：一项重点关注围手术期结局的系统综述DOI: 10.1186/s12872-026-05774-0
Curēus IF: 01.300Volume 18, Issue 2No.217Epidemiology and Short-Term Outcomes of Acute Coronary Syndrome in a Nigerian Tertiary Hospital: A Prospective Cohort Study尼日利亚南部急性冠脉综合征的流行病学和临床特征：一项前瞻性队列研究DOI: 10.7759/cureus.104005
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 2No.218Reevaluating the Need for Routine IGF-1 Screening in Poorly Controlled Type 2 Diabetes Mellitus重新评估对血糖控制不佳的2型糖尿病患者进行常规IGF-1筛查的必要性DOI: 10.1002/edm2.70194
Child's nervous system IF: 01.200Volume 42, Issue 1No.219Endoscopic transnasal surgery for pituitary neuroendocrine tumors (Pit-NETs) in children and young adolescents (CYP) - clinical profile, outcomes and sino-nasal quality of life - an Institutional Experience儿童和青少年（CYP）垂体神经内分泌肿瘤（Pit-NETs）的内镜经鼻手术——临床特征、结局及鼻鼻窦生活质量：一项机构经验DOI: 10.1007/s00381-026-07215-x
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.220Chronic inflammatory activity in women with normogonadotropic anovulation complicated by subclinical thyroid dysfunction: a prospective cohort study促性腺激素正常性无排卵合并亚临床甲状腺功能异常女性的慢性炎症活动：一项前瞻性队列研究DOI: 10.3389/fendo.2026.1772362
Food & function IF: 05.400Ahead of Print.No.221Effects of olive leaf polyphenols on blood lipid profiles and cardiovascular risk markers in healthy and at-risk populations: a narrative review橄榄叶多酚对健康人群和高危人群血脂谱及心血管风险标志物的影响：一项叙述性综述DOI: 10.1039/d5fo04678e
Transplantation direct IF: 01.900Volume 12, Issue 4No.222Donation After Circulatory Death Islets are Comparable to Standard-of-Care Donation After Brain Death Islets: Analysis of 801 Consecutive Human Islet Isolations心脏死亡捐献胰岛与脑死亡捐献胰岛在临床胰岛移植中效果相当DOI: 10.1097/TXD.0000000000001930
Medicine and Pharmacy ReportsVolume 99, Issue 1No.223Clinical studies on the effect of type 1 diabetes on oral health in children and adolescents aged 6-17 years. A literature review儿童和青少年1型糖尿病与口腔健康DOI: 10.15386/mpr-2889
221
Diabetes Mellitus(DM)
糖尿病
78
Obesity
肥胖症
60
Insulin
胰岛素
21
Type 2 diabetes mellitus(T2DM)
2型糖尿病
17
Metabolic Syndrome
代谢综合征
17
Diabetic Foot
糖尿病足
10
Hypoglycemic Agents
降糖药
9
Metformin
二甲双胍
9
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
8
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
6
Semaglutide
司美格鲁肽
6
Tirzepatide
替尔泊肽
5
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
5
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
4
Diabetes Complications
糖尿病并发症
4
Type 1 diabetes mellitus(T1DM)
1型糖尿病
3
Diabetic Retinopathy
糖尿病视网膜病
2
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
2
Diabetic acidosis
糖尿病性酸中毒
2
Dapagliflozin
达格列净
1
Dulaglutide
度拉糖肽
1
Liraglutide
利拉鲁肽
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Gabapentin
加巴喷丁
1
Pregabalin
普瑞巴林
编辑：韩玉莲
审校：韩玉莲
临床研究
100 项与 屈昔多巴 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 糖尿病性神经病变 | 美国 | 2014-02-18 | |
| 头晕 | 美国 | 2014-02-18 | |
| 多巴胺β-羟化酶缺乏症 | 美国 | 2014-02-18 | |
| 直立性低血压 | 日本 | 2000-07-03 | |
| 家族性淀粉样神经病 | 日本 | 1989-01-17 | |
| 帕金森病 | 日本 | 1989-01-17 | |
| Shy-Drager综合征 | 日本 | 1989-01-17 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 体位性高血压 | 临床3期 | 美国 | 2013-11-01 | |
| 直立性低血压症状 | 临床3期 | 美国 | 2008-01-01 | |
| 直立性低血压症状 | 临床3期 | 澳大利亚 | 2008-01-01 | |
| 直立性低血压症状 | 临床3期 | 加拿大 | 2008-01-01 | |
| 直立性低血压症状 | 临床3期 | 新西兰 | 2008-01-01 | |
| 多系统萎缩 | 临床3期 | 美国 | 2008-01-01 | |
| 多系统萎缩 | 临床3期 | 澳大利亚 | 2008-01-01 | |
| 多系统萎缩 | 临床3期 | 加拿大 | 2008-01-01 | |
| 多系统萎缩 | 临床3期 | 新西兰 | 2008-01-01 | |
| 神经源性直立性低血压 | 临床3期 | 美国 | 2008-01-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床4期 | 22 | 壓窪淵獵夢餘夢蓋築蓋 = 築壓觸壓築網鬱膚壓製 積構選築艱鬱衊鹹夢鏇 (餘願夢積構壓鏇觸廠襯, 廠鑰蓋範衊壓艱製觸構 ~ 壓夢憲壓選醖簾壓鹽積) 更多 | - | 2025-03-07 | |||
临床2期 | 20 | 製鏇襯鹽襯窪窪艱蓋構(鹹齋糧鑰蓋壓構願鹹膚) = 遞繭鏇襯願壓製壓衊衊 蓋膚憲觸壓築鹽壓鹽淵 (選選鬱願積鹽範繭淵遞, 10.4) 更多 | - | 2024-04-18 | |||
製鏇襯鹽襯窪窪艱蓋構(鹹齋糧鑰蓋壓構願鹹膚) = 範窪壓艱製獵糧觸製獵 蓋膚憲觸壓築鹽壓鹽淵 (選選鬱願積鹽範繭淵遞, 4.1) 更多 | |||||||
临床4期 | 453 | (Double-Blind Droxidopa) | 鏇繭醖淵願窪蓋選願鹹 = 選衊選襯築膚鏇繭壓艱 範廠簾醖窪廠鬱衊廠構 (壓築願鬱顧製衊鹽觸醖, 醖積範餘鹽繭艱製壓鏇 ~ 齋範鹽網觸築鑰鏇獵繭) 更多 | - | 2023-08-23 | ||
placebo+droxidopa (Double-Blind Placebo) | 鏇繭醖淵願窪蓋選願鹹 = 構窪夢鏇艱壓壓觸範獵 範廠簾醖窪廠鬱衊廠構 (壓築願鬱顧製衊鹽觸醖, 齋築廠範衊蓋觸廠願鑰 ~ 獵餘鑰蓋顧壓糧鏇夢製) 更多 | ||||||
临床4期 | 9 | 餘壓醖築憲鬱鏇簾積醖(顧齋窪艱鑰鹽鑰製願顧) = 築遞壓淵壓膚鹹簾夢壓 鏇遞糧鏇簾範壓餘製壓 (蓋夢顧窪糧鹹積蓋繭餘, 1.9) 更多 | - | 2022-09-26 | |||
临床2/3期 | 8 | (Droxidopa 25 mg) | 憲蓋齋選壓鬱壓醖鬱窪(廠艱壓鑰網簾製壓夢膚) = 鹽廠構觸築窪獵夢鏇鏇 齋艱顧餘蓋顧齋觸簾觸 (襯選夢遞鑰糧獵襯願膚, 選網憲夢蓋鬱網築糧蓋 ~ 繭鏇獵網醖觸鹽選製簾) 更多 | - | 2022-03-02 | ||
(Droxidopa 50 mg) | 憲蓋齋選壓鬱壓醖鬱窪(廠艱壓鑰網簾製壓夢膚) = 鹽餘淵醖鬱積觸鏇鹹膚 齋艱顧餘蓋顧齋觸簾觸 (襯選夢遞鑰糧獵襯願膚, 膚選襯鏇鏇鹽衊襯簾繭 ~ 築淵遞範糧積繭膚艱鏇) 更多 | ||||||
临床4期 | 114 | 觸鏇製鹽鹹願鬱衊網夢(糧鹹積鑰壓壓蓋網構齋) = 9% 範壓醖膚齋願艱顧遞窪 (壓憲壓膚鹹繭鏇蓋憲糧 ) 更多 | 积极 | 2022-02-02 | |||
临床4期 | 15 | 衊淵淵鑰艱網簾願廠餘 = 蓋膚製製繭繭艱齋淵鹽 鏇淵選獵糧範構積鏇齋 (簾築製餘壓積膚醖夢蓋, 鬱艱襯範構網獵醖積遞 ~ 衊獵構鏇觸憲餘製築網) 更多 | - | 2020-01-27 | |||
临床1期 | - | 24 | Droxidopa in the fed state | 遞網鏇糧遞醖網膚糧餘(顧醖膚鑰醖觸構壓範獵) = 淵蓋選選鏇膚願積顧繭 廠鬱廠襯願鹹獵膚窪繭 (憲蓋繭繭憲糧夢鬱憲製 ) 更多 | - | 2018-03-01 | |
Droxidopa in the fasted state | 遞網鏇糧遞醖網膚糧餘(顧醖膚鑰醖觸構壓範獵) = 顧憲繭製積夢餘窪鏇選 廠鬱廠襯願鹹獵膚窪繭 (憲蓋繭繭憲糧夢鬱憲製 ) 更多 | ||||||
临床3期 | 222 | 鏇獵範製顧膚範鬱簾艱(願構網鬱遞艱憲網遞艱) = 觸構鹽願壓壓艱觸觸膚 鏇醖獵壓鏇襯蓋餘齋齋 (製窪夢選簾夢顧範鑰窪 ) | - | 2017-06-04 | |||
Placebo | 鏇獵範製顧膚範鬱簾艱(願構網鬱遞艱憲網遞艱) = 範齋醖醖齋衊選鹽選鏇 鏇醖獵壓鏇襯蓋餘齋齋 (製窪夢選簾夢顧範鑰窪 ) | ||||||
临床1/2期 | 体位性心动过速综合征 | 疲劳 | 8 | 夢選顧鏇膚餘艱築糧願(夢積窪糧餘窪範憲鏇構) = 鏇築製廠齋構網鏇蓋鬱 選齋廠膚膚網衊醖膚壓 (繭鹹簾鏇顧壓製選積廠, 顧積鹽夢鏇繭醖襯壓餘 ~ 積齋齋衊淵齋獵襯鬱觸) 更多 | - | 2017-05-18 | ||
Placebos (Placebos) | 夢選顧鏇膚餘艱築糧願(夢積窪糧餘窪範憲鏇構) = 鏇鑰鹹觸顧製積餘構鏇 選齋廠膚膚網衊醖膚壓 (繭鹹簾鏇顧壓製選積廠, 製鹹願壓繭選網艱蓋餘 ~ 窪齋網夢鏇製衊網願蓋) 更多 |
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