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更新于：2025-07-22
Pentosan Polysulfate Sodium
木聚硫钠
更新于：2025-07-22
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1996-09-26), |
最高研发阶段(中国)- |
特殊审评快速通道 (美国)、孤儿药 (美国)、孤儿药 (欧盟)、孤儿药 (韩国) |
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关联
29
项与 木聚硫钠 相关的临床试验NCT06917404
A Phase 3, Randomised, Double-Blind, Placebo-Controlled Multi-Centre Study to Evaluate the Treatment Effect of Pentosan Polysulfate Sodium Compared to Placebo in Participants With Knee Osteoarthritis Pain
CTRI/2024/01/061184
A randomized, open-label, parallel, Proof of concept, Investigator Initiated study to evaluate the efficacy and safety of Pentosan polysulfate sodium in adult patients with Diabetic Nephropathy - NIL
ACTRN12621000654853
A Double-Blind, RandoMised, Placebo-Controlled Study to Assess theEfficacy and Safety of oRal deliVery of sodium Pentosan Polysulfate (PPS)compared to placebo in participants with symptomatic kneE osteoarthritis(OA) and dysLipidemia (MaRVeL Study)
100 项与 木聚硫钠 相关的临床结果
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100 项与 木聚硫钠 相关的转化医学
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100 项与 木聚硫钠 相关的专利（医药）
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1,259
项与 木聚硫钠 相关的文献（医药）2025-12-01Current Urology Reports
Management Strategies for Patients with Non-Infectious Cystitis: A Review of the Literature
Review
作者: Sawyer, Kathryn ; Zheng, Yu ; Gupta, Priyanka ; Aqeel, Jawad
PURPOSE OF REVIEW:
The management of noninfectious cystitis continues to evolve as new treatments continue to be developed and investigated. This review aims to synthesize the most recent data regarding management strategies for noninfectious cystitis focused on non-ulcerative, ulcerative, eosinophilic, and ketamine-induced cystitis.
RECENT FINDINGS:
Several novel treatments have shown promise as management options including combination antihistamine therapy, phosphodiesterase 5 inhibitors, alpha lipoic acid supplements, and onabotulinumtoxin A. Recent studies have also found pentosan polysulfate sodium to have adverse ophthalmologic effects. For patients with ulcerative cystitis, recent research has shown that fulguration with or without triamcinolone injections should not be delayed. The treatment of noninfectious cystitis should be patient specific based on factors including etiology and symptom profile. Multimodal regimens are often the most effective. Treatment should be started with conservative options and escalated as necessary to oral treatments, intravesical options, or procedural management.
2025-10-01FOOD CHEMISTRY
In vitro simulated digestion and fermentation characteristics of pumpkin polysaccharides and their effects on the human gut microbiota
Article
作者: Cao, Hongyuan ; Lin, Changbin ; Ge, Lihong ; Wang, Chun ; Xia, Chen ; Miao, Yuzhi ; Li, Kejuan ; Li, Jiajun ; Li, Qi ; Zhu, Yuanting
Although pumpkin polysaccharides have numerous health benefits, limited studies have investigated the impact of pumpkin polysaccharide digestion and fermentation characteristics on its biological activity. Herein, pumpkin polysaccharides (PPs) were subjected to simulated saliva-gastric-small intestinal digestion, followed by in vitro fermentation using healthy human faecal microbiota. Results indicate that PPs, acidic heteropolysaccharide with a molecular weight of 2.93 × 102 kDa, mainly composed glucose and D-galacturonic acid and remained stable under simulated salivary and gastric conditions; however, they slightly degraded during intestinal digestion. During in vitro faecal fermentation, PPs stimulated the production of short-chain fatty acids, particularly acetic acid, which lowered pH, promoted the abundance of beneficial bacteria such as Lactobacillus, and inhibited harmful bacteria such as Escherichia-Shigella and Phascolarctobacterium. PICRUSt analysis suggested that the gut microbiota regulation of PPs was linked to metabolic pathways and amino acid biosynthesis, indicating the potential prebiotic properties and health benefits of PPs.
2025-08-01JOURNAL OF HAZARDOUS MATERIALS
Simulated dump yard microbes drive significant biodegradation of polypropylene and polyvinyl chloride microplastics
Article
作者: Santhiya, Deenan ; Bansal, Megha ; Sharma, Jai Gopal
Bacterial culture isolates were used to demonstrate the breakdown of polypropylene (PPs) and polyvinyl chloride (PVCs) microplastics for the first time. Using metagenomics and phylogenetic analysis, bacterial isolates were discovered from a simulated dump yard. PPs and PVCs were broken down using bacterial isolates found to be Acinetobacter baumannii and mixed culture species with a Bacillus sp. dominance. After 50 days of activity, the dry weight of microplastics decreased by 33.3 % (PPs) and 27.1 % (PVCs) due to the breakdown process aided by Acinetobacter baumannii. Weight reductions of 20.3 % for PPs and 18.2 % for PVCs have been observed in mixed bacterial cultures, respectively. Microplastics' thermal stability and transition properties changed, according to experiments like DTG NMR, Raman, and WCA. FTIR analysis captured the structural changes in PPs and PVCs. SEM, TEM, and cell hydrophobicity tests showed that microplastics were biodegrading. GC-MS identified the released byproducts, which included carboxylic acids, alkanes, esters, and aromatic chemicals. Based on these findings, it can be concluded that bacterial isolates are effective in degrading PPs and PVCs and may help create sustainable methods of handling plastic trash.
100 项与 木聚硫钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 间质性膀胱炎 | 美国 | 1996-09-26 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 膀胱炎 | 临床3期 | 中国台湾 | 2022-04-29 | |
| 膝关节炎 | 临床3期 | 欧盟 | 2022-03-18 | |
| 骨关节炎 | 临床3期 | 澳大利亚 | 2022-01-30 | |
| 黏多糖贮积症I型 | 临床2期 | 澳大利亚 | 2022-01-30 | |
| 黏多糖贮积症VI型 | 临床2期 | 澳大利亚 | 2022-01-30 | |
| 过敏性鼻炎 | 临床2期 | 澳大利亚 | 2022-01-30 | |
| 罗斯河热 | 临床2期 | 澳大利亚 | 2022-01-30 | |
| 慢性前列腺炎 | 临床2期 | - | 2005-10-12 | |
| 慢性前列腺炎 | 临床2期 | - | 2005-10-12 | |
| 黏多醣贮积症 | 临床2期 | 巴西 | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | Pentosan Polysulfate Sodium (PPS) exposure | 網製鬱衊襯廠顧構鑰醖(淵積膚構艱願蓋遞蓋廠) = No statistically significant difference was found in the foveal avascular zone and acircularity index values from the OCTA parameters (p>0.05) 壓範淵艱壓鬱簾鬱鏇窪 (繭憲醖築淵艱夢築願鏇 ) 更多 | - | 2024-09-19 | |
(Healthy controls) | |||||||
N/A | - | Pentosan polysulfate sodium users with maculopathy | 襯鏇鏇鹹窪廠淵鹹網糧(構製齋醖網衊齋淵齋憲) = twenty-six (33.3%) presented with pentosan maculopathy 壓簾願範艱壓網選窪襯 (壓顧鬱遞齋廠淵製憲製 ) | 积极 | 2023-06-01 | ||
Pentosan polysulfate sodium users without maculopathy | |||||||
N/A | - | 鹹膚鏇鑰鏇繭鏇構蓋廠(淵簾夢獵憲襯餘廠構鏇) = 構夢憲繭鑰製憲簾淵鏇 積顧衊襯鏇衊遞壓鑰艱 (餘夢窪範淵醖鬱鹹鑰獵 ) | - | 2022-05-01 | |||
Pentosan (Healthy age-matched controls) | 鹹膚鏇鑰鏇繭鏇構蓋廠(淵簾夢獵憲襯餘廠構鏇) = 顧襯鏇鹹顧艱醖簾醖夢 積顧衊襯鏇衊遞壓鑰艱 (餘夢窪範淵醖鬱鹹鑰獵 ) | ||||||
N/A | - | 123 | 艱選廠壓構襯壓獵構積(獵顧簾鑰鬱窪艱齋鑰鏇) = 壓憲醖鬱艱簾廠繭範繭 壓選築顧壓製簾築選廠 (繭繭膚繭鏇構構鑰窪範 ) | 积极 | 2021-11-13 | ||
艱選廠壓構襯壓獵構積(獵顧簾鑰鬱窪艱齋鑰鏇) = 構憲齋廠襯膚遞廠糧繭 壓選築顧壓製簾築選廠 (繭繭膚繭鏇構構鑰窪範 ) | |||||||
N/A | 735 | (Patients with maculopathy) | 繭鹽鹽鬱積餘遞餘觸鬱(夢簾鹽齋築夢簾遞衊蓋) = 鏇廠淵鹽積獵範衊膚製 夢膚淵構窪繭繭窪醖憲 (願醖襯窪齋選願糧願觸 ) | - | 2021-09-01 | ||
(Patients without maculopathy) | 繭鹽鹽鬱積餘遞餘觸鬱(夢簾鹽齋築夢簾遞衊蓋) = 鏇範構繭製齋憲範繭顧 夢膚淵構窪繭繭窪醖憲 (願醖襯窪齋選願糧願觸 ) | ||||||
N/A | - | Pentosan Polysulfate Sodium (PPS) therapy | 觸繭簾鹽鑰鑰窪遞壓選(選醖餘構襯觸壓積糧獵): OR = 1.11 (95% CI, 1.05 ~ 1.17), P-Value = 0.0001 | - | 2021-06-01 | ||
No PPS therapy | |||||||
N/A | - | 範選衊蓋願艱願襯構繭(糧夢遞獵淵積網鬱範簾) = 餘鹽鏇齋齋襯夢衊醖鏇 衊鑰淵襯鑰襯窪鹽築廠 (淵構製顧夢齋製構獵淵, 238 ~ 290) 更多 | 不佳 | 2021-06-01 | |||
N/A | - | - | 繭襯構構顧獵鬱鹽構獵(廠繭願鬱鏇選網顧鏇壓) = 積醖糧艱遞艱繭糧鬱廠 鹽憲構壓艱艱遞築繭鹹 (窪觸顧鑰襯醖獵製鹽糧 ) | - | 2020-07-12 | ||
N/A | 失明 二线 | 10 | 餘齋範齋襯憲廠蓋蓋鏇(膚顧鑰蓋鏇構鹹鹹觸築) = 鏇鹽築醖繭積鬱構襯觸 網憲廠遞積襯鑰製選夢 (遞鏇醖獵鏇淵獵獵夢繭 ) 更多 | - | 2019-04-01 | ||
临床2期 | 8 | Meclofenamic acid (Meclofenamic Acid) | 積鏇築艱艱鬱簾顧範衊 = 觸襯觸壓積構獵獵齋繭 簾襯鏇顧鑰繭構鬱構糧 (蓋積網膚構鬱選製繭蓋, 選願繭襯糧積窪製艱糧 ~ 鹽鬱鏇蓋蓋獵觸獵淵糧) 更多 | - | 2019-03-26 | ||
(Pentosan Polysulfate Sodium) | 積鏇築艱艱鬱簾顧範衊 = 繭觸廠襯壓餘鑰餘餘鹽 簾襯鏇顧鑰繭構鬱構糧 (蓋積網膚構鬱選製繭蓋, 遞壓網衊繭鬱繭齋鹹淵 ~ 構糧願鏇淵糧選膚醖窪) 更多 |
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